pwc-archive/papers-with-abstracts huggingface dataset:
CAE-Net: Generalized Deepfake Image Detection using Convolution and Attention Mechanisms with Spatial and Frequency Domain Features
Authors: Kafi Anan, Anindya Bhattacharjee, Ashir Intesher, Kaidul Islam, Abrar Assaeem Fuad, Utsab Saha, Hafiz Imtiaz
Date: 2025-02-15 00:00:00
Tasks: DeepFake Detection, Face Swapping

Effective deepfake detection tools are becoming increasingly essential to the growing usage of deepfakes in unethical practices. There exists a wide range of deepfake generation techniques, which makes it challenging to develop an accurate universal detection mechanism. The 2025 IEEE Signal Processing Cup (\textit{DFWild-Cup} competition) provided a diverse dataset of deepfake images containing significant class imbalance. The images in the dataset are generated from multiple deepfake image generators, for training machine learning model(s) to emphasize the generalization of deepfake detection. To this end, we proposed a disjoint set-based multistage training method to address the class imbalance and devised an ensemble-based architecture \emph{CAE-Net}. Our architecture consists of a convolution- and attention-based ensemble network, and employs three different neural network architectures: EfficientNet, Data-Efficient Image Transformer (DeiT), and ConvNeXt with wavelet transform to capture both local and global features of deepfakes. We visualize the specific regions that these models focus on for classification using Grad-CAM, and empirically demonstrate the effectiveness of these models in grouping real and fake images into cohesive clusters using t-SNE plots. Individually, the EfficientNet B0 architecture has achieved 90.79\% accuracy, whereas the ConvNeXt and the DeiT architecture have achieved 89.49\% and 89.32\% accuracy, respectively. With these networks, our weighted ensemble model achieves an excellent accuracy of 94.63\% on the validation dataset of the SP Cup 2025 competition. The equal error rate of 4.72\% and the Area Under the ROC curve of 97.37\% further confirm the stability of our proposed method. Finally, the robustness of our proposed model against adversarial perturbation attacks is tested as well, showing the inherent defensive properties of the ensemble approach.
Towards Zero-Shot Task-Generalizable Learning on fMRI
Authors: Jiyao Wang, Nicha C. Dvornek, Peiyu Duan, Lawrence H. Staib, James S. Duncan
Date: 2025-02-15 00:00:00

Functional MRI measuring BOLD signal is an increasingly important imaging modality in studying brain functions and neurological disorders. It can be acquired in either a resting-state or a task-based paradigm. Compared to resting-state fMRI, task-based fMRI is acquired while the subject is performing a specific task designed to enhance study-related brain activities. Consequently, it generally has more informative task-dependent signals. However, due to the variety of task designs, it is much more difficult than in resting state to aggregate task-based fMRI acquired in different tasks to train a generalizable model. To resolve this complication, we propose a supervised task-aware network TA-GAT that jointly learns a general-purpose encoder and task-specific contextual information. The encoder-generated embedding and the learned contextual information are then combined as input to multiple modules for performing downstream tasks. We believe that the proposed task-aware architecture can plug-and-play in any neural network architecture to incorporate the prior knowledge of fMRI tasks into capturing functional brain patterns.
Deep Learning for Wound Tissue Segmentation: A Comprehensive Evaluation using A Novel Dataset
Authors: Muhammad Ashad Kabir, Nidita Roy, Md. Ekramul Hossain, Jill Featherston, Sayed Ahmed
Date: 2025-02-15 00:00:00
Tasks: Image Segmentation, Segmentation, Semantic Segmentation

