Analysis of the MICCAI Brain Tumor Segmentation -- Metastases (BraTS-METS) 2025 Lighthouse Challenge: Brain Metastasis Segmentation on Pre- and Post-treatment MRI
Authors: Nazanin Maleki, Raisa Amiruddin, Ahmed W. Moawad, Nikolay Yordanov, Athanasios Gkampenis, Pascal Fehringer, Fabian Umeh, Crystal Chukwurah, Fatima Memon, Bojan Petrovic, Justin Cramer, Mark Krycia, Elizabeth B. Shrickel, Ichiro Ikuta, Gerard Thompson, Lorenna Vidal, Vilma Kosovic, Adam E. Goldman-Yassen, Virginia Hill, Tiffany So, Sedra Mhana, Albara Alotaibi, Nathan Page, Prisha Bhatia, Marko Jakovljevic, Salma Abosabie, Sara Abosabie, Mohanad Ghonim, Mohamed Ghonim, Amirreza Manteghinejad, Anastasia Janas, Kiril Krantchev, Maruf Adewole, Jake Albrecht, Udunna Anazodo, Sanjay Aneja, Syed Muhammad Anwar, Timothy Bergquist, Veronica Chiang, Verena Chung, Gian Marco Conte, Farouk Dako, James Eddy, Ivan Ezhov, Nastaran Khalili, Keyvan Farahani, Juan Eugenio Iglesias, Zhifan Jiang, Elaine Johanson, Anahita Fathi Kazerooni, Florian Kofler, Dominic LaBella, Koen van Leemput, Hongwei Bran Li, Marius George Linguraru, Xinyang Liu, Zeke Meier, Bjoern H Menze, Harrison Moy, Klara Osenberg, Marie Piraud, Zachary Reitman, Russell Takeshi Shinohara, Chunhao Wang, Benedikt Wiestler, Walter Wiggins, Umber Shafique, Klara Willms, Arman Avesta, Khaled Bousabarah, Satrajit Chakrabarty, Nicolo Gennaro, Wolfgang Holler, Manpreet Kaur, Pamela Lamontagne, MingDe Lin, Jan Lost, Daniel S. Marcus, Ryan Maresca, Sarah Merkaj, Gabriel Cassinelli Pedersen, Marc von Reppert, Aristeidis Sotiras, Oleg Teytelboym, Niklas Tillmans, Malte Westerhoff, Ayda Youssef, Devon Godfrey, Scott Floyd, Andreas Rauschecker, Javier Villanueva-Meyer, Irada Pflüger, Jaeyoung Cho, Martin Bendszus, Gianluca Brugnara, Gloria J. Guzman Perez-Carillo, Derek R. Johnson, Anthony Kam, Benjamin Yin Ming Kwan, Lillian Lai, Neil U. Lall, Satya Narayana Patro, Lei Wu, Anu Bansal, Frederik Barkhof, Cristina Besada, Sammy Chu, Jason Druzgal, Alexandru Dusoi, Luciano Farage, Fabricio Feltrin, Amy Fong, Steve H. Fung, R. Ian Gray, Michael Iv, Alida A. Postma, Amit Mahajan, David Joyner, Chase Krumpelman, Laurent Letourneau-Guillon, Christie M. Lincoln, Mate E. Maros, Elka Miller, Fanny Morón, Esther A. Nimchinsky, Ozkan Ozsarlak, Uresh Patel, Saurabh Rohatgi, Atin Saha, Anousheh Sayah, Eric D. Schwartz, Robert Shih, Mark S. Shiroishi, Juan E. Small, Manoj Tanwar, Jewels Valerie, Brent D. Weinberg, Matthew L. White, Robert Young, Vahe M. Zohrabian, Aynur Azizova, Melanie Maria Theresa Brüßeler, Abdullah Okar, Luca Pasquini, Yasaman Sharifi, Gagandeep Singh, Nico Sollmann, Theodora Soumala, Mahsa Taherzadeh, Philipp Vollmuth, Martha Foltyn-Dumitru, Ajay Malhotra, Francesco Dellepiane, Víctor M. Pérez-García, Hesham Elhalawani, Maria Correia de Verdier, Sanaria Al Rubaiey, Rui Duarte Armindo, Kholod Ashraf, Moamen M. Asla, Mohamed Badawy, Jeroen Bisschop, Nima Broomand Lomer, Jan Bukatz, Jim Chen, Petra Cimflova, Felix Corr, Alexis Crawley, Lisa Deptula, Tasneem Elakhdar, Islam H. Shawali, Shahriar Faghani, Alexandra Frick, Vaibhav Gulati, Muhammad Ammar Haider, Fátima Hierro, Rasmus Holmboe