pwc-archive/papers-with-abstracts huggingface dataset:
Comparative Analysis of Machine Learning Models for Lung Cancer Mutation Detection and Staging Using 3D CT Scans
Authors: Yiheng Li, Francisco Carrillo-Perez, Mohammed Alawad, Olivier Gevaert
Date: 2025-05-28 00:00:00
Tasks: Multiple Instance Learning

Lung cancer is the leading cause of cancer mortality worldwide, and non-invasive methods for detecting key mutations and staging are essential for improving patient outcomes. Here, we compare the performance of two machine learning models - FMCIB+XGBoost, a supervised model with domain-specific pretraining, and Dinov2+ABMIL, a self-supervised model with attention-based multiple-instance learning - on 3D lung nodule data from the Stanford Radiogenomics and Lung-CT-PT-Dx cohorts. In the task of KRAS and EGFR mutation detection, FMCIB+XGBoost consistently outperformed Dinov2+ABMIL, achieving accuracies of 0.846 and 0.883 for KRAS and EGFR mutations, respectively. In cancer staging, Dinov2+ABMIL demonstrated competitive generalization, achieving an accuracy of 0.797 for T-stage prediction in the Lung-CT-PT-Dx cohort, suggesting SSL's adaptability across diverse datasets. Our results emphasize the clinical utility of supervised models in mutation detection and highlight the potential of SSL to improve staging generalization, while identifying areas for enhancement in mutation sensitivity.
Multipath cycleGAN for harmonization of paired and unpaired low-dose lung computed tomography reconstruction kernels
Authors: Aravind R. Krishnan, Thomas Z. Li, Lucas W. Remedios, Michael E. Kim, Chenyu Gao, Gaurav Rudravaram, Elyssa M. McMaster, Adam M. Saunders, Shunxing Bao, Kaiwen Xu, Lianrui Zuo, Kim L. Sandler, Fabien Maldonado, Yuankai Huo, Bennett A. Landman
Date: 2025-05-28 00:00:00
Tasks: Anatomy, Computed Tomography (CT)

Reconstruction kernels in computed tomography (CT) affect spatial resolution and noise characteristics, introducing systematic variability in quantitative imaging measurements such as emphysema quantification. Choosing an appropriate kernel is therefore essential for consistent quantitative analysis. We propose a multipath cycleGAN model for CT kernel harmonization, trained on a mixture of paired and unpaired data from a low-dose lung cancer screening cohort. The model features domain-specific encoders and decoders with a shared latent space and uses discriminators tailored for each domain.We train the model on 42 kernel combinations using 100 scans each from seven representative kernels in the National Lung Screening Trial (NLST) dataset. To evaluate performance, 240 scans from each kernel are harmonized to a reference soft kernel, and emphysema is quantified before and after harmonization. A general linear model assesses the impact of age, sex, smoking status, and kernel on emphysema. We also evaluate harmonization from soft kernels to a reference hard kernel. To assess anatomical consistency, we compare segmentations of lung vessels, muscle, and subcutaneous adipose tissue generated by TotalSegmentator between harmonized and original images. Our model is benchmarked against traditional and switchable cycleGANs. For paired kernels, our approach reduces bias in emphysema scores, as seen in Bland-Altman plots (p<0.05). For unpaired kernels, harmonization eliminates confounding differences in emphysema (p>0.05). High Dice scores confirm preservation of muscle and fat anatomy, while lung vessel overlap remains reasonable. Overall, our shared latent space multipath cycleGAN enables robust harmonization across paired and unpaired CT kernels, improving emphysema quantification and preserving anatomical fidelity.
ConfLUNet: Multiple sclerosis lesion instance segmentation in presence of confluent lesions
Authors: Maxence Wynen, Pedro M. Gordaliza, Maxime Istasse, Anna Stölting, Pietro Maggi, Benoît Macq, Meritxell Bach Cuadra
Date: 2025-05-28 00:00:00
Tasks: Instance Segmentation, Lesion Detection, Prognosis, Segmentation, Semantic Segmentation

