| 1 | A | B | C | D | E | F | G | H | I | J | K |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 2 | clinical pharmacology |  |  |  |  |  |  |  |  |  |  |
| 3 | compound | substituents |  |  |  |  | form | cysteine binding | pka |  | first approval |
| 4 |  | x | r1 | r2 | r3 | r4 |  |  | pkaa1 | pkaa1 | year |
| 5 | omeprazole | ch | och3 | ch3 | ch3 | ch3 | racemic mixture | 813 and 892 | 4.06 | 0.79 | 1989 in usa |
| 6 | esomeprazole | ch | och3 | ch3 | ch3 | ch3 | (s)-(-)-enantiomer of omeprazole | 813 and 892 | 4.06 | 0.79 | 2001 in usa |
| 7 | lansoprazole | ch | h | ch3 | ch2cf3 | h | racemic mixture | 813 and 321 | 3.83 | 0.62 | 1991 in europe |
| 8 | dexlansoprazole | ch | h | ch3 | ch2cf3 | h | (r)-(+)-enantiomer of lansoprazole | 813 and 321 | 3.83 | 0.62 | 2009 in usa |
| 9 | pantoprazole | ch | ochf2 | och3 | ch3 | h | racemic mixture | 813 and 822 | 3.83 | 0.11 | 1994 in germany |
| 10 | rabeprazole | ch | h | ch3 | (ch2)3och3 | h | racemic mixture | 813, 892 and 321 | 4.53 | 0.62 | 1999 in usa |
| 11 | tenatoprazole | n | och3 | ch3 | ch3 | ch3 | racemic mixture | 813 and 822 | 4.04 | -0.12 | - |

Question: what is the number of rabeprazole bind to cysteine?
Answer: 813, 892 and 321