Q: I have a new situation: Uncle Tom and uncle Sam both have high cholesterol. Uncle Tom is on statin drugs and uncle Sam is not. But I can use this background: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. What is an answer for this question: Which uncle takes an inhibitor of HMG-CoA reductase?
A: Tom

Q: I have a new situation: David works for a large pharmaceutical company as a research scientist. He has devised a procedure which can detect lactose intolerance in patients easily. To test his procedure he picked up four subjects form a large pool of sample. The four subjects are subject A, subject B, subject C, and subject D. Subject A has primary lactose intolerance; subject B has secondary lactose intolerance; subject C has developmental lactose intolerance; and subject D has congenital lactose intolerance. But I can use this background: Lactose intolerance is due to the lack of enzyme lactase in the small intestines to break lactose down into glucose and galactose.[3] There are four types: primary, secondary, developmental, and congenital.[1] Primary lactose intolerance occurs as the amount of lactase declines as people age.[1] Secondary lactose intolerance is due to injury to the small intestine such as from infection, celiac disease, inflammatory bowel disease, or other diseases.[1][4] Developmental lactose intolerance may occur in premature babies and usually improves over a short period of time.[1] Congenital lactose intolerance is an extremely rare genetic disorder in which little or no lactase is made from birth.[1] What is an answer for this question: Which subject has lactose intolerance due to genetic disorder, subject B or subject D?
A: subject D

Q: I have a new situation: Two old friends Mary and Ann lived thousands of miles away. Mary lived on the Big Island of Hawaii, while Ann lived in Boston. Mary visited Boston, while Ann has never been to Hawaii. But I can use this background: The Hawaiian Islands ( Figure above ) are in the central Pacific Ocean. The islands are volcanoes that increase in age from southeast to northwest. The youngest island is the Big Island of Hawaii at the southeast end of the chain. The volcanoes get older through Maui, Kahoolawe, Lanai, Molokai, Oahu, Kauai, and Niihau Islands through the northwest. The Kilauea volcano on Hawaii has been erupting almost continuously since 1983. There are also eruptions at an underwater volcano called Loihi seamount. Loihi is the youngest volcano. Hawaii is a fantastic place to see volcanic eruptions and features. What is an answer for this question: Which friend lived near Kauai Island?
A: Mary

Q: I have a new situation: Bob is a biologist. Today, he has four samples of organisms to test, sample A, sample B, sample C, and sample D. He induced higher respiration rate in sample A. Then he induced no respiration rate in sample B. Next, he classified sample C as heterotrophic and sample D as autotrophic. But I can use this background: There must be more to this story than just gas exchange with the environment. To begin to appreciate the role of oxygen inside your body, think about when your breathing rate increases: climbing a steep slope, running a race, or skating a shift in a hockey game. Respiration rate correlates with energy use, and that correlation reflects the link between oxygen and energy metabolism. For this reason, the chemical process inside your cells that consume oxygen to produce usable energy is known as cellular respiration . During this process, energy is converted from glucose , in the presence of oxygen, into numerous ATP molecules. The glucose, of course, comes from the food you eat. In biological terms, you do not eat because you are hungry, you eat to get energy. Other heterotrophic organisms also acquire glucose from other organisms, whereas autotrophic organisms make their own glucose, mostly through photosynthesis. What is an answer for this question: In which organism cellular respiration would occur, sample A or sample B?
A:
sample A