Pedro Téllez-Girón, 1st Duke of Osuna
Pedro Téllez-Girón, 1st Duke of Osuna, 5th count of Ureña (29 July 1537 – 13 September 1590) was a Spanish nobleman and administrator.
Born at Osuna, he was the eldest son of Juan Téllez-Girón, 4th Count of Ureña and of María de la Cueva y Toledo, daughter of Francisco Fernández de la Cueva, 2nd Duke of Alburquerque.
He succeeded to his father's titles in 1558 and on 5 February 1562, King Philip II of Spain awarded him the title of Duke of Osuna, together with the subsidiary title of Marquis of Peñafiel for his eldest male descendants.
In 1582, he was appointed Viceroy of Naples, a position he held until 1586.
He was also Ambassador in Portugal and to the Holy See with Pope Sixtus V.
He was lord of Osuna, Peñafiel, Cazalla de la Sierra, el Arahal, Olvera, Archidona, Morón de la Frontera, Ortejícar, Briones, Tiedra, Gumiel de Izán and others.
In 1552, aged 15, the future duke married Leonor Ana de Guzmán y Aragón
(c.1540 – 23 November 1573), daughter of Juan Alfonso Pérez de Guzmán, 6th Duke of Medina Sidonia.
Her name has been associated since then to the actual "Reserve of the BioSphere" known as the Coto de Doñana.
Together they had eleven children.
On 2 February 1575, he married again, this time his cousin, Isabel de la Cueva y Castilla, with whom he had another two children.
Among his children from the first marriage, he had:
It is reported that being already a Duke he had an illegitimate son, known as the theatrical author Tirso de Molina.
Alfonso Téllez-Girón, 1st Count of Ureña
Alfonso Téllez- Girón, 1st Count of Ureña,( in full),( c.1454–1469), was a Spanish nobleman.
Alfonso Téllez- Girón was born in Moral de Calatrava, the eldest natural son of Pedro Girón, 1st Lord of Osuna and of Inés de las Casas.
He was legitimated by Papal bull on 22 April 1456, confirmed by King Henry IV of Castile on 30 April 1459.
The same king granted him the title of Count of Ureña( originally Urueña) on 25 May 1464.
He married Blanca de Herrera, Lady of Pedraza de la Sierra, but had no issue.
Alfonso Téllez- Girón died in El Espinar, Segovia, due to complications of a broken foot suffered during a ball game.
Juan Téllez-Girón, 2nd Duke of Osuna
Juan Téllez- Girón, 2nd Duke of Osuna, Grandee of Spain,( in full),( 20 Octubre 1559 – 25 November 1600), was a Spanish nobleman.
Juan Téllez- Girón was the son of Pedro Girón, 1st Duke of Osuna and of Leonor Ana de Guzmán y Aragón( c.1540–23 November 1573), daughter of Juan Alfonso Pérez de Guzmán, 3rd Duke of Medina Sidonia.
In 1570, he married his cousin Ana María de Velasco, daughter of Íñigo Fernández de Velasco, 4th Duke of Frías, with whom he had 5 children.
Pedro Téllez-Girón, 8th Duke of Osuna
Pedro Zoilo Téllez- Girón y Pérez de Guzmán, 8th Duke de Osuna, Grandee of Spain,( in full),( 27 June 1728 – 1 April 1787), was a Spanish nobleman.
Pedro Téllez- Girón was the son of José María Téllez- Girón, 7th Duke of Osuna and of Francisca Pérez de Guzmán y Mendoza, daughter of Manuel Pérez de Guzmán, 12th Duke of Medina Sidonia.
He married his niece María Vicenta Pacheco Téllez- Girón in 1753.
Juan Téllez-Girón, 4th Count of Ureña
Juan Téllez-Girón, "the saint", 4th Count of Ureña (in full) (25 April 1494 – 19 May 1558) was a Spanish nobleman.
Juan Téllez-Girón was born in Osuna, the third son of Juan Téllez-Girón, 2nd Count of Ureña and of Leonor de la Vega Velasco, daughter of Pedro Fernández de Velasco, 2nd Count of Haro.