Deep learning (DL) techniques have emerged as promising solutions for medical wound tissue segmentation. However, a notable limitation in this field is the lack of publicly available labelled datasets and a standardised performance evaluation of state-of-the-art DL models on such datasets. This study addresses this gap by comprehensively evaluating various DL models for wound tissue segmentation using a novel dataset. We have curated a dataset comprising 147 wound images exhibiting six tissue types: slough, granulation, maceration, necrosis, bone, and tendon. The dataset was meticulously labelled for semantic segmentation employing supervised machine learning techniques. Three distinct labelling formats were developed -- full image, patch, and superpixel. Our investigation encompassed a wide array of DL segmentation and classification methodologies, ranging from conventional approaches like UNet, to generative adversarial networks such as cGAN, and modified techniques like FPN+VGG16. Also, we explored DL-based classification methods (e.g., ResNet50) and machine learning-based classification leveraging DL features (e.g., AlexNet+RF). In total, 82 wound tissue segmentation models were derived across the three labelling formats. Our analysis yielded several notable findings, including identifying optimal DL models for each labelling format based on weighted average Dice or F1 scores. Notably, FPN+VGG16 emerged as the top-performing DL model for wound tissue segmentation, achieving a dice score of 82.25%. This study provides a valuable benchmark for evaluating wound image segmentation and classification models, offering insights to inform future research and clinical practice in wound care. The labelled dataset created in this study is available at https://github.com/akabircs/WoundTissue.
SAMRI-2: A Memory-based Model for Cartilage and Meniscus Segmentation in 3D MRIs of the Knee Joint
Authors: Danielle L. Ferreira, Bruno A. A. Nunes, Xuzhe Zhang, Laura Carretero Gomez, Maggie Fung, Ravi Soni
Date: 2025-02-14 00:00:00
Tasks: MRI segmentation, Segmentation

Accurate morphometric assessment of cartilage-such as thickness/volume-via MRI is essential for monitoring knee osteoarthritis. Segmenting cartilage remains challenging and dependent on extensive expert-annotated datasets, which are heavily subjected to inter-reader variability. Recent advancements in Visual Foundational Models (VFM), especially memory-based approaches, offer opportunities for improving generalizability and robustness. This study introduces a deep learning (DL) method for cartilage and meniscus segmentation from 3D MRIs using interactive, memory-based VFMs. To improve spatial awareness and convergence, we incorporated a Hybrid Shuffling Strategy (HSS) during training and applied a segmentation mask propagation technique to enhance annotation efficiency. We trained four AI models-a CNN-based 3D-VNet, two automatic transformer-based models (SaMRI2D and SaMRI3D), and a transformer-based promptable memory-based VFM (SAMRI-2)-on 3D knee MRIs from 270 patients using public and internal datasets and evaluated on 57 external cases, including multi-radiologist annotations and different data acquisitions. Model performance was assessed against reference standards using Dice Score (DSC) and Intersection over Union (IoU), with additional morphometric evaluations to further quantify segmentation accuracy. SAMRI-2 model, trained with HSS, outperformed all other models, achieving an average DSC improvement of 5 points, with a peak improvement of 12 points for tibial cartilage. It also demonstrated the lowest cartilage thickness errors, reducing discrepancies by up to threefold. Notably, SAMRI-2 maintained high performance with as few as three user clicks per volume, reducing annotation effort while ensuring anatomical precision. This memory-based VFM with spatial awareness offers a novel approach for reliable AI-assisted knee MRI segmentation, advancing DL in musculoskeletal imaging.
SegX: Improving Interpretability of Clinical Image Diagnosis with Segmentation-based Enhancement
Authors: Yuhao Zhang, Mingcheng Zhu, Zhiyao Luo
Date: 2025-02-14 00:00:00
Tasks: Decision Making, Medical Image Analysis, Segmentation

Deep learning-based medical image analysis faces a significant barrier due to the lack of interpretability. Conventional explainable AI (XAI) techniques, such as Grad-CAM and SHAP, often highlight regions outside clinical interests. To address this issue, we propose Segmentation-based Explanation (SegX), a plug-and-play approach that enhances interpretability by aligning the model's explanation map with clinically relevant areas leveraging the power of segmentation models. Furthermore, we introduce Segmentation-based Uncertainty Assessment (SegU), a method to quantify the uncertainty of the prediction model by measuring the 'distance' between interpretation maps and clinically significant regions. Our experiments on dermoscopic and chest X-ray datasets show that SegX improves interpretability consistently across mortalities, and the certainty score provided by SegU reliably reflects the correctness of the model's predictions. Our approach offers a model-agnostic enhancement to medical image diagnosis towards reliable and interpretable AI in clinical decision-making.
Towards Patient-Specific Surgical Planning for Bicuspid Aortic Valve Repair: Fully Automated Segmentation of the Aortic Valve in 4D CT
Authors: Zaiyang Guo, Ningjun J Dong, Harold Litt, Natalie Yushkevich, Melanie Freas, Jessica Nunez, Victor Ferrari, Jilei Hao, Shir Goldfinger, Matthew A. Jolley, Joseph Bavaria, Nimesh Desai, Alison M. Pouch
Date: 2025-02-13 00:00:00
Tasks: Computed Tomography (CT), Segmentation, Temporal Sequences

