Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Q: Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth.', 'To study the inflammatory, structural and functional effects of caffeine in an animal model of BPD.', 'Preterm New Zealand-Dendermonde rabbits (gestational day 28; term 31) were randomized to three groups: normoxia-placebo (N-P), hyperoxia-placebo (H-P) and hyperoxia-caffeine (H-C). Lung function was assessed on postnatal day 5, along with airway morphometry, vascular morphometry and a score observing airway inflammation.', 'Caffeine improved lung function by increasing lung volume [mean displaced volume N-P: 40.1 6 ml/kg, H-P: 27.8 8 ml/kg and H-C: 34.4 7 ml/kg (p < 0.05); total lung capacity: N-P: 1.17 0.1 ml, H-P: 0.67 0.1 ml and H-C: 1.1 0.1 ml (p < 0.05)], decreasing tissue damping [N-P: 2.7 0.3 cm H2O/ml, H-P: 4.6 0.6 cm H2O/ml and H-C: 3.2 0.4 cm H2O/ml (p < 0.05)], elastance [N-P: 9.3 2.4 cm H2O/ml, H-P: 19.2 7.4 cm H2O/ml and H-C: 10.7 2 cm H2O/ml (p < 0.05)] and compliance [N-P: 0.06 0.01 cm H2O/ml, H-P: 0.054 0.01 cm H2O/ml and H-C: 0.07 0.013 cm H2O/ml (p < 0.05)]. Caffeine also improved histology by decreasing alveolar size [linear intercepts; N-P: 83.6 1.7, H-P: 82.9 1.6 and H-C: 67.3 1.4 (p < 0.05)], increasing radial alveolar count (N-P: 6.6 0.5, H-P: 5.7 0.6 and H-C: 7.05 0.5) and decreasing the acute inflammation score [N-P: 0.3 0.1, H-P: 0.5 0.1 and H-C: 0.4 0.1 (p < 0.05)].
A:
Does caffeine prevent Hyperoxia-Induced Functional and Structural Lung Damage in Preterm Rabbits?