pwc-archive/papers-with-abstracts huggingface dataset:
Deciphering the unique dynamic activation pathway in a G protein-coupled receptor enables unveiling biased signaling and identifying cryptic allosteric sites in conformational intermediates
Authors: Jigang Fan, Chunhao Zhu, Xiaobing Lan, Haiming Zhuang, Mingyu Li, Jian Zhang, Shaoyong Lu
Date: 2025-04-24 00:00:00

Neurotensin receptor 1 (NTSR1), a member of the Class A G protein-coupled receptor superfamily, plays an important role in modulating dopaminergic neuronal activity and eliciting opioid-independent analgesia. Recent studies suggest that promoting \{beta}-arrestin-biased signaling in NTSR1 may diminish drugs of abuse, such as psychostimulants, thereby offering a potential avenue for treating human addiction-related disorders. In this study, we utilized a novel computational and experimental approach that combined nudged elastic band-based molecular dynamics simulations, Markov state models, temporal communication network analysis, site-directed mutagenesis, and conformational biosensors, to explore the intricate mechanisms underlying NTSR1 activation and biased signaling. Our study reveals a dynamic stepwise transition mechanism and activated transmission network associated with NTSR1 activation. It also yields valuable insights into the complex interplay between the unique polar network, non-conserved ion locks, and aromatic clusters in NTSR1 signaling. Moreover, we identified a cryptic allosteric site located in the intracellular region of the receptor that exists in an intermediate state within the activation pathway. Collectively, these findings contribute to a more profound understanding of NTSR1 activation and biased signaling at the atomic level, thereby providing a potential strategy for the development of NTSR1 allosteric modulators in the realm of G protein-coupled receptor biology, biophysics, and medicine.
Mamba-Sea: A Mamba-based Framework with Global-to-Local Sequence Augmentation for Generalizable Medical Image Segmentation
Authors: Zihan Cheng, Jintao Guo, Jian Zhang, Lei Qi, Luping Zhou, Yinghuan Shi, Yang Gao
Date: 2025-04-24 00:00:00
Tasks: Domain Generalization, Image Segmentation, Mamba, Medical Image Segmentation, Semantic Segmentation, State Space Models

To segment medical images with distribution shifts, domain generalization (DG) has emerged as a promising setting to train models on source domains that can generalize to unseen target domains. Existing DG methods are mainly based on CNN or ViT architectures. Recently, advanced state space models, represented by Mamba, have shown promising results in various supervised medical image segmentation. The success of Mamba is primarily owing to its ability to capture long-range dependencies while keeping linear complexity with input sequence length, making it a promising alternative to CNNs and ViTs. Inspired by the success, in the paper, we explore the potential of the Mamba architecture to address distribution shifts in DG for medical image segmentation. Specifically, we propose a novel Mamba-based framework, Mamba-Sea, incorporating global-to-local sequence augmentation to improve the model's generalizability under domain shift issues. Our Mamba-Sea introduces a global augmentation mechanism designed to simulate potential variations in appearance across different sites, aiming to suppress the model's learning of domain-specific information. At the local level, we propose a sequence-wise augmentation along input sequences, which perturbs the style of tokens within random continuous sub-sequences by modeling and resampling style statistics associated with domain shifts. To our best knowledge, Mamba-Sea is the first work to explore the generalization of Mamba for medical image segmentation, providing an advanced and promising Mamba-based architecture with strong robustness to domain shifts. Remarkably, our proposed method is the first to surpass a Dice coefficient of 90% on the Prostate dataset, which exceeds previous SOTA of 88.61%. The code is available at https://github.com/orange-czh/Mamba-Sea.
FRAG: Frame Selection Augmented Generation for Long Video and Long Document Understanding
Authors: De-An Huang, Subhashree Radhakrishnan, Zhiding Yu, Jan Kautz
Date: 2025-04-24 00:00:00
Tasks: document understanding, MME, Video MME

