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Before handling or cutting through your MDF piece, make sure to put on a pair of heavy-duty working gloves and a durable, long-sleeved shirt. This will give you a small layer of defense against rough MDF edges and your saw blade. To avoid getting caught in the saw blade, do not wear clothing with loose sleeves. When cut, MDF releases a massive amount of dust particles into the air. To make sure this dust doesn't get into your eyes or throat, wear a high quality dust mask and a pair of clear safety goggles while working. MDF dust particles are not inherently dangerous, but the sheer amount of them may lead to unwanted irritation. Since MDF releases so much dust, try to cut your wood outside or in an open room like a garage. If you don't have a clear space to work in, open any windows or doors near the cutting area so the dust has a way to escape. If you'd like, place a fan in the room to help blow the dust outside. Cover objects around your working area in thin plastic sheets to keep them from getting dirty.
Put on thick working gloves and a long-sleeved shirt. Wear a dust mask and safety goggles. Make your cuts in a large, clear area.