Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: On July 15, 2009 Nucleosys was announced to be disbanding.
Question: What year was the end of Nucleosys?
2009

Context: DNA must replicate (copy) itself so that each resulting cell after mitosis and cell division has the same DNA as the parent cell. All these cells, the parent cell and the two new daughter cells, are genetically identical. DNA replication occurs during the S phase (the Synthesis phase) of the cell cycle, before mitosis and cell division. The base pairing rules are crucial for the process of replication. DNA replication occurs when DNA is copied to form an identical molecule of DNA. The general steps involved in DNA replication are as follows: 1. The DNA helix unwinds like a zipper as the bonds between the base pairs are broken. The enzyme DNA Helicase is involved in breaking these bonds. 2. The two single strands of DNA then each serve as a template for a new stand to be created. Using DNA as a template means that on the new strand, the bases are placed in the correct order because of the base pairing rules. Recall that A and T are complementary bases, as are G and C. As a template strand is read, the new strand is created. If ATGCCA is on the "template strand," then TACGGT will be on the new DNA strand. The enzyme DNA Polymerase reads the template and builds the new strand of DNA. 3. The new set of nucleotides then join together to form a new strand of DNA. The process results in two DNA molecules, each with one old strand and one new strand of DNA. This process is known as semiconservative replication because one strand is conserved (kept the same) in each new DNA molecule ( Figure 1.1). DNA replication occurs when the DNA strands unzip, and the original strands of DNA serve as a template for new nucleotides to join and form a new strand.
Question: what is the first step in dna replication?
the dna helix unwinds like a zipper.

Context: Acute lung injury is a life-threatening condition characterized by surfactant dysfunction and raised secretory phospholipase A2 (sPLA2) activity. Varespladib is a sPLA2 inhibitor shown to be effective in animal models of acute lung injury. We aimed at investigating the effect of co-administration of surfactant and varespladib on sPLA2 activity. Alveolar macrophages were cultured and stimulated with lipopolysaccharide and then treated with either varespladib, surfactant, varespladib followed by surfactant or nothing. sPLA2 activity, free fatty acids, tumour necrosis factor- (TNF-) and protein concentrations were measured in culture supernatants. Treatment with varespladib (p=0.019) and varespladib + surfactant (p=0.013), reduced the enzyme activity by approximately 15% from the basal level measured in the untreated cultures. Surfactant, varespladib and varespladib + surfactant, respectively decreased free fatty acids by -45% (p=0.045), - 62% (p=0.009) and -48% (p=0.015), from the baseline concentration of the untreated cultures. Varespladib and poractant- co-administration reduces sPLA2 activity and free fatty acids release in cultured rat alveolar macrophages, although a clear drug synergy was not evident. Since co-administration may be useful to reduce inflammation and surfactant inactivation in acute lung injury, further in vivo studies are warranted to verify its clinical usefulness.
Question: Which enzyme is inhibited by Varespladib?
secretory phospholipase a2