The suspected route of transmission is through consumption of infected beef products (although recently human-to-human transmission of vCJD through blood transfusion has been described).
Arvatav nakkuse edasikandumistee on nakatunud loomalihatoodete tarbimine (kuigi viimasel ajal on kirjeldatud ka vCJD kandumist inimeselt inimesele vereülekande kaudu).