A group of proteins including Cernunnos, Artemis, and XRCC4 is responsible for cleaning up after this process as part of a DNA-PK complex; that complex is responsible for an error-prone version of the NHEJ process.
A group of proteins including Cernunnos, Artemis, and XRCC4 is responsible for cleaning up after this process as part of a DNA-PK complex; that complex is responsible for an error-prone version of the NHEJ process. The main protein involved in this process contains a DDE motif in the active site and a nonamer-binding region, and is mutated in Omenn syndrome. This process obeys the 12/23 or one-turn/two-turn rule for spacers, and occurs around RSS sites. A polyadenylation signal exists right after the C-mu site in the target locus of this process, and this process occurs between the alpha and beta chains of the T-cell receptor. This process is complementary to somatic hypermutation and was originally outlined by Tonegawa. For 10 points, name this process when diversity, variable, and joining chains of certain loci are cut up and moved during B-cell development, leading to the creation of diverse antibodies.
A group of proteins including Cernunnos, Artemis, and XRCC4 is responsible for cleaning up after this process as part of a DNA-PK complex; that complex is responsible for an error-prone version of the NHEJ process.
{VDJ recombination} or {VJ recombination} (accept {NHEJ }or {non- homologous end-joining} until mention, accept "{Immunoglobulin creation}" or "{Immunoglobulin synthesis}" or "{Antibody synthesis}" or whatever until mention, prompt on "{recombination}" or "{homologous recombination}")