pwc-archive/papers-with-abstracts huggingface dataset:
A Computational Approach to Epilepsy Treatment: An AI-optimized Global Natural Product Prescription System
Authors: Zhixuan Wang
Date: 2025-05-10 00:00:00
Tasks: Bayesian Optimization

Epilepsy is a prevalent neurological disease with millions of patients worldwide. Many patients have turned to alternative medicine due to the limited efficacy and side effects of conventional antiepileptic drugs. In this study, we developed a computational approach to optimize herbal epilepsy treatment through AI-driven analysis of global natural products and statistically validated randomized controlled trials (RCTs). Our intelligent prescription system combines machine learning (ML) algorithms for herb-efficacy characterization, Bayesian optimization for personalized dosing, and meta-analysis of RCTs for evidence-based recommendations. The system analyzed 1,872 natural compounds from traditional Chinese medicine (TCM), Ayurveda, and ethnopharmacological databases, integrating their bioactive properties with clinical outcomes from 48 RCTs covering 48 epilepsy conditions (n=5,216). Using LASSO regression and SHAP value analysis, we identified 17 high-efficacy herbs (e.g., Gastrodia elata [using \'e for accented characters], Withania somnifera), showing significant seizure reduction (p$<$0.01, Cohen's d=0.89) with statistical significance confirmed by multiple testing (p$<$0.001). A randomized double-blind validation trial (n=120) demonstrated 28.5\% greater seizure frequency reduction with AI-optimized herbal prescriptions compared to conventional protocols (95\% CI: 18.7-37.3\%, p=0.003).
Neurophysiologically Realistic Environment for Comparing Adaptive Deep Brain Stimulation Algorithms in Parkinson Disease
Authors: Ekaterina Kuzmina, Dmitrii Kriukov, Mikhail Lebedev, Dmitry V. Dylov
Date: 2025-04-26 00:00:00
Tasks: Deep Reinforcement Learning, Reinforcement Learning (RL)

Adaptive deep brain stimulation (aDBS) has emerged as a promising treatment for Parkinson disease (PD). In aDBS, a surgically placed electrode sends dynamically altered stimuli to the brain based on neurophysiological feedback: an invasive gadget that limits the amount of data one could collect for optimizing the control offline. As a consequence, a plethora of synthetic models of PD and those of the control algorithms have been proposed. Herein, we introduce the first neurophysiologically realistic benchmark for comparing said models. Specifically, our methodology covers not only conventional basal ganglia circuit dynamics and pathological oscillations, but also captures 15 previously dismissed physiological attributes, such as signal instabilities and noise, neural drift, electrode conductance changes and individual variability - all modeled as spatially distributed and temporally registered features via beta-band activity in the brain and a feedback. Furthermore, we purposely built our framework as a structured environment for training and evaluating deep reinforcement learning (RL) algorithms, opening new possibilities for optimizing aDBS control strategies and inviting the machine learning community to contribute to the emerging field of intelligent neurostimulation interfaces.
Artificial intelligence-enabled precision medicine for inflammatory skin diseases
Authors: Alice Tang, Maria Wei, Anna Haemel, Cindy La, Marina Sirota, Ernest Y. Lee
Date: 2025-05-14 00:00:00

Recent advances in artificial intelligence (AI) and multimodal data collection are revolutionizing dermatology. Generative AI and machine learning approaches offer opportunities to enhance the diagnosis and treatment of inflammatory skin diseases, including atopic dermatitis, psoriasis, hidradenitis suppurativa, and autoimmune connective tissue disease. This review examines the current landscape of AI applications for inflammatory skin diseases and explores how generative AI and machine learning methods can advance the field through deep phenotyping, disease heterogeneity characterization, drug development, personalized medicine, and clinical care. We discuss the promises and challenges of these technologies and present a vision for their integration into clinical practice.
Population dynamics of generalist/specialist strategies in the feast-famine cycle
Authors: Rintaro Niimi, Chikara Furusawa, Yusuke Himeoka
Date: 2025-05-15 00:00:00

