pwc-archive/papers-with-abstracts huggingface dataset:
Transforming H&E images into IHC: A Variance-Penalized GAN for Precision Oncology
Authors: Sara Rehmat, Hafeez Ur Rehman
Date: 2025-06-23 00:00:00
Tasks: Image-to-Image Translation, Specificity, SSIM

The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cells is a key driver of HER2-positive breast cancer, a highly aggressive subtype requiring precise diagnosis and targeted therapy. Immunohistochemistry (IHC) is the standard technique for HER2 assessment but is costly, labor-intensive, and highly dependent on antibody selection. In contrast, hematoxylin and eosin (H&E) staining, a routine histopathological procedure, offers broader accessibility but lacks HER2 specificity. This study proposes an advanced deep learning-based image translation framework to generate highfidelity IHC images from H&E-stained tissue samples, enabling cost-effective and scalable HER2 assessment. By modifying the loss function of pyramid pix2pix, we mitigate mode collapse, a fundamental limitation in generative adversarial networks (GANs), and introduce a novel variance-based penalty that enforces structural diversity in generated images. Our model particularly excels in translating HER2-positive (IHC 3+) images, which have remained challenging for existing methods due to their complex morphological variations. Extensive evaluations on the BCI histopathological dataset demonstrate that our model surpasses state-of-the-art methods in terms of peak signal-tonoise ratio (PSNR), structural similarity index (SSIM), and Frechet Inception Distance (FID), particularly in accurately translating HER2-positive (IHC 3+) images. Beyond medical imaging, our model exhibits superior performance in general image-to-image translation tasks, showcasing its potential across multiple domains. This work marks a significant step toward AI-driven precision oncology, offering a reliable and efficient alternative to traditional HER2 diagnostics.
Rethinking Decoder Design: Improving Biomarker Segmentation Using Depth-to-Space Restoration and Residual Linear Attention
Authors: Saad Wazir, Daeyoung Kim
Date: 2025-06-23 00:00:00
Proceeding: CVPR 2025 1
Tasks: Decoder, Image Segmentation, Medical Image Segmentation, Semantic Segmentation

Segmenting biomarkers in medical images is crucial for various biotech applications. Despite advances, Transformer and CNN based methods often struggle with variations in staining and morphology, limiting feature extraction. In medical image segmentation, where datasets often have limited sample availability, recent state-of-the-art (SOTA) methods achieve higher accuracy by leveraging pre-trained encoders, whereas end-to-end methods tend to underperform. This is due to challenges in effectively transferring rich multiscale features from encoders to decoders, as well as limitations in decoder efficiency. To address these issues, we propose an architecture that captures multi-scale local and global contextual information and a novel decoder design, which effectively integrates features from the encoder, emphasizes important channels and regions, and reconstructs spatial dimensions to enhance segmentation accuracy. Our method, compatible with various encoders, outperforms SOTA methods, as demonstrated by experiments on four datasets and ablation studies. Specifically, our method achieves absolute performance gains of 2.76% on MoNuSeg, 3.12% on DSB, 2.87% on Electron Microscopy, and 4.03% on TNBC datasets compared to existing SOTA methods. Code: https://github.com/saadwazir/MCADS-Decoder
A Multi-Scale Spatial Attention-Based Zero-Shot Learning Framework for Low-Light Image Enhancement
Authors: Muhammad Azeem Aslam, Hassan Khalid, Nisar Ahmed
Date: 2025-06-23 00:00:00
Tasks: Autonomous Navigation, Computational Efficiency, Image Enhancement, Low-Light Image Enhancement, Zero-Shot Learning

