Detailed Instructions: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Problem:Question: The state of adaptation characterized by the diminution of the response to the same amount of drug or the need for a higher dose to cause the same degree of pharmacological effect, defines:
Options: <1> The adaptation to a drug. <2> The route of administration. <3> Intoxication <4> Tolerance to a drug <5> Addictive behavior
Solution:
4