Given the task definition and input, reply with output. In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: What effect would chromatin have on neutralizing the positive charge of histones ?:
Options: <1> The DNA would change charge. <2> Histones would bind more closely to DNA. <3> The DNA would be supercoiled. <4> The histones would separate from the DNA. <5> The histones would be grouped together.
4