Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Input: Consider Input: Paragraph: "Ohio Sen. Rob Portman has been busy in Washington touting the Comprehensive Addiction Recovery Act in response to a shocking number of heroin overdoses in Ohio. The bill just passed in the Senate, 94-1. (Nebraska Sen. Ben Sasse was the sole ""nay,"" saying he believes that fighting addiction is a local issue.) Ohio ranks high on the list of states reeling from the national epidemic. In Montgomery County, which encompasses Dayton, Ohio, heroin-related deaths increased 225 percent between 2011 and 2015. Back in the 1970s, the heroin on U.S. streets was the ""black tar"" variety, and much of it came from southeast Asia. In 2010, 80 percent of the heroin in the world came from poppy fields in Afghanistan, according to the Office of National Drug Control Policy. So when Portman said that most of the heroin in America comes from Mexico's border, we were skeptical. Portman, it turns out, has done his homework. The Drug Enforcement Administration's National Drug Threat Assessment of 2015 says that Mexico is the primary supplier of heroin to the United States. ""Southeast Asia was once the dominant supplier of heroin in the United States, but Southeast Asian heroin is now rarely detected in U.S. markets,"" the report state. ""Mexico and, to a lesser extent, Colombia dominate the U.S. heroin market, because of their proximity, established transportation and distribution infrastructure, and ability to satisfy U.S. heroin demand."" The report also says that Mexican ""transnational criminal organizations,"" (the DEA's term for drug-dealing gangs) ""pose the greatest criminal drug threat to the United States; no other group is currently positioned to challenge them."" The National Drug Threat report notes that Colombian gangs were traditionally the suppliers of wholesale cocaine and heroin to Mexican and Dominican groups. But cartels in Mexico are ramping up their roles on the supply side -- opium production in Mexico increased by 50 percent in 2014. Mexican labs also produce fentanyl, a synthetic painkiller that is 80 to 100 times stronger than morphine. Fentanyl is sometimes mixed with heroin or substituted for heroin, and the DEA reports more than 700 overdoses attributed to fentanyl between late 2013 and early 2015. Drugs get past the U.S. borders mostly ""by land, not by sea,"" said Homeland Security Secretary Jeh Johnson, in the same March 8 hearing with Portman. And a 2015 Washington Post series on the surge of heroin puts the border detection rate at a scant 1.5 percent. Smugglers' creativity defies gravity: One successful bust came when agents caught two men flying a drone carrying 28 pounds of heroin from Mexico to California. Our ruling Portman said that heroin is coming to the United States primarily from Mexico. He hasn't been studying drug facts for nothing." Claim: We understand that this heroin is primarily coming from Mexico, over the border.

Output: Portman said that heroin is coming to the United States primarily from Mexico. He hasn't been studying drug facts for nothing.

Input: Consider Input: Paragraph: Although Pfizer continues to test the drug, called dacomitinib, in another Phase III study, hopes for its success have now largely faded, according to ISI Group analyst Mark Schoenebaum. "We believe consensus expectations (for the drug) will be close to zero given today's readout" of unsuccessful trial results, Schoenebaum said in a research note. In one of the failed trials, called ARCHER 1009, patients given Pfizer's once-daily pill did not show improved survival without the cancer worsening, compared with Roche Holding AG's widely used Tarceva (erlotinib). Tarceva is the current standard of care in patients with mutated forms of a protein called Epidermal Growth Factor Receptor (EGFR). The protein plays a role in normal regulation of cell growth, but when mutated is believed to cause cells to proliferate and thereby help spur various types of cancer. Dacomitinib is designed to block several types of Epidermal Growth Factor receptors, while Tarceva and similar treatments for lung cancer target only one type of receptor. Cowen and Co had forecast annual sales of $500 million by 2020 for dacomitinib, if it were approved for lung cancer. That would make it a moderate-sized product for Pfizer, the largest U.S. drugmaker, which has annual revenue of $50 billion. Schoenebaum said there has been little investor interest in the drug and that Wall Street had expected it to generate annual sales of only $300 million by 2018. The second failed trial, named BR.26, involved patients that previously had failed to benefit from chemotherapy as well as from treatment with an EGFR inhibitor. Overall survival of patients taking the Pfizer drug was not prolonged in the study, compared with patients given a placebo. Pfizer said adverse events seen with dacomitinib were consistent with those seen in smaller earlier studies. In the meantime, Pfizer said dacomitinib is also being tested in a third late-stage trial, called ARCHER 1050, among patients with advanced non-small cell lung cancer who have not received prior treatment. The study will compare dacomitinib with Iressa (gefitinib), an EGFR inhibitor sold by AstraZeneca Plc. Results from that study are expected in 2015. Pfizer shares were little changed in morning trading on the New York Stock Exchange. Claim: Pfizer lung cancer drug fails in two large studies.

