Juan de la Cerda, 2nd Duke of Medinaceli
Juan de la Cerda, 2nd Duke of Medinaceli, Grandee of Spain, (in full), (1485 – 20 January 1544) was a Spanish nobleman.
He was the son of Don Luis de la Cerda, 1st Duke of Medinaceli by third wife Catalina Bique de Orejón.
Since his parents only married "In Articulo Mortis" in 1501, he was considered a bastard for the first half of his life but was legitimated by the Catholic Monarchs as the eldest surviving male issue from the first Duke.
He took part in the battles for the incorporation of the Kingdom of Navarre into the unified Kingdom of Spain on behalf of King Ferdinand II of Aragon.
He also was a courtier under Queen Isabella I of Castile till 1504, of her daughter Queen Joanna of Castile "The Mad", and later supported her son King Charles I since 1516.
He was rewarded with a grandeeship in 1520.
Juan de la Cerda, 5th Duke of Medinaceli
Juan de la Cerda, 5th Duke of Medinaceli (1544 – 29 May 1594), Grandee of Spain, (in full), was a Spanish nobleman and Ambassador in Portugal.
He was the son of Don Juan de la Cerda, 4th Duke of Medinaceli and of Joana Manuel, daughter of Sancho de Noronha, 2nd Count of Faro.
In 1565 he married Donna Isabella d’Aragona, daughter of Don Antonio d’Aragona, 2nd Duke of Montalto with whom he had two children.
In 1580, he married for a second time, with Juana de la Lama, 4th Marchioness of la Adrada, a widow since 1571 of Don Gabriel de la Cueva, 5th Duke of Alburquerque, deceased as a Governor of the Duchy of Milan, Italy, with whom he had two more children.
Gastón de la Cerda, 3rd Duke of Medinaceli
Gastón de la Cerda, 3rd Duke of Medinaceli, Grandee of Spain,( in full),( c. 1507 – 1552) was a Spanish nobleman.
He was the second son of Don Juan de la Cerda, 2nd Duke of Medinaceli, by first wife Mencía Manuel de Portugal.
As a young man he became a monk in the Order of St. Jerome.
In 1536 after the death of his elder brother Luis without issue he became the heir to the family titles, so he sought a Papal dispensation in order to marry and fulfill his family obligations.
On 4 March 1540 he married María Sarmiento de la Cerda, a marriage that was eventually nulled on 30 August 1544, without issue.
Juan de la Cerda, 6th Duke of Medinaceli
Juan Luis de la Cerda, 6th Duke of Medinaceli, Grandee of Spain, (in full), (20 May 1569 – 24 November 1607) was a Spanish nobleman and Ambassador in Germanic countries.
He was born in Cogolludo, province of Guadalajara, the son of Don Juan de la Cerda, 5th Duke of Medinaceli, by first wife Donna Isabella d’Aragona, daughter of Don Antonio d’Aragona, 2nd Duke of Montalto.
In 1580 he married Ana de la Cueva, daughter of Don Gabriel de la Cueva, 5th Duke of Alburquerque with whom he had one daughter.
On 21 August 1606, he married for a second time, with Antonia de Toledo y Dávila, daughter of Don Gómez Dávila, 2nd Marquis of Velada and tutor of King Philip III of Spain, with whom he had one son.
He died shortly afterwards.
Juan de la Cerda, 4th Duke of Medinaceli
Juan de la Cerda, 4th Duke of Medinaceli( c. 1514 – 1575), Grandee of Spain, was a Spanish nobleman.
He was the son of Don Juan de la Cerda, 2nd Duke of Medinaceli, by second wife María de Silva.
In 1552 Juan de la Cerda inherited the titles from his older half- brother Gastón de la Cerda y Portugal.
Both half brothers, the 3rd, Gaston, and the 4th Duke, Juan II, are widely reported in many places and articles as being born" out of marriage" from different women and being" legitimated" males by the Crown as legal successors to their father, the second duke Juan I, also, apparently, a legitimated bastard, however.
In 1557, King Philip II of Spain appointed him Viceroy of Sicily, a position he held until 1564.
During that time he besieged with a fleet the North- African harbor of Tripoli, now in Libya, dealing with Dragut, a Turkish privateer and Ottoman admiral.
The force, including ships from Spain, Genoa, Tuscany, the Knights of Malta and the Papal States, was however nearly destroyed in the Battle of Djerba.
In 1567 he was appointed Viceroy of Navarre supposedly staying there till 1572, but it seems that towards the end of 1570, he became head of the household of Queen Anna of Austria, position he held until his death in 1575.
In the spring of 1572 Philip II sent Medinaceli to the Netherlands as governor.