Microbial populations exhibit a broad spectrum of nutrient utilization strategies, ranging from strategies utilizing diverse nutrients, called "generalist," to ones being highly adapted to specific nutrients, called "specialists." The mathematical conditions for the diversification of nutrient utilization strategies are central questions in theoretical ecology. Previous studies have shown that trade-offs among different resource utilization functions that cells cannot utilize broad types of substrates at near-maximum speed are crucial for the emergence of diverse strategies. However, in natural settings, nutrient availability often fluctuates over time, imposing additional trade-offs on cells. Cells that grow rapidly under nutrient-rich conditions will suffer a higher death rate under nutrient-poor conditions, creating a growth-death trade-off that intersects with the classical resource-use trade-off. Here, we introduce a unified mathematical model that simultaneously incorporates the resource-use trade-off and the growth-death trade-off. The nutrient supply was modeled as discrete stochastic events, capturing realistic temporal fluctuations. We show that the relative balance between growth and death rates critically influences the dominance of either generalist or specialist strategies. Specifically, under conditions of high average growth rates among different environments and a weak trade-off between growth and death rates, generalists prevail. In contrast, when the growth-death trade-off is intense, specialists emerge as the dominant strategy. Our findings reveal that accounting for the growth-death trade-off is crucial for understanding how microbial communities adapt and evolve in temporally varying environments.
Sequential Monte Carlo Squared for online inference in stochastic epidemic models
Authors: Dhorasso Temfack, Jason Wyse
Date: 2025-05-14 00:00:00
Tasks: Computational Efficiency

Effective epidemic modeling and surveillance require computationally efficient methods that can continuously update estimates as new data becomes available. This paper explores the application of an online variant of Sequential Monte Carlo Squared (O-SMC$^2$) to the stochastic Susceptible-Exposed-Infectious-Removed (SEIR) model for real-time epidemic tracking. The particularity of O-SMC$^2$ lies in its ability to update the parameters using a particle Metropolis-Hastings kernel, ensuring that the target distribution remains invariant while only utilizing a fixed window of recent observations. This feature enables timely parameter updates and significantly enhances computational efficiency compared to the standard SMC$^2$, which processes the entire dataset. First, we demonstrate the efficiency of O-SMC$^2$ on simulated data, where both the parameters and the observation process are known. We then apply the method to a real-world COVID-19 dataset from Ireland, successfully tracking the epidemic trajectory and estimating the time-dependent reproduction number of the disease. Our results show that O-SMC$^2$ provides highly accurate online estimates of both static and dynamic epidemiological parameters while substantially reducing computational costs. These findings highlight the potential of O-SMC$^2$ for real-time epidemic monitoring and supporting adaptive public health interventions.
A Tutorial on Structural Identifiability of Epidemic Models Using StructuralIdentifiability.jl
Authors: Yuganthi R. Liyanage, Omar Saucedo, Necibe Tuncer, Gerardo Chowell
Date: 2025-05-15 00:00:00
Tasks: parameter estimation

Structural identifiability -- the theoretical ability to uniquely recover model parameters from ideal, noise-free data -- is a prerequisite for reliable parameter estimation in epidemic modeling. Despite its importance, structural identifiability analysis remains underutilized in the infectious disease modeling literature. In this tutorial, we present a practical and reproducible workflow for conducting structural identifiability analysis of ordinary differential equation models using the Julia package StructuralIdentifiability.jl. We apply the tool to a range of epidemic models, including SEIR variants with asymptomatic and pre-symptomatic transmission, vector-borne systems, and models incorporating hospitalization and disease-induced mortality. We compare results from StructuralIdentifiability.jl with those obtained using DAISY, a widely used differential algebra tool, and highlight cases where the Julia package succeeds in analyzing models that DAISY cannot handle. In particular, StructuralIdentifiability.jl efficiently handles high-dimensional systems and provides symbolic checks for assumptions often overlooked in other methods. Our findings underscore how identifiability depends on model structure, the availability of initial conditions, and the choice of observed states. All code and diagrams are publicly available, making this tutorial a valuable reference for researchers and educators working with dynamic disease models.
Data mining of public genomic repositories: harnessing off-target reads to expand microbial pathogen genomic resources
Authors: Damien Richard, Nils Poulicard
Date: 2025-05-15 00:00:00

