Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Helena Kantakouzene, Empress of Trebizond
Helena Kantakouzene( died 1463) was the second wife of David of Trebizond, the last Emperor of Trebizond.
Recent research has led to doubts regarding her existence.
Irene of Trebizond
Irene of Trebizond( died around 1382) was the bigamous wife of Basil of Trebizond, by whom he had two sons, Alexios and John( later Alexios III of Trebizond), and possibly three daughters Anna, Maria and Theodora.
Maria of Gothia
Maria of Gothia was the first wife of David of Trebizond, last Emperor of Trebizond, whom she married in 1426.
John II of Trebizond
John II Megas Komnenos ("Iōannēs II Megas Komnēnos")
(c. 1262 – 16 August 1297) was Emperor of Trebizond from 1280 to 1297.
He was the youngest son of Emperor Manuel I and his third wife, Irene Syrikaina, a Trapezuntine noblewoman.
John succeeded to the throne after his full-brother George was betrayed by his archons on the mountain of Taurezion.
It was during his reign that the style of the rulers of Trebizond changed; until then, they claimed the traditional title of the Byzantine emperors, "Emperor and Autocrat of the Romans", but from John II on they changed it to "Emperor and Autocrat of all the East, the Iberians, and the Transmarine Provinces", although Iberia had been lost in the reign of Andronikos I Gidos.
John is the first ruler of Trebizond for whom we know more than a few incidents and hints; there is enough information to compose a connected narrative of the first part of his reign.
The chronicle of Michael Panaretos, which is often terse and even cryptic, is relatively full for John's reign, and external sources add further details to Panaretos' account.
Emperor John II faced many challenges to his rule, which partly explains his marriage to the daughter of the Byzantine emperor Michael VIII Palaiologos.
This insecurity may explain the sole instance where two Emperors of Trebizond appear on the coins of this polity: John and his oldest son, Alexios.
By associating himself with his son Alexios on these coins, John may be advertising his choice for his successor.
Rusudan of Georgia, Empress of Trebizond
Rusudan of Georgia, Empress of Trebizond was a consort of Manuel I of Trebizond, and the mother of Empress Theodora.
Very little is known for certain about her.
Michael of Trebizond
Michael Megas Komnenos (Greek:
Μιχαήλ Μέγας Κομνηνός, "Mikhaēl Megas Komnēnos"), (c. 1288– after 1355), Emperor of Trebizond for one day, July 30, 1341 and from May 3, 1344 to December 13, 1349.
He was a younger son of Emperor John II of Trebizond and Eudokia Palaiologina.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Mona Hopton Bell
Mona Hopton Bell( 1867- 1940) was a British artist, best known for her portraits of civic figures.
She was the grandmother of the painter Jean H. Bell.

Question: Who is the paternal grandmother of Michael Of Trebizond?
Answer: Irene Syrikaina