Historically, computers evolved from mechanical computers and eventually from vacuum tubes to transistors. However, conceptually computational systems as flexible as a personal computer can be built out of almost anything. For example, a computer can be made out of billiard balls (billiard ball computer); an often quoted example.[citation needed] More realistically, modern computers are made out of transistors made of photolithographed semiconductors.
Transistors are typically made up of what today?
photolithographed semiconductors

With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterialsfor example, the sulfonamides, the quinolones, and the oxazolidinonesare produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]
Besides semisytetic modifications, what advances in medicinal chemistry regarding antibacterials?
various natural compounds

Milena Sterio, American expert of international law, includes the former axis powers (Germany, Italy and Japan) and India among the great powers along with the permanent members of the UNSC. She considers Germany, Japan and Italy to be great powers due to their G7 membership and because of their influence in regional and international organizations. Various authors describe Italy as an equal major power, while others view Italy as an "intermittent great power" or as "the least of the great powers".
Which country is debated as intermittent and/or least of great powers?
Italy