In side forms of this signaling pathway, a complex with Daam1 is formed, which eventually leads to the activation of ROCK.
In side forms of this signaling pathway, a complex with Daam1 is formed, which eventually leads to the activation of ROCK. The receptors for one form of this signaling pathway bind to LRP and may also bind to other factors such as axin. The main signaling molecule in this pathway is found in high concentrations in Spemann's Organizer. The main effect of this pathway is to affect DNA-binding transcription factors called LEF/TCF. Those receptors for this pathway are GPCRs that form part of the frizzled family. Downstream of the receptor, GSK3 is turned off, which leads to the buildup of beta-catenin, which eventually migrates into the nucleus. For 10 points, name this signaling pathway whose name derives from the wingless gene of the fruit fly and which modulates neural induction, differentiation, and neural crest differentiation.
In side forms of this signaling pathway, a complex with Daam1 is formed, which eventually leads to the activation of ROCK.
Wnt signaling pathway