instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does apelin-13 protect the heart against ischemia-reperfusion injury through the RISK-GSK-3-mPTP pathway?
Answer: The protective mechanism of apelin-13 might be that inactivation of GSK-3 could inhibit the opening of mPTP by activating PI3K/Akt and ERK1/2 involved in the reperfusion injury salvage kinase (RISK) pathway.
answer:
yes

question:
Question: Are perioperative nonselective non-steroidal anti-inflammatory drugs associated with anastomotic leakage after colorectal surgery?
Answer: There does not appear to be a significant association between perioperative ketorolac use and anastomotic leakage after colorectal surgery. However, further prospective studies are needed to confirm our findings before definitive guidelines on NSAID use perioperatively can be recommended.
answer:
no

question:
Question: Is dorsal plication without degloving safe and effective for correcting ventral penile deformities?
Answer: Penile plication is a safe and effective technique for correcting all directions of curvature. Dorsal plication without degloving produces favorable objective and subjective results comparable to ventral and lateral plication.
answer:
yes