| 1 | A | B | C | D | E |
| --- | --- | --- | --- | --- | --- |
| 2 | Estradiol acetate - Available forms |  |  |  |  |
| 3 | Route | Ingredient | Form | Dose | Major brand names |
| 4 | Oral | Estradiol | Tablets | 0.1, 0.2, 0.5, 1, 2, or 4 mg per tablet | Estrace, Ovocyclin |
| 5 | Oral | Estradiol acetateb | Tablets | 0.45, 0.9, or 1.8 mg per tablet | Femtrace |
| 6 | Oral | Estradiol valerate | Tablets | 0.5, 1, 2, or 4 mg per tablet | Progynova |
| 7 | Intranasal | Estradiolb | Nasal sprays | 150 µg per spray (60 sprays per bottle) | Aerodiol |
| 8 | Transdermal | Estradiol | Patches | 14, 25, 37.5, 50, 60, 75, or 100 µg E2 per 24 hours for 3–4 or 7 days | Climara, Estraderm, Vivelle |
| 9 | Transdermal | Estradiol | Gel dispensers | 0.06% (0.87 or 1.25 g gel or 0.52 or 0.75 mg E2 per activation) | Elestrin, EstroGel |
| 10 | Transdermal | Estradiol | Gel packets | 0.1% (0.25, 0.5, or 1.0 g gel or 2.5, 5, or 10 mg E2 per packet) | DiviGel, Sandrena |
| 11 | Transdermal | Estradiol | Emulsions | 0.14% (1.74 g emulsion or 4.35 mg E2 per pouch; delivers 50 µg E2 per day) | Estrasorb |
| 12 | Transdermal | Estradiol | Sprays | 1.53 mg per spray | Evamist |
| 13 | Vaginal | Estradiol | Tablets | 10 or 25 µg per tablet | Vagifem |
| 14 | Vaginal | Estradiol | Creams | 0.01% (0.1 mg E2 per 1.0 g cream) | Estrace |
| 15 | Vaginal | Estradiol | Suppositoriesb | 4 or 40 μg per suppository | Ovocyclin |
| 16 | Vaginal | Estradiol | Inserts | 4 or 10 µg per insert (replaced daily for 2 weeks and then twice weekly) | Imvexxy |
| 17 | Vaginal | Estradiol | Rings | 2 mg per ring (provides 7.5 µg E2 per 24 hours for 3 months) | Estring |
| 18 | Vaginal | Estradiol acetate | Rings | 12.4 or 24.8 mg per ring (provide 50 or 100 µg E2 per 24 hours for 3 months) | Femring |
| 19 | Intramuscular injection | Estradiola | Ampoules | 1.0 mg/mL | Juvenum E |
| 20 | Intramuscular injection | Estradiol benzoate | Vials/ampoules | 0.167, 0.2, 0.333, 1, 1.67, 2, 5, 10, 20, or 25 mg/mL | Progynon-B |
| 21 | Intramuscular injection | Estradiol cypionate | Vials/ampoules | 1, 3, or 5 mg/mL | Depo-Estradiol |
| 22 | Intramuscular injection | Estradiol dipropionateb | Vials/ampoules | 0.1, 0.2, 0.5, 1, 2.5, or 5 mg/mL | Di-Ovocylin, Progynon-DP |
| 23 | Intramuscular injection | Estradiol enantate | Vials/ampoules | 5 or 10 mg/mL (available only in combination with a progestin) | Perlutal, Topasel |
| 24 | Intramuscular injection | Estradiol undecylateb | Vials/ampoules | 100 mg/mL | Delestrec, Progynon Depot 100 |
| 25 | Intramuscular injection | Estradiol valerate | Vials/ampoules | 5, 10, 20, or 40 mg/mL | Delestrogen, Progynon Depot |
| 26 | Intramuscular injection | Polyestradiol phosphate | Vials/ampoules | 40 or 80 mg per vial/ampoule | Estradurin |
| 27 | Subcutaneous | Estradiolc | Implants | 20, 25, 50, or 100 mg per implant (usually replaced every 6 months) | Estradiol Implants, Meno-Implant |
| 28 | Abbreviations: E2 = Estradiol. Footnotes: a = Encapsulated in microspheres. | Abbreviations: E2 = Estradiol. Footnotes: a = Encapsulated in microspheres. | Abbreviations: E2 = Estradiol. Footnotes: a = Encapsulated in microspheres. | Abbreviations: E2 = Estradiol. Footnotes: a = Encapsulated in microspheres. | Abbreviations: E2 = Estradiol. Footnotes: a = Encapsulated in microspheres. |

Question: What are the possible doses of estradiol acetate for vaginal rings, and what are the sizes of the rings?
Answer: Estradiol acetate comes in the form of 12.4 or 24.8 mg vaginal rings that release 50 or 100 μg/day estradiol for 3 months (Femring).