pwc-archive/papers-with-abstracts huggingface dataset:
Embedded digital phase noise analyzer for optical frequency metrology
Authors: Simone Donadello, Elio K. Bertacco, Davide Calonico, Cecilia Clivati
Date: 2023-02-03 00:00:00

Digital signal processing (DSP) is supporting novel in-field applications of optical interferometry, such as in laser ranging and distributed acoustic sensing. While the highest performances are achieved with field-programmable gated arrays (FPGAs), their complexity and cost are often too high for many tasks. Here, we describe an alternative solution for processing optical signals in real-time, based on a dual-core 32-bit microcontroller. We implemented in-phase and quadrature (IQ) demodulation of optical beat-notes resulting from the interference of independent laser sources, phase noise analysis of deployed optical fibers covering intercity distances, and synchronization of remote acquisitions via optical trigger signals. The embedded architecture can efficiently accomplish a large variety of tasks in the context of optical signal processing, being also easily configurable, compact, and upgradable. These features make it attractive for applications that require long-term, remotely operated, and field-deployed instrumentation.
Covariate Adjustment in Stratified Experiments
Authors: Max Cytrynbaum
Date: 2023-02-07 00:00:00
Tasks: regression

This paper studies covariate adjusted estimation of the average treatment effect in stratified experiments. We work in a general framework that includes matched tuples designs, coarse stratification, and complete randomization as special cases. Regression adjustment with treatment-covariate interactions is known to weakly improve efficiency for completely randomized designs. By contrast, we show that for stratified designs such regression estimators are generically inefficient, potentially even increasing estimator variance relative to the unadjusted benchmark. Motivated by this result, we derive the asymptotically optimal linear covariate adjustment for a given stratification. We construct several feasible estimators that implement this efficient adjustment in large samples. In the special case of matched pairs, for example, the regression including treatment, covariates, and pair fixed effects is asymptotically optimal. We also provide novel asymptotically exact inference methods that allow researchers to report smaller confidence intervals, fully reflecting the efficiency gains from both stratification and adjustment. Simulations and an empirical application demonstrate the value of our proposed methods.
High-Dimensional Conditionally Gaussian State Space Models with Missing Data
Authors: Joshua C. C. Chan, Aubrey Poon, Dan Zhu
Date: 2023-02-07 00:00:00
Tasks: State Space Models, Vocal Bursts Intensity Prediction

We develop an efficient sampling approach for handling complex missing data patterns and a large number of missing observations in conditionally Gaussian state space models. Two important examples are dynamic factor models with unbalanced datasets and large Bayesian VARs with variables in multiple frequencies. A key insight underlying the proposed approach is that the joint distribution of the missing data conditional on the observed data is Gaussian. Moreover, the inverse covariance or precision matrix of this conditional distribution is sparse, and this special structure can be exploited to substantially speed up computations. We illustrate the methodology using two empirical applications. The first application combines quarterly, monthly and weekly data using a large Bayesian VAR to produce weekly GDP estimates. In the second application, we extract latent factors from unbalanced datasets involving over a hundred monthly variables via a dynamic factor model with stochastic volatility.
Permutation inference with a finite number of heterogeneous clusters
Authors: Andreas Hagemann
Date: 2019-07-01 00:00:00

I introduce a simple permutation procedure to test conventional (non-sharp) hypotheses about the effect of a binary treatment in the presence of a finite number of large, heterogeneous clusters when the treatment effect is identified by comparisons across clusters. The procedure asymptotically controls size by applying a level-adjusted permutation test to a suitable statistic. The adjustments needed for most empirically relevant situations are tabulated in the paper. The adjusted permutation test is easy to implement in practice and performs well at conventional levels of significance with at least four treated clusters and a similar number of control clusters. It is particularly robust to situations where some clusters are much more variable than others. Examples and an empirical application are provided.
Extensions for Inference in Difference-in-Differences with Few Treated Clusters
Authors: Luis Alvarez, Bruno Ferman
Date: 2023-02-06 00:00:00
Tasks: valid

