instruction:
Given an abstract, and a few options, indicate if any of the given options appropriately describe the given abstract. If any of them is a proper keyword, answer 'Yes', otherwise answer 'No'.
question:
Abstract: Early cellular events in the malignant transformation of melanocytes to melanoma are virtually unknown. In vitro investigation of this phenomenon has been hampered by the fastidious nature of the human epidermal melanocyte, which has proven difficult to cultivate. The present study compares responsiveness of cultured human epidermal melanocytes and established melanoma cell lines to serum, cholera toxin, and melanocyte growth factor (MGF), three established melanocyte mitogens. Four of four established human melanoma lines were substantially stimulated by fetal bovine serum, as were newborn foreskin-derived epidermal melanocytes. In contrast, none of the four melanoma lines responded to hypothalamic preparations containing MGF that consistently produced an approximately 30-fold increase in newborn melanocyte cell yield over a 2-week period. Cholera toxin, required for successful establishment of primary melanocyte cultures, had small and variable effects on the melanoma lines, with slight stimulation in one case, moderate inhibition in another, and essentially no effect in two others. These data suggest that transformation of epidermal melanocytes to melanoma often involves at least one phenotypic change resulting in escape from MGF regulation and another associated with insensitivity to cyclic AMP modulation; while at least some of the pathways conferring serum dependence are unaltered. Improved culture systems for the human epidermal melanocyte should facilitate further studies into the mechanism of its malignant conversion and may provide useful insights for the prevention and treatment of human melanoma.
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Animal 2)DNA, Recombinant 3)Mice
answer:
No

question:
Abstract: The relationship between air flow at 38 degrees C and area colour change on a flexible liquid crystal film was found to be virtually linear between the values of 1 and 31 min-1 cm-2. This value of flow per unit area corresponded to values expected at the level of the nostril during quiet breathing. A series of 6 subjects were asked to breathe over a flexible liquid crystal film regularly during the day and the area of colour change produced by flow from each nostril was examined. Four subjects showed a regular change in relative flow through each nostril whilst 2 subjects showed a constant flow through each nostril. This simple and non-invasive technique provides a method of examining the nasal cycle in adults and children in health and disease.
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Adult 2)Female 3)Human 4)Male 5)Nose 6)Respiratory Airflow 7)Support, Non-U.S. Gov't 8)Thermography
answer:
Yes

question:
Abstract: To investigate whether IgG antinuclear antibodies have cross-reactive rheumatoid factor activity, monoclonal IgG antibodies to DNA and Sm from autoimmune MRL-lpr/lpr mice were assayed by ELISA for binding to IgG antigens. Of the nine anti-DNA and anti-Sm monoclonals tested, six showed significant binding to affinity-purified rabbit IgG (RIgG) and human IgG (HIgG). To confirm that cross-reactivities were due to a single antibody, immunoabsorption of a representative polyspecific monoclonal termed C11 (anti-DNA, anti-Sm) on either Sepharose-DNA or Sepharose-RIgG resulted in marked loss of activity to the three antigens DNA, Sm and RIgG compared with immunoabsorption on Sepharose-bovine serum albumin. The monomolecular nature of the cross-reacting antibody was also suggested by inhibition analysis of C11; DNA inhibited C11 binding to RIgG 64%, whereas Sm inhibited binding to RIgG 33%. Aggregated RIgG and HIgG, however, did not inhibit binding of C11 to DNA, Sm, or solid-phase RIgG, probably reflecting the low affinity of this antibody for fluid phase Ig. Together, these findings suggest that antinuclear autoantibodies of the IgG, as well as the IgM, class have polyspecific IgG binding activity and suggest that IgG antinuclear antibodies may emerge from rheumatoid factor responses.
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Acquired Immunodeficiency Syndrome 2)Hepatitis B 3)Hepatitis B Antibodies
answer:
No