As sequencing technologies become more affordable and genomic databases expand continuously, the reuse of publicly available sequencing data emerges as a powerful strategy for studying microbial pathogens. Indeed, raw sequencing reads generated for the study of a given organism often contain reads originating from the associated microbiota. This review explores how such off-target reads can be detected and used for the study of microbial pathogens. We present genomic data mining as a method to identify relevant sequencing runs from petabase-scale databases, highlighting recent methodological advances that allow efficient database querying. We then briefly outline methods designed to retrieve relevant data and associated metadata, and provide an overview of common downstream analysis pipelines. We discuss how such approaches have (i) expanded the known genetic diversity of microbial pathogens, (ii) enriched our understanding of their spatiotemporal distribution, and (iii) highlighted previously unrecognized ecological interactions involving microbial pathogens. However, these analyses often rely on the completeness and accuracy of accompanying metadata, which remain highly variable. We detail common pitfalls, including data contamination and metadata misannotations, and suggest strategies for result interpretation. Ultimately, while data mining cannot replace dedicated studies, it constitutes an essential and complementary tool for microbial pathogen research. Broader utility will depend on improved data standardization and systematic genomic monitoring across ecosystems.
VIGIL: Vision-Language Guided Multiple Instance Learning Framework for Ulcerative Colitis Histological Healing Prediction
Authors: Zhengxuan Qiu, Bo Peng, Xiaoying Tang, Jiankun Wang, Qin Guo
Date: 2025-05-14 00:00:00
Tasks: Diagnostic, Multiple Instance Learning

Objective: Ulcerative colitis (UC), characterized by chronic inflammation with alternating remission-relapse cycles, requires precise histological healing (HH) evaluation to improve clinical outcomes. To overcome the limitations of annotation-intensive deep learning methods and suboptimal multi-instance learning (MIL) in HH prediction, we propose VIGIL, the first vision-language guided MIL framework integrating white light endoscopy (WLE) and endocytoscopy (EC). Methods:VIGIL begins with a dual-branch MIL module KS-MIL based on top-K typical frames selection and similarity metric adaptive learning to learn relationships among frame features effectively. By integrating the diagnostic report text and specially designed multi-level alignment and supervision between image-text pairs, VIGIL establishes joint image-text guidance during training to capture richer disease-related semantic information. Furthermore, VIGIL employs a multi-modal masked relation fusion (MMRF) strategy to uncover the latent diagnostic correlations of two endoscopic image representations. Results:Comprehensive experiments on a real-world clinical dataset demonstrate VIGIL's superior performance, achieving 92.69\% accuracy and 94.79\% AUC, outperforming existing state-of-the-art methods. Conclusion: The proposed VIGIL framework successfully establishes an effective vision-language guided MIL paradigm for UC HH prediction, reducing annotation burdens while improving prediction reliability. Significance: The research outcomes provide new insights for non-invasive UC diagnosis and hold theoretical significance and clinical value for advancing intelligent healthcare development.
Multimodal Modeling of Ultradian Rhythms Using the Hankel Alternative View of Koopman (HAVOK) Analysis
Authors: Emmanuel Molefi, Billy C. Smith, Christopher Thornton, Peter N. Taylor, Yujiang Wang
Date: 2025-05-13 00:00:00