In settings with few treated units, Difference-in-Differences (DID) estimators are not consistent, and are not generally asymptotically normal. This poses relevant challenges for inference. While there are inference methods that are valid in these settings, some of these alternatives are not readily available when there is variation in treatment timing and heterogeneous treatment effects; or for deriving uniform confidence bands for event-study plots. We present alternatives in settings with few treated units that are valid with variation in treatment timing and/or that allow for uniform confidence bands.
Asymptotic Representations for Sequential Decisions, Adaptive Experiments, and Batched Bandits
Authors: Keisuke Hirano, Jack R. Porter
Date: 2023-02-06 00:00:00

We develop asymptotic approximations that can be applied to sequential estimation and inference problems, adaptive randomized controlled trials, and related settings. In batched adaptive settings where the decision at one stage can affect the observation of variables in later stages, our asymptotic representation characterizes all limit distributions attainable through a joint choice of an adaptive design rule and statistics applied to the adaptively generated data. This facilitates local power analysis of tests, comparison of adaptive treatments rules, and other analyses of batchwise sequential statistical decision rules.
Regulating Oligopolistic Competition
Authors: Kai Hao Yang, Alexander K. Zentefis
Date: 2023-02-07 00:00:00

We consider the problem of how to regulate an oligopoly when firms have private information about their costs. In the environment, consumers make discrete choices over goods, and minimal structure is placed on the manner in which firms compete. In the optimal regulatory policy, the regulator need only solicit prices from firms, and based on those prices, charge them taxes or give them subsidies, and impose on each firm a ``yardstick'' price cap that depends on the posted prices of competing firms.
Monotone Function Intervals: Theory and Applications
Authors: Kai Hao Yang, Alexander K. Zentefis
Date: 2023-02-06 00:00:00

A monotone function interval is the set of monotone functions that lie pointwise between two fixed monotone functions. We characterize the set of extreme points of monotone function intervals and apply this to a number of economic settings. First, we leverage the main result to characterize the set of distributions of posterior quantiles that can be induced by a signal, with applications to political economy, Bayesian persuasion, and the psychology of judgment. Second, we combine our characterization with properties of convex optimization problems to unify and generalize seminal results in the literature on security design under adverse selection and moral hazard.
Uncertainty-Aware Multiple-Instance Learning for Reliable Classification: Application to Optical Coherence Tomography
Authors: Coen de Vente, Bram van Ginneken, Carel B. Hoyng, Caroline C. W. Klaver, Clara I. Sánchez
Date: 2023-02-06 00:00:00
Tasks: Classification, Medical Image Analysis, Multiple Instance Learning, Out of Distribution (OOD) Detection

Deep learning classification models for medical image analysis often perform well on data from scanners that were used during training. However, when these models are applied to data from different vendors, their performance tends to drop substantially. Artifacts that only occur within scans from specific scanners are major causes of this poor generalizability. We aimed to improve the reliability of deep learning classification models by proposing Uncertainty-Based Instance eXclusion (UBIX). This technique, based on multiple-instance learning, reduces the effect of corrupted instances on the bag-classification by seamlessly integrating out-of-distribution (OOD) instance detection during inference. Although UBIX is generally applicable to different medical images and diverse classification tasks, we focused on staging of age-related macular degeneration in optical coherence tomography. After being trained using images from one vendor, UBIX showed a reliable behavior, with a slight decrease in performance (a decrease of the quadratic weighted kappa ($\kappa_w$) from 0.861 to 0.708), when applied to images from different vendors containing artifacts; while a state-of-the-art 3D neural network suffered from a significant detriment of performance ($\kappa_w$ from 0.852 to 0.084) on the same test set. We showed that instances with unseen artifacts can be identified with OOD detection and their contribution to the bag-level predictions can be reduced, improving reliability without the need for retraining on new data. This potentially increases the applicability of artificial intelligence models to data from other scanners than the ones for which they were developed.
Impact of velocity and impact angle on football shot accuracy during fundamental trainings
Authors: Rahman Sahinler, Omer Burak Goktas, Berkay Mumcu, Damla Sen, Feyza Kocaturk, Huseyin Uvet
Date: 2023-02-07 00:00:00

