pwc-archive/papers-with-abstracts huggingface dataset:
Diffusion Generative Modeling for Spatially Resolved Gene Expression Inference from Histology Images
Authors: Sichen Zhu, Yuchen Zhu, Molei Tao, Peng Qiu
Date: 2025-01-26 00:00:00

Spatial Transcriptomics (ST) allows a high-resolution measurement of RNA sequence abundance by systematically connecting cell morphology depicted in Hematoxylin and Eosin (H&E) stained histology images to spatially resolved gene expressions. ST is a time-consuming, expensive yet powerful experimental technique that provides new opportunities to understand cancer mechanisms at a fine-grained molecular level, which is critical for uncovering new approaches for disease diagnosis and treatments. Here, we present $\textbf{Stem}$ ($\textbf{S}$pa$\textbf{T}$ially resolved gene $\textbf{E}$xpression inference with diffusion $\textbf{M}$odel), a novel computational tool that leverages a conditional diffusion generative model to enable in silico gene expression inference from H&E stained images. Through better capturing the inherent stochasticity and heterogeneity in ST data, $\textbf{Stem}$ achieves state-of-the-art performance on spatial gene expression prediction and generates biologically meaningful gene profiles for new H&E stained images at test time. We evaluate the proposed algorithm on datasets with various tissue sources and sequencing platforms, where it demonstrates clear improvement over existing approaches. $\textbf{Stem}$ generates high-fidelity gene expression predictions that share similar gene variation levels as ground truth data, suggesting that our method preserves the underlying biological heterogeneity. Our proposed pipeline opens up the possibility of analyzing existing, easily accessible H&E stained histology images from a genomics point of view without physically performing gene expression profiling and empowers potential biological discovery from H&E stained histology images.
SCP-116K: A High-Quality Problem-Solution Dataset and a Generalized Pipeline for Automated Extraction in the Higher Education Science Domain
Authors: Dakuan Lu, Xiaoyu Tan, Rui Xu, Tianchu Yao, Chao Qu, Wei Chu, Yinghui Xu, Yuan Qi
Date: 2025-01-26 00:00:00

Recent breakthroughs in large language models (LLMs) exemplified by the impressive mathematical and scientific reasoning capabilities of the o1 model have spotlighted the critical importance of high-quality training data in advancing LLM performance across STEM disciplines. While the mathematics community has benefited from a growing body of curated datasets, the scientific domain at the higher education level has long suffered from a scarcity of comparable resources. To address this gap, we present SCP-116K, a new large-scale dataset of 116,756 high-quality problem-solution pairs, automatically extracted from heterogeneous sources using a streamlined and highly generalizable pipeline. Our approach involves stringent filtering to ensure the scientific rigor and educational level of the extracted materials, while maintaining adaptability for future expansions or domain transfers. By openly releasing both the dataset and the extraction pipeline, we seek to foster research on scientific reasoning, enable comprehensive performance evaluations of new LLMs, and lower the barrier to replicating the successes of advanced models like o1 in the broader science community. We believe SCP-116K will serve as a critical resource, catalyzing progress in high-level scientific reasoning tasks and promoting further innovations in LLM development. The dataset and code are publicly available at https://github.com/AQA6666/SCP-116K-open.
Twin Transition or Competing Interests? Validation of the Artificial Intelligence and Sustainability Perceptions Inventory (AISPI)
Authors: Annika Bush
Date: 2025-01-26 00:00:00

As artificial intelligence (AI) and sustainability initiatives increasingly intersect, understanding public perceptions of their relationship becomes crucial for successful implementation. However, no validated instrument exists to measure these specific perceptions. This paper presents the development and validation of the Artificial Intelligence and Sustainability Perceptions Inventory (AISPI), a novel 13-item instrument measuring how individuals view the relationship between AI advancement and environmental sustainability. Through factor analysis (N=105), we identified two distinct dimensions: Twin Transition and Competing Interests. The instrument demonstrated strong reliability (alpha=.89) and construct validity through correlations with established measures of AI and sustainability attitudes. Our findings suggest that individuals can simultaneously recognize both synergies and tensions in the AI-sustainability relationship, offering important implications for researchers and practitioners working at this critical intersection. This work provides a foundational tool for future research on public perceptions of AI's role in sustainable development.
Comparative clinical evaluation of "memory-efficient" synthetic 3d generative adversarial networks (gan) head-to-head to state of art: results on computed tomography of the chest
Authors: Mahshid shiri, Chandra Bortolotto, Alessandro Bruno, Alessio Consonni, Daniela Maria Grasso, Leonardo Brizzi, Daniele Loiacono, Lorenzo Preda
Date: 2025-01-26 00:00:00
Tasks: Image Generation

