pwc-archive/papers-with-abstracts huggingface dataset:
Dynamic Return and Star-Shaped Risk Measures via BSDEs
Authors: Roger J. A. Laeven, Emanuela Rosazza Gianin, Marco Zullino
Date: 2023-07-07 00:00:00

This paper establishes characterization results for dynamic return and star-shaped risk measures induced via backward stochastic differential equations (BSDEs). We first characterize a general family of static star-shaped functionals in a locally convex Fr\'echet lattice. Next, employing the Pasch-Hausdorff envelope, we build a suitable family of convex drivers of BSDEs inducing a corresponding family of dynamic convex risk measures of which the dynamic return and star-shaped risk measures emerge as the essential minimum. Furthermore, we prove that if the set of star-shaped supersolutions of a BSDE is not empty, then there exists, for each terminal condition, at least one convex BSDE with a non-empty set of supersolutions, yielding the minimal star-shaped supersolution. We illustrate our theoretical results in a few examples and demonstrate their usefulness in two applications, to capital allocation and portfolio choice.
Exploring The Contribution of Innate Immune Cells to Breast Cancer Immunotherapy
Authors: Grace Sun, Sandip Patel
Date: 2023-07-06 00:00:00
Tasks: Prognosis

Breast cancer is the leading type of cancer in women. About 10-15% of breast cancers are triple-negative breast cancer (TNBC), a subtype with the worst prognosis. Due to the lack of estrogen, progesterone and HER2 receptor expression, chemotherapies have been the standard of care for decades. Immunotherapy has emerged as promising for TNBC treatment. In 2020, the Food and Drug Administration (FDA) granted approval to pembrolizumab in combination with chemotherapy for patients with advanced triple-negative breast cancer. However, only a subgroup of advanced TNBC patients live longer whose tumors have a PD-L1 Combined Positive Score of at least 10 (CPS>=10). There is still an unmet medical need to provide alternative treatment for the rest of patients. Interestingly, a few of patients at UCSD Moores Cancer Center were found to have had excellent responses to pembrolizumab despite low CPS scores (termed Elite Responders). The hypothesis of this project is that there may be an alternative immune response mechanism and/or crosstalk happening between the innate and adaptive immune systems, especially in Natural Killer Cells and Macrophages, that contributed to this unexpected excellent response. Our procedure used ACDBio RNAscope Multiplex Fluorescence v2 method to spatially analyze innate immune cells (Natural Killer cells and macrophages) and adaptive immune cells (T-cells) in the Tumor Micro Environment. Our data demonstrated increased tumor infiltration of innate immune cells (macrophage and Natural Killer cells) in the Elite Responders. This conclusion indicated the joint effort of two immune systems (innate and adaptive) which eventually led to increased survival.
Comparative Analysis of Kinetic Realizations of Insulin Signaling
Authors: Patrick Vincent N. Lubenia, Eduardo R. Mendoza, Angelyn R. Lao
Date: 2023-07-07 00:00:00

Several studies have developed dynamical models to understand the underlying mechanisms of insulin signaling, a signaling cascade that leads to the translocation of glucose, the human body's main source of energy. Fortunately, reaction network analysis allows us to extract properties of dynamical systems without depending on their model parameter values. This study focuses on the comparison of insulin signaling in healthy state (INSMS or INSulin Metabolic Signaling) and in type 2 diabetes (INRES or INsulin RESistance) using reaction network analysis. The analysis uses network decomposition to identify the different subsystems involved in insulin signaling (e.g., insulin receptor binding and recycling, GLUT4 translocation, and ERK signaling pathway, among others). Furthermore, results show that INSMS and INRES are similar with respect to some network, structo-kinetic, and kinetic properties. Their differences, however, provide insights into what happens when insulin resistance occurs. First, the variation in the number of species involved in INSMS and INRES suggests that when irregularities occur in the insulin signaling pathway, other complexes (and, hence, other processes) get involved, characterizing insulin resistance. Second, the loss of concordance exhibited by INRES suggests less restrictive interplay between the species involved in insulin signaling, leading to unusual activities in the signaling cascade. Lastly, GLUT4 losing its absolute concentration robustness in INRES may signify that the transporter has lost its reliability in shuttling glucose to the cell, inhibiting efficient cellular energy production. This study also suggests possible applications of the equilibria parametrization and network decomposition, resulting from the analysis, to potentially establish absolute concentration robustness in a species.
Persistent disruption of interspecific competition after ultra-low esfenvalerate exposure
Authors: Florian Schunck, Matthias Liess
Date: 2023-07-07 00:00:00