The bicuspid aortic valve (BAV) is the most prevalent congenital heart defect and may require surgery for complications such as stenosis, regurgitation, and aortopathy. BAV repair surgery is effective but challenging due to the heterogeneity of BAV morphology. Multiple imaging modalities can be employed to assist the quantitative assessment of BAVs for surgical planning. Contrast-enhanced 4D computed tomography (CT) produces volumetric temporal sequences with excellent contrast and spatial resolution. Segmentation of the aortic cusps and root in these images is an essential step in creating patient specific models for visualization and quantification. While deep learning-based methods are capable of fully automated segmentation, no BAV-specific model exists. Among valve segmentation studies, there has been limited quantitative assessment of the clinical usability of the segmentation results. In this work, we developed a fully auto- mated multi-label BAV segmentation pipeline based on nnU-Net. The predicted segmentations were used to carry out surgically relevant morphological measurements including geometric cusp height, commissural angle and annulus diameter, and the results were compared against manual segmentation. Automated segmentation achieved average Dice scores of over 0.7 and symmetric mean distance below 0.7 mm for all three aortic cusps and the root wall. Clinically relevant benchmarks showed good consistency between manual and predicted segmentations. Overall, fully automated BAV segmentation of 3D frames in 4D CT can produce clinically usable measurements for surgical risk stratification, but the temporal consistency of segmentations needs to be improved.
Acute Lymphoblastic Leukemia Diagnosis Employing YOLOv11, YOLOv8, ResNet50, and Inception-ResNet-v2 Deep Learning Models
Authors: Alaa Awad, Salah A. Aly
Date: 2025-02-13 00:00:00
Tasks: All

Thousands of individuals succumb annually to leukemia alone. As artificial intelligence-driven technologies continue to evolve and advance, the question of their applicability and reliability remains unresolved. This study aims to utilize image processing and deep learning methodologies to achieve state-of-the-art results for the detection of Acute Lymphoblastic Leukemia (ALL) using data that best represents real-world scenarios. ALL is one of several types of blood cancer, and it is an aggressive form of leukemia. In this investigation, we examine the most recent advancements in ALL detection, as well as the latest iteration of the YOLO series and its performance. We address the question of whether white blood cells are malignant or benign. Additionally, the proposed models can identify different ALL stages, including early stages. Furthermore, these models can detect hematogones despite their frequent misclassification as ALL. By utilizing advanced deep learning models, namely, YOLOv8, YOLOv11, ResNet50 and Inception-ResNet-v2, the study achieves accuracy rates as high as 99.7%, demonstrating the effectiveness of these algorithms across multiple datasets and various real-world situations.
Automated Muscle and Fat Segmentation in Computed Tomography for Comprehensive Body Composition Analysis
Authors: Yaqian Chen, Hanxue Gu, YuWen Chen, Jicheng Yang, Haoyu Dong, Joseph Y. Cao, Adrian Camarena, Christopher Mantyh, Roy Colglazier, Maciej A. Mazurowski
Date: 2025-02-13 00:00:00
Tasks: Segmentation

Body composition assessment using CT images can potentially be used for a number of clinical applications, including the prognostication of cardiovascular outcomes, evaluation of metabolic health, monitoring of disease progression, assessment of nutritional status, prediction of treatment response in oncology, and risk stratification for surgical and critical care outcomes. While multiple groups have developed in-house segmentation tools for this analysis, there are very limited publicly available tools that could be consistently used across different applications. To mitigate this gap, we present a publicly accessible, end-to-end segmentation and feature calculation model specifically for CT body composition analysis. Our model performs segmentation of skeletal muscle, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) across the chest, abdomen, and pelvis area in axial CT images. It also provides various body composition metrics, including muscle density, visceral-to-subcutaneous fat (VAT/SAT) ratio, muscle area/volume, and skeletal muscle index (SMI), supporting both 2D and 3D assessments. To evaluate the model, the segmentation was applied to both internal and external datasets, with body composition metrics analyzed across different age, sex, and race groups. The model achieved high dice coefficients on both internal and external datasets, exceeding 89% for skeletal muscle, SAT, and VAT segmentation. The model outperforms the benchmark by 2.40% on skeletal muscle and 10.26% on SAT compared to the manual annotations given by the publicly available dataset. Body composition metrics show mean relative absolute errors (MRAEs) under 10% for all measures. Furthermore, the model provided muscular fat segmentation with a Dice coefficient of 56.27%, which can be utilized for additional analyses as needed.
Lifespan tree of brain anatomy: diagnostic values for motor and cognitive neurodegenerative diseases
Authors: Pierrick Coupé, Boris Mansencal, José V. Manjón, Patrice Péran, Wassilios G. Meissner, Thomas Tourdias, Vincent Planche
Date: 2025-02-13 00:00:00
Tasks: Anatomy, Diagnostic, Dimensionality Reduction

