This process is promoted by a paracrine loop in which the production of EGF by macrophages is increased by CSF-1.
This process is promoted by a paracrine loop in which the production of EGF by macrophages is increased by CSF-1. Stephen Paget's "seed and soil" hypothesis explains that cross-talk is vital for this process' success. Preceding it, over-expression of Snail, Slug, and Twist causes repression of E-cadherin, and an invadopodium degrades the basement membrane. This process requires an epithelial-mesenchymal transition. Intravasation allows cells undergoing this process to (*) cross into the lymphatic system and the bloodstream. Classically, malignant tumors, but not benign tumors, do this. For 10 points, name this process responsible for more than 90% of all deaths from cancer, in which tumor cells spread from a primary tumor to other sites.
This process is promoted by a paracrine loop in which the production of EGF by macrophages is increased by CSF-1.
metastasis [or word forms]