Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: Ryu (Ha-kyun Shin), a deaf man, works in a factory to support his ailing sister (Ji-Eun Lim) in desperate need of a kidney transplant. Ryu tries to donate one of his kidneys to his sister but is told that his blood type does not match that of his sister and so is not a suitable donor. After being laid off from his job by the factory boss, Ryu contacts a black market organ dealer who agrees to sell him a kidney suitable for his sister in exchange for 10,000,000 Korean won, plus one of Ryu's own kidneys. He takes the severance pay from his factory job and offers the money to the organ dealers, who take the money and one of his kidneys, but then disappear. Three weeks later, Ryu learns from his doctor that a kidney has been found for his sister and that the operation will cost 10,000,000 won, but since the organ dealers stole his money, he will not be able to pay for it.In need of money for the operation and in retaliation for his being fired, Ryu and his girlfriend, Yeong-mi (Doona Bae), a radical anarchist, conspire to kidnap the daughter of the boss who fired him. Instead, he realizes that the kidnapping would immediately put them under police suspicion, and they decide to kidnap Yu-sun (Bo-bae Han), the daughter of the boss's friend, Park Dong-jin (Kang-ho Song), another factory executive. The girl stays with Ryu's sister (thinking that Ryu is merely babysitting for a time), who takes care of her while the distraught Dong-jin arranges to pay her ransom. After Ryu collects the money and returns home, he learns that his sister has discovered his scheme and, unwilling to be involved or burden Ryu further, killed herself. Ryu takes Yu-sun and his sister's body into the countryside to bury her by a riverbed they used to frequent as children. While Ryu mourns, Yu-sun accidentally slips into the river and drowns.Days later, as Dong-jin mourns his daughter and swears revenge at the river bank, Ryu ambushes and murders the organ dealers. Dong-jin, having investigated the identities of the kidnappers, finds Yeong-mi and begins interrogating her. Yeong-mi apologizes for Yu-sun's death but warns him of her membership in a terrorist organization that, knowing Dong-jin's identity, will kill him if she dies. Dong-jin, unfazed by the threats, tortures her to death by electrocuting her. Ryu returns to Yeong-mi's apartment building and discovers the police removing her body on a stretcher. Ryu, consumed with grief, swears vengeance on Dong-jin.Ryu arrives at Dong-jin's residence in an attempt to kill him. He waits for some time, but Dong-Jin does not arrive: he is, in fact, waiting at Ryu's apartment. After Dong-Jin does not arrive, Ryu returns to his apartment. However, Dong-jin had previously set up an electric booby trap on his doorknob, which renders Ryu unconscious. Dong-jin then binds Ryu and returns him to the riverbed where Yu-sun died. After binding Ryu's hands and feet and bringing him chest-high into the water, an emotional Dong-jin acknowledges that although Ryu is a good man, he has no choice; Dong-jin then slashes Ryu's Achilles tendons, resulting in his drowning.Dong-jin drags Ryu back to shore and then drives off to a desolate location to bury the body. Once there, he begins to dig a hole, but soon a group of men arrives. They surround and stab Dong-jin repeatedly, finally attaching a note to his chest identifying themselves as the terrorist group of which Yeong-mi was part. The group leave Dong-jin dying beside his car with the bloody tools and bags he used to chop up, dismember, and package Ryu's body.(From Wikipedia.)
Question: How does Yu-sun die?

Answer: drowns

Question: Context: Ponds are small bodies of fresh water that usually have no outlet; ponds are often are fed by underground springs. Like lakes, ponds are bordered by hills or low rises so the water is blocked from flowing directly downhill. Lakes are larger bodies of water. Lakes are usually fresh water, although the Great Salt Lake in Utah is just one exception. Water usually drains out of a lake through a river or a stream and all lakes lose water to evaporation. Lakes form in a variety of different ways: in depressions carved by glaciers, in calderas (Figure 1.1), and along tectonic faults, to name a few. Subglacial lakes are even found below a frozen ice cap. As a result of geologic history and the arrangement of land masses, most lakes are in the Northern Hemisphere. In fact, more than 60% of all the worlds lakes are in Canada most of these lakes were formed by the glaciers that covered most of Canada in the last Ice Age (Figure 1.2). Lakes are not permanent features of a landscape. Some come and go with the seasons, as water levels rise and fall. Over a longer time, lakes disappear when they fill with sediments, if the springs or streams that fill them diminish, (a) Crater Lake in Oregon is in a volcanic caldera. Lakes can also form in volcanic craters and impact craters. (b) The Great Lakes fill depressions eroded as glaciers scraped rock out from the landscape. (c) Lake Baikal, ice coated in winter in this image, formed as water filled up a tectonic faults. Lakes near Yellowknife were carved by glaciers during the last Ice Age. or if their outlets grow because of erosion. When the climate of an area changes, lakes can either expand or shrink (Figure 1.3). Lakes may disappear if precipitation significantly diminishes. Large lakes have tidal systems and currents, and can even affect weather patterns. The Great Lakes in the United States contain 22% of the worlds fresh surface water (Figure 1.1). The largest them, Lake Superior, has a tide that rises and falls several centimeters each day. The Great Lakes are large enough to alter the weather system in Northeastern United States by the lake effect, which is an increase in snow downwind of the relatively warm lakes. The Great Lakes are home to countless species of fish and wildlife. Many lakes are not natural, but are human-made. People dam a stream in a suitable spot and then let the water back up behind it, creating a lake. These lakes are called "reservoirs." Click image to the left or use the URL below. URL:
Question: which of these is not full of fresh water?

Answer: the great salt lake

Question: Context: To analyze the relationship between the type I interferon (IFN) signature and clinical response to rituximab in rheumatoid arthritis (RA) patients. Twenty RA patients were treated with rituximab (cohort 1). Clinical response was defined as a decrease in the Disease Activity Score evaluated in 28 joints (DAS28) and as a response according to the European League Against Rheumatism (EULAR) criteria at week 12 and week 24. The presence of an IFN signature was analyzed in peripheral blood mononuclear cells by measuring the expression levels of 3 IFN response genes by quantitative polymerase chain reaction analysis. After comparison with the findings in healthy controls, patients were classified as having an IFN high or an IFN low signature. The data were confirmed in a second independent cohort (n = 31). Serum IFN bioactivity was analyzed using a reporter assay. In cohort 1, there was a better clinical response to rituximab in the IFN low signature group. Consistent with these findings, patients with an IFN low signature had a significantly greater reduction in the DAS28 and more often achieved a EULAR response at weeks 12 and 24 as compared with the patients with an IFN high signature in cohort 2 versus cohort 1. The pooled data showed a significantly stronger decrease in the DAS28 in IFN low signature patients at weeks 12 and 24 as compared with the IFN high signature group and a more frequent EULAR response at week 12. Accordingly, serum IFN bioactivity at baseline was inversely associated with the clinical response, although this result did not reach statistical significance. The type I IFN signature negatively predicts the clinical response to rituximab treatment in patients with RA. This finding supports the notion that IFN signaling plays a role in the immunopathology of RA.
Question: Which is the most common gene signature in Rheumatoid Arthritis patients?

Answer:
ifn signature