Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.
[EX A]: Which is the receptor for substrates of Chaperone Mediated Autophagy?

[EX Q]: The overlap between symptoms of PTSD and MDD is substantial. PTSD symptoms arise after a traumatic experience and the trauma is present in all of the diagnostic clusters. In individuals who have experienced a trauma a long time before, it is difficult to establish the exact moment of onset of their symptoms in relation to the trauma suffered. We proposed to raise awareness among operators who may encounter this problem, with the aim of providing them with valuable help in order to achieve a correct differential diagnosis. A sample of subjects suffering from PTSD without comorbidity was assessed to confirm the diagnosis and the severity of post-traumatic symptoms. The Kruskal-Wallis test was used to compare any modifications in the parameters analyzed through the Davidson Trauma Scale with the presence and severity of depressive symptoms as evaluated by the Hamilton-D scale. Half of the PSTD patients recruited showed values of HAM-D > 18, although an active Major Depressive Episode was clinically excluded. Symptom of "numbing", despite being different from the apathy experienced in depression, is identified as a depressive symptom by the HAM-D. Giving prevalence to depressive symptoms may be misleading for diagnosis and may ultimately result in inappropriate treatment.
[EX A]: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?

[EX Q]: Some aquifers are overused; people pump out more water than is replaced. As the water is pumped out, the water table slowly falls, requiring wells to be dug deeper, which takes more money and energy. Wells may go completely dry if they are not deep enough to reach into the lowered water table. Other problems may stem from groundwater overuse. Subsidence and saltwater intrusion are two of them. The Ogallala Aquifer supplies about one-third of the irrigation water in the United States. The Ogallala Aquifer is widely used by people for municipal and agricultural needs. (Figure 1.2). The aquifer is found from 30 to 100 meters deep over an area of about 440,000 square kilometers! The water in the aquifer is mostly from the last ice age. About eight times more water is taken from the Ogallala Aquifer each year than is replenished. Much of the water is used for irrigation (Figure 1.3). Click image to the left or use the URL below. URL: Intense drought has reduced groundwater levels in the southern U.S., particularly in Texas and New Mexico. Lowering the water table may cause the ground surface to sink. Subsidence may occur beneath houses and other structures (Figure 1.4). When coastal aquifers are overused, salt water from the ocean may enter the aquifer, contaminating the aquifer and making it less useful for drinking and irrigation. Salt water incursion is a problem in developed coastal regions, such as on Hawaii.
[EX A]:
this aquifer supplies one-third of the irrigation water in the united states.