Q: Fact 1: Disease-causing microbes have a negative impact on the body. Fact 2: Pathogens are microbes that cause disease. Given the two facts above, pathogens do what?

Possible answers:
+ Break down proteins.
+ adapt to environment.
+ influenza orthomyxoviruses.
+ work symbiotically with humans.
+ the immune response.
+ cure disease.
+ have a negative impact on the body.
+ are harmless.
A:
have a negative impact on the body