Given the task definition, example input & output, solve the new input case.
Given a scientific passage and an answer, generate a question for the given answer.
Example: Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Output: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.

New input case for you: Passage: Mutation creates new genetic variation in a gene pool. It is how all new alleles first arise. In sexually reproducing species, the mutations that matter for evolution are those that occur in gametes. Only these mutations can be passed to offspring. For any given gene, the chance of a mutation occurring in a given gamete is very low. Thus, mutations alone do not have much effect on allele frequencies. However, mutations provide the genetic variation needed for other forces of evolution to act. Answer: mutation
Output:
What phenomenon, crucial for evolution, creates new genetic variation in a gene pool and is how all new alleles first arise?