pt-sk/ml_research_abs huggingface dataset:
Role of Hybrid Deep Neural Networks (HDNNs), Computed Tomography, and Chest X-rays for the Detection of COVID-19.
Authors: MuhammadIrfan, Muhammad AksamIftikhar, SanaYasin, UmarDraz, TariqAli, ShafiqHussain, SarahBukhari, Abdullah SaeedAlwadie, SaifurRahman, AdamGlowacz, FaisalAlthobiani
Journal: International journal of environmental research and public health

COVID-19 syndrome has extensively escalated worldwide with the induction of the year 2020 and has resulted in the illness of millions of people. COVID-19 patients bear an elevated risk once the symptoms deteriorate. Hence, early recognition of diseased patients can facilitate early intervention and avoid disease succession. This article intends to develop a hybrid deep neural networks (HDNNs), using computed tomography (CT) and X-ray imaging, to predict the risk of the onset of disease in patients suffering from COVID-19. To be precise, the subjects were classified into 3 categories namely normal, Pneumonia, and COVID-19. Initially, the CT and chest X-ray images, denoted as 'hybrid images' (with resolution 1080 × 1080) were collected from different sources, including GitHub, COVID-19 radiography database, Kaggle, COVID-19 image data collection, and Actual Med COVID-19 Chest X-ray Dataset, which are open source and publicly available data repositories. The 80% hybrid images were used to train the hybrid deep neural network model and the remaining 20% were used for the testing purpose. The capability and prediction accuracy of the HDNNs were calculated using the confusion matrix. The hybrid deep neural network showed a 99% classification accuracy on the test set data.
Hyperparameter Optimization for COVID-19 Pneumonia Diagnosis Based on Chest CT.
Authors: PauloLacerda, BrunoBarros, CélioAlbuquerque, AuraConci
Journal: Sensors (Basel, Switzerland)

Convolutional Neural Networks (CNNs) have been successfully applied in the medical diagnosis of different types of diseases. However, selecting the architecture and the best set of hyperparameters among the possible combinations can be a significant challenge. The purpose of this work is to investigate the use of the Hyperband optimization algorithm in the process of optimizing a CNN applied to the diagnosis of SARS-Cov2 disease (COVID-19). The test was performed with the Optuna framework, and the optimization process aimed to optimize four hyperparameters: (1) backbone architecture, (2) the number of inception modules, (3) the number of neurons in the fully connected layers, and (4) the learning rate. CNNs were trained on 2175 computed tomography (CT) images. The CNN that was proposed by the optimization process was a VGG16 with five inception modules, 128 neurons in the two fully connected layers, and a learning rate of 0.0027. The proposed method achieved a sensitivity, precision, and accuracy of 97%, 82%, and 88%, outperforming the sensitivity of the Real-Time Polymerase Chain Reaction (RT-PCR) tests (53-88%) and the accuracy of the diagnosis performed by human experts (72%).
COVID-19 Recognition Using Ensemble-CNNs in Two New Chest X-ray Databases.
Authors: EdoardoVantaggiato, EmanuelaPaladini, FaresBougourzi, CosimoDistante, AbdenourHadid, AbdelmalikTaleb-Ahmed
Journal: Sensors (Basel, Switzerland)

The recognition of COVID-19 infection from X-ray images is an emerging field in the learning and computer vision community. Despite the great efforts that have been made in this field since the appearance of COVID-19 (2019), the field still suffers from two drawbacks. First, the number of available X-ray scans labeled as COVID-19-infected is relatively small. Second, all the works that have been carried out in the field are separate; there are no unified data, classes, and evaluation protocols. In this work, based on public and newly collected data, we propose two X-ray COVID-19 databases, which are three-class COVID-19 and five-class COVID-19 datasets. For both databases, we evaluate different deep learning architectures. Moreover, we propose an Ensemble-CNNs approach which outperforms the deep learning architectures and shows promising results in both databases. In other words, our proposed Ensemble-CNNs achieved a high performance in the recognition of COVID-19 infection, resulting in accuracies of 100% and 98.1% in the three-class and five-class scenarios, respectively. In addition, our approach achieved promising results in the overall recognition accuracy of 75.23% and 81.0% for the three-class and five-class scenarios, respectively. We make our databases of COVID-19 X-ray scans publicly available to encourage other researchers to use it as a benchmark for their studies and comparisons.
Volume-of-Interest Aware Deep Neural Networks for Rapid Chest CT-Based COVID-19 Patient Risk Assessment.
Authors: AnargyrosChatzitofis, PierandreaCancian, VasileiosGkitsas, AlessandroCarlucci, PanagiotisStalidis, GeorgiosAlbanis, AntonisKarakottas, TheodorosSemertzidis, PetrosDaras, CaterinaGiannitto, ElenaCasiraghi, Federica MrakicSposta, GiuliaVatteroni, AngelaAmmirabile, LudovicaLofino, PasqualaRagucci, Maria ElenaLaino, AntonioVoza, AntonioDesai, MaurizioCecconi, LucaBalzarini, ArturoChiti, DimitriosZarpalas, VictorSavevski
Journal: International journal of environmental research and public health