Accurate lesion-level segmentation on MRI is critical for multiple sclerosis (MS) diagnosis, prognosis, and disease monitoring. However, current evaluation practices largely rely on semantic segmentation post-processed with connected components (CC), which cannot separate confluent lesions (aggregates of confluent lesion units, CLUs) due to reliance on spatial connectivity. To address this misalignment with clinical needs, we introduce formal definitions of CLUs and associated CLU-aware detection metrics, and include them in an exhaustive instance segmentation evaluation framework. Within this framework, we systematically evaluate CC and post-processing-based Automated Confluent Splitting (ACLS), the only existing methods for lesion instance segmentation in MS. Our analysis reveals that CC consistently underestimates CLU counts, while ACLS tends to oversplit lesions, leading to overestimated lesion counts and reduced precision. To overcome these limitations, we propose ConfLUNet, the first end-to-end instance segmentation framework for MS lesions. ConfLUNet jointly optimizes lesion detection and delineation from a single FLAIR image. Trained on 50 patients, ConfLUNet significantly outperforms CC and ACLS on the held-out test set (n=13) in instance segmentation (Panoptic Quality: 42.0% vs. 37.5%/36.8%; p = 0.017/0.005) and lesion detection (F1: 67.3% vs. 61.6%/59.9%; p = 0.028/0.013). For CLU detection, ConfLUNet achieves the highest F1[CLU] (81.5%), improving recall over CC (+12.5%, p = 0.015) and precision over ACLS (+31.2%, p = 0.003). By combining rigorous definitions, new CLU-aware metrics, a reproducible evaluation framework, and the first dedicated end-to-end model, this work lays the foundation for lesion instance segmentation in MS.
Surf2CT: Cascaded 3D Flow Matching Models for Torso 3D CT Synthesis from Skin Surface
Authors: Siyeop Yoon, Yujin Oh, Pengfei Jin, Sifan Song, Matthew Tivnan, Dufan Wu, Xiang Li, Quanzheng Li
Date: 2025-05-28 00:00:00
Tasks: Anatomy, Computed Tomography (CT), Super-Resolution

We present Surf2CT, a novel cascaded flow matching framework that synthesizes full 3D computed tomography (CT) volumes of the human torso from external surface scans and simple demographic data (age, sex, height, weight). This is the first approach capable of generating realistic volumetric internal anatomy images solely based on external body shape and demographics, without any internal imaging. Surf2CT proceeds through three sequential stages: (1) Surface Completion, reconstructing a complete signed distance function (SDF) from partial torso scans using conditional 3D flow matching; (2) Coarse CT Synthesis, generating a low-resolution CT volume from the completed SDF and demographic information; and (3) CT Super-Resolution, refining the coarse volume into a high-resolution CT via a patch-wise conditional flow model. Each stage utilizes a 3D-adapted EDM2 backbone trained via flow matching. We trained our model on a combined dataset of 3,198 torso CT scans (approximately 1.13 million axial slices) sourced from Massachusetts General Hospital (MGH) and the AutoPET challenge. Evaluation on 700 paired torso surface-CT cases demonstrated strong anatomical fidelity: organ volumes exhibited small mean percentage differences (range from -11.1% to 4.4%), and muscle/fat body composition metrics matched ground truth with strong correlation (range from 0.67 to 0.96). Lung localization had minimal bias (mean difference -2.5 mm), and surface completion significantly improved metrics (Chamfer distance: from 521.8 mm to 2.7 mm; Intersection-over-Union: from 0.87 to 0.98). Surf2CT establishes a new paradigm for non-invasive internal anatomical imaging using only external data, opening opportunities for home-based healthcare, preventive medicine, and personalized clinical assessments without the risks associated with conventional imaging techniques.
Risk-Sensitive Conformal Prediction for Catheter Placement Detection in Chest X-rays
Authors: Long Hui
Date: 2025-05-28 00:00:00
Tasks: Conformal Prediction, Multi-Task Learning, Prediction

This paper presents a novel approach to catheter and line position detection in chest X-rays, combining multi-task learning with risk-sensitive conformal prediction to address critical clinical requirements. Our model simultaneously performs classification, segmentation, and landmark detection, leveraging the synergistic relationship between these tasks to improve overall performance. We further enhance clinical reliability through risk-sensitive conformal prediction, which provides statistically guaranteed prediction sets with higher reliability for clinically critical findings. Experimental results demonstrate excellent performance with 90.68\% overall empirical coverage and 99.29\% coverage for critical conditions, while maintaining remarkable precision in prediction sets. Most importantly, our risk-sensitive approach achieves zero high-risk mispredictions (cases where the system dangerously declares problematic tubes as confidently normal), making the system particularly suitable for clinical deployment. This work offers both accurate predictions and reliably quantified uncertainty -- essential features for life-critical medical applications.
MONSTR: Model-Oriented Neutron Strain Tomographic Reconstruction
Authors: Mohammad Samin Nur Chowdhury, Shimin Tang, Singanallur V. Venkatakrishnan, Hassina Z. Bilheux, Gregery T. Buzzard, Charles A. Bouman
Date: 2025-05-28 00:00:00
Tasks: model

