sentence1: Consequently miRNAs have been demonstrated to act either as oncogenes (e.g., miR-155, miR-17−5p and miR-21) or tumor suppressors (e.g., miR-34, miR-15a, miR-16−1 and let-7)
sentence2: Given the extensive involvement of miRNA in physiology, dysregulation of miRNA expression can be associated with cancer pathobiology including oncogenesis], proliferation, epithelial-mesenchymal transition, metastasis, aberrations in metabolism, and angiogenesis, among others