Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
John Lowther (died 1668)
Colonel Sir John Lowther (c. 1628 – March 1668) was an English landowner, at Hackthorpe, the eldest son and heir of Sir John Lowther, 1st Baronet and Mary Fletcher.
He first married, in 1665, Elizabeth Bellingham, daughter of Sir Henry Bellingham, 1st Baronet.
They had two children:
By his second marriage to Mary Withins, he had one (posthumous) son:
He predeceased his father and did not succeed to the baronetcy.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Anne Denman
Anne Denman( 1587–1661) was born in Olde Hall, Retford, Nottinghamshire.
Through a fortunate second marriage with Thomas Aylesbury, she became the grandmother of Lady Anne Hyde, Duchess of York and great- grandmother of Queen Mary II and Queen Anne.
Zac Lowther
Zacary William Lowther( born April 30, 1996) is an American professional baseball pitcher for the Baltimore Orioles organization.
William Lowther (1668–1694)
William Lowther (17 June 1668 – 28 July 1694) was an English Member of Parliament, the posthumous son of John Lowther and his second wife, Mary Withins.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Gülbahar Hatun (wife of Mehmed II)
Gülbahar Hatun( 1432 – 1492) was the consort of Sultan Mehmed II, and mother of Sultan Bayezid II of the Ottoman Empire and the grandmother of Selim I.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.
Mona Hopton Bell
Mona Hopton Bell( 1867- 1940) was a British artist, best known for her portraits of civic figures.
She was the grandmother of the painter Jean H. Bell.

Question: Who is the paternal grandmother of William Lowther (1668–1694)?
Answer: Mary Fletcher