pwc-archive/papers-with-abstracts huggingface dataset:
UNet-3D with Adaptive TverskyCE Loss for Pancreas Medical Image Segmentation
Authors: Xubei Zhang, Mikhail Y. Shalaginov, Tingying Helen Zeng
Date: 2025-05-04 00:00:00
Tasks: Computed Tomography (CT), Image Segmentation, Medical Image Segmentation, Pancreas Segmentation, Segmentation, Semantic Segmentation

Pancreatic cancer, which has a low survival rate, is the most intractable one among all cancers. Most diagnoses of this cancer heavily depend on abdominal computed tomography (CT) scans. Therefore, pancreas segmentation is crucial but challenging. Because of the obscure position of the pancreas, surrounded by other large organs, and its small area, the pancreas has often been impeded and difficult to detect. With these challenges , the segmentation results based on Deep Learning (DL) models still need to be improved. In this research, we propose a novel adaptive TverskyCE loss for DL model training, which combines Tversky loss with cross-entropy loss using learnable weights. Our method enables the model to adjust the loss contribution automatically and find the best objective function during training. All experiments were conducted on the National Institutes of Health (NIH) Pancreas-CT dataset. We evaluated the adaptive TverskyCE loss on the UNet-3D and Dilated UNet-3D, and our method achieved a Dice Similarity Coefficient (DSC) of 85.59%, with peak performance up to 95.24%, and the score of 85.14%. DSC and the score were improved by 9.47% and 8.98% respectively compared with the baseline UNet-3D with Tversky loss for pancreas segmentation. Keywords: Pancreas segmentation, Tversky loss, Cross-entropy loss, UNet-3D, Dilated UNet-3D
Rethinking RGB-Event Semantic Segmentation with a Novel Bidirectional Motion-enhanced Event Representation
Authors: Zhen Yao, Xiaowen Ying, Mooi Choo Chuah
Date: 2025-05-02 00:00:00
Tasks: Semantic Segmentation

Event cameras capture motion dynamics, offering a unique modality with great potential in various computer vision tasks. However, RGB-Event fusion faces three intrinsic misalignments: (i) temporal, (ii) spatial, and (iii) modal misalignment. Existing voxel grid representations neglect temporal correlations between consecutive event windows, and their formulation with simple accumulation of asynchronous and sparse events is incompatible with the synchronous and dense nature of RGB modality. To tackle these challenges, we propose a novel event representation, Motion-enhanced Event Tensor (MET), which transforms sparse event voxels into a dense and temporally coherent form by leveraging dense optical flows and event temporal features. In addition, we introduce a Frequency-aware Bidirectional Flow Aggregation Module (BFAM) and a Temporal Fusion Module (TFM). BFAM leverages the frequency domain and MET to mitigate modal misalignment, while bidirectional flow aggregation and temporal fusion mechanisms resolve spatiotemporal misalignment. Experimental results on two large-scale datasets demonstrate that our framework significantly outperforms state-of-the-art RGB-Event semantic segmentation approaches. Our code is available at: https://github.com/zyaocoder/BRENet.
No Other Representation Component Is Needed: Diffusion Transformers Can Provide Representation Guidance by Themselves
Authors: Dengyang Jiang, Mengmeng Wang, Liuzhuozheng Li, Lei Zhang, Haoyu Wang, Wei Wei, Guang Dai, Yanning Zhang, Jingdong Wang
Date: 2025-05-05 00:00:00
Tasks: Image Generation, Representation Learning

Recent studies have demonstrated that learning a meaningful internal representation can both accelerate generative training and enhance the generation quality of diffusion transformers. However, existing approaches necessitate to either introduce an external and complex representation training framework or rely on a large-scale, pre-trained representation foundation model to provide representation guidance during the original generative training process. In this study, we posit that the unique discriminative process inherent to diffusion transformers enables them to offer such guidance without requiring external representation components. We therefore propose Self-Representation Alignment (SRA), a simple yet straightforward method that obtains representation guidance through a self-distillation manner. Specifically, SRA aligns the output latent representation of the diffusion transformer in the earlier layer with higher noise to that in the later layer with lower noise to progressively enhance the overall representation learning during only the generative training process. Experimental results indicate that applying SRA to DiTs and SiTs yields consistent performance improvements. Moreover, SRA not only significantly outperforms approaches relying on auxiliary, complex representation training frameworks but also achieves performance comparable to methods that are heavily dependent on powerful external representation priors.
LensNet: An End-to-End Learning Framework for Empirical Point Spread Function Modeling and Lensless Imaging Reconstruction
Authors: Jiesong Bai, Yuhao Yin, Yihang Dong, Xiaofeng Zhang, Chi-Man Pun, Xuhang Chen
Date: 2025-05-03 00:00:00

