pt-sk/ml_research_abs huggingface dataset:
CXR-Net: A Multitask Deep Learning Network for Explainable and Accurate Diagnosis of COVID-19 Pneumonia From Chest X-Ray Images.
Authors: XinZhang, LiangxiuHan, TamSobeih, LianghaoHan, NinaDempsey, SymeonLechareas, AscanioTridente, HaomingChen, StephenWhite, DaoqiangZhang
Journal: IEEE journal of biomedical and health informatics

Accurate and rapid detection of COVID-19 pneumonia is crucial for optimal patient treatment. Chest X-Ray (CXR) is the first-line imaging technique for COVID-19 pneumonia diagnosis as it is fast, cheap and easily accessible. Currently, many deep learning (DL) models have been proposed to detect COVID-19 pneumonia from CXR images. Unfortunately, these deep classifiers lack the transparency in interpreting findings, which may limit their applications in clinical practice. The existing explanation methods produce either too noisy or imprecise results, and hence are unsuitable for diagnostic purposes. In this work, we propose a novel explainable CXR deep neural Network (CXR-Net) for accurate COVID-19 pneumonia detection with an enhanced pixel-level visual explanation using CXR images. An Encoder-Decoder-Encoder architecture is proposed, in which an extra encoder is added after the encoder-decoder structure to ensure the model can be trained on category samples. The method has been evaluated on real world CXR datasets from both public and private sources, including healthy, bacterial pneumonia, viral pneumonia and COVID-19 pneumonia cases. The results demonstrate that the proposed method can achieve a satisfactory accuracy and provide fine-resolution activation maps for visual explanation in the lung disease detection. Compared to current state-of-the-art visual explanation methods, the proposed method can provide more detailed, high-resolution, visual explanation for the classification results. It can be deployed in various computing environments, including cloud, CPU and GPU environments. It has a great potential to be used in clinical practice for COVID-19 pneumonia diagnosis.
Strong semantic segmentation for Covid-19 detection: Evaluating the use of deep learning models as a performant tool in radiography.
Authors: HAllioui, YMourdi, MSadgal
Journal: Radiography (London, England : 1995)

With the increasing number of Covid-19 cases as well as care costs, chest diseases have gained increasing interest in several communities, particularly in medical and computer vision. Clinical and analytical exams are widely recognized techniques for diagnosing and handling Covid-19 cases. However, strong detection tools can help avoid damage to chest tissues. The proposed method provides an important way to enhance the semantic segmentation process using combined potential deep learning (DL) modules to increase consistency. Based on Covid-19 CT images, this work hypothesized that a novel model for semantic segmentation might be able to extract definite graphical features of Covid-19 and afford an accurate clinical diagnosis while optimizing the classical test and saving time.
CT images were collected considering different cases (normal chest CT, pneumonia, typical viral causes, and Covid-19 cases). The study presents an advanced DL method to deal with chest semantic segmentation issues. The approach employs a modified version of the U-net to enable and support Covid-19 detection from the studied images.
The validation tests demonstrated competitive results with important performance rates: Precision (90.96% ± 2.5) with an F-score of (91.08% ± 3.2), an accuracy of (93.37% ± 1.2), a sensitivity of (96.88% ± 2.8) and a specificity of (96.91% ± 2.3). In addition, the visual segmentation results are very close to the Ground truth.
The findings of this study reveal the proof-of-principle for using cooperative components to strengthen the semantic segmentation modules for effective and truthful Covid-19 diagnosis.
This paper has highlighted that DL based approach, with several modules, may be contributing to provide strong support for radiographers and physicians, and that further use of DL is required to design and implement performant automated vision systems to detect chest diseases.
Contrastive domain adaptation with consistency match for automated pneumonia diagnosis.
Authors: YangqinFeng, ZizhouWang, XinxingXu, YanWang, HuazhuFu, ShaohuaLi, LiangliZhen, XiaofengLei, YingnanCui, JordanSim Zheng Ting, YonghanTing, Joey TianyiZhou, YongLiu, RickSiow Mong Goh, CherHeng Tan
Journal: Medical image analysis