There has been impressive progress in Large Multimodal Models (LMMs). Recent works extend these models to long inputs, including multi-page documents and long videos. However, the model size and performance of these long context models are still limited due to the computational cost in both training and inference. In this work, we explore an orthogonal direction and process long inputs without long context LMMs. We propose Frame Selection Augmented Generation (FRAG), where the model first selects relevant frames within the input, and then only generates the final outputs based on the selected frames. The core of the selection process is done by scoring each frame independently, which does not require long context processing. The frames with the highest scores are then selected by a simple Top-K selection. We show that this frustratingly simple framework is applicable to both long videos and multi-page documents using existing LMMs without any fine-tuning. We consider two models, LLaVA-OneVision and InternVL2, in our experiments and show that FRAG consistently improves the performance and achieves state-of-the-art performances for both long video and long document understanding. For videos, FRAG substantially improves InternVL2-76B by 5.8% on MLVU and 3.7% on Video-MME. For documents, FRAG achieves over 20% improvements on MP-DocVQA compared with recent LMMs specialized in long document understanding. Code is available at: https://github.com/NVlabs/FRAG
A Double-Norm Aggregated Tensor Latent Factorization Model for Temporal-Aware Traffic Speed Imputation
Authors: Jiawen Hou, Hao Wu
Date: 2025-04-24 00:00:00
Tasks: Imputation, Tensor Decomposition

In intelligent transportation systems (ITS), traffic management departments rely on sensors, cameras, and GPS devices to collect real-time traffic data. Traffic speed data is often incomplete due to sensor failures, data transmission delays, or occlusions, resulting in missing speed data in certain road segments. Currently, tensor decomposition based methods are extensively utilized, they mostly rely on the $L_2$-norm to construct their learning objectives, which leads to reduced robustness in the algorithms. To address this, we propose Temporal-Aware Traffic Speed Imputation (TATSI), which combines the $L_2$-norm and smooth $L_1$ (${SL}_1$)-norm in its loss function, thereby achieving both high accuracy and robust performance in imputing missing time-varying traffic speed data. TATSI adopts a single latent factor-dependent, nonnegative, and multiplicative update (SLF-NMU) approach, which serves as an efficient solver for performing nonnegative latent factor analysis (LFA) on a tensor. Empirical studies on three real-world time-varying traffic speed datasets demonstrate that, compared with state-of-the-art traffic speed predictors, TATSI more precisely captures temporal patterns, thereby yielding the most accurate imputations for missing traffic speed data.
Group Downsampling with Equivariant Anti-aliasing
Authors: Md Ashiqur Rahman, Raymond A. Yeh
Date: 2025-04-24 00:00:00
Tasks: image-classification, Image Classification

Downsampling layers are crucial building blocks in CNN architectures, which help to increase the receptive field for learning high-level features and reduce the amount of memory/computation in the model. In this work, we study the generalization of the uniform downsampling layer for group equivariant architectures, e.g., G-CNNs. That is, we aim to downsample signals (feature maps) on general finite groups with anti-aliasing. This involves the following: (a) Given a finite group and a downsampling rate, we present an algorithm to form a suitable choice of subgroup. (b) Given a group and a subgroup, we study the notion of bandlimited-ness and propose how to perform anti-aliasing. Notably, our method generalizes the notion of downsampling based on classical sampling theory. When the signal is on a cyclic group, i.e., periodic, our method recovers the standard downsampling of an ideal low-pass filter followed by a subsampling operation. Finally, we conducted experiments on image classification tasks demonstrating that the proposed downsampling operation improves accuracy, better preserves equivariance, and reduces model size when incorporated into G-equivariant networks
DIVE: Inverting Conditional Diffusion Models for Discriminative Tasks
Authors: Yinqi Li, Hong Chang, Ruibing Hou, Shiguang Shan, Xilin Chen
Date: 2025-04-24 00:00:00
Tasks: Image Classification, object-detection, Object Detection

Diffusion models have shown remarkable progress in various generative tasks such as image and video generation. This paper studies the problem of leveraging pretrained diffusion models for performing discriminative tasks. Specifically, we extend the discriminative capability of pretrained frozen generative diffusion models from the classification task to the more complex object detection task, by "inverting" a pretrained layout-to-image diffusion model. To this end, a gradient-based discrete optimization approach for replacing the heavy prediction enumeration process, and a prior distribution model for making more accurate use of the Bayes' rule, are proposed respectively. Empirical results show that this method is on par with basic discriminative object detection baselines on COCO dataset. In addition, our method can greatly speed up the previous diffusion-based method for classification without sacrificing accuracy. Code and models are available at https://github.com/LiYinqi/DIVE .
CLPSTNet: A Progressive Multi-Scale Convolutional Steganography Model Integrating Curriculum Learning
Authors: Fengchun Liu, Tong Zhang, Chunying Zhang
Date: 2025-04-23 00:00:00
Tasks: Image Steganography, SSIM, Steganalysis

