Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: To study the mechanism of centrosome duplication in cycling cells, we established a novel system of multiple centrosome formation in two types of cells: CHO cells treated with RO3306, a Cyclin-dependent kinase 1 (Cdk1) inhibitor and DT40 cells, in which Cdks were knocked out by chemical genetics. Cdk1-inactivated cells initiated DNA replication and centrosome duplication at the onset of S phase. They became arrested at the end of G2, but the centrosome cycle continued to produce supernumerary centrioles/centrosomes without DNA endoreplication in those cells. Centrosomes were amplified in a highly synchronous and reproducible manner: all of them were located next to the nucleus and spread widely apart from each other with several m in distance. Double knockout of Cdk1 and Cdk2 caused cell cycle arrest at G1/S and centrosomes were no longer duplicated. However, cells continued to grow and increased their volume over 10-fold during 48 hr of culture. Centrosome components, including -tubulin and Cep135, were synthesized and accumulated during the arrest, allowing rapid centrosome multiplication upon recovery from the cell cycle arrest or expression of exogenous Plk4 in G1/S cells. Thus centrosome amplification results from the discoordination of the centrosome cycle from the progression of other cell cycle events, which is controlled by different levels of Cdk activities.
[EX A]: Where in the cell do we find the protein Cep135?

[EX Q]: Brigadier Sir Iltyd Nicholl Clayton CBE (1886 -- 30 June 1955) was a British Army officer notable for his attachment to the Middle East Office in Cairo during and after World War II and his involvement in the formation of Arab League and formulation of post-war British policy in the Middle East.
[EX A]: Who did Iltyd Nicholl Clayton serve for?

[EX Q]: The army defending Constantinople was relatively small, totaling about 7,000 men, 2,000 of whom were foreigners. At the onset of the siege, probably fewer than 50,000 people were living within the walls, including the refugees from the surrounding area.:32 Turkish commander Dorgano, who was in Constantinople in the pay of the Emperor, was also guarding one of the quarters of the city on the seaward side with the Turks in his pay. These Turks kept loyal to the Emperor and perished in the ensuing battle. The defending army's Genoese corps were well trained and equipped, while the rest of the army consisted of small numbers of well-trained soldiers, armed civilians, sailors and volunteer forces from foreign communities, and finally monks. The garrison used a few small-calibre artillery pieces, which nonetheless proved ineffective. The rest of the city repaired walls, stood guard on observation posts, collected and distributed food provisions, and collected gold and silver objects from churches to melt down into coins to pay the foreign soldiers. The Ottomans had a much larger force. Recent studies and Ottoman archival data state that there were about 50,000-80,000 Ottoman soldiers including between 5,000 and 10,000 Janissaries, *70 cannons:139-140 an elite infantry corps, and thousands of Christian troops, notably 1,500 Serbian cavalry that the Serbian lord ura Brankovic was forced to supply as part of his obligation to the Ottoman sultanjust a few months before, he had supplied the money for the reconstruction of the walls of Constantinople. Contemporaneous Western witnesses of the siege, who tend to exaggerate the military power of the Sultan, provide disparate and higher numbers ranging from 160,000 to 200,000 and to 300,000.
[EX A]:
Which force was smaller, the Turkish or the Ottomans?