sentence1: Recently, it was reported that expression of IDH1R132H suppresses TET2 activity and the mutations of IDH1 and IDH2 genes occur in a mutual exclusive manner with that of TET2 gene in AML.
sentence2: This large-scale study showed that IDH1/IDH2 mutations were mutually exclusive with inactivating TET2 mutations, suggesting that the two types of mutations had similar effects and were thus functionally redundant.