Instructions: In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.
Input: Context: Long-term prognosis of hepatocellular carcinoma (HCC) patients is challenging, and novel biomarkers are needed to predict patient risk and serve as potential therapeutic target.', 'We found -glucosidase 1 is significantly overexpressed and activated in primary HCC tissue and multiple HCC cell lines. -Glucosidase 1 expression is associated with predicting prognosis of HCC patients under chemotherapy. Silencing -glucosidase 1 inhibits growth and survival of HCC cells, with preferential inhibitory effects on high -glucosidase 1-expressing cells. Combination of chemo drug with -glucosidase 1 inhibitor sensitized HCC cells to chemotherapy.\Question: Is identification of -glucosidase 1 as a biomarker and its high expression in hepatocellular carcinoma associated with resistance to chemotherapy drugs?
Output:
Our data support -glucosidase 1 as a HCC biomarker due to its prognosis significance.