paragraph_text: The dominant explanation for the Black Death is the plague theory, which attributes the outbreak to Yersinia pestis, also responsible for an epidemic that began in southern China in 1865, eventually spreading to India. The investigation of the pathogen that caused the 19th-century plague was begun by teams of scientists who visited Hong Kong in 1894, among whom was the French-Swiss bacteriologist Alexandre Yersin, after whom the pathogen was named Yersinia pestis. The mechanism by which Y. pestis was usually transmitted was established in 1898 by Paul-Louis Simond and was found to involve the bites of fleas whose midguts had become obstructed by replicating Y. pestis several days after feeding on an infected host. This blockage results in starvation and aggressive feeding behaviour by the fleas, which repeatedly attempt to clear their blockage by regurgitation, resulting in thousands of plague bacteria being flushed into the feeding site, infecting the host. The bubonic plague mechanism was also dependent on two populations of rodents: one resistant to the disease, which act as hosts, keeping the disease endemic, and a second that lack resistance. When the second population dies, the fleas move on to other hosts, including people, thus creating a human epidemic.

paragraph_text: The river has its sources in the eastern part of Belgorod Oblast, on the southeastern slopes of the Central Russian Upland. It flows in a northeasterly direction, and joins the Don some west of the town of Liski in Voronezh Oblast.

paragraph_text: The results of the Haensch study have since been confirmed and amended. Based on genetic evidence derived from Black Death victims in the East Smithfield burial site in England, Schuenemann et al. concluded in 2011 "that the Black Death in medieval Europe was caused by a variant of Y. pestis that may no longer exist." A study published in Nature in October 2011 sequenced the genome of Y. pestis from plague victims and indicated that the strain that caused the Black Death is ancestral to most modern strains of the disease.

paragraph_text: The disease may have travelled along the Silk Road with Mongol armies and traders or it could have come via ship. By the end of 1346, reports of plague had reached the seaports of Europe: ``India was depopulated, Tartary, Mesopotamia, Syria, Armenia were covered with dead bodies ''.

paragraph_text: The Black Death is thought to have originated in the arid plains of Central Asia, where it then travelled along the Silk Road, reaching Crimea by 1343. From there, it was most likely carried by Oriental rat fleas living on the black rats that were regular passengers on merchant ships. Spreading throughout the Mediterranean and Europe, the Black Death is estimated to have killed 30–60% of Europe's total population. In total, the plague reduced the world population from an estimated 450 million down to 350–375 million in the 14th century. The world population as a whole did not recover to pre-plague levels until the 17th century. The plague recurred occasionally in Europe until the 19th century.

paragraph_text: During the first half of 1349 the Black Death spread northwards. A second front opened up when the plague arrived by ship at the Humber, wherefrom it spread both south and north. In May it reached York, and during the summer months of June, July and August, it ravaged the north. Certain northern counties, like Durham and Cumberland, had been the victim of violent incursions from the Scots, and were therefore left particularly vulnerable to the devastations of the plague. Pestilence is less virulent during the winter months, and spreads less rapidly. The Black Death in England had survived the winter of 1348 -- 49, but during the following winter it gave in, and by December 1349 conditions were returning to relative normalcy. It had taken the disease approximately 500 days to traverse the entire country.

paragraph_text: The Battle of the Tanais River in 373 AD between the Huns and the Alans, was fought on the traditional border between Asia and Europe. The Huns were victorious.

paragraph_text: Gibbs Point, a rock point on the Antarctic Peninsula, the most northern area of the continent of Antarctica, was named for African American Antarctic explorer, George W. Gibbs, Jr. on September 2, 2009. On that date, the Advisory Committee on Antarctic Names (U.S. Board on Geographic Names) confirmed the place name in Antarctica for Gibbs as the first black explorer to set foot on the continent. Gibbs Point is a rock point forming the northwest entrance to Gaul Cove, on the northeast of Horseshoe Island, Marguerite Bay, Antarctic Peninsula.

paragraph_text: The Great Plague of Vienna occurred in 1679 in Vienna, Austria, the imperial residence of the Austrian Habsburg rulers. From contemporary descriptions, the disease is believed to have been bubonic plague, which is caused by the bacterium "Yersinia pestis", carried by fleas associated with the black rat and other rodents. The city was crippled by the epidemic, which recurred fitfully into the early 1680s, claiming an estimated 76,000 residents.

paragraph_text: The plague disease, caused by Yersinia pestis, is enzootic (commonly present) in populations of fleas carried by ground rodents, including marmots, in various areas including Central Asia, Kurdistan, Western Asia, Northern India and Uganda. Nestorian graves dating to 1338–39 near Lake Issyk Kul in Kyrgyzstan have inscriptions referring to plague and are thought by many epidemiologists to mark the outbreak of the epidemic, from which it could easily have spread to China and India. In October 2010, medical geneticists suggested that all three of the great waves of the plague originated in China. In China, the 13th century Mongol conquest caused a decline in farming and trading. However, economic recovery had been observed at the beginning of the 14th century. In the 1330s a large number of natural disasters and plagues led to widespread famine, starting in 1331, with a deadly plague arriving soon after. Epidemics that may have included plague killed an estimated 25 million Chinese and other Asians during the 15 years before it reached Constantinople in 1347.

