Given an abstract of a paper, generate a title for this paper such that conveys the key focus of the paper.

Ex Input:
Abstract: The effect of tauroursodeoxycholate (TU) infusion on the plasma level and biliary transport maximum (Tm) of sulfobromophthalein (BSP) was examined in male rats during a continuous intravenous infusion of BSP with different TU infusion rates. The infusion rate of 0.6 mumol/min/100 gm body weight of TU caused significantly higher bile flow and BSP Tm values compared with the respective control values in rats with only a BSP infusion. These values, however, were significantly lower than values obtained by an equimolar infusion of taurocholate (TC). The higher infusion rates of TU (1.2 and 1.8 mumol/min/100 gm) tended to cause higher bile flow rates, but the BSP Tm value did not increase beyond the value obtained at the lower infusion rate (0.6 mumol/min/100 gm). In the highest TU infusion rate study (1.8 mumol/min/100 gm), plasma BSP concentrations were significantly higher than corresponding control values or values at a lower TU or TC infusion rate. It was concluded that in rats TU can significantly increase the BSP Tm, but to a lesser extent than TC. Furthermore, it was suggested that TU infusion at a higher rate significantly interferes with the hepatic uptake (or storage) of BSP.

Ex Output:
Effect of tauroursodeoxycholate on the biliary transport maximum of sulfobromophthalein in the rat.

Ex Input:
Abstract: Twenty-two patients with evidence of systemic vasculitis and peripheral neuropathy were clinically and electrophysiologically investigated in a retrospective study. Ten had a polyarteritis nodosa, 6 a probable polyarteritis nodosa, and 6 a Churg-Strauss syndrome. Nine patients presented clinically with mononeuropathy or mononeuropathy multiplex considered typical of ischemic involvement of peripheral nerve; nine had more diffuse neuropathy, two of them a symmetric polyneuropathy. EMG examination revealed more diffuse neuropathy than clinically predicted. Findings were of acute or subacute axonal neuropathy.

Ex Output:
Peripheral neuropathy in systemic vasculitis: clinical and electrophysiologic study of 22 patients.

Ex Input:
Abstract: The dose-response curves of the central and peripheral airways to intravenously injected nicotine were studied in 55 anesthetized dogs. With intact vagi, nicotine caused a dose-dependent increase in central airway resistance (Rc) similar to the increase in peripheral airway resistance (Rp) at concentrations ranging from 4 to 64 micrograms/kg. However, the responses of both Rc and Rp fell progressively when sequential doses of nicotine greater than 256 micrograms/kg were administered. With intact vagi and the administration of propranolol, there was a greater increase in Rp than in Rc at a nicotine dose of 64 micrograms/kg (P less than 0.05). With vagotomy, the responsiveness of both central and peripheral airways to nicotine decreased with doses of nicotine less than 64 micrograms/kg, but with doses of nicotine greater than 256 micrograms/kg the suppressive effect of nicotine on both Rc and Rp was less than that seen with intact vagi. Under conditions in which the vagi were cut and atropine administered, the responsiveness of nicotine was even further depressed. Combinations either of atropine and chlorpheniramine or atropine and phenoxybenzamine also completely blocked reactions to nicotine. Additionally reactions to nicotine were completely blocked by hexamethonium. These results suggest that nicotine increases both Rc and Rp mainly through a vagal reflex and stimulation of the parasympathetic ganglia.

Ex Output:
Dose-response curves of central and peripheral airways to nicotine injections in dogs.