In recent years, a large number of works have introduced Convolutional Neural Networks (CNNs) into image steganography, which transform traditional steganography methods such as hand-crafted features and prior knowledge design into steganography methods that neural networks autonomically learn information embedding. However, due to the inherent complexity of digital images, issues of invisibility and security persist when using CNN models for information embedding. In this paper, we propose Curriculum Learning Progressive Steganophy Network (CLPSTNet). The network consists of multiple progressive multi-scale convolutional modules that integrate Inception structures and dilated convolutions. The module contains multiple branching pathways, starting from a smaller convolutional kernel and dilatation rate, extracting the basic, local feature information from the feature map, and gradually expanding to the convolution with a larger convolutional kernel and dilatation rate for perceiving the feature information of a larger receptive field, so as to realize the multi-scale feature extraction from shallow to deep, and from fine to coarse, allowing the shallow secret information features to be refined in different fusion stages. The experimental results show that the proposed CLPSTNet not only has high PSNR , SSIM metrics and decoding accuracy on three large public datasets, ALASKA2, VOC2012 and ImageNet, but also the steganographic images generated by CLPSTNet have low steganalysis scores.You can find our code at \href{https://github.com/chaos-boops/CLPSTNet}{https://github.com/chaos-boops/CLPSTNet}.
Combining GCN Structural Learning with LLM Chemical Knowledge for or Enhanced Virtual Screening
Authors: Radia Berreziga, Mohammed Brahimi, Khairedine Kraim, Hamid Azzoune
Date: 2025-04-24 00:00:00
Tasks: Computational Efficiency, Drug Design, Drug Discovery

Virtual screening plays a critical role in modern drug discovery by enabling the identification of promising candidate molecules for experimental validation. Traditional machine learning methods such as support vector machines (SVM) and XGBoost rely on predefined molecular representations, often leading to information loss and potential bias. In contrast, deep learning approaches-particularly Graph Convolutional Networks (GCNs)-offer a more expressive and unbiased alternative by operating directly on molecular graphs. Meanwhile, Large Language Models (LLMs) have recently demonstrated state-of-the-art performance in drug design, thanks to their capacity to capture complex chemical patterns from large-scale data via attention mechanisms. In this paper, we propose a hybrid architecture that integrates GCNs with LLM-derived embeddings to combine localized structural learning with global chemical knowledge. The LLM embeddings can be precomputed and stored in a molecular feature library, removing the need to rerun the LLM during training or inference and thus maintaining computational efficiency. We found that concatenating the LLM embeddings after each GCN layer-rather than only at the final layer-significantly improves performance, enabling deeper integration of global context throughout the network. The resulting model achieves superior results, with an F1-score of (88.8%), outperforming standalone GCN (87.9%), XGBoost (85.5%), and SVM (85.4%) baselines.
CLIPSE -- a minimalistic CLIP-based image search engine for research
Authors: Steve Göring
Date: 2025-04-24 00:00:00
Tasks: Image Retrieval

A brief overview of CLIPSE, a self-hosted image search engine with the main application of research, is provided. In general, CLIPSE uses CLIP embeddings to process the images and also the text queries. The overall framework is designed with simplicity to enable easy extension and usage. Two benchmark scenarios are described and evaluated, covering indexing and querying time. It is shown that CLIPSE is capable of handling smaller datasets; for larger datasets, a distributed approach with several instances should be considered.
Skywork R1V2: Multimodal Hybrid Reinforcement Learning for Reasoning
Authors: Chris, Yichen Wei, Yi Peng, Xiaokun Wang, Weijie Qiu, Wei Shen, Tianyidan Xie, Jiangbo Pei, Jianhao Zhang, Yunzhuo Hao, Xuchen Song, Yang Liu, Yahui Zhou
Date: 2025-04-23 00:00:00
Tasks: Multimodal Reasoning, reinforcement-learning, Reinforcement Learning

