Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

Although this therapy is not yet available for patient use, the story makes a point of noting that the cost may well be "stratospheric," should it make it to market. If approved, such treatments are expected to command stratospheric prices. For example, a separate Spark gene therapy for a rare type of childhood blindness, which is on track for Food and Drug Administration clearance soon, could cost $1 million per patient for infusions in both eyes, according to some Wall Street analysts. Still, the therapies can produce at least some offsetting savings. Porteus noted in his editorial that the hemophilia therapy resulted insavings of about $200,000 a year per patient because of the elimination of clotting-factor infusions. The story summarizes the outcome of the small, 10-person trial that dominates this narrative: Lindsey George, the lead investigator and a hematologist at Children's Hospital of Philadelphia, said that nine of the 10 men in the trial didn't experience any bleeding episodes after the gene therapy treatment. The one patient who needed clotting factor because of bleeding used 91 percent less than before, she said. Although the story does not address harms directlyand should haveit does note that one of the worrying side effects of gene therapyspurring the body to attack itselfwas not present in this study. It is clear from the story that the study is small and an "early-stage trial." One source also notes that the researchers tracked individuals in the study for no more than a year and a half, making longer term assessments unavailable. The story could have done more, though, to signal to the reader that, despite the encouraging outcomes of the study, the treatment is still very much under development. The next stagePhase 3 trialsrequires more participants, more careful study design, and takes, on average, three years to complete. The treatment described here, if ultimately proved worthy, could have a profound impact on a serious genetic condition. Independent sources are identified in the story, as are the funders. But missing from the text is information describing linkages between the two fundersSpark Therapeutics and Pfizerand the lead researchers. It's not clear from the story that there is a financial relationship. Individuals coping with hemophilia B have few options, and the story describes the main one: injections of blood-clotting factor to stem runaway bleeding. Since the story notes that the research is at an early stage with only 10 participants, a reader can easily infer that the treatment is not yet available. However, additional information about remaining evaluation stages for this treatment would have been a useful reinforcing addition. Hemophilia B sufferers who see this story will likely be contacting their doctors. The story establishes novelty with this: The researchers presented earlierfindingson the gene therapy a year ago at the American Society of Hematology's annual meeting, but the latest data covers a larger patient group and a longer time period. A news release issued by Children's Hospital of Philadelphia did a good job of describing this study; the Post story could have picked up more of the salient details from that text but reveals independent reporting nevertheless by including sources not connected to the study.
Gene therapy makes a big advance treating hemophilia B blood disorder

The story does include a discussion of price, reporting that a fluoride varnish treatment can cost $23 to $55, while a filling can cost $86 to $606. That's enough to be rated Satisfactory. However, the story also should have stated that those numbers aren't a head-to-head comparison, since the varnish treatment must be repeated many times over many yearswhich would add up. In fact,a cost-effectiveness analysis done by one of the quoted experts concluded the "Caries Management System" he advocates costs almost $1,800 for every cavity or lost tooth prevented. While the story includes links to some studies that report specific results, the only number reported in the story is a reduction in adult tooth fillings of 30 to 50 percent. But without any absolute numbers, this number isn't useful. Is it a cavity a year? A cavity a decade? The story refers to people at "high risk" for cavities, but does not define what that term means. Without some anchoring in absolute numbers, all readers are left with is a vague sense that preventive treatment is "better" for some people, without pinning down how much better or for whom. Fluoride for dental health has been extensively studied for decades and is considered safe, so we'll file this rating as not applicable to the story. But, as some dentists might point out, there is an argument to be made for discussing one knownthough minorrisk: Some people living in areas with naturally high levels of fluoride in their water may experience tooth discoloration or other issues if they are given additional fluoride treatment. The story portrays the evidence for fluoridetreatments as clear and convincing, when there are actually just a few studies, and a lot of expert opinion. That's not to say the experts quoted in the story are wrong, but the story elevates beliefs to the level of evidence-based conclusions. Cavities in adults can cause serious health problems if left untreated, and any new effective treatment or trends in this area is worthy of press coverage. However, the studiesdiscussedin the story focused on a relatively small group of people with unusually high risk of tooth decayand so these results may not apply to the adult population at large, which this piece implies. The story quotes a number of sources discussing this trend in dentistry, instead of just relying on one dentist. But the piece would be more balanced had it included at least one source pointing out that some of the techniques advocated in the story could be overkill or wasteful for many people who are at just average risk for tooth decay. As the piece was written, all the sources are very rosy about more aggressive preventive dental care. We also found via an internet search that sourceJohn Featherstonehas accepted consultation fees from dental companies that make products for these purposes. However, since he wasn't specifically endorsing one of these productsin this story,we'llgive this a pass. The story does not quantify the benefits of these new preventive treatments, or similar approaches, so it fails to give readers a useful comparison with standard dental care or advice for most adultssuch asfluoride toothpastes, community water fluoridation, flossing, and mouthwashes. It is clear that the treatments mentioned in the story are widely available, and we were pleased to see the story went a step further and let us know how insurance impacts availability. The story reports that the concepts are not new, and that fluoride varnishes have normally been the purview of pediatric dentistry, but are now catching on among adult dentists. However, it never really explains why practice would be changing nowdid research spur this change? There is a reference to "more effective preventive techniques," but it's not clear what that means, and how a reader might act on that. This piece doesn't appear to rely on a news release; the reporter interviewed a number of experts and referred to several publications.
No-Drill Dentistry: Fluoride Treatments Can Prevent Cavities In Adults

