Premise: I felt awful.

Hypothesis: I felt fantastic.
Answer: no

Premise: Yet, we remain concerned that the proposed transfer of control and priority setting for research from the organizations where the research would be conducted could be disruptive to dual purpose programs, which have important synergies for public health programs that need to be maintained.

Hypothesis: We remain concerned that the proposed transfer of control and priority setting for research from the organizations where the research would be conducted could be disruptive to dual purpose programs.
Answer: yes

Premise: So did mine, but I saw nothing helpful.

Hypothesis: My mail arrived on time too but nothing helpful came.
Answer: it is not possible to tell

Premise: I'm being serious with you, now give me a serious answer.

Hypothesis: I am serious that I want a serious answer from you.
Answer: yes