instruction:
Given a text passage, come up with an appropriate title for it. The title should accurately represent what the main focus of the passage is. The title of a passage may be present in the first few sentences of the passage and/or be referred to multiple times in the passage. The title should be 1-5 words long.
question:
Frankenstein is written in the form of a frame story that starts with Captain Robert Walton writing letters to his sister . It takes place at an unspecified time in the 18th century , as the letters ' dates are given as '' 17 -- '' .
answer:
Frankenstein

question:
I Am Number Four is a young adult science fiction novel by Pittacus Lore ( the pseudonym of James Frey and Jobie Hughes ) and the first book in the Lorien Legacies series . The book was published by HarperCollins on August 3 , 2010 , and spent seven successive weeks at # 1 on the children 's chapter of the New York Times bestseller list .
answer:
I Am Number Four

question:
Down syndrome is one of the most common chromosome abnormalities in humans . It occurs in about one per 1000 babies born each year . In 2015 , Down syndrome was present in 5.4 million individuals and resulted in 27,000 deaths down from 43,000 deaths in 1990 . It is named after John Langdon Down , the British doctor who fully described the syndrome in 1866 . Some aspects of the condition were described earlier by Jean - Etienne Dominique Esquirol in 1838 and Edouard Seguin in 1844 . In 1957 , the genetic cause of Down syndrome , an extra copy of chromosome 21 , was discovered .
answer:
Down syndrome