Pneumonia can be difficult to diagnose since its symptoms are too variable, and the radiographic signs are often very similar to those seen in other illnesses such as a cold or influenza. Deep neural networks have shown promising performance in automated pneumonia diagnosis using chest X-ray radiography, allowing mass screening and early intervention to reduce the severe cases and death toll. However, they usually require many well-labelled chest X-ray images for training to achieve high diagnostic accuracy. To reduce the need for training data and annotation resources, we propose a novel method called Contrastive Domain Adaptation with Consistency Match (CDACM). It transfers the knowledge from different but relevant datasets to the unlabelled small-size target dataset and improves the semantic quality of the learnt representations. Specifically, we design a conditional domain adversarial network to exploit discriminative information conveyed in the predictions to mitigate the domain gap between the source and target datasets. Furthermore, due to the small scale of the target dataset, we construct a feature cloud for each target sample and leverage contrastive learning to extract more discriminative features. Lastly, we propose adaptive feature cloud expansion to push the decision boundary to a low-density area. Unlike most existing transfer learning methods that aim only to mitigate the domain gap, our method instead simultaneously considers the domain gap and the data deficiency problem of the target dataset. The conditional domain adaptation and the feature cloud generation of our method are learning jointly to extract discriminative features in an end-to-end manner. Besides, the adaptive feature cloud expansion improves the model's generalisation ability in the target domain. Extensive experiments on pneumonia and COVID-19 diagnosis tasks demonstrate that our method outperforms several state-of-the-art unsupervised domain adaptation approaches, which verifies the effectiveness of CDACM for automated pneumonia diagnosis using chest X-ray imaging.
Assessment of COVID-19 lung involvement on computed tomography by deep-learning-, threshold-, and human reader-based approaches-an international, multi-center comparative study.
Authors: PhilippFervers, FlorianFervers, AsthaJaiswal, MiriamRinneburger, MathildaWeisthoff, PhilipPollmann-Schweckhorst, JonathanKottlors, HeikeCarolus, SimonLennartz, DavidMaintz, RahilShahzad, ThorstenPersigehl
Journal: Quantitative imaging in medicine and surgery

The extent of lung involvement in coronavirus disease 2019 (COVID-19) pneumonia, quantified on computed tomography (CT), is an established biomarker for prognosis and guides clinical decision-making. The clinical standard is semi-quantitative scoring of lung involvement by an experienced reader. We aim to compare the performance of automated deep-learning- and threshold-based methods to the manual semi-quantitative lung scoring. Further, we aim to investigate an optimal threshold for quantification of involved lung in COVID pneumonia chest CT, using a multi-center dataset.
In total 250 patients were included, 50 consecutive patients with RT-PCR confirmed COVID-19 from our local institutional database, and another 200 patients from four international datasets (n=50 each). Lung involvement was scored semi-quantitatively by three experienced radiologists according to the established chest CT score (CCS) ranging from 0-25. Inter-rater reliability was reported by the intraclass correlation coefficient (ICC). Deep-learning-based segmentation of ground-glass and consolidation was obtained by CT Pulmo Auto Results prototype plugin on IntelliSpace Discovery (Philips Healthcare, The Netherlands). Threshold-based segmentation of involved lung was implemented using an open-source tool for whole-lung segmentation under the presence of severe pathologies (R231CovidWeb, Hofmanninger 
Median CCS among 250 evaluated patients was 10 [6-15]. Inter-rater reliability of the CCS was excellent [ICC 0.97 (0.97-0.98)]. Best attenuation threshold for identification of involved lung was -522 HU. While the relationship of deep-learning- and threshold-based quantification was linear and strong (r
The manual semi-quantitative CCS underestimates the extent of COVID pneumonia in higher score ranges, which limits its clinical usefulness in cases of severe disease. Clinical implementation of fully automated methods, such as deep-learning or threshold-based approaches (best threshold in our multi-center dataset: -522 HU), might save time of trained personnel, abolish inter-reader variability, and allow for truly quantitative, linear assessment of COVID lung involvement.
A novel deep learning-based method for COVID-19 pneumonia detection from CT images.
Authors: JuLuo, YuhaoSun, JingshuChi, XinLiao, CanxiaXu
Journal: BMC medical informatics and decision making

