Summarize the following:
When attempting to get two Sims to form a relationship, they cannot be related, nor can they be diametrically opposed to each other's traits. While it's technically possible to get two opposite Sims to date, doing so is difficult. Your Sims' genders don't factor into their dating choices. If you want your Sim to meet another Sim organically, you'll need to send them to a club, bar, park, or similarly social location. You can also just send your Sim out into the street if there are enough Sims around. Select the Sim with whom you want to pair your Sim to strike up a conversation. You will see literal green "+" signs appear above both your Sim's head and the other Sim's head while they talk; if you see a large majority of these, your Sims are compatible. You'll most likely see a few red "-" signs as well. As long as you see significantly more green positives than red negatives, you're set to proceed. If you see an influx of red negative signs, you'll have to find a different Sim with whom to pair your Sim. The easiest, lowest-risk way to do this is by conversing with the other Sim by selecting Friendly as a conversation option and then selecting dialogue options such as Ask About Day or Compliment Outfit. You want the "Friendship" meter to be at least 50 percent full; any lower than that, and your romantic attempts will fail. Avoid flirty (pink) dialogue options when building the friendship. Once your two Sims are friends (e.g., the "Friendship" bar is at 50 percent or higher), you can begin flirting with the other Sim by selecting the Romance conversation option and then selecting Flirt. If the other Sim is open to romance, you will see a pink bar appear below the green "Friendship" bar under both your Sim's name and the other Sim's name. If the pink bar doesn't appear, try building up the "Friendship" bar some more before attempting to flirt again. Building romance works in the same way as building friendship: select the Romance conversation option, then select light options such as Flirt or Compliment Appearance. Avoid physical actions until the "Romance" bar has grown a few times. Ideally, you'll wait to use physical options until the bar reaches the 30 percent mark. If the other Sim reacts unfavorably to something you do, select the Apologize conversation option before proceeding, then go back to light flirting or complimenting. Once the "Romance" bar is at least 30 percent full, select the Romance menu option, then select Ask to Be Boyfriend or Ask to Be Girlfriend in the resulting menu. This will usually result in the Sim becoming your Sim's partner. If the other Sim reacts poorly, go back to flirting until you've increase the "Romance" bar to around 50 percent, then try again. Once your Sim and their partner are dating, you can continue using Romance options such as holding hands, kissing, and so on to build the "Romance" bar. Once the "Romance" bar is 50 percent full or higher, you can ask the Sim to marry your Sim. If the bar is high enough, you'll even have an Elope option.

summary: Understand the limitations. Send your Sim to a social location. Have your Sim introduce themselves to another Sim. Look for positive signs. Build a friendship between the two Sims. Begin flirting. Wait to see if the other Sim accepts the flirting. Build the "Romance" bar to at least 30 percent. Ask the Sim to date. Continue building the relationship.

Summarize the following:
There are several types of medications that are used to help control IBD. Aminosalicylates target colon inflammation, but are less effective at treating the small intestine. These drugs are usually used to treat mild to moderate colitis. Sulfasalazine is effective, but side effects include nausea, vomiting, diarrhea, heartburn, and headache. Corticosteroids fight inflammation, but suppress all immune response instead of focusing on the colon. These drugs (prednisone, methylprednisolone) are used for moderate to severe colitis. Side effects include weight gain, excessive facial hair growth, mood swings, high blood pressure, type 2 diabetes, osteoporosis, bone fractures, cataracts, glaucoma, and an increased risk of infection. Azathioprine and mercaptopurine act slowly, so they're usually prescribed alongside a corticosteroid. Immunomodulators, like corticosteroids, suppress immune response to calm inflammation. They're usually used only when aminosalicylates and corticosteroids have failed. Cyclosporine is a very strong medication that begins to work within one or two weeks. Since it is so strong and comes with a range of severe side effects, it is generally only prescribed until less toxic medications can take effect. Infliximab and adalimumab fight intestinal inflammation specifically. Infliximab can cause problems in people with cancer or a history of heart disease. Antibiotics don't treat the colitis itself. If intestinal ulcers cause infection though, antibiotics will prevent further complications. Antibiotics can treat abscesses of fistulas (abnormal connections between organs or vessels) seen in Crohn's Disease and usually occurring in the small intestine. Tell your doctor if you develop a fever, which could indicate infection. Though it may sound "natural" or "herbal," biologic therapies take their name from the fact that they're developed from biological material usually protein. This treatment targets the chemicals responsible for inflammation. These fairly new medications are used for moderate to severe colitis if other treatments have failed. They're also known as anti-TNF agents. Tumor necrosis factor (TNF) is a naturally produced chemical responsible for inflammation. Biologic therapies produce antibodies that attach themselves to the TNF, so that it can be destroyed by the body. Your doctor must test you for tuberculosis before you can begin TNF. If your colitis is so severe that no medication, home cure, or alternative treatment can keep it in check, you might need to have a colectomy. During this surgery, part or all of your colon will be removed. Removal of your colon will lead to lifestyle changes. Although most people will be able to do most of the routine activities they did before, you have to live with a stoma (a hole in your abdomen from which waste is expelled). The only way to cure colitis completely is to have a total colectomy performed. Since a total colectomy can come with adverse side effects (like small bowel obstruction), though, a partial colectomy is sometimes done instead. The surgeon may also opt to perform a procedure that links the small intestine to the anus, thereby producing more normal bowel function.
summary: Consult your healthcare provider about medicinal treatments. Consider antibiotic use. Talk to your doctor about biologic therapies. Be prepared for surgery if necessary.