paragraph_text: People began to be alarmed. Samuel Pepys, who had an important position at the Admiralty, stayed in London and provided a contemporary account of the plague through his diary. On 30 April he wrote: ``Great fears of the sickness here in the City it being said that two or three houses are already shut up. God preserve us all! ''Another source of information on the time is a fictional account, A Journal of the Plague Year, which was written by Daniel Defoe and published in 1722. He had been only six when the plague struck but made use of his family's recollections (his uncle was a saddler in East London and his father a butcher in Cripplegate), interviews with survivors and sight of such official records as were available.

paragraph_text: In 1466, perhaps 40,000 people died of the plague in Paris. During the 16th and 17th centuries, the plague was present in Paris around 30 per cent of the time. The Black Death ravaged Europe for three years before it continued on into Russia, where the disease was present somewhere in the country 25 times between 1350 to 1490. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years. Over 10% of Amsterdam's population died in 1623–25, and again in 1635–36, 1655, and 1664. Plague occurred in Venice 22 times between 1361 and 1528. The plague of 1576–77 killed 50,000 in Venice, almost a third of the population. Late outbreaks in central Europe included the Italian Plague of 1629–1631, which is associated with troop movements during the Thirty Years' War, and the Great Plague of Vienna in 1679. Over 60% of Norway's population died in 1348–50. The last plague outbreak ravaged Oslo in 1654.

paragraph_text: Around 1300, centuries of prosperity and growth in Europe came to a halt. A series of famines and plagues, including the Great Famine of 1315–1317 and the Black Death, reduced the population to around half of what it was before the calamities. Along with depopulation came social unrest and endemic warfare. France and England experienced serious peasant uprisings, such as the Jacquerie and the Peasants' Revolt, as well as over a century of intermittent conflict in the Hundred Years' War. To add to the many problems of the period, the unity of the Catholic Church was shattered by the Western Schism. Collectively these events are sometimes called the Crisis of the Late Middle Ages.

paragraph_text: In England, in the absence of census figures, historians propose a range of preincident population figures from as high as 7 million to as low as 4 million in 1300, and a postincident population figure as low as 2 million. By the end of 1350, the Black Death subsided, but it never really died out in England. Over the next few hundred years, further outbreaks occurred in 1361–62, 1369, 1379–83, 1389–93, and throughout the first half of the 15th century. An outbreak in 1471 took as much as 10–15% of the population, while the death rate of the plague of 1479–80 could have been as high as 20%. The most general outbreaks in Tudor and Stuart England seem to have begun in 1498, 1535, 1543, 1563, 1589, 1603, 1625, and 1636, and ended with the Great Plague of London in 1665.

paragraph_text: The plague disease, caused by Yersinia pestis, is enzootic (commonly present) in populations of fleas carried by ground rodents, including marmots, in various areas including Central Asia, Kurdistan, Western Asia, Northern India and Uganda. Nestorian graves dating to 1338–39 near Lake Issyk Kul in Kyrgyzstan have inscriptions referring to plague and are thought by many epidemiologists to mark the outbreak of the epidemic, from which it could easily have spread to China and India. In October 2010, medical geneticists suggested that all three of the great waves of the plague originated in China. In China, the 13th century Mongol conquest caused a decline in farming and trading. However, economic recovery had been observed at the beginning of the 14th century. In the 1330s a large number of natural disasters and plagues led to widespread famine, starting in 1331, with a deadly plague arriving soon after. Epidemics that may have included plague killed an estimated 25 million Chinese and other Asians during the 15 years before it reached Constantinople in 1347.

paragraph_text: The Black Death is thought to have originated in the arid plains of Central Asia, where it then travelled along the Silk Road, reaching Crimea by 1343. From there, it was most likely carried by Oriental rat fleas living on the black rats that were regular passengers on merchant ships. Spreading throughout the Mediterranean and Europe, the Black Death is estimated to have killed 30–60% of Europe's total population. In total, the plague reduced the world population from an estimated 450 million down to 350–375 million in the 14th century. The world population as a whole did not recover to pre-plague levels until the 17th century. The plague recurred occasionally in Europe until the 19th century.

paragraph_text: Approximately one-third of East Prussia's population died in the plague and famine of 1709–1711, including the last speakers of Old Prussian. The plague, probably brought by foreign troops during the Great Northern War, killed 250,000 East Prussians, especially in the province's eastern regions. Crown Prince Frederick William I led the rebuilding of East Prussia, founding numerous towns. Thousands of Protestants expelled from the Archbishopric of Salzburg were allowed to settle in depleted East Prussia. The province was overrun by Imperial Russian troops during the Seven Years' War.

paragraph_text: What a Crazy World is a 1963 film directed by Michael Carreras from a script by Carreras and Alan Klein, from the latter's stage play. It is a pop musical featuring a number of late 1950s and early 1960s pop acts, including an appearance by Freddie and the Dreamers.

paragraph_text: The story, illustrated by the author, is set in England during the Middle Ages, as the Black Death (bubonic plague) is sweeping across the country. Young Robin is sent away to become a knight like his father, but his dreams are endangered when he loses the use of his legs. A doctor reassures Robin that the weakness in his legs is not caused by the plague and the doctor is supposed to come and help him but does not. His parents are away, serving the king and queen during war, and the servants abandon the house, fearing the plague. Robin is saved by Brother Luke, a friar, who finds him and takes him to a monastery and cares for him.

