pwc-archive/papers-with-abstracts huggingface dataset:
Introducing the Biomechanics-Function Relationship in Glaucoma: Improved Visual Field Loss Predictions from intraocular pressure-induced Neural Tissue Strains
Authors: Thanadet Chuangsuwanich, Monisha E. Nongpiur, Fabian A. Braeu, Tin A. Tun, Alexandre Thiery, Shamira Perera, Ching Lin Ho, Martin Buist, George Barbastathis, Tin Aung, Michaël J. A. Girard
Date: 2024-06-21 00:00:00

Objective. (1) To assess whether neural tissue structure and biomechanics could predict functional loss in glaucoma; (2) To evaluate the importance of biomechanics in making such predictions. Design, Setting and Participants. We recruited 238 glaucoma subjects. For one eye of each subject, we imaged the optic nerve head (ONH) using spectral-domain OCT under the following conditions: (1) primary gaze and (2) primary gaze with acute IOP elevation. Main Outcomes: We utilized automatic segmentation of optic nerve head (ONH) tissues and digital volume correlation (DVC) analysis to compute intraocular pressure (IOP)-induced neural tissue strains. A robust geometric deep learning approach, known as Point-Net, was employed to predict the full Humphrey 24-2 pattern standard deviation (PSD) maps from ONH structural and biomechanical information. For each point in each PSD map, we predicted whether it exhibited no defect or a PSD value of less than 5%. Predictive performance was evaluated using 5-fold cross-validation and the F1-score. We compared the model's performance with and without the inclusion of IOP-induced strains to assess the impact of biomechanics on prediction accuracy. Results: Integrating biomechanical (IOP-induced neural tissue strains) and structural (tissue morphology and neural tissues thickness) information yielded a significantly better predictive model (F1-score: 0.76+-0.02) across validation subjects, as opposed to relying only on structural information, which resulted in a significantly lower F1-score of 0.71+-0.02 (p < 0.05). Conclusion: Our study has shown that the integration of biomechanical data can significantly improve the accuracy of visual field loss predictions. This highlights the importance of the biomechanics-function relationship in glaucoma, and suggests that biomechanics may serve as a crucial indicator for the development and progression of glaucoma.
Do Large Language Models Exhibit Cognitive Dissonance? Studying the Difference Between Revealed Beliefs and Stated Answers
Authors: Manuel Mondal, Ljiljana Dolamic, Gérôme Bovet, Philippe Cudré-Mauroux, Julien Audiffren
Date: 2024-06-21 00:00:00

Prompting and Multiple Choices Questions (MCQ) have become the preferred approach to assess the capabilities of Large Language Models (LLMs), due to their ease of manipulation and evaluation. Such experimental appraisals have pointed toward the LLMs' apparent ability to perform causal reasoning or to grasp uncertainty. In this paper, we investigate whether these abilities are measurable outside of tailored prompting and MCQ by reformulating these issues as direct text completion - the foundation of LLMs. To achieve this goal, we define scenarios with multiple possible outcomes and we compare the prediction made by the LLM through prompting (their Stated Answer) to the probability distributions they compute over these outcomes during next token prediction (their Revealed Belief). Our findings suggest that the Revealed Belief of LLMs significantly differs from their Stated Answer and hint at multiple biases and misrepresentations that their beliefs may yield in many scenarios and outcomes. As text completion is at the core of LLMs, these results suggest that common evaluation methods may only provide a partial picture and that more research is needed to assess the extent and nature of their capabilities.
On the Worst Prompt Performance of Large Language Models
Authors: Bowen Cao, Deng Cai, Zhisong Zhang, Yuexian Zou, Wai Lam
Date: 2024-06-08 00:00:00
Tasks: Prompt Engineering

