Detailed Instructions: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Problem:disease. Since 2012, the victims have mainly come from the Middle East countries or sporadically from some other geographical regions seeded by the travelers who visited the Middle East. Such an introduction through travelling led to the emergence of a MERS-CoV outbreak in Korea in May 2015, which caused more than 140 confirmed human cases in less than a month. Using 70 complete genome sequences of MERS-CoV isolates, including the most recent sequences for the Korean and Chinese isolates, we reconstructed the phylogenetic relationships of the complete genome and the individual protein coding regions. The Korean MERS-CoV strain clustered in the previously established Hafr-Al-Batin-1_2013 clade together with two Saudi Arabian and one Chinese strain sampled in 2015. Although these four strains remained monophyletic in the entire protein-coding region, this clade showed different phylogenetic relationships across the genome, indicating a shared unique recombination pattern that is different from previously reported putative recombination strains. Our findings suggest that the recent ancestor of the Korean and its related MERS-CoV strains is characterized by unique mosaic genome pattern that is different from other putative recombinants. MERS was first described in 2012 in fatal human cases that were caused by a single-stranded RNA coronavirus 1-3 . Since then, more than 1,000 cases of MERS-CoV infection have been confirmed with an estimated case-fatality rate (CFR) of 39.5% 4 , and the elderly and immunocompromised patients appear to be most severely affected 5 . Acute respiratory distress and pneumonia are the major clinical manifestations of MERS-CoV infection 6 . Gastrointestinal symptoms and renal failure are also reported in some cases 5, 7 . Dromedary camels are considered to be the intermediate host in MERS zoonotic transmission chains from bats to humans 8, 9 . In a previously published study, the spread of MERS-CoV appeared to match transmission routes between animal reservoirs and infected humans 10 . However, it was not readily replicated in a camel transmission study 11 . Despite this contradiction, MERS-CoV spread was
Solution:
Scientific RepoRts | 6:18825 | of Korea. 12 The MERS Task Force of the