Diana Guardato
Diana Guardato was a member of the aristocratic Patrician Guardato family, and had three children with King Ferdinand I: Diana Guardato is the 16th- Great Grandmother of His Royal Highness Albert II of Belgium, 15th- Great Grandmother of His Majesty Juan Carlos
I of Spain, 17th- Great Grandmother of Philippe of Belgium, 14th- Great Grandmother of His Majesty Manuel II of Portugal, 16th- Great Grandmother of Grand Duke Henri, as well as many others.
Tjuyu
Tjuyu( sometimes transliterated as Thuya or Thuyu) was an Egyptian noblewoman and the mother of queen Tiye, and the wife of Yuya.
She is the grandmother of Akhenaten, and great grandmother of Tutankhamun.
Purnima (Hindi actress)
Purnima Das Verma( born Meherbhano Mohammad Ali) was an Indian film actress who worked predominantly in Hindi language films.
She is the grandmother of actor Emraan Hashmi.
Anne Denman
Anne Denman( 1587–1661) was born in Olde Hall, Retford, Nottinghamshire.
Through a fortunate second marriage with Thomas Aylesbury, she became the grandmother of Lady Anne Hyde, Duchess of York and great- grandmother of Queen Mary II and Queen Anne.
Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Mona Hopton Bell
Mona Hopton Bell( 1867- 1940) was a British artist, best known for her portraits of civic figures.
She was the grandmother of the painter Jean H. Bell.
Gian Giacomo Crispo
Gian Giacomo Crispo (1446–1453) was the fourteenth Duke of the Archipelago, etc., from 1447 to 1453, son of the thirteenth Duke Giacomo II Crispo and Ginevra Gattilusio.
Kaoru Hatoyama
After the elections of 2009, she became more widely known as the grandmother of Prime Minister Yukio Hatoyama and his politician brother Kunio Hatoyama.
Hannah Arnold
Hannah Arnold, also known as Hannah Waterman King, was the grandmother of Benedict Arnolds children.
Giacomo II Crispo
Giacomo II Crispo (or Jacopo) (1426–1447) was the thirteenth Duke of the Archipelago, etc., from 1433 to 1447.
He was the son of twelfth Duke John II Crispo and "Nobil Donna" Francesca Morosini, Patrizia Veneta.
He was a minor when he succeeded to the throne, and during his minority, the Duchy was ruled by his mother Francesca, described as a "masterful woman", who continued to influence in the affairs of state during the reign of her son and grandson until the accession of William II to the throne in 1453.
The reign of Giacomo II was reportedly a peaceful and prosperous one, as the Ottomans were occupied in Hungary, and Venice included the Duchy in their protection in their peace treaty with the Ottomans in 1446.
He married in 1444 Ginevra Gattilusio, daughter of Dorino
I of Lesbos, and wife Orietta Doria, and had two children:

Question: Who is the paternal grandmother of Gian Giacomo Crispo?
Answer: Francesca Morosini