Lensless imaging stands out as a promising alternative to conventional lens-based systems, particularly in scenarios demanding ultracompact form factors and cost-effective architectures. However, such systems are fundamentally governed by the Point Spread Function (PSF), which dictates how a point source contributes to the final captured signal. Traditional lensless techniques often require explicit calibrations and extensive pre-processing, relying on static or approximate PSF models. These rigid strategies can result in limited adaptability to real-world challenges, including noise, system imperfections, and dynamic scene variations, thus impeding high-fidelity reconstruction. In this paper, we propose LensNet, an end-to-end deep learning framework that integrates spatial-domain and frequency-domain representations in a unified pipeline. Central to our approach is a learnable Coded Mask Simulator (CMS) that enables dynamic, data-driven estimation of the PSF during training, effectively mitigating the shortcomings of fixed or sparsely calibrated kernels. By embedding a Wiener filtering component, LensNet refines global structure and restores fine-scale details, thus alleviating the dependency on multiple handcrafted pre-processing steps. Extensive experiments demonstrate LensNet's robust performance and superior reconstruction quality compared to state-of-the-art methods, particularly in preserving high-frequency details and attenuating noise. The proposed framework establishes a novel convergence between physics-based modeling and data-driven learning, paving the way for more accurate, flexible, and practical lensless imaging solutions for applications ranging from miniature sensors to medical diagnostics. The link of code is https://github.com/baijiesong/Lensnet.
GraphATC: advancing multilevel and multi-label anatomical therapeutic chemical classification via atom-level graph learning
Authors: WengYu Zhang, Qi Tian, Yi Cao, Wenqi Fan, Dongmei Jiang, YaoWei Wang, Qing Li, Xiao-Yong Wei
Date: 2025-04-26 00:00:00
Proceeding: Briefings in Bioinformatics 2025 4
Tasks: Drug ATC Classification, Graph Classification, Graph Learning, Molecular Property Prediction, Multi-Label Classification, MUlTI-LABEL-ClASSIFICATION

The accurate categorization of compounds within the anatomical therapeutic chemical (ATC) system is fundamental for drug development and fundamental research. Although this area has garnered significant research focus for over a decade, the majority of prior studies have concentrated solely on the Level 1 labels defined by the World Health Organization (WHO), neglecting the labels of the remaining four levels. This narrow focus fails to address the true nature of the task as a multilevel, multi-label classification challenge. Moreover, existing benchmarks like Chen-2012 and ATC-SMILES have become outdated, lacking the incorporation of new drugs or updated properties of existing ones that have emerged in recent years and have been integrated into the WHO ATC system. To tackle these shortcomings, we present a comprehensive approach in this paper. Firstly, we systematically cleanse and enhance the drug dataset, expanding it to encompass all five levels through a rigorous cross-resource validation process involving KEGG, PubChem, ChEMBL, ChemSpider, and ChemicalBook. This effort culminates in the creation of a novel benchmark termed ATC-GRAPH. Secondly, we extend the classification task to encompass Level 2 and introduce graph-based learning techniques to provide more accurate representations of drug molecular structures. This approach not only facilitates the modeling of Polymers, Macromolecules, and Multi-Component drugs more precisely but also enhances the overall fidelity of the classification process. The efficacy of our proposed framework is validated through extensive experiments, establishing a new state-of-the-art methodology. To facilitate the replication of this study, we have made the benchmark dataset, source code, and web server openly accessible (https://github.com/lookwei/GraphATC).
Identifying the kind behind SMILES—anatomical therapeutic chemical classification using structure-only representations
Authors: Yi Cao, Zhen-Qun Yang, Xu-Lu Zhang, Wenqi Fan, YaoWei Wang, Jiajun Shen, Dong-Qing Wei, Qing Li, Xiao-Yong Wei
Date: 2022-08-26 00:00:00
Proceeding: Briefings in Bioinformatics 2022 8
Tasks: Drug ATC Classification, Molecular Property Prediction

