Instructions: In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.
Input: Context: Paraoxonase-1 (PON1) is an enzyme that prevents low-density lipoprotein (LDL) oxidation. The role of polymorphisms of PON1 determining early atherosclerotic changes is currently unclear.', 'Cross sectional cohort study.', 'Nine hundred and ninety-nine subjects from a population-based cohort were screened. Intima-media thickness (IMT) was measured by ultrasonography. Leu-Met55 and Gln-Arg192 polymorphism were determined.', 'No association between PON1 genotypes and IMT was found. This finding remained after adjusting for confounding factors.\Question: Are paraoxonase-1 gene Leu-Met55 and Gln-Arg192 polymorphisms associated with carotid artery atherosclerosis in a population-based cohort?
Output:
The PON1 Leu-Met55 and Gln-Arg192 polymorphisms are not major risk factors for atherosclerosis in the general Caucasian population.