Since December 2019, the world has been devastated by the Coronavirus Disease 2019 (COVID-19) pandemic. Emergency Departments have been experiencing situations of urgency where clinical experts, without long experience and mature means in the fight against COVID-19, have to rapidly decide the most proper patient treatment. In this context, we introduce an artificially intelligent tool for effective and efficient Computed Tomography (CT)-based risk assessment to improve treatment and patient care. In this paper, we introduce a data-driven approach built on top of volume-of-interest aware deep neural networks for automatic COVID-19 patient risk assessment (discharged, hospitalized, intensive care unit) based on lung infection quantization through segmentation and, subsequently, CT classification. We tackle the high and varying dimensionality of the CT input by detecting and analyzing only a sub-volume of the CT, the Volume-of-Interest (VoI). Differently from recent strategies that consider infected CT slices without requiring any spatial coherency between them, or use the whole lung volume by applying abrupt and lossy volume down-sampling, we assess only the "most infected volume" composed of slices at its original spatial resolution. To achieve the above, we create, present and publish a new labeled and annotated CT dataset with 626 CT samples from COVID-19 patients. The comparison against such strategies proves the effectiveness of our VoI-based approach. We achieve remarkable performance on patient risk assessment evaluated on balanced data by reaching 88.88%, 89.77%, 94.73% and 88.88% accuracy, sensitivity, specificity and F1-score, respectively.
Exploring the effect of image enhancement techniques on COVID-19 detection using chest X-ray images.
Authors: TawsifurRahman, AmithKhandakar, YazanQiblawey, AnasTahir, SerkanKiranyaz, Saad BinAbul Kashem, Mohammad TariqulIslam, SomayaAl Maadeed, Susu MZughaier, Muhammad SalmanKhan, Muhammad E HChowdhury
Journal: Computers in biology and medicine

Computer-aided diagnosis for the reliable and fast detection of coronavirus disease (COVID-19) has become a necessity to prevent the spread of the virus during the pandemic to ease the burden on the healthcare system. Chest X-ray (CXR) imaging has several advantages over other imaging and detection techniques. Numerous works have been reported on COVID-19 detection from a smaller set of original X-ray images. However, the effect of image enhancement and lung segmentation of a large dataset in COVID-19 detection was not reported in the literature. We have compiled a large X-ray dataset (COVQU) consisting of 18,479 CXR images with 8851 normal, 6012 non-COVID lung infections, and 3616 COVID-19 CXR images and their corresponding ground truth lung masks. To the best of our knowledge, this is the largest public COVID positive database and the lung masks. Five different image enhancement techniques: histogram equalization (HE), contrast limited adaptive histogram equalization (CLAHE), image complement, gamma correction, and balance contrast enhancement technique (BCET) were used to investigate the effect of image enhancement techniques on COVID-19 detection. A novel U-Net model was proposed and compared with the standard U-Net model for lung segmentation. Six different pre-trained Convolutional Neural Networks (CNNs) (ResNet18, ResNet50, ResNet101, InceptionV3, DenseNet201, and ChexNet) and a shallow CNN model were investigated on the plain and segmented lung CXR images. The novel U-Net model showed an accuracy, Intersection over Union (IoU), and Dice coefficient of 98.63%, 94.3%, and 96.94%, respectively for lung segmentation. The gamma correction-based enhancement technique outperforms other techniques in detecting COVID-19 from the plain and the segmented lung CXR images. Classification performance from plain CXR images is slightly better than the segmented lung CXR images; however, the reliability of network performance is significantly improved for the segmented lung images, which was observed using the visualization technique. The accuracy, precision, sensitivity, F1-score, and specificity were 95.11%, 94.55%, 94.56%, 94.53%, and 95.59% respectively for the segmented lung images. The proposed approach with very reliable and comparable performance will boost the fast and robust COVID-19 detection using chest X-ray images.
Semi-supervised learning for an improved diagnosis of COVID-19 in CT images.
Authors: Chang HeeHan, MisukKim, Jin TaeKwak
Journal: PloS one

