Is taking Remicade infusion to treat ankylosing spondylitis safe? What are the chances of getting cured by taking Remicade? My beloved girlfriend has a leg disease, the minor type of ankylosing spondylitis, which causes her left knee to feel pain, especially when the weather turns cold. She has to give up her favorite sport of running and she is annoyed with this. What can I do to get her out of this? Should she take up another sport?