TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Are immunologic marker paths for seroconversion : single determinations of immunoglobulin A and beta 2-microglobulin adequate to estimate time of HIV infection . Multicohort Analysis Project Workshop . Part II?
Answer: Further study of how serum IgA reflects HIV infection and careful clinical and statistical assessment of reduced beta 2M from 5 or 6 years after HIV infection are needed. The dependence of marker paths on mode of HIV transmission suggests that sexual transmission may have implications for HIV disease progression. The feasibility of using serum IgA and beta 2M, evaluable in single stored blood samples, to estimate time of HIV infection has been set back by our results.

SOLUTION: no

PROBLEM: Question: Is early reduction in number of T cells producing proinflammatory cytokines , observed after extracorporeal photopheresis , linked to apoptosis induction?
Answer: Since proinflammatory cytokines play a major role in the pathology of GvHD, their down-regulation post-ECP may produce a direct clinical benefit. The lowest number of IL2-, IFNgamma- and TNFalpha-expressing T cells occurred within the apoptotic population; however, Annexin V-negative T cells also demonstrated a marked reduction post-ECP. However, the lack of an increase in IL4 and IL10 expression indicates that this process was not a consequence of skewing toward a Th2 cytokine profile.

SOLUTION: no

PROBLEM: Question: Does resting-state functional network connectivity in prefrontal regions differ between unmedicated patients with bipolar and major depressive disorders?
Answer: As patients were unmedicated, the sample sizes were relatively small, although they were comparable to those in previous fMRI studies comparing BD and MDD.

SOLUTION:
yes