Manuel, Prince of Portugal (1531–1537)
Manuel, Prince of Portugal( 11 November 1531 – 14 April 1537), was the Prince of Portugal from 1535 to his death in 1537.
He was the fifth child son of king John III of Portugal and Catherine of Austria.
In 1535, his father officially designated him as Prince of Portugal, taking the place of his eldest sister Infanta Maria Manuela.
However, after his premature death at five years old, his younger brother Infante Filipe became the next Prince of Portugal.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
John III of Portugal
John III (7 June 1502 – 11 June 1557) nicknamed The Colonizer (Portuguese: "o Colonizador")
was the King of Portugal and the Algarves from 13 December 1521 to 11 June 1557.
He was the son of King Manuel I and Maria of Aragon, the third daughter of King Ferdinand II of Aragon and Queen Isabella
I of Castile.
John succeeded his father in 1521, at the age of nineteen.
During his rule, Portuguese possessions were extended in Asia and in the New World through the Portuguese colonization of Brazil.
John III's policy of reinforcing Portugal's bases in India (such as Goa) secured Portugal's monopoly over the spice trade of cloves and nutmeg from the Maluku Islands, as a result of which John III has been called the "Grocer King".
On the eve of his death in 1557, the Portuguese empire had a global dimension and spanned almost 1 billion acres (about 4 million square kilometers).
During his reign, the Portuguese became the first Europeans to make contact with both China, under the Ming dynasty, and Japan, during the Muromachi period.
He abandoned Muslim territories in North Africa in favor of trade with India and investment in Brazil.
In Europe, he improved relations with the Baltic region and the Rhineland, hoping that this would bolster Portuguese trade.
João Manuel (footballer, born 1967)
João Manuel Loureiro dos Santos, known as João Manuel( born 31 August 1967; died 18 May 2005 of multiple sclerosis) was a Portuguese football player.
João Manuel (bishop of Guarda)
João Manuel( Lisbon, c. 1416 – December 1476) was a religious Carmelite, Bishop of Ceuta( 1443- 1459) and Bishop of Guarda( 1459- 1476).
Although some genealogists claimed that he was the son of Edward, King of Portugal and Joana Manuel de Vilhena, great- granddaughter of Juan Manuel, Prince of Villena, Anselmo Braamcamp Freire dismisses such filiation and provides sufficient arguments against it.
João Manuel joined the Carmelites in 1441 to become provincial of the Order in Portugal.
He was made titular Bishop of Tiberias at the same time by Pope Eugene IV.
He was also the ambassador to Hungary.
In 1443, he was appointed Bishop of Ceuta and primate of Africa.
In 1450, he became chaplain to King Afonso V of Portugal.
Finally, in 1459, he was appointed Bishop of Guarda, a town in which he never actually lived.
From a relationship he had with a Justa Rodrigues, he had two sons, who served Alfonso V and John II of Portugal during their reigns: João Manuel( 1466- 1500), mayor of Santarém, and Nuno Manuel( 1469- after 1500), Lord of Salvaterra de Magos.
He is buried at the Carmo Church located at the Carmo Convent, a medieval convent later ruined in the 1755 Lisbon earthquake.
João Manuel, Prince of Portugal
João Manuel, Prince of Portugal  (3 June 1537 – 2 January 1554) was a Portuguese "infante" (prince), the eighth son of King John III of Portugal by his wife Catherine of Austria, daughter of Philip I of Castile and Joanna of Castile.
As the heir to the throne he was styled Prince of Portugal.
José João Manuel
José João Manuel is the ambassador of Angola to Israel.
Afonso, Prince of Portugal (1526)
Afonso, Prince of Portugal was the first son of king John III of Portugal and his queen, Catherine of Austria.
He was the Prince of Portugal but died in the same year he was born, in 1526.
Sebastian of Portugal
Sebastian( 20 January
1554 – 4 August 1578) was King of Portugal from 11 June 1557 to 4 August 1578 and the penultimate Portuguese monarch of the House of Aviz.
He was the son of João Manuel, Prince of Portugal, and his wife, Joanna of Austria.
He was the grandson of King John III of Portugal and Holy Roman Emperor Charles V.
He disappeared( presumably killed in action) in the battle of Alcácer Quibir.
Sebastian I is often referred to as" The Desired"( Portuguese:" o Desejado") or" The Asleep"( Portuguese:" o Adormecido"), as the Portuguese people longed for his return to end the decline of Portugal that began after his death.
He is considered to be the Portuguese example of the king in the mountain legend as Portuguese tradition states his return, in a foggy dawn, on Portugal's greatest hour of need.
Philip, Prince of Portugal
Filipe, Prince of Portugal( 25 March 1533 – 29 April 1539), was the Prince of Portugal from 1537 to his death in 1539.
He was the sixth child son of king John III of Portugal and Catherine of Austria.
In 1537, he succeeded his brother Prince Manuel as Prince of Portugal, after his premature death.
However, after his own premature death, two years later, after reaching six years old, his younger brother Infante João Manuel became the next Prince of Portugal.

Question: Who is the paternal grandmother of João Manuel, Prince Of Portugal?
Answer: Maria of Aragon