As a former VPSO, I can tell you that it is a very big deal to law enforcement.  Fully 99+% of my calls were in some way related to alcohol.  We actively sought out bootleggers, and confiscations do occur, especially on felony-level importation.  I know of at least one now-VPSO craft that was foreited by a bootlegger.  

The problem is that for every avenue you shut down, a new one crops up.  Shut down the bootleggers and new ones spring up to fill the void and in the time it takes them to get up and running, someone else is making homebrew.  That's because we have the same underlying problem that made Prohibition fail; the demand is simply strong enough to overpower the enforcement and interdiction efforts against it.  Without creating a totalitarian regieme that breaks the Bill of Rights in more ways that I can count, that won't change.