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Most mutations within genes are neutral, having no effect on the organism's phenotype (silent mutations). Some mutations do not change the amino acid sequence because multiple codons encode the same amino acid (synonymous mutations). Other mutations can be neutral if they lead to amino acid sequence changes, but the protein still functions similarly with the new amino acid (e.g. conservative mutations). Many mutations, however, are deleterious or even lethal, and are removed from populations by natural selection. Genetic disorders are the result of deleterious mutations and can be due to spontaneous mutation in the affected individual, or can be inherited. Finally, a small fraction of mutations are beneficial, improving the organism's fitness and are extremely important for evolution, since their directional selection leads to adaptive evolution.:7.6

What are mutations that lead to amino acid sequence changes but leave the protein functioning similarly called?
Answer: conservative mutations
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After the assassination, Mark Antony formed an alliance with Caesar's adopted son and great-nephew, Gaius Octavian. Along with Marcus Lepidus, they formed an alliance known as the Second Triumvirate. They held powers that were nearly identical to the powers that Caesar had held under his constitution. As such, the Senate and assemblies remained powerless, even after Caesar had been assassinated. The conspirators were then defeated at the Battle of Philippi in 42 BC. Eventually, however, Antony and Octavian fought against each other in one last battle. Antony was defeated in the naval Battle of Actium in 31 BC, and he committed suicide with his lover, Cleopatra. In 29 BC, Octavian returned to Rome as the unchallenged master of the Empire and later accepted the title of Augustus ("Exalted One"). He was convinced that only a single strong ruler could restore order in Rome.

What was the alliance that was formed with Marcus Lepidus named?
Answer: the Second Triumvirate
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New Haven was the host of the 1995 Special Olympics World Summer Games; then-President Bill Clinton spoke at the opening ceremonies. The city is home to the Pilot Pen International tennis event, which takes place every August at the Connecticut Tennis Center, one of the largest tennis venues in the world. New Haven biannually hosts "The Game" between Yale and Harvard, the country's second-oldest college football rivalry. Numerous road races take place in New Haven, including the USA 20K Championship during the New Haven Road Race.

What major tennis event take place annually every August in New Haven?
Answer:
Pilot Pen International