Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Input: Consider Input: Environmental changes is most responsible for the extinction of most species of plants and animals that have lived on earth.

Output: What process is most responsible for the extinction of most species of plants and animals that have lived on Earth?

Input: Consider Input: Sexually do invertebrates reproduce.

Output: How do invertebrates reproduce?

Input: Consider Input: Memory t cells are long-lived and can even persist for lifetime long.
Output: Memory t cells are long-lived and can even persist for how long?