Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

Context: The effect of grape seed indigestible fraction (GSIF) on cecal enzyme activity was studied.', 'Beta-glucuronidase, beta-glucosidase, azoreductase, nitroreductase and nitrate reductase were measured in the cecal content of adult Wistar rats fed with a fiber-free diet supplemented with 5% cellulose or 5% GSIF as the source of dietary fiber for 4 weeks.', 'The intake of GSIF did not affect body weight gain nor food intake. However, GSIF caused a significant increase in cecal content, cecal wall and fresh and dry stool weight. Bacterial enzyme activities were lower in the GSIF-fed group than in the cellulose-fed group, although the difference was also significant for nitroreductase and beta-glucuronidase.
Answer: Adaptation to a diet containing GSIF led to changes in microbial activity that involved a decrease in reductive and hydrolytic enzymatic activities implicated in the conversion of procarcinogens into carcinogens.
Do indigestible components of grape seeds modify cecal enzyme activity in rats?