Detailed Instructions: Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Q: To explore the effects of methylglyoxal on endothelia cell migration.', 'Human umbilical vein endothelial cells (HUVECs) were stimulated by serial concentrations of methylglyoxal (MGO, 0, 25, 50, 100 and 200 mol/L) for 24 h, and the cell migration was assessed by scratch wound and Transwell assay. The expression of integrin 3 in the treated cells was examined by immunoblotting, and the effect of an anti-3 antibody, LM609, on cell migration was investigated.', 'Methylglyoxal significantly inhibited HUVEC migration in a concentration-dependent manner (P<0.05). Methylglyoxal decreased the expression of integrin 3 in a time- and concentration-dependent manner (P<0.05). LM609 also significantly inhibited HUVEC migration (P<0.05).
A:
Does [ Methylglyoxal inhibit human umbilical vein cell migration in vitro by down-regulating integrin3 ]?