Given the task definition and input, reply with output. Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.

The optimal repair of DNA lesions is fundamental for physiological processes. We asked whether the recruitment of HP1, 53BP1 and BMI1 proteins to ultraviolet (UVA)-induced DNA lesions requires functional A-type lamins.', 'We found that UVA irradiation of nuclear lamina abolished the fluorescence of mCherry-tagged A-type lamins and destroyed the nuclear lamina as also observed by electron microscopy studies. Similarly, an absence of endogenous A- and B-type lamins was found in irradiated regions by UVA. However, irradiation did not affect the recruitment of HP1, 53BP1 and BMI1 to DNA lesions. The UVA-induced shrinkage of the nuclear lamina, which anchors chromatin, explains why UVA-micro-irradiated chromatin is relaxed. Conversely, additional experiments with -irradiation showed that the nuclear lamina remained intact and the genome-wide level of HP1 was stable. Fluorescence intensity of HP1 and BMI1 in UVA-induced DNA lesions and level of HP1 after -irradiation were unaffected by deficiency in A-type lamins, whereas those parameters of 53BP1 were changed.
0