user: You are a structured reasoning expert tasked with solving problems step by step. 
You first think about the reasoning process in the mind and then provide the answer. The reasoning process and answer should be enclosed within <think> </think> and <answer> </answer> tags, respectively, i.e., <think> reasoning process here </think> <answer> answer here </answer>. 
Given a question and the associated knowledge graph triplets (entity, relation, entity), you are asked to answer the question with these triplets and your own knowledge. 
You can break down the original question into several sub-questions and explore the given knowledge graph to solve them step-by-step. If there are multiple possible answers, choose one as the final answer. 
After thinking, when you finally reach a conclusion, clearly state the answer within <answer> </answer> tags, i.e., <answer> answer here </answer>. 
Question: which medical trial designed using cocaine effects in humans: physiology and behavior – 1 has the lowest expected total enrollment? 
Knowledge Triplets: Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Methadone Effects on Zidovudine (ZDV, AZT) Disposition
Treatment, medicine.medical_trial_design.trials, A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.type_of_trial, Interventional
Interventional, medicine.medical_trial_type.medical_trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Treatment, medicine.medical_trial_design.trials, Pharmacological Modulation of Cocaine Effects – 1
Oral Collagen for Rheumatoid Arthritis, medicine.medical_trial.phase, II
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.minimum_age_for_eligibility, 18
Methadone Effects on Zidovudine (ZDV, AZT) Disposition, medicine.medical_trial.design, Treatment
Memantine in Systemic Lupus Erythematosus, medicine.medical_trial.design, Treatment
Interventional, medicine.medical_trial_type.medical_trials, Methadone Effects on Zidovudine (ZDV, AZT) Disposition
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.diseases, Cocaine-Related Disorders
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial_design.trials, Treatment
A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC), medicine.medical_trial.design, Treatment
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.sponsor, National Institute on Drug Abuse
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.primary_outcomes, Interaction of cocaine and meds on cardio
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.design, Treatment
II, medicine.medical_trial_phase.medical_trials, Pharmacological Modulation of Cocaine Effects – 1
Hypertension Prevention Trial (HPT) Feasibility Study, medicine.medical_trial.type_of_trial, Interventional
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome, medicine.medical_trial.type_of_trial, Interventional
Interventional, medicine.medical_trial_type.medical_trials, Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up, medicine.medical_trial.health_authority, Federal government of the United States
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.primary_outcomes, Effects of medication on cocaine craving
Interventional, medicine.medical_trial_type.medical_trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Methadone Effects on Zidovudine (ZDV, AZT) Disposition, medicine.medical_trial.type_of_trial, Interventional
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.phase, II
Treatment, medicine.medical_trial_design.trials, A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.type_of_trial, Interventional
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Cocaine Effects in Humans: Physiology and Behavior – 1
Nimotuzumab in Adults With Glioblastoma Multiforma, medicine.medical_trial.type_of_trial, Interventional
Interventional, medicine.medical_trial_type.medical_trials, A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.eligibile_genders, Female
Interventional, medicine.medical_trial_type.medical_trials, Physicians' Health Study
Interventional, medicine.medical_trial_type.medical_trials, A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients
Cocaine-Related Disorders, medicine.disease.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
II, medicine.medical_trial_phase.medical_trials, Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.design, Treatment
Interventional, medicine.medical_trial_type.medical_trials, Oral Collagen for Rheumatoid Arthritis
II, medicine.medical_trial_phase.medical_trials, Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma
Interventional, medicine.medical_trial_type.medical_trials, A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder, medicine.medical_trial.type_of_trial, Interventional
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.design, Treatment
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.health_authority, Federal government of the United States
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Postmenopausal Hormone Therapy in Unstable Angina
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.eligibility_exclusion_criteria, Healthy
Hypertension Prevention Trial (HPT) Feasibility Study, medicine.medical_trial.phase, II
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.diseases, Cocaine-Related Disorders
Feasibility Study of Take-Home LAAM Medication – 3, medicine.medical_trial.type_of_trial, Interventional
Evaluation of Neuromuscular Disease, medicine.medical_trial.health_authority, Federal government of the United States
