user: Given a reference text about multiple myeloma, tell me the risk factors and the cause of the disease.

assistant: <think>
Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. Often, no symptoms are noticed initially. As it progresses, bone pain, anemia, kidney dysfunction, and infections may occur. Complications may include amyloidosis.

The cause of multiple myeloma is unknown. Risk factors include obesity, radiation exposure, family history, and certain chemicals. There is an increased risk of multiple myeloma in certain occupations. This is due to the occupational exposure to aromatic hydrocarbon solvents having a role in causation of multiple myeloma. Multiple myeloma may develop from monoclonal gammopathy of undetermined significance that progresses to smoldering myeloma. The abnormal plasma cells produce abnormal antibodies, which can cause kidney problems and overly thick blood. The plasma cells can also form a mass in the bone marrow or soft tissue. When one tumor is present, it is called a plasmacytoma; more than one is called multiple myeloma. Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibodies, bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. Another common finding is high blood calcium levels.</think>
Although the cause of multiple myeloma is not known, risk factors for developing the disease are obesity, radiation exposure, family history, and exposure to certain chemicals.

user: Can you describe Gene expression?

assistant: Genes generally express their functional effect through the production of proteins, molecules responsible for most functions in the cell. Proteins are made up of one or more polypeptide chains, each composed of a sequence of amino acids. The DNA sequence of a gene is used to produce a specific amino acid sequence. This process begins with the production of an RNA molecule with a sequence matching the gene's DNA sequence, a process called transcription.

This messenger RNA molecule then serves to produce a corresponding amino acid sequence through a process called translation. Each group of three nucleotides in the sequence, called a codon, corresponds either to one of the twenty possible amino acids in a protein or an instruction to end the amino acid sequence; this correspondence is called the genetic code. The flow of information is unidirectional: information is transferred from nucleotide sequences into the amino acid sequence of proteins, but it never transfers from protein back into the sequence of DNA—a phenomenon Francis Crick called the central dogma of molecular biology.

The specific sequence of amino acids results in a unique three-dimensional structure for that protein, and the three-dimensional structures of proteins are related to their functions. Some are simple structural molecules, like the fibers formed by the protein collagen. Proteins can bind to other proteins and simple molecules, sometimes acting as enzymes by facilitating chemical reactions within the bound molecules (without changing the structure of the protein itself). Protein structure is dynamic; the protein hemoglobin bends into slightly different forms as it facilitates the capture, transport, and release of oxygen molecules within mammalian blood.

user: please tell me about the golden gate bridge without quoting directly from this text

assistant: <think>
The Golden Gate Bridge is a suspension bridge spanning the Golden Gate, the one-mile-wide (1.6 km) strait connecting San Francisco Bay and the Pacific Ocean. The structure links the U.S. city of San Francisco, California—the northern tip of the San Francisco Peninsula—to Marin County, carrying both U.S. Route 101 and California State Route 1 across the strait. It also carries pedestrian and bicycle traffic, and is designated as part of U.S. Bicycle Route 95. Recognized by the American Society of Civil Engineers as one of the Wonders of the Modern World, the bridge is one of the most internationally recognized symbols of San Francisco and California.</think>
The Golden Gate Bridge is a suspension bridge spanning the Golden Gate, the one-mile-wide (1.6 km) strait connecting San Francisco Bay and the Pacific Ocean. The structure links the U.S. city of San Francisco, California—the northern tip of the San Francisco Peninsula—to Marin County, carrying both U.S. Route 101 and California State Route 1 across the strait. It also carries pedestrian and bicycle traffic, and is designated as part of U.S. Bicycle Route 95. Recognized by the American Society of Civil Engineers as one of the Wonders of the Modern World, the bridge is one of the most internationally recognized symbols of San Francisco and California.

The idea of a fixed link between San Francisco and Marin had gained increasing popularity during the late 19th century, but it was not until the early 20th century that such a link became feasible. Joseph Strauss served as chief engineer for the project, with Leon Moisseiff, Irving Morrow and Charles Ellis making significant contributions to its design. The bridge opened to the public in 1937 and has undergone various retrofits and other improvement projects in the decades since.

The Golden Gate Bridge is described in Frommer's travel guide as "possibly the most beautiful, certainly the most photographed, bridge in the world."At the time of its opening in 1937, it was both the longest and the tallest suspension bridge in the world, titles it held until 1964 and 1998 respectively. Its main span is 4,200 feet (1,280 m) and total height is 746 feet (227 m)