Low-light image enhancement remains a challenging task, particularly in the absence of paired training data. In this study, we present LucentVisionNet, a novel zero-shot learning framework that addresses the limitations of traditional and deep learning-based enhancement methods. The proposed approach integrates multi-scale spatial attention with a deep curve estimation network, enabling fine-grained enhancement while preserving semantic and perceptual fidelity. To further improve generalization, we adopt a recurrent enhancement strategy and optimize the model using a composite loss function comprising six tailored components, including a novel no-reference image quality loss inspired by human visual perception. Extensive experiments on both paired and unpaired benchmark datasets demonstrate that LucentVisionNet consistently outperforms state-of-the-art supervised, unsupervised, and zero-shot methods across multiple full-reference and no-reference image quality metrics. Our framework achieves high visual quality, structural consistency, and computational efficiency, making it well-suited for deployment in real-world applications such as mobile photography, surveillance, and autonomous navigation.
Adaptive Mask-guided K-space Diffusion for Accelerated MRI Reconstruction
Authors: Qinrong Cai, Yu Guan, Zhibo Chen, Dong Liang, Qiuyun Fan, Qiegen Liu
Date: 2025-06-23 00:00:00
Tasks: MRI Reconstruction

As the deep learning revolution marches on, masked modeling has emerged as a distinctive approach that involves predicting parts of the original data that are proportionally masked during training, and has demonstrated exceptional performance in multiple fields. Magnetic Resonance Imaging (MRI) reconstruction is a critical task in medical imaging that seeks to recover high-quality images from under-sampled k-space data. However, previous MRI reconstruction strategies usually optimized the entire image domain or k-space, without considering the importance of different frequency regions in the k-space This work introduces a diffusion model based on adaptive masks (AMDM), which utilizes the adaptive adjustment of frequency distribution based on k-space data to develop a hybrid masks mechanism that adapts to different k-space inputs. This enables the effective separation of high-frequency and low-frequency components, producing diverse frequency-specific representations. Additionally, the k-space frequency distribution informs the generation of adaptive masks, which, in turn, guide a closed-loop diffusion process. Experimental results verified the ability of this method to learn specific frequency information and thereby improved the quality of MRI reconstruction, providing a flexible framework for optimizing k-space data using masks in the future.
A Prior-Guided Joint Diffusion Model in Projection Domain for PET Tracer Conversion
Authors: Fang Chen, Weifeng Zhang, Xingyu Ai, Bingxuan Li, An Li, Qiegen Liu
Date: 2025-06-20 00:00:00
Tasks: Image Reconstruction, Specificity

Positron emission tomography (PET) is widely used to assess metabolic activity, but its application is limited by the availability of radiotracers. 18F-labeled fluorodeoxyglucose (18F-FDG) is the most commonly used tracer but shows limited effectiveness for certain tumors. In contrast, 6-18F-fluoro-3,4-dihydroxy-L-phenylalanine (18F-DOPA) offers higher specificity for neuroendocrine tumors and neurological disorders. However, the complexity of its synthesis process and constraints on transportation time have limited its clinical application. Among different forms of raw data acquired by the scanner, sinogram is a commonly used representation in PET imaging. Therefore, modeling in projection domain enables more direct utilization of the original information, potentially reducing the accumulation errors during the image reconstruction process. Inspired by these factors, this study proposes a prior-guided joint diffusion model (PJDM) for transforming 18F-FDG PET sinograms into 18F-DOPA PET sinograms. During inference, an initial synthetic 18F-DOPA PET sinogram is first generated using a higher-order hybrid sampler. This sinogram is then degraded and serves as an additional condition to guide the iterative refinement process. Experimental results demonstrated that PJDM effectively improved both sinogram quality and the final synthetic outcomes. The code is available at: https://github.com/yqx7150/PJDM.
STACT-Time: Spatio-Temporal Cross Attention for Cine Thyroid Ultrasound Time Series Classification
Authors: Irsyad Adam, Tengyue Zhang, Shrayes Raman, Zhuyu Qiu, Brandon Taraku, Hexiang Feng, Sile Wang, Ashwath Radhachandran, Shreeram Athreya, Vedrana Ivezic, Peipei Ping, Corey Arnold, William Speier
Date: 2025-06-22 00:00:00
Tasks: Time Series, Time Series Classification

