Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

[Q]: Abstract: To assess the usefulness of continuous wave Doppler echocardiography in the evaluation of aortic insufficiency, the aortic regurgitant flow velocity pattern obtained with continuous wave Doppler examination was compared with the results of aortography and conventional pulsed Doppler techniques in 25 individuals with aortic insufficiency. The diastolic deceleration slope as measured from the continuous wave tracing was significantly different among subgroups of patients with mild (1.6 +/- 0.5 m/s2), moderate (2.7 +/- 0.5 m/s2) and severe (4.7 +/- 1.5 m/s2) aortic insufficiency as determined from aortography. Deceleration slopes greater than 2 m/s2 separated individuals with moderate and severe insufficiency from those with mild insufficiency. Similar findings were seen when comparing the pressure half-time method of diastolic velocity decay with the more severe grades of aortic insufficiency exhibiting the shortest pressure half-times. There was also a high correlation (r = 0.85) between the deceleration slope measured by continuous wave Doppler recordings and the grade of insufficiency as assessed by pulsed Doppler echocardiography. End-diastolic velocities correlated poorly (r = 0.28) with catheter-measured end-diastolic pressure difference between the aorta and the left ventricle. These findings demonstrate that the aortic regurgitant flow pattern by continuous wave Doppler echocardiography may be useful in quantitating the degree of aortic insufficiency by assessing the rate with which aortic and left ventricular pressures equilibrate during diastole.
Which is the apt title for the abstract? option1: Quantitative evaluation of aortic insufficiency by continuous wave Doppler echocardiography. option2: Familial dependence of the resting metabolic rate [letter]
[A]: Quantitative evaluation of aortic insufficiency by continuous wave Doppler echocardiography.

[Q]: Abstract: Erythema nodosum leprosum (ENL) is a reactional state of lepromatous leprosy in which the loss of suppressor cell function, decrease in suppressor cell numbers, and increase of interleukin 2 production are observed. We reasoned that cyclosporine A (CsA), by opposing these immune responses, could suppress the ENL reaction and restore patients to the quiescent lepromatous state. We tested this hypothesis in vitro by measuring the effect of CsA on M. leprae-triggered suppressor cells. In 24 of 25 patients with ENL, suppressor cell activity was restored by CsA. The target of CsA appeared to be macrophages. These findings are significant in that they provide the first evidence for the potential efficacy of CsA in the treatment of ENL. Preliminary clinical trials indicate a beneficial therapeutic effect associated with increased T suppressor cells in lesions.
Which is the apt title for the abstract? option1: Effect of cyclosporine A in erythema nodosum leprosum. option2: Hepatitis B: cheap vaccine for wide use? [news]
[A]: Effect of cyclosporine A in erythema nodosum leprosum.

[Q]: Abstract: The influence of serotonin (5-hydroxytryptamine) on human detrusor and on pig detrusor, trigone, bladder neck and urethral smooth muscle was explored in a series of in vitro experiments. Serotonin evoked a dose-dependent and reversible contraction of the detrusor. The reverse response was triggered in trigone, bladder neck and urethral smooth muscle--a dose-dependent and reversible relaxation. The maximum amplitude of this relaxation was 85 +/- 15% of the relaxation produced by electrical nerve stimulation. The effect of serotonin was unaltered by blockade of ganglia, alpha- and beta-adrenergic receptors, cholinergic receptors and prostaglandin synthesis. The serotonin antagonists ketanserin, methysergide and cyproheptadine partly inhibited the effect of serotonin. The antagonism differed in potency on strips of different origin. The antagonists were ineffective or minimally effective in blocking responses to nerve stimulation. The effect of serotonin was probably mediated by specific serotonin receptors different from the serotonin-S2-receptors predominating in vascular smooth muscle. Serotonin is a potential neurotransmitter in lower urinary tract smooth muscle, but its importance in micturition physiology and pathophysiology is unknown.
Which is the apt title for the abstract? option1: Influence of serotonin on lower urinary tract smooth muscle in vitro. option2: Intestinal lymphangiectasia and bilateral pleural effusions: effect of dietary therapy and surgical intervention on immunologic and pulmonary parameters.
[A]:
Influence of serotonin on lower urinary tract smooth muscle in vitro.