Given the task definition and input, reply with output. In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Paragraph: The radiolabeled isatin sulfonamide caspase-3 inhibitor, [ 18 F]2 (WC-II-89), is a potential PET radiotracer for noninvasive imaging of apoptosis. The radiolabeling mechanism was studied by 13 C NMR, ESI/MS, and computational calculations. It was found that the high electrophilicity of the C3 carbonyl group in the isatin ring, which served as a trap for [ 18 F]fluoride, was responsible for the failure of the radiolabeling via nucleophilic substitution of the mesylate group in 7a by [ 18 F]fluoride. Once treated with a strong base, 7a opened the isatin ring completely to form an isatinate intermediate 16, which lost the ability to trap [ 18 F]fluoride, thereby allowing the displacement of the mesylate group to afford the 18 F-labeled isatinate 17. [ 18 F]17 can be converted to isatin [ 18 F]2 efficiently under acidic conditions. The ring-opening and re-closure of the isatin ring under basic and acidic conditions were confirmed by reversed phase HPLC analysis, ESI/MS and 13 C NMR studies. Computational studies of model compounds also support the above proposed mechanism. Similarly, the ring-opening and re-closure method was used successfully in the synthesis of the 11 C labeled isatin sulfonamide analogue [ 11 C]4 (WC-98). A microPET imaging study using [ 11 C]4 in the Fas liver apoptosis model demonstrated retained activity in the target organ (liver) of the treated mice. Increased caspase-3 activation in the liver was verified by the fluorometric caspase-3 enzyme assay. Therefore, this study provides a useful method for radiosynthesis of isatin derivative radiotracers for PET and SPECT studies, and [ 11 C]4 is a potential PET radiotracer for noninvasive imaging of apoptosis.
Title: [ 18 F]-and [ 11 C]-Labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging of apoptosis in Fas-treated mice NIH Public Access Author Manuscript
True