Anatomical Therapeutic Chemical (ATC) classification for compounds/drugs plays an important role in drug development and basic research. However, previous methods depend on interactions extracted from STITCH dataset which may make it depend on lab experiments. We present a pilot study to explore the possibility of conducting the ATC prediction solely based on the molecular structures. The motivation is to eliminate the reliance on the costly lab experiments so that the characteristics of a drug can be pre-assessed for better decision-making and effort-saving before the actual development. To this end, we construct a new benchmark consisting of 4545 compounds which is with larger scale than the one used in previous study. A light-weight prediction model is proposed. The model is with better explainability in the sense that it is consists of a straightforward tokenization that extracts and embeds statistically and physicochemically meaningful tokens, and a deep network backed by a set of pyramid kernels to capture multi-resolution chemical structural characteristics. Its efficacy has been validated in the experiments where it outperforms the state-of-the-art methods by 15.53% in accuracy and by 69.66% in terms of efficiency. We make the benchmark dataset, source code and web server open to ease the reproduction of this study.
DPNet: Dynamic Pooling Network for Tiny Object Detection
Authors: Luqi Gong, Haotian Chen, Yikun Chen, Tianliang Yao, Chao Li, Shuai Zhao, Guangjie Han
Date: 2025-05-05 00:00:00
Tasks: object-detection, Object Detection

In unmanned aerial systems, especially in complex environments, accurately detecting tiny objects is crucial. Resizing images is a common strategy to improve detection accuracy, particularly for small objects. However, simply enlarging images significantly increases computational costs and the number of negative samples, severely degrading detection performance and limiting its applicability. This paper proposes a Dynamic Pooling Network (DPNet) for tiny object detection to mitigate these issues. DPNet employs a flexible down-sampling strategy by introducing a factor (df) to relax the fixed downsampling process of the feature map to an adjustable one. Furthermore, we design a lightweight predictor to predict df for each input image, which is used to decrease the resolution of feature maps in the backbone. Thus, we achieve input-aware downsampling. We also design an Adaptive Normalization Module (ANM) to make a unified detector compatible with different dfs. A guidance loss supervises the predictor's training. DPNet dynamically allocates computing resources to trade off between detection accuracy and efficiency. Experiments on the TinyCOCO and TinyPerson datasets show that DPNet can save over 35% and 25% GFLOPs, respectively, while maintaining comparable detection performance. The code will be made publicly available.
Deterministic-to-Stochastic Diverse Latent Feature Mapping for Human Motion Synthesis
Authors: Yu Hua, Weiming Liu, Gui Xu, Yaqing Hou, Yew-Soon Ong, Qiang Zhang
Date: 2025-05-02 00:00:00
Proceeding: CVPR 2025 1
Tasks: Diversity, Motion Generation, Motion Synthesis

Human motion synthesis aims to generate plausible human motion sequences, which has raised widespread attention in computer animation. Recent score-based generative models (SGMs) have demonstrated impressive results on this task. However, their training process involves complex curvature trajectories, leading to unstable training process. In this paper, we propose a Deterministic-to-Stochastic Diverse Latent Feature Mapping (DSDFM) method for human motion synthesis. DSDFM consists of two stages. The first human motion reconstruction stage aims to learn the latent space distribution of human motions. The second diverse motion generation stage aims to build connections between the Gaussian distribution and the latent space distribution of human motions, thereby enhancing the diversity and accuracy of the generated human motions. This stage is achieved by the designed deterministic feature mapping procedure with DerODE and stochastic diverse output generation procedure with DivSDE.DSDFM is easy to train compared to previous SGMs-based methods and can enhance diversity without introducing additional training parameters.Through qualitative and quantitative experiments, DSDFM achieves state-of-the-art results surpassing the latest methods, validating its superiority in human motion synthesis.
On the Mechanistic Interpretability of Neural Networks for Causality in Bio-statistics
Authors: Jean-Baptiste A. Conan
Date: 2025-05-01 00:00:00
Tasks: Causal Inference

