Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Konstancja Lubomirska
Princess Konstancja Lubomirska( ca. 1618–1646) was a Polish noble lady.
Konstancja married Kazimierz Franciszek Czarnkowski on 1 February 1637 in Kraków.
She was the mother of Adam Uriel Czarnkowski, grandmother of Zofia Anna Czarnkowska, Great- grandmother of Katarzyna Opalinska and the great- great- grandmother of Maria Leszczyńska.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.
Mona Hopton Bell
Mona Hopton Bell( 1867- 1940) was a British artist, best known for her portraits of civic figures.
She was the grandmother of the painter Jean H. Bell.
Manuel, Prince of Portugal (1531–1537)
Manuel, Prince of Portugal( 11 November 1531 – 14 April 1537), was the Prince of Portugal from 1535 to his death in 1537.
He was the fifth child son of king John III of Portugal and Catherine of Austria.
In 1535, his father officially designated him as Prince of Portugal, taking the place of his eldest sister Infanta Maria Manuela.
However, after his premature death at five years old, his younger brother Infante Filipe became the next Prince of Portugal.
Maria Manuela, Princess of Portugal
Dona Maria Manuela (15 October 1527 – 12 July 1545) was the eldest daughter and second child of King John III of Portugal and his wife Catherine of Austria.
She was Princess of Asturias and Duchess of Milan as the first wife of the future Philip II of Spain, and Princess of Portugal as heir presumptive to the Portuguese throne between 1527 and 1535.
Diana Guardato
Diana Guardato was a member of the aristocratic Patrician Guardato family, and had three children with King Ferdinand I: Diana Guardato is the 16th- Great Grandmother of His Royal Highness Albert II of Belgium, 15th- Great Grandmother of His Majesty Juan Carlos
I of Spain, 17th- Great Grandmother of Philippe of Belgium, 14th- Great Grandmother of His Majesty Manuel II of Portugal, 16th- Great Grandmother of Grand Duke Henri, as well as many others.
John III of Portugal
John III (7 June 1502 – 11 June 1557) nicknamed The Colonizer (Portuguese: "o Colonizador")
was the King of Portugal and the Algarves from 13 December 1521 to 11 June 1557.
He was the son of King Manuel I and Maria of Aragon, the third daughter of King Ferdinand II of Aragon and Queen Isabella
I of Castile.
John succeeded his father in 1521, at the age of nineteen.
During his rule, Portuguese possessions were extended in Asia and in the New World through the Portuguese colonization of Brazil.
John III's policy of reinforcing Portugal's bases in India (such as Goa) secured Portugal's monopoly over the spice trade of cloves and nutmeg from the Maluku Islands, as a result of which John III has been called the "Grocer King".
On the eve of his death in 1557, the Portuguese empire had a global dimension and spanned almost 1 billion acres (about 4 million square kilometers).
During his reign, the Portuguese became the first Europeans to make contact with both China, under the Ming dynasty, and Japan, during the Muromachi period.
He abandoned Muslim territories in North Africa in favor of trade with India and investment in Brazil.
In Europe, he improved relations with the Baltic region and the Rhineland, hoping that this would bolster Portuguese trade.

Question: Who is the paternal grandmother of Maria Manuela, Princess Of Portugal?
Answer: Maria of Aragon