In this task, you are given a question and a context passage. You have to answer the question based on the given passage.

[Q]: what is the second time period mentioned?, Context: European colonialism in the Sahara began in the 19th century. France conquered the regency of Algiers from the Ottomans in 1830, and French rule spread south from Algeria and eastwards from Senegal into the upper Niger to include present-day Algeria, Chad, Mali then French Sudan including Timbuktu, Mauritania, Morocco (1912), Niger, and Tunisia (1881). By the beginning of the 20th century, the trans-Saharan trade had clearly declined because goods were moved through more modern and efficient means, such as airplanes, rather than across the desert.
[A]: 1830

[Q]: What posthumous service did Lowe perform on Whitehead's behalf?, Context: The two volume biography of Whitehead by Victor Lowe is the most definitive presentation of the life of Whitehead. However, many details of Whitehead's life remain obscure because he left no Nachlass; his family carried out his instructions that all of his papers be destroyed after his death. Additionally, Whitehead was known for his "almost fanatical belief in the right to privacy", and for writing very few personal letters of the kind that would help to gain insight on his life. This led to Lowe himself remarking on the first page of Whitehead's biography, "No professional biographer in his right mind would touch him."
[A]: biography

[Q]: What can cause resistance to more than one antibacterial?, Context: Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
[A]:
Plasmids that carry several different resistance genes