The performance of large language models (LLMs) is acutely sensitive to the phrasing of prompts, which raises significant concerns about their reliability in real-world scenarios. Existing studies often divide prompts into task-level instructions and case-level inputs and primarily focus on evaluating and improving robustness against variations in tasks-level instructions. However, this setup fails to fully address the diversity of real-world user queries and assumes the existence of task-specific datasets. To address these limitations, we introduce RobustAlpacaEval, a new benchmark that consists of semantically equivalent case-level queries and emphasizes the importance of using the worst prompt performance to gauge the lower bound of model performance. Extensive experiments on RobustAlpacaEval with ChatGPT and six open-source LLMs from the Llama, Mistral, and Gemma families uncover substantial variability in model performance; for instance, a difference of 45.48% between the worst and best performance for the Llama-2-70B-chat model, with its worst performance dipping as low as 9.38%. We further illustrate the difficulty in identifying the worst prompt from both model-agnostic and model-dependent perspectives, emphasizing the absence of a shortcut to characterize the worst prompt. We also attempt to enhance the worst prompt performance using existing prompt engineering and prompt consistency methods, but find that their impact is limited. These findings underscore the need to create more resilient LLMs that can maintain high performance across diverse prompts. Data and code are available at https://github.com/cbwbuaa/On-the-Worst-Prompt- Performance-of-LLMs.
Human-AI collectives produce the most accurate differential diagnoses
Authors: N. Zöller, J. Berger, I. Lin, N. Fu, J. Komarneni, G. Barabucci, K. Laskowski, V. Shia, B. Harack, E. A. Chu, V. Trianni, R. H. J. M. Kurvers, S. M. Herzog
Date: 2024-06-21 00:00:00
Tasks: Common Sense Reasoning

Artificial intelligence systems, particularly large language models (LLMs), are increasingly being employed in high-stakes decisions that impact both individuals and society at large, often without adequate safeguards to ensure safety, quality, and equity. Yet LLMs hallucinate, lack common sense, and are biased - shortcomings that may reflect LLMs' inherent limitations and thus may not be remedied by more sophisticated architectures, more data, or more human feedback. Relying solely on LLMs for complex, high-stakes decisions is therefore problematic. Here we present a hybrid collective intelligence system that mitigates these risks by leveraging the complementary strengths of human experience and the vast information processed by LLMs. We apply our method to open-ended medical diagnostics, combining 40,762 differential diagnoses made by physicians with the diagnoses of five state-of-the art LLMs across 2,133 medical cases. We show that hybrid collectives of physicians and LLMs outperform both single physicians and physician collectives, as well as single LLMs and LLM ensembles. This result holds across a range of medical specialties and professional experience, and can be attributed to humans' and LLMs' complementary contributions that lead to different kinds of errors. Our approach highlights the potential for collective human and machine intelligence to improve accuracy in complex, open-ended domains like medical diagnostics.
Trustworthy Enhanced Multi-view Multi-modal Alzheimer's Disease Prediction with Brain-wide Imaging Transcriptomics Data
Authors: Shan Cong, Zhoujie Fan, Hongwei Liu, Yinghan Zhang, Xin Wang, Haoran Luo, Xiaohui Yao
Date: 2024-06-21 00:00:00
Tasks: Disease Prediction, Graph Attention, Informativeness

Brain transcriptomics provides insights into the molecular mechanisms by which the brain coordinates its functions and processes. However, existing multimodal methods for predicting Alzheimer's disease (AD) primarily rely on imaging and sometimes genetic data, often neglecting the transcriptomic basis of brain. Furthermore, while striving to integrate complementary information between modalities, most studies overlook the informativeness disparities between modalities. Here, we propose TMM, a trusted multiview multimodal graph attention framework for AD diagnosis, using extensive brain-wide transcriptomics and imaging data. First, we construct view-specific brain regional co-function networks (RRIs) from transcriptomics and multimodal radiomics data to incorporate interaction information from both biomolecular and imaging perspectives. Next, we apply graph attention (GAT) processing to each RRI network to produce graph embeddings and employ cross-modal attention to fuse transcriptomics-derived embedding with each imagingderived embedding. Finally, a novel true-false-harmonized class probability (TFCP) strategy is designed to assess and adaptively adjust the prediction confidence of each modality for AD diagnosis. We evaluate TMM using the AHBA database with brain-wide transcriptomics data and the ADNI database with three imaging modalities (AV45-PET, FDG-PET, and VBM-MRI). The results demonstrate the superiority of our method in identifying AD, EMCI, and LMCI compared to state-of-the-arts. Code and data are available at https://github.com/Yaolab-fantastic/TMM.
Domain Adaptation of Llama3-70B-Instruct through Continual Pre-Training and Model Merging: A Comprehensive Evaluation
Authors: Shamane Siriwardhana, Mark McQuade, Thomas Gauthier, Lucas Atkins, Fernando Fernandes Neto, Luke Meyers, Anneketh Vij, Tyler Odenthal, Charles Goddard, Mary MacCarthy, Jacob Solawetz
Date: 2024-06-21 00:00:00
Tasks: Domain Adaptation, Language Modeling, Language Modelling

