paragraph_text: The spice trade was made possible by the maritime trade route. In 1498, the Portuguese navigator, Vasco da Gama, sailed round the Cape of Good Hope and opened up a sea route from Europe to India. Bringing home samples of exotic oriental products, da Gama greatly increased European interest in the new trade route and the new trade route quickly facilitated the expansion of trade. Eventually, the Dutch wrestled control of it from the Portuguese in the 17th century, and in the 18th century, the British gained control of it from the Dutch. Nevertheless, the spice route greatly increased trading activities, deepened the economic relations between Europe and Southeast Asia and as a result, more European merchants found their way to Southeast Asia.

paragraph_text: With Istanbul as its capital and control of lands around the Mediterranean basin, the Ottoman Empire was at the center of interactions between the Eastern and Western worlds for six centuries. Following a long period of military setbacks against European powers, the Ottoman Empire gradually declined into the late nineteenth century. The empire allied with Germany in the early 20th century, with the imperial ambition of recovering its lost territories, but it dissolved in the aftermath of World War I, leading to the emergence of the new state of Turkey in the Ottoman Anatolian heartland, as well as the creation of modern Balkan and Middle Eastern states, thus ending Turkish colonial ambitions.

paragraph_text: The discovery of new maritime trade routes by Western European states allowed them to avoid the Ottoman trade monopoly. The Portuguese discovery of the Cape of Good Hope in 1488 initiated a series of Ottoman-Portuguese naval wars in the Indian Ocean throughout the 16th century. The Somali Muslim Ajuran Empire, allied with the Ottomans, defied the Portuguese economic monopoly in the Indian Ocean by employing a new coinage which followed the Ottoman pattern, thus proclaiming an attitude of economic independence in regard to the Portuguese.

paragraph_text: The Gallipoli campaign, also known as the Dardanelles campaign, the Battle of Gallipoli or the Battle of Çanakkale (), was a campaign of the First World War that took place on the Gallipoli peninsula (Gelibolu in modern Turkey), from 17 February 1915 to 9 January 1916. The Entente powers, Britain, France and the Russian Empire, sought to weaken the Ottoman Empire, one of the Central Powers, by taking control of the straits that provided a supply route to Russia. The Allies' attack on Ottoman forts at the entrance of the Dardanelles in February 1915 failed and was followed by an amphibious landing on the Gallipoli peninsula in April 1915 to capture the Ottoman capital of Constantinople (Istanbul).

paragraph_text: The economic structure of the Empire was defined by its geopolitical structure. The Ottoman Empire stood between the West and the East, thus blocking the land route eastward and forcing Spanish and Portuguese navigators to set sail in search of a new route to the Orient. The Empire controlled the spice route that Marco Polo once used. When Vasco da Gama bypassed Ottoman controlled routes and established direct trade links with India in 1498, and Christopher Columbus first journeyed to the Bahamas in 1492, the Ottoman Empire was at its zenith.

paragraph_text: Pan-Slavism, a movement which came into prominence in the mid-19th century, emphasized the common heritage and unity of all the Slavic peoples. The main focus was in the Balkans where the South Slavs had been ruled for centuries by other empires: the Byzantine Empire, Austria-Hungary, the Ottoman Empire, and Venice. The Russian Empire used Pan-Slavism as a political tool; as did the Soviet Union, which gained political-military influence and control over most Slavic-majority nations between 1945 and 1948 and retained a hegemonic role until the period 1989–1991.

paragraph_text: The island would serve Britain as a key military base for its colonial routes. By 1906, when the Famagusta harbour was completed, Cyprus was a strategic naval outpost overlooking the Suez Canal, the crucial main route to India which was then Britain's most important overseas possession. Following the outbreak of the First World War and the decision of the Ottoman Empire to join the war on the side of the Central Powers, on 5 November 1914 the British Empire formally annexed Cyprus and declared the Ottoman Khedivate of Egypt and Sudan a Sultanate and British protectorate.

