Problem: As evident in his imperial edicts, the Hongwu Emperor was well aware of the Buddhist link between Tibet and China and wanted to foster it. Rolpe Dorje, 4th Karmapa Lama (13401383) rejected the Hongwu Emperor's invitation, although he did send some disciples as envoys to the court in Nanjing. The Hongwu Emperor also entrusted his guru Zongluo, one of many Buddhist monks at court, to head a religious mission into Tibet in 13781382 in order to obtain Buddhist texts.
Who rejected an invitation by the Hongwu Emperor?
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Answer: Rolpe Dorje

Problem: Early research into circadian rhythms suggested that most people preferred a day closer to 25 hours when isolated from external stimuli like daylight and timekeeping. However, this research was faulty because it failed to shield the participants from artificial light. Although subjects were shielded from time cues (like clocks) and daylight, the researchers were not aware of the phase-delaying effects of indoor electric lights.[dubious discuss] The subjects were allowed to turn on light when they were awake and to turn it off when they wanted to sleep. Electric light in the evening delayed their circadian phase.[citation needed] A more stringent study conducted in 1999 by Harvard University estimated the natural human rhythm to be closer to 24 hours, 11 minutes: much closer to the solar day but still not perfectly in sync.
What was the fault not considered in the early theories of day length?
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Answer: artificial light

Problem: The European colonization of the Americas forever changed the lives and cultures of the peoples of the continents. Although the exact pre-contact population of the Americas is unknown, scholars estimate that Native American populations diminished by between 80 and 90% within the first centuries of contact with Europeans. The leading cause was disease. The continent was ravaged by epidemics of diseases such as smallpox, measles, and cholera, which were brought from Europe by the early explorers and spread quickly into new areas even before later explorers and colonists reached them. Native Americans suffered high mortality rates due to their lack of prior exposure to these diseases. The loss of lives was exacerbated by conflict between colonists and indigenous people. Colonists also frequently perpetrated massacres on the indigenous groups and enslaved them. According to the U.S. Bureau of the Census (1894), the North American Indian Wars of the 19th century cost the lives of about 19,000 whites and 30,000 Native Americans.
What was the leading cause of death for the native population after European contact?
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Answer:
disease