TASK DEFINITION: Given an abstract, and a few options, indicate if any of the given options appropriately describe the given abstract. If any of them is a proper keyword, answer 'Yes', otherwise answer 'No'.
PROBLEM: Abstract: We examined the activity of defensins, cysteine-rich cationic peptides that are abundant in the cytoplasmic granules of human and rabbit granulocytes, against various tumor targets. The three human defensins, HNP-1, HNP-2, and HNP-3, lysed human and murine targets in chromium release and dye exclusion assays. Defensin-mediated tumor cell lysis was concentration-dependent, inhibited by serum, and dependent on temperature-sensitive events. Lysis was first detected by three hours of incubation and it reached a plateau between eight and 14 hours. In vitro exposure of murine teratocarcinoma cells to HNP 1-3 abrogated their oncogenicity in vivo. Nonmalignant target cells were also susceptible to defensin-mediated lysis. Four rabbit granulocyte defensins exerted marked (NP-1, NP-2) or moderate (NP-3a, NP-3b) cytotoxic activity, whereas defensin NP-5 was not cytotoxic. When tumor cells were incubated with human defensins in combination with hydrogen peroxide, synergistic cytotoxicity was detected. As defensins are released from granulocytes by various stimuli, their release could contribute to extracellular cytotoxicity which is independent of reactive oxygen intermediates.
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Animal 2)Blood Proteins 3)Cytotoxicity, Immunologic 4)Drug Synergism 5)Human 6)Hydrogen Peroxide 7)Kinetics 8)Mice 9)Neoplasms, Experimental 10)Neutrophils 11)Rabbits 12)Species Specificity 13)Support, U.S. Gov't, Non-P.H.S. 14)Support, U.S. Gov't, P.H.S..

SOLUTION: Yes

PROBLEM: Abstract: The urine urea nitrogen/urine creatinine excretion ratio (UUN/UCr) of a "spot" urine specimen obtained approximately 5 hours after the last meal of the day can be used to accurately calculate the urinary urea excretion for the previous 24-hour period. Because UUN excretion is largely determined by dietary intake of protein nitrogen, this method can be used to estimate dietary protein intake for the previous 24-hour period. Strategies for using this simple method for inexpensively and continuously monitoring dietary protein intake are discussed.
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Animal 2)Antibodies 3)Embryo, Non-Mammalian

SOLUTION: No

PROBLEM: Abstract: The Coronary Drug Project was conducted between 1966 and 1975 to assess the long-term efficacy and safety of five lipid-influencing drugs in 8,341 men aged 30 to 64 years with electrocardiogram-documented previous myocardial infarction. The two estrogen regimens and dextrothyroxine were discontinued early because of adverse effects. No evidence of efficacy was found for the clofibrate treatment. Niacin treatment showed modest benefit in decreasing definite nonfatal recurrent myocardial infarction but did not decrease total mortality. With a mean follow-up of 15 years, nearly 9 years after termination of the trial, mortality from all causes in each of the drug groups, except for niacin, was similar to that in the placebo group. Mortality in the niacin group was 11% lower than in the placebo group (52.0 versus 58.2%; p = 0.0004). This late benefit of niacin, occurring after discontinuation of the drug, may be a result of a translation into a mortality benefit over subsequent years of the early favorable effect of niacin in decreasing nonfatal reinfarction or a result of the cholesterol-lowering effect of niacin, or both.
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Biopsy 2)Human 3)Myocarditis

SOLUTION:
No