ZYMOX Otic Plus Ear Solution | The Only No Pre-Clean Once -a-Day Dog and Cat Ear Solution | Natural Enzyme Formula | Veterinarian Recommended | Patented Enzyme Formula | Contains Hydrocortisone for Comfort #1 Best-Selling and Effective Solution: Formulated for cats and dogs to manage problematic ears. ZYMOX's patented formula is safe and gentle and is a natural alternative to traditional therapy. Instantly starts working to clean pet's ears and rid of build up and debris to help reduce the possibility of irritation. Otic Plus adds an additional enzyme system that goes deeper to penetrate the bacteria's biofilm. Easy, Daily, One-Step Process to clean problematic ears: No more digging in those painful ears. The natural enzymes found in ZYMOX maximize the cleaning power of this product, without traumatic pre-cleaning and application. Easy to Use and Effective: Apply generously to uncleaned ear, filling the ear canal. Gently massage underneath ear canal so that solution can work its way down and instantly begin cleaning build up that has settled in your pet's ear canal. Apply just once a day for 7 days or continue use as needed. Made in the USA: Proudly American made in a facility that practices "GMP- Good Manufacturing Practices. Our products are Animal Cruelty-Free and are never tested on animals.