input: Please answer the following: Information: - Immunoglobulin M, or IgM for short, is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to an antigen. The spleen, where plasmablasts responsible for antibody production reside, is the major site of specific IgM production. - Hyper IgM syndromes is a group of primary immune deficiency disorders characterized by defective CD40 signaling; "via" B cells affecting class switch recombination(CSR) and somatic hypermutation. Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum Immunoglobulin M (IgM) levels and a considerable deficiency in Immunoglobulins G (IgG), A (IgA) and E (IgE). As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections. - Macrophages (from Greek "" ("makros") = large, "" ("phagein") = to eat) are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the types of proteins specific to healthy body cells on its surface in a process called phagocytosis. These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense (innate immunity) and also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes. For example, they are important as antigen presenters to T cells. In humans, dysfunctional macrophages cause severe diseases such as chronic granulomatous disease that result in frequent infections. - B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system by secreting antibodies. Additionally, B cells present antigen (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines. - Hyper - IgM syndrome type 3 is a form of Hyper IgM syndrome characterized by mutations of the CD40 gene . In this type , Immature B cells can not receive signal 2 from helper T cells which is necessary to mature into mature B cells . - IGE (Internet Gaming Entertainment) is a company which trades in virtual currency and accounts for MMORPGs. One of the main dealers in virtual economy services, members of the gaming community were often critical of IGE, as its services may allow players to break rules in online games. - In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the "CD4" gene. What entity does 'hyper-igm syndrome type 3' has the relation 'instance of' with?
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output: disease

input: Please answer the following: Information: - Russell Philip Taylor MBE ( born 8 July 1960 ) is a British writer , journalist and composer . He is best known as half of the team ( with Charles Peattie ) that created the comic strip Alex . He studied at Abingdon School and read Russian and Philosophy at St Anne 's College , Oxford . He was appointed MBE in 2002 . He also writes TV and film music with Steve Cooke . Among others , they composed the music for the documentaries The Dying Rooms in 1995 and Chosen and Saving Africa 's Witch Children -- both of which won BAFTAs in April 2009 . He has also written books on Russia and marathon running . Taylor is a supporter of Tottenham Hotspur football club , and as a private joke ( and to avoid libel accusations ) always names characters who are fired in the Alex strip after Tottenham footballers . - A cartoonist (also comic strip creator) is a visual artist who specializes in drawing cartoons. This work is often created for entertainment, political commentary, or advertising. Cartoonists may work in many formats, such as animation, booklets, comic strips, comic books, editorial cartoons, graphic novels, manuals, gag cartoons, graphic design, illustrations, storyboards, posters, shirts, books, advertisements, greeting cards, magazines, newspapers, and video game packaging. - St Anne's College is one of the constituent colleges of the University of Oxford in England. Formerly a women's college, it has been coeducational since 1979. Founded in 1879 as The Society of Oxford Home-Students, it received its college status in 1952, and today it is one of the larger colleges in Oxford, with around 450 undergraduate and 200 graduate students in a roughly equal mix of men and women. The college is known for its progressive outlook, its academic strength in both the humanities and the sciences, its mix of architecture, and its library the largest college library in Oxford. - Charles Peattie (born 3 April 1958) is a British cartoonist, best known as half of the team (with Russell Taylor) that creates the comic strip Alex. He has two daughters and two sons. He lives in London. - The University of Oxford (informally Oxford University or simply Oxford) is a collegiate research university located in Oxford, England, United Kingdom. While having no known date of foundation, there is evidence of teaching as far back as 1096, making it the oldest university in the English-speaking world and the world's second-oldest university in continuous operation. It grew rapidly from 1167 when Henry II banned English students from attending the University of Paris. After disputes between students and Oxford townsfolk in 1209, some academics fled northeast to Cambridge where they established what became the University of Cambridge. The two "ancient universities" are frequently jointly referred to as "Oxbridge". What entity does 'russell taylor ' has the relation 'occupation' with?
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output:
cartoonist