The differential diagnosis of neurodegenerative diseases, characterized by overlapping symptoms, may be challenging. Brain imaging coupled with artificial intelligence has been previously proposed for diagnostic support, but most of these methods have been trained to discriminate only isolated diseases from controls. Here, we develop a novel machine learning framework, named lifespan tree of brain anatomy, dedicated to the differential diagnosis between multiple diseases simultaneously. It integrates the modeling of volume changes for 124 brain structures during the lifespan with non-linear dimensionality reduction and synthetic sampling techniques to create easily interpretable representations of brain anatomy over the course of disease progression. As clinically relevant proof- of-concept applications, we constructed a cognitive lifespan tree of brain anatomy for the differential diagnosis of six causes of neurodegenerative dementia and a motor lifespan tree of brain anatomy for the differential diagnosis of four causes of parkinsonism using 37594 MRI as a training dataset. This original approach enhanced significantly the efficiency of differential diagnosis in the external validation cohort of 1754 cases, outperforming existing state-of-the art machine learning techniques. Lifespan tree holds promise as a valuable tool for differential diagnostic in relevant clinical conditions, especially for diseases still lacking effective biological markers.
Generalizable Cervical Cancer Screening via Large-scale Pretraining and Test-Time Adaptation
Authors: Hao Jiang, Cheng Jin, Huangjing Lin, Yanning Zhou, Xi Wang, Jiabo Ma, Li Ding, Jun Hou, Runsheng Liu, Zhizhong Chai, Luyang Luo, Huijuan Shi, Yinling Qian, Qiong Wang, Changzhong Li, Anjia Han, Ronald Cheong Kin Chan, Hao Chen
Date: 2025-02-12 00:00:00
Tasks: Sensitivity, Test-time Adaptation, whole slide images

Cervical cancer is a leading malignancy in female reproductive system. While AI-assisted cytology offers a cost-effective and non-invasive screening solution, current systems struggle with generalizability in complex clinical scenarios. To address this issue, we introduced Smart-CCS, a generalizable Cervical Cancer Screening paradigm based on pretraining and adaptation to create robust and generalizable screening systems. To develop and validate Smart-CCS, we first curated a large-scale, multi-center dataset named CCS-127K, which comprises a total of 127,471 cervical cytology whole-slide images collected from 48 medical centers. By leveraging large-scale self-supervised pretraining, our CCS models are equipped with strong generalization capability, potentially generalizing across diverse scenarios. Then, we incorporated test-time adaptation to specifically optimize the trained CCS model for complex clinical settings, which adapts and refines predictions, improving real-world applicability. We conducted large-scale system evaluation among various cohorts. In retrospective cohorts, Smart-CCS achieved an overall area under the curve (AUC) value of 0.965 and sensitivity of 0.913 for cancer screening on 11 internal test datasets. In external testing, system performance maintained high at 0.950 AUC across 6 independent test datasets. In prospective cohorts, our Smart-CCS achieved AUCs of 0.947, 0.924, and 0.986 in three prospective centers, respectively. Moreover, the system demonstrated superior sensitivity in diagnosing cervical cancer, confirming the accuracy of our cancer screening results by using histology findings for validation. Interpretability analysis with cell and slide predictions further indicated that the system's decision-making aligns with clinical practice. Smart-CCS represents a significant advancement in cancer screening across diverse clinical contexts.
Towards Fine-grained Interactive Segmentation in Images and Videos
Authors: Yuan YAO, Qiushi Yang, Miaomiao Cui, Liefeng Bo
Date: 2025-02-12 00:00:00
Tasks: Interactive Segmentation, Segmentation

