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Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled. For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeutic challenges. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections."

What was a once almost controlled disease that is coming back do to resistance?
Answer: tuberculosis
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The oldest known fossil among the Eutheria ("true beasts") is the small shrewlike Juramaia sinensis, or "Jurassic mother from China", dated to 160 million years ago in the Late Jurassic. A later eutherian, Eomaia, dated to 125 million years ago in the Early Cretaceous, possessed some features in common with the marsupials but not with the placentals, evidence that these features were present in the last common ancestor of the two groups but were later lost in the placental lineage. In particular:

How long ago does oldest know fossil date back to?
Answer: 160 million years ago
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Ann Arbor has a typically Midwestern humid continental climate (Koppen Dfa), which is influenced by the Great Lakes. There are four distinct seasons: winters are cold with moderate to heavy snowfall, while summers are very warm and humid, and spring and autumn are short but mild. The area experiences lake effect weather, primarily in the form of increased cloudiness during late fall and early winter. The monthly daily average temperature in July is 72.6 F (22.6 C), while the same figure for January is 24.5 F (4.2 C). Temperatures reach or exceed 90 F (32 C) on 10 days, and drop to or below 0 F (18 C) on 4.6 nights. Precipitation tends to be the heaviest during the summer months, but most frequent during winter. Snowfall, which normally occurs from November to April but occasionally starts in October, averages 58 inches (147 cm) per season. The lowest recorded temperature was 23 F (31 C) on 11 February 1885 and the highest recorded temperature was 105 F (41 C) on 24 July 1934.

How many seasons are experienced in the city of Ann Arbor?
Answer:
four