The LUMA assay uses chemiluminescent methods to detect this process, and bisulfite treatment or pyrosequencing can also be used to detect it.
The LUMA assay uses chemiluminescent methods to detect this process, and bisulfite treatment or pyrosequencing can also be used to detect it. It can be inhibited by decitabine, and errors in one protein responsible for it cause the rare ICF syndrome. It is also important in distinguishing the template strand during MutL-MutS-mediated mismatch repair. It occurs in CpG islands within promoter sequences as a means of regulation, and it is a common vehicle for genomic imprinting, as seen in Prader-Willi and Angelman's syndromes. Also occurring excessively in the CGG repeats of Fragile-X syndrome and in Barr bodies, FTP, name this mechanism of gene silencing involving the attachment of the namesake chemical group to DNA.
The LUMA assay uses chemiluminescent methods to detect this process, and bisulfite treatment or pyrosequencing can also be used to detect it.
DNA {Methylation} (Don’t accept protein or histone methylation; all of the clues are unique to DNA methylation)