Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Problem:Question: Do mTHFR and ACE Polymorphisms Increase Susceptibility to Migraine Neither Alone Nor in Combination?
Answer: We could not replicate a previous study that showed significant increase in migraine susceptibility for two functional polymorphisms in genes affecting relevant pathways.
Solution:
no