Given the task definition and input, reply with output. Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

Context: Beta2-glycoprotein I (2GPI) is a highly abundant glycoprotein in plasma. Our previous study demonstrated strong 2GPI expression in hepatitis B-related hepatocellular carcinoma (HCC) tissue and the combination of 2GPI and hepatitis B surface antigen (HBsAg) was shown to significantly activate the nuclear factor kappa B (NF-B). To investigate whether lipopolysaccharide (LPS) enhances 2GPI activation of NF-B and the expression of downstream factors (e.g., tumor necrosis factor alpha, TNF-; interleukin-1 beta, IL-1; alpha-fetoprotein, AFP) in the human hepatoma cell line, SMMC-7721.', 'Experimental samples were divided into 4 groups as follows: Group A--blank cell group (SMMC-7721); group B--low, medium, and high LPS concentration groups (1 ng/mL; 10 ng/mL; and 100 ng/mL, respectively); group C--2GPI transfected group; and group D--2GPI + low, medium, or high concentrations from the LPS affected group. Activation of NF-B was evaluated using laser scanning confocal microscopy. Expression of downstream factors was measured by ELISA.', 'Degrees of NF-B activation in groups B, C, and D were varied. NF-B activation in group D was the most significant, and the expressions of downstream factors, TNF- and IL-1, were the highest level of activation among the groups (p < 0.05), showing an LPS dose-dependency.
Answer: LPS enhanced the signal transduction of 2GPI in liver cancer cells leading to activation of NF-B, which triggered downstream signal transduction and increased the expression of downstream factors. This suggests that LPS enhancement of 2GPI signal transduction may play a role in promoting the development of liver cancer.
Does lipopolysaccharide enhance Beta2-Glycoprotein I Activation of Nuclear Factor B in Liver Cancer Cells?