Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Objectives: The aim of this study was to assess the effect of commercial aurintricarboxylic acid (ATA) against Cryptosporidium parvum. Methods: The anticryptosporidial effect of ATA was evaluated in vitro using cell culture and double fluorogenic staining, and in vivo in experimentally infected neonatal C57BL/6 mice. Mice were orally treated for 9 consecutive days starting on the day of infection with daily ATA doses of 50 and 100 mmol/kg. Paromomycin (100 mg/kg) was used as a positive control. Results: In both in vitro models, ATA at concentrations of 100 and 10 mmol/L completely inhibited sporozoites within 10 and 60 min, respectively. Viability of oocysts exposed to 100 mmol/L and assessed by flow cytometry and in cell culture was reduced by 65% and 61%, respectively. The treatment of neonatal mice with a daily ATA dose of 100 mmol/kg led to 97-99% inhibition of infection without any observable negative effects on the animals. In comparison, the mean reduction of infection for paromomycin was 79-84%. Conclusions: ATA exerted high anticryptosporidial activity and should be considered for further study.
Output:
In vitro and in vivo activity of aurintricarboxylic acid preparations against Cryptosporidium parvum