paragraph_text: The results of the Haensch study have since been confirmed and amended. Based on genetic evidence derived from Black Death victims in the East Smithfield burial site in England, Schuenemann et al. concluded in 2011 "that the Black Death in medieval Europe was caused by a variant of Y. pestis that may no longer exist." A study published in Nature in October 2011 sequenced the genome of Y. pestis from plague victims and indicated that the strain that caused the Black Death is ancestral to most modern strains of the disease.

paragraph_text: Science and technology in Wallonia, the southern region of Belgium (Europe), is well developed with the presence of several universities and research institutes.

paragraph_text: The Black Death was a pneumonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the Second Pandemic, caused by Yersinia pestis bacteria. The term ``Black Death ''was not used until the late 17th century.

paragraph_text: The gare de Laifour is a TER railway station in Laifour, France, in the Ardennes département. The station is served by regional trains of the TER Champagne-Ardenne on the line from Charleville-Mézières to Givet. There is no ticket machine.

paragraph_text: The first European epidemic of the bubonic plague dates back to the mid 6th century and is called the Plague of Justinian. The largest plague epidemic was the Black Death in Europe in the 14th century. In medieval times, the large loss of people (due to the bubonic plague) in a town created an economic disaster. Community plague doctors were quite valuable and were given special privileges; for example, plague doctors were freely allowed to perform autopsies, which were otherwise generally forbidden in Medieval Europe, to research a cure for the plague.In some cases, plague doctors were so valuable that when Barcelona dispatched two to Tortosa in 1650, outlaws captured them en route and demanded a ransom. The city of Barcelona paid for their release. The city of Orvieto hired Matteo fu Angelo in 1348 for four times the normal rate of a doctor of 50-florin per year. Pope Clement VI hired several extra plague doctors during the Black Death plague. They were to attend to the sick people of Avignon. Of 18 doctors in Venice, only one was left by 1348: five had died of the plague, and 12 were missing and may have fled.

paragraph_text: The Great Plague of Vienna occurred in 1679 in Vienna, Austria, the imperial residence of the Austrian Habsburg rulers. From contemporary descriptions, the disease is believed to have been bubonic plague, which is caused by the bacterium "Yersinia pestis", carried by fleas associated with the black rat and other rodents. The city was crippled by the epidemic, which recurred fitfully into the early 1680s, claiming an estimated 76,000 residents.

paragraph_text: The story, illustrated by the author, is set in England during the Middle Ages, as the Black Death (bubonic plague) is sweeping across the country. Young Robin is sent away to become a knight like his father, but his dreams are endangered when he loses the use of his legs. A doctor reassures Robin that the weakness in his legs is not caused by the plague and the doctor is supposed to come and help him but does not. His parents are away, serving the king and queen during war, and the servants abandon the house, fearing the plague. Robin is saved by Brother Luke, a friar, who finds him and takes him to a monastery and cares for him.

paragraph_text: In 1466, perhaps 40,000 people died of the plague in Paris. During the 16th and 17th centuries, the plague was present in Paris around 30 per cent of the time. The Black Death ravaged Europe for three years before it continued on into Russia, where the disease was present somewhere in the country 25 times between 1350 to 1490. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years. Over 10% of Amsterdam's population died in 1623–25, and again in 1635–36, 1655, and 1664. Plague occurred in Venice 22 times between 1361 and 1528. The plague of 1576–77 killed 50,000 in Venice, almost a third of the population. Late outbreaks in central Europe included the Italian Plague of 1629–1631, which is associated with troop movements during the Thirty Years' War, and the Great Plague of Vienna in 1679. Over 60% of Norway's population died in 1348–50. The last plague outbreak ravaged Oslo in 1654.

paragraph_text: The disease may have travelled along the Silk Road with Mongol armies and traders or it could have come via ship. By the end of 1346, reports of plague had reached the seaports of Europe: ``India was depopulated, Tartary, Mesopotamia, Syria, Armenia were covered with dead bodies ''.

paragraph_text: The Black Death was one of the most devastating pandemics in human history, resulting in the deaths of an estimated 75 to 200 million people in Eurasia and peaking in Europe from 1346 to 1353. The bacterium Yersinia pestis, resulting in several forms of plague, is believed to have been the cause. The plague created a series of religious, social, and economic upheavals, which had profound effects on the course of European history.

