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The impressive, costly, and centralised rites to the deities of the Roman state were vastly outnumbered in everyday life by commonplace religious observances pertaining to an individual's domestic and personal deities, the patron divinities of Rome's various neighborhoods and communities, and the often idiosyncratic blends of official, unofficial, local and personal cults that characterised lawful Roman religion. In this spirit, a provincial Roman citizen who made the long journey from Bordeaux to Italy to consult the Sibyl at Tibur did not neglect his devotion to his own goddess from home:

What type of religious practices outnumbered the state observances?
Answer: commonplace
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Martorell's outstanding novel of chivalry Tirant lo Blanc (1490) shows a transition from Medieval to Renaissance values, something that can also be seen in Metge's work. The first book produced with movable type in the Iberian Peninsula was printed in Catalan.

What other writer showed a transition to the Renaissance?
Answer: Metge
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Additionally, genes can have regulatory regions many kilobases upstream or downstream of the open reading frame. These act by binding to transcription factors which then cause the DNA to loop so that the regulatory sequence (and bound transcription factor) become close to the RNA polymerase binding site. For example, enhancers increase transcription by binding an activator protein which then helps to recruit the RNA polymerase to the promoter; conversely silencers bind repressor proteins and make the DNA less available for RNA polymerase.

How do regulatory regions act?
Answer:
by binding to transcription factors