Teacher:In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Teacher: Now, understand the problem? Solve this instance: The chemokine CXCL10 exerts antiviral effects within the central nervous system (CNS) through the recruitment of virus-specific T cells. However, elevated levels of CXCL10 may induce neuronal apoptosis given its receptor, CXCR3, is expressed by neurons. Using a murine model of West Nile virus (WNV) encephalitis, we determined that WNV-infected neurons express TNF-, which down-regulates neuronal CXCR3 expression via signaling through TNFR1. Downregulation of neuronal CXCR3 decreased CXCL10-mediated calcium transients and delayed Caspase 3 activation. Loss of CXCR3 activation, via CXCR3-deficiency or pretreatment with TNF- prevented neuronal apoptosis during in vitro WNV infection. These results suggest that neuronal TNF- expression during WNV encephalitis may be an adaptive response to diminish CXCL10-induced death.
Student:
TNF--dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis