George Palaiologos
George (Georgios) Palaiologos or Palaeologus  was a Byzantine general, one of the most prominent military commanders and supporters of Emperor Alexios I Komnenos (r. 1081–1118).
He was the son of the first known member of the Palaiologos family, the "strategos" of Mesopotamia Nikephoros Palaiologos.
His wife Anna Doukaina was the sister of Irene Doukaina, the wife of Alexios I Komnenos, making him the emperor's brother-in-law.
As Alexios Komnenos’ leading general and close friend, he played an important role in his campaigns, especially the Battle of Dyrrhachium against the Normans or the Battle of Levounion against the Pechenegs.
He was the chief source used by Anna Komnene in her "Alexiad" on her father’s battles, and is very favourably portrayed by her in her book as both capable and loyal.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Jiajak Jaqeli
Jiajak Jaqeli was the Empress consort of Alexios II of Trebizond.
Alexios Komnenos (co-emperor)
Alexios Komnenos, latinised as Alexius Comnenus , was the eldest son of the Byzantine emperor John II Komnenos and his wife Eirene of Hungary.
He was born in February 1106 at Balabista (today "Sidirokastro") in Macedonia, was made co-emperor with his father at 16 or 17 years of age and died on 2 August 1142 at Attalia, Pamphylia.
He was an elder brother of the emperor Manuel I Komnenos, and had a twin sister, Maria Komnene (plus other siblings).
Nicholas Kallikles
Nicholas Kallikles was a prominent physician and a leading court poet active in the Byzantine court in Constantinople during the reigns of Alexios I Komnenos( r. 1081– 1118) and John II Komnenos( r. 1118–1143).
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Anne Denman
Anne Denman( 1587–1661) was born in Olde Hall, Retford, Nottinghamshire.
Through a fortunate second marriage with Thomas Aylesbury, she became the grandmother of Lady Anne Hyde, Duchess of York and great- grandmother of Queen Mary II and Queen Anne.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.
John II Komnenos
John II Komnenos or Comnenus ("Iōannēs II Komnēnos"; 13 September 1087 – 8 April 1143) was Byzantine emperor from 1118 to 1143.
Also known as "John the Beautiful" or "John the GoodKaloïōannēs"), he was the eldest son of Emperor Alexios
I Komnenos and Irene Doukaina and the second emperor to rule during the Komnenian restoration of the Byzantine Empire.
John was a pious and dedicated monarch who was determined to undo the damage his empire had suffered following the battle of Manzikert, half a century earlier.
John has been assessed as the greatest of the Komnenian emperors.
In the course of his twenty-five year reign, John made alliances with the Holy Roman Empire in the west, decisively defeated the Pechenegs, Hungarians and Serbs in the Balkans, and personally led numerous campaigns against the Turks in Asia Minor.
John's campaigns fundamentally changed the balance of power in the east, forcing the Turks onto the defensive and restoring to the Byzantines many towns, fortresses and cities right across the Anatolian peninsula.
In the southeast, John extended Byzantine control from the Maeander in the west all the way to Cilicia and Tarsus in the east.
In an effort to demonstrate the Byzantine ideal of the emperor's role as the leader of the Christian world, John marched into Muslim Syria at the head of the combined forces of Byzantium and the Crusader states; yet despite the great vigour with which he pressed the campaign, John's hopes were disappointed by the evasiveness of his Crusader allies and their reluctance to fight alongside his forces.
Under John, the empire's population recovered to about 10 million people.
The quarter-century of John II's reign is less well recorded by contemporary or near-contemporary writers than the reigns of either his father, Alexios I, or his son, Manuel I.
In particular little is known of the history of John's domestic rule or policies.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.

Question: Who is the paternal grandmother of Alexios Komnenos (Co-Emperor)?
Answer: Irene Doukaina