input: Please answer the following: Brad and Henry were two old friends in their 70's. Brad had very high levels of cholesterol, while Henry was healthier and had normal levels of cholesterol. Which friend doesn't take an inhibitor of HMG-CoA reductase? Hint: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem.
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output: Henry

input: Please answer the following: Mike is studying for his physics exam. He realizes that the best way to learn physics is to solve problems. To that end, he needs to to convert pressure of objects from one unit to another. In one problem, four scenarios are given for the same object, scenario A, scenario B, scenario C, and scenario D. In scenario A the pressure is given in Pascals. In scenario B the pressure is given in the atm. In scenario C the pressure is given in torr. Lastly, in scenario D the pressure is given in psi. Which scenario's unit would most likely be used in everyday world, scenario A or scenario D? Hint: Pressures are given in a multitude of units. We've already discussed Pascals, and we know that another unit for pressure is the atmosphere (1 atm = 101.3 x 10 5 Pa). The third commonly used pressure unit is the torr (symbol Torr). 760 torr is 1 atm, but 1 torr is also the increase in pressure necessary to cause liquid mercury to rise by 1 mm. For that reason, torr is also commonly referred to as "millimeters mercury." Another pressure unit commonly used in our everyday world is psi, or pounds per square inch, though neither psi nor torr are SI units.
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output: scenario D

input: Please answer the following: A team of geologists studied two islands. Large island had a lot of seismic activity, and Small island that presented almost no seismic activity. Which island displayed more waves of energy radiating out from an earthquake's focus? Hint: Geologists study earthquake waves to "see" Earth's interior. Waves of energy radiate out from an earthquake's focus. These waves are called seismic waves ( Figure below ). Seismic waves go different speeds through different materials. They change speed when they go from one type of material to another. This causes them to bend. Some seismic waves do not travel through liquids or gases. They just stop. Scientists use information from seismic waves to understand what makes up the Earth's interior.
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output: Large

input: Please answer the following: Jerry and George are two roommates who have lived together since college. They have always gotten along well, have similar hobbies and even are the same height. They both enjoy watching sports and playing videogames, but Jerry also rides his bike several miles each week. George can't stand exercising. Instead, he prefers to lay around relaxing and driving his car if he needs to go somewhere. Is George's BMI higher or lower than Jerry's? Hint: Any unused energy in food, whether it comes from carbohydrates, proteins, or lipids, is stored in the body as fat. An extra 3,500 Calories of energy results in the storage of almost half a kilogram (1 pound) of stored body fat. People who consistently consume more food energy then they need may become obese. Obesity occurs when the body mass index is 30.0 kg/m 2 or greater. Body mass index (BMI) is an estimate of the fat content of the body. It is calculated by dividing a person's weight (in kilograms) by the square of the person's height (in meters). Obesity increases the risk of health problems such as type 2 diabetes and hypertension.
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output:
higher