The Broncos' rush defense, which allowed a combined 95 yards in their first four games, surrendered 148 yards in a stunning home loss to the New York Giants, while the offense rushed for only 46 yards, after averaging 143 yards in the previous four games. Quarterback Trevor Siemian threw two interceptions, one of which was returned for a touchdown by Giants' cornerback Janoris Jenkins, while placekicker Brandon McManus missed a 33-yard field goal and had another attempt blocked. The Broncos' offensive woes in the red zone continued, scoring only one touchdown out of four opportunities. Backup quarterback Brock Osweiler saw brief action late in the first half, after Siemian sprained his shoulder on a diving attempt, as he unsuccessfully tried to prevent Jenkins from reaching the end zone after an interception. This was the first of two games in which Broncos wore their alternate all-navy blue jerseys; the other was Week 14 vs. the New York Jets.

How many more rushing yards did the Broncos' defense give up compared to the amount they rushed for?
A: 102

The 49ers' 8th match was an Interconference duel with the Broncos at Wembley Stadium. In the first quarter the 49ers took the lead as kicker Joe Nedney got a 34-yard field goal. They soon trailed in the third quarter when QB Tim Tebow scrambled 1 yard for a touchdown; followed in the fourth quarter by kicker Matt Prater hitting a 32-yard field goal. They soon went on a scoring rally to take the lead with QB Troy Smith scrambling a yard for a touchdown, followed by his 28-yard TD pass to WR Michael Crabtree. Then RB Frank Gore got a 3-yard TD run to put the 49ers up 24-10. The lead was narrowed when QB Kyle Orton made a 1-yard TD pass to WR Brandon Lloyd (with a failed PAT). With the win, the 49ers went into their bye week at 2-6.

How many more losses than wins did the 49ers have after the game?
A: 4

Hoping to rebound from their home loss to the Jaguars, the Broncos flew to the RCA Dome for an intraconference fight with the defending-Super Bowl champions, the Indianapolis Colts. In the first quarter, Denver galloped to an early lead with kicker Jason Elam getting a 35-yard field goal, along with QB Jay Cutler (Indiana native) complete a 7-yard TD pass to WR Brandon Marshall. In the second quarter, the Colts responded with RB Joseph Addai got a 14-yard TD run. The Broncos replied with Elam kicking a 22-yard field goal, yet Indianapolis took the lead with QB Peyton Manning completing a 9-yard TD pass to TE Dallas Clark. In the third quarter, Denver began to struggle as Manning got a 1-yard TD run, along with completing a 3-yard TD pass to Clark. The Broncos got close with Cutler getting a 2-yard TD run. However, in the fourth quarter, the Colts sealed their win with Manning completing a 5-yard TD pass to WR Reggie Wayne, along with kicker Adam Vinatieri nailing a 22-yard field goal.

How many touchdown receptions did Dallas Clark catch?
A:
2