guarantees of free provision of medical care to citizens for 2017 and for the planning period 2018 and 2019."

- The average cost of drug provision at the outpatient stage, in rubles, calculated on the basis of the data of the analytical review of the Russian pharmacological market for 2017, prepared by DSM Group, for diseases of the circulatory system, respiratory system and malignant neoplasms. For diseases of diabetes mellitus, the average cost of drug provision is determined according to scientific research. For diseases of tuberculosis in an outpatient setting, drug therapy is included in the standard of financial costs.

In accordance with the Methodology, the size of the base rate for DRGs in the 24-hour and day hospitals was determined on the basis of the average standard of cost of hospitalization according to the Program of the state guarantees of free medical care to citizens for 2017 and for the planning period 2018 and 2019 (Rub 28,767.4), except for expenses on high-tech medical care, hemodialysis services (calculations were made according to the Federal compulsory health insurance Fund data received for performance of research work). Thus, the size of the base rate for the 24-hour hospital was 22,000 rubles and for the day hospitals, 10,000 rubles.

As a tariff for the cost of outpatient treatment, the average standard for the cost of outpatient visits in accordance with the Program of state guarantees for the provision of free medical care to citizens for 2017 and for the planning period of 2018 and 2019, equal to Rub 376.2 rubles, is taken.

Based on the results of the Global Adult Tobacco Survey (GATS),<sup>15</sup> the prevalence of smoking in Russia in 2016 was 30.5%.

To calculate the number of diseases associated with tobacco smoking, the generally accepted indicator in available literature, indicator of population attributable risk (PAR), was used. PAR is calculated based on the data on smoking prevalence and on the indicator of the relative risk of disease in smokers vs. nonsmokers (RR).

Calculation of the indicator of the relative risk of disease in smokers vs. non-smokers was not done, and values of the RR were taken from the open sources:

- Diabetes: during long-term follow-up: the Malmö Preventive Project. J Intern Med. 2006 Aug;260(2):134-41; http://ex-diabetic.com/vashe-zdorove/caharnyj-diabet-i-kurenie.html

- Cardio-vascular diseases:  How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General. https://www.ncbi.nlm.nih.gov/books/NBK53012/

- Respiratory diseases:  Краснова Ю.Н. Влияние табачного дыма на органы дыхания//Сибирский медицинский журнал, Том 137, No6, стр.11-16.2015 г.

- Cancer:  Ying-Ying Wang, Wei Zhang, et.al. Population attributable risks of cigarette smoking for deaths of all causes, all cancers and other chronic diseases among adults aged 40-74 years in urban Shanghai, China. Chin J Cancer Res. 2015 Feb; 27(1): 59–65.; Белялова Н.С., Белялов Ф.И. Факторы риска и профилактика рака. Часть 1. Клиническая медицина 2005;11:17-21.

- TB:  http://www.who.int/tobacco/resources/publications/ru_tfi_tb_tobacco_factsheet.pdf

Population risk of smoking (RAR) was calculated by the formula:

# RAR = ((p0+p1*RR)-1)/(p0+p1*RR)

> 15 Global Adult Tobacco Survey: Overview, 2016. https://static1.rosminzdrav.ru/system/attachments/attaches/000/036/485/original/GATS-%D0%BA%D1%80%D0%B0%D1%

82%D0% BA%D0% B8%D0% BE7af5a0856d91% 82%D1% 87%D0% B5%D1% 82-%D1% 80%D1% 83%D1% 81.pdf? 1511269867 21