Problem: Additionally, genes can have regulatory regions many kilobases upstream or downstream of the open reading frame. These act by binding to transcription factors which then cause the DNA to loop so that the regulatory sequence (and bound transcription factor) become close to the RNA polymerase binding site. For example, enhancers increase transcription by binding an activator protein which then helps to recruit the RNA polymerase to the promoter; conversely silencers bind repressor proteins and make the DNA less available for RNA polymerase.
What causes DNA to be less available for RNA polymerase?
The answer is the following: silencers bind repressor proteins

New claims on Antarctica have been suspended since 1959 although Norway in 2015 formally defined Queen Maud Land as including the unclaimed area between it and the South Pole. Antarctica's status is regulated by the 1959 Antarctic Treaty and other related agreements, collectively called the Antarctic Treaty System. Antarctica is defined as all land and ice shelves south of 60 S for the purposes of the Treaty System. The treaty was signed by twelve countries including the Soviet Union (and later Russia), the United Kingdom, Argentina, Chile, Australia, and the United States. It set aside Antarctica as a scientific preserve, established freedom of scientific investigation and environmental protection, and banned military activity on Antarctica. This was the first arms control agreement established during the Cold War.
Since what year have claims been suspended in Antarctica?
1959

Input: Elizabeth II
In 1943, at the age of 16, Elizabeth undertook her first solo public appearance on a visit to the Grenadier Guards, of which she had been appointed colonel the previous year. As she approached her 18th birthday, parliament changed the law so that she could act as one of five Counsellors of State in the event of her father's incapacity or absence abroad, such as his visit to Italy in July 1944. In February 1945, she joined the Women's Auxiliary Territorial Service as an honorary second subaltern with the service number of 230873. She trained as a driver and mechanic and was promoted to honorary junior commander five months later.

At what age was Elizabeth when she went on her first solo public appearance?
Output: 16

Input: Article: From their beginnings in Sumer (now Iraq) around 3500 BC, the Mesopotamian people began to attempt to record some observations of the world with numerical data. But their observations and measurements were seemingly taken for purposes other than for elucidating scientific laws. A concrete instance of Pythagoras' law was recorded, as early as the 18th century BC: the Mesopotamian cuneiform tablet Plimpton 322 records a number of Pythagorean triplets (3,4,5) (5,12,13). ..., dated 1900 BC, possibly millennia before Pythagoras, but an abstract formulation of the Pythagorean theorem was not.

Now answer this question: Which tablet had Pythagorean triplets on it?

Output: Plimpton 322

Article: The U.S. Social Security Administration (SSA), which oversees the world's largest administrative judicial system under its Office of Disability Adjudication and Review (ODAR), has made extensive use of videoconferencing to conduct hearings at remote locations. In Fiscal Year (FY) 2009, the U.S. Social Security Administration (SSA) conducted 86,320 videoconferenced hearings, a 55% increase over FY 2008. In August 2010, the SSA opened its fifth and largest videoconferencing-only National Hearing Center (NHC), in St. Louis, Missouri. This continues the SSA's effort to use video hearings as a means to clear its substantial hearing backlog. Since 2007, the SSA has also established NHCs in Albuquerque, New Mexico, Baltimore, Maryland, Falls Church, Virginia, and Chicago, Illinois.

Question: In what year did the SSA see a 55% increase in videoconferenced hearings?
Ans: 2009

Input: Immaculate Conception
The defined dogma of the Immaculate Conception regards original sin only, saying that Mary was preserved from any stain (in Latin, macula or labes, the second of these two synonymous words being the one used in the formal definition). The proclaimed Roman Catholic dogma states "that the most Blessed Virgin Mary, in the first instance of her conception, by a singular grace and privilege granted by Almighty God, in view of the merits of Jesus Christ, the Saviour of the human race, was preserved free from all stain of original sin." Therefore, being always free from original sin, the doctrine teaches that from her conception Mary received the sanctifying grace that would normally come with baptism after birth.

What was the outcome of preventing Mary from having to endure such an injustice ?
Output:
Jesus Christ, the Saviour of the human race, was preserved free from all stain of original sin."