We present Skywork R1V2, a next-generation multimodal reasoning model and a major leap forward from its predecessor, Skywork R1V. At its core, R1V2 introduces a hybrid reinforcement learning paradigm that harmonizes reward-model guidance with rule-based strategies, thereby addressing the long-standing challenge of balancing sophisticated reasoning capabilities with broad generalization. To further enhance training efficiency, we propose the Selective Sample Buffer (SSB) mechanism, which effectively counters the ``Vanishing Advantages'' dilemma inherent in Group Relative Policy Optimization (GRPO) by prioritizing high-value samples throughout the optimization process. Notably, we observe that excessive reinforcement signals can induce visual hallucinations--a phenomenon we systematically monitor and mitigate through calibrated reward thresholds throughout the training process. Empirical results affirm the exceptional capability of R1V2, with benchmark-leading performances such as 62.6 on OlympiadBench, 79.0 on AIME2024, 63.6 on LiveCodeBench, and 74.0 on MMMU. These results underscore R1V2's superiority over existing open-source models and demonstrate significant progress in closing the performance gap with premier proprietary systems, including Gemini 2.5 and OpenAI o4-mini. The Skywork R1V2 model weights have been publicly released to promote openness and reproducibility https://huggingface.co/Skywork/Skywork-R1V2-38B.
Latent Video Dataset Distillation
Authors: Ning li, Antai Andy Liu, Jingran Zhang, Justin Cui
Date: 2025-04-23 00:00:00
Tasks: Dataset Distillation, Diversity

Dataset distillation has demonstrated remarkable effectiveness in high-compression scenarios for image datasets. While video datasets inherently contain greater redundancy, existing video dataset distillation methods primarily focus on compression in the pixel space, overlooking advances in the latent space that have been widely adopted in modern text-to-image and text-to-video models. In this work, we bridge this gap by introducing a novel video dataset distillation approach that operates in the latent space using a state-of-the-art variational encoder. Furthermore, we employ a diversity-aware data selection strategy to select both representative and diverse samples. Additionally, we introduce a simple, training-free method to further compress the distilled latent dataset. By combining these techniques, our approach achieves a new state-of-the-art performance in dataset distillation, outperforming prior methods on all datasets, e.g. on HMDB51 IPC 1, we achieve a 2.6% performance increase; on MiniUCF IPC 5, we achieve a 7.8% performance increase.
Feature Selection Gates with Gradient Routing for Endoscopic Image Computing
Authors: Giorgio Roffo, Carlo Biffi, Pietro Salvagnini, Andrea Cherubini
Date: 2024-10-07 00:00:00
Proceeding: proceedings of Medical Image Computing and Computer Assisted Intervention -- MICCAI 2024 2024 10
Tasks: Binary Classification, Colorectal Polyps Characterization, feature selection

To address overfitting and enhance model generalization in gastroenterological polyp size assessment, our study introduces Feature Selection Gates (FSG) alongside Gradient Routing (GR) for dynamic feature selection. This technique aims to boost Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) by promoting sparse connectivity, thereby reducing overfitting and enhancing generalization. FSG achieves this through sparsification with learnable weights, serving as a regularization strategy. GR further refines this process by optimizing FSG parameters via dual forward passes, independently from the main model, to improve feature re-weighting. Our evaluation spanned multiple datasets, including CIFAR-100 for a broad impact assessment and specialized endoscopic datasets (REAL-Colon [12], Misawa [9], and SUN [13]) focusing on polyp size estimation, covering over 200 polyps in more than 370K frames. The findings indicate that our FSG-enhanced networks substantially enhance performance in both binary and triclass classification tasks related to polyp sizing. Specifically, CNNs experienced an F1 Score improvement to 87.8% in binary classification, while in triclass classification, the ViT-T model reached an F1 Score of 76.5%, outperforming traditional CNNs and ViT-T models. To facilitate further research, we are releasing our codebase, which includes implementations for CNNs, multistream CNNs, ViT, and FSG-augmented variants. This resource aims to standardize the use of endoscopic datasets, providing public training-validation-testing splits for reliable and comparable research in gastroenterological polyp size estimation. The codebase is available at github.com/cosmoimd/feature-selection-gates.
InteractVLM: 3D Interaction Reasoning from 2D Foundational Models
Authors: Sai Kumar Dwivedi, Dimitrije Antić, Shashank Tripathi, Omid Taheri, Cordelia Schmid, Michael J. Black, Dimitrios Tzionas
Date: 2025-04-07 00:00:00
Proceeding: CVPR 2025 1
Tasks: 3D Reconstruction, Object

