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Attack. Note your opponent's weakness. Check the defending Pokemon's resistance. Inflict damage. Discard knocked out Pokemon.
You have to have the right amount and type of Energy needed for the attack cost (listed on the card to the left of the attack name) attached to that Pokemon in order to attack. Some attacks require colorless energy. There are indicated by white stars, and can be any type of energy. Other attacks will require specific energy types. Most cards have a Weakness to a particular type. It will receive additional damage if your Pokemon is of the type it has weakness to. It will receive less damage if your Pokemon is of the type it has resistance to. The damage an attack inflicts will be to the right of the attack name. There are also some effects that are listed beneath some attacks that can increase the damage output, so watch out for those! This damage is placed on the defending Pokemon (your opponent's Active Pokemon). In game, damage will be referred to as damage counters, with each one representing 10 damage. You can keep track of these damage counters by using official counters, any sort of small flat objects, or with dice. Pokemon with 0 HP (the amount of damage is greater than or equal to the HP of the Pokemon) are knocked out. Place them in their owner's discard pile, along with any Energies or items that may be attached, and any or all evolutions. Then, you can take a Prize card.