In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: In disorders related to substance use, what is physical dependence?
Options: <1> In a physical process of short duration. <2> In an intense sense of dissatisfaction for not being able to consume the substances. <3> In the action of consuming drugs producing a state of intoxication with psychoactive effect. <4> In a series of physical and psychic changes that take place after the administration of a substance. <5> In a state of physical adaptation manifested by intense physical disturbances when the administration of the drug is interrupted.
5

Question: With vaginal ultrasound, from how long after conception is it possible to see an embryo with a heartbeat?
Options: <1> Between 14 and 21 days. <2> Between 21 and 28 days. <3> Between 28 and 35 days. <4> Between 35 and 42 days. <5> Between 42 to 49 days.
2

Question: A pediatrician wants to study overweight in children of 14 years, according to the values of the BMI (body mass index). To estimate the necessary sample size, it proposes a confidence level of 95% and a precision of 1 unit of BMI. What other parameters do you need to know to determine the sample size?
Options: <1> The average BMI in the population. <2> The variance of the BMI. <3> The mean and standard deviation of the BMI. <4> The size of the population and the average BMI. <5> The standard deviation of the BMI and the population size.
2