Question: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.
Try to answer this question if possible: Who discovered mevastatin?
Answer: Akira Endo
Question: Relations between the Rus' and Byzantines became more complex after Oleg took control over Kiev, reflecting commercial, cultural, and military concerns. The wealth and income of the Rus' depended heavily upon trade with Byzantium. Constantine Porphyrogenitus described the annual course of the princes of Kiev, collecting tribute from client tribes, assembling the product into a flotilla of hundreds of boats, conducting them down the Dnieper to the Black Sea, and sailing to the estuary of the Dniester, the Danube delta, and on to Constantinople. On their return trip they would carry silk fabrics, spices, wine, and fruit. The importance of this trade relationship led to military action when disputes arose. The Primary Chronicle reports that the Rus' attacked Constantinople again in 907, probably to secure trade access. The Chronicle glorifies the military prowess and shrewdness of Oleg, an account imbued with legendary detail. Byzantine sources do not mention the attack, but a pair of treaties in 907 and 911 set forth a trade agreement with the Rus', the terms suggesting pressure on the Byzantines, who granted the Rus' quarters and supplies for their merchants and tax-free trading privileges in Constantinople.
Try to answer this question if possible: What was written about Rus in 907?
Answer: unanswerable
Question: In free-range husbandry, the birds can roam freely outdoors for at least part of the day. Often, this is in large enclosures, but the birds have access to natural conditions and can exhibit their normal behaviours. A more intensive system is yarding, in which the birds have access to a fenced yard and poultry house at a higher stocking rate. Poultry can also be kept in a barn system, with no access to the open air, but with the ability to move around freely inside the building. The most intensive system for egg-laying chickens is battery cages, often set in multiple tiers. In these, several birds share a small cage which restricts their ability to move around and behave in a normal manner. The eggs are laid on the floor of the cage and roll into troughs outside for ease of collection. Battery cages for hens have been illegal in the EU since January 1, 2012.
Try to answer this question if possible: What is yarding in relation to the pultry industry?
Answer: birds have access to a fenced yard and poultry house at a higher stocking rate
Question: Miami and its suburbs are located on a broad plain between the Florida Everglades to the west and Biscayne Bay to the east, which also extends from Florida Bay north to Lake Okeechobee. The elevation of the area never rises above 40 ft (12 m) and averages at around 6 ft (1.8 m) above mean sea level in most neighborhoods, especially near the coast. The highest undulations are found along the coastal Miami Rock Ridge, whose substrate underlies most of the eastern Miami metropolitan region. The main portion of the city lies on the shores of Biscayne Bay which contains several hundred natural and artificially created barrier islands, the largest of which contains Miami Beach and South Beach. The Gulf Stream, a warm ocean current, runs northward just 15 miles (24 km) off the coast, allowing the city's climate to stay warm and mild all year.
Try to answer this question if possible: Where aren't the Everglades in relation to Miami?
Answer:
unanswerable