Given a scientific passage and an answer, generate a question for the given answer.

Example input: Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Example output: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Example explanation: The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.
Q: Passage: The Prokaryotic Cell Recall that prokaryotes (Figure 22.10) are unicellular organisms that lack organelles or other internal membrane-bound structures. Therefore, they do not have a nucleus but instead generally have a single chromosomea piece of circular, double-stranded DNA located in an area of the cell called the nucleoid. Most prokaryotes have a cell wall outside the plasma membrane. Answer: nucleoid
A:
Prokaryotic cells do not have a nucleus but instead generally have a single chromosome, a piece of double-stranded dna located in an area of the cell called the what?