user: You are a structured reasoning expert tasked with solving problems step by step. 
You first think about the reasoning process in the mind and then provide the answer. The reasoning process and answer should be enclosed within <think> </think> and <answer> </answer> tags, respectively, i.e., <think> reasoning process here </think> <answer> answer here </answer>. 
Given a question and the associated knowledge graph triplets (entity, relation, entity), you are asked to answer the question with these triplets and your own knowledge. 
You can break down the original question into several sub-questions and explore the given knowledge graph to solve them step-by-step. If there are multiple possible answers, choose one as the final answer. 
After thinking, when you finally reach a conclusion, clearly state the answer within <answer> </answer> tags, i.e., <answer> answer here </answer>. 
Question: what medical trial design using rapid evaluation of amantadine for treatment of cocaine abuse/dependence – 4 has the lowest number of expected total enrollment? 
Knowledge Triplets: Alendronate and/or Parathyroid Hormone for Osteoporosis, medicine.medical_trial.design, Treatment
Cocaine-Related Disorders, medicine.disease.trials, Cocaine Effects in Humans: Physiology and Behavior – 1
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome, medicine.medical_trial.design, Blind experiment
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Evaluation of Neuromuscular Disease
Methadone Effects on Zidovudine (ZDV, AZT) Disposition, medicine.medical_trial.design, Treatment
Postmenopausal Hormone Therapy in Unstable Angina, medicine.medical_trial.health_authority, Federal government of the United States
Treatment, medicine.medical_trial_design.trials, A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Hypertension Prevention Trial (HPT) Feasibility Study
Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children, medicine.medical_trial.health_authority, Federal government of the United States
II, medicine.medical_trial_phase.medical_trials, Pharmacological Modulation of Cocaine Effects – 1
Oral Collagen for Rheumatoid Arthritis, medicine.medical_trial.phase, II
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.phase, II
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma, medicine.medical_trial.phase, II
II, medicine.medical_trial_phase.medical_trials, Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma
II, medicine.medical_trial_phase.medical_trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children, medicine.medical_trial.design, Treatment
Treatment, medicine.medical_trial_design.trials, Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
Treatment, medicine.medical_trial_design.trials, A Study of Zidovudine in HIV-Infected Patients With Liver Disease
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.expected_total_enrollment, 0
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Pharmacological Modulation of Cocaine Effects – 1
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.start_date, 1996-03
Cocaine-Related Disorders, medicine.disease.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Placebo Control, medicine.medical_trial_design.trials, Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.design, Treatment
Blind experiment, medicine.medical_trial_design.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Randomized, medicine.medical_trial_design.trials, Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder
Oral Collagen for Rheumatoid Arthritis, medicine.medical_trial.design, Treatment
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.sponsor, National Institute on Drug Abuse
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.maximum_age_for_eligibility, 65
Randomized, medicine.medical_trial_design.trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder, medicine.medical_trial.design, Randomized
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome, medicine.medical_trial.design, Placebo Control
Evaluation of Neuromuscular Disease, medicine.medical_trial.health_authority, Federal government of the United States
Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder, medicine.medical_trial.design, Treatment
Randomized, medicine.medical_trial_design.trials, Oral Collagen for Rheumatoid Arthritis
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection, medicine.medical_trial.design, Treatment
The Effects of Illnesses on HIV Levels in the Body, medicine.medical_trial.health_authority, Federal government of the United States
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Cocaine Effects in Humans: Physiology and Behavior – 1
Memantine in Systemic Lupus Erythematosus, medicine.medical_trial.design, Blind experiment
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.design, Randomized
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Postmenopausal Hormone Therapy in Unstable Angina
Blind experiment, medicine.medical_trial_design.trials, A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.location, Friends Research Institute
Hypertension Prevention Trial (HPT) Feasibility Study, medicine.medical_trial.phase, II
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.location, Los Angeles
Blind experiment, medicine.medical_trial_design.trials, Memantine in Systemic Lupus Erythematosus
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.design, Treatment
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children
Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus, medicine.medical_trial.health_authority, Federal government of the United States
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Feasibility Study of Take-Home LAAM Medication – 3
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.eligibile_genders, Female
Treatment, medicine.medical_trial_design.trials, Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.sponsor, National Institute on Drug Abuse
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.design, Randomized
Randomized, medicine.medical_trial_design.trials, Physicians' Health Study
A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients, medicine.medical_trial.design, Treatment
Memantine in Systemic Lupus Erythematosus, medicine.medical_trial.design, Randomized
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.diseases, Cocaine-Related Disorders
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
Treatment, medicine.medical_trial_design.trials, Alendronate and/or Parathyroid Hormone for Osteoporosis
Postmenopausal Hormone Therapy in Unstable Angina, medicine.medical_trial.design, Placebo Control
Postmenopausal Hormone Therapy in Unstable Angina, medicine.medical_trial.design, Blind experiment
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.phase, II
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial_design.trials, Treatment
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.primary_outcomes, Retention
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up, medicine.medical_trial.design, Randomized
II, medicine.medical_trial_phase.medical_trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Feasibility Study of Take-Home LAAM Medication – 3, medicine.medical_trial.sponsor, National Institute on Drug Abuse
Alendronate and/or Parathyroid Hormone for Osteoporosis, medicine.medical_trial.phase, II
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.diseases, Cocaine-Related Disorders
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.eligibility_exclusion_criteria, Healthy
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.health_authority, Federal government of the United States
II, medicine.medical_trial_phase.medical_trials, Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.health_authority, Federal government of the United States
