It can begin with lactate in hepatocytes, yielding NADH needed for conversion of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphate, and making export of NADH from mitochondria unnecessary, as pyruvate is carboxylated to oxaloacetate, which is then decarboxylated to PEP.
It can begin with lactate in hepatocytes, yielding NADH needed for conversion of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphate, and making export of NADH from mitochondria unnecessary, as pyruvate is carboxylated to oxaloacetate, which is then decarboxylated to PEP. In this process, fructose 1,6-bisphosphatase and glucose 6-phosphate are hydrolyzed, because no ATP need be formed. In animals, it occurs in liver and kidneys, while in plants, an additional step turns the product to sucrose. For 10 points, name this pathway, the reverse of glycolysis, converting pyruvate to glucose.
It can begin with lactate in hepatocytes, yielding NADH needed for conversion of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphate, and making export of NADH from mitochondria unnecessary, as pyruvate is carboxylated to oxaloacetate, which is then decarboxylated to PEP.
{gluconeogenesis}