Irene of Trebizond
Irene of Trebizond( died around 1382) was the bigamous wife of Basil of Trebizond, by whom he had two sons, Alexios and John( later Alexios III of Trebizond), and possibly three daughters Anna, Maria and Theodora.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Irene Palaiologina (Byzantine empress)
Irene Palaiologina( died after 1356), was the Empress consort of Matthew Kantakouzenos.
Helena Megale Komnene
Helena Megale Komnene  (died 1366) is the name given for the first wife of King Bagrat V of Georgia.
Her first name is recorded in "The Georgian Chronicle", and her family name is based on a theory which identifies her as a daughter of Basil of Trebizond.
If true, the identity of her mother would be uncertain.
Basil was bigamous, concurrently married to Irene Palaiologina and Irene of Trebizond.
Helena died in 1366, victim to a plague which had spread across Georgia during the 1350s and 1360s (possibly a recurrence of the Black Death).
A year after her death, her husband married Anna of Trebizond.
According to the "Georgian Chronicle", Helena was survived by two children:
Irene Palaiologina of Trebizond
Irene Palaiologina (Greek:
Ειρήνη Παλαιολογίνα, "Eirēnē Palaiologina"), (c. 1315 – after 1341) was Empress of Trebizond from April 6, 1340 to July 17, 1341.
She was an illegitimate daughter of the Byzantine Emperor Andronikos III Palaiologos, and she married Emperor Basil of Trebizond in 1335.
Rusudan of Georgia, Empress of Trebizond
Rusudan of Georgia, Empress of Trebizond was a consort of Manuel I of Trebizond, and the mother of Empress Theodora.
Very little is known for certain about her.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Andronikos III Palaiologos
Andronikos III Palaiologos (25 March 1297 – 15 June 1341), commonly Latinized as Andronicus III Palaeologus, was the Byzantine emperor from 1328 to 1341.
Born Andronikos Doukas Angelos Komnenos Palaiologos , he was the son of Michael IX Palaiologos and Rita of Armenia.
He was proclaimed co-emperor in his youth, before 1313, and in April 1321 he rebelled in opposition to his grandfather, Andronikos II Palaiologos.
He was formally crowned co-emperor in February 1325, before ousting his grandfather outright and becoming sole emperor on 24 May 1328.
His reign included the last failed attempts to hold back the Ottoman Turks in Bithynia and the defeat at Rusokastro against the Bulgarians, but also the successful recovery of Chios, Lesbos, Phocaea, Thessaly, and Epirus.
His early death left a power vacuum that resulted in the disastrous civil war between his Empress-dowager, Anna of Savoy, and his closest friend and supporter, John VI Kantakouzenos.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Maria of Gothia
Maria of Gothia was the first wife of David of Trebizond, last Emperor of Trebizond, whom she married in 1426.

Question: Who is the paternal grandmother of Irene Palaiologina Of Trebizond?
Answer: Rita of Armenia