Interpretable insights from predictive models remain critical in bio-statistics, particularly when assessing causality, where classical statistical and machine learning methods often provide inherent clarity. While Neural Networks (NNs) offer powerful capabilities for modeling complex biological data, their traditional "black-box" nature presents challenges for validation and trust in high-stakes health applications. Recent advances in Mechanistic Interpretability (MI) aim to decipher the internal computations learned by these networks. This work investigates the application of MI techniques to NNs within the context of causal inference for bio-statistics. We demonstrate that MI tools can be leveraged to: (1) probe and validate the internal representations learned by NNs, such as those estimating nuisance functions in frameworks like Targeted Minimum Loss-based Estimation (TMLE); (2) discover and visualize the distinct computational pathways employed by the network to process different types of inputs, potentially revealing how confounders and treatments are handled; and (3) provide methodologies for comparing the learned mechanisms and extracted insights across statistical, machine learning, and NN models, fostering a deeper understanding of their respective strengths and weaknesses for causal bio-statistical analysis.
MPEC: Manifold-Preserved EEG Classification via an Ensemble of Clustering-Based Classifiers
Authors: Shermin Shahbazi, Mohammad-Reza Nasiri, Majid Ramezani
Date: 2025-04-30 00:00:00
Tasks: Classification, Clustering, EEG, Feature Engineering

Accurate classification of EEG signals is crucial for brain-computer interfaces (BCIs) and neuroprosthetic applications, yet many existing methods fail to account for the non-Euclidean, manifold structure of EEG data, resulting in suboptimal performance. Preserving this manifold information is essential to capture the true geometry of EEG signals, but traditional classification techniques largely overlook this need. To this end, we propose MPEC (Manifold-Preserved EEG Classification via an Ensemble of Clustering-Based Classifiers), that introduces two key innovations: (1) a feature engineering phase that combines covariance matrices and Radial Basis Function (RBF) kernels to capture both linear and non-linear relationships among EEG channels, and (2) a clustering phase that employs a modified K-means algorithm tailored for the Riemannian manifold space, ensuring local geometric sensitivity. Ensembling multiple clustering-based classifiers, MPEC achieves superior results, validated by significant improvements on the BCI Competition IV dataset 2a.
Knowledge Graphs for Enhancing Large Language Models in Entity Disambiguation
Authors: Gerard Pons, Besim Bilalli, Anna Queralt
Date: 2025-05-05 00:00:00
Tasks: Entity Disambiguation, Hallucination, Knowledge Graphs

Recent advances in Large Language Models (LLMs) have positioned them as a prominent solution for Natural Language Processing tasks. Notably, they can approach these problems in a zero or few-shot manner, thereby eliminating the need for training or fine-tuning task-specific models. However, LLMs face some challenges, including hallucination and the presence of outdated knowledge or missing information from specific domains in the training data. These problems cannot be easily solved by retraining the models with new data as it is a time-consuming and expensive process. To mitigate these issues, Knowledge Graphs (KGs) have been proposed as a structured external source of information to enrich LLMs. With this idea, in this work we use KGs to enhance LLMs for zero-shot Entity Disambiguation (ED). For that purpose, we leverage the hierarchical representation of the entities' classes in a KG to gradually prune the candidate space as well as the entities' descriptions to enrich the input prompt with additional factual knowledge. Our evaluation on popular ED datasets shows that the proposed method outperforms non-enhanced and description-only enhanced LLMs, and has a higher degree of adaptability than task-specific models. Furthermore, we conduct an error analysis and discuss the impact of the leveraged KG's semantic expressivity on the ED performance.
Enhancing Black-Litterman Portfolio via Hybrid Forecasting Model Combining Multivariate Decomposition and Noise Reduction
Authors: Ziye Yang, Ke Lu, Yang Wang, Jerome Yen
Date: 2025-05-03 00:00:00
Tasks: Denoising