We conducted extensive experiments on domain adaptation of the Meta-Llama-3-70B-Instruct model on SEC data, exploring its performance on both general and domain-specific benchmarks. Our focus included continual pre-training (CPT) and model merging, aiming to enhance the model's domain-specific capabilities while mitigating catastrophic forgetting. Through this study, we evaluated the impact of integrating financial regulatory data into a robust language model and examined the effectiveness of our model merging techniques in preserving and improving the model's instructive abilities. The model is accessible at hugging face: https://huggingface.co/arcee-ai/Llama-3-SEC-Base, arcee-ai/Llama-3-SEC-Base. This is an intermediate checkpoint of our final model, which has seen 20B tokens so far. The full model is still in the process of training. This is a preprint technical report with thorough evaluations to understand the entire process.
Uni-Mol2: Exploring Molecular Pretraining Model at Scale
Authors: Xiaohong Ji, Zhen Wang, Zhifeng Gao, Hang Zheng, Linfeng Zhang, Guolin Ke, Weinan E
Date: 2024-06-21 00:00:00
Tasks: model

In recent years, pretraining models have made significant advancements in the fields of natural language processing (NLP), computer vision (CV), and life sciences. The significant advancements in NLP and CV are predominantly driven by the expansion of model parameters and data size, a phenomenon now recognized as the scaling laws. However, research exploring scaling law in molecular pretraining models remains unexplored. In this work, we present Uni-Mol2 , an innovative molecular pretraining model that leverages a two-track transformer to effectively integrate features at the atomic level, graph level, and geometry structure level. Along with this, we systematically investigate the scaling law within molecular pretraining models, characterizing the power-law correlations between validation loss and model size, dataset size, and computational resources. Consequently, we successfully scale Uni-Mol2 to 1.1 billion parameters through pretraining on 800 million conformations, making it the largest molecular pretraining model to date. Extensive experiments show consistent improvement in the downstream tasks as the model size grows. The Uni-Mol2 with 1.1B parameters also outperforms existing methods, achieving an average 27% improvement on the QM9 and 14% on COMPAS-1D dataset.
Deep Imbalanced Regression to Estimate Vascular Age from PPG Data: a Novel Digital Biomarker for Cardiovascular Health
Authors: Guangkun Nie, Qinghao Zhao, Gongzheng Tang, Jun Li, Shenda Hong
Date: 2024-06-21 00:00:00
Tasks: Deep imbalanced regression, Photoplethysmography (PPG)

Photoplethysmography (PPG) is emerging as a crucial tool for monitoring human hemodynamics, with recent studies highlighting its potential in assessing vascular aging through deep learning. However, real-world age distributions are often imbalanced, posing significant challenges for deep learning models. In this paper, we introduce a novel, simple, and effective loss function named the Dist Loss to address deep imbalanced regression tasks. We trained a one-dimensional convolutional neural network (Net1D) incorporating the Dist Loss on the extensive UK Biobank dataset (n=502,389) to estimate vascular age from PPG signals and validate its efficacy in characterizing cardiovascular health. The model's performance was validated on a 40% held-out test set, achieving state-of-the-art results, especially in regions with small sample sizes. Furthermore, we divided the population into three subgroups based on the difference between predicted vascular age and chronological age: less than -10 years, between -10 and 10 years, and greater than 10 years. We analyzed the relationship between predicted vascular age and several cardiovascular events over a follow-up period of up to 10 years, including death, coronary heart disease, and heart failure. Our results indicate that the predicted vascular age has significant potential to reflect an individual's cardiovascular health status. Our code will be available at https://github.com/Ngk03/AI-vascular-age.
An Idiosyncrasy of Time-discretization in Reinforcement Learning
Authors: Kris de Asis, Richard S. Sutton
Date: 2024-06-21 00:00:00
Tasks: reinforcement-learning, Reinforcement Learning