The sensitivity of RT-PCR in diagnosing COVID-19 is only 60-70%, and chest CT plays an indispensable role in the auxiliary diagnosis of COVID-19 pneumonia, but the results of CT imaging are highly dependent on professional radiologists.
This study aimed to develop a deep learning model to assist radiologists in detecting COVID-19 pneumonia.
The total study population was 437. The training dataset contained 26,477, 2468, and 8104 CT images of normal, CAP, and COVID-19, respectively. The validation dataset contained 14,076, 1028, and 3376 CT images of normal, CAP, and COVID-19 patients, respectively. The test set included 51 normal cases, 28 CAP patients, and 51 COVID-19 patients. We designed and trained a deep learning model to recognize normal, CAP, and COVID-19 patients based on U-Net and ResNet-50. Moreover, the diagnoses of the deep learning model were compared with different levels of radiologists.
In the test set, the sensitivity of the deep learning model in diagnosing normal cases, CAP, and COVID-19 patients was 98.03%, 89.28%, and 92.15%, respectively. The diagnostic accuracy of the deep learning model was 93.84%. In the validation set, the accuracy was 92.86%, which was better than that of two novice doctors (86.73% and 87.75%) and almost equal to that of two experts (94.90% and 93.88%). The AI model performed significantly better than all four radiologists in terms of time consumption (35 min vs. 75 min, 93 min, 79 min, and 82 min).
The AI model we obtained had strong decision-making ability, which could potentially assist doctors in detecting COVID-19 pneumonia.
Towards smart diagnostic methods for COVID-19: Review of deep learning for medical imaging.
Authors: MarjanJalali Moghaddam, MinaGhavipour
Journal: IPEM-translation

The infectious disease known as COVID-19 has spread dramatically all over the world since December 2019. The fast diagnosis and isolation of infected patients are key factors in slowing down the spread of this virus and better management of the pandemic. Although the CT and X-ray modalities are commonly used for the diagnosis of COVID-19, identifying COVID-19 patients from medical images is a time-consuming and error-prone task. Artificial intelligence has shown to have great potential to speed up and optimize the prognosis and diagnosis process of COVID-19. Herein, we review publications on the application of deep learning (DL) techniques for diagnostics of patients with COVID-19 using CT and X-ray chest images for a period from January 2020 to October 2021. Our review focuses solely on peer-reviewed, well-documented articles. It provides a comprehensive summary of the technical details of models developed in these articles and discusses the challenges in the smart diagnosis of COVID-19 using DL techniques. Based on these challenges, it seems that the effectiveness of the developed models in clinical use needs to be further investigated. This review provides some recommendations to help researchers develop more accurate prediction models.
A deep transfer learning-based convolution neural network model for COVID-19 detection using computed tomography scan images for medical applications.
Authors: Nirmala DeviKathamuthu, ShanthiSubramaniam, Quynh HoangLe, SureshMuthusamy, HiteshPanchal, Suma Christal MarySundararajan, Ali JawadAlrubaie, Musaddak Maher AbdulZahra
Journal: Advances in engineering software (Barking, London, England : 1992)

The Coronavirus (COVID-19) has become a critical and extreme epidemic because of its international dissemination. COVID-19 is the world's most serious health, economic, and survival danger. This disease affects not only a single country but the entire planet due to this infectious disease. Illnesses of Covid-19 spread at a much faster rate than usual influenza cases. Because of its high transmissibility and early diagnosis, it isn't easy to manage COVID-19. The popularly used RT-PCR method for COVID-19 disease diagnosis may provide false negatives. COVID-19 can be detected non-invasively using medical imaging procedures such as chest CT and chest x-ray. Deep learning is the most effective machine learning approach for examining a considerable quantity of chest computed tomography (CT) pictures that can significantly affect Covid-19 screening. Convolutional neural network (CNN) is one of the most popular deep learning techniques right now, and its gaining traction due to its potential to transform several spheres of human life. This research aims to develop conceptual transfer learning enhanced CNN framework models for detecting COVID-19 with CT scan images. Though with minimal datasets, these techniques were demonstrated to be effective in detecting the presence of COVID-19. This proposed research looks into several deep transfer learning-based CNN approaches for detecting the presence of COVID-19 in chest CT images.VGG16, VGG19, Densenet121, InceptionV3, Xception, and Resnet50 are the foundation models used in this work. Each model's performance was evaluated using a confusion matrix and various performance measures such as accuracy, recall, precision, f1-score, loss, and ROC. The VGG16 model performed much better than the other models in this study (98.00 % accuracy). Promising outcomes from experiments have revealed the merits of the proposed model for detecting and monitoring COVID-19 patients. This could help practitioners and academics create a tool to help minimal health professionals decide on the best course of therapy.
A robust semantic lung segmentation study for CNN-based COVID-19 diagnosis.
Authors: Muhammet FatihAslan
Journal: Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society