According to Henry Kamen, Medinaceli reported to the king that" “ Excessive rigour, the misconduct of some officers and soldiers, and the Tenth Penny, are the cause of all the ills, and not heresy or rebellion. ”"
One of the governor ’s officers reported that in the Netherlands" “ the name of the house of Alba ”" was held in abhorrence.
Medinaceli lobbied the King for the removal of the Duke of Alba as military commander.
Deciding that the views of Medinaceli and Alba were not compatible, Philip II removed both and replaced them with Requesens.
Luis de la Cerda, 1st Marquis of Cogolludo
Luis de la Cerda, 1st Marquis of Cogolludo( in full)( c. 1506 – 1536) was a Spanish nobleman.
He was the eldest son of Don Juan de la Cerda, 2nd Duke of Medinaceli, by first wife Mencía Manuel de Portugal.
He married Ana de Mendoza, Lady of the Nueve Lugares de la Cuadrilla de Sierra- Alta del Ducado de Medinaceli, without issue.
Juan Tomas Enriquez de Cabrera, 7th Duke of Medina de Rioseco
Juan Tomás Enríquez de Cabrera y Ponce de Leon, VII Duque de Medina de Río- Seco( Genoa, Italy, 1646 – Estremoz, Portugal, 1705), was a Spanish noble and military.
He belonged to the important Enríquez family, whose title" Duque de Medina de Río- Seco" was awarded by King Charles I of Spain, Emperor Charles V, in April 1538.< br>
He was the 11th and last hereditary Admiral of Castile, Governor of the Duchy of Milan,( 1678 – 1686), Viceroy of Catalonia,( 1688), member of the State Council, ambassador in Rome and France, Caballerizo mayor to the King and Field Marshal of the Holy Roman Empire( 1705).
His grandfather, the 5th Duke of Medina de Rioseco, had been Juan Alfonso Enríquez de Cabrera, Viceroy of Sicily, in 1641 – 1644, and Viceroy of Naples in 1644 – 1646.
He was politically exiled from Spain by siding with Archduke Charles, later Emperor of the Holy Roman Empire Charles VI of Austria( 1685 – 1740) in the War of Spanish Succession.
He married in 1662 with Ana Catalina de la Cerda Portocarrero, daughter of Antonio de la Cerda, 7th Duke of Medinaceli.
After his wife's death, he remarried in 1697 with her niece, Ana Catalina de la Cerda y de Cardona- Aragon,( 1663 – 1698), widow since 1690 of Pedro Antonio de Aragón 5th Duke of Segorbe, Viceroy of Naples in 1664 – 1671, and daughter of Juan Francisco de la Cerda( 1637 – 1691), 8th Duke of Medinaceli, 6th Duke of Alcalá de los Gazules, Knight of the Order of the Golden Fleece in 1670, PM of King Carlos II of Spain and many other lesser titles, and Catalina Antonia de Cardona- Aragon y Sandoval, 9th Duchess of Cardona, 8th Duchess of Segorbe on her own rights.< br>
They had no surviving issue.
His wife Ana Catalina, was the sister of the 9th Duke of Medinaceli and main inheritor, Luis Francisco de la Cerda y de Cardona- Aragón,( 1654 – in prison, in the Castle of Pamplona in January 1711), who had married Maria de las Nieves Téllez Girón y Sandoval,+ 1732.
Luis Francisco de la Cerda, 9th Duke of Medinaceli
Luis Francisco de la Cerda y Aragón, 9th Duke of Medinaceli( 2 August 1660, in El Puerto de Santa María – 26 January 1711, in Pamplona), 9th Duke of Medinaceli, was a Spanish noble and politician.
Isabel de la Cerda
Isabel de la Cerda also known as" Isabel de la Cerda Pérez de Guzmán"( Seville c. 1329- after 1383) was the only surviving daughter of Luis de la Cerda and his first wife Leonor de Guzmán; she was Lady of Puerto de Santa María and titular Princess of Fortuna.
She was a member of the House de la Cerda.
Antonio de la Cerda, 7th Duke of Medinaceli
Antonio de la Cerda, 7th Duke of Medinaceli, Grandee of Spain,( in full),( 25 October 1607 – 7 March 1671) was a Spanish nobleman.
He was the son of Don Juan de la Cerda, 6th Duke of Medinaceli, by second wife Doña Antonia de Toledo y Dávila.
On 28 November 1625, in Dos Hermanas, province of Sevilla, at the age of 17 he married the 13- year- old Ana Portocarrero, 5th Duchess of Alcalá, with whom he had four children.
In 1641, he was appointed viceroy of Valencia, position he held for one year.
He died in Madrid.

Question: Who is Juan De La Cerda, 6Th Duke Of Medinaceli's paternal grandfather?
Answer: Juan de la Cerda, 4th Duke of Medinaceli