TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does eHD3-dependent endosome pathway regulate cardiac membrane excitability and physiology?
Answer: These data provide new insight into the critical role of endosome-based pathways in membrane protein targeting and cardiac physiology. EHD3 is a critical component of protein trafficking in heart and is essential for the proper membrane targeting of select cellular proteins that maintain excitability.

SOLUTION: yes

PROBLEM: Question: Is a gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity associated with familial Inappropriate Sinus Tachycardia?
Answer: This is the first report of a gain-of-function HCN4 mutation associated with IST through increased sensitivity to cAMP-dependent activation.

SOLUTION: yes

PROBLEM: Question: Are interferon and Tumor Necrosis Factor Essential Parameters of CD4+ T-Cell Responses for Vaccine Control of Tuberculosis?
Answer: Induction of TH1 cells that coexpress IFN- and TNF is not a requirement for vaccine efficacy against M. tuberculosis, despite these cytokines being essential for control of M. tuberculosis in nonvaccinated animals.

SOLUTION:
no