Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Mr. Flip is a 1909 American silent comedy film made by Essanay Studios, directed by Gilbert M. 'Broncho Billy' Anderson and starring Ben Turpin.

Output: What production company was involved in Mr. Flip?

Input: Consider Input: Sidi Barrani (Egyptian Arabic: pronounced (sidi bni)) is a town in Egypt, near the Mediterranean Sea, about 95 km (59 mi) east of the border with Libya, and around 240 km (150 mi) from Tobruk, Libya.

Output: By which body of water is Sidi Barrani located?

Input: Consider Input: The interpretation of non-coding variants still constitutes a major challenge in the application of whole-genome sequencing in Mendelian disease, especially for single-nucleotide and other small non-coding variants. Here we present Genomiser, an analysis framework that is able not only to score the relevance of variation in the non-coding genome, but also to associate regulatory variants to specific Mendelian diseases. Genomiser scores variants through either existing methods such as CADD or a bespoke machine learning method and combines these with allele frequency, regulatory sequences, chromosomal topological domains, and phenotypic relevance todiscover variants associated to specific Mendelian disorders. Overall, Genomiser is able to identify causal regulatory variants as thetop candidate in 77% of simulated whole genomes, allowing effective detection and discovery of regulatory variants in Mendelian disease.
Output: Which method is available for whole genome identification of pathogenic regulatory variants in mendelian disease?