This paper aims to diagnose COVID-19 by using Chest X-Ray (CXR) scan images in a deep learning-based system. First of all, COVID-19 Chest X-Ray Dataset is used to segment the lung parts in CXR images semantically. DeepLabV3+ architecture is trained by using the masks of the lung parts in this dataset. The trained architecture is then fed with images in the COVID-19 Radiography Database. In order to improve the output images, some image preprocessing steps are applied. As a result, lung regions are successfully segmented from CXR images. The next step is feature extraction and classification. While features are extracted with modified AlexNet (mAlexNet), Support Vector Machine (SVM) is used for classification. As a result, 3-class data consisting of Normal, Viral Pneumonia and COVID-19 class are classified with 99.8% success. Classification results show that the proposed method is superior to previous state-of-the-art methods.
Deep-learning-based hepatic fat assessment (DeHFt) on non-contrast chest CT and its association with disease severity in COVID-19 infections: A multi-site retrospective study.
Authors: GouravModanwal, SadeerAl-Kindi, JonathanWalker, RohanDhamdhere, LeiYuan, MengyaoJi, ChengLu, PingfuFu, SanjayRajagopalan, AnantMadabhushi
Journal: EBioMedicine

Hepatic steatosis (HS) identified on CT may provide an integrated cardiometabolic and COVID-19 risk assessment. This study presents a deep-learning-based hepatic fat assessment (DeHFt) pipeline for (a) more standardised measurements and (b) investigating the association between HS (liver-to-spleen attenuation ratio <1 in CT) and COVID-19 infections severity, wherein severity is defined as requiring invasive mechanical ventilation, extracorporeal membrane oxygenation, death.
DeHFt comprises two steps. First, a deep-learning-based segmentation model (3D residual-UNet) is trained (N.ß=.ß80) to segment the liver and spleen. Second, CT attenuation is estimated using slice-based and volumetric-based methods. DeHFt-based mean liver and liver-to-spleen attenuation are compared with an expert's ROI-based measurements. We further obtained the liver-to-spleen attenuation ratio in a large multi-site cohort of patients with COVID-19 infections (D1, N.ß=.ß805; D2, N.ß=.ß1917; D3, N.ß=.ß169) using the DeHFt pipeline and investigated the association between HS and COVID-19 infections severity.
The DeHFt pipeline achieved a dice coefficient of 0.95, 95% CI [0.93...0.96] on the independent validation cohort (N.ß=.ß49). The automated slice-based and volumetric-based liver and liver-to-spleen attenuation estimations strongly correlated with expert's measurement. In the COVID-19 cohorts, severe infections had a higher proportion of patients with HS than non-severe infections (pooled OR.ß=.ß1.50, 95% CI [1.20...1.88], P.ß<.ß.001).
The DeHFt pipeline enabled accurate segmentation of liver and spleen on non-contrast CTs and automated estimation of liver and liver-to-spleen attenuation ratio. In three cohorts of patients with COVID-19 infections (N.ß=.ß2891), HS was associated with disease severity. Pending validation, DeHFt provides an automated CT-based metabolic risk assessment.
For a full list of funding bodies, please see the Acknowledgements.
Artificial Intelligence and Deep Learning Assisted Rapid Diagnosis of COVID-19 from Chest Radiographical Images: A Survey.
Authors: DeepakSinwar, Vijaypal SinghDhaka, Biniyam AlemuTesfaye, GhanshyamRaghuwanshi, AshishKumar, Sunil KrMaakar, SanjayAgrawal
Journal: Contrast media & molecular imaging