Generative Adversarial Networks (GANs) are increasingly used to generate synthetic medical images, addressing the critical shortage of annotated data for training Artificial Intelligence systems. This study introduces CRF-GAN, a novel memory-efficient GAN architecture that enhances structural consistency in 3D medical image synthesis. Integrating Conditional Random Fields within a two-step generation process allows CRF-GAN improving spatial coherence while maintaining high-resolution image quality. The model's performance is evaluated against the state-of-the-art hierarchical (HA)-GAN model. Materials and Methods: We evaluate the performance of CRF-GAN against the HA-GAN model. The comparison between the two models was made through a quantitative evaluation, using FID and MMD metrics, and a qualitative evaluation, through a two-alternative forced choice (2AFC) test completed by a pool of 12 resident radiologists, to assess the realism of the generated images. Results: CRF-GAN outperformed HA-GAN with lower FID and MMD scores, indicating better image fidelity. The 2AFC test showed a significant preference for images generated by CRF-Gan over those generated by HA-GAN. Additionally, CRF-GAN demonstrated 9.34% lower memory usage and achieved up to 14.6% faster training speeds, offering substantial computational savings. Discussion: CRF-GAN model successfully generates high-resolution 3D medical images with non-inferior quality to conventional models, while being more memory-efficient and faster. The key objective was not only to lower the computational cost but also to reallocate the freed-up resources towards the creation of higher-resolution 3D imaging, which is still a critical factor limiting their direct clinical applicability. Moreover, unlike many previous studies, we combined qualitative and quantitative assessments to obtain a more holistic feedback on the model's performance.
Diffusion-Based Planning for Autonomous Driving with Flexible Guidance
Authors: Yinan Zheng, Ruiming Liang, Kexin Zheng, Jinliang Zheng, Liyuan Mao, Jianxiong Li, Weihao Gu, Rui Ai, Shengbo Eben Li, Xianyuan Zhan, Jingjing Liu
Date: 2025-01-26 00:00:00
Tasks: Autonomous Driving, Imitation Learning

Achieving human-like driving behaviors in complex open-world environments is a critical challenge in autonomous driving. Contemporary learning-based planning approaches such as imitation learning methods often struggle to balance competing objectives and lack of safety assurance,due to limited adaptability and inadequacy in learning complex multi-modal behaviors commonly exhibited in human planning, not to mention their strong reliance on the fallback strategy with predefined rules. We propose a novel transformer-based Diffusion Planner for closed-loop planning, which can effectively model multi-modal driving behavior and ensure trajectory quality without any rule-based refinement. Our model supports joint modeling of both prediction and planning tasks under the same architecture, enabling cooperative behaviors between vehicles. Moreover, by learning the gradient of the trajectory score function and employing a flexible classifier guidance mechanism, Diffusion Planner effectively achieves safe and adaptable planning behaviors. Evaluations on the large-scale real-world autonomous planning benchmark nuPlan and our newly collected 200-hour delivery-vehicle driving dataset demonstrate that Diffusion Planner achieves state-of-the-art closed-loop performance with robust transferability in diverse driving styles.
CE-SDWV: Effective and Efficient Concept Erasure for Text-to-Image Diffusion Models via a Semantic-Driven Word Vocabulary
Authors: Jiahang Tu, Qian Feng, Chufan Chen, Jiahua Dong, Hanbin Zhao, Chao Zhang, Hui Qian
Date: 2025-01-26 00:00:00

