Instructions: In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.
Input: Context: Aging of the skin is affected by intrinsic and extrinsic factors. Especially important extrinsic factor is ultraviolet radiation, which causes premature aging of the skin. Intrinsic aging is influenced by genetic factors, and changes in hormones. In menopause, changes in hormonal balance have been suggested to enhance aging of the skin.\Question: Do systemic estrogens have no conclusive beneficial effect on human skin connective tissue?
Output:
Accordingly, several studies have been accomplished, in which hormone replacement therapy (HRT) has been used in order to prevent skin aging at or after the menopause. In this overview the results of previous studies, and a study done recently, are critically reviewed.