instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients.
answer:
Which gene is involved in CADASIL?

question:
It is unanimously accepted that there is an unmet need for pain medications that are both effective and safe. Unfortunately, no really novel analgesics have been approved over the past three decades. In view of both experimental and clinical evidence of a major role for nerve growth factor (NGF) in the generation and maintenance of a wide range of pain states, drug discovery efforts focusing on the development of anti-NGF agents have aroused particular interest. Several humanized anti-NGF monoclonal antibodies (mAbs) have entered clinical trials as potential analgesics. In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for pain, reviewing the analgesic efficacy and safety of anti-NGF agents based on data from fully published studies, conference abstracts, and the US Food and Drug Administration (FDA) website, and discussing the possible future of these agents in managing chronic pain. Anti-NGF mAbs produced significant pain relief and functional improvement in patients with osteoarthritis of the knee and/or hip. Conversely, studies in non-specific lower back pain generated mixed results; overall, this condition appeared to be less responsive to anti-NGF agents than osteoarthritis. Finally, there was no conclusive evidence of the effectiveness of anti-NGF mAbs in some types of chronic visceral or neuropathic pain. Furthermore, these studies raised safety concerns about anti-NGF mAbs. As a class, these drugs may cause or worsen peripheral neuropathies. But the most problematic issue-which prompted the FDA to place studies of these compounds on clinical hold in 2010-was rapid joint destruction leading to joint replacement surgery. The aetiologies of these side effects have been much debated and their pathophysiology is poorly understood. After an Arthritis Advisory Committee meeting held in March 2012, pharmaceutical companies negotiated with the FDA on the conditions for restarting clinical studies. Although the FDA lifted its clinical hold, there remain many unresolved issues about the long-term efficacy and safety of anti-NGF mAbs. While acknowledging that the future of these drugs is unforeseeable, it appears that they may not be the safe and effective painkillers that have been awaited for decades.
answer:
What is the target of tanezumab?

question:
Vitamins and minerals are also nutrients. They do not provide energy, but they are needed for good health. Vitamins are organic compounds that the body needs in small amounts to function properly. Humans need 13 different vitamins. Some of them are listed below ( Table 1.1). The table also shows how much of each vitamin you need every day. Vitamins have many roles in the body. For example, Vitamin A helps maintain good vision. Vitamin B9 helps form red blood cells. Vitamin K is needed for blood to clot when you have a cut or other wound. Vitamin Necessary for Available from Daily Amount Required (at ages 913 years) Vitamin Necessary for Available from A Good vision B1 Healthy nerves B3 Healthy skin and nerves B9 Red blood cells B12 Healthy nerves C Growth and repair of tis- sues Healthy bones and teeth Blood to clot Carrots, spinach, milk, eggs Whole wheat, peas, meat, beans, fish, peanuts Beets, liver, pork, turkey, fish, peanuts Liver, peas, dried beans, leafy green vegetables Meat, liver, milk, shell- fish, eggs Oranges, grapefruits, red peppers, broccoli Milk, salmon, tuna, eggs Spinach, brussels sprouts, milk, eggs D K Daily Amount Required (at ages 913 years) 600 g (1 g = 1 106 g) 0.9 mg (1 mg = 1 103 g) 12 mg 300 g 1.8 g 45 mg 5 g 60 g Some vitamins are produced in the body. For example, vitamin D is made in the skin when it is exposed to sunlight. Vitamins B12 and K are produced by bacteria that normally live inside the body. Most other vitamins must come from foods. Foods that are good sources of vitamins include whole grains, vegetables, fruits, and milk ( Table 1.1). Not getting enough vitamins can cause health problems. For example, too little vitamin C causes a disease called scurvy. People with scurvy have bleeding gums, nosebleeds, and other symptoms. Minerals are chemical elements that are needed for body processes. Minerals that you need in relatively large amounts are listed below ( Table 1.2). Minerals that you need in smaller amounts include iodine, iron, and zinc. Minerals have many important roles in the body. For example, calcium and phosphorus are needed for strong bones and teeth. Potassium and sodium are needed for muscles and nerves to work normally. Mineral Necessary for Available from Calcium Strong bones and teeth Chloride Magnesium Proper balance of water and salts in body Strong bones Phosphorus Strong bones and teeth Potassium Muscles and nerves to work normally Muscles and nerves to work normally Milk, soy milk, leafy green vegetables Table salt, most packaged foods Whole grains, leafy green vegetables, nuts Meat, poultry, whole grains Meats, grains, bananas, orange juice Table salt, most packaged foods Sodium Daily Amount Required (at ages 913 years) 1,300 mg 2.3 g 240 mg 1,250 mg 4.5 g 1.5 g Your body cannot produce any of the minerals that it needs. Instead, you must get minerals from the foods you eat. Good sources of minerals include milk, leafy green vegetables, and whole grains ( Table 1.2). Not getting enough minerals can cause health problems. For example, too little calcium may cause osteoporosis. This is a disease in which bones become soft and break easily. Getting too much of some minerals can also cause health problems. Many people get too much sodium. Sodium is added to most packaged foods. People often add more sodium to their food by using table salt. Too much sodium causes high blood pressure in some people.
answer:
what vitamin is important in blood clotting?