| 1 | A | B | C | D | E |
| --- | --- | --- | --- | --- | --- |
| 2 | Conjugated estrogens - Medical uses |  |  |  |  |
| 3 | Route/form | Estrogen | Low | Standard | High |
| 4 | Oral | Estradiol | 0.5–1 mg/day | 1–2 mg/day | 2–4 mg/day |
| 5 | Oral | Estradiol valerate | 0.5–1 mg/day | 1–2 mg/day | 2–4 mg/day |
| 6 | Oral | Estradiol acetate | 0.45–0.9 mg/day | 0.9–1.8 mg/day | 1.8–3.6 mg/day |
| 7 | Oral | Conjugated estrogens | 0.3–0.45 mg/day | 0.625 mg/day | 0.9–1.25 mg/day |
| 8 | Oral | Esterified estrogens | 0.3–0.45 mg/day | 0.625 mg/day | 0.9–1.25 mg/day |
| 9 | Oral | Estropipate | 0.75 mg/day | 1.5 mg/day | 3 mg/day |
| 10 | Oral | Estriol | 1–2 mg/day | 2–4 mg/day | 4–8 mg/day |
| 11 | Oral | Ethinylestradiola | – | 5–10 μg/day | – |
| 12 | Nasal spray | Estradiol | 150 μg/day | 300 μg/day | – |
| 13 | Transdermal patch | Estradiol | 25 μg/dayb | 50 μg/dayb | 100 μg/dayb |
| 14 | Transdermal gel | Estradiol | 0.5 mg/day | 1–1.5 mg/day | 2–3 mg/day |
| 15 | Vaginal | Estradiol | 25 μg/day | – | – |
| 16 | Vaginal | Estriol | 30 μg/day | 0.5 mg 2x/week | 0.5 mg/day |
| 17 | IM or SC injection | Estradiol valerate | – | – | 4 mg 1x/4 weeks |
| 18 | IM or SC injection | Estradiol cypionate | 1 mg 1x/3–4 weeks | 3 mg 1x/3–4 weeks | 5 mg 1x/3–4 weeks |
| 19 | IM or SC injection | Estradiol benzoate | 0.5 mg 1x/week | 1 mg 1x/week | 1.5 mg 1x/week |
| 20 | SC implant | Estradiol | 25 mg 1x/6 months | 50 mg 1x/6 months | 100 mg 1x/6 months |
| 21 | Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. | Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. | Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. | Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. | Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. |

Question: What are the recommended standard and high dosage for oral CEE?
Answer: Oral CEEs has a daily dosage of 0.625 mg and a daily dosage of 1.25 mg.