The purpose of this research is to create a machine learning-based smart coaching approach for football that can replace manual analysis with real-time feedback for trainers. In-depth analysis of football player data by humans is time-consuming, error-prone, and requires a lot of effort. This exploratory study demonstrates the feasibility of using a machine learning algorithm to enhance the effectiveness of player monitoring and training. The suggested approach uses machine learning to generate analytical insights and enable long-term monitoring of player performance. In the future, machine learning could use this technique to offer constructive criticism of football players. The system incorporates a homemade ball-throwing mechanism capable of launching the ball in a variety of directions and at varying velocities. The ball kicker is equipped with a gyroscope and accelerometer sensors for measuring velocity and acceleration. The gathered data is filtered initially, and then the data that has been processed is fed into the machine-learning algorithm. The algorithm will be trained on player performance data and will be able to provide real-time feedback to coaches on player performance and potential areas for improvement. Additionally, the system will be able to track player progress over time and provide coaches with a comprehensive view of player development. The ultimate goal is to improve player performance and reduce the workload for coaches by automating the analysis process.
A Via-less Fully Screen-Printed Reconfigurable Intelligent Surface for 5G Millimeter Wave Communication
Authors: Yiming Yang, Ruiqi Wang, Mohammad Vaseem, Behrooz Makki, Atif Shamim
Date: 2023-02-07 00:00:00

In this paper, we propose a via-less fully screen-printed reconfigurable intelligent surface which can establish a second line-of-sight communication from 23.5GHz to 29.5GHz. By serially connecting the H shaped resonator along the H field of the incident wave, we minimize the effect of the biasing lines and make a via-less design, which reduces the fabrication difficulty and cost. The unit-cell simulation of the array with screen-printed VO2 switches shows a 215{\deg} to 160{\deg} phase shift difference between the ON and OFF states within bandwidth. During the field testing of the ideal arrays, we verify that the array can redirect the 45{\deg} incident wave to 0{\deg} reflection with a signal enhancement of at least 10 dB as compared to the array which has all unit cells in the OFF condition.
Uplink Joint Positioning and Synchronization in Cell-Free Deployments with Radio Stripes
Authors: Alessio Fascista, Benjamin J. B. Deutschmann, Musa Furkan Keskin, Thomas Wilding, Angelo Coluccia, Klaus Witrisal, Erik Leitinger, Gonzalo Seco-Granados, Henk Wymeersch
Date: 2023-02-07 00:00:00

Radio stripes (RSs) is an emerging technology in beyond 5G and 6G wireless networks to support the deployment of cell-free architectures. In this paper, we investigate the potential use of RSs to enable joint positioning and synchronization in the uplink channel at sub-6 GHz bands. The considered scenario consists of a single-antenna user equipment (UE) that communicates with a network of multiple-antenna RSs distributed over a wide area. The UE is assumed to be unsynchronized to the RSs network, while individual RSs are time- and phase-synchronized. We formulate the problem of joint estimation of position, clock offset, and phase offset of the UE and derive the corresponding maximum-likelihood (ML) estimator, both with and without exploiting carrier phase information. To gain fundamental insights into the achievable performance, we also conduct a Fisher information analysis and inspect the theoretical lower bounds numerically. Simulation results demonstrate that promising positioning and synchronization performance can be obtained in cell-free architectures supported by RSs, revealing at the same time the benefits of carrier phase exploitation through phase-synchronized RSs.
STAR-RIS-Enabled Simultaneous Indoor and Outdoor 3D Localization: Theoretical Analysis and Algorithmic Design
Authors: Jiguang He, Aymen Fakhreddine, George C. Alexandropoulos
Date: 2023-02-07 00:00:00
Tasks: Compressive Sensing

