Quinolone and coumarin are two antibacterial substances that work by inhibiting one class of these enzymes.
Quinolone and coumarin are two antibacterial substances that work by inhibiting one class of these enzymes. Adriamycin, ellipticine, and the alkaloid camptothecin (*) also inhibit the activity of these enzymes, and are thus used as possible anticancer drugs. Their type II class operates by having the substrate molecule bind to tyrosine residues on the active site, forming a "G segment" and a "T segment," and, ultimately, changing the linking number of the substrate. Often used for decatenation and cleavage for assays, all of them are able to relax negative supercoils, effectively opposing the action of DNA gyrase. FTP, name these enzymes which are responsible for sorting out the topological tangles of the DNA double helix.
Quinolone and coumarin are two antibacterial substances that work by inhibiting one class of these enzymes.
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