Problem: Czech language:

Bohemia (as Czech civilization was known by then) increased in power over the centuries, as its language did in regional importance. This growth was expedited during the fourteenth century by Holy Roman Emperor Charles IV, who founded Charles University in Prague in 1348. Here, early Czech literature (a biblical translation, hymns and hagiography) flourished. Old Czech texts, including poetry and cookbooks, were produced outside the university as well. Later in the century Jan Hus contributed significantly to the standardization of Czech orthography, advocated for widespread literacy among Czech commoners (particularly in religion) and made early efforts to model written Czech after the spoken language.

When was Charles University founded in Prague?
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A: 1348

Problem: Botany:

20th century developments in plant biochemistry have been driven by modern techniques of organic chemical analysis, such as spectroscopy, chromatography and electrophoresis. With the rise of the related molecular-scale biological approaches of molecular biology, genomics, proteomics and metabolomics, the relationship between the plant genome and most aspects of the biochemistry, physiology, morphology and behaviour of plants can be subjected to detailed experimental analysis. The concept originally stated by Gottlieb Haberlandt in 1902 that all plant cells are totipotent and can be grown in vitro ultimately enabled the use of genetic engineering experimentally to knock out a gene or genes responsible for a specific trait, or to add genes such as GFP that report when a gene of interest is being expressed. These technologies enable the biotechnological use of whole plants or plant cell cultures grown in bioreactors to synthesise pesticides, antibiotics or other pharmaceuticals, as well as the practical application of genetically modified crops designed for traits such as improved yield.

What opened the door to plant genetic engineering?
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A: all plant cells are totipotent

Problem: Crimean War:

Sevastopol fell after eleven months, and formerly neutral countries began to join the allied cause. Isolated and facing a bleak prospect of invasion from the west if the war continued, Russia sued for peace in March 1856. This was welcomed by France and the UK, where the citizens began to turn against their governments as the war dragged on. The war was officially ended by the Treaty of Paris, signed on 30 March 1856. Russia lost the war, and was forbidden from hosting warships in the Black Sea. The Ottoman vassal states of Wallachia and Moldavia became largely independent. Christians were granted a degree of official equality, and the Orthodox church regained control of the Christian churches in dispute.:415

Who wanted peace when they feared of being invaded from the west?
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A: Russia

Problem: Pharmaceutical industry:

During the years 1940-1955, the rate of decline in the U.S. death rate accelerated from 2% per year to 8% per year, then returned to the historical rate of 2% per year. The dramatic decline in the immediate post-war years has been attributed to the rapid development of new treatments and vaccines for infectious disease that occurred during these years. Vaccine development continued to accelerate, with the most notable achievement of the period being Jonas Salk's 1954 development of the polio vaccine under the funding of the non-profit National Foundation for Infantile Paralysis. The vaccine process was never patented, but was instead given to pharmaceutical companies to manufacture as a low-cost generic. In 1960 Maurice Hilleman of Merck Sharp & Dohme identified the SV40 virus, which was later shown to cause tumors in many mammalian species. It was later determined that SV40 was present as a contaminant in polio vaccine lots that had been administered to 90% of the children in the United States. The contamination appears to have originated both in the original cell stock and in monkey tissue used for production. In 2004 the United States Cancer Institute announced that it had concluded that SV40 is not associated with cancer in people.

Who announced that SV40 was not associated with cancer?
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A:
United States Cancer Institute