Anne Denman
Anne Denman( 1587–1661) was born in Olde Hall, Retford, Nottinghamshire.
Through a fortunate second marriage with Thomas Aylesbury, she became the grandmother of Lady Anne Hyde, Duchess of York and great- grandmother of Queen Mary II and Queen Anne.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.
Purnima (Hindi actress)
Purnima Das Verma( born Meherbhano Mohammad Ali) was an Indian film actress who worked predominantly in Hindi language films.
She is the grandmother of actor Emraan Hashmi.
John Synadenos (megas konostaulos)
John Komnenos Doukas Palaiologos Synadenos  was a Byzantine noble and military leader in the early 14th century, holding the court title of "megas konostaulos".
He was the son (possibly the eldest) of the "megas stratopedarches" John Synadenos, and brother of the "protostrator" Theodore Synadenos.
He inherited the surname "Palaiologos" from his mother, Theodora Palaiologina Synadene, and was commonly referred to by it.
He married a lady named Thomais, descended form the imperial dynasties of Laskaris and Palaiologos, although her exact parentage is unknown.
No children of his are known.
Very little is known about his life, except that he acted as an emissary of Andronikos III Palaiologos to his grandfather Andronikos II during the closing stages of the Byzantine civil war of 1321–1328, along with John Aplesphares.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Mona Hopton Bell
Mona Hopton Bell( 1867- 1940) was a British artist, best known for her portraits of civic figures.
She was the grandmother of the painter Jean H. Bell.
Theodora Palaiologina Synadene
Theodora Palaiologina Synadene  was the daughter of Constantine Palaiologos and Irene Komnene Laskarina Branaina.
Through her father, she was a half-niece of the Byzantine Emperor Michael VIII Palaiologos.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Diana Guardato
Diana Guardato was a member of the aristocratic Patrician Guardato family, and had three children with King Ferdinand I: Diana Guardato is the 16th- Great Grandmother of His Royal Highness Albert II of Belgium, 15th- Great Grandmother of His Majesty Juan Carlos
I of Spain, 17th- Great Grandmother of Philippe of Belgium, 14th- Great Grandmother of His Majesty Manuel II of Portugal, 16th- Great Grandmother of Grand Duke Henri, as well as many others.

Question: Who is the maternal grandmother of John Synadenos (Megas Konostaulos)?
Answer: Irene Komnene Laskarina Branaina