Thyroid cancer is among the most common cancers in the United States. Thyroid nodules are frequently detected through ultrasound (US) imaging, and some require further evaluation via fine-needle aspiration (FNA) biopsy. Despite its effectiveness, FNA often leads to unnecessary biopsies of benign nodules, causing patient discomfort and anxiety. To address this, the American College of Radiology Thyroid Imaging Reporting and Data System (TI-RADS) has been developed to reduce benign biopsies. However, such systems are limited by interobserver variability. Recent deep learning approaches have sought to improve risk stratification, but they often fail to utilize the rich temporal and spatial context provided by US cine clips, which contain dynamic global information and surrounding structural changes across various views. In this work, we propose the Spatio-Temporal Cross Attention for Cine Thyroid Ultrasound Time Series Classification (STACT-Time) model, a novel representation learning framework that integrates imaging features from US cine clips with features from segmentation masks automatically generated by a pretrained model. By leveraging self-attention and cross-attention mechanisms, our model captures the rich temporal and spatial context of US cine clips while enhancing feature representation through segmentation-guided learning. Our model improves malignancy prediction compared to state-of-the-art models, achieving a cross-validation precision of 0.91 (plus or minus 0.02) and an F1 score of 0.89 (plus or minus 0.02). By reducing unnecessary biopsies of benign nodules while maintaining high sensitivity for malignancy detection, our model has the potential to enhance clinical decision-making and improve patient outcomes.
CT Radiomics-Based Explainable Machine Learning Model for Accurate Differentiation of Malignant and Benign Endometrial Tumors: A Two-Center Study
Authors: Tingrui Zhang, Honglin Wu, Zekun Jiang, Yingying Wang, Rui Ye, Huiming Ni, Chang Liu, Jin Cao, Xuan Sun, Rong Shao, Xiaorong Wei, Yingchun Sun
Date: 2025-06-22 00:00:00
Tasks: Diagnostic, Specificity

Aimed to develop and validate a CT radiomics-based explainable machine learning model for diagnosing malignancy and benignity specifically in endometrial cancer (EC) patients. A total of 83 EC patients from two centers, including 46 with malignant and 37 with benign conditions, were included, with data split into a training set (n=59) and a testing set (n=24). The regions of interest (ROIs) were manually segmented from pre-surgical CT scans, and 1132 radiomic features were extracted from the pre-surgical CT scans using Pyradiomics. Six explainable machine learning modeling algorithms were implemented respectively, for determining the optimal radiomics pipeline. The diagnostic performance of the radiomic model was evaluated by using sensitivity, specificity, accuracy, precision, F1 score, confusion matrices, and ROC curves. To enhance clinical understanding and usability, we separately implemented SHAP analysis and feature mapping visualization, and evaluated the calibration curve and decision curve. By comparing six modeling strategies, the Random Forest model emerged as the optimal choice for diagnosing EC, with a training AUC of 1.00 and a testing AUC of 0.96. SHAP identified the most important radiomic features, revealing that all selected features were significantly associated with EC (P < 0.05). Radiomics feature maps also provide a feasible assessment tool for clinical applications. DCA indicated a higher net benefit for our model compared to the "All" and "None" strategies, suggesting its clinical utility in identifying high-risk cases and reducing unnecessary interventions. In conclusion, the CT radiomics-based explainable machine learning model achieved high diagnostic performance, which could be used as an intelligent auxiliary tool for the diagnosis of endometrial cancer.
Multimodal Medical Image Binding via Shared Text Embeddings
Authors: Yunhao Liu, SuYang Xi, Shiqi Liu, Hong Ding, Chicheng Jin, Chenxi Yang, Junjun He, Yiqing Shen
Date: 2025-06-22 00:00:00
Tasks: Cross-Modal Retrieval, Medical Image Analysis

