The book that codified this technique, which was coauthored by Xue-Min Cheng, divides it into five strategies, including topological and transform-based.
The book that codified this technique, which was coauthored by Xue-Min Cheng, divides it into five strategies, including topological and transform-based. The CHIRON and LHASA software packages implement this technique by constructing an EXTGT tree. Practitioners of this technique try to identify ancillary keying elements. This process relies on labelling groups as either A-class, E-class, or G-class donors, then determining whether there is a consonant or dissonant pattern when latent (*) polarities alternate between positive and negative. Umpolung can be achieved in this technique using a formyl-acyl transformation. Double arrows are used in this technique to represent transforms between synthons and synthetic equivalents. For 10 points, name this technique formalized by EJ Corey, which plans an organic synthesis by starting from the target and working backwards.
The book that codified this technique, which was coauthored by Xue-Min Cheng, divides it into five strategies, including topological and transform-based.
retrosynthesis [or retrosynthetic analysis; or antithetic analysis; prompt on organic synthesis] 