Definition: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: How does the increase in temperature affect the reaction between antigen and antibody?
Options: <1> Increases the reaction rate and decreases binding affinity. <2> It decreases the reaction rate and increases the binding affinity. <3> Increases the reaction rate and binding affinity. <4> Decreases the reaction rate and binding affinity. <5> None of the above options is correct.
Output:
1