They can be directly coupled to alkyl, vinyl, or aryl halides by using a nickel catalyst in the Kumada reaction, and when added to triethyl orthoformate, they form aldehydes in the Bodroux-Chichibabin synthesis.
They can be directly coupled to alkyl, vinyl, or aryl halides by using a nickel catalyst in the Kumada reaction, and when added to triethyl orthoformate, they form aldehydes in the Bodroux-Chichibabin synthesis. Solutions of them spontaneously dimerize via the Schlenk equilibrium, which is why it is necessary for them to be coordinated to aprotic solvents like diethyl ether or THF. More common reactions of them are addition to a nitrile to form an imine, and the formation of tertiary alcohols by adding them to an ester. However, they most famously add to carbonyl compounds to create alcohols, and since they are strong bases, adding water creates the corresponding alkane. FTP, what are these magnesium halide organometallic reagents, named for their French discoverer?
They can be directly coupled to alkyl, vinyl, or aryl halides by using a nickel catalyst in the Kumada reaction, and when added to triethyl orthoformate, they form aldehydes in the Bodroux-Chichibabin synthesis.
{Grignard} reagents