paragraph_text: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.

paragraph_text: The film is set on a plantation in the southern United States, specifically in the state of Georgia, some distance from Atlanta. Although sometimes misinterpreted as taking place before the U.S. Civil War while slavery was still legal in the region, the film takes place during the Reconstruction Era after slavery was abolished. Harris' original Uncle Remus stories were all set after the American Civil War and the abolition of slavery. Harris himself, born in 1848, was a racial reconciliation activist writer and journalist of the Reconstruction Era. The film makes several indirect references to the Reconstruction Era: clothing is in the newer late - Victorian style; Uncle Remus is free to leave the plantation at will; black field hands are sharecroppers, etc.

paragraph_text: Endo was born in Colorado, but spent most of his life living in Hawaii. He enlisted in the United States Army in 1941 and served as a radio operator with an infantry unit in Europe.

paragraph_text: After graduating from Vassar College, Ella Weed became principal of Miss Brown's School for Girls in New York. Annie Nathan Meyer interested her in the effort to establish Barnard College. Weed attracted financial support for the venture, and became the paid chairman of the Academic Committee.

paragraph_text: The Freed Weed is a compilation album by the American indie rock band Sebadoh. It was released by Homestead Records in 1990.

paragraph_text: Weed Country was an American reality television series on the Discovery Channel that premiered on February 20, 2013, during Discovery Channel's programming block titled "Weed Wednesdays". The series followed dealers, growers and patients of the marijuana trade located within the Emerald Triangle, along with the enforcers of the law at the Siskiyou County Sheriff's office.

paragraph_text: Cannabis in Colorado refers to cannabis (legal term marijuana) use and possession in Colorado, United States. The Colorado Amendment 64, which was passed by voters on November 6, 2012, led to legalization in January 2014. The policy has led to cannabis tourism. There are two sets of policies in Colorado relating to cannabis use: those for medicinal cannabis and for recreational drug use along with a third set of rules governing hemp.

paragraph_text: Alfred Lewis Enoch (born 2 December 1988) is an English actor, best known for portraying Dean Thomas in the Harry Potter series of films and Wes Gibbins in the ABC legal drama How to Get Away with Murder.

paragraph_text: The Garden of Weeds is a lost 1924 silent film drama directed by James Cruze and starring Betty Compson. It is based on a Broadway play, "Garden of Weeds", by Leon Gordon and Doris Marquette. Famous Players-Lasky produced and Paramount Pictures distributed.

paragraph_text: The Qur'an relates detailed narrative accounts of Maryam (Mary) in two places, Qur'an 3:35–47 and 19:16–34. These state beliefs in both the Immaculate Conception of Mary and the Virgin birth of Jesus. The account given in Sura 19 is nearly identical with that in the Gospel according to Luke, and both of these (Luke, Sura 19) begin with an account of the visitation of an angel upon Zakariya (Zecharias) and Good News of the birth of Yahya (John), followed by the account of the annunciation. It mentions how Mary was informed by an angel that she would become the mother of Jesus through the actions of God alone.

paragraph_text: Cannabis in California is permitted, subject to regulations, for both medical and recreational use. In recent decades the state has led the country in efforts to legalize cannabis, holding the first (unsuccessful) vote to decriminalize it in 1972 and, through Proposition 215, becoming the first state to legalize it for medical use in 1996. In the November 2016 election, voters passed an amendment legalizing recreational use of marijuana.

paragraph_text: The legal history of cannabis in the United States began with state - level prohibition in the early 20th century, with the first major federal limitations occurring in 1937. Starting with Oregon in 1973, individual states began to liberalize cannabis laws through decriminalization. In 1996, California became the first state to legalize medical cannabis, sparking a trend that spread to a majority of states by 2016. In 2012, Colorado and Washington became the first states to legalize cannabis for recreational use.

paragraph_text: Gateway National Recreation Area contains over 26,000 acres (10,521.83 ha) in total, most of it surrounded by New York City, including the Jamaica Bay Wildlife Refuge in Brooklyn and Queens, over 9,000 acres (36 km2) of salt marsh, islands, and water, including most of Jamaica Bay. Also in Queens, the park includes a significant portion of the western Rockaway Peninsula, most notably Jacob Riis Park and Fort Tilden. In Staten Island, the park includes Fort Wadsworth, with historic pre-Civil War era Battery Weed and Fort Tompkins, and Great Kills Park, with beaches, trails, and a marina.

