Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.

The molecular mechanisms of the vasoconstrictor responses evoked by hydrogen peroxide (H2O2) have not been clearly elucidated in skeletal muscle arterioles.', 'Changes in diameter of isolated, cannulated and pressurized gracilis muscle arterioles (GAs) of Wistar-Kyoto rats were determined under various test conditions. H2O2 (10-100 M) evoked concentration-dependent constrictions in the GAs, which were inhibited by endothelium removal, or by antagonists of phospholipase A (PLA; 100 M 7,7-dimethyl-(5Z,8Z)-eicosadienoic acid), protein kinase C (PKC; 10 M chelerythrine), phospholipase C (PLC; 10 M U-73122), or Src family tyrosine kinase (Src kinase; 1 M Src Inhibitor-1). Antagonists of thromboxane A2 (TXA2; 1 M SQ-29548) or the non-specific cyclooxygenase (COX) inhibitor indomethacin (10 M) converted constrictions to dilations. The COX-1 inhibitor (SC-560, 1 M) demonstrated a greater reduction in constriction and conversion to dilation than that of COX-2 (celecoxib, 3 M). H2O2 did not elicit significant changes in arteriolar Ca(2+) levels measured with Fura-2.
1