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Serotonin is a neuromodulator involved in regulation of mood and behavior. Development in the limbic system plays an important role in determining rewards and punishments and processing emotional experience and social information. Changes in the levels of the neurotransmitters dopamine and serotonin in the limbic system make adolescents more emotional and more responsive to rewards and stress. The corresponding increase in emotional variability also can increase adolescents' vulnerability. The effect of serotonin is not limited to the limbic system: Several serotonin receptors have their gene expression change dramatically during adolescence, particularly in the human frontal and prefrontal cortex .

Serotonin is a neuromodulator that is involved in regulation of what?
Answer: mood and behavior
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By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.

Who identified the active substance?
Answer: John Abel
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Several MLB teams used to play regular exhibition games during the year against nearby teams in the other major league, but regular-season interleague play has made such games unnecessary. The two Canadian MLB teams, the Toronto Blue Jays of the American League and the Montreal Expos of the National League, met annually to play the Pearson Cup exhibition game; this tradition ended when the Expos moved to Washington DC for the 2005 season. Similarly, the New York Yankees played in the Mayor's Trophy Game against various local rivals from 1946 to 1983.

What game do the Bluejays play against the Expos?
Answer:
the Pearson Cup