An alternative to SILAC called BONCAT uses substrates compatible with this reaction.
An alternative to SILAC called BONCAT uses substrates compatible with this reaction. THPTA stabilizes this reaction's catalyst, which is normally generated in situ by reduction with sodium ascorbate.  Highly strained eight-membered rings like OCT or BARAC are common substrates for this reaction. Carolyn Bertozzi developed non-canonical amino acids used in this reaction for labelling biomolecules. Its catalyst was discovered by Kolb 38 years after this reaction was named. MG Finn, Valery Fokin, and (*) Barry Sharpless will probably win a Nobel for this reaction, which is carried out at room temperature in water with a copper catalyst. Its product is a five-membered ring with three consecutive nitrogen atoms. For 10 points, name this 1,3-dipolar cycloaddition, a classic click reaction, in which a triazole is synthesized from an alkyne and an azide.
An alternative to SILAC called BONCAT uses substrates compatible with this reaction.
Huisgen cycloaddition [or alkyne-azide cycloaddition until "alkyne" is read; or CuAAC; or 1,3 dipolar cycloaddition until it is read; prompt on cycloaddition] 