[Q]: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. Two university students studied different types of drugs for their exams. Kate studied statins, while Carol studied anti-depressants. Which student learned less about inducing the expression of low density lipoprotein (LDL) receptors in the liver?
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[A]: Carol

input: Please answer the following: Clouds on Earth are made of water vapor. Venus's clouds are a lot less pleasant. They are made of carbon dioxide, sulfur dioxide and large amounts of corrosive sulfuric acid! The atmosphere of Venus is so thick that the pressure on the surface of Venus is very high. In fact, it is 90 times greater than the pressure at Earth's surface! The thick atmosphere causes a strong greenhouse effect. As a result, Venus is the hottest planet. Even though it is farther from the Sun, Venus is much hotter even than Mercury. Temperatures at the surface reach 465C (860F). That's hot enough to melt lead! In year 2200, David is an astronaut and an avid galaxy hopper from a planet hundred light years away. He ended up in the solar system in search of water. He identified three planets, planet A, planet B and planet C. Little did he know that less than a hundred years ago people used to call planet A as Earth, planet B as Venus, and planet C as Mercury. Would planet B have stronger or weaker greenhouse effect than planet A?
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output: stronger

Please answer this: Clouds on Earth are made of water vapor. Venus's clouds are a lot less pleasant. They are made of carbon dioxide, sulfur dioxide and large amounts of corrosive sulfuric acid! The atmosphere of Venus is so thick that the pressure on the surface of Venus is very high. In fact, it is 90 times greater than the pressure at Earth's surface! The thick atmosphere causes a strong greenhouse effect. As a result, Venus is the hottest planet. Even though it is farther from the Sun, Venus is much hotter even than Mercury. Temperatures at the surface reach 465C (860F). That's hot enough to melt lead! John liked studying about the planets in our solar system. He recently studied and made comparisons between Earth's and Venus's atmosphere. He was amazed with what he found out. Which planet has more clouds made of carbon dioxide?
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Answer: Venus

Problem: Once again, a mutation is the change in the DNA or RNA sequence. In multicellular organisms, mutations can be subdivided into germline mutations and somatic mutations. Germline mutations occur in the DNA of sex cells, or gametes, and are therefore potentially very serious. These mutations can be passed to the next generation. If the zygote contains the mutation, every cell in the resulting organism will have that mutation. If the mutation results in a disease phenotype, the mutation causes what is called a hereditary disease. Somatic mutations , which occur in somatic, or body, cells, cannot be passed to the next generation (offspring). Mutations present in a somatic cell of an organism will be present (by DNA replication and mitosis) in all descendants of that cell. If the mutation is present in a gene that is not used in that cell type, the mutation may have no effect. On the other hand, the mutation may lead to a serious medical condition such as cancer. Dan studied multicellular organisms that presented mutations. Group A presented gemline mutations, while group B presented somatic mutations. He was fascinated by these organisms. Which group had more organisms having potentially serious mutations?

A: Group A

Problem: Given the question: A plant's first line of defense against abiotic stress is in its roots. If the soil holding the plant is healthy and biologically diverse, the plant will have a higher chance of surviving stressful conditions.The plant responses to stress are dependent on the tissue or organ affected by the stress. For example, transcriptional responses to stress are tissue or cell specific in roots and are quite different depending on the stress involved.One of the primary responses to abiotic stress such as high salinity is the disruption of the Na+/K+ ratio in the cytoplasm of the plant cell. High concentrations of Na+, for example, can decrease the capacity for the plant to take up water and also alter enzyme and transporter functions. Evolved adaptations to efficiently restore cellular ion homeostasis has led to a wide variety of stress tolerant plants.Facilitation, or the positive interactions between different species of plants, is an intricate web of association in a natural environment. It is how plants work together. In areas of high stress, the level of facilitation is especially high as well. This could possibly be because the plants need a stronger network to survive in a harsher environment, so their interactions between species, such as cross-pollination or mutualistic actions, become more common to cope with the severity of their habitat.Plants also adapt very differently from one another, even from a plant living in the same area. When a group of different plant species was prompted by a variety of different stress signals, such as drought or cold, each plant responded uniquely. Hardly any of the responses were similar, even though the plants had become accustomed to exactly the same home environment.Rice (Oryza sativa) is a classic example. Rice is a staple food throughout the world, especially in China and India. Rice plants experience different types of abiotic stresses, like drought and high salinity. These stress conditions have a negative impact on rice production. Genetic diversity has been studied... Two farmers provide a neighboring city with plenty of produce every year. Brick farm has a lot of plant problems, their plants experience abiotic stress. Boulder farm had a good production because their plants presented almost no signs of abiotic stress. Which farm has a healthier soil?
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The answer is:
Boulder

Problem: Old age begins in the mid-60s and lasts until the end of life. Most people over 65 have retired from work, freeing up their time for hobbies, grandchildren, and other interests. Stamina, strength, reflex time, and the senses all decline during old age, and the number of brain cells decreases as well. The immune system becomes less efficient, increasing the risk of serious illnesses such as cancer and pneumonia. Diseases such as Alzheimer's disease that cause loss of mental function also become more common. Two neighboring towns had different demographics. Hill town had younger inhabitants, most of them in their 30's and 40's. Lake town was inhabited by elderly people, most of them above 65 years of age. Which town had fewer people that have retired from work?

A:
Hill