A commercially important mechanism for this procedure uses 10-deacetylbaccatin III, an intermediate in the natural form of this process.
A commercially important mechanism for this procedure uses 10-deacetylbaccatin III, an intermediate in the natural form of this process.The most recent of these procedures to be published uses the monoterpene geraniol. Nearly all mechanisms for this procedure involve the addition of a tail via the Ojima lactam. A convergent method of this procedure begins with the Wieland-Miescher Ketone as the C ring and then adds on the D and (*) AB rings separately. That method was discovered by Danishefsky. Differences in the publishing time between Nature and JACS led to controversy over whether Nicolau or Holton was the first to perform this procedure whose end product was once illegally controlled solely by Bristol-Myers Squibb. For 10 points, name this procedure where a medically useful product of the Pacific Yew tree is produced from more readily available reagents.
A commercially important mechanism for this procedure uses 10-deacetylbaccatin III, an intermediate in the natural form of this process.
Taxol Total Synthesis [Also Accept Paclitaxel Total Synthesis; prompt on equivalents like Making Taxol]