Medical image analysis increasingly relies on the integration of multiple imaging modalities to capture complementary anatomical and functional information, enabling more accurate diagnosis and treatment planning. Achieving aligned feature representations across these diverse modalities is therefore important for effective multimodal analysis. While contrastive language-image pre-training (CLIP) and its variant have enabled image-text alignments, they require explicitly paired data between arbitrary two modalities, which is difficult to acquire in medical contexts. To address the gap, we present Multimodal Medical Image Binding with Text (M\textsuperscript{3}Bind), a novel pre-training framework that enables seamless alignment of multiple medical imaging modalities through a shared text representation space without requiring explicit paired data between any two medical image modalities. Specifically, based on the insight that different images can naturally bind with text, M\textsuperscript{3}Bind first fine-tunes pre-trained CLIP-like image-text models to align their modality-specific text embedding space while preserving their original image-text alignments. Subsequently, we distill these modality-specific text encoders into a unified model, creating a shared text embedding space. Experiments on X-ray, CT, retina, ECG, and pathological images on multiple downstream tasks demonstrate that M\textsuperscript{3}Bind achieves state-of-the-art performance in zero-shot, few-shot classification and cross-modal retrieval tasks compared to its CLIP-like counterparts. These results validate M\textsuperscript{3}Bind's effectiveness in achieving cross-image-modal alignment for medical analysis.
Mobile Image Analysis Application for Mantoux Skin Test
Authors: Liong Gele, Tan Chye Cheah
Date: 2025-06-22 00:00:00
Tasks: 3D Reconstruction, Edge Detection, Image Segmentation, Management, Semantic Segmentation

This paper presents a newly developed mobile application designed to diagnose Latent Tuberculosis Infection (LTBI) using the Mantoux Skin Test (TST). Traditional TST methods often suffer from low follow-up return rates, patient discomfort, and subjective manual interpretation, particularly with the ball-point pen method, leading to misdiagnosis and delayed treatment. Moreover, previous developed mobile applications that used 3D reconstruction, this app utilizes scaling stickers as reference objects for induration measurement. This mobile application integrates advanced image processing technologies, including ARCore, and machine learning algorithms such as DeepLabv3 for robust image segmentation and precise measurement of skin indurations indicative of LTBI. The system employs an edge detection algorithm to enhance accuracy. The application was evaluated against standard clinical practices, demonstrating significant improvements in accuracy and reliability. This innovation is crucial for effective tuberculosis management, especially in resource-limited regions. By automating and standardizing TST evaluations, the application enhances the accessibility and efficiency of TB di-agnostics. Future work will focus on refining machine learning models, optimizing measurement algorithms, expanding functionalities to include comprehensive patient data management, and enhancing ARCore's performance across various lighting conditions and operational settings.
Cloud-Aware SAR Fusion for Enhanced Optical Sensing in Space Missions
Authors: Trong-An Bui, Thanh-Thoai Le
Date: 2025-06-22 00:00:00
Tasks: Disaster Response, Image Reconstruction, SSIM

Cloud contamination significantly impairs the usability of optical satellite imagery, affecting critical applications such as environmental monitoring, disaster response, and land-use analysis. This research presents a Cloud-Attentive Reconstruction Framework that integrates SAR-optical feature fusion with deep learning-based image reconstruction to generate cloud-free optical imagery. The proposed framework employs an attention-driven feature fusion mechanism to align complementary structural information from Synthetic Aperture Radar (SAR) with spectral characteristics from optical data. Furthermore, a cloud-aware model update strategy introduces adaptive loss weighting to prioritize cloud-occluded regions, enhancing reconstruction accuracy. Experimental results demonstrate that the proposed method outperforms existing approaches, achieving a PSNR of 31.01 dB, SSIM of 0.918, and MAE of 0.017. These outcomes highlight the framework's effectiveness in producing high-fidelity, spatially and spectrally consistent cloud-free optical images.
StainPIDR: A Pathological Image Decouplingand Reconstruction Method for Stain Normalization Based on Color Vector Quantization and Structure Restaining
Authors: Zheng Chen
Date: 2025-06-22 00:00:00
Tasks: Diagnostic, Quantization

