Detailed Instructions: In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
Problem:Paragraph: Inhalation of Saccharopolyspora rectivirgula causes "farmer's lung" disease, a classic example of hypersensitivity pneumonitis (HP). Monocyte chemoattractant protein-1 (MCP-1) is increased in the bronchoalveolar lavage fluid of mice challenged with S rectivirgula, and S rectivirgula induces MCP-1 secretion by alveolar macrophages. We tested the hypothesis that MCP-1 and its receptor CC chemokine receptor-2 (CCR2) are essential to the development of experimental HP by treating mice with MCP-1 antibody and using CCR2 / mice. Administration of anti-MCP-1 did not change the response to intratracheally administered S rectivirgula. CCR2 / animals responded in a fashion similar to that of wild-type animals to intratracheally administered.S rectivirgula. To determine the influence of the MCP-1-CCR2 interaction in vitro, we transferred S rectivirgula-cultured spleen cells from S rectivirgulasensitized mice, to naive recipients. Later, challenge of the recipients with intratracheal S rectivirgula and examination of both lung histology and bronchoalveolar lavage fluid characteristics were used to determine whether adoptive transfer had occurred. We found that cultured cells from CCR2 / animals were fully capable of adoptive transfer. We conclude that interaction of MCP-1 with CCR2 is not necessary for the development of pulmonary inflammation in response to intratracheally administered S rectivirgula or cells able to adoptively transfer experimental HP. (J Lab Clin Med 2003;142:187-95) Abbreviations: ANOVA analysis of variance; BALF bronchoalveolar lavage fluid; CCR2 CC chemokine receptor-2; EHP experimental hypersensitivity pneumonitis; FLD "farmer's lung" disease; HEPA high-efficiency particulate air; HP hypersensitivity pneumonitis; HSD honestly significant difference; IFN- interferon-; IL interleukin; MCP monocyte chemoattractant protein; MIP-1 macrophage inflammatory protein-1; SEM standard error of the mean; Th T-helper; TNF tumor necrosis factor
Title: Experimental hypersensitivity pneumonitis: Role of MCP-1
Solution:
False