Margaret of Durazzo
Margaret of Durazzo (28 July 1347 – 6 August 1412) was Queen of Naples and Hungary and Princess of Achaea as the spouse of Charles III of Naples.
She was regent of Naples from 1386 until 1393 during the minority of her son Ladislaus of Naples.
Mary of Enghien
Mary of Enghien, also Maria d' Enghien,( 1367 or 1370 – 9 May 1446) was Countess of Lecce from 1384 to 1446, and Queen of Naples as well as titular Queen of Sicily, Jerusalem, and Hungary by marriage to Ladislaus of Naples in 1406- 1414.
Mary of Lusignan, Queen of Naples
Mary of Lusignan (1381 - 4 September 1404) was the second wife but first Queen consort of King Ladislaus of Naples.
She was born in Genoa.
Mary was a daughter of James I of Cyprus and his Queen consort Helvis of Brunswick-Grubenhagen.
On 12 February 1403, Mary married Ladislaus of Naples.
He had divorced his previous wife, Constance of Clermont, in 1392 while struggling for the throne against Louis II of Naples.
He had no legitimate heirs of his own.
Mary died childless in Naples the following year.
Ladislaus went on to marry Mary of Enghien.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Isabella of Lusignan
Isabella of Lusignan( c.1224 – 14 January 1300) was a daughter of Hugh X of Lusignan and his wife Isabella of Angoulême, Dowager Queen of England.
Isabella was half- sister to King Henry III of England.
She was Dame de Beauvoir- sur Mer et de Mercillac.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
James I of Cyprus
James I (1334 – September 9, 1398) was the youngest son of King Hugh IV of Cyprus and by 1369 held the title "Constable of Jerusalem.
" When his nephew Peter II died in 1382, James became King of Cyprus.
James was also titular King of Armenian Cilicia and Jerusalem 1382–1398.
James was the third son of Hugh IV of Cyprus and his second wife, Alix of Ibelin.
His older half-brother was Guy, Prince of Galilee (1320–43), and his two brothers were Peter I, King of Cyprus (1328-1369), and John of Lusignan, Prince of Antioch (1329-1375).
Before becoming king, James had other offices and was known for his resistance against the Genoese invasion of Cyprus.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Anne Denman
Anne Denman( 1587–1661) was born in Olde Hall, Retford, Nottinghamshire.
Through a fortunate second marriage with Thomas Aylesbury, she became the grandmother of Lady Anne Hyde, Duchess of York and great- grandmother of Queen Mary II and Queen Anne.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.

Question: Who is the paternal grandmother of Mary Of Lusignan, Queen Of Naples?
Answer: Alix of Ibelin