Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Input: Consider Input: Context: To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis. Three multicenter, randomized, double-masked, placebo-controlled, dose-ranging phase III studies: SHIELD, INSURE, and ENDURE. A total of 118 patients with Behcet's uveitis (SHIELD study); 31 patients with active, noninfectious, non-Behcet's uveitis (INSURE study); and 125 patients with quiescent, noninfectious, non-Behcet's uveitis (ENDURE study) were enrolled. After an initial subcutaneous (s.c.) loading phase in each treatment arm, patients received s.c. maintenance therapy with secukinumab 300 mg every 2 weeks (q2w), secukinumab 300 mg monthly (q4w), or placebo in the SHIELD study; secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the INSURE study; or secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the ENDURE study. Reduction of uveitis recurrence or vitreous haze score during withdrawal of concomitant immunosuppressive medication (ISM). Other end points included best-corrected visual acuity, ISM use (expressed as a standardized ISM score), and safety outcomes. After completion or early termination of each trial, there were no statistically significant differences in uveitis recurrence between the secukinumab treatment groups and placebo groups in any study. Secukinumab was associated with a significant reduction in mean total post-baseline ISM score (P = 0.019; 300 mg q4w vs. placebo) in the SHIELD study. Likewise, secukinumab was associated with a greater median reduction in ISM score versus placebo in the INSURE study, although no statistical analysis of the difference was conducted because of the small sample size. Overall, there was no loss in visual acuity reported in any treatment group during follow-up in all 3 studies. According to descriptive safety statistics, the frequencies of ocular and nonocular adverse events seemed to be slightly higher among secukinumab groups versus placebo across the 3 studies. The primary efficacy end points of the 3 studies were not met. The secondary efficacy data from these studies suggest a beneficial effect of secukinumab in reducing the use of concomitant ISM.
Question: Which molecule is targeted by a monoclonal antibody Secukinumab?

Output: interleukin-17a

Input: Consider Input: Context: John Strangways, the British Intelligence (SIS) Station Chief in Jamaica, is ambushed, killed, and his body taken by three assassins known as the "Three Blind Mice". In response, MI6 agent James Bond (007) is summoned to the office of his superior, M. Bond is briefed to investigate Strangways' disappearance and to determine whether it is related to his cooperation with the American Central Intelligence Agency (CIA) on a case involving the disruption of Cape Canaveral rocket launches by radio jamming.Upon his arrival at Kingston Airport, a female photographer tries to take Bond's picture and he is shadowed from the airport. He is picked up by a chauffeur, who Bond determines to be an enemy agent. Bond instructs him to leave the main road and, after a brief fight, Bond starts to interrogate the driver, who then kills himself with a cyanide-embedded cigarette.During his investigation Bond sees a picture of a boatman named Quarrel with Strangways. Bond locates Quarrel but finds him to be un-cooperative when he interviews him. Bond also recognises Quarrel to have been the driver of the car that chased him from the airport. Bond follows Quarrel and is about to be beaten by him and a friend when the fight is interrupted by the man from the airport who has been following Bond: he reveals himself to be CIA agent Felix Leiter and that not only are the two agents on the same mission, but also that Quarrel is helping Leiter. The CIA has traced the mysterious radio jamming of American rockets to the Jamaica vicinity, but aerial photography cannot see the exact location of its origin. Quarrel reveals that he has been guiding Strangways around the nearby islands to collect mineral samples. He also tells about the island of Crab Key, owned by the reclusive Dr. No, who operates a bauxite mine which is rigorously protected against trespassers by an armed security force and low-scan radar.After finding a receipt in Strangways' house about mysterious rocks naming, Professor R.J. Dent, Bond meets with Dent who says he had assayed the samples for Strangways and determined them to be ordinary rocks. This visit makes Dent wary and he takes a boat to Crab Key where Dr. No expresses displeasure at Dent's failure to kill Bond and orders him to try again, this time with a large venomous spider. Bond survives and kills the spider.Bond becomes friendly with Strangways' secretary, Miss Taro and agrees to meet her at her home in the hills above Kingston. While driving there, Bond is attacked by several men driving a large hearse. He is able to outmaneuver them and the hearse is run off the mountain road and explodes. When Bond shows up at Taro's house, she's surprised to see him, a fact that Bond notes easily. She goes into her bedroom and talks on the phone to her boss, who tells her to keep Bond occupied for a few hours. Bond and Taro spend that time in bed.Bond makes a phone call, ostensibly asking for a taxi but actually talking to the local police, who show up soon after and arrest Taro. Bond then sets a trap for Dent and waits for him to show. Dent steals into the bedroom and fires several silenced shots into the bed, which Bond rigged to look like it was occupied. Bond forces Dent to drop his pistol and begins to interrogate him about Strangways and his radioactive rock samples, which Dent tried to cover up. Dent is able to recover his pistol, finding it empty and Bond coldly shoots him dead.Having detected radioactive traces in Quarrel's boat, where Strangways' mineral samples had been, Bond convinces a reluctant Quarrel to take him to Crab Key. On the beach there, Bond meets the beautiful Honey Ryder, dressed only in a white bikini, who is collecting shells. At first she is suspicious of Bond but soon decides to help him, leading them all inland to an open swamp. After nightfall they are attacked by the legendary "dragon" of Crab Key which turns out to be a flame-throwing armoured vehicle. In the resulting gun battle, Quarrel is incinerated by the flame-thrower whilst Bond and Honey are
Question: Where did Dent took the boat to?