Ultradian rhythms - quasi-rhythmic fluctuations in behavior and physiology with periods shorter than 24 hours - are observed across various organisms, including humans. Despite their role in key biological processes such as sleep architecture and hormone regulation, their underlying mechanisms remain poorly understood. Here, we leveraged wearable sensor technology for continuous monitoring of physiological signals in 16 healthy participants over two weeks. By systematically removing circadian and longer-scale rhythms, we isolated ultradian dynamics and modeled them using the Hankel Alternative View of Koopman (HAVOK) framework,a data-driven approach based on Takens' embedding theorem and Koopman operator theory. This allowed us to characterize ultradian rhythms as an intermittently forced linear system and distinguish between regular oscillatory behavior and more complex dynamics. Across participants, ultradian fluctuations were well-described by the HAVOK model, with intermittent forcing consistently observed. The model demonstrated strong forecasting accuracy, with root mean squared error (RMSE) of $0.0315 \pm 0.02$, $0.0306 \pm 0.02$, and $0.0218 \pm 0.02$ in the leading time-delay coordinates. Notably, a significant sex difference in model rank (z = -2.06, p = 0.0396) suggests that sex hormones may play a key role in ultradian dynamics. These findings provide evidence for intermittently forced linear systems as a useful framework for understanding ultradian rhythms and their regulation.
Fast Learning in Quantitative Finance with Extreme Learning Machine
Authors: Liexin Cheng, Xue Cheng, Shuaiqiang Liu
Date: 2025-05-14 00:00:00
Tasks: Computational Efficiency, regression

A critical factor in adopting machine learning for time-sensitive financial tasks is computational speed, including model training and inference. This paper demonstrates that a broad class of such problems, especially those previously addressed using deep neural networks, can be efficiently solved using single-layer neural networks without iterative gradient-based training. This is achieved through the extreme learning machine (ELM) framework. ELM utilizes a single-layer network with randomly initialized hidden nodes and output weights obtained via convex optimization, enabling rapid training and inference. We present various applications in both supervised and unsupervised learning settings, including option pricing, intraday return prediction, volatility surface fitting, and numerical solution of partial differential equations. Across these examples, ELM demonstrates notable improvements in computational efficiency while maintaining comparable accuracy and generalization compared to deep neural networks and classical machine learning methods. We also briefly discuss theoretical aspects of ELM implementation and its generalization capabilities.
FLUXLAYER: High-Performance Design for Cross-chain Fragmented Liquidity
Authors: Xin Lao, Shiping Chen, Qin Wang
Date: 2025-05-14 00:00:00

Autonomous Market Makers (AMMs) rely on arbitrage to facilitate passive price updates. Liquidity fragmentation poses a complex challenge across different blockchain networks. This paper proposes FluxLayer, a solution to mitigate fragmented liquidity and capture the maximum extractable value (MEV) in a cross-chain environment. FluxLayer is a three-layer framework that integrates a settlement layer, an intent layer, and an under-collateralised leverage lending vault mechanism. Our evaluation demonstrates that FluxLayer can effectively enhance cross-chain MEV by capturing more arbitrage opportunities, reducing costs, and improving overall liquidity.
Choices or constraints: decoding financial empowerment among women entrepreneurs in France
Authors: Jonathan Labbé, Typhaine Lebègue, Abdel Malik Ola
Date: 2025-05-15 00:00:00
Tasks: Diversity

This research examines the empowerment of women entrepreneurs in the context of entrepreneurial financing in France. It explores the factors that allow some women entrepreneurs to access certain categories of external finance more easily. The theoretical framework used is based on the concept of empowerment, explored through its personal and relational dimensions. The study relies on a quantitative approach, using data from a representative of women entrepreneurs. The results show that the status of a founder affects access to external finance in different ways: it increases the chances of successful fundraising, but reduces the chances of obtaining bank finance. This finding highlights the importance of empowerment dynamics, which vary according to the type of financing. In addition, characteristics such as the presence of a spouse in the business, high income, membership of a professional network and the diversity of this network complete the analysis of inequalities in access. This study, the first of its kind in France, suggests ways of enriching our understanding of the diversity of situations experienced by female founders, thus helping to deconstruct the homogeneous image of women's entrepreneurship.
The value of partial information
Authors: Philip A. Ernst, Oleksii Mostovyi
Date: 2025-05-13 00:00:00

