|**_P.falciparum_ pr**|**evalence**<sup>f g</sup>(k=1.03)||-|<br>-||311 (12.9)|
|---|---|---|---|---|---|---|
|**CLASS 1**<sup>f h</sup><br>|||**1222**|**childr**|**en**|**1317 children**|
|Score: 0-20|(ICC=0.07)|Sustained attention<sup>h</sup>|11.9|(6.7)|[0, 20]|12.1 (6.6)[0, 20]|
|Score: 0-20|(ICC=0.29)|Spelling|8.6|(4.5)|[0, 19]|7.7 (4.4)[0, 20]|
|Score: 0-30|(ICC=0.11)|Arithmetic|2.6|(2.4)|[0, 17]|2.6 (2.5)[0, 15]|
|**CLASS 5**<sup>f h</sup>|||**1301**|**childr**|**en**|**1393 children**|
|Score: 0-20|(ICC=0.23)|Sustained attention<sup>i</sup>|9.9|(6.0)|[0, 20]|10.4 (5.7)[0, 20]|
|Score: 0-78|(ICC=0.09)|Spelling|27.9|(11.8|)[0, 63]|25.8 (11.2)[1, 59]|
|Score: 0-38|(ICC=0.22)|Arithmetic|29.4|(5.6)|[0, 38]|28.5 (5.8)[0, 38]|

> ~~a~~ % of non-missing children in each study group presented for categorized data. For continuous data mean(sd) [min,max] is presented; ~~b~~ All characteristics have less than 2% missing data with the exception of following indicators (reported as control/intervention): stunted and thin both (138/248 [5.5/9.2%] missing), underweight (1538/1744 [61.0/64.4%] missing), net use last night (661/840 [26.2/31.0%] missing).<sup>c</sup> In Class 1, mean (SD) for age is: 7.8 (1.7) and in Class 5, mean (SD) for age is:12.5 (1.6)<sup>d</sup> Percentages of treated nets and children sleeping under a net last night are presented only for those children who were reported as usually sleeping under a net<sup>e</sup> Study endpoints have less than 5% missing data at baseline with the exception of the following (reported as control/intervention): Hb (147/255 [5.8/9.4%] missing), _P.falciparum_ infection (274 [10.1%] missing in intervention group), class 5 attention (79/72 [6.1/5.2%] missing).<sup>f</sup> Coefficient of variation (k) estimated for binary outcomes using available baseline (i.e. only using data from IST schools for _P.falciparum_ ) and Intraclass correlation coefficient (ICC) estimated for continuous outcomes using baseline measures.<sup>g</sup> Not measured at baseline in the control group;<sup>h</sup> Presented as mean(sd) [min,max]<sup>i</sup> In class 1 sustained attention was measured by the “pencil tap test” and in class 5 sustained attention was measured by the “two digit code transmission test”.

|**Table 2:**Sum<br>|maryinform<br>|ation for 2710<br>|study children<br>|intheIST int<br>|erventiongroup<br>|by screening <br>|round.<br>|
|---|---|---|---|---|---|---|---|
|**IST Round**|**Season**|**Study**<br>**children**<sup>**a**</sup>|**N (%)**<br>**Screened**|**N (%) RDT**<br>**Positive**|**N (%)**<br>**Treated**|**N (%)**<br>**Supervised**<br>**treatment**<sup>**b**</sup>|**RDT**<br>**sensitivity**<br>**/specificity**<sup>**c**</sup>|
|Feb-Mar 2010|Dry|2674 (98.7)|2454 (91.8)|453 (18.5)|449 (99.1)|435 (96.9)|78.5 / 90.6|
|Jun-Jul 2010|Wet|2654 (97.9)|2430 (91.6)|466 (19.2)|465 (99.8)|440 (94.6)|89.2 / 90.4|
|Sept 2010|Wet|2651 (97.8)|2368 (89.3)|444 (18.8)|443 (99.8)|422 (95.3)|94.6 / 90.3|
|Feb-Mar 2011|Dry|2631 (97.1)|2291 (87.1)|340 (14.8)|335 (98.5)|306 (91.3)|68.7 / 91.9|
|Oct 2011|Wet|2621 (96.7)|2157 (82.3)|345 (16.0)|338 (98.0)|276 (81.7)|NA|
|**TOTALS**||**13231**|**11700 (88.4)**|**2048 (17.5)**|**2030 (99.1)**|**1879 (92.6)**|**82.7 / 90.8**|

sensitivity and specificity of RDTs compared to expert microscopy is displayed a Study children are shown as a percentage of the 2710 initially eligible for the intervention and loss at each stage represents withdrawals and/or deaths. Child transfer events are not included.

> b Children treated who were directly observed taking doses 1,3 and 5 in school at the correct time and who reported taking the evening doses. c  Microscopy results not available for visit 5

21