Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Restless legs syndrome (RLS), recently renamed Willis-Ekbom disease (WED), is a common movement disorder. It is characterised by the need to move mainly the legs due to uncomfortable, sometimes painful sensations in the legs, which have a diurnal variation and a release with movement. Management is complex. First, centres should establish the severity of RLS using a simple 10-item RLS severity rating scale (IRLS). They should also exclude secondary causes, in particular ensuring normal iron levels. Mild cases can be managed by lifestyle changes, but patients with a IRLS score above 15 usually require pharmacological treatment. Dopaminergic therapies remain the mainstay of medical therapies, with recent evidence suggesting opioids may be particularly effective. This article focuses on the different treatment strategies in RLS, their associated complications and ways to manage them.
Willis-Ekbom disease is also known as?

Parkinson's disease is the most common neurodegenerative movement disorder. The motor impairments of Parkinson's disease are caused by the loss of dopaminergic neurons in the substantia nigra and associated with the appearance of fibrillar aggregates of -synuclein (-syn) called Lewy bodies. Approximately 90% of -syn deposited in Lewy bodies is phosphorylated at serine 129 (Ser129). In contrast, only 4% or less of total -syn is phosphorylated at this residue in the normal brain. This suggests that the accumulation of Ser129-phosphorylated -syn leads to the formation of Lewy bodies and dopaminergic neurodegeneration in Parkinson's disease. Our laboratory and others have performed experiments using in vivo models of Parkinson's disease to elucidate the role of increased Ser129 phosphorylation in -syn neurotoxicity. However, there has been a lack of consistency among these models. In this review, we summarize the main findings regarding the relationship between Ser129 phosphorylation and -syn neurotoxicity, and examine the differences among models. We further discuss the role of Ser129 phosphorylation in -syn aggregation and the future directions to test the potential of Ser129 phosphorylation as a therapeutic target for slowing the progression of Parkinson's disease.
Which residue of alpha-synuclein was found to be phosphorylated in Lewy bodies?

Evening Workshops Optional evening workshops will be held at small restaurants or other meeting places near the conference hotel. Meals and other costs are not included but are also optional. Locations will be announced at the conference site. Workshops are very loosely organized and most represent discussions that have been held at Society for Economic Botany (SEB) meetings over a series of years. Workshop 1: Student Network Date: Wednesday evening, Feb. 5th Chairs: Hugo de Boer and Arika Virapongse Sponsor: Society for Economic Botany Description: Student members of the SEB hold a networking mixer each year in order to meet each other and to become familiar with a variety of educational programs and faculty advisors . Faculty members who are part of training programs are encouraged to join the mixer to meet and talk with students. Workshop 2: Botanical Film Making Date: Wednesday evening, Feb. 5th Chair: David Strauch Sponsor: University of Hawaii Description: Digital film making is a particularly useful tool of linking cultural information to recognizable plants. This workshop is aimed towards increasing the quality of material recorded by giving participants greater control over the medium. We will cover technical aspects (e.g. camera settings, audio), technical aspects (framing, lighting, focus), and some ways of presenting the material. Experienced filmmakers are encouraged to attend, and participants are welcome to bring their own camera equipment. Workshop 3: Collections for Botany-- Collections Development and Management Date: Friday evening, Feb. 7th Chair: Jan Salick Sponsor: Society for Economic Botany Description: SEB is a network of researchers who have been developing standards for the development of collections of artifacts, plant samples and related materials. Participants discuss successes, problems, and funding sources for solving management issues.
You are a college student, interested in plants and good at taking TV pictures. Which of the Evening Workshops is most suitable for you?