Postmenopausal Hormone Therapy in Unstable Angina, medicine.medical_trial.design, Randomized
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Pharmacological Modulation of Cocaine Effects – 1
Blind experiment, medicine.medical_trial_design.trials, The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.sponsor, National Institute on Drug Abuse
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Feasibility Study of Take-Home LAAM Medication – 3
Treatment, medicine.medical_trial_design.trials, Oral Collagen for Rheumatoid Arthritis
Hypertension Prevention Trial (HPT) Feasibility Study, medicine.medical_trial.design, Randomized
II, medicine.medical_trial_phase.medical_trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Memantine in Systemic Lupus Erythematosus, medicine.medical_trial.design, Placebo Control
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.diseases, Cocaine-Related Disorders
A Study of Zidovudine in HIV-Infected Patients With Liver Disease, medicine.medical_trial.health_authority, Federal government of the United States
Placebo Control, medicine.medical_trial_design.trials, Memantine in Systemic Lupus Erythematosus
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.minimum_age_for_eligibility, 18
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.phase, II
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up, medicine.medical_trial.phase, II
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.primary_outcomes, Cocaine use
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.primary_outcomes, Psychosocial progress
Treatment, medicine.medical_trial_design.trials, The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC), medicine.medical_trial.health_authority, Federal government of the United States
Treatment, medicine.medical_trial_design.trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.design, Placebo Control
II, medicine.medical_trial_phase.medical_trials, Alendronate and/or Parathyroid Hormone for Osteoporosis
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome, medicine.medical_trial.design, Randomized
Blind experiment, medicine.medical_trial_design.trials, Physicians' Health Study
Blind experiment, medicine.medical_trial_design.trials, Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder
Randomized, medicine.medical_trial_design.trials, Memantine in Systemic Lupus Erythematosus
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection, medicine.medical_trial.health_authority, Federal government of the United States
Randomized, medicine.medical_trial_design.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Amantadine, medicine.medical_treatment.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome, medicine.medical_trial.design, Treatment
Alendronate and/or Parathyroid Hormone for Osteoporosis, medicine.medical_trial.design, Randomized
II, medicine.medical_trial_phase.medical_trials, Hypertension Prevention Trial (HPT) Feasibility Study
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.primary_outcomes, Cocaine craving
Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder, medicine.medical_trial.design, Blind experiment
Treatment, medicine.medical_trial_design.trials, Memantine in Systemic Lupus Erythematosus
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma, medicine.medical_trial.health_authority, Federal government of the United States
Physicians' Health Study, medicine.medical_trial.design, Randomized
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.clinicaltrials_identifier, NCT00000301
Treatment, medicine.medical_trial_design.trials, Methadone Effects on Zidovudine (ZDV, AZT) Disposition
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections, medicine.medical_trial.health_authority, Federal government of the United States
Randomized, medicine.medical_trial_design.trials, Postmenopausal Hormone Therapy in Unstable Angina
Randomized, medicine.medical_trial_design.trials, Hypertension Prevention Trial (HPT) Feasibility Study
Cocaine-Related Disorders, medicine.disease.trials, Pharmacological Modulation of Cocaine Effects – 1
A Study of Zidovudine in HIV-Infected Patients With Liver Disease, medicine.medical_trial.design, Treatment
Treatment, medicine.medical_trial_design.trials, Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
Placebo Control, medicine.medical_trial_design.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.design, Treatment
Randomized, medicine.medical_trial_design.trials, Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection, medicine.medical_trial.design, Blind experiment
Randomized, medicine.medical_trial_design.trials, The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.design, Blind experiment
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.eligibile_genders, Male
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Methadone Effects on Zidovudine (ZDV, AZT) Disposition
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, The Effects of Illnesses on HIV Levels in the Body
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up
Treatment, medicine.medical_trial_design.trials, A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC), medicine.medical_trial.design, Treatment
Oral Collagen for Rheumatoid Arthritis, medicine.medical_trial.design, Randomized
Hypertension Prevention Trial (HPT) Feasibility Study, medicine.medical_trial.health_authority, Federal government of the United States
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.treatment_being_tested, Amantadine
Placebo Control, medicine.medical_trial_design.trials, Postmenopausal Hormone Therapy in Unstable Angina
Treatment, medicine.medical_trial_design.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections, medicine.medical_trial.design, Treatment
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, A Study of Zidovudine in HIV-Infected Patients With Liver Disease
Treatment, medicine.medical_trial_design.trials, A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
Placebo Control, medicine.medical_trial_design.trials, The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
Treatment, medicine.medical_trial_design.trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma, medicine.medical_trial.design, Treatment
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.health_authority, Federal government of the United States
II, medicine.medical_trial_phase.medical_trials, Oral Collagen for Rheumatoid Arthritis
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.phase, II
Treatment, medicine.medical_trial_design.trials, Pharmacological Modulation of Cocaine Effects – 1
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.health_authority, Federal government of the United States
Methadone Effects on Zidovudine (ZDV, AZT) Disposition, medicine.medical_trial.health_authority, Federal government of the United States
Physicians' Health Study, medicine.medical_trial.design, Blind experiment
Randomized, medicine.medical_trial_design.trials, Alendronate and/or Parathyroid Hormone for Osteoporosis
Treatment, medicine.medical_trial_design.trials, Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up, medicine.medical_trial.design, Placebo Control
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up, medicine.medical_trial.health_authority, Federal government of the United States
Feasibility Study of Take-Home LAAM Medication – 3, medicine.medical_trial.health_authority, Federal government of the United States
Memantine in Systemic Lupus Erythematosus, medicine.medical_trial.design, Treatment
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.design, Treatment
Blind experiment, medicine.medical_trial_design.trials, Postmenopausal Hormone Therapy in Unstable Angina

Answer: Treatment