Many reinforcement learning algorithms are built on an assumption that an agent interacts with an environment over fixed-duration, discrete time steps. However, physical systems are continuous in time, requiring a choice of time-discretization granularity when digitally controlling them. Furthermore, such systems do not wait for decisions to be made before advancing the environment state, necessitating the study of how the choice of discretization may affect a reinforcement learning algorithm. In this work, we consider the relationship between the definitions of the continuous-time and discrete-time returns. Specifically, we acknowledge an idiosyncrasy with naively applying a discrete-time algorithm to a discretized continuous-time environment, and note how a simple modification can better align the return definitions. This observation is of practical consideration when dealing with environments where time-discretization granularity is a choice, or situations where such granularity is inherently stochastic.
CEASEFIRE: An AI-powered system for combatting illicit firearms trafficking
Authors: Jorgen Cani, Ioannis Mademlis, Marina Mancuso, Caterina Paternoster, Emmanouil Adamakis, George Margetis, Sylvie Chambon, Alain Crouzil, Loubna Lechelek, Georgia Dede, Spyridon Evangelatos, George Lalas, Franck Mignet, Pantelis Linardatos, Konstantinos Kentrotis, Henryk Gierszal, Piotr Tyczka, Sophia Karagiorgou, George Pantelis, Georgios Stavropoulos, Konstantinos Votis, Georgios Th. Papadopoulos
Date: 2024-06-21 00:00:00

Modern technologies have led illicit firearms trafficking to partially merge with cybercrime, while simultaneously permitting its off-line aspects to become more sophisticated. Law enforcement officers face difficult challenges that require hi-tech solutions. This article presents a real-world system, powered by advanced Artificial Intelligence, for facilitating them in their everyday work.
Towards Retrieval Augmented Generation over Large Video Libraries
Authors: Yannis Tevissen, Khalil Guetari, Frédéric Petitpont
Date: 2024-06-21 00:00:00
Tasks: Answer Generation, Question Answering, RAG, Retrieval, Retrieval-augmented Generation

Video content creators need efficient tools to repurpose content, a task that often requires complex manual or automated searches. Crafting a new video from large video libraries remains a challenge. In this paper we introduce the task of Video Library Question Answering (VLQA) through an interoperable architecture that applies Retrieval Augmented Generation (RAG) to video libraries. We propose a system that uses large language models (LLMs) to generate search queries, retrieving relevant video moments indexed by speech and visual metadata. An answer generation module then integrates user queries with this metadata to produce responses with specific video timestamps. This approach shows promise in multimedia content retrieval, and AI-assisted video content creation.
Autonomous Agents for Collaborative Task under Information Asymmetry
Authors: Wei Liu, Chenxi Wang, Yifei Wang, Zihao Xie, Rennai Qiu, Yufan Dang, Zhuoyun Du, Weize Chen, Cheng Yang, Chen Qian
Date: 2024-06-21 00:00:00
Tasks: Language Modelling, Large Language Model, Multi-agent Integration

Large Language Model Multi-Agent Systems (LLM-MAS) have achieved great progress in solving complex tasks. It performs communication among agents within the system to collaboratively solve tasks, under the premise of shared information. However, when agents' collaborations are leveraged to perform multi-person tasks, a new challenge arises due to information asymmetry, since each agent can only access the information of its human user. Previous MAS struggle to complete tasks under this condition. To address this, we propose a new MAS paradigm termed iAgents, which denotes Informative Multi-Agent Systems. In iAgents, the human social network is mirrored in the agent network, where agents proactively exchange human information necessary for task resolution, thereby overcoming information asymmetry. iAgents employs a novel agent reasoning mechanism, InfoNav, to navigate agents' communication toward effective information exchange. Together with InfoNav, iAgents organizes human information in a mixed memory to provide agents with accurate and comprehensive information for exchange. Additionally, we introduce InformativeBench, the first benchmark tailored for evaluating LLM agents' task-solving ability under information asymmetry. Experimental results show that iAgents can collaborate within a social network of 140 individuals and 588 relationships, autonomously communicate over 30 turns, and retrieve information from nearly 70,000 messages to complete tasks within 3 minutes.
Extraction of 3D trajectories of mandibular condyles from 2D real-time MRI
Authors: Karyna Isaieva, Justine Leclère, Guillaume Paillart, Guillaume Drouot, Jacques Felblinger, Xavier Dubernard, Pierre-André Vuissoz
Date: 2024-06-21 00:00:00

