The movie industry was born in Paris when Auguste and Louis Lumiere projected the first motion picture for a paying audience at the Grand Cafe on 28 December 1895. Many of Paris' concert/dance halls were transformed into movie theatres when the media became popular beginning in the 1930s. Later, most of the largest cinemas were divided into multiple, smaller rooms. Paris' largest cinema room today is in Le Grand Rex theatre with 2,700 seats.
Big multiplex movie theaters have been built since the 1990s. UGC Cine Cite Les Halles with 27 screens, MK2 Bibliotheque with 20 screens and UGC Cine Cite Bercy with 18 screens are among the largest.
In what decade did movie theaters become popular?
1930s

The city had a population of 1,307,402 according to the 2010 census, distributed over a land area of 372.1 square miles (963.7 km2). The urban area of San Diego extends beyond the administrative city limits and had a total population of 2,956,746, making it the third-largest urban area in the state, after that of the Los Angeles metropolitan area and San Francisco metropolitan area. They, along with the RiversideSan Bernardino, form those metropolitan areas in California larger than the San Diego metropolitan area, with a total population of 3,095,313 at the 2010 census.
What was the population of San Diego at the time of the 2010 census?
1,307,402

The BCG vaccine has limitations, and research to develop new TB vaccines is ongoing. A number of potential candidates are currently in phase I and II clinical trials. Two main approaches are being used to attempt to improve the efficacy of available vaccines. One approach involves adding a subunit vaccine to BCG, while the other strategy is attempting to create new and better live vaccines. MVA85A, an example of a subunit vaccine, currently in trials in South Africa, is based on a genetically modified vaccinia virus. Vaccines are hoped to play a significant role in treatment of both latent and active disease.
What does one option propose adding to the existing BCG vaccine?
subunit vaccine