Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Autosomal-recessive hereditary spastic paraplegias (AR-HSP) consist of a genetically diverse group of neurodegenerative diseases characterised by pyramidal tracts dysfunction. The causative genes for many types of AR-HSP remain elusive. We tried to identify the gene mutation for AR-HSP with cerebellar ataxia and neuropathy. This study included two patients in a Japanese family with their parents who are first cousins. Neurological examination and gene analysis were conducted in the two patients and two normal family members. We undertook genome-wide linkage analysis employing single nucleotide polymorphism arrays using the two patients' DNAs and exome sequencing using one patient's sample. We detected a homozygous missense mutation (c.4189T>G, p.F1397V) in the lysosomal trafficking regulator (LYST) gene, which is described as the causative gene for Chediak-Higashi syndrome (CHS). CHS is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction. This mutation was co-segregated with the disease in the family and was located at well-conserved amino acid. This LYST mutation was not found in 200 Japanese control DNAs. Microscopic observation of peripheral blood in the two patients disclosed large peroxidase-positive granules in both patients' granulocytes, although they had no symptoms of immune deficiency or bleeding tendency. We diagnosed these patients as having adult CHS presenting spastic paraplegia with cerebellar ataxia and neuropathy. The clinical spectrum of CHS is broader than previously recognised. Adult CHS must be considered in the differential diagnosis of AR-HSP.
Question: Which mutated gene causes the ChediakHigashi Syndrome?
lysosomal trafficking regulator gene

Context: From the outside, the skin looks plain and simple, as you can see in Figure 16.5. But at a cellular level, theres nothing plain or simple about it. A single square inch of skin contains about 20 blood vessels, hundreds of sweat glands, and more than a thousand nerve endings. It also contains tens of thousands of pigment-producing cells. Clearly, there is much more to skin than meets the eye! For a dramatic introduction to the skin, watch this video: MEDIA Click image to the left or use the URL below. URL: The skin is only about 2 mm thick, or about as thick as the cover of a book. Although it is very thin, it consists of two distinct layers, called the epidermis and the dermis. You can see both layers and some of their structures in Figure 16.6. Refer to the figure as you read about the epidermis and dermis below. The epidermis is the outer layer of skin. It consists almost entirely of epithelial cells. There are no blood vessels, nerve endings, or glands in this skin layer. Nonetheless, this layer of skin is very active. It is constantly being renewed. How does this happen? 1. The cells at the bottom of the epidermis are always dividing by mitosis to form new cells. 2. The new cells gradually move up through the epidermis toward the surface of the body. As they move, they produce the tough, fibrous protein called keratin. 3. By the time the cells reach the surface, they have filled with keratin and died. On the surface, the dead cells form a protective, waterproof layer. 4. Dead cells are gradually shed from the surface of the epidermis. As they are shed, they are replaced by other dead cells that move up from below. The epidermis also contains cells called melanocytes. You can see a melanocyte in Figure 16.7. Melanocytes produce melanin. Melanin is a brown pigment that gives skin much of its color. Everyones skin has about the same number of melanocytes per square inch. However, the melanocytes of people with darker skin produce more melanin. The amount of melanin that is produced depends partly on your genes and partly on how much ultraviolet light strikes your skin. The more light you get, the more melanin your melanocytes produce. This explains why skin tans when its exposed to sunlight. The dermis is the inner layer of skin. It is made of tough connective tissue. The dermis is attached to the epidermis by fibers made of the protein collagen. The dermis is where most skin structures are located. Look again at Figure pain, pressure, and temperature. If you cut your skin and it bleeds, the cut has penetrated the dermis and damaged a blood vessel. The cut probably hurts as well because of the nerve endings in this skin layer. The dermis also contains hair follicles and two types of glands. You can see some of these structures in Figure 16.8. Hair follicles are structures where hairs originate. Each hair grows out of a follicle, passes up through the epidermis, and extends above the skin surface. Sebaceous glands are commonly called oil glands. They produce an oily substance called sebum. Sebum is secreted into hair follicles. Then it makes its way along the hair shaft to the surface of the skin. Sebum