Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: The DRG Class 99.19 engines were metre gauge, ten-coupled, superheated, steam locomotives that were employed in the southwestern German state of Wurttemberg from 1927.
[EX A]: What was the year that DRG Class 99.19 entered service?

[EX Q]: NASCAR Thunder 2002 is a racing simulator video game developed by EA Tiburon and published by EA Sports that came out for the Sony PlayStation, Sony PlayStation 2, and Xbox.
[EX A]: Who worked on NASCAR Thunder 2002?

[EX Q]: Hypospadias, when the urethra opens on the ventral side of the penis, is a common malformation seen in about 3 per 1,000 male births. It is a complex disorder associated with genetic and environmental factors and can be part of genetic syndromes. Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by a distinct facial phenotype, Hirschsprung disease, microcephaly and mental retardation. It is caused by mutations in the zinc finger homeo box 1B gene, ZFHX1B (SIP1). To date, 68 deletion/mutation-positive cases have been reported. Genitourinary anomalies are common in MWS. Here we report that hypospadias is common in males with this syndrome. In 39 patients where this information was available, hypospadias was present in 46% of patients (18/39). In the 3 Italian male cases reported here, hypospadias was always present. MWS should be considered by endocrinologists in patients with hypospadias associated with developmental delays/mental retardation, in particular in the presence of a distinct facial phenotype.
[EX A]:
Which gene is responsible for the development of the Mowat-Wilson syndrome?