Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: The Witte Huis (Dutch pronunciation: (t ys)) or White House is a building and National Heritage Site in Rotterdam, Netherlands, built in 1898 in the Art Nouveau style.
[EX A]: The art style of Witte Huis is what?

[EX Q]: Patients with multiple myeloma (MM) experience pathologic fractures, bone pain, hypercalcemia, neurologic symptoms, and renal insufficiency with substantial morbidity and mortality. Bisphosphonates have been used successfully for the management of MM-related bone disease. Increased incidence of osteonecrosis of the jaw has been observed in patients with cancer receiving bisphosphonate therapy. Recent advances in the pathobiology of MM-related bone disease and other cancer-related bone metastases have led to the identification of novel therapeutic targets, such as receptor activator of nuclear factor-kappaB (RANK); its ligand (RANKL); and a decoy receptor, osteoprotegerin, for the development of potential targeted agents. Initials studies have demonstrated that targeting RANK/ RANKL signaling with the fully human monoclonal antibody denosumab prevented skeletal complications in patients with MM and other cancers with bone metastases. Ongoing studies evaluating the clinical utility of denosumab in cancer- related bone destruction have been discussed. In addition, several potential targets, such as macrophage inflammatory protein-1alpha, chemokine receptors 1 and 5, interleukin-3, and Wnt signaling, are b riefly described.
[EX A]: To the ligand of which receptors does Denosumab (Prolia) bind?

[EX Q]: Telescopus hoogstraali, common names of which are Hoogstraal's cat snake and Sinai cat snake, is an endangered species of snake in the family Colubridae.
[EX A]:
How endangered does the iucn consider Telescopus hoogstraali?