The discovery of these enzymes began with studies of ıTetrahymena thermophila and its intron-catalyzed splicing system.
The discovery of these enzymes began with studies of ıTetrahymena thermophila and its intron-catalyzed splicing system. Among their varieties are the hammerhead and hairpin types and most of them can be en-gineered to cleave RNA ıin trans. Their secondary structure can be deduced from the primary sequence by analyzing the base pairing and free energy reduction during the folding. They were discovered by Thomas Cech of the University of Colorado, Boulder, who showed that RNA is autocatalytic, which led to speculation that life began with RNA as both genetic material and catalyst. Also including viroids and ribosomes, FTP, name this type of enzyme made of only RNA.
The discovery of these enzymes began with studies of ıTetrahymena thermophila and its intron-catalyzed splicing system.
ribozyme