paragraph_text: During the first half of 1349 the Black Death spread northwards. A second front opened up when the plague arrived by ship at the Humber, wherefrom it spread both south and north. In May it reached York, and during the summer months of June, July and August, it ravaged the north. Certain northern counties, like Durham and Cumberland, had been the victim of violent incursions from the Scots, and were therefore left particularly vulnerable to the devastations of the plague. Pestilence is less virulent during the winter months, and spreads less rapidly. The Black Death in England had survived the winter of 1348 -- 49, but during the following winter it gave in, and by December 1349 conditions were returning to relative normalcy. It had taken the disease approximately 500 days to traverse the entire country.

paragraph_text: The first European epidemic of the bubonic plague dates back to the mid 6th century and is called the Plague of Justinian. The largest plague epidemic was the Black Death in Europe in the 14th century. In medieval times, the large loss of people (due to the bubonic plague) in a town created an economic disaster. Community plague doctors were quite valuable and were given special privileges; for example, plague doctors were freely allowed to perform autopsies, which were otherwise generally forbidden in Medieval Europe, to research a cure for the plague.In some cases, plague doctors were so valuable that when Barcelona dispatched two to Tortosa in 1650, outlaws captured them en route and demanded a ransom. The city of Barcelona paid for their release. The city of Orvieto hired Matteo fu Angelo in 1348 for four times the normal rate of a doctor of 50-florin per year. Pope Clement VI hired several extra plague doctors during the Black Death plague. They were to attend to the sick people of Avignon. Of 18 doctors in Venice, only one was left by 1348: five had died of the plague, and 12 were missing and may have fled.

paragraph_text: Aline Brosh McKenna (born August 2, 1967) is an American screenwriter, producer and director. She is known for writing "The Devil Wears Prada" (2006), "27 Dresses" (2008), "Morning Glory" (2010) and "We Bought a Zoo" (2011), and for co-creating The CW's "Crazy Ex-Girlfriend".

paragraph_text: Plague was reportedly first introduced to Europe via Genoese traders at the port city of Kaffa in the Crimea in 1347. After a protracted siege, during which the Mongol army under Jani Beg was suffering from the disease, the army catapulted the infected corpses over the city walls of Kaffa to infect the inhabitants. The Genoese traders fled, taking the plague by ship into Sicily and the south of Europe, whence it spread north. Whether or not this hypothesis is accurate, it is clear that several existing conditions such as war, famine, and weather contributed to the severity of the Black Death.

paragraph_text: In the first half of the 17th century, a plague claimed some 1.7 million victims in Italy, or about 14% of the population. In 1656, the plague killed about half of Naples' 300,000 inhabitants. More than 1.25 million deaths resulted from the extreme incidence of plague in 17th-century Spain. The plague of 1649 probably reduced the population of Seville by half. In 1709–13, a plague epidemic that followed the Great Northern War (1700–21, Sweden v. Russia and allies) killed about 100,000 in Sweden, and 300,000 in Prussia. The plague killed two-thirds of the inhabitants of Helsinki, and claimed a third of Stockholm's population. Europe's last major epidemic occurred in 1720 in Marseille.

paragraph_text: Around 1300–1350 the Medieval Warm Period gave way to the Little Ice Age. The colder climate resulted in agricultural crises, the first of which is known as the Great Famine of 1315-1317. The demographic consequences of this famine, however, were not as severe as the plagues that occurred later in the century, particularly the Black Death. Estimates of the death rate caused by this epidemic range from one third to as much as sixty percent. By around 1420, the accumulated effect of recurring plagues and famines had reduced the population of Europe to perhaps no more than a third of what it was a century earlier. The effects of natural disasters were exacerbated by armed conflicts; this was particularly the case in France during the Hundred Years' War.

paragraph_text: The Black Death was a pneumonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the Second Pandemic, caused by Yersinia pestis bacteria. The term ``Black Death ''was not used until the late 17th century.

paragraph_text: The results of the Haensch study have since been confirmed and amended. Based on genetic evidence derived from Black Death victims in the East Smithfield burial site in England, Schuenemann et al. concluded in 2011 "that the Black Death in medieval Europe was caused by a variant of Y. pestis that may no longer exist." A study published in Nature in October 2011 sequenced the genome of Y. pestis from plague victims and indicated that the strain that caused the Black Death is ancestral to most modern strains of the disease.

paragraph_text: "The Needle and the Damage Done" is a song by Neil Young that describes the destruction caused by the heroin addiction of musicians he knew including his friend and Crazy Horse bandmate Danny Whitten. It previews the theme of the "Tonight's the Night" album that reflects Young's grief over the heroin overdose and death of both Whitten and Bruce Berry, a roadie for Young and Crazy Horse.

paragraph_text: The Black Death was one of the most devastating pandemics in human history, resulting in the deaths of an estimated 75 to 200 million people in Eurasia and peaking in Europe from 1346 to 1353. The bacterium Yersinia pestis, resulting in several forms of plague, is believed to have been the cause. The plague created a series of religious, social, and economic upheavals, which had profound effects on the course of European history.

paragraph_text: Michael Carreras (21 December 1927, in London – 19 April 1994, in London) was a British film producer and director. He was known for his association with Hammer Studios, being the son of founder James Carreras, and taking an executive role in the company during its most successful years.

Question: When was the Great Plague in the city where the director of What a Crazy World died?
Answer: 1665