Residual strain, a tensor quantity, is a critical material property that impacts the overall performance of metal parts. Neutron Bragg edge strain tomography is a technique for imaging residual strain that works by making conventional hyperspectral computed tomography measurements, extracting the average projected strain at each detector pixel, and processing the resulting strain sinogram using a reconstruction algorithm. However, the reconstruction is severely ill-posed as the underlying inverse problem involves inferring a tensor at each voxel from scalar sinogram data. In this paper, we introduce the model-oriented neutron strain tomographic reconstruction (MONSTR) algorithm that reconstructs the 2D residual strain tensor from the neutron Bragg edge strain measurements. MONSTR is based on using the multi-agent consensus equilibrium framework for the tensor tomographic reconstruction. Specifically, we formulate the reconstruction as a consensus solution of a collection of agents representing detector physics, the tomographic reconstruction process, and physics-based constraints from continuum mechanics. Using simulated data, we demonstrate high-quality reconstruction of the strain tensor even when using very few measurements.
High Volume Rate 3D Ultrasound Reconstruction with Diffusion Models
Authors: Tristan S. W. Stevens, Oisín Nolan, Oudom Somphone, Jean-Luc Robert, Ruud J. G. van Sloun
Date: 2025-05-28 00:00:00

Three-dimensional ultrasound enables real-time volumetric visualization of anatomical structures. Unlike traditional 2D ultrasound, 3D imaging reduces the reliance on precise probe orientation, potentially making ultrasound more accessible to clinicians with varying levels of experience and improving automated measurements and post-exam analysis. However, achieving both high volume rates and high image quality remains a significant challenge. While 3D diverging waves can provide high volume rates, they suffer from limited tissue harmonic generation and increased multipath effects, which degrade image quality. One compromise is to retain the focusing in elevation while leveraging unfocused diverging waves in the lateral direction to reduce the number of transmissions per elevation plane. Reaching the volume rates achieved by full 3D diverging waves, however, requires dramatically undersampling the number of elevation planes. Subsequently, to render the full volume, simple interpolation techniques are applied. This paper introduces a novel approach to 3D ultrasound reconstruction from a reduced set of elevation planes by employing diffusion models (DMs) to achieve increased spatial and temporal resolution. We compare both traditional and supervised deep learning-based interpolation methods on a 3D cardiac ultrasound dataset. Our results show that DM-based reconstruction consistently outperforms the baselines in image quality and downstream task performance. Additionally, we accelerate inference by leveraging the temporal consistency inherent to ultrasound sequences. Finally, we explore the robustness of the proposed method by exploiting the probabilistic nature of diffusion posterior sampling to quantify reconstruction uncertainty and demonstrate improved recall on out-of-distribution data with synthetic anomalies under strong subsampling.
Learnable Burst-Encodable Time-of-Flight Imaging for High-Fidelity Long-Distance Depth Sensing
Authors: Manchao Bao, Shengjiang Fang, Tao Yue, Xuemei Hu
Date: 2025-05-28 00:00:00
Tasks: Autonomous Driving

Long-distance depth imaging holds great promise for applications such as autonomous driving and robotics. Direct time-of-flight (dToF) imaging offers high-precision, long-distance depth sensing, yet demands ultra-short pulse light sources and high-resolution time-to-digital converters. In contrast, indirect time-of-flight (iToF) imaging often suffers from phase wrapping and low signal-to-noise ratio (SNR) as the sensing distance increases. In this paper, we introduce a novel ToF imaging paradigm, termed Burst-Encodable Time-of-Flight (BE-ToF), which facilitates high-fidelity, long-distance depth imaging. Specifically, the BE-ToF system emits light pulses in burst mode and estimates the phase delay of the reflected signal over the entire burst period, thereby effectively avoiding the phase wrapping inherent to conventional iToF systems. Moreover, to address the low SNR caused by light attenuation over increasing distances, we propose an end-to-end learnable framework that jointly optimizes the coding functions and the depth reconstruction network. A specialized double well function and first-order difference term are incorporated into the framework to ensure the hardware implementability of the coding functions. The proposed approach is rigorously validated through comprehensive simulations and real-world prototype experiments, demonstrating its effectiveness and practical applicability.
Collaborative Learning for Unsupervised Multimodal Remote Sensing Image Registration: Integrating Self-Supervision and MIM-Guided Diffusion-Based Image Translation
Authors: Xiaochen Wei, Weiwei Guo, Wenxian Yu
Date: 2025-05-28 00:00:00
Tasks: Image Registration, Pseudo Label