Large-scale text-to-image (T2I) diffusion models have achieved remarkable generative performance about various concepts. With the limitation of privacy and safety in practice, the generative capability concerning NSFW (Not Safe For Work) concepts is undesirable, e.g., producing sexually explicit photos, and licensed images. The concept erasure task for T2I diffusion models has attracted considerable attention and requires an effective and efficient method. To achieve this goal, we propose a CE-SDWV framework, which removes the target concepts (e.g., NSFW concepts) of T2I diffusion models in the text semantic space by only adjusting the text condition tokens and does not need to re-train the original T2I diffusion model's weights. Specifically, our framework first builds a target concept-related word vocabulary to enhance the representation of the target concepts within the text semantic space, and then utilizes an adaptive semantic component suppression strategy to ablate the target concept-related semantic information in the text condition tokens. To further adapt the above text condition tokens to the original image semantic space, we propose an end-to-end gradient-orthogonal token optimization strategy. Extensive experiments on I2P and UnlearnCanvas benchmarks demonstrate the effectiveness and efficiency of our method.
Distributionally Robust Graph Out-of-Distribution Recommendation via Diffusion Model
Authors: Chu Zhao, Enneng Yang, Yuliang Liang, Jianzhe Zhao, Guibing Guo, Xingwei Wang
Date: 2025-01-26 00:00:00
Tasks: Graph Neural Network, Recommendation Systems

The distributionally robust optimization (DRO)-based graph neural network methods improve recommendation systems' out-of-distribution (OOD) generalization by optimizing the model's worst-case performance. However, these studies fail to consider the impact of noisy samples in the training data, which results in diminished generalization capabilities and lower accuracy. Through experimental and theoretical analysis, this paper reveals that current DRO-based graph recommendation methods assign greater weight to noise distribution, leading to model parameter learning being dominated by it. When the model overly focuses on fitting noise samples in the training data, it may learn irrelevant or meaningless features that cannot be generalized to OOD data. To address this challenge, we design a Distributionally Robust Graph model for OOD recommendation (DRGO). Specifically, our method first employs a simple and effective diffusion paradigm to alleviate the noisy effect in the latent space. Additionally, an entropy regularization term is introduced in the DRO objective function to avoid extreme sample weights in the worst-case distribution. Finally, we provide a theoretical proof of the generalization error bound of DRGO as well as a theoretical analysis of how our approach mitigates noisy sample effects, which helps to better understand the proposed framework from a theoretical perspective. We conduct extensive experiments on four datasets to evaluate the effectiveness of our framework against three typical distribution shifts, and the results demonstrate its superiority in both independently and identically distributed distributions (IID) and OOD.
Building Efficient Lightweight CNN Models
Authors: Nathan Isong
Date: 2025-01-26 00:00:00
Tasks: image-classification, Image Classification, Transfer Learning

Convolutional Neural Networks (CNNs) are pivotal in image classification tasks due to their robust feature extraction capabilities. However, their high computational and memory requirements pose challenges for deployment in resource-constrained environments. This paper introduces a methodology to construct lightweight CNNs while maintaining competitive accuracy. The approach integrates two stages of training; dual-input-output model and transfer learning with progressive unfreezing. The dual-input-output model train on original and augmented datasets, enhancing robustness. Progressive unfreezing is applied to the unified model to optimize pre-learned features during fine-tuning, enabling faster convergence and improved model accuracy. The methodology was evaluated on three benchmark datasets; handwritten digit MNIST, fashion MNIST, and CIFAR-10. The proposed model achieved a state-of-the-art accuracy of 99% on the handwritten digit MNIST and 89% on fashion MNIST, with only 14,862 parameters and a model size of 0.17 MB. While performance on CIFAR-10 was comparatively lower (65% with less than 20,00 parameters), the results highlight the scalability of this method. The final model demonstrated fast inference times and low latency, making it suitable for real-time applications. Future directions include exploring advanced augmentation techniques, improving architectural scalability for complex datasets, and extending the methodology to tasks beyond classification. This research underscores the potential for creating efficient, scalable, and task-specific CNNs for diverse applications.
Advancing Generative Artificial Intelligence and Large Language Models for Demand Side Management with Internet of Electric Vehicles
Authors: Hanwen Zhang, Ruichen Zhang, Wei zhang, Dusit Niyato, Yonggang Wen
Date: 2025-01-26 00:00:00
Tasks: Code Generation, energy management, Management, Retrieval, Retrieval-augmented Generation, Scheduling

