TASK DEFINITION: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
PROBLEM: The recent outbreak of the human Zaire ebolavirus (EBOV) epidemic is spiraling out of control in West Africa. Human EBOV hemorrhagic fever has a case fatality rate of up to 90%. The EBOV is classified as a biosafety level 4 pathogen and is considered a category A agent of bioterrorism by Centers for Disease Control and Prevention, with no approved therapies and vaccines available for its treatment apart from supportive care. Although several promising therapeutic agents and vaccines against EBOV are undergoing the Phase I human trial, the current epidemic might be outpacing the speed at which drugs and vaccines can be produced. Like all viruses, the EBOV largely relies on host cell factors and physiological processes for its entry, replication, and egress. We have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal studies. Most of the therapeutic agents in this review are directed against non-mutable targets of the host, which is independent of viral mutation. These medications are approved by the Food and Drug Administration (FDA) for the treatment of other diseases. They are available and stockpileable for immediate use. They may also have a complementary role to those therapeutic agents under development that are directed against the mutable targets of the EBOV.

SOLUTION: Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus-mutable host cell therapeutic targets for Ebola virus, Cocktail therapeutic intervention for RNA virus Multilingual abstract

PROBLEM: BackgroundDetection and characterization of viral RNA pathogens from fieldwork are challenging due to the instability of the RNA molecule. FTA cards®️ have proved useful for sample storage and latter identification of pathogens with importance for agricultural, animal and human health: however, for optimal handling, processing, and biosafety measures are not well-established. ObjectiveThis systematic review aims to summarize the reported effectiveness of FTA cards®️ for storage and transport of viral RNA, as well as the conditions for their handling and use in downstream processes. Finally, the biosafety measures required to protect researchers and clinical lab workers are considered. MethodsWe performed a systematic review following the PRISMA statement. We searched MEDLINE (PubMed), Scopus and Web of Science using the keywords "FTA cards" AND "RNA". Articles were screened by title and abstract, and after examination of inclusion and exclusion criteria, relevant information was extracted. The quality of the studies was assessed, and the evidence was qualitatively summarized. ResultsA total of 175 records were retrieved, and 11 additional documents were found by checking references of the eligible articles. A total of 47 articles were included. Samples from animals accounted for 38.3% of the publications, which identified viruses that cause disease in poultry, wild birds, suids, or bovids. Three different methods for RNA extraction were reported. Other factors that vary across reports include the size of RNA amplicon, storage temperature, and duration of storage. Only fourteen articles tested the inactivation of the virus on the FTA card®️, and in one case, the virus remained infective. ConclusionFTA cards®️ could be a suitable option for RNA virus storage and transport for fieldwork in areas where proper conditions for RNA preservation are difficult to achieve. Three different protocols have been used for RNA detection from this matrix. Biospecimens in the form of dried blood spots should be considered potentially infectious unless specifically treated to inactivate viral pathogens. technology consists of filter paper impregnated with a patented chemical mixture that contains chemical denaturants and a free radical scavenger. The chemical mixture lyses cells and organelles, prevents overgrowth of bacteria, and denatures proteins. The DNA is captured in the matrix and remains tightly bound while proteins and inhibitors are washed. This keeps DNA stable during long-term storage at room temperature (GE Healthcare, 2019).

SOLUTION: A systematic review of FTA cards®️ as a tool for viral RNA preservation in fieldwork: Are they safe and effective?

PROBLEM: Food security in the Middle East is directly affected by a challenging combination of ongoing destructive conflicts, a global economic downturn, widespread poverty, high population growth, corruption, intolerance, and the potentially damaging consequences of climate change. Many Arab countries demonstrate nearly all the features of those countries classified as poor, less developed, or failing to achieve the eight Millennium Goals. Even the economies of the richer oil-exporting countries in the Region have been seriously damaged by the downturn in oil and gas prices as new sources come on stream elsewhere and demand falls as a result of renewable sources of energy becoming available. Climate change predictions for the Region are worrisome even if most of the environmental commitments made by countries at the UN Climate Change Conference in Paris at the end of 2015 are delivered. Large parts of the Region already suffer from periods of extreme temperatures and shortages of fresh water, so harsher conditions of higher temperatures and weather extremes pose special problems for inhabitants and policymakers, with heightened geopolitical risks and uncertainties. Agriculture is especially vulnerable. Modern agricultural technologies with improved cultivars and livestock breeds must displace poor agricultural and pastoral practices. Larger-scale, bettercapitalised production units are required with policy shifts to remove marketdistorting subsidies, tariffs, and other regulatory impedances. Agricultural "roadmaps" are needed to encourage the most appropriate crops and maintain livestock in the most appropriate places. The trading of meat, dairy products and many types of crops to water-poor regions can be regarded as an efficient way to 261 redistribute water. In unsettled times, food security requires protection of foodproducing, food-processing, and food-distribution industries are protected along with research and development facilities, and the maintenance of skilled personnel. There are doubts as to whether agencies of the United Nations, other international agencies, donor countries and charities are able to provide adequate humanitarian aid and humanitarian intervention to enable safeguarding of displaced peoples and ensuring the resumption of normal peaceful conditions essential for food security to be guaranteed. Promises of aid funds must become reality, followed by the establishment of functional supply and transport networks, and rapid transition to self-reliance thereafter. Food security and social stability are inextricably linked. The solution to the food-security problems in the Region ultimately lies in the actions of governments, businesses and individuals. Governments need embedded scientific and technological expertise, strong civil-society institutions, integrity, and a particular focus on high-quality education.

SOLUTION:
Food Security in an Insecure Future