Output: crab key

Input: Consider Input: Context: Opening narrationAn explanation that our knowledge of Venus is very incomplete and only by imagination can we glimpse the planet, but the producers of the film believe the heroic Soviet people will see the planet with their own eyes.Opening sceneThree soviet spaceships CCCP Sirius Vega and Capella approach Venus after completing a 200 million kilometer journey. Suddenly before anyone can react Capella is destroyed with all hands by a stray meteor. The crew of the Sirius are devastated by the news, and reflect on how close they came only to die within sight of their destination. A message received from Earth advises that a replacement for Capella is launching soon and will reach Venus in 4 monthsAlexi ( ) one of the crew from Sirius doesnt want to wait and suggests they modify the robot glider on Vega, so. Venus needs to be seen by human eyes. He explains if anything happens he will not call for help. His life is his, to do with as he desires.Mr Kern (Georgi Tejkh) On board Vega must have the final say on the launch. Rather than use the glider he recommends landing the two ships rather than wait for the spare ship from Earth, but first he has to check the figures for the safety margins. To do this he activates the ships robot JohnThe robot proposes a different plane. Three crew members go down in the glider, three more go down in the Sirius, leaving Vega in orbit manned by Masha (Kyunna Ignatova) Masha feels cheated by the plan but realizes it is the only way the mission can succeed As they plan to land a strange red light is seen through the cloud cover. They decide to try and land close to that position. It is decided the glider will go down first, and try and identify a good landing place. Sirius will followThe glider finds a location but as it drops the beacon to mark the spot for Sirius it is blown off course and heads for a dangerous landing in a swampy region. From orbit Sirius cant re-establish contact. Unsure what may have happened Sirius decides to land at the beacon and try and find the crew of the gliderThe Sirius lands successfully and begins testing the environment to see if they can go outside. Using an external microphone they listen to the sounds of Venus. At one point they hear what sounds like a womans voice singing. Understanding that little can be accomplished from the ship they decide to outside and explore. As Alexi explores away from the ship he is attacked by some strange tentacle creature. The other crew dont realize the danger and continue to check instruments for signs of the glider. They discover two distinct signals. One they suspect is the glider, and one that is moving should be JohnFinally the others realize Alexis situation and rescuing him from the plant like creature. The creature responds by first releasing Alexi then encloses itself in a protective shellIn the meantime Masha has confirmed the other crew is alive and has pin-pointed their location, approximately 32 kilometers away. The fact John is active proves crew members must have survived because hed been disassembled for the flight downAt the other landing site Kern, working with the partially completed robot search for parts of the robot to complete the job of assembly. One of the other crew is firing ant strange reptilian creatures that keep attacking Meanwhile the crew of Sirius have gotten their rover working and set off to help the crew of Vega. On the way they see a brontosaurs and stop to take a blood sample from the slow moving creature. While doing this, Masha confirms that the Vegas crew is moving towards the Sirius location.The crew from the Vega begin to feel ill and fevered, they are concerned that the rips in their suit may have allowed them to get sick from Venusians germs. The crews of the Sirius reach the shore of a large body of water and decide to cross it rather than go around. As they prepare to submerge they hear the same strange womans voice. Pausing to investigate, they find nothing and press onBack with the Vega crew they have been caught in a rain storm and John cautions that he may soon malfunction because of the water. Schebra (Yuri Sarantsev) Is
Question: Allan and Ivan leave who in orbit?
Output: masha