Field and mesocosm studies repeatedly show that higher tier process reduce the predictive accuracy of toxicity evaluation and consequently their value for pesticide risk assessment. Therefore, understanding the influence of ecological complexity on toxicant effects is crucial to improve realism of aquatic risk assessment. Here we investigate the influence of repeated exposure to ecologically realistic concentrations of esfenvalerate on the similarly sensitive species Daphnia magna and Culex pipiens in a food limited and highly competitive environment. We show that significant perturbations in population development are only present close to the EC50. In contrast, interspecific competition between species is already reduced at concentrations 3-4 orders of magnitude below the acute EC50. We conclude that extremely low, environmentally relevant concentrations can disrupt species interactions. This toxicant mediated alteration of competitive balances in ecological communities may be the underlying mechanism for shifts in species distribution at ultra-low pesticide concentrations. A realistic risk assessment should therefore consider these processes in order to predict potential pesticide effects on the structure of communities.
Differences between the true reproduction number and the apparent reproduction number of an epidemic time series
Authors: Oliver Eales, Steven Riley
Date: 2023-07-07 00:00:00
Tasks: Time Series

The time-varying reproduction number $R(t)$ measures the number of new infections per infectious individual and is closely correlated with the time series of infection incidence by definition. The timings of actual infections are rarely known, and analysis of epidemics usually relies on time series data for other outcomes such as symptom onset. A common implicit assumption, when estimating $R(t)$ from an epidemic time series, is that $R(t)$ has the same relationship with these downstream outcomes as it does with the time series of incidence. However, this assumption is unlikely to be valid given that most epidemic time series are not perfect proxies of incidence. Rather they represent convolutions of incidence with uncertain delay distributions. Here we define the apparent time-varying reproduction number, $R_A(t)$, the reproduction number calculated from a downstream epidemic time series and demonstrate how differences between $R_A(t)$ and $R(t)$ depend on the convolution function. The mean of the convolution function sets a time offset between the two signals, whilst the variance of the convolution function introduces a relative distortion between them. We present the convolution functions of epidemic time series that were available during the SARS-CoV-2 pandemic. Infection prevalence, measured by random sampling studies, presents fewer biases than other epidemic time series. Here we show that additionally the mean and variance of its convolution function were similar to that obtained from traditional surveillance based on mass-testing and could be reduced using more frequent testing, or by using stricter thresholds for positivity. Infection prevalence studies continue to be a versatile tool for tracking the temporal trends of $R(t)$, and with additional refinements to their study protocol, will be of even greater utility during any future epidemics or pandemics.
Solving stochastic gene expression models using queueing theory: a tutorial review
Authors: Juraj Szavits-Nossan, Ramon Grima
Date: 2023-07-06 00:00:00

Stochastic models of gene expression are typically formulated using the chemical master equation, which can be solved exactly or approximately using a repertoire of analytical methods. Here, we provide a tutorial review of an alternative approach based on queueing theory that has rarely been used in the literature of gene expression. We discuss the interpretation of six types of infinite server queues from the angle of stochastic single-cell biology and provide analytical expressions for the stationary and non-stationary distributions and/or moments of mRNA/protein numbers, and bounds on the Fano factor. This approach may enable the solution of complex models which have hitherto evaded analytical solution.
Decentralised Finance and Automated Market Making: Execution and Speculation
Authors: Álvaro Cartea, Fayçal Drissi, Marcello Monga
Date: 2023-07-07 00:00:00

Automated market makers (AMMs) are a new prototype of decentralised exchanges which are revolutionising market interactions. The majority of AMMs are constant product markets (CPMs) where exchange rates are set by a trading function. This work studies optimal trading and statistical arbitrage in CPMs where balancing exchange rate risk and execution costs is key. Empirical evidence shows that execution costs are accurately estimated by the convexity of the trading function. These convexity costs are linear in the trade size and are nonlinear in the depth of liquidity and in the exchange rate. We develop models for when exchange rates form in a competing centralised exchange, in a CPM, or in both venues. Finally, we derive computationally efficient strategies that account for stochastic convexity costs and we showcase their out-of-sample performance.
StyleGAN3: Generative Networks for Improving the Equivariance of Translation and Rotation
Authors: Tianlei Zhu, Junqi Chen, Renzhe Zhu, Gaurav Gupta
Date: 2023-07-08 00:00:00
Tasks: Translation

StyleGAN can use style to affect facial posture and identity features, and noise to affect hair, wrinkles, skin color and other details. Among these, the outcomes of the picture processing will vary slightly between different versions of styleGAN. As a result, the comparison of performance differences between styleGAN2 and the two modified versions of styleGAN3 will be the main focus of this study. We used the FFHQ dataset as the dataset and FID, EQ-T, and EQ-R were used to be the assessment of the model. In the end, we discovered that Stylegan3 version is a better generative network to improve the equivariance. Our findings have a positive impact on the creation of animation and videos.
Enhancing Cross-lingual Transfer via Phonemic Transcription Integration
Authors: Hoang H. Nguyen, Chenwei Zhang, Tao Zhang, Eugene Rohrbaugh, Philip S. Yu
Date: 2023-07-10 00:00:00
Tasks: Cross-Lingual Transfer, named-entity-recognition, Named Entity Recognition, Part-Of-Speech Tagging, Representation Learning