Coronavirus disease 2019 (COVID-19) has been spread out all over the world. Although a real-time reverse-transcription polymerase chain reaction (RT-PCR) test has been used as a primary diagnostic tool for COVID-19, the utility of CT based diagnostic tools have been suggested to improve the diagnostic accuracy and reliability. Herein we propose a semi-supervised deep neural network for an improved detection of COVID-19. The proposed method utilizes CT images in a supervised and unsupervised manner to improve the accuracy and robustness of COVID-19 diagnosis. Both labeled and unlabeled CT images are employed. Labeled CT images are used for supervised leaning. Unlabeled CT images are utilized for unsupervised learning in a way that the feature representations are invariant to perturbations in CT images. To systematically evaluate the proposed method, two COVID-19 CT datasets and three public CT datasets with no COVID-19 CT images are employed. In distinguishing COVID-19 from non-COVID-19 CT images, the proposed method achieves an overall accuracy of 99.83%, sensitivity of 0.9286, specificity of 0.9832, and positive predictive value (PPV) of 0.9192. The results are consistent between the COVID-19 challenge dataset and the public CT datasets. For discriminating between COVID-19 and common pneumonia CT images, the proposed method obtains 97.32% accuracy, 0.9971 sensitivity, 0.9598 specificity, and 0.9326 PPV. Moreover, the comparative experiments with respect to supervised learning and training strategies demonstrate that the proposed method is able to improve the diagnostic accuracy and robustness without exhaustive labeling. The proposed semi-supervised method, exploiting both supervised and unsupervised learning, facilitates an accurate and reliable diagnosis for COVID-19, leading to an improved patient care and management.
Automated Detection of COVID-19 Cases on Radiographs using Shape-Dependent Fibonacci-p Patterns.
Authors: KarenPanetta, ForamSanghavi, SosAgaian, NeelMadan
Journal: IEEE journal of biomedical and health informatics

The coronavirus (COVID-19) pandemic has been adversely affecting people's health globally. To diminish the effect of this widespread pandemic, it is essential to detect COVID-19 cases as quickly as possible. Chest radiographs are less expensive and are a widely available imaging modality for detecting chest pathology compared with CT images. They play a vital role in early prediction and developing treatment plans for suspected or confirmed COVID-19 chest infection patients. In this paper, a novel shape-dependent Fibonacci-p patterns-based feature descriptor using a machine learning approach is proposed. Computer simulations show that the presented system (1) increases the effectiveness of differentiating COVID-19, viral pneumonia, and normal conditions, (2) is effective on small datasets, and (3) has faster inference time compared to deep learning methods with comparable performance. Computer simulations are performed on two publicly available datasets; (a) the Kaggle dataset, and (b) the COVIDGR dataset. To assess the performance of the presented system, various evaluation parameters, such as accuracy, recall, specificity, precision, and f1-score are used. Nearly 100% differentiation between normal and COVID-19 radiographs is observed for the three-class classification scheme using the lung area-specific Kaggle radiographs. While Recall of 72.65 ± 6.83 and specificity of 77.72 ± 8.06 is observed for the COVIDGR dataset.
Federated deep learning for detecting COVID-19 lung abnormalities in CT: a privacy-preserving multinational validation study.
Authors: QiDou, Tiffany YSo, MeiruiJiang, QuandeLiu, VarutVardhanabhuti, GeorgiosKaissis, ZejuLi, WeixinSi, Heather H CLee, KevinYu, ZuxinFeng, LiDong, EgonBurian, FriederikeJungmann, RickmerBraren, MarcusMakowski, BernhardKainz, DanielRueckert, BenGlocker, Simon C HYu, Pheng AnnHeng
Journal: NPJ digital medicine