paragraph_text: Team Number of wins Notes Most recent Western Province 34 Four shared 2017 Northern Transvaal / Blue Bulls 23 Four shared 2009 Transvaal / Gauteng Lions / Golden Lions 11 One shared 2015 Natal / Sharks 7 2013 Orange Free State / Free State Cheetahs 5 One shared 2016 Griqualand West / Griquas 1970 Border / Border Bulldogs Two shared 1934

paragraph_text: The unofficial flag of Bequia is composed of three black waves, which stand for Bequia Channel, the Caribbean Sea and the Atlantic Ocean; and a black humpback whale, Bequia's main icon, surrounded by a black-and-white border around the flag.

paragraph_text: Bollinger () is a Champagne house, a producer of sparkling wines from the Champagne region of France. They produce several labels of Champagne under the Bollinger name, including the vintage "Vieilles Vignes Françaises, Grande Année" and "R.D." as well as the non-vintage Special Cuvée. Founded in 1829 in Aÿ by Hennequin de Villermont, Paul Renaudin and Jacques Bollinger the house continues to be run by members of the Bollinger family. In Britain Bollinger Champagnes are affectionately known as "Bolly".

paragraph_text: The Ordovician Period started at a major extinction event called the Cambrian-Ordovician extinction events some time about 485.4 ± 1.9 Ma. During the Ordovician the southern continents were collected into a single continent called Gondwana. Gondwana started the period in the equatorial latitudes and, as the period progressed, drifted toward the South Pole. Early in the Ordovician the continents Laurentia, Siberia and Baltica were still independent continents (since the break-up of the supercontinent Pannotia earlier), but Baltica began to move toward Laurentia later in the period, causing the Iapetus Ocean to shrink between them. Also, Avalonia broke free from Gondwana and began to head north toward Laurentia. The Rheic Ocean was formed as a result of this. By the end of the period, Gondwana had neared or approached the pole and was largely glaciated.

paragraph_text: The Stock Market Crash of 1929 is often cited as the beginning of the Great Depression. It began on October 24, 1929, and was the most devastating stock market crash in the history of the United States. A lot of the stock market crash can be blamed on over exuberance and false expectations. In the years leading up to 1929, the stock market offered the potential for making huge gains in wealth. As share prices rose, people started to borrow money to invest in the stock market. However, on October 24 (Black Thursday), share prices began to fall and panic selling caused prices to fall sharply. On October 29 (Black Tuesday), share prices fell by $14 billion in a single day, more than $30 billion in the week. The value that evaporated the week was 10x more than the entire federal budget and more than all of what the U.S. spent on World War I. By 1930 the value of shares had fallen by 90%.

paragraph_text: China shares international borders with 14 sovereign states. In addition, there is a 30 - km border with the special administrative region of Hong Kong, which was a British dependency before 1997, and a 3 km border with Macau, a Portuguese territory until 1999. With a land border of 22,117 kilometres (13,743 mi) in total it also has the longest land border of any country.

paragraph_text: Plague was reportedly first introduced to Europe via Genoese traders at the port city of Kaffa in the Crimea in 1347. After a protracted siege, during which the Mongol army under Jani Beg was suffering from the disease, the army catapulted the infected corpses over the city walls of Kaffa to infect the inhabitants. The Genoese traders fled, taking the plague by ship into Sicily and the south of Europe, whence it spread north. Whether or not this hypothesis is accurate, it is clear that several existing conditions such as war, famine, and weather contributed to the severity of the Black Death.

paragraph_text: The Black Death is thought to have originated in the arid plains of Central Asia, where it then travelled along the Silk Road, reaching Crimea by 1343. From there, it was most likely carried by Oriental rat fleas living on the black rats that were regular passengers on merchant ships. Spreading throughout the Mediterranean and Europe, the Black Death is estimated to have killed 30–60% of Europe's total population. In total, the plague reduced the world population from an estimated 450 million down to 350–375 million in the 14th century. The world population as a whole did not recover to pre-plague levels until the 17th century. The plague recurred occasionally in Europe until the 19th century.

paragraph_text: Champagne in paradiso (Italian for 'Champagne in Paradise') is a 1984 Italian musicarello film directed by Aldo Grimaldi and starring Al Bano and Romina Power. It is the last film of the couple.

paragraph_text: The trees and rivers of the Ardennes provided the charcoal industry assets that enabled the great industrial period of Wallonia in the 18th and 19th centuries, when it was arguably the second great industrial region of the world, after England. The greater region maintained an industrial eminence into the 20th century, after coal replaced charcoal in metallurgy.

Question: When did the black plague start in the continent that contains a city that shares a border with Champagne-Ardenne?
Answer: By the end of 1346