Detailed Instructions: In this task, you are given a abstract of article and corresponding title of an article. Your task is to generate label "yes" if title is right for article, otherwise generate "no".
Problem:Abstract: Nuclear factor-B (NF-B) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and, similarly to NF-B, blocks apoptosis and induces transformation. This study demonstrates that overexpression of MUC1 in human carcinoma cells is associated with constitutive activation of NF-B p65. We show that MUC1 interacts with the high-molecular-weight IB kinase (IKK) complex in vivo and that the MUC1 cytoplasmic domain binds directly to IKK and IKK. Interaction of MUC1 with both IKK and IKK is necessary for IKK activation, resulting in phosphorylation and degradation of IB. Studies in non-malignant epithelial cells show that MUC1 is recruited to the TNF-R1 complex and interacts with IKKIKK in response to TNF stimulation. TNF-induced recruitment of MUC1 is dependent on TRADD and TRAF2, but not the death-domain kinase RIP1. In addition, MUC1-mediated activation of IKK is dependent on TAK1 and TAB2. These findings indicate that MUC1 is important for physiological activation of IKK and that overexpression of MUC1, as found in human cancers, confers sustained induction of the IKKNF-B p65 pathway.. Title: MUC1 oncoprotein activates the IB kinase complex and constitutive NF-B signalling
Solution:
yes