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The first British settlement in what is now Tennessee was built in 1756 by settlers from the colony of South Carolina at Fort Loudoun, near present-day Vonore. Fort Loudoun became the westernmost British outpost to that date. The fort was designed by John William Gerard de Brahm and constructed by forces under British Captain Raymond Demere. After its completion, Captain Raymond Demere relinquished command on August 14, 1757 to his brother, Captain Paul Demere. Hostilities erupted between the British and the neighboring Overhill Cherokees, and a siege of Fort Loudoun ended with its surrender on August 7, 1760. The following morning, Captain Paul Demere and a number of his men were killed in an ambush nearby, and most of the rest of the garrison was taken prisoner.

Which Cherokee faction forced the surrender of Fort Loudoun in 1760?
Answer: Overhill Cherokees
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The thalidomide tragedy resurrected Kefauver's bill to enhance drug regulation that had stalled in Congress, and the Kefauver-Harris Amendment became law on 10 October 1962. Manufacturers henceforth had to prove to FDA that their drugs were effective as well as safe before they could go on the US market. The FDA received authority to regulate advertising of prescription drugs and to establish good manufacturing practices. The law required that all drugs introduced between 1938 and 1962 had to be effective. An FDA - National Academy of Sciences collaborative study showed that nearly 40 percent of these products were not effective. A similarly comprehensive study of over-the-counter products began ten years later.

When did the Kefauver-Harris Amendment became law?
Answer: 10 October 1962
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The expression of genes encoded in DNA begins by transcribing the gene into RNA, a second type of nucleic acid that is very similar to DNA, but whose monomers contain the sugar ribose rather than deoxyribose. RNA also contains the base uracil in place of thymine. RNA molecules are less stable than DNA and are typically single-stranded. Genes that encode proteins are composed of a series of three-nucleotide sequences called codons, which serve as the "words" in the genetic "language". The genetic code specifies the correspondence during protein translation between codons and amino acids. The genetic code is nearly the same for all known organisms.:4.1

How does the expression of genes encoded in DNA begin?
Answer:
by transcribing the gene into RNA