paragraph_text: At the end of the 15th century the Ottoman Empire advanced all over Southeastern Europe, eventually conquering the Byzantine Empire and extending control over the Balkan states. Hungary was the last bastion of the Latin Christian world in the East, and fought to keep its rule over a period of two centuries. After the tragic death of the young king Vladislaus I of Hungary during the Battle of Varna in 1444 against the Ottomans, the Kingdom was placed in the hands of count John Hunyadi, who became Hungary's regent-governor (1446–1453). Hunyadi was considered one of the most relevant military figures of the 15th century: Pope Pius II awarded him the title of Athleta Christi or Champion of Christ for being the only hope of resisting the Ottomans from advancing to Central and Western Europe.

paragraph_text: With Constantinople as its capital and control of lands around the Mediterranean basin, the Ottoman Empire was at the centre of interactions between the Eastern and Western worlds for six centuries. Following a long period of military setbacks against European powers, the Ottoman Empire gradually declined into the late nineteenth century. The empire allied with Germany in the early 20th century, with the imperial ambition of recovering its lost territories, joining in World War I to achieve this ambition on the side of Germany and the Central Powers. While the Empire was able to largely hold its own during the conflict, it was struggling with internal dissent, especially with the Arab Revolt in its Arabian holdings. Starting before the war, but growing increasingly common and violent during it, major atrocities were committed by the Ottoman government against the Armenians, Assyrians and Pontic Greeks. The Empire's defeat and the occupation of part of its territory by the Allied Powers in the aftermath of World War I resulted in the emergence of a new state, Turkey, in the Ottoman Anatolian heartland following the Turkish War of Independence, as well as the founding of modern Balkan and Middle Eastern states and the partitioning of the Ottoman Empire.

paragraph_text: The Ottoman Navy vastly contributed to the expansion of the Empire's territories on the European continent. It initiated the conquest of North Africa, with the addition of Algeria and Egypt to the Ottoman Empire in 1517. Starting with the loss of Greece in 1821 and Algeria in 1830, Ottoman naval power and control over the Empire's distant overseas territories began to decline. Sultan Abdülaziz (reigned 1861–1876) attempted to reestablish a strong Ottoman navy, building the largest fleet after those of Britain and France. The shipyard at Barrow, England, built its first submarine in 1886 for the Ottoman Empire.

paragraph_text: For over 200 years, Russia had been expanding southwards across the sparsely populated "Wild Fields" toward the warm water ports of the Black Sea that did not freeze over like the handful of other ports available in the north. The goal was to promote year-round trade and a year-round navy.:11 Pursuit of this goal brought the emerging Russian state into conflict with the Ukrainian Cossacks and then with the Tatars of the Crimean Khanate and Circassians. When Russia conquered these groups and gained possession of southern Ukraine, known as New Russia during Russian imperial times, the Ottoman Empire lost its buffer zone against Russian expansion, and Russia and the Ottoman Empire fell into direct conflict. The conflict with the Ottoman Empire also presented a religious issue of importance, as Russia saw itself as the protector of Orthodox Christians, many of whom lived under Ottoman control and were treated as second-class citizens.(ch 1)

paragraph_text: Hekimoğlu Ali Pasha (1689 – 13 August 1758) was an Ottoman statesman and military leader who served as Grand Vizier of the Ottoman Empire three times.

paragraph_text: Sarkis Diranian (; 1854 in Constantinople, now Istanbul, Ottoman Empire - 1938 in Paris, France ) was an Armenian orientalist painter. Originally from the Ottoman Empire, he was established for many years in Paris.

paragraph_text: In the Footsteps of Marco Polo is a 2008 PBS documentary film detailing Denis Belliveau and Francis O'Donnell's 1993 retracing of Marco Polo's journey from Venice to Anatolia, Persia, India and China. The movie documents the first quest "to visit and document every region Marco Polo claimed to have traveled" using only land and sea methods of transportation. Mike Hale of "The New York Times" writes that the documentary includes how Belliveau and O'Donnell "encountered Mongol horsemen and hostile Chinese security officers and survived a firefight between Afghan factions. In the spirit of Polo's journey -- and to prove a point regarding the authenticity of his account -- they disdained airplanes, traveling by foot, on horses and camels and by jeep, boat and train." A text by the same name as the video, "In the Footsteps of Marco Polo", written by Belliveau and O'Donnell, and published by Rowman & Littlefield, serves as a companion to the documentary film. "In the Footsteps of Marco Polo" has been used by Belliveau to create a unique interdisciplinary educational curriculum that he presents at schools and libraries across the United States and internationally.

