TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is s100A8 a novel therapeutic target for anaplastic thyroid carcinoma?
Answer: These findings establish a novel role for S100A8 in the promoting and enhancing of ATC progression. They further suggest that the inhibition of S100A8 could represent a relevant therapeutic target, with the potential of enabling a more effective treatment path for this deadly disease.

SOLUTION: yes

PROBLEM: Question: Is early reduction in number of T cells producing proinflammatory cytokines , observed after extracorporeal photopheresis , linked to apoptosis induction?
Answer: Since proinflammatory cytokines play a major role in the pathology of GvHD, their down-regulation post-ECP may produce a direct clinical benefit. The lowest number of IL2-, IFNgamma- and TNFalpha-expressing T cells occurred within the apoptotic population; however, Annexin V-negative T cells also demonstrated a marked reduction post-ECP. However, the lack of an increase in IL4 and IL10 expression indicates that this process was not a consequence of skewing toward a Th2 cytokine profile.

SOLUTION: no

PROBLEM: Question: Does leptin-mediated reactive oxygen species production significantly affect primary mouse hepatocyte functions in vitro?
Answer: Leptin induced higher ROS levels in primary hepatocytes than in LSECs and HSCs, depending on NADPH oxidase, MEK1 and JAK2 signalling but not on the long leptin receptor isoform. Furthermore, leptin exposure did not influence primary hepatocyte functionality negatively.

SOLUTION:
no