Artificial Intelligence (AI) has been applied successfully in many real-life domains for solving complex problems. With the invention of Machine Learning (ML) paradigms, it becomes convenient for researchers to predict the outcome based on past data. Nowadays, ML is acting as the biggest weapon against the COVID-19 pandemic by detecting symptomatic cases at an early stage and warning people about its futuristic effects. It is observed that COVID-19 has blown out globally so much in a short period because of the shortage of testing facilities and delays in test reports. To address this challenge, AI can be effectively applied to produce fast as well as cost-effective solutions. Plenty of researchers come up with AI-based solutions for preliminary diagnosis using chest CT Images, respiratory sound analysis, voice analysis of symptomatic persons with asymptomatic ones, and so forth. Some AI-based applications claim good accuracy in predicting the chances of being COVID-19-positive. Within a short period, plenty of research work is published regarding the identification of COVID-19. This paper has carefully examined and presented a comprehensive survey of more than 110 papers that came from various reputed sources, that is, Springer, IEEE, Elsevier, MDPI, arXiv, and medRxiv. Most of the papers selected for this survey presented candid work to detect and classify COVID-19, using deep-learning-based models from chest X-Rays and CT scan images. We hope that this survey covers most of the work and provides insights to the research community in proposing efficient as well as accurate solutions for fighting the pandemic.
A CNN-transformer fusion network for COVID-19 CXR image classification.
Authors: KaiCao, TaoDeng, ChuanlinZhang, LimengLu, LinLi
Journal: PloS one

The global health crisis due to the fast spread of coronavirus disease (Covid-19) has caused great danger to all aspects of healthcare, economy, and other aspects. The highly infectious and insidious nature of the new coronavirus greatly increases the difficulty of outbreak prevention and control. The early and rapid detection of Covid-19 is an effective way to reduce the spread of Covid-19. However, detecting Covid-19 accurately and quickly in large populations remains to be a major challenge worldwide. In this study, A CNN-transformer fusion framework is proposed for the automatic classification of pneumonia on chest X-ray. This framework includes two parts: data processing and image classification. The data processing stage is to eliminate the differences between data from different medical institutions so that they have the same storage format; in the image classification stage, we use a multi-branch network with a custom convolution module and a transformer module, including feature extraction, feature focus, and feature classification sub-networks. Feature extraction subnetworks extract the shallow features of the image and interact with the information through the convolution and transformer modules. Both the local and global features are extracted by the convolution module and transformer module of feature-focus subnetworks, and are classified by the feature classification subnetworks. The proposed network could decide whether or not a patient has pneumonia, and differentiate between Covid-19 and bacterial pneumonia. This network was implemented on the collected benchmark datasets and the result shows that accuracy, precision, recall, and F1 score are 97.09%, 97.16%, 96.93%, and 97.04%, respectively. Our network was compared with other researchers' proposed methods and achieved better results in terms of accuracy, precision, and F1 score, proving that it is superior for Covid-19 detection. With further improvements to this network, we hope that it will provide doctors with an effective tool for diagnosing Covid-19.
Classification and Detection of COVID-19 and Other Chest-Related Diseases Using Transfer Learning.
Authors: Muhammad TahirNaseem, TajmalHussain, Chan-SuLee, Muhammad AdnanKhan
Journal: Sensors (Basel, Switzerland)

COVID-19 has infected millions of people worldwide over the past few years. The main technique used for COVID-19 detection is reverse transcription, which is expensive, sensitive, and requires medical expertise. X-ray imaging is an alternative and more accessible technique. This study aimed to improve detection accuracy to create a computer-aided diagnostic tool. Combining other artificial intelligence applications techniques with radiological imaging can help detect different diseases. This study proposes a technique for the automatic detection of COVID-19 and other chest-related diseases using digital chest X-ray images of suspected patients by applying transfer learning (TL) algorithms. For this purpose, two balanced datasets, Dataset-1 and Dataset-2, were created by combining four public databases and collecting images from recently published articles. Dataset-1 consisted of 6000 chest X-ray images with 1500 for each class. Dataset-2 consisted of 7200 images with 1200 for each class. To train and test the model, TL with nine pretrained convolutional neural networks (CNNs) was used with augmentation as a preprocessing method. The network was trained to classify using five classifiers: two-class classifier (normal and COVID-19); three-class classifier (normal, COVID-19, and viral pneumonia), four-class classifier (normal, viral pneumonia, COVID-19, and tuberculosis (Tb)), five-class classifier (normal, bacterial pneumonia, COVID-19, Tb, and pneumothorax), and six-class classifier (normal, bacterial pneumonia, COVID-19, viral pneumonia, Tb, and pneumothorax). For two, three, four, five, and six classes, our model achieved a maximum accuracy of 99.83, 98.11, 97.00, 94.66, and 87.29%, respectively.