paragraph_text: Brusilow entered the Curtis Institute of Music when he was eleven and studied there with Efrem Zimbalist. Throughout most of his childhood and adolescence, he was known as "Albert Brusilow". Later, at the urging of his girlfriend (who would later become his wife), he returned to using his birth name, Anshel.

paragraph_text: The birth control movement in the United States was a social reform campaign from 1914 to around 1945 that aimed to increase the availability of contraception in the U.S. through education and legalization. The movement began in 1914 when a group of political radicals in New York City, led by Emma Goldman, Mary Dennett, and Margaret Sanger, became concerned about the hardships that childbirth and self - induced abortions brought to low - income women. Sanger, in particular, simultaneously sought to connect birth control to the organized eugenics movement, regularly appealing to the authority of eugenic scientists Karl Pearson, Charles Davenport, and others in her Birth Control Review from the early 1920s Such figures sought to prevent population segments they deemed genetically 'undesirable' from reproducing. While seeking legitimacy for the birth control movement partly through the approval of organized eugenics, Sanger and other activists also worked on the political front. Since contraception was considered to be obscene at the time, the activists targeted the Comstock laws, which prohibited distribution of any ``obscene, lewd, and / or lascivious ''materials through the mail. Hoping to provoke a favorable legal decision, Sanger deliberately broke the law by distributing The Woman Rebel, a newsletter containing a discussion of contraception. In 1916, Sanger opened the first birth control clinic in the United States, but the clinic was immediately shut down by police, and Sanger was sentenced to 30 days in jail.

paragraph_text: Lake Petersburg is a census-designated place in Menard County, Illinois, United States. Its population was 719 as of the 2010 census. The unincorporated community centers on a small reservoir, which is used extensively by residents for recreation.

paragraph_text: Alfred Lewis Enoch (born 2 December 1988) is an English actor who portrayed Dean Thomas in the Harry Potter films and Wes Gibbins in the ABC legal drama How to Get Away with Murder.

paragraph_text: The Douglass Township Community Building is a community recreational auditorium and sports facility constructed in 1936, in Douglass, Kansas. It was designed by architect J. Hamilton. It was added to the National Register of Historic Places in 1995.

paragraph_text: The Slocan Valley Rail Trail is a multi-use recreational rail trail located in the Kootenay region of southeastern British Columbia, namely the Slocan Valley.

paragraph_text: John Cho as Harold Lee, a second generation Korean - American man working at his first job in investment banking. Kal Penn as Kumar Patel, a second generation Indian - American whose family thinks that he will become a doctor like his father and brother. Paula Garcés as Maria Perez, Harold and Kumar's neighbor, on whom Harold has a crush. Neil Patrick Harris as a fictionalized version of himself. Ryan Reynolds as an OR nurse David Krumholtz as Goldstein, Harold and Kumar's neighbor and Rosenberg's roommate Eddie Kaye Thomas as Rosenberg, Harold and Kumar's neighbor and Goldstein's roommate Brooke D'Orsay as Clarissa, twin sister student at Princeton University who agreed to smoke weed with Kumar Kate Kelton as Chrissy, twin sister student at Princeton University who agreed to smoke weed with Kumar Christopher Meloni as Randy / Freakshow, a car mechanic with infected pimples on his face and neck who fixed Harold and Kumar's car Sandy Jobin Bevans as Officer Palumbo, a police officer Fred Willard as Dr. Willoughby, medical school dean who interviewed Kumar Robert Tinkler as J.D. Anthony Anderson as the Burger Shack Employee Siu Ta as Cindy Kim, student at Princeton University who has a crush on Harold Malin Åkerman as Liane, Freakshow's wife Dov Tiefenbach as Bradley Thomas, student at Princeton University who sold weed to Kumar Gary Anthony Williams as Tarik Jackson, a philosophical black man in who has been arrested for being black Gary Archibald as Nathaniel Brooks Craig Stevens as Ralph Jamie Kennedy as Creepy Guy (uncredited) Ethan Embry as Billy Carver

Question: When did weed become legal for recreational use in the birth state of Harry Endo?
Answer: January 2014