In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Input: Consider Input: Paragraph: The interferon (IFN-) has been often used as a sensitizing agent for the treatment of various malignancies such as hepatocellular carcinoma, malignant melanoma, and renal cell cancer by promoting the apoptosis of thesetumor cell types. However, the effect of IFN- on cervical cancer remains unknown. In this study, HeLa cells were used as a testing model for the treatment of IFN- on cervical cancer. The results indicate that IFN- markedly inhibits the proliferation and induces the apoptosis of HeLa cells. The activation of caspase 3, the up-regulation of both Bim and cleaved poly (ADP-ribose) polymerase (PARP) 1, the down-regulation of Bcl-xL, as well as the release of cytochrome c from mitochondria were significantly induced upon IFN- treatment, indicating that the intrinsic apoptotic pathway could be activated by IFN- treatment. In addition, caspase 4-which is involved in the endoplasmic reticulum (ER) stress-induced apoptosis-was activated in response to IFN- treatment. Knocking down caspase 4 by small interfering RNA (siRNA) markedly reduced the IFN--mediated cell apoptosis. However, no significant changes in the expressions of caspases 8 and 10 were observed upon IFN- treatment, indicating that the apoptosis caused by IFN- might be independent of the extrinsic apoptotic pathway. These findings suggest that IFN- may possess anti-cervical cancer capacity by activating cell apoptosis via the intrinsic mitochondrial pathway and caspase-4-related ER stress-induced pathway.
Title: Interferon Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway

Output: False

Input: Consider Input: Paragraph: Accumulating evidence suggests that human T cells act as non-classical T cells and contribute to both innate and adaptive immune responses in infections. V2 V2 T (also termed V9 V2 T) cells exist only in primates, and in humans represent a dominant circulating T-cell subset. Primate V2 V2 T cells are the only T cell subset capable of recognizing microbial phosphoantigen. Since nonhuman primate V2 V2 T cells resemble their human counterparts, indepth studies have been undertaken in macaques to understand the biology and function of human V2 V2 T cells. This article reviews the recent progress for immune biology of V2 V2 T cells in infections.
Title: Immune biology of Ag-specific T cells in infections

Output: True

Input: Consider Input: Paragraph: Human Ebola virus causes severe hemorrhagic fever disease with high mortality and there is no vaccine or treatment. Antibodies in survivors occur early, are sustained, and can delay infection when transferred into nonhuman primates. Monoclonal antibodies (mAbs) from survivors exhibit potent neutralizing activity in vitro and are protective in rodents. To better understand targets and mechanisms of neutralization, we investigated a panel of mAbs shown previously to react with the envelope glycoprotein (GP). While one nonneutralizing mAb recognized a GP epitope in the nonessential mucin-like domain, the rest were specific for GP1, were neutralizing, and could be further distinguished by reactivity with secreted GP. We show that survivor antibodies, human KZ52 and monkey JP3K11, were specific for conformation-dependent epitopes comprising residues in GP1 and GP2 and that neutralization occurred by two distinct mechanisms; KZ52 inhibited cathepsin cleavage of GP whereas JP3K11 recognized the cleaved, fusion-active form of GP. Published by Elsevier Inc.
Title: Antibody-mediated neutralization of Ebola virus can occur by two distinct mechanisms
Output: False