Generative artificial intelligence, particularly through large language models (LLMs), is poised to transform energy optimization and demand side management (DSM) within microgrids. This paper explores the integration of LLMs into energy management, emphasizing their roles in automating the optimization of DSM strategies with Internet of electric vehicles. We investigate challenges and solutions associated with DSM and explore the new opportunities presented by leveraging LLMs. Then, we propose an innovative solution that enhances LLMs with retrieval-augmented generation for automatic problem formulation, code generation, and customizing optimization. We present a case study to demonstrate the effectiveness of our proposed solution in charging scheduling and optimization for electric vehicles, highlighting our solution's significant advancements in energy efficiency and user adaptability. This work underscores the potential of LLMs for energy optimization and fosters a new era of intelligent DSM solutions.
UNIDOOR: A Universal Framework for Action-Level Backdoor Attacks in Deep Reinforcement Learning
Authors: Oubo Ma, Linkang Du, Yang Dai, Chunyi Zhou, Qingming Li, Yuwen Pu, Shouling Ji
Date: 2025-01-26 00:00:00
Tasks: Backdoor Attack, Deep Reinforcement Learning

Deep reinforcement learning (DRL) is widely applied to safety-critical decision-making scenarios. However, DRL is vulnerable to backdoor attacks, especially action-level backdoors, which pose significant threats through precise manipulation and flexible activation, risking outcomes like vehicle collisions or drone crashes. The key distinction of action-level backdoors lies in the utilization of the backdoor reward function to associate triggers with target actions. Nevertheless, existing studies typically rely on backdoor reward functions with fixed values or conditional flipping, which lack universality across diverse DRL tasks and backdoor designs, resulting in fluctuations or even failure in practice. This paper proposes the first universal action-level backdoor attack framework, called UNIDOOR, which enables adaptive exploration of backdoor reward functions through performance monitoring, eliminating the reliance on expert knowledge and grid search. We highlight that action tampering serves as a crucial component of action-level backdoor attacks in continuous action scenarios, as it addresses attack failures caused by low-frequency target actions. Extensive evaluations demonstrate that UNIDOOR significantly enhances the attack performance of action-level backdoors, showcasing its universality across diverse attack scenarios, including single/multiple agents, single/multiple backdoors, discrete/continuous action spaces, and sparse/dense reward signals. Furthermore, visualization results encompassing state distribution, neuron activation, and animations demonstrate the stealthiness of UNIDOOR. The source code of UNIDOOR can be found at https://github.com/maoubo/UNIDOOR.
FIT-Print: Towards False-claim-resistant Model Ownership Verification via Targeted Fingerprint
Authors: Shuo Shao, Haozhe Zhu, Hongwei Yao, Yiming Li, Tianwei Zhang, Zhan Qin, Kui Ren
Date: 2025-01-26 00:00:00

Model fingerprinting is a widely adopted approach to safeguard the copyright of open-source models by detecting and preventing their unauthorized reuse without modifying the protected model. However, in this paper, we reveal that existing fingerprinting methods are vulnerable to false claim attacks where adversaries falsely assert ownership of third-party non-reused models. We find that this vulnerability mostly stems from their untargeted nature, where they generally compare the outputs of given samples on different models instead of the similarities to specific references. Motivated by this finding, we propose a targeted fingerprinting paradigm (i.e., FIT-Print) to counteract false claim attacks. Specifically, FIT-Print transforms the fingerprint into a targeted signature via optimization. Building on the principles of FIT-Print, we develop bit-wise and list-wise black-box model fingerprinting methods, i.e., FIT-ModelDiff and FIT-LIME, which exploit the distance between model outputs and the feature attribution of specific samples as the fingerprint, respectively. Experiments on benchmark models and datasets verify the effectiveness, conferrability, and resistance to false claim attacks of our FIT-Print.
Expert-Free Online Transfer Learning in Multi-Agent Reinforcement Learning
Authors: Alberto Castagna
Date: 2025-01-26 00:00:00
Tasks: Multi-agent Reinforcement Learning, reinforcement-learning, Reinforcement Learning, Reinforcement Learning (RL), Transfer Learning