"In the wake of the fatal police shooting in Ferguson, Mo., Milwaukee Police Chief Edward Flynn was interviewed for nearly an hour on Wisconsin Public Radio about the incident and its implications. At one point during the Aug. 20, 2014 interview, Flynn told host Kathleen Dunn ""there are many reasons why (police) uses of force are dramatically down, and the main one is training."" Then, alluding back to Ferguson, the chief added: ""It's an extraordinarily rare event. But the fact is, (in) 2012, there were 12,197,000 arrests in the United States, OK? And there were 410 uses of deadly force. Now that is, I think, three-thousands of a percent. So, it's still an extraordinarily rare event."" In the comparison Flynn uses, there is one police killing in 0.00003 percent of all arrests -- an even tinier fraction than he suggested. But expressed another way, the 410 is an average of more than one police killing per day. So, what about the two figures themselves: Are they accurate and do they account for all of the people who are killed by police? Renewed focus Around the country, attention to the use of deadly force by police was heightened after Michael Brown, an unarmed 18-year-old, was shot to death on Aug. 9, 2014, in Ferguson, a St. Louis suburb. In Milwaukee, residents held rallies to raise questions about the Brown case and about the April 2014 death of Dontre Hamilton, a 31-year-old who was shot multiple times by a police officer during a struggle in Red Arrow Park in downtown Milwaukee. (In Milwaukee, there was one police killing of a citizen in 2012, four in 2013 and two through late August of 2014, the Police Department told us.) PolitiFact National rated Half True a claim by conservative talk show host Michael Medved that ""more whites than blacks are victims of deadly police shootings."" The claim ignored the fact that there are more than five times more whites than blacks in America. And our colleagues rated as False a statement that an unarmed black person is shot by a police officer every 28 hours. The report that had been cited by CNN pundit Marc Lamont Hill looked at all deaths, not just those of unarmed individuals. And it rolled in some deaths that did not involve police officers. Flynn's claim Flynn, who headed the police departments in Arlington, Va., and Springfield, Mass., before becoming Milwaukee's chief in 2008, is known nationally for his use of data. When we asked for evidence for Flynn's claim, a Milwaukee police spokesman cited two FBI reports. Both are from 2012, the most recent full-year statistics available. There were 12,196,959 arrests across the country in 2012, which means the figure Flynn used -- 12,197,000 -- was rounded up only slightly. The highest numbers of those arrests were for drug abuse violations, driving under the influence and larceny-theft. There were also 410 cases of justifiable homicide in 2012, according to the FBI, which defines justifiable homicide as the killing of a felon by a law enforcement officer in the line of duty. For example: A police officer responding to a bank robbery alarm who shot a suspect after the suspect fired at the officer. But that doesn't taken into account all police killings of citizens. FiveThirtyEight.com, a news website devoted to data analysis, recently reported that the 410 is a minimum figure. The numbers are self-reported by local police agencies and not audited, not all police agencies report those figures to the FBI and the number doesn't include homicides that weren't ruled justifiable. The FBI totals are likely an undercount for another reason, criminologists told us. Researchers who examine police killings of citizens within large metropolitan police departments often find that the number of such incidents recorded by the departments are higher than the number of justifiable homicides reported by the FBI. But the criminologists also noted Flynn's comparison is one legitimate way to measure the frequency of police killings. Our rating Flynn said that in 2012, there were nearly 12.2 million arrests and ""410 uses of deadly force"" by police in the United States. The Milwaukee police chief correctly quotes official FBI statistics on arrests and justifiable homicides by law enforcement officers, although it appears the 410 is an undercount of the number of people killed by police. To comment on this item, go to the Milwaukee Journal Sentinel website."
In 2012, there were nearly 12.2 million arrests and only 410 "uses of deadly force" by police in the United States.