Computing the trajectories of mandibular condyles directly from MRI could provide a comprehensive examination, allowing for the extraction of both anatomical and kinematic details. This study aimed to investigate the feasibility of extracting 3D condylar trajectories from 2D real-time MRI and to assess their precision.Twenty healthy subjects underwent real-time MRI while opening and closing their jaws. One axial and two sagittal slices were segmented using a U-Net-based algorithm. The centers of mass of the resulting masks were projected onto the coordinate system based on anatomical markers and temporally adjusted using a common projection. The quality of the computed trajectories was evaluated using metrics designed to estimate movement reproducibility, head motion, and slice placement symmetry.The segmentation of the axial slices demonstrated good-to-excellent quality; however, the segmentation of the sagittal slices required some fine-tuning. The movement reproducibility was acceptable for most cases; nevertheless, head motion displaced the trajectories by 1 mm on average. The difference in the superior-inferior coordinate of the condyles in the closed jaw position was 1.7 mm on average.Despite limitations in precision, real-time MRI enables the extraction of condylar trajectories with sufficient accuracy for evaluating clinically relevant parameters such as condyle displacement, trajectories aspect, and symmetry.
LLM2FEA: Discover Novel Designs with Generative Evolutionary Multitasking
Authors: Melvin Wong, Jiao Liu, Thiago Rios, Stefan Menzel, Yew Soon Ong
Date: 2024-06-21 00:00:00
Tasks: Language Modelling, Large Language Model

The rapid research and development of generative artificial intelligence has enabled the generation of high-quality images, text, and 3D models from text prompts. This advancement impels an inquiry into whether these models can be leveraged to create digital artifacts for both creative and engineering applications. Drawing on innovative designs from other domains may be one answer to this question, much like the historical practice of ``bionics", where humans have sought inspiration from nature's exemplary designs. This raises the intriguing possibility of using generative models to simultaneously tackle design tasks across multiple domains, facilitating cross-domain learning and resulting in a series of innovative design solutions. In this paper, we propose LLM2FEA as the first attempt to discover novel designs in generative models by transferring knowledge across multiple domains. By utilizing a multi-factorial evolutionary algorithm (MFEA) to drive a large language model, LLM2FEA integrates knowledge from various fields to generate prompts that guide the generative model in discovering novel and practical objects. Experimental results in the context of 3D aerodynamic design verify the discovery capabilities of the proposed LLM2FEA. The designs generated by LLM2FEA not only satisfy practicality requirements to a certain degree but also feature novel and aesthetically pleasing shapes, demonstrating the potential applications of LLM2FEA in discovery tasks.
MoA: Mixture of Sparse Attention for Automatic Large Language Model Compression
Authors: Tianyu Fu, Haofeng Huang, Xuefei Ning, Genghan Zhang, Boju Chen, Tianqi Wu, Hongyi Wang, Zixiao Huang, Shiyao Li, Shengen Yan, Guohao Dai, Huazhong Yang, Yu Wang
Date: 2024-06-21 00:00:00
Tasks: GPU, Language Modeling, Language Modelling, Large Language Model, Long-Context Understanding, Model Compression

Sparse attention can effectively mitigate the significant memory and throughput demands of Large Language Models (LLMs) in long contexts. Existing methods typically employ a uniform sparse attention mask, applying the same sparse pattern across different attention heads and input lengths. However, this uniform approach fails to capture the diverse attention patterns inherent in LLMs, ignoring their distinct accuracy-latency trade-offs. To address this challenge, we propose the Mixture of Attention (MoA), which automatically tailors distinct sparse attention configurations to different heads and layers. MoA constructs and navigates a search space of various attention patterns and their scaling rules relative to input sequence lengths. It profiles the model, evaluates potential configurations, and pinpoints the optimal sparse attention compression plan. MoA adapts to varying input sizes, revealing that some attention heads expand their focus to accommodate longer sequences, while other heads consistently concentrate on fixed-length local contexts. Experiments show that MoA increases the effective context length by $3.9\times$ with the same average attention span, boosting retrieval accuracy by $1.5-7.1\times$ over the uniform-attention baseline across Vicuna-{7B,13B}, and Llama3-{8B,70B} models. Moreover, MoA narrows the capability gaps between sparse and dense models, reducing the maximum relative performance drop from $9\%-36\%$ to within $5\%$ across two long-context understanding benchmarks. MoA achieves a $1.2-1.4\times$ GPU memory reduction, boosting decode throughput by $6.6-8.2\times$ and $1.7-1.9\times$ compared to FlashAttention2 and vLLM, with minimal impact on performance. Our code is available at \url{https://github.com/thu-nics/MoA}.