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections, medicine.medical_trial.health_authority, Federal government of the United States
Alendronate and/or Parathyroid Hormone for Osteoporosis, medicine.medical_trial.design, Treatment
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.diseases, Cocaine-Related Disorders
Postmenopausal Hormone Therapy in Unstable Angina, medicine.medical_trial.health_authority, Federal government of the United States
Interventional, medicine.medical_trial_type.medical_trials, Alendronate and/or Parathyroid Hormone for Osteoporosis
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, A Study of Zidovudine in HIV-Infected Patients With Liver Disease
Cocaine-Related Disorders, medicine.disease.trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.design, Treatment
Treatment, medicine.medical_trial_design.trials, Memantine in Systemic Lupus Erythematosus
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
Treatment, medicine.medical_trial_design.trials, A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
The Effects of Illnesses on HIV Levels in the Body, medicine.medical_trial.health_authority, Federal government of the United States
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.phase, II
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection, medicine.medical_trial.health_authority, Federal government of the United States
Interventional, medicine.medical_trial_type.medical_trials, A Study of Zidovudine in HIV-Infected Patients With Liver Disease
Interventional, medicine.medical_trial_type.medical_trials, Hypertension Prevention Trial (HPT) Feasibility Study
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Feasibility Study of Take-Home LAAM Medication – 3
Hypertension Prevention Trial (HPT) Feasibility Study, medicine.medical_trial.health_authority, Federal government of the United States
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4, medicine.medical_trial.health_authority, Federal government of the United States
II, medicine.medical_trial_phase.medical_trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Columbia University, medicine.medical_trial_sponsor.trials_sponsored, Cocaine Effects in Humans: Physiology and Behavior – 1
Alendronate and/or Parathyroid Hormone for Osteoporosis, medicine.medical_trial.phase, II
Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder, medicine.medical_trial.design, Treatment
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections, medicine.medical_trial.type_of_trial, Interventional
Interventional, medicine.medical_trial_type.medical_trials, Feasibility Study of Take-Home LAAM Medication – 3
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus
Treatment, medicine.medical_trial_design.trials, Methadone Effects on Zidovudine (ZDV, AZT) Disposition
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up, medicine.medical_trial.phase, II
Interventional, medicine.medical_trial_type.medical_trials, Pharmacological Modulation of Cocaine Effects – 1
Memantine in Systemic Lupus Erythematosus, medicine.medical_trial.type_of_trial, Interventional
II, medicine.medical_trial_phase.medical_trials, Hypertension Prevention Trial (HPT) Feasibility Study
Treatment, medicine.medical_trial_design.trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC), medicine.medical_trial.health_authority, Federal government of the United States
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, The Effects of Illnesses on HIV Levels in the Body
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.health_authority, Federal government of the United States
II, medicine.medical_trial_phase.medical_trials, Cocaine Effects in Humans: Physiology and Behavior – 1
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome, medicine.medical_trial.design, Treatment
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.primary_outcomes, Interaction of cocaine & meds on coc's subjective
Interventional, medicine.medical_trial_type.medical_trials, Postmenopausal Hormone Therapy in Unstable Angina
Treatment, medicine.medical_trial_design.trials, Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
National Institute on Drug Abuse, medicine.medical_trial_sponsor.trials_sponsored, Pharmacological Modulation of Cocaine Effects – 1
Interventional, medicine.medical_trial_type.medical_trials, Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children
A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients, medicine.medical_trial.type_of_trial, Interventional
Physicians' Health Study, medicine.medical_trial.type_of_trial, Interventional
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.location, New York
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma, medicine.medical_trial.phase, II
Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children, medicine.medical_trial.type_of_trial, Interventional
A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients, medicine.medical_trial.design, Treatment
Treatment, medicine.medical_trial_design.trials, Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.health_authority, Federal government of the United States
Treatment, medicine.medical_trial_design.trials, A Study of Zidovudine in HIV-Infected Patients With Liver Disease
A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC), medicine.medical_trial.type_of_trial, Interventional
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection, medicine.medical_trial.design, Treatment
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.start_date, 1997-01