Dahl, Sarah Maria Jacobs, Kuang-chun Jim Hsieh, Sedat G. Kandemirli, Katharina Kersting, Laura Kida, Sofia Kollia, Ioannis Koukoulithras, Xiao Li, Ahmed Abouelatta, Aya Mansour, Ruxandra-Catrinel Maria-Zamfirescu, Marcela Marsiglia, Yohana Sarahi Mateo-Camacho, Mark McArthur, Olivia McDonnel, Maire McHugh, Mana Moassefi, Samah Mostafa Morsi, Alexander Munteanu, Khanak K. Nandolia, Syed Raza Naqvi, Yalda Nikanpour, Mostafa Alnoury, Abdullah Mohamed Aly Nouh, Francesca Pappafava, Markand D. Patel, Samantha Petrucci, Eric Rawie, Scott Raymond, Borna Roohani, Sadeq Sabouhi, Laura M. Sanchez Garcia, Zoe Shaked, Pokhraj P. Suthar, Talissa Altes, Edvin Isufi, Yaseen Dhemesh, Jaime Gass, Jonathan Thacker, Abdul Rahman Tarabishy, Benjamin Turner, Sebastiano Vacca, George K. Vilanilam, Daniel Warren, David Weiss, Fikadu Worede, Sara Yousry, Wondwossen Lerebo, Alejandro Aristizabal, Alexandros Karargyris, Hasan Kassem, Sarthak Pati, Micah Sheller, Katherine E. Link, Evan Calabrese, Nourel Hoda Tahon, Ayman Nada, Jeffrey D. Rudie, Janet Reid, Kassa Darge, Aly H. Abayazeed, Philipp Lohmann, Yuri S. Velichko, Spyridon Bakas, Mariam Aboian
Date: 2025-04-16 00:00:00
Tasks: Brain Tumor Segmentation, Prognosis, Segmentation, Tumor Segmentation

Despite continuous advancements in cancer treatment, brain metastatic disease remains a significant complication of primary cancer and is associated with an unfavorable prognosis. One approach for improving diagnosis, management, and outcomes is to implement algorithms based on artificial intelligence for the automated segmentation of both pre- and post-treatment MRI brain images. Such algorithms rely on volumetric criteria for lesion identification and treatment response assessment, which are still not available in clinical practice. Therefore, it is critical to establish tools for rapid volumetric segmentations methods that can be translated to clinical practice and that are trained on high quality annotated data. The BraTS-METS 2025 Lighthouse Challenge aims to address this critical need by establishing inter-rater and intra-rater variability in dataset annotation by generating high quality annotated datasets from four individual instances of segmentation by neuroradiologists while being recorded on video (two instances doing "from scratch" and two instances after AI pre-segmentation). This high-quality annotated dataset will be used for testing phase in 2025 Lighthouse challenge and will be publicly released at the completion of the challenge. The 2025 Lighthouse challenge will also release the 2023 and 2024 segmented datasets that were annotated using an established pipeline of pre-segmentation, student annotation, two neuroradiologists checking, and one neuroradiologist finalizing the process. It builds upon its previous edition by including post-treatment cases in the dataset. Using these high-quality annotated datasets, the 2025 Lighthouse challenge plans to test benchmark algorithms for automated segmentation of pre-and post-treatment brain metastases (BM), trained on diverse and multi-institutional datasets of MRI images obtained from patients with brain metastases.