paragraph_text: The Ottoman Empire (/ˈɒtəmən/; Ottoman Turkish: دَوْلَتِ عَلِيّهٔ عُثمَانِیّه‎ Devlet-i Aliyye-i Osmâniyye, Modern Turkish: Osmanlı İmparatorluğu or Osmanlı Devleti), also known as the Turkish Empire, Ottoman Turkey or Turkey, was an empire founded in 1299 by Oghuz Turks under Osman I in northwestern Anatolia. After conquests in the Balkans by Murad I between 1362 and 1389, the Ottoman sultanate was transformed into a transcontinental empire and claimant to the caliphate. The Ottomans ended the Byzantine Empire with the 1453 conquest of Constantinople by Mehmed the Conqueror.

paragraph_text: Cornelis de Houtman (2 April 1565 – 1 September 1599), brother of Frederick de Houtman, was a Dutch explorer who discovered a new sea route from Europe to Indonesia and who thus begun the Dutch spice trade. At the time, the Portuguese Empire held a monopoly on the spice trade, and the voyage was a symbolic victory for the Dutch, even though the voyage itself was a disaster. Houtman was also a spy, having worked against the Portuguese by bringing back to the Netherlands privileged nautical information obtained during his stay in Portugal.

paragraph_text: The Crimean War was a military conflict fought between October 1853 – March 1856 in which Russia lost to an alliance of France, the United Kingdom, the Ottoman Empire, and Sardinia. The immediate cause involved the rights of Christian minorities in the Holy Land, which was controlled by the Ottoman Empire. The French promoted the rights of Catholics, while Russia promoted those of the Eastern Orthodox Christians. The longer-term causes involved the decline of the Ottoman Empire and the unwillingness of the United Kingdom and France to allow Russia to gain territory and power at Ottoman expense. It has widely been noted that the causes, in one case involving an argument over a key, have never revealed a "greater confusion of purpose", yet led to a war noted for its "notoriously incompetent international butchery."

paragraph_text: In 1466, perhaps 40,000 people died of the plague in Paris. During the 16th and 17th centuries, the plague was present in Paris around 30 per cent of the time. The Black Death ravaged Europe for three years before it continued on into Russia, where the disease was present somewhere in the country 25 times between 1350 to 1490. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years. Over 10% of Amsterdam's population died in 1623–25, and again in 1635–36, 1655, and 1664. Plague occurred in Venice 22 times between 1361 and 1528. The plague of 1576–77 killed 50,000 in Venice, almost a third of the population. Late outbreaks in central Europe included the Italian Plague of 1629–1631, which is associated with troop movements during the Thirty Years' War, and the Great Plague of Vienna in 1679. Over 60% of Norway's population died in 1348–50. The last plague outbreak ravaged Oslo in 1654.

paragraph_text: The Battle of Zenta or Battle of Senta, fought on 11 September 1697 just south of Zenta (Serbian: Senta; then part of the Ottoman Empire; today in Serbia), on the east side of the Tisa river, was a major engagement in the Great Turkish War (1683–1699) and one of the most decisive defeats in Ottoman history. In a surprise attack, Habsburg Imperial forces routed the Ottoman army which was crossing the river. At the cost of a few hundred losses, the Habsburg forces inflicted thousands of casualties on the Ottomans, dispersed the remainder and captured the Ottoman treasure. As an immediate consequence, the Ottoman Empire lost control over Banat, while in the long run, the Habsburg victory at Zenta was the last decisive step that forced the Ottoman Empire into the Treaty of Karlowitz (1699), ending the Ottoman control of large parts of Central Europe.

paragraph_text: Dolores Zohrab Liebmann (January 13, 1896 in Istanbul, Ottoman Empire – September 15, 1991 in New York City, US) was an American philanthropist of Armenian descent born in the Ottoman Empire. She established the Dolores Zohrab Liebmann Fund, which distributes fellowships to graduate students.

Question: How many times did plague occur in the birthplace of the person who used the spice route that the Ottoman Empire controlled?
Answer: 22