Modern portfolio construction demands robust methods for integrating data-driven insights into asset allocation. The Black-Litterman model offers a powerful Bayesian approach to adjust equilibrium returns using investor views to form a posterior expectation along with market priors. Mainstream research mainly generates subjective views through statistical models or machine learning methods, among which hybrid models combined with decomposition algorithms perform well. However, most hybrid models do not pay enough attention to noise, and time series decomposition methods based on single variables make it difficult to fully utilize information between multiple variables. Multivariate decomposition also has problems of low efficiency and poor component quality. In this study, we propose a novel hybrid forecasting model SSA-MAEMD-TCN to automate and improve the view generation process. The proposed model combines Singular Spectrum Analysis (SSA) for denoising, Multivariate Aligned Empirical Mode Decomposition (MA-EMD) for frequency-aligned decomposition, and Temporal Convolutional Networks (TCNs) for deep sequence learning to capture complex temporal patterns across multiple financial indicators. Empirical tests on the Nasdaq 100 Index stocks show a significant improvement in forecasting performance compared to baseline models based on MAEMD and MEMD. The optimized portfolio performs well, with annualized returns and Sharpe ratios far exceeding those of the traditional portfolio over a short holding period, even after accounting for transaction costs.
Assessing the Feasibility of Internet-Sourced Video for Automatic Cattle Lameness Detection
Authors: Md Fahimuzzman Sohan, A. H. Abdul Hafez, Raid Alzubi
Date: 2025-04-23 00:00:00
Tasks: Data Augmentation, Deep Learning, object-detection, Object Detection, Pose Estimation

Cattle lameness is often caused by hoof injuries or interdigital dermatitis, leads to pain and significantly impacts essential physiological activities such as walking, feeding, and drinking. This study presents a deep learning-based model for detecting cattle lameness, sickness, or gait abnormalities using publicly available video data. The dataset consists of 50 unique videos from 40 individual cattle, recorded from various angles in both indoor and outdoor environments. Half of the dataset represents naturally walking (normal/non-lame) cattle, while the other half consists of cattle exhibiting gait abnormalities (lame). To enhance model robustness and generalizability, data augmentation was applied to the training data. The pre-processed videos were then classified using two deep learning models: ConvLSTM2D and 3D CNN. A comparative analysis of the results demonstrates strong classification performance. Specifically, the 3D CNN model achieved a video-level classification accuracy of 90%, with precision, recall, and f1-score of 90.9%, 90.9%, and 90.91% respectively. The ConvLSTM2D model exhibited a slightly lower accuracy of 85%. This study highlights the effectiveness of directly applying classification models to learn spatiotemporal features from video data, offering an alternative to traditional multi-stage approaches that typically involve object detection, pose estimation, and feature extraction. Besides, the findings demonstrate that the proposed deep learning models, particularly the 3D CNN, effectively classify and detect lameness in cattle while simplifying the processing pipeline.
Liquid lens based holographic camera for real 3D scene hologram acquisition using end-to-end physical model-driven network
Authors: Di Wang1, Zhao-Song Li1, Yi Zheng1, You-Ran Zhao1, Chao Liu, Jin-Bo Xu, Yi-Wei Zheng, Qian Huang, Chen-Liang Chang, Da-Wei Zhang, Song-Lin Zhuang and Qiong-Hua Wang
Date: 2024-04-29 00:00:00
Proceeding: light: science & applications 2024 4

With the development of artificial intelligence, neural network provides unique opportunities for holography, such as
high fidelity and dynamic calculation. How to obtain real 3D scene and generate high fidelity hologram in real time is
an urgent problem. Here, we propose a liquid lens based holographic camera for real 3D scene hologram acquisition
using an end-to-end physical model-driven network (EEPMD-Net). As the core component of the liquid camera, the
first 10 mm large aperture electrowetting-based liquid lens is proposed by using specially fabricated solution. The
design of the liquid camera ensures that the multi-layers of the real 3D scene can be obtained quickly and with great
imaging performance. The EEPMD-Net takes the information of real 3D scene as the input, and uses two new
structures of encoder and decoder networks to realize low-noise phase generation. By comparing the intensity
information between the reconstructed image after depth fusion and the target scene, the composite loss function is
constructed for phase optimization, and the high-fidelity training of hologram with true depth of the 3D scene is
realized for the first time. The holographic camera achieves the high-fidelity and fast generation of the hologram of
the real 3D scene, and the reconstructed experiment proves that the holographic image has the advantage of low
noise. The proposed holographic camera is unique and can be used in 3D display, measurement, encryption and other
fields.