The substantial modality-induced variations in radiometric, texture, and structural characteristics pose significant challenges for the accurate registration of multimodal images. While supervised deep learning methods have demonstrated strong performance, they often rely on large-scale annotated datasets, limiting their practical application. Traditional unsupervised methods usually optimize registration by minimizing differences in feature representations, yet often fail to robustly capture geometric discrepancies, particularly under substantial spatial and radiometric variations, thus hindering convergence stability. To address these challenges, we propose a Collaborative Learning framework for Unsupervised Multimodal Image Registration, named CoLReg, which reformulates unsupervised registration learning into a collaborative training paradigm comprising three components: (1) a cross-modal image translation network, MIMGCD, which employs a learnable Maximum Index Map (MIM) guided conditional diffusion model to synthesize modality-consistent image pairs; (2) a self-supervised intermediate registration network which learns to estimate geometric transformations using accurate displacement labels derived from MIMGCD outputs; (3) a distilled cross-modal registration network trained with pseudo-label predicted by the intermediate network. The three networks are jointly optimized through an alternating training strategy wherein each network enhances the performance of the others. This mutual collaboration progressively reduces modality discrepancies, enhances the quality of pseudo-labels, and improves registration accuracy. Extensive experimental results on multiple datasets demonstrate that our ColReg achieves competitive or superior performance compared to state-of-the-art unsupervised approaches and even surpasses several supervised baselines.
Subspecialty-Specific Foundation Model for Intelligent Gastrointestinal Pathology
Authors: Lianghui Zhu, Xitong Ling, Minxi Ouyang, Xiaoping Liu, Tian Guan, Mingxi Fu, Zhiqiang Cheng, Fanglei Fu, Maomao Zeng, LiMing Liu, Song Duan, Qiang Huang, Ying Xiao, Jianming Li, Shanming Lu, Zhenghua Piao, Mingxi Zhu, Yibo Jin, Shan Xu, Qiming He, Yizhi Wang, Junru Cheng, XuanYu Wang, Luxi Xie, Houqiang Li, Sufang Tian, Yonghong He
Date: 2025-05-28 00:00:00
Tasks: Diagnostic, Prognosis, whole slide images

Gastrointestinal (GI) diseases represent a clinically significant burden, necessitating precise diagnostic approaches to optimize patient outcomes. Conventional histopathological diagnosis suffers from limited reproducibility and diagnostic variability. To overcome these limitations, we develop Digepath, a specialized foundation model for GI pathology. Our framework introduces a dual-phase iterative optimization strategy combining pretraining with fine-screening, specifically designed to address the detection of sparsely distributed lesion areas in whole-slide images. Digepath is pretrained on over 353 million multi-scale images from 210,043 H&E-stained slides of GI diseases. It attains state-of-the-art performance on 33 out of 34 tasks related to GI pathology, including pathological diagnosis, protein expression status prediction, gene mutation prediction, and prognosis evaluation. We further translate the intelligent screening module for early GI cancer and achieve near-perfect 99.70% sensitivity across nine independent medical institutions. This work not only advances AI-driven precision pathology for GI diseases but also bridge critical gaps in histopathological practice.
Patch-based Reconstruction for Unsupervised Dynamic MRI using Learnable Tensor Function with Implicit Neural Representation
Authors: Yuanyuan Liu, Yuanbiao Yang, Zhuo-Xu Cui, Qingyong Zhu, Jing Cheng, Congcong Liu, Jinwen Xie, Jingran Xu, Hairong Zheng, Dong Liang, Yanjie Zhu
Date: 2025-05-28 00:00:00
Tasks: Tensor Decomposition