Output: Pfizer Inc on Monday said one of its experimental drugs had failed to meet its goals in two late-stage studies among patients who had received prior treatment for advanced non-small cell lung cancer, the most common form of the disease.

Input: Consider Input: Paragraph: But experts caution it is premature to say whether the unprecedented double-whammy of storms to hit the southern African nation is a consequence of climate change, and whether these cyclones will become more common. Cyclone Idai, which swamped large parts of central Mozambique last month, killed over 600 people and displaced thousands. Cyclone Kenneth made landfall Thursday evening in the north of the country where no such storm has been recorded since satellite observations began in the 1970s. "There is no record of two storms of such intensity striking Mozambique in the same season," said Clare Nullis, a spokeswoman for the World Meteorological Organization. "It is difficult to pronounce on one event like Idai, or even two like Idai and Kenneth. The statistical size of the sample is just too small," she said. "But one thing is sure: The vulnerability of coastal areas will become worse with the sea-level rise induced by global warming." Inland areas, too, are at risk because storms are getting wetter. Kenneth, which has weakened to a tropical depression, is expected to bring heavy rainfall to already saturated soil and dams at the end of the rainy season. "While attention is often given to wind speed, we know from experience that it is rainfall and subsequent flooding and landslides that can be even more dangerous from a humanitarian perspective," said Antonio Carabante, an emergency relief delegate with the International Federation of Red Cross and Red Crescent Societies. "This was certainly the case for Cyclone Idai," Carabante said, adding that many affected areas are prone to flooding and landslides even with normal levels of rainfall. "And this is far from a normal situation." Such conditions can be particularly devastating for developing countries like Mozambique and neighboring Malawi and Zimbabwe, all hit by Cyclone Idai, where food stores can be quickly depleted in a disaster and the health care system struggles to cope with a sudden disease outbreak like cholera. "Cyclone Kenneth may require a major new humanitarian operation at the same time that the ongoing Cyclone Idai response targeting 3 million people in three countries remains critically underfunded," said the U.N.'s emergency relief coordinator, Mark Lowcock, who described the situation as a "climate-related disaster." Abubakr Salih Babiker, a meteorologist at the Nairobi-based Intergovernmental Authority on Development, said there are indications that tropical cyclones are becoming more common off East Africa as rising sea surface temperatures are a key ingredient for cyclones to form. "There's a pattern here," he said, citing recent violent storms from Somalia in the Horn of Africa down to Mozambique. "What used to be rare is not rare anymore." And just as warmer seas are helping spark cyclones, hotter air is feeding the resulting rainfall, Salih Babiker said. "If the air is warmer, it has more ability to hold moisture." The World Meteorological Organization said this year's cyclone season in the southwest Indian Ocean has been exceptionally intense, with 15 storms including nine intense cyclones. It is now tied with the record season of 1993-1994. Nullis said the agency is sending an expert delegation to Mozambique to discuss with the government how to improve its resilience to extreme weather. Long and narrow with a 2,400-kilometer (1,500-mile) Indian Ocean coastline, the country is one of the world's most vulnerable to global warming. Claim: Ocean changes affected deadly duo of Mozambique cyclones.
Output: Warming waters and rising sea levels are affecting Indian Ocean cyclones such as those that have wrought havoc in Mozambique in recent weeks, making them potentially more deadly.