The recent Segment Anything Models (SAMs) have emerged as foundational visual models for general interactive segmentation. Despite demonstrating robust generalization abilities, they still suffer performance degradations in scenarios demanding accurate masks. Existing methods for high-precision interactive segmentation face a trade-off between the ability to perceive intricate local details and maintaining stable prompting capability, which hinders the applicability and effectiveness of foundational segmentation models. To this end, we present an SAM2Refiner framework built upon the SAM2 backbone. This architecture allows SAM2 to generate fine-grained segmentation masks for both images and videos while preserving its inherent strengths. Specifically, we design a localization augment module, which incorporates local contextual cues to enhance global features via a cross-attention mechanism, thereby exploiting potential detailed patterns and maintaining semantic information. Moreover, to strengthen the prompting ability toward the enhanced object embedding, we introduce a prompt retargeting module to renew the embedding with spatially aligned prompt features. In addition, to obtain accurate high resolution segmentation masks, a mask refinement module is devised by employing a multi-scale cascaded structure to fuse mask features with hierarchical representations from the encoder. Extensive experiments demonstrate the effectiveness of our approach, revealing that the proposed method can produce highly precise masks for both images and videos, surpassing state-of-the-art methods.
Multi-Omics Fusion with Soft Labeling for Enhanced Prediction of Distant Metastasis in Nasopharyngeal Carcinoma Patients after Radiotherapy
Authors: Jiabao Sheng, SaiKit Lam, Jiang Zhang, Yuanpeng Zhang, Jing Cai
Date: 2025-02-12 00:00:00

Omics fusion has emerged as a crucial preprocessing approach in the field of medical image processing, providing significant assistance to several studies. One of the challenges encountered in the integration of omics data is the presence of unpredictability arising from disparities in data sources and medical imaging equipment. In order to overcome this challenge and facilitate the integration of their joint application to specific medical objectives, this study aims to develop a fusion methodology that mitigates the disparities inherent in omics data. The utilization of the multi-kernel late-fusion method has gained significant popularity as an effective strategy for addressing this particular challenge. An efficient representation of the data may be achieved by utilizing a suitable single-kernel function to map the inherent features and afterward merging them in a space with a high number of dimensions. This approach effectively addresses the differences noted before. The inflexibility of label fitting poses a constraint on the use of multi-kernel late-fusion methods in complex nasopharyngeal carcinoma (NPC) datasets, hence affecting the efficacy of general classifiers in dealing with high-dimensional characteristics. This innovative methodology aims to increase the disparity between the two cohorts, hence providing a more flexible structure for the allocation of labels. The examination of the NPC-ContraParotid dataset demonstrates the model's robustness and efficacy, indicating its potential as a valuable tool for predicting distant metastases in patients with nasopharyngeal carcinoma (NPC).
Heterogeneous Mixture of Experts for Remote Sensing Image Super-Resolution
Authors: Bowen Chen, Keyan Chen, Mohan Yang, Zhengxia Zou, Zhenwei Shi
Date: 2025-02-12 00:00:00
Tasks: Image Super-Resolution, Mixture-of-Experts, Super-Resolution

Remote sensing image super-resolution (SR) aims to reconstruct high-resolution remote sensing images from low-resolution inputs, thereby addressing limitations imposed by sensors and imaging conditions. However, the inherent characteristics of remote sensing images, including diverse ground object types and complex details, pose significant challenges to achieving high-quality reconstruction. Existing methods typically employ a uniform structure to process various types of ground objects without distinction, making it difficult to adapt to the complex characteristics of remote sensing images. To address this issue, we introduce a Mixture of Experts (MoE) model and design a set of heterogeneous experts. These experts are organized into multiple expert groups, where experts within each group are homogeneous while being heterogeneous across groups. This design ensures that specialized activation parameters can be employed to handle the diverse and intricate details of ground objects effectively. To better accommodate the heterogeneous experts, we propose a multi-level feature aggregation strategy to guide the routing process. Additionally, we develop a dual-routing mechanism to adaptively select the optimal expert for each pixel. Experiments conducted on the UCMerced and AID datasets demonstrate that our proposed method achieves superior SR reconstruction accuracy compared to state-of-the-art methods. The code will be available at https://github.com/Mr-Bamboo/MFG-HMoE.