Previous cross-lingual transfer methods are restricted to orthographic representation learning via textual scripts. This limitation hampers cross-lingual transfer and is biased towards languages sharing similar well-known scripts. To alleviate the gap between languages from different writing scripts, we propose PhoneXL, a framework incorporating phonemic transcriptions as an additional linguistic modality beyond the traditional orthographic transcriptions for cross-lingual transfer. Particularly, we propose unsupervised alignment objectives to capture (1) local one-to-one alignment between the two different modalities, (2) alignment via multi-modality contexts to leverage information from additional modalities, and (3) alignment via multilingual contexts where additional bilingual dictionaries are incorporated. We also release the first phonemic-orthographic alignment dataset on two token-level tasks (Named Entity Recognition and Part-of-Speech Tagging) among the understudied but interconnected Chinese-Japanese-Korean-Vietnamese (CJKV) languages. Our pilot study reveals phonemic transcription provides essential information beyond the orthography to enhance cross-lingual transfer and bridge the gap among CJKV languages, leading to consistent improvements on cross-lingual token-level tasks over orthographic-based multilingual PLMs.
EchoVest: Real-Time Sound Classification and Depth Perception Expressed through Transcutaneous Electrical Nerve Stimulation
Authors: Jesse Choe, Siddhant Sood, Ryan Park
Date: 2023-07-10 00:00:00
Tasks: blind source separation, Classification, Environmental Sound Classification, Sound Classification

Over 1.5 billion people worldwide live with hearing impairment. Despite various technologies that have been created for individuals with such disabilities, most of these technologies are either extremely expensive or inaccessible for everyday use in low-medium income countries. In order to combat this issue, we have developed a new assistive device, EchoVest, for blind/deaf people to intuitively become more aware of their environment. EchoVest transmits vibrations to the user's body by utilizing transcutaneous electric nerve stimulation (TENS) based on the source of the sounds. EchoVest also provides various features, including sound localization, sound classification, noise reduction, and depth perception. We aimed to outperform CNN-based machine-learning models, the most commonly used machine learning model for classification tasks, in accuracy and computational costs. To do so, we developed and employed a novel audio pipeline that adapts the Audio Spectrogram Transformer (AST) model, an attention-based model, for our sound classification purposes, and Fast Fourier Transforms for noise reduction. The application of Otsu's Method helped us find the optimal thresholds for background noise sound filtering and gave us much greater accuracy. In order to calculate direction and depth accurately, we applied Complex Time Difference of Arrival algorithms and SOTA localization. Our last improvement was to use blind source separation to make our algorithms applicable to multiple microphone inputs. The final algorithm achieved state-of-the-art results on numerous checkpoints, including a 95.7\% accuracy on the ESC-50 dataset for environmental sound classification.
Divide, Evaluate, and Refine: Evaluating and Improving Text-to-Image Alignment with Iterative VQA Feedback
Authors: Jaskirat Singh, Liang Zheng
Date: 2023-07-10 00:00:00
Proceeding: NeurIPS 2023 11
Tasks: Image Generation, Visual Question Answering (VQA)

The field of text-conditioned image generation has made unparalleled progress with the recent advent of latent diffusion models. While remarkable, as the complexity of given text input increases, the state-of-the-art diffusion models may still fail in generating images which accurately convey the semantics of the given prompt. Furthermore, it has been observed that such misalignments are often left undetected by pretrained multi-modal models such as CLIP. To address these problems, in this paper we explore a simple yet effective decompositional approach towards both evaluation and improvement of text-to-image alignment. In particular, we first introduce a Decompositional-Alignment-Score which given a complex prompt decomposes it into a set of disjoint assertions. The alignment of each assertion with generated images is then measured using a VQA model. Finally, alignment scores for different assertions are combined aposteriori to give the final text-to-image alignment score. Experimental analysis reveals that the proposed alignment metric shows significantly higher correlation with human ratings as opposed to traditional CLIP, BLIP scores. Furthermore, we also find that the assertion level alignment scores provide a useful feedback which can then be used in a simple iterative procedure to gradually increase the expression of different assertions in the final image outputs. Human user studies indicate that the proposed approach surpasses previous state-of-the-art by 8.7% in overall text-to-image alignment accuracy. Project page for our paper is available at https://1jsingh.github.io/divide-evaluate-and-refine
RoCo: Dialectic Multi-Robot Collaboration with Large Language Models
Authors: Zhao Mandi, Shreeya Jain, Shuran Song
Date: 2023-07-10 00:00:00
Tasks: Trajectory Planning

