Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Ex Input:
Abstract: The pharmacokinetics of oral and intravenous bromide was studied in 7 adult volunteers, who served as their own controls. They received 1 ml/kg of 3% sodium bromide, equivalent to 30 mg/kg bromide. Oral bioavailability ranged between 75-118% with a mean of 96 +/- 6%. Elimination T1/2 was 11.9 +/- 1.4 days after oral administration and 9.4 +/- 1.5 days after I.V. administration (P greater than 0.10). The employment of this ion for calculation of extracellular fluid and assessment of its potential significance in environmental toxicology necessitates accurate data on its disposition characteristics.
Which is the apt title for the abstract? option1: Pharmacokinetics of oral and intravenous bromide in normal volunteers. option2: Toluidine blue in the detection of perineal lacerations in pediatric and adolescent sexual abuse victims.

Ex Output:
Pharmacokinetics of oral and intravenous bromide in normal volunteers.

Ex Input:
Abstract: Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) to patients with chronically impaired renal function has been reported to cause abrupt and sustained reductions in renal plasma flow (RPF), glomerular filtration rate (GFR), and solute and water excretion in association with decreased renal prostanoid production. However, the time course of these acute effects and whether they are sustained during chronic exposure to the NSAIDs are unknown. Accordingly, using standard clearance and balance techniques, we investigated the effects of acute (zero to four hours) and chronic (five days) oral administration of two different NSAIDs on renal function in patients with stable, mild to moderate chronic renal insufficiency (CRI) and in normal subjects. In patients, acute oral administration of ketoprofen (K) and indomethacin (I) resulted in significant decreases in GFR (K: from 36 +/- 3 to 20 +/- 4 ml/min, P = 0.001; I: from 37 +/- 6 to 30 +/- 7 ml/min, P = 0.032; in RPF (K: from 194 +/- 21 to 146 +/- 21 ml/min, P = 0.002; I: from 222 +/- 33 to 147 +/- 18 ml/min, P = 0.016); and in urinary PGE2 excretion (K: from 0.60 +/- 0.25 to 0.08 +/- 0.02 ng/min, P = 0.05; I: from 0.34 +/- 0.06 to 0.18 +/- 0.06 ng/min, P = 0.042). Fractional excretion of sodium chloride and fractional free water clearance (CH2O/CIn) also decreased significantly after both agents. In normal subjects, GFR and RPF were not significantly decreased after acute dosing, whereas urinary PGE2 and fractional excretions of NaCl and free water decreased significantly.(ABSTRACT TRUNCATED AT 250 WORDS)
Which is the apt title for the abstract? option1: Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency. option2: Functional anatomy of the shoulder complex.

Ex Output:
Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency.

Ex Input:
Abstract: Supramaximal medial and lateral rectus surgery was performed to correct horizontal deviations in seven cases of sixth nerve palsy and three cases of third nerve palsy, with satisfactory results in most cases. The advantages and disadvantages of such procedures are discussed.
Which is the apt title for the abstract? option1: Supramaximal horizontal rectus surgery in the management of third and sixth nerve palsy. option2: Lack of acute effects of ascorbic acid on spirometry and airway responsiveness to histamine in subjects with asthma.

Ex Output:
Supramaximal horizontal rectus surgery in the management of third and sixth nerve palsy.