You will be given a definition of a task first, then some input of the task.
In this task you will be given a passage and a yes/no question based on the passage. You should answer the question using the information from the passage.

passage: In eukaryotes, the accessibility of large regions of DNA can depend on its chromatin structure, which can be altered as a result of histone modifications directed by DNA methylation, ncRNA, or DNA-binding protein. Hence these modifications may up or down regulate the expression of a gene. Some of these modifications that regulate gene expression are inheritable and are referred to as epigenetic regulation.
question: gene expression may be regulated by altering chromatin structure?
Output:
Yes