the inter-organellar membrane microdomains that are formed between the endoplasmic reticulum (er) and the mitochondria at the opening of the ip3-sensitive ca2+ channel are known as the mitochondria associated-er membranes or mams4,5,6. the protein/lipid composition and biochemical properties of these membrane contact sites have been extensively studied particularly in relation to their role in regulating intracellular ca2+ 4,5,6. the er serves as the primary store of intracellular ca2+, and in this capacity regulates a myriad of cellular processes downstream of ca2+ signaling, including post-translational protein folding and protein maturation7.

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The inter-organellar membrane microdomains that are formed between the endoplasmic reticulum (ER) and the mitochondria at the opening of the IP3-sensitive Ca2+ channel are known as the mitochondria associated-ER membranes or MAMs4,5,6. The protein/lipid composition and biochemical properties of these membrane contact sites have been extensively studied particularly in relation to their role in regulating intracellular Ca2+ 4,5,6. The ER serves as the primary store of intracellular Ca2+, and in this capacity regulates a myriad of cellular processes downstream of Ca2+ signaling, including post-translational protein folding and protein maturation7.