Reinforcement Learning (RL) enables an intelligent agent to optimise its performance in a task by continuously taking action from an observed state and receiving a feedback from the environment in form of rewards. RL typically uses tables or linear approximators to map state-action tuples that maximises the reward. Combining RL with deep neural networks (DRL) significantly increases its scalability and enables it to address more complex problems than before. However, DRL also inherits downsides from both RL and deep learning. Despite DRL improves generalisation across similar state-action pairs when compared to simpler RL policy representations like tabular methods, it still requires the agent to adequately explore the state-action space. Additionally, deep methods require more training data, with the volume of data escalating with the complexity and size of the neural network. As a result, deep RL requires a long time to collect enough agent-environment samples and to successfully learn the underlying policy. Furthermore, often even a slight alteration to the task invalidates any previous acquired knowledge. To address these shortcomings, Transfer Learning (TL) has been introduced, which enables the use of external knowledge from other tasks or agents to enhance a learning process. The goal of TL is to reduce the learning complexity for an agent dealing with an unfamiliar task by simplifying the exploration process. This is achieved by lowering the amount of new information required by its learning model, resulting in a reduced overall convergence time...
Color Flow Imaging Microscopy Improves Identification of Stress Sources of Protein Aggregates in Biopharmaceuticals
Authors: Michaela Cohrs, Shiwoo Koak, Yejin Lee, Yu Jin Sung, Wesley De Neve, Hristo L. Svilenov, Utku Ozbulak
Date: 2025-01-26 00:00:00

Protein-based therapeutics play a pivotal role in modern medicine targeting various diseases. Despite their therapeutic importance, these products can aggregate and form subvisible particles (SvPs), which can compromise their efficacy and trigger immunological responses, emphasizing the critical need for robust monitoring techniques. Flow Imaging Microscopy (FIM) has been a significant advancement in detecting SvPs, evolving from monochrome to more recently incorporating color imaging. Complementing SvP images obtained via FIM, deep learning techniques have recently been employed successfully for stress source identification of monochrome SvPs. In this study, we explore the potential of color FIM to enhance the characterization of stress sources in SvPs. To achieve this, we curate a new dataset comprising 16,000 SvPs from eight commercial monoclonal antibodies subjected to heat and mechanical stress. Using both supervised and self-supervised convolutional neural networks, as well as vision transformers in large-scale experiments, we demonstrate that deep learning with color FIM images consistently outperforms monochrome images, thus highlighting the potential of color FIM in stress source classification compared to its monochrome counterparts.
AI in Oncology: Transforming Cancer Detection through Machine Learning and Deep Learning Applications
Authors: Muhammad Aftab, Faisal Mehmood, Chengjuan Zhang, Alishba Nadeem, Zigang Dong, Yanan Jiang, Kangdongs Liu
Date: 2025-01-26 00:00:00
Tasks: Diagnostic

Artificial intelligence (AI) has potential to revolutionize the field of oncology by enhancing the precision of cancer diagnosis, optimizing treatment strategies, and personalizing therapies for a variety of cancers. This review examines the limitations of conventional diagnostic techniques and explores the transformative role of AI in diagnosing and treating cancers such as lung, breast, colorectal, liver, stomach, esophageal, cervical, thyroid, prostate, and skin cancers. The primary objective of this paper is to highlight the significant advancements that AI algorithms have brought to oncology within the medical industry. By enabling early cancer detection, improving diagnostic accuracy, and facilitating targeted treatment delivery, AI contributes to substantial improvements in patient outcomes. The integration of AI in medical imaging, genomic analysis, and pathology enhances diagnostic precision and introduces a novel, less invasive approach to cancer screening. This not only boosts the effectiveness of medical facilities but also reduces operational costs. The study delves into the application of AI in radiomics for detailed cancer characterization, predictive analytics for identifying associated risks, and the development of algorithm-driven robots for immediate diagnosis. Furthermore, it investigates the impact of AI on addressing healthcare challenges, particularly in underserved and remote regions. The overarching goal of this platform is to support the development of expert recommendations and to provide universal, efficient diagnostic procedures. By reviewing existing research and clinical studies, this paper underscores the pivotal role of AI in improving the overall cancer care system. It emphasizes how AI-enabled systems can enhance clinical decision-making and expand treatment options, thereby underscoring the importance of AI in advancing precision oncology