João Manuel (footballer, born 1967)
João Manuel Loureiro dos Santos, known as João Manuel( born 31 August 1967; died 18 May 2005 of multiple sclerosis) was a Portuguese football player.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Edward, King of Portugal
Duarte (31 October 1391 – 9 September 1438), known in English as Edward and called the Philosopher ("o Rei-Filósofo") or the Eloquent ("o Eloquente"), was King of Portugal from 1433 until his death.
He was born in Viseu, the son of John I of Portugal and his wife, Philippa of Lancaster.
Edward was the oldest member of the "Illustrious Generation" of accomplished royal children who contributed to the development of Portuguese civilization during the 15th century.
As a cousin of several English kings, he became a Knight of the Garter.
Mona Hopton Bell
Mona Hopton Bell( 1867- 1940) was a British artist, best known for her portraits of civic figures.
She was the grandmother of the painter Jean H. Bell.
José João Manuel
José João Manuel is the ambassador of Angola to Israel.
João Manuel Pinto
João Manuel Pinto Tomé Santos( born 26 May 1973), known as João Pinto or João Manuel Pinto, is a retired Portuguese professional footballer who played as a central defender, and is a manager.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
João Manuel (bishop of Guarda)
João Manuel (Lisbon, c. 1416 – December 1476) was a religious Carmelite, Bishop of Ceuta (1443-1459) and Bishop of Guarda (1459-1476).
Although some genealogists claimed that he was the son of Edward, King of Portugal and Joana Manuel de Vilhena, great-granddaughter of Juan Manuel, Prince of Villena,
Anselmo Braamcamp Freire dismisses such filiation and provides sufficient arguments against it.
João Manuel joined the Carmelites in 1441 to become provincial of the Order in Portugal.
He was made titular Bishop of Tiberias at the same time by Pope Eugene IV.
He was also the ambassador to Hungary.
In 1443, he was appointed Bishop of Ceuta and primate of Africa.
In 1450, he became chaplain to King Afonso V of Portugal.
Finally, in 1459, he was appointed Bishop of Guarda, a town in which he never actually lived.
From a relationship he had with a Justa Rodrigues, he had two sons, who served Alfonso V and John II of Portugal during their reigns: João Manuel (1466-1500), mayor of Santarém, and Nuno Manuel (1469- after 1500), Lord of Salvaterra de Magos.
He is buried at the Carmo Church  located at the Carmo Convent , a medieval convent later ruined in the 1755 Lisbon earthquake.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.

Question: Who is João Manuel (Bishop Of Guarda)'s paternal grandmother?
Answer: Philippa of Lancaster