Recent research and development interests deal with metasurfaces for wireless systems beyond their consideration as intelligent tunable reflectors. Among the latest proposals is the simultaneously transmitting (a.k.a. refracting) and reflecting reconfigurable intelligent surface (STAR-RIS) which intends to enable bidirectional indoor-to-outdoor, and vice versa, communications thanks to its additional refraction capability. This double functionality provides increased flexibility in concurrently satisfying the quality-of-service requirements of users located at both sides of the metasurfaces, for example, the achievable data rate and localization accuracy. In this paper, we focus on STAR-RIS-empowered simultaneous indoor and outdoor three-dimensional (3D) localization, and study the fundamental performance limits via Fisher information analyses and Cram\'er Rao lower bounds (CRLBs). We also devise an efficient localization algorithm based on an off-grid compressive sensing (CS) technique relying on atomic norm minimization (ANM). The impact of the training overhead, the power splitting at the STAR-RIS, the power allocation between the users, the STAR-RIS size, the imperfections of the STAR-RIS-to-BS channel, as well as the role of the multi-path components on the positioning performance are assessed via extensive computer simulations. It is theoretically showcased that high-accuracy, up to centimeter level, 3D localization can be simultaneously achieved for indoor and outdoor users, which is also accomplished via the proposed ANM-based estimation algorithm.
Consistent and Asymptotically Efficient Localization from Range-Difference Measurements
Authors: Guangyang Zeng, Biqiang Mu, Ling Shi, Jiming Chen, Junfeng Wu
Date: 2023-02-07 00:00:00

We consider signal source localization from range-difference measurements. First, we give some readily-checked conditions on measurement noises and sensor deployment to guarantee the asymptotic identifiability of the model and show the consistency and asymptotic normality of the maximum likelihood (ML) estimator. Then, we devise an estimator that owns the same asymptotic property as the ML one. Specifically, we prove that the negative log-likelihood function converges to a function, which has a unique minimum and positive definite Hessian at the true source's position. Hence, it is promising to execute local iterations, e.g., the Gauss-Newton (GN) algorithm, following a consistent estimate. The main issue involved is obtaining a preliminary consistent estimate. To this aim, we construct a linear least-squares problem via algebraic operation and constraint relaxation and obtain a closed-form solution. We then focus on deriving and eliminating the bias of the linear least-squares estimator, which yields an asymptotically unbiased (thus consistent) estimate. Noting that the bias is a function of the noise variance, we further devise a consistent noise variance estimator that involves $3$-order polynomial rooting. Based on the preliminary consistent location estimate, a one-step GN iteration suffices to achieve the same asymptotic property as the ML estimator. Simulation results demonstrate the superiority of our proposed algorithm in the large sample case.
Automated Huntington's Disease Prognosis via Biomedical Signals and Shallow Machine Learning
Authors: Sucheer Maddury
Date: 2023-02-04 00:00:00
Tasks: Prognosis

Background: Huntington's disease (HD) is a rare, genetically determined brain disorder that limits the life of the patient, although early prognosis of HD can substantially improve the patient's quality of life. Current HD prognosis methods include using a variety of complex biomarkers such as clinical and imaging factors, however these methods have many shortfalls, such as their resource demand and failure to distinguish symptomatic and asymptomatic patients. Quantitative biomedical signaling has been used for diagnosis of other neurological disorders such as schizophrenia and has potential for exposing abnormalities in HD patients. Methodology: In this project, we used a premade, certified dataset collected at a clinic with 27 HD positive patients, 36 controls, and 6 unknowns with electroencephalography, electrocardiography, and functional near-infrared spectroscopy data. We first preprocessed the data and extracted a variety of features from both the transformed and raw signals, after which we applied a plethora of shallow machine learning techniques. Results: We found the highest accuracy was achieved by a scaled-out Extremely Randomized Trees algorithm, with area under the curve of the receiver operator characteristic of 0.963 and accuracy of 91.353%. The subsequent feature analysis showed that 60.865% of the features had p<0.05, with the features from the raw signal being most significant. Conclusion: The results indicate the promise of neural and cardiac signals for marking abnormalities in HD, as well as evaluating the progression of the disease in patients.
Merging satellite and gauge-measured precipitation using LightGBM with an emphasis on extreme quantiles
Authors: Hristos Tyralis, Georgia Papacharalampous, Nikolaos Doulamis, Anastasios Doulamis
Date: 2023-02-02 00:00:00
Tasks: quantile regression, Spatial Interpolation

