Detailed Instructions: Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Q: Context: Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD biomarkers and cognitive tests.', "Elderly controls enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n=158) underwent florbetapir-PET scans, psychometric testing, neuroimaging with MRI and PET, and APOE genetic testing. Elderly controls the Parkinson's progression markers initiative (PPMI, n=58) had WMH volume, cerebrospinal fluid (CSF) A1-42, and APOE status measured.", 'In the ADNI cohort, only WMH volume and APOE 4 status were associated with cerebral A (standardized =0.44 and 1.25, P=.03 and .002). The association between WMH volume and APOE 4 status with cerebral A (standardized =1.12 and 0.26, P=.048 and .045) was confirmed in the PPMI cohort.
Answer: WMH volume is more highly associated with preclinical AD than other AD biomarkers.
A:
Are white matter hyperintensities more highly associated with preclinical Alzheimer 's disease than imaging and cognitive markers of neurodegeneration?