We introduce InteractVLM, a novel method to estimate 3D contact points on human bodies and objects from single in-the-wild images, enabling accurate human-object joint reconstruction in 3D. This is challenging due to occlusions, depth ambiguities, and widely varying object shapes. Existing methods rely on 3D contact annotations collected via expensive motion-capture systems or tedious manual labeling, limiting scalability and generalization. To overcome this, InteractVLM harnesses the broad visual knowledge of large Vision-Language Models (VLMs), fine-tuned with limited 3D contact data. However, directly applying these models is non-trivial, as they reason only in 2D, while human-object contact is inherently 3D. Thus we introduce a novel Render-Localize-Lift module that: (1) embeds 3D body and object surfaces in 2D space via multi-view rendering, (2) trains a novel multi-view localization model (MV-Loc) to infer contacts in 2D, and (3) lifts these to 3D. Additionally, we propose a new task called Semantic Human Contact estimation, where human contact predictions are conditioned explicitly on object semantics, enabling richer interaction modeling. InteractVLM outperforms existing work on contact estimation and also facilitates 3D reconstruction from an in-the wild image. Code and models are available at https://interactvlm.is.tue.mpg.de.
MEDIBENG WHISPER TINY: A FINE-TUNED CODE-SWITCHED BENGALI-ENGLISH TRANSLATOR FOR CLINICAL APPLICATIONS
Authors: Promila Ghosh, Sunipun Talukder
Date: 2025-04-25 00:00:00
Proceeding: medRxiv 2025 4
Tasks: Clinical Language Translation, Machine Translation, Speech-to-Text, Speech-to-Text Translation, Synthetic Data Generation

Code-switching in multilingual healthcare settings challenges automated transcription systems as facilities adopt AI documentation tools. To tackle this issue, we developed a cost-effective solution using the MediBeng Whisper Tiny model, a fine-tuned version of the Whisper Tiny model specifically designed for code-switched Bengali-English conversations in healthcare contexts. The model was fine-tuned on MediBeng, a synthetic dataset created to simulate the types of bilingual interactions often found in healthcare environments. The fine-tuning process involved using just 20% of the dataset, making it highly efficient in terms of computational resources and data usage. Despite the limited data, our model achieved an exceptional 0.01 Word Error Rate (WER), reflecting near-perfect transcription accuracy. Additionally, the model attained a 0.98 BLEU score, indicating its ability to accurately translate mixed-language input into English. These impressive results demonstrate that even with minimal data and resources, the model can handle complex code-switching tasks effectively. This model improves information processing for healthcare professionals, allowing doctors to save time on paperwork and focus more on patient care. It also ensures patient records are more accurate and accessible, aiding better healthcare decision-making.
Distilling semantically aware orders for autoregressive image generation
Authors: Rishav Pramanik, Antoine Poupon, Juan A. Rodriguez, Masih Aminbeidokhti, David Vazquez, Christopher Pal, Zhaozheng Yin, Marco Pedersoli
Date: 2025-04-23 00:00:00
Tasks: Image Generation, Text Generation, Text-to-Image Generation

Autoregressive patch-based image generation has recently shown competitive results in terms of image quality and scalability. It can also be easily integrated and scaled within Vision-Language models. Nevertheless, autoregressive models require a defined order for patch generation. While a natural order based on the dictation of the words makes sense for text generation, there is no inherent generation order that exists for image generation. Traditionally, a raster-scan order (from top-left to bottom-right) guides autoregressive image generation models. In this paper, we argue that this order is suboptimal, as it fails to respect the causality of the image content: for instance, when conditioned on a visual description of a sunset, an autoregressive model may generate clouds before the sun, even though the color of clouds should depend on the color of the sun and not the inverse. In this work, we show that first by training a model to generate patches in any-given-order, we can infer both the content and the location (order) of each patch during generation. Secondly, we use these extracted orders to finetune the any-given-order model to produce better-quality images. Through our experiments, we show on two datasets that this new generation method produces better images than the traditional raster-scan approach, with similar training costs and no extra annotations.