In vertebrates, one protein critical to this process has a KEN box instead of a D box, which is recognized by a CDH1 complex.
In vertebrates, one protein critical to this process has a KEN box instead of a D box, which is recognized by a CDH1 complex. That protein, CDC20, complexes with a promoting cyclosome to start this process by degrading S and M cyclins and cleaving a protein dephosphorylated by CDC14, securin. Separase is then released, which removes cohesin from chromosomes. In this phase, polar microtubules are lengthened and kinetochore microtubules contract, which drags sister chromatids to opposite poles of the cell. For 10 points, name this stage of mitosis that follows metaphase and precedes telophase. 
In vertebrates, one protein critical to this process has a KEN box instead of a D box, which is recognized by a CDH1 complex.
anaphase [accept anaphase II before "mitosis"; accept anaphase I before "chromatids"; prompt on mitosis or meiosis before "start this process"] 