Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Input: Question: Is circadian variation in serum cortisol during hydrocortisone replacement attributable to changes in cortisol-binding globulin concentrations?
Answer: Circadian variation in serum cortisol during hydrocortisone replacement is not attributable to changes in cortisol-binding globulin concentration. Changes in serum cortisol levels may thus be explained by other factors including 11 -hydroxysteroid dehydrogenase type 1 activity or circadian changes in the binding properties of CBG.
Output:
no