Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. Uncle Tom and uncle Sam both have high cholesterol. Uncle Tom is on statin drugs and uncle Sam is not. Which uncle takes an inhibitor of the rate limiting enzyme that decreases blood levels of cholesterol?
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Answer: Tom

Q: Another example of negative feedback has to do with blood glucose levels. When glucose (sugar) levels in the blood are too high, the pancreas secretes insulin to stimulate the absorption of glucose and the conversion of glucose into glycogen, which is stored in the liver. As blood glucose levels decrease, less insulin is produced. When glucose levels are too low, another hormone called glucagon is produced, which causes the liver to convert glycogen back to glucose. Rob is studying medicine in a prestigious university. Today, his professor is teaching about blood glucose levels. He gave example of two patients, patient A and patient B. Patient A had high blood glucose level, but patient B had low blood glucose level. Rob was amazed to find how body keeps its balance. Which patient would secrete more insulin, patient A or patient B?
A: patient A

Question: Scientists think that the earliest flowers attracted insects and other animals, which spread pollen from flower to flower. This greatly increased the efficiency of fertilization over wind-spread pollen, which might or might not actually land on another flower. To take better advantage of this "animal labor," plants evolved traits such as brightly colored petals to attract pollinators. In exchange for pollination, flowers gave the pollinators nectar. Scientists studied two groups of plants. Group F had plants with flowers, group W had plants that fertilize over wind- spread pollen. Flowering plants were more efficient. Which group of plants has fewer brightly colored petals?
Answer: group W

[Q]: In addition to insects, weeds have also been a menace to farmers - just ask anyone with a garden how much they hate weeds. They can quickly compete for water and nutrients needed by other plants. Sure, farmers can use herbicides to kill weeds, but do these chemicals also harm the crops? Can biotechnology help with this issue? Some crops have also been genetically engineered to acquire tolerance to the herbicides - allowing the crops to grow, but killing the weeds. But the lack of cost effective herbicides with a broad range of activity - that do not harm crops - is a problem in weed management. Multiple applications of numerous herbicides are routinely needed to control the wide range of weeds that are harmful to crops. And at times these herbicides are being used as a preventive measure that is, spraying to prevent weeds from developing rather than spraying after weeds form. So these chemicals are being added to crops. This practice is followed by mechanical and/or hand weeding to control weeds that are not controlled by the chemicals. Crops that are tolerant of herbicides would obviously be a tremendous benefit to farmers ( Figure above ). The introduction of herbicide tolerant crops has the potential to reduce the number of chemicals needed during a growing season, thereby increasing crop yield due to improved weed management and decreased harm to the crops. Because of the weed and insect menace villagers from North village decided to use herbicide tolerant crops. South village decided to postpone a decision and kept using regular seeds. Which village reduced the number of chemicals needed during a growing season?
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[A]: North

input: Please answer the following: Scientists think that the earliest flowers attracted insects and other animals, which spread pollen from flower to flower. This greatly increased the efficiency of fertilization over wind-spread pollen, which might or might not actually land on another flower. To take better advantage of this "animal labor," plants evolved traits such as brightly colored petals to attract pollinators. In exchange for pollination, flowers gave the pollinators nectar. Last week, John visited the national park near his city. He saw many flowers. His guide explained him that there are two categories of flowers, category A and category B. Category A flowers spread pollen via wind, and category B flowers spread pollen via animals. Which flower would have lower efficiency of fertilization, catergory A or category B?
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output: category A

Located mostly in the Arctic north polar region in the middle of the Northern Hemisphere, the Arctic Ocean is almost completely surrounded by Eurasia and North America. It is partly covered by sea ice throughout the year and almost completely in winter. The Arctic Ocean's surface temperature and salinity vary seasonally as the ice cover melts and freezes; its salinity is the lowest on average of the five major oceans, due to low evaporation, heavy fresh water inflow from rivers and streams, and limited connection and outflow to surrounding oceanic waters with higher salinities. The summer shrinking of the ice has been quoted at 50%. The US National Snow and Ice Data Center (NSIDC) uses satellite data to provide a daily record of Arctic sea ice cover and the rate of melting compared to an average period and specific past years. John sailed across two oceans last year. First, he sailed across the Atlantic Ocean, which he noted as location A. Then he sailed across the Arctic Ocean, which he noted as location B. He was so amazed by the Arctic Ocean that he sailed across that ocean twice, time C and time D. Time C was in the summer,and time D was in the winter. Would location B have lower or higher evaporation than location A?
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Answer:
lower