He succeeded to the titles of his older brother in 1531.
He married María de la Cueva y Toledo, daughter of Francisco Fernández de la Cueva, 2nd Duke of Alburquerque
and they had 6 children.
In 1549, he founded a College and University in Osuna.
He was nicknamed "the saint" because he also created a Franciscan and a Dominican monasteries in his Osuna domains.
Juan Téllez-Girón, 2nd Count of Ureña
Juan Téllez- Girón, 2nd Count of Ureña( in full)( c. 1456 – 21 May 1528) was a Spanish nobleman.
Juan Téllez- Girón was the third natural son of Pedro Girón, 1st Lord of Osuna and of Inés de las Casas.
The children were legitimated by Papal bull on March 1466, confirmed by King Henry IV of Castile.
He succeeded to the titles of his older brother in 1469.
He married Leonor de la Vega Velasco, daughter of Pedro Fernández de Velasco, 2nd Count of Haro, with whom he had 15 children.
Francisco Téllez-Girón, 10th Duke de Osuna
Francisco de Borja Téllez- Girón y Pimentel, 10th Duke de Osuna, Grandee of Spain( in full),( 6 October 1785 – 21 May 1820), was a Spanish nobleman.
Francisco Téllez- Girón was the 7th son of Pedro Téllez- Girón, 9th Duke of Osuna( 1756 – 1807) and was the 10th Duke of Osuna since 1807.
He married in 1802, Countess Marie Françoise Philippine Beaufort- Spontin( 1785 – 1830), daughter of Frederic Augustus Alexander, Duke of Beaufort- Spontin and his wife Leopoldina Álvarez de Toledo( 1760 – 1792), who in turn was the daughter of Pedro de Alcántara Álvarez de Toledo y Silva, 12th Duke of the Infantado.
Their son the 11th Duke, Pedro de Álcantara was born in 1810, but died in 1844 without issue.
Ana de Velasco y Girón
Ana de Velasco y Téllez-Girón (1585 – Vila Viçosa November 7, 1607) was a Spanish noblewoman and mother of John IV of Portugal, the first Portuguese King of the Braganza Dynasty.
She was the daughter of Juan Fernández de Velasco, 5th Duke of Frías and Maria Tellez-Giron, daughter of Andalusian Duke of Osuna, Pedro Téllez-Girón, 1st Duke of Osuna
Juan Tellez-Girón y Enriquez de Ribera, 4th Duke of Osuna
Juan Tellez-Girón y Enriquez de Ribera, 4th Duke of Osuna (15 November 1597 – 12 October 1656) was Viceroy of Sicily from 1655 to 1656.
He was the only male descendant of Pedro Téllez-Girón, 3rd Duke of Osuna who was born in December 1579, and was Viceroy of Sicily from 1610 to 1615 and Viceroy of Naples from 1615 to 1620.
His mother was Catalina Enriquez de Ribera y Cortés who died in November 1635 and was one of 3 daughters of Fernando Enriquez, 2nd Duke of Alcalá de los Gazules.
He married Isabel Raimunda de Sandoval y Padilla, who died in 1658 and was the daughter of Cristóbal de Sandoval, Duke of Uceda.
They had two children:
Joaquina Téllez-Girón, Marquise of Santa Cruz
Doña Joaquina Téllez- Girón y Pimentel, Marquise of Santa Cruz, Grandee of Spain," suo jure" 2nd Countess of Osilo( Spanish:" Doña Joaquina Téllez- Girón, marquesa de Santa Cruz"; 21 September 1784 – 17 November 1851) was a daughter of Pedro Téllez- Girón, 9th Duke of Osuna and María Josefa Pimentel, 12th Countess- Duchess of Benavente.
In 1801, she married José Gabriel de Silva- Bazán y Waldstein, the future Marquis of Santa Cruz.
She is best known as the subject of an 1805 portrait by Francisco José de Goya y Lucientes, a family friend.

Question: Who is the paternal grandfather of Pedro Téllez-Girón, 1St Duke Of Osuna?
Answer: Juan Téllez-Girón, 2nd Count of Ureña