Knowing the actual precipitation in space and time is critical in hydrological modelling applications, yet the spatial coverage with rain gauge stations is limited due to economic constraints. Gridded satellite precipitation datasets offer an alternative option for estimating the actual precipitation by covering uniformly large areas, albeit related estimates are not accurate. To improve precipitation estimates, machine learning is applied to merge rain gauge-based measurements and gridded satellite precipitation products. In this context, observed precipitation plays the role of the dependent variable, while satellite data play the role of predictor variables. Random forests is the dominant machine learning algorithm in relevant applications. In those spatial predictions settings, point predictions (mostly the mean or the median of the conditional distribution) of the dependent variable are issued. The aim of the manuscript is to solve the problem of probabilistic prediction of precipitation with an emphasis on extreme quantiles in spatial interpolation settings. Here we propose, issuing probabilistic spatial predictions of precipitation using Light Gradient Boosting Machine (LightGBM). LightGBM is a boosting algorithm, highlighted by prize-winning entries in prediction and forecasting competitions. To assess LightGBM, we contribute a large-scale application that includes merging daily precipitation measurements in contiguous US with PERSIANN and GPM-IMERG satellite precipitation data. We focus on extreme quantiles of the probability distribution of the dependent variable, where LightGBM outperforms quantile regression forests (QRF, a variant of random forests) in terms of quantile score at extreme quantiles. Our study offers understanding of probabilistic predictions in spatial settings using machine learning.
A Critical Review of the Impact of Candidate Copy Number Variants on Autism Spectrum Disorders
Authors: Seyedeh Sedigheh Abedini, Shiva Akhavan, Julian Heng, Roohallah Alizadehsani, Iman Dehzangi, Denis C. Bauer, Hamid Rokny
Date: 2023-02-07 00:00:00
Tasks: Diagnostic

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder (NDD) that is caused by genetic, epigenetic, and environmental factors. Recent advances in genomic analysis have uncovered numerous candidate genes with common and/or rare mutations that increase susceptibility to ASD. In addition, there is increasing evidence that copy number variations (CNVs), single nucleotide polymorphisms (SNPs), and unusual de novo variants negatively affect neurodevelopment pathways in various ways. The overall rate of copy number variants found in patients with autism is 10%-20%, of which 3%-7% can be detected cytogenetically. Although the role of submicroscopic CNVs in ASD has been studied recently, their association with genomic loci and genes has not been properly studied. In this review, we focus on 47 ASD-associated CNV regions and their related genes. Here, we identify 1,632 protein-coding genes and long non-coding RNAs (lncRNAs) within these regions. Among them, 552 are significantly expressed in the brain. Using a list of ASD-associated genes from SFARI, we detect 17 regions containing at least one known ASD-associated protein-coding genes. Of the remaining 30 regions, we identify 24 regions containing at least one protein-coding genes with brain-enriched expression and nervous system phenotype in mouse mutant and one lncRNAs with both brain-enriched expression and upregulation in iPSC to neuron differentiation. Our analyses highlight the diversity of genetic lesions of CNV regions that contribute to ASD and provide new genetic evidence that lncRNA genes may contribute to etiology of ASD. In addition, the discovered CNVs will be a valuable resource for diagnostic facilities, therapeutic strategies, and research in terms of variation priority.