We propose a novel approach to multi-robot collaboration that harnesses the power of pre-trained large language models (LLMs) for both high-level communication and low-level path planning. Robots are equipped with LLMs to discuss and collectively reason task strategies. They then generate sub-task plans and task space waypoint paths, which are used by a multi-arm motion planner to accelerate trajectory planning. We also provide feedback from the environment, such as collision checking, and prompt the LLM agents to improve their plan and waypoints in-context. For evaluation, we introduce RoCoBench, a 6-task benchmark covering a wide range of multi-robot collaboration scenarios, accompanied by a text-only dataset for agent representation and reasoning. We experimentally demonstrate the effectiveness of our approach -- it achieves high success rates across all tasks in RoCoBench and adapts to variations in task semantics. Our dialog setup offers high interpretability and flexibility -- in real world experiments, we show RoCo easily incorporates human-in-the-loop, where a user can communicate and collaborate with a robot agent to complete tasks together. See project website https://project-roco.github.io for videos and code.
Diffusion Policies for Out-of-Distribution Generalization in Offline Reinforcement Learning
Authors: Suzan Ece Ada, Erhan Oztop, Emre Ugur
Date: 2023-07-10 00:00:00
Tasks: continuous-control, Continuous Control, D4RL, Descriptive, Offline RL, Out-of-Distribution Generalization, reinforcement-learning, Reinforcement Learning (RL), Representation Learning

Offline Reinforcement Learning (RL) methods leverage previous experiences to learn better policies than the behavior policy used for data collection. However, they face challenges handling distribution shifts due to the lack of online interaction during training. To this end, we propose a novel method named State Reconstruction for Diffusion Policies (SRDP) that incorporates state reconstruction feature learning in the recent class of diffusion policies to address the problem of out-of-distribution (OOD) generalization. Our method promotes learning of generalizable state representation to alleviate the distribution shift caused by OOD states. To illustrate the OOD generalization and faster convergence of SRDP, we design a novel 2D Multimodal Contextual Bandit environment and realize it on a 6-DoF real-world UR10 robot, as well as in simulation, and compare its performance with prior algorithms. In particular, we show the importance of the proposed state reconstruction via ablation studies. In addition, we assess the performance of our model on standard continuous control benchmarks (D4RL), namely the navigation of an 8-DoF ant and forward locomotion of half-cheetah, hopper, and walker2d, achieving state-of-the-art results. Finally, we demonstrate that our method can achieve 167% improvement over the competing baseline on a sparse continuous control navigation task where various regions of the state space are removed from the offline RL dataset, including the region encapsulating the goal.
Large Language Models as General Pattern Machines
Authors: Suvir Mirchandani, Fei Xia, Pete Florence, Brian Ichter, Danny Driess, Montserrat Gonzalez Arenas, Kanishka Rao, Dorsa Sadigh, Andy Zeng
Date: 2023-07-10 00:00:00
Tasks: ARC, In-Context Learning

We observe that pre-trained large language models (LLMs) are capable of autoregressively completing complex token sequences -- from arbitrary ones procedurally generated by probabilistic context-free grammars (PCFG), to more rich spatial patterns found in the Abstraction and Reasoning Corpus (ARC), a general AI benchmark, prompted in the style of ASCII art. Surprisingly, pattern completion proficiency can be partially retained even when the sequences are expressed using tokens randomly sampled from the vocabulary. These results suggest that without any additional training, LLMs can serve as general sequence modelers, driven by in-context learning. In this work, we investigate how these zero-shot capabilities may be applied to problems in robotics -- from extrapolating sequences of numbers that represent states over time to complete simple motions, to least-to-most prompting of reward-conditioned trajectories that can discover and represent closed-loop policies (e.g., a stabilizing controller for CartPole). While difficult to deploy today for real systems due to latency, context size limitations, and compute costs, the approach of using LLMs to drive low-level control may provide an exciting glimpse into how the patterns among words could be transferred to actions.
Understanding Real-World AI Planning Domains: A Conceptual Framework
Authors: Ebaa Alnazer, Ilche Georgievski
Date: 2023-07-10 00:00:00

Planning is a pivotal ability of any intelligent system being developed for real-world applications. AI planning is concerned with researching and developing planning systems that automatically compute plans that satisfy some user objective. Identifying and understanding the relevant and realistic aspects that characterise real-world application domains are crucial to the development of AI planning systems. This provides guidance to knowledge engineers and software engineers in the process of designing, identifying, and categorising resources required for the development process. To the best of our knowledge, such support does not exist. We address this research gap by developing a conceptual framework that identifies and categorises the aspects of real-world planning domains in varying levels of granularity. Our framework provides not only a common terminology but also a comprehensive overview of a broad range of planning aspects exemplified using the domain of sustainable buildings as a prominent application domain of AI planning. The framework has the potential to impact the design, development, and applicability of AI planning systems in real-world application domains.