Frontline Plus for Large Dogs 45-88 lbs (20-40 kg), New & Fresh, 1 Month Supply, 1 Applicator (Large, Purple) Kills all existing fleas on your pet within 12 hours Each application provides a full month of protection Kills ticks and chewing lice. Also aids in the control of sarcoptic mange infections Waterproof. EPA approved product. EPA Reg. No. 65331-5. EPA Est. 65331-FR-2