Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Example Input: Context: Aleksandr Andreyevich Samokhvalov (1894--1974) was a Russian painter and graphic artist.
Question: What was the date of birth of Aleksandr Andreyevich Samokhvalov?
Example Output: 1894

Example Input: Context: Biologists agree that the ancestor of mitochondria was an alpha-proteobacterium. But there is no consensus as to what constitutes an alpha-proteobacterial gene. Is it a gene found in all or several alpha-proteobacteria, or in only one? Here, we examine the proportion of alpha-proteobacterial genes in alpha-proteobacterial genomes by means of sequence comparisons. We find that each alpha-proteobacterium harbours a particular collection of genes and that, depending upon the lineage examined, between 97 and 33% are alpha-proteobacterial by the nearest-neighbour criterion. Our findings bear upon attempts to reconstruct the mitochondrial ancestor and upon inferences concerning the collection of genes that the mitochondrial ancestor possessed at the time that it became an endosymbiont.
Question: Which species of bacteria did the mitochondria originate from?
Example Output: biologists agree that the ancestor of mitochondria was an alpha-proteobacterium.

Example Input: Context: Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. -Synuclein (-syn) is a soluble protein present in the pre-synaptic terminal of neurons. Evidence suggests that -syn has a fundamental role in PD pathogenesis, given that it is an important component of Lewy bodies localized in the dopaminergic neurons of PD patients. In the present study, we investigated the influence of wild type (WT) and A30P -syn overexpression on neuroblastoma SH-SY5Y toxicity induced by the conditioned medium (CM) from primary cultures of glia challenged with lipopolysaccharide (LPS) from Escherichia coli. We observed that SH-SY5Y cells transduced with -syn (WT or A30P) and treated with CM from LPS-activated glia cells show evidence of cell death, which is not reverted by NF-B inhibition by sodium salicylate or by blockage of P50 (NF-B subunit). Furthermore, the expression of A30P -syn in neuroblastoma SH-SY5Y decreases the cell death triggered by the CM of activated glia versus WT -syn or control group. This effect of A30P -syn may be due to the low MAPK42/44 phosphorylation. This finding is substantiated by MEK1 inhibition by PD98059, decreasing LDH release by CM in SH-SY5Y cells. Our results suggest that SH-SY5Y cells transduced with -syn (WT or A30P) and treated with CM from LPS-activated glia cells show cell death, which is not reverted by NF-B blockage. Additionally, the expression of A30P -syn on neuroblastoma SH-SY5Y leads to decreased cell death triggered by the CM of activated glia, when compared to WT -syn or control group. The mechanism underlying this process remains to be completely elucidated, but the present data suggest that MAPK42/44 phosphorylation plays an important role in this process. CRD42015020829.
Question: Which is the primary protein component of Lewy bodies?
Example Output:
syn