user: From this passage, extract the treatments for ACO in a bulleted list.

assistant: <think>
Treatment of ACO is based on expert opinion as there are no universally accepted clinical guidelines. Treatment is usually based on whether clinical features of asthma or COPD predominate. Inhaled corticosteroids are the primary treatment in those with ACOS. Inhaled corticosteroids (ICS) should be continued in those with asthma who develop decreased airway responsiveness to bronchodilators consistent with ACO. Therapy can be escalated to include a long acting beta-agonist (LABA) and inhaled steroid combination (ICS-LABA) or by adding on a long-acting anti-muscarinic inhaler (LAMA), known as triple therapy, in those with more severe or resistant disease.

Monoclonal antibodies targeting type 2 inflammation (which is predominant in asthma) have been used to treat severe asthma, and may also be used in severe cases of ACO. These monoclonal antibodies include omalizumab (an Anti-IgE antibody), mepolizumab (an anti-IL-5 antibody) and benralizumab (an anti-IL-5 receptor α antibody). People with ACOS and eosinophilia have a better response to ICS; with fewer exacerbations and hospitalizations seen in ACOS treated with long term ICS. Systemic corticosteroids (intravenous or oral steroids) may be used during exacerbations of ACOS.
https://en.wikipedia.org/wiki/Asthma-COPD_overlap</think>
-Inhaled corticosteroids
-long acting beta-agonist (LABA) and inhaled steroid combination (ICS-LABA)
-triple therapy (in other words, adding on a long-acting anti-muscarinic inhaler (LAMA)
-monoclonal antibodies targeting type 2 inflammation
-systemic corticosteroids (intravenous or oral steroids)

user: What is the name of the world's oldest city?

assistant: The city of Jericho, located near the Jordan River in Palestine, is the earliest known city and played an important role in the development of the Neolithic Revolution. Since 9000 BC, nomadic settlers have been drawn here by the warm temperatures, natural springs, and the land's suitability for cultivation.

user: Who was the first player sent off during a soccer match?

assistant: <think>
This is a list of all occasions where a football player was sent off from a FIFA World Cup match due to a foul or misconduct, either as a direct expulsion (red card) or as a second caution (yellow card) within the match.

This list includes all dismissals since the first World Cup in 1930. The use of physical red and yellow cards to respectively indicate dismissals and cautions is a later invention, having been introduced at the 1970 tournament.

Only players are listed, even if they were at the substitutes' bench at the time of the sending off. Managers and other technical staff members are not covered.

Statistics
Plácido Galindo was the first player to be sent off in a World Cup match, playing for Peru against Romania in a 1930 match officiated by Alberto Warnken. Although physical red cards were introduced from 1970, they were not put in practice until the 1974 World Cup, when referee Doğan Babacan sent off Chile's Carlos Caszely during a match against West Germany.
Two players have received red cards twice: Cameroon's Rigobert Song (1994 and 1998) and France's Zinedine Zidane (1998 and 2006).
Five dismissals have taken place during final matches: Argentina's Pedro Monzón and Gustavo Dezotti (both 1990), France's Marcel Desailly (1998) and Zinedine Zidane (2006), and John Heitinga of the Netherlands (2010).
Uruguay's José Batista received the quickest red card, in the first minute in a game against Scotland in 1986.
A few expulsions either took place after the final whistle of the match or were awarded to players at the substitutes' bench (or both), and thus did not reduce the number of players on the pitch during the game. Two of them, that of Leandro Cufré of Argentina (vs Germany, 2006) and that of Denzel Dumfries of the Netherlands (vs Argentina, 2022), took place after the penalty shoot-outs of knockout matches, making them the latest red cards.
Three goalkeepers have been sent off in the tournament: Italy's Gianluca Pagliuca (1994), South Africa's Itumeleng Khune (2010), and Wales's Wayne Hennessey (2022).
The match with the most dismissals was Portugal vs Netherlands of 2006, when referee Valentin Ivanov dished out 4 red cards, 2 for each team.
The referee who has sent off the most players is Arturo Brizio Carter, 7 red cards, in 5 different matches (also a record).
The team that has the greatest number of expulsed players is Brazil, with 11 – in 9 different matches, a record shared with Argentina. The team whose opponents have received the most red cards is Germany (incl. West Germany), with 20 – in 18 different matches, also a record.
The 2006 World Cup had the highest amount of red cards: a total of 28 players were sent off (in 20 matches, also a record).</think>
Plácido Galindo was the first player to be sent off in a World Cup match, playing for Peru against Romania in a 1930 match officiated by Alberto Warnken. Although physical red cards were introduced from 1970, they were not put in practice until the 1974 World Cup, when referee Doğan Babacan sent off Chile's Carlos Caszely during a match against West Germany.