Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.

Output: Which enzyme is inhibited by a drug fostamatinib?

Input: Consider Input: Associacao Cultural e Desportiva Potyguar Seridoense play their home games at Estadio Municipal Coronel Jose Bezerra.

Output: What is the home venue of Associacao Cultural e Desportiva Potyguar Seridoense?

Input: Consider Input: Cynthia Nelson (Mariette Hartley), a teacher at the local orphanage, talks with a pastor while watching the sun set before getting ready for a fundraising costume party. Cynthia mentions the "Santa Ana winds" which the pastor states are an evil omen. One the orphans, Tommy, wanders into the nearby cemetery where he faintly hears a voice ordering "To rise; it is time." Vampire women rise from their graves and chase Tommy into the clutches of Count Yorga, who was waiting for them. Yorga, having been in the area while creating his undead harem and hiding them in the cemetery, has purchased a manor next to the orphanage. His intent is to prey on the children and staff there to satisfy his and his vampire-brides' thirst for blood and presumably create an undead-army from the community's women. In his human guise, he goes to the orphanage during their costume party and fund raiser, biting on of the guests, Mitzi, outside the event room before introducing himself to those present to which he meets and becomes smitten with Cynthia. Upon returning to his manor and a throne room of sorts where he's greeted by his Brudah and his female vampire servants, sends his undead brides to her house, using mind-control to get Cynthia's family into one room before having the brides break in and attack them. Cynthia's father and mother are killed after being drained of their blood, while Cynthia's sister, Ellen, is fed upon and transformed into a new vampire bride to serve Yorga. Tommy, who was sleeping over, is untouched having fallen under Yorga's power, and blankly looks on as the carnage unfolds. Cynthia is subdued (though not bitten) and carried by the brides to Yorga's residence where she awakens with no memory of the attack. Yorga tells Cynthia that her family were in a car accident and she was left in his care during their recovery. Yorga tries to charm the young woman into willingly becoming his bride though he is warned by his live-in witch that Cynthia will bring his end if he doesn't kill her or turn her into a vampire soon. The next morning, Jennifer, the Nelsons' mute maid, finds the massacre scene and calls the police. By the time the police arrive though, all of the evidence has been mysteriously cleared away, and Tommy claims that nothing has happened. Later that same morning, Bruddah, Yorga's hulking, facially disfigured servant (like Yorga, also returning from an on-screen death in the first film) drags the corpses of Cynthia's mother and father to a quicksand pit on Yorga's property, disposing of the physical evidence while likewise bring Ellen's body to Yorga to complete her transformation. Despite the confusion, David Baldwin, Cynthia's fiance, is suspicious about the Nelsons' disappearance. Meanwhile, memories of the attack on her family slowly start to resurface in Cynthia's mind as she stays within Yorga's manor. Jennifer, suspicious about Tommy's involvement with the Nelson's disappearance and his visits to Yorga's mansion, loses her patience and slaps Tommy who stares at her in a vengeful manner. Meanwhile, Yorga goes to claim Mitzi, killing her boyfriend near their boat house then biting her, draining her blood and making her a new bride. Hours later, Ellen's fiance Jason is lured to Yorga's mansion by Tommy, on the promise that he would find Ellen. Once at the mansion, Tommy disappears, while Jason is reunited with Ellen. However, in her vampirized state, she is now evil and laughs at him for "not loving her anymore", distracting him before her fellow brides attack him from behind. Jason breaks free, only to run into Count Yorga, who chases Jason down a hall and strangles him. Bruddah tosses Jason's body into the throne/coffin room for the brides, including Ellen and newly vampiric Mitzi, to feed upon. That evening, Reverend Thomas phones Jennifer, but it is revealed she lay dead on her bed with a large knife sticking out of her chest. From her window, Tommy can be seen walking
Output: Who gives Yorga the final push that sends him plummeting to the ground?