Data privacy mechanisms are essential for rapidly scaling medical training databases to capture the heterogeneity of patient data distributions toward robust and generalizable machine learning systems. In the current COVID-19 pandemic, a major focus of artificial intelligence (AI) is interpreting chest CT, which can be readily used in the assessment and management of the disease. This paper demonstrates the feasibility of a federated learning method for detecting COVID-19 related CT abnormalities with external validation on patients from a multinational study. We recruited 132 patients from seven multinational different centers, with three internal hospitals from Hong Kong for training and testing, and four external, independent datasets from Mainland China and Germany, for validating model generalizability. We also conducted case studies on longitudinal scans for automated estimation of lesion burden for hospitalized COVID-19 patients. We explore the federated learning algorithms to develop a privacy-preserving AI model for COVID-19 medical image diagnosis with good generalization capability on unseen multinational datasets. Federated learning could provide an effective mechanism during pandemics to rapidly develop clinically useful AI across institutions and countries overcoming the burden of central aggregation of large amounts of sensitive data.
Deep learning for diagnosis of COVID-19 using 3D CT scans.
Authors: SertanSerte, HasanDemirel
Journal: Computers in biology and medicine

A new pneumonia-type coronavirus, COVID-19, recently emerged in Wuhan, China. COVID-19 has subsequently infected many people and caused many deaths worldwide. Isolating infected people is one of the methods of preventing the spread of this virus. CT scans provide detailed imaging of the lungs and assist radiologists in diagnosing COVID-19 in hospitals. However, a person's CT scan contains hundreds of slides, and the diagnosis of COVID-19 using such scans can lead to delays in hospitals. Artificial intelligence techniques could assist radiologists with rapidly and accurately detecting COVID-19 infection from these scans. This paper proposes an artificial intelligence (AI) approach to classify COVID-19 and normal CT volumes. The proposed AI method uses the ResNet-50 deep learning model to predict COVID-19 on each CT image of a 3D CT scan. Then, this AI method fuses image-level predictions to diagnose COVID-19 on a 3D CT volume. We show that the proposed deep learning model provides 96% AUC value for detecting COVID-19 on CT scans.
Serial Quantitative Chest CT Assessment of COVID-19: A Deep Learning Approach.
Authors: LuHuang, RuiHan, TaoAi, PengxinYu, HanKang, QianTao, LimingXia
Journal: Radiology. Cardiothoracic imaging

To quantitatively evaluate lung burden changes in patients with coronavirus disease 2019 (COVID-19) by using serial CT scan by an automated deep learning method.
Patients with COVID-19, who underwent chest CT between January 1 and February 3, 2020, were retrospectively evaluated. The patients were divided into mild, moderate, severe, and critical types, according to their baseline clinical, laboratory, and CT findings. CT lung opacification percentages of the whole lung and five lobes were automatically quantified by a commercial deep learning software and compared with those at follow-up CT scans. Longitudinal changes of the CT quantitative parameter were also compared among the four clinical types.
A total of 126 patients with COVID-19 (mean age, 52 years ± 15 [standard deviation]; 53.2% males) were evaluated, including six mild, 94 moderate, 20 severe, and six critical cases. CT-derived opacification percentage was significantly different among clinical groups at baseline, gradually progressing from mild to critical type (all 
The quantification of lung opacification in COVID-19 measured at chest CT by using a commercially available deep learning-based tool was significantly different among groups with different clinical severity. This approach could potentially eliminate the subjectivity in the initial assessment and follow-up of pulmonary findings in COVID-19.
Deep-chest: Multi-classification deep learning model for diagnosing COVID-19, pneumonia, and lung cancer chest diseases.
Authors: Dina MIbrahim, Nada MElshennawy, Amany MSarhan
Journal: Computers in biology and medicine

Corona Virus Disease (COVID-19) has been announced as a pandemic and is spreading rapidly throughout the world. Early detection of COVID-19 may protect many infected people. Unfortunately, COVID-19 can be mistakenly diagnosed as pneumonia or lung cancer, which with fast spread in the chest cells, can lead to patient death. The most commonly used diagnosis methods for these three diseases are chest X-ray and computed tomography (CT) images. In this paper, a multi-classification deep learning model for diagnosing COVID-19, pneumonia, and lung cancer from a combination of chest x-ray and CT images is proposed. This combination has been used because chest X-ray is less powerful in the early stages of the disease, while a CT scan of the chest is useful even before symptoms appear, and CT can precisely detect the abnormal features that are identified in images. In addition, using these two types of images will increase the dataset size, which will increase the classification accuracy. To the best of our knowledge, no other deep learning model choosing between these diseases is found in the literature. In the present work, the performance of four architectures are considered, namely: VGG19-CNN, ResNet152V2, ResNet152V2 + Gated Recurrent Unit (GRU), and ResNet152V2 + Bidirectional GRU (Bi-GRU). A comprehensive evaluation of different deep learning architectures is provided using public digital chest x-ray and CT datasets with four classes (i.e., Normal, COVID-19, Pneumonia, and Lung cancer). From the results of the experiments, it was found that the VGG19 +CNN model outperforms the three other proposed models. The VGG19+CNN model achieved 98.05% accuracy (ACC), 98.05% recall, 98.43% precision, 99.5% specificity (SPC), 99.3% negative predictive value (NPV), 98.24% F1 score, 97.7% Matthew's correlation coefficient (MCC), and 99.66% area under the curve (AUC) based on X-ray and CT images.
COVID-19 in CXR: From Detection and Severity Scoring to Patient Disease Monitoring.
Authors: MaayanFrid-Adar, RulaAmer, OphirGozes, JannetteNassar, HayitGreenspan
Journal: IEEE journal of biomedical and health informatics

