paragraph_text: The plague theory was first significantly challenged by the work of British bacteriologist J. F. D. Shrewsbury in 1970, who noted that the reported rates of mortality in rural areas during the 14th-century pandemic were inconsistent with the modern bubonic plague, leading him to conclude that contemporary accounts were exaggerations. In 1984 zoologist Graham Twigg produced the first major work to challenge the bubonic plague theory directly, and his doubts about the identity of the Black Death have been taken up by a number of authors, including Samuel K. Cohn, Jr. (2002), David Herlihy (1997), and Susan Scott and Christopher Duncan (2001).

paragraph_text: The Late Middle Ages spanned the 14th and early 15th centuries. Around 1300, centuries of European prosperity and growth came to a halt. A series of famines and plagues, such as the Great Famine of 1315–1317 and the Black Death, killed people in a matter of days, reducing the population of some areas by half as many survivors fled. Kishlansky reports:

paragraph_text: The 2010 Elazığ earthquake was a 6.1 M earthquake that occurred on 8 March 2010 at 02:32 UTC (04:32 local time). The epicentre was Başyurt in Elazığ Province, in eastern Turkey. Initial reports in global media said as many as 57 people had died. By 10 March, reports in the Turkish media placed the death toll at 41 and later, the death toll rose to 42. Another 74 were injured, many after falling and jumping from buildings. A stampede through the streets led to further injuries.

paragraph_text: In addition to arguing that the rat population was insufficient to account for a bubonic plague pandemic, sceptics of the bubonic plague theory point out that the symptoms of the Black Death are not unique (and arguably in some accounts may differ from bubonic plague); that transference via fleas in goods was likely to be of marginal significance; and that the DNA results may be flawed and might not have been repeated elsewhere, despite extensive samples from other mass graves. Other arguments include the lack of accounts of the death of rats before outbreaks of plague between the 14th and 17th centuries; temperatures that are too cold in northern Europe for the survival of fleas; that, despite primitive transport systems, the spread of the Black Death was much faster than that of modern bubonic plague; that mortality rates of the Black Death appear to be very high; that, while modern bubonic plague is largely endemic as a rural disease, the Black Death indiscriminately struck urban and rural areas; and that the pattern of the Black Death, with major outbreaks in the same areas separated by 5 to 15 years, differs from modern bubonic plague—which often becomes endemic for decades with annual flare-ups.

paragraph_text: The historian Francis Aidan Gasquet wrote about the 'Great Pestilence' in 1893 and suggested that "it would appear to be some form of the ordinary Eastern or bubonic plague". He was able to adopt the epidemiology of the bubonic plague for the Black Death for the second edition in 1908, implicating rats and fleas in the process, and his interpretation was widely accepted for other ancient and medieval epidemics, such as the Justinian plague that was prevalent in the Eastern Roman Empire from 541 to 700 CE.

paragraph_text: The Black Death, also known as the Great Plague, the Black Plague, or the Plague, was one of the most devastating pandemics in human history, resulting in the deaths of an estimated 75 to 200 million people in Eurasia and peaking in Europe from 1347 to 1351. The bacterium Yersinia pestis, which results in several forms of plague, is believed to have been the cause. The plague created a series of religious, social and economic upheavals, which had profound effects on the course of European history.

paragraph_text: Acral necrosis is a symptom common in bubonic plague. The striking black discoloration of skin and tissue, primarily on the extremities (``acral ''), is commonly thought to have given rise to the name`` Black Death,'' associated both with the disease and the pandemic which occurred in the 14th century. The term in fact came from the figural sense of ``black '', that is ghastly, lugubrious or dreadful.

paragraph_text: The 2013 Houphouët-Boigny stampede occurred as crowds departed a New Year's Eve fireworks display in the early hours of 1 January 2013 near the Félix Houphouët-Boigny Stadium in Abidjan, Ivory Coast. It resulted in 61 deaths and over 200 injuries, mostly women and children. This was the second time in four years that a fatal stampede occurred at the stadium.

paragraph_text: In 1726, however, a re-establishment took place through Jakob van Schuppen as "K.k. Hofacademie of the painters, sculptor and architecture", which still exists. Peter Strudel is considered as a founder of the oldest art academy of central Europe, the Academy of Fine Arts Vienna. One year before the death of Strudel, the "Strudelhof" included a plague house, where those afflicted by the epidemic were treated and quarantined.

