Input: Read this: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.
Question: What does NMEs stand for?

Output: New Molecular Entities

Input: Read this: Originally, international law was unaccepting of treaty reservations, rejecting them unless all parties to the treaty accepted the same reservations. However, in the interest of encouraging the largest number of states to join treaties, a more permissive rule regarding reservations has emerged. While some treaties still expressly forbid any reservations, they are now generally permitted to the extent that they are not inconsistent with the goals and purposes of the treaty.
Question: A more permissive rule regarding what emerged to encourage the largest number of states to join treaties?

Output: reservations

Input: Read this: Fiame Mata'afa Faumuina Mulinu'u II, one of the four highest-ranking paramount chiefs in the country, became Samoa's first Prime Minister. Two other paramount chiefs at the time of independence were appointed joint heads of state for life. Tupua Tamasese Mea'ole died in 1963, leaving Malietoa Tanumafili II sole head of state until his death on 11 May 2007, upon which Samoa changed from a constitutional monarchy to a parliamentary republic de facto. The next Head of State, Tuiatua Tupua Tamasese Efi, was elected by the legislature on 17 June 2007 for a fixed five-year term, and was re-elected unopposed in July 2012.
Question: What year did the first of the two heads of state die?

Output: 1963

Input: Read this: Manhattan Island is linked to New York City's outer boroughs and New Jersey by several tunnels as well. The Lincoln Tunnel, which carries 120,000 vehicles a day under the Hudson River between New Jersey and Midtown Manhattan, is the busiest vehicular tunnel in the world. The tunnel was built instead of a bridge to allow unfettered passage of large passenger and cargo ships that sailed through New York Harbor and up the Hudson River to Manhattan's piers. The Holland Tunnel, connecting Lower Manhattan to Jersey City, New Jersey, was the world's first mechanically ventilated vehicular tunnel when it opened in 1927. The Queens-Midtown Tunnel, built to relieve congestion on the bridges connecting Manhattan with Queens and Brooklyn, was the largest non-federal project in its time when it was completed in 1940. President Franklin D. Roosevelt was the first person to drive through it. The Hugh L. Carey Tunnel runs underneath Battery Park and connects the Financial District at the southern tip of Manhattan to Red Hook in Brooklyn.
Question: What borough is connected to New Jersey via the Lincoln Tunnel?

Output:
Manhattan