We investigate a pricing rule that is applicable for streams of income or contingent claim liabilities and study how this rule changes under additional insider-type information that an investor might obtain. Considering a model where the risky asset might have jumps, we obtain an explicit form of the associated state price density for the three different types of agents considered in [ER20]: one who has no information about the jumps, one who knows in advance exactly when the each jump will occur, and one who has no information about the size of the jumps but has partial information about the size of each jump. For each of these agents, we provide characterizations of the pricing rule and establish a representation formula, allowing us to quantify the value of partial information for streams of labor income or contingent claim liabilities. Our work is motivated by finding and characterizing a pricing rule that, both with or without partial information about jumps, assigns different values of information for different income streams or contingent claim liabilities.
Mechanisms of information communication and market price movements. The case of SP 500 market
Authors: Inga Ivanova, Grzegorz Rzadkowski
Date: 2025-04-28 00:00:00

In this paper we analyze how market prices change in response to information processing among the market participants and how non-linear information dynamics drive market price movement. We analyze historical data of the SP 500 market for the period 1950 -2025 using the logistic Continuous Wavelet Transformation method. This approach allows us to identify various patterns in market dynamics. These patterns are conceptualized using a new theory of reflexive communication of information in a market consisting of heterogeneous agents who assign meaning to information from different perspectives. This allows us to describe market dynamics and make forecasts of its development using the most general mechanisms of information circulation within the content-free approach.
The impact of economic policies on housing prices. Approximations and predictions in the UK, the US, France, and Switzerland from the 1980s to today
Authors: Nicolas Houlié
Date: 2025-04-10 00:00:00

I show that house prices can be modeled using machine learning (kNN and tree-bagging) and a small dataset composed of macro-economic factors (MEF), including an inflation metric (CPI), US treasury rates (10-yr), Gross Domestic Product (GDP), and portfolio size of central banks (ECB, FED). This set of parameters covers all the parties involved in a transaction (buyer, seller, and financing facility) while ignoring the intrinsic properties of each asset and encompassing local (inflation) and liquidity issues that may impede each transaction composing a market. The model here takes the point of view of a real estate trader who is interested in both the financing and the price of the transaction. Machine Learning allows for the discrimination of two periods within the dataset. Unconventional policies of central banks may have allowed some institutional investors to arbitrage between real estate returns and other bond markets (sovereign and corporate). Finally, to assess the models' relative performances, I performed various sensitivity tests, which tend to constrain the possibilities of each approach for each need. I also show that some models can predict the evolution of prices over the next 4 quarters with uncertainties that outperform existing index uncertainties.
Machine Learning Solutions Integrated in an IoT Healthcare Platform for Heart Failure Risk Stratification
Authors: Pietro Cassieri, Aiman Faiz, Anna Maria De Roberto, Claudio Pascarelli, Gianvito Mitrano, Gianluca Fimiani, Marina Garofano, Genoveffa Tortora, Mariangela Lazoi, Claudio Passino, Alessia Bramanti, Giuseppe Scanniello
Date: 2025-04-07 00:00:00
Tasks: Ensemble Learning, Management

The management of chronic Heart Failure (HF) presents significant challenges in modern healthcare, requiring continuous monitoring, early detection of exacerbations, and personalized treatment strategies. In this paper, we present a predictive model founded on Machine Learning (ML) techniques to identify patients at HF risk. This model is an ensemble learning approach, a modified stacking technique, that uses two specialized models leveraging clinical and echocardiographic features and then a meta-model to combine the predictions of these two models. We initially assess the model on a real dataset and the obtained results suggest that it performs well in the stratification of patients at HR risk. Specifically, we obtained high sensitivity (95\%), ensuring that nearly all high-risk patients are identified. As for accuracy, we obtained 84\%, which can be considered moderate in some ML contexts. However, it is acceptable given our priority of identifying patients at risk of HF because they will be asked to participate in the telemonitoring program of the PrediHealth research project on which some of the authors of this paper are working. The initial findings also suggest that ML-based risk stratification models can serve as valuable decision-support tools not only in the PrediHealth project but also for healthcare professionals, aiding in early intervention and personalized patient management. To have a better understanding of the value and of potentiality of our predictive model, we also contrasted its results with those obtained by using three baseline models. The preliminary results indicate that our predictive model outperforms these baselines that flatly consider features, \ie not grouping them in clinical and echocardiographic features.