waterproofs the hair and skin and helps prevent them from drying out. Sweat glands produce the salty fluid known as sweat. Sweat contains excess water, salts, and other waste products. Each sweat gland has a duct that passes through the epidermis. Sweat travels from the gland through the duct and out through a pore on the surface of the skin. You couldnt survive without your skin. It has many important functions. In several ways, it helps maintain homeostasis. The main function of the skin is controlling what enters and leaves the body. It prevents the loss of too much water from the body. It also prevents bacteria and other microorganisms from entering the body. Melanin in the epidermis absorbs ultraviolet light. This prevents the light from reaching and damaging the dermis. The skin helps maintain a constant body temperature. It
Question: __oily substance secreted by glands in the skin
sebum

Context: Coming off their road win over the Packers, the Falcons went home for a Week 6 duel with the Chicago Bears. In the first quarter, Atlanta took flight as kicker Jason Elam got a 29-yard and a 48-yard field goal. In the second quarter, the Falcons increased their lead as Elam kicked a 32-yard field goal. The Bears would respond with kicker Robbie Gould getting a 36-yard field goal.Entering Sunday game with the Bears, the Falcons led the NFL in first quarter scoring with 48 points. After posting two field goals for a 6-0 lead following the first 15 minutes of play against Chicago, Atlanta has now outscored its opponent in the first quarter by a 54-14 margin. A chance at a touchdown came with 9:16 remaining in the first half after a curious turn of events near the goal line. A third-down run by Jerious Norwood came up short and ended with a fumble. Bears defensive tackle Tommie Harris recovered but lost the ball before he was touched down. Jason Snelling recovered the ball for the Falcons, who got a fresh set of downs. Following the first half of play, the Falcons defense held the Bears to 20 first half rushing yards. The 20 yards are the fewest given up in the first half of a game by Atlanta's defense since October 1, 2006, against Arizona (two yards). In the third quarter, the Falcons continued to add onto their lead as Elam got a 41-yard field goal, yet Chicago answered with RB Matt Forte getting a 3-yard TD run. In the fourth quarter, Atlanta replied with rookie quarterback Matt Ryan completing a 3-yard TD pass to WR Roddy White. Defensive end Jamaal Anderson paced a defense that fed off the crowd's energy. He finished with four tackles (two for loss) and the first sack of his two-year career. Anderson also had two pass deflections on the Bears' first drive of the second quarter.The Falcons offense started the second half with a no-huddle offense and added another Elam field goal to take a 12-3 lead. Chicago stuck with the running game and added a touchdown from Forte with 2:24 remaining in the third quarter. Chicago drove within inches of the end zone, but Matt Forte was stuffed on fourth down as he attempted to leap across the line. Michael Boley came in low to trip up the runner, then Lawyer Milloy and Keith Brooking finished him off.The Bears took the lead with Gould getting a 32-yard field goal, along with quarterback Kyle Orton completing a 17-yard TD pass to WR Rashied Davis. Fortunately, the Falcons got the last laugh as Elam nailed the game-winning 48-yard field goal.The 16-year veteran's celebration was interrupted by a swarm of teammates near midfield. It was his fifth successful kick of the day but just moments before he missed a kick that could have iced the game. Chicago came off the miscue with a 77-yard touchdown drive to take a 20-19 lead with 11 seconds to play. But a 9-yard return off a short kickoff by Harry Douglas and a 26-yard strike from rookie quarterback Matt Ryan to Michael Jenkins set Elam up for the game-winner with 1 second left. "I'm really happy that one went through", Elam said. "Our guys have been fighting so hard for so long. I hate to even mention what happened last year but to hear some of the stories I know the guys are really hungry to get some wins on the board and show our fans what we're all about." With time to throw Ryan thrived. The rookie found five different receivers and performed regular Houdini-like acts to find open players down the field for third-down conversions. Fellow rookie Douglas caught five passes for 96 yards including a 47-yard strike on third down that set up a 3-yard scoring toss to White with 13:25 remaining.Ryan opened the game 8-of-8 for 107 yards and captained nearly identical scoring drives in the first quarter, leading the team on 48- and 49-yard marches that ended with field goals."I think everybody is excited with the win", Ryan said. "I thought we played a very good Chicago Bears team today
Question: Which distance did Elam kick two field goals from?
48-yard