Tlacaelel
Tlacaelel I (1397 – 1487) was the principal architect of the Aztec Triple Alliance and hence the Mexica (Aztec) empire.
He was the son of Emperor Huitzilihuitl and Queen Cacamacihuatl, nephew of Emperor Itzcoatl, father of poet Macuilxochitzin, and brother of Emperors Chimalpopoca and Moctezuma I.
During the reign of his uncle Itzcoatl, Tlacaelel was given the office of Tlacochcalcatl, but during the war against the Tepanecs in the late 1420s, he was promoted to first adviser to the ruler, a position called "Cihuacoatl" in Nahuatl, an office that Tlacaelel held during the reigns of four consecutive "Tlatoque", until his death in 1487.
Tlacaelel recast or strengthened the concept of the Aztecs as a chosen people, elevated the tribal god/hero Huitzilopochtli to top of the pantheon of gods, and increased militarism.
In tandem with this, Tlacaelel is said to have increased the level and prevalence of human sacrifice, particularly during a period of natural disasters that started in 1446 (according to Diego Durán).
Durán also states that it was during the reign of Moctezuma I, as an invention of Tlacaelel that the flower wars, in which the Aztecs fought Tlaxcala and other Nahuan city-states, were instigated.
To strengthen the Aztec nobility, he helped create and enforce sumptuary laws, prohibiting commoners from wearing certain adornments such as lip plugs, gold armbands, and cotton cloaks.
He also instigated a policy of burning the books of conquered peoples with the aim of erasing all memories of a pre-Aztec past.
When he dedicated the seventh reconstruction of the Templo Mayor in Tenochtitlan, Tlacaelel had brought his nation to the height of its power.
The dedication took place in 1484 and was celebrated with the sacrifice of many war captives.
After Tlacaelel's death in 1487, the Mexica Empire continued to expand north into the Gran Chichimeca and south toward the Maya lands.
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Maquiztzin
Maquiztzin was the daughter of the Aztec Tlatoque (ruler)
Huehue Quetzalmacatzin and Tlacocihuatzin Ilama, in 15th-century Mesoamerica.
She married Tenochcan Tlacaelel and moved to Tenochtitlan with him.
She had five children.
Her eldest son was Cacamatzin.
One of other children was the great warrior Tlilpotoncatzin.
The last child was Princess Xiuhpopocatzin.
It is unknown where she went.
She was a grandmother of Tlacaelel II, and an ancestor of Leonor Moctezuma and María Moctezuma.

Question: Who is Maquiztzin's sibling-in-law?
Answer: Chimalpopoca