Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Infanta Catherine Michelle of Spain
Catherine Michelle of Spain (10 October 1567 – 6 November 1597) was a Duchess consort of Savoy who served as Regent of Savoy several times during the absence of her spouse, Charles Emmanuel
I, Duke of Savoy.
As the youngest surviving daughter of Philip II of Spain and Elisabeth of Valois, she was the sister of Isabella Clara Eugenia, Governor of the Habsburg Netherlands.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.
Philip II of Spain
Philip II of Spain (21 May 1527 – 13 September 1598) was King of Spain (1556–98), King of Portugal
(1581–98, as Philip I), King of Naples and Sicily (both from 1554), and "jure uxoris" King of England and Ireland (during his marriage to Queen Mary I from 1554 to 1558).
He was also Duke of Milan, and from 1555, lord of the Seventeen Provinces of the Netherlands.
The son of Holy Roman Emperor and King of the Spanish kingdoms Charles V and Isabella of Portugal, Philip was called "Felipe el PrudentePhilip the Prudent") in the Spanish kingdoms; his empire included territories on every continent then known to Europeans, including his namesake the Philippines.
During his reign, the Spanish kingdoms reached the height of its influence and power.
This is sometimes called the "Spanish Golden Age".
Philip led a highly debt-leveraged regime, seeing state bankruptcies in 1557, 1560, 1569, 1575, and 1596.
This policy was partly the cause of the declaration of independence that created the Dutch Republic in 1581.
On 31 December 1584 Philip signed the Treaty of Joinville, with Henry I, Duke of Guise signing on behalf of the Catholic League; consequently Philip supplied a considerable annual grant to the League over the following decade to maintain the civil war in France, with the hope of destroying the French Calvinists.
A devout Catholic, Philip saw himself as the defender of Catholic Europe against the Ottoman Empire and the Protestant Reformation.
He sent a large armada to invade Protestant England in 1588, with the strategic aim of overthrowing Elizabeth I of England and re-establishing Catholicism there.
He hoped to stop both English interference in the Spanish Netherlands and the harm caused to Spanish interests by English and Dutch privateering.
Philip was described by the Venetian ambassador Paolo Fagolo in 1563 as "slight of stature and round-faced, with pale blue eyes, somewhat prominent lip, and pink skin, but his overall appearance is very attractive".
The Ambassador went on to say "He dresses very tastefully, and everything that he does is courteous and gracious."
Besides Mary I, Philip was married three other times and widowed four times.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Alfonso III d'Este, Duke of Modena
Alfonso III d' Este( 22 October 1591 – 26 May 1644) was Duke of Modena and Reggio from 1628 to 1629.
He was the husband of Princess Isabella of Savoy, daughter of Charles Emmanuel I, Duke of Savoy and his wife Infanta Catherine Michelle of Spain.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Isabella of Savoy
Isabella of Savoy (11 March 1591 – 28 August 1626) was a daughter of Charles Emmanuel I, Duke of Savoy, and Catherine Michelle of Spain.
Her maternal grandparents were Philip II of Spain and Elisabeth of Valois, her paternal grandparents were Emmanuel Philibert, Duke of Savoy and Margaret of France, Duchess of Berry.
She was the Hereditary Princess of Modena, dying before her husband succeeded to the Duchy of Modena in 1628.
Diana Guardato
Diana Guardato was a member of the aristocratic Patrician Guardato family, and had three children with King Ferdinand I: Diana Guardato is the 16th- Great Grandmother of His Royal Highness Albert II of Belgium, 15th- Great Grandmother of His Majesty Juan Carlos
I of Spain, 17th- Great Grandmother of Philippe of Belgium, 14th- Great Grandmother of His Majesty Manuel II of Portugal, 16th- Great Grandmother of Grand Duke Henri, as well as many others.
Anne Denman
Anne Denman( 1587–1661) was born in Olde Hall, Retford, Nottinghamshire.
Through a fortunate second marriage with Thomas Aylesbury, she became the grandmother of Lady Anne Hyde, Duchess of York and great- grandmother of Queen Mary II and Queen Anne.

Question: Who is Infanta Catherine Michelle Of Spain's paternal grandmother?
Answer: Isabella of Portugal