Problem: Antibiotics:

Antibiotics are screened for any negative effects on humans or other mammals before approval for clinical use, and are usually considered safe and most are well tolerated. However, some antibiotics have been associated with a range of adverse side effects. Side-effects range from mild to very serious depending on the antibiotics used, the microbial organisms targeted, and the individual patient. Side effects may reflect the pharmacological or toxicological properties of the antibiotic or may involve hypersensitivity reactions or anaphylaxis. Safety profiles of newer drugs are often not as well established as for those that have a long history of use. Adverse effects range from fever and nausea to major allergic reactions, including photodermatitis and anaphylaxis. Common side-effects include diarrhea, resulting from disruption of the species composition in the intestinal flora, resulting, for example, in overgrowth of pathogenic bacteria, such as Clostridium difficile. Antibacterials can also affect the vaginal flora, and may lead to overgrowth of yeast species of the genus Candida in the vulvo-vaginal area. Additional side-effects can result from interaction with other drugs, such as elevated risk of tendon damage from administration of a quinolone antibiotic with a systemic corticosteroid. Some scientists have hypothesized that the indiscriminate use of antibiotics alter the host microbiota and this has been associated with chronic disease.

Name some adverse effects?
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A: fever and nausea to major allergic reactions, including photodermatitis and anaphylaxis

Problem: Indigenous peoples of the Americas:

The first indigenous group encountered by Columbus were the 250,000 Tainos of Hispaniola who represented the dominant culture in the Greater Antilles and the Bahamas. Within thirty years about 70% of the Tainos had died. They had no immunity to European diseases, so outbreaks of measles and smallpox ravaged their population. Increasing punishment of the Tainos for revolting against forced labour, despite measures put in place by the encomienda, which included religious education and protection from warring tribes, eventually led to the last great Taino rebellion.

Who was the first group of indigenous people Columbus encountered?
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A: the 250,000 Tainos of Hispaniola

Problem: Raleigh, North Carolina:

In the late nineteenth century, two black Congressmen were elected from North Carolina's 2nd district, the last in 1898. George Henry White sought to promote civil rights for blacks and to challenge efforts by white Democrats to reduce black voting by new discriminatory laws. They were unsuccessful. In 1900, the state legislature passed a new constitution, with voter registration rules that disfranchised most blacks and many poor whites. The state succeeded in reducing black voting to zero by 1908. Loss of the ability to vote disqualified black men (and later women) from sitting on juries and serving in any office, local, state or federal. The rising black middle-class in Raleigh and other areas was politically silenced and shut out of local governance, and the Republican Party was no longer competitive. It was not until after federal civil rights legislation was passed in the mid-1960s that the majority of blacks in North Carolina would again be able to vote, sit on juries and serve in local offices. No African American was elected to Congress until 1992.

When was the last time two black congressmen were elected?
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A: 1898

Problem: East India Company:

With the advent of the Industrial Revolution, Britain surged ahead of its European rivals. Demand for Indian commodities was boosted by the need to sustain the troops and the economy during the war, and by the increased availability of raw materials and efficient methods of production. As home to the revolution, Britain experienced higher standards of living. Its spiralling cycle of prosperity, demand and production had a profound influence on overseas trade. The company became the single largest player in the British global market. William Henry Pyne notes in his book The Microcosm of London (1808) that:

What country was the home to the Industrial Revolution?
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A:
Britain