In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.
Q: Context: Genome-wide association studies have identified single-nucleotide polymorphisms at the 10q11 locus as risk factors for myocardial infarction (MI). This locus lies upstream (80kb) of the stromal cell-derived factor-1 (SDF1) gene that codify for a chemokine with protective atherogenetic effects and with a major role in the mobilization, homing, and differentiation of endothelial progenitor cells (EPCs). The purpose of this study was to investigate the possible association of SDF1-3'A polymorphism, that upregulates SDF1 protein expression, with MI and early endothelial dysfunction and atherosclerosis in young healthy subjects.", "200 patients (181 men age 57.37.7 years) and 230 healthy controls (96 men, age 5211.9 years) were recruited to investigate the association between MI and SDF1-3'A polymorphism. The relationship between SDF1-3'A polymorphism and brachial artery flow-mediated dilation and the number of circulating EPCs was examined in 50 healthy young adults.", "A significant difference in SDF1-3'A genotype distribution was observed between patients and controls (P=0.006). Patients carrying the A allele had a significantly reduced MI risk compared with subjects with GG genotype (odds ratio=0.5, 95% CI=0.3-0.9, P=0.001). SDF1-3'A polymorphism presented a significant interaction with other cardiovascular risk factors (Pinteraction<0. 0001). Controls carrying the A allele showed significantly higher flow-mediated dilation (13.94.9 vs 10.84.3, P=0.03) and significantly higher values of EPCs (0.0290.009 vs 0.0220.008, P=0.02) compared with GG homozygotes.\Question: Is stromal cell-derived factor-1-3 ' A polymorphism associated with decreased risk of myocardial infarction and early endothelial disturbance?
A:
SDF1-3'A polymorphism is associated with a decreased risk of MI and early endothelial dysfunction, strongly confirming the important atherogenic role of SDF1 gene at clinical level.