This work estimates the severity of pneumonia in COVID-19 patients and reports the findings of a longitudinal study of disease progression. It presents a deep learning model for simultaneous detection and localization of pneumonia in chest Xray (CXR) images, which is shown to generalize to COVID-19 pneumonia. The localization maps are utilized to calculate a "Pneumonia Ratio" which indicates disease severity. The assessment of disease severity serves to build a temporal disease extent profile for hospitalized patients. To validate the model's applicability to the patient monitoring task, we developed a validation strategy which involves a synthesis of Digital Reconstructed Radiographs (DRRs - synthetic Xray) from serial CT scans; we then compared the disease progression profiles that were generated from the DRRs to those that were generated from CT volumes.
Generalized chest CT and lab curves throughout the course of COVID-19.
Authors: Michael TKassin, NicoleVarble, MaximeBlain, ShengXu, Evrim BTurkbey, StephanieHarmon, DongYang, ZiyueXu, HolgerRoth, DaguangXu, MonaFlores, AmelAmalou, KaiyunSun, SameerKadri, FrancescaPatella, MaurizioCariati, AliceScarabelli, ElviraStellato, Anna MariaIerardi, GianpaoloCarrafiello, PengAn, BarisTurkbey, Bradford JWood
Journal: Scientific reports

A better understanding of temporal relationships between chest CT and labs may provide a reference for disease severity over the disease course. Generalized curves of lung opacity volume and density over time can be used as standardized references from well before symptoms develop to over a month after recovery, when residual lung opacities remain. 739 patients with COVID-19 underwent CT and RT-PCR in an outbreak setting between January 21st and April 12th, 2020. 29 of 739 patients had serial exams (121 CTs and 279 laboratory measurements) over 50 ± 16 days, with an average of 4.2 sequential CTs each. Sequential volumes of total lung, overall opacity and opacity subtypes (ground glass opacity [GGO] and consolidation) were extracted using deep learning and manual segmentation. Generalized temporal curves of CT and laboratory measurements were correlated. Lung opacities appeared 3.4 ± 2.2 days prior to symptom onset. Opacity peaked 1 day after symptom onset. GGO onset was earlier and resolved later than consolidation. Lactate dehydrogenase, and C-reactive protein peaked earlier than procalcitonin and leukopenia. The temporal relationships of quantitative CT features and clinical labs have distinctive patterns and peaks in relation to symptom onset, which may inform early clinical course in patients with mild COVID-19 pneumonia, or may shed light upon chronic lung effects or mechanisms of medical countermeasures in clinical trials.
Metaheuristic-based Deep COVID-19 Screening Model from Chest X-Ray Images.
Authors: ManjitKaur, VijayKumar, VaishaliYadav, DilbagSingh, NareshKumar, Nripendra NarayanDas
Journal: Journal of healthcare engineering

COVID-19 has affected the whole world drastically. A huge number of people have lost their lives due to this pandemic. Early detection of COVID-19 infection is helpful for treatment and quarantine. Therefore, many researchers have designed a deep learning model for the early diagnosis of COVID-19-infected patients. However, deep learning models suffer from overfitting and hyperparameter-tuning issues. To overcome these issues, in this paper, a metaheuristic-based deep COVID-19 screening model is proposed for X-ray images. The modified AlexNet architecture is used for feature extraction and classification of the input images. Strength Pareto evolutionary algorithm-II (SPEA-II) is used to tune the hyperparameters of modified AlexNet. The proposed model is tested on a four-class (i.e., COVID-19, tuberculosis, pneumonia, or healthy) dataset. Finally, the comparisons are drawn among the existing and the proposed models.