Given the task definition and input, reply with output. In this task, we ask you to rewrite a sentence in simple English without changing its general meaning. Essentially, you want to make the sentence easier to read by using simpler words, utilizing more straightforward sentence structures, and omitting non-essential information etc.

Vacuoles also play a major role in autophagy , maintaining a balance between biogenesis ( production ) and degradation ( or turnover ) , of many substances and cell structures in certain organisms .
Vacuoles are also important in autophagy , keeping a balance between making and getting rid of many things in cells and organisms .