Adaptil Travel Calming Spray for Dogs #1 brand used and recommended by veterinarians. Clinically proven to help reduce signs of stress such as crying, shaking and pacing during car travel in as little as 5 minutes. Drug-free solution that helps make travel and visits to the vet less stressful. During car trips, spray directly in your car where your dog sits or sleeps. Can also be sprayed on collars, bandanas, blankets or beds.