The color appearance of a pathological image is highly related to the imaging protocols, the proportion of different dyes, and the scanning devices. Computer-aided diagnostic systems may deteriorate when facing these color-variant pathological images. In this work, we propose a stain normalization method called StainPIDR. We try to eliminate this color discrepancy by decoupling the image into structure features and vector-quantized color features, restaining the structure features with the target color features, and decoding the stained structure features to normalized pathological images. We assume that color features decoupled by different images with the same color should be exactly the same. Under this assumption, we train a fixed color vector codebook to which the decoupled color features will map. In the restaining part, we utilize the cross-attention mechanism to efficiently stain the structure features. As the target color (decoupled from a selected template image) will also affect the performance of stain normalization, we further design a template image selection algorithm to select a template from a given dataset. In our extensive experiments, we validate the effectiveness of StainPIDR and the template image selection algorithm. All the results show that our method can perform well in the stain normalization task. The code of StainPIDR will be publicly available later.
Robust Foreground-Background Separation for Severely-Degraded Videos Using Convolutional Sparse Representation Modeling
Authors: Kazuki Naganuma, Shunsuke Ono
Date: 2025-06-21 00:00:00

This paper proposes a foreground-background separation (FBS) method with a novel foreground model based on convolutional sparse representation (CSR). In order to analyze the dynamic and static components of videos acquired under undesirable conditions, such as hardware, environmental, and power limitations, it is essential to establish an FBS method that can handle videos with low frame rates and various types of noise. Existing FBS methods have two limitations that prevent us from accurately separating foreground and background components from such degraded videos. First, they only capture either data-specific or general features of the components. Second, they do not include explicit models for various types of noise to remove them in the FBS process. To this end, we propose a robust FBS method with a CSR-based foreground model. This model can adaptively capture specific spatial structures scattered in imaging data. Then, we formulate FBS as a constrained multiconvex optimization problem that incorporates CSR, functions that capture general features, and explicit noise characterization functions for multiple types of noise. Thanks to these functions, our method captures both data-specific and general features to accurately separate the components from various types of noise even under low frame rates. To obtain a solution of the optimization problem, we develop an algorithm that alternately solves its two convex subproblems by newly established algorithms. Experiments demonstrate the superiority of our method over existing methods using two types of degraded videos: infrared and microscope videos.
Model-Agnostic, Temperature-Informed Sampling Enhances Cross-Year Crop Mapping with Deep Learning
Authors: Mehmet Ozgur Turkoglu, Selene Ledain, Helge Aasen
Date: 2025-06-15 00:00:00
Tasks: Crop Type Mapping, Time Series, Uncertainty Quantification

Conventional benchmarks for crop type classification from optical satellite time series typically assume access to labeled data from the same year and rely on fixed calendar-day sampling. This limits generalization across seasons, where crop phenology shifts due to interannual climate variability, and precludes real-time application when current-year labels are unavailable. Furthermore, uncertainty quantification is often neglected, making such approaches unreliable for crop monitoring applications. Inspired by ecophysiological principles of plant growth, we propose a simple, model-agnostic sampling strategy that leverages growing degree days (GDD), based on daily average temperature, to replace calendar time with thermal time. By uniformly subsampling time series in this biologically meaningful domain, the method emphasizes phenologically active growth stages while reducing temporal redundancy and noise. We evaluate the method on a multi-year Sentinel-2 dataset spanning all of Switzerland, training on one growing season and testing on other seasons. Compared to state-of-the-art baselines, our method delivers substantial gains in classification accuracy and, critically, produces more calibrated uncertainty estimates. Notably, our method excels in low-data regimes and enables significantly more accurate early-season classification. With only 10 percent of the training data, our method surpasses the state-of-the-art baseline in both predictive accuracy and uncertainty estimation, and by the end of June, it achieves performance similar to a baseline trained on the full season. These results demonstrate that leveraging temperature data not only improves predictive performance across seasons but also enhances the robustness and trustworthiness of crop-type mapping in real-world applications.