Dynamic MRI plays a vital role in clinical practice by capturing both spatial details and dynamic motion, but its high spatiotemporal resolution is often limited by long scan times. Deep learning (DL)-based methods have shown promising performance in accelerating dynamic MRI. However, most existing algorithms rely on large fully-sampled datasets for training, which are difficult to acquire. Recently, implicit neural representation (INR) has emerged as a powerful scan-specific paradigm for accelerated MRI, which models signals as a continuous function over spatiotemporal coordinates. Although this approach achieves efficient continuous modeling of dynamic images and robust reconstruction, it faces challenges in recovering fine details and increasing computational demands for high dimensional data representation. To enhance both efficiency and reconstruction quality, we propose TenF-INR, a novel patch-based unsupervised framework that employs INR to model bases of tensor decomposition, enabling efficient and accurate modeling of dynamic MR images with learnable tensor functions. By exploiting strong correlations in similar spatial image patches and in the temporal direction, TenF-INR enforces multidimensional low-rankness and implements patch-based reconstruction with the benefits of continuous modeling. We compare TenF-INR with state-of-the-art methods, including supervised DL methods and unsupervised approaches. Experimental results demonstrate that TenF-INR achieves high acceleration factors up to 21, outperforming all comparison methods in image quality, temporal fidelity, and quantitative metrics, even surpassing the supervised methods.
MAMBO-NET: Multi-Causal Aware Modeling Backdoor-Intervention Optimization for Medical Image Segmentation Network
Authors: Ruiguo Yu, Yiyang Zhang, Yuan Tian, Yujie Diao, Di Jin, Witold Pedrycz
Date: 2025-05-28 00:00:00
Tasks: Causal Inference, Image Segmentation, Medical Image Segmentation, Segmentation, Semantic Segmentation

Medical image segmentation methods generally assume that the process from medical image to segmentation is unbiased, and use neural networks to establish conditional probability models to complete the segmentation task. This assumption does not consider confusion factors, which can affect medical images, such as complex anatomical variations and imaging modality limitations. Confusion factors obfuscate the relevance and causality of medical image segmentation, leading to unsatisfactory segmentation results. To address this issue, we propose a multi-causal aware modeling backdoor-intervention optimization (MAMBO-NET) network for medical image segmentation. Drawing insights from causal inference, MAMBO-NET utilizes self-modeling with multi-Gaussian distributions to fit the confusion factors and introduce causal intervention into the segmentation process. Moreover, we design appropriate posterior probability constraints to effectively train the distributions of confusion factors. For the distributions to effectively guide the segmentation and mitigate and eliminate the Impact of confusion factors on the segmentation, we introduce classical backdoor intervention techniques and analyze their feasibility in the segmentation task. To evaluate the effectiveness of our approach, we conducted extensive experiments on five medical image datasets. The results demonstrate that our method significantly reduces the influence of confusion factors, leading to enhanced segmentation accuracy.
Targeted Unlearning Using Perturbed Sign Gradient Methods With Applications On Medical Images
Authors: George R. Nahass, Zhu Wang, Homa Rashidisabet, Won Hwa Kim, Sasha Hubschman, Jeffrey C. Peterson, Ghasem Yazdanpanah, Chad A. Purnell, Pete Setabutr, Ann Q. Tran, Darvin Yi, Sathya N. Ravi
Date: 2025-05-28 00:00:00
Tasks: Bilevel Optimization, Machine Unlearning

Machine unlearning aims to remove the influence of specific training samples from a trained model without full retraining. While prior work has largely focused on privacy-motivated settings, we recast unlearning as a general-purpose tool for post-deployment model revision. Specifically, we focus on utilizing unlearning in clinical contexts where data shifts, device deprecation, and policy changes are common. To this end, we propose a bilevel optimization formulation of boundary-based unlearning that can be solved using iterative algorithms. We provide convergence guarantees when first-order algorithms are used to unlearn. Our method introduces tunable loss design for controlling the forgetting-retention tradeoff and supports novel model composition strategies that merge the strengths of distinct unlearning runs. Across benchmark and real-world clinical imaging datasets, our approach outperforms baselines on both forgetting and retention metrics, including scenarios involving imaging devices and anatomical outliers. This work establishes machine unlearning as a modular, practical alternative to retraining for real-world model maintenance in clinical applications.