paragraph_text: The Ordovician Period started at a major extinction event called the Cambrian-Ordovician extinction events some time about 485.4 ± 1.9 Ma. During the Ordovician the southern continents were collected into a single continent called Gondwana. Gondwana started the period in the equatorial latitudes and, as the period progressed, drifted toward the South Pole. Early in the Ordovician the continents Laurentia, Siberia and Baltica were still independent continents (since the break-up of the supercontinent Pannotia earlier), but Baltica began to move toward Laurentia later in the period, causing the Iapetus Ocean to shrink between them. Also, Avalonia broke free from Gondwana and began to head north toward Laurentia. The Rheic Ocean was formed as a result of this. By the end of the period, Gondwana had neared or approached the pole and was largely glaciated.

paragraph_text: In 1466, perhaps 40,000 people died of the plague in Paris. During the 16th and 17th centuries, the plague was present in Paris around 30 per cent of the time. The Black Death ravaged Europe for three years before it continued on into Russia, where the disease was present somewhere in the country 25 times between 1350 to 1490. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years. Over 10% of Amsterdam's population died in 1623–25, and again in 1635–36, 1655, and 1664. Plague occurred in Venice 22 times between 1361 and 1528. The plague of 1576–77 killed 50,000 in Venice, almost a third of the population. Late outbreaks in central Europe included the Italian Plague of 1629–1631, which is associated with troop movements during the Thirty Years' War, and the Great Plague of Vienna in 1679. Over 60% of Norway's population died in 1348–50. The last plague outbreak ravaged Oslo in 1654.

paragraph_text: The Black Death was one of the most devastating pandemics in human history, resulting in the deaths of an estimated 75 to 200 million people in Eurasia and peaking in Europe from 1346 to 1353. The bacterium Yersinia pestis, resulting in several forms of plague, is believed to have been the cause. The plague created a series of religious, social, and economic upheavals, which had profound effects on the course of European history.

paragraph_text: Paddys River, a watercourse of the Murray catchment within the Murray–Darling basin, is located in the Australian Alpine region of New South Wales, Australia.

paragraph_text: In the first half of the 17th century, a plague claimed some 1.7 million victims in Italy, or about 14% of the population. In 1656, the plague killed about half of Naples' 300,000 inhabitants. More than 1.25 million deaths resulted from the extreme incidence of plague in 17th-century Spain. The plague of 1649 probably reduced the population of Seville by half. In 1709–13, a plague epidemic that followed the Great Northern War (1700–21, Sweden v. Russia and allies) killed about 100,000 in Sweden, and 300,000 in Prussia. The plague killed two-thirds of the inhabitants of Helsinki, and claimed a third of Stockholm's population. Europe's last major epidemic occurred in 1720 in Marseille.

paragraph_text: Wallingat River, a watercourse of the Mid-Coast Council system, is located in the Mid North Coast district of New South Wales, Australia.

paragraph_text: Barcoongere River, a watercourse of the Wooli Wooli River catchment, is located in the Northern Rivers region of New South Wales, Australia.

paragraph_text: Primary teeth start to form during the embryo phase of pregnancy. The development of primary teeth starts at the sixth week of tooth development as the dental lamina. This process starts at the midline and then spreads back into the posterior region. By the time the embryo is eight weeks old, there are ten buds on the upper and lower arches that will eventually become the primary (deciduous) dentition. These teeth will continue to form until they erupt in the mouth. In the primary dentition there are a total of twenty teeth: five per quadrant and ten per arch. The eruption of these teeth (``teething '') begins at the age of six months and continues until twenty - five to thirty - three months of age during the primary dentition period. Usually, the first teeth seen in the mouth are the mandibular centrals and the last are the maxillary second molars.

paragraph_text: The Black Death was a pneumonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the Second Pandemic, caused by Yersinia pestis bacteria. The term ``Black Death ''was not used until the late 17th century.

paragraph_text: The story, illustrated by the author, is set in England during the Middle Ages, as the Black Death (bubonic plague) is sweeping across the country. Young Robin is sent away to become a knight like his father, but his dreams are endangered when he loses the use of his legs. A doctor reassures Robin that the weakness in his legs is not caused by the plague and the doctor is supposed to come and help him but does not. His parents are away, serving the king and queen during war, and the servants abandon the house, fearing the plague. Robin is saved by Brother Luke, a friar, who finds him and takes him to a monastery and cares for him.

Question: When did the Black Plague start on the continent that has the river with the Tikhaya Sosna as its mouth?
Answer: By the end of 1346