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.maximum_age_for_eligibility, 45
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.clinicaltrials_identifier, NCT00000200
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma, medicine.medical_trial.type_of_trial, Interventional
Interventional, medicine.medical_trial_type.medical_trials, Nimotuzumab in Adults With Glioblastoma Multiforma
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.sponsor, National Institute on Drug Abuse
II, medicine.medical_trial_phase.medical_trials, Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4
Treatment, medicine.medical_trial_design.trials, Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up, medicine.medical_trial.type_of_trial, Interventional
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma, medicine.medical_trial.design, Treatment
A Study of Zidovudine in HIV-Infected Patients With Liver Disease, medicine.medical_trial.type_of_trial, Interventional
Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus, medicine.medical_trial.health_authority, Federal government of the United States
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Feasibility Study of Take-Home LAAM Medication – 3
A Study of Zidovudine in HIV-Infected Patients With Liver Disease, medicine.medical_trial.health_authority, Federal government of the United States
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.treatment_being_tested, Methadone
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children
Treatment, medicine.medical_trial_design.trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.phase, II
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.location, Columbia University
Cocaine-Related Disorders, medicine.disease.trials, Pharmacological Modulation of Cocaine Effects – 1
Interventional, medicine.medical_trial_type.medical_trials, Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.sponsor, Columbia University
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.eligibile_genders, Male
Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma, medicine.medical_trial.health_authority, Federal government of the United States
Feasibility Study of Take-Home LAAM Medication – 3, medicine.medical_trial.sponsor, National Institute on Drug Abuse
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.sponsor, National Institute on Drug Abuse
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection, medicine.medical_trial.type_of_trial, Interventional
Treatment, medicine.medical_trial_design.trials, Oral Collagen for Rheumatoid Arthritis
Methadone Effects on Zidovudine (ZDV, AZT) Disposition, medicine.medical_trial.health_authority, Federal government of the United States
Pharmacological Modulation of Cocaine Effects – 1, medicine.medical_trial.type_of_trial, Interventional
II, medicine.medical_trial_phase.medical_trials, Oral Collagen for Rheumatoid Arthritis
A Study of Zidovudine in HIV-Infected Patients With Liver Disease, medicine.medical_trial.design, Treatment
Interventional, medicine.medical_trial_type.medical_trials, Memantine in Systemic Lupus Erythematosus
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Oral Collagen for Rheumatoid Arthritis, medicine.medical_trial.design, Treatment
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Hypertension Prevention Trial (HPT) Feasibility Study
II, medicine.medical_trial_phase.medical_trials, Alendronate and/or Parathyroid Hormone for Osteoporosis
Treatment, medicine.medical_trial_design.trials, Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children
Treatment, medicine.medical_trial_design.trials, The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
Alendronate and/or Parathyroid Hormone for Osteoporosis, medicine.medical_trial.type_of_trial, Interventional
Interventional, medicine.medical_trial_type.medical_trials, Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder
Methadone, medicine.medical_treatment.trials, Cocaine Effects in Humans: Physiology and Behavior – 1
Postmenopausal Hormone Therapy in Unstable Angina, medicine.medical_trial.type_of_trial, Interventional
Interventional, medicine.medical_trial_type.medical_trials, Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections, medicine.medical_trial.design, Treatment
Oral Collagen for Rheumatoid Arthritis, medicine.medical_trial.type_of_trial, Interventional
Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children, medicine.medical_trial.health_authority, Federal government of the United States
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Evaluation of Neuromuscular Disease
Cocaine Effects in Humans: Physiology and Behavior – 1, medicine.medical_trial.expected_total_enrollment, 19
Treatment, medicine.medical_trial_design.trials, Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder
Interventional, medicine.medical_trial_type.medical_trials, The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome, medicine.medical_trial.phase, II
Treatment, medicine.medical_trial_design.trials, Alendronate and/or Parathyroid Hormone for Osteoporosis
Feasibility Study of Take-Home LAAM Medication – 3, medicine.medical_trial.health_authority, Federal government of the United States
Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children, medicine.medical_trial.design, Treatment
Federal government of the United States, medicine.medical_trial_health_authority.medical_trials, Pharmacological Modulation of Cocaine Effects – 1

Answer: Treatment