paragraph_text: The Late Middle Ages was marked by difficulties and calamities including famine, plague, and war, which significantly diminished the population of Europe; between 1347 and 1350, the Black Death killed about a third of Europeans. Controversy, heresy, and schism within the Church paralleled the interstate conflict, civil strife, and peasant revolts that occurred in the kingdoms. Cultural and technological developments transformed European society, concluding the Late Middle Ages and beginning the early modern period.

paragraph_text: In 1466, perhaps 40,000 people died of the plague in Paris. During the 16th and 17th centuries, the plague was present in Paris around 30 per cent of the time. The Black Death ravaged Europe for three years before it continued on into Russia, where the disease was present somewhere in the country 25 times between 1350 to 1490. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years. Over 10% of Amsterdam's population died in 1623–25, and again in 1635–36, 1655, and 1664. Plague occurred in Venice 22 times between 1361 and 1528. The plague of 1576–77 killed 50,000 in Venice, almost a third of the population. Late outbreaks in central Europe included the Italian Plague of 1629–1631, which is associated with troop movements during the Thirty Years' War, and the Great Plague of Vienna in 1679. Over 60% of Norway's population died in 1348–50. The last plague outbreak ravaged Oslo in 1654.

paragraph_text: The Black Death, also known as the Great Plague, the Black Plague, or simply the Plague, was one of the most devastating pandemics in human history, resulting in the deaths of an estimated 75 to 200 million people in Eurasia and peaking in Europe from 1347 to 1351. The bacterium Yersinia pestis, which results in several forms of plague, is believed to have been the cause. The plague created a series of religious, social and economic upheavals, which had profound effects on the course of European history.

paragraph_text: The Black Death was a bubonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the Second Pandemic, caused by Yersinia pestis bacteria. The term ``Black Death ''was not used until the late 17th century.

paragraph_text: The Bartolini Salimbeni Annunciation (Italian: "Annunciazione Bartolini Salimbeni") is a painting by the Italian Gothic painter Lorenzo Monaco, completed just before his death (1420–1424) and housed in the Bartolini Salimbeni Chapel of the church of Santa Trinita, Florence, Italy.

paragraph_text: Malchiostro Annunciation is a painting by the Italian Renaissance artist Titian, completed around 1520, and housed in the Cathedral of Treviso, northern Italy.

paragraph_text: Triptych of the Annunciation is a 1483 triptych by the Flemish artist known only as the Master of the Legend of Saint Ursula, located in the Indianapolis Museum of Art, which is in Indianapolis, Indiana. It depicts the Annunciation on the central panel, while the surrounding panels and the outside of the wings are covered in various pairs of male saints.

paragraph_text: The Martyrdom of Saint Lawrence is a 1558 painting by Titian, now in the church of I Gesuiti in Venice. It so impressed Philip II of Spain that he commissioned a second version in 1567 for the basilica at El Escorial.

paragraph_text: Christian Ackermann was born in Königsberg. He worked in Riga, Stockholm, and Gdańsk, before becoming active in Tallinn from about 1672 until his death in 1710. In 1675, Ackermann moved to Tallinn and acquired his own workshop. He probably died either in 1710 or a short time later from plague.

paragraph_text: The Black Death is thought to have originated in the arid plains of Central Asia, where it then travelled along the Silk Road, reaching Crimea by 1343. From there, it was most likely carried by Oriental rat fleas living on the black rats that were regular passengers on merchant ships. Spreading throughout the Mediterranean and Europe, the Black Death is estimated to have killed 30 -- 60% of Europe's total population. In total, the plague may have reduced the world population from an estimated 450 million down to 350 -- 375 million in the 14th century. The world population as a whole did not recover to pre-plague levels until the 17th century. The plague recurred occasionally in Europe until the 19th century.

paragraph_text: It is recognised that an epidemiological account of the plague is as important as an identification of symptoms, but researchers are hampered by the lack of reliable statistics from this period. Most work has been done on the spread of the plague in England, and even estimates of overall population at the start vary by over 100% as no census was undertaken between the time of publication of the Domesday Book and the year 1377. Estimates of plague victims are usually extrapolated from figures from the clergy.

Question: How many times did plague occur in the place of death of the creator of the Malchiostro Annunciation?
Answer: 22