In this task, you're given passages that contain mentions of names of people, places, or things. Some of these mentions refer to the same person, place, or thing. Your job is to write questions that evaluate one's understanding of such references. Good questions are expected to link pronouns (she, her, him, his, their, etc.) or other mentions to people, places, or things to which they may refer.
Avoid questions that can be answered correctly without actually understanding the paragraph. Avoid questions that do not link phrases referring to the same entity. Avoid questions that have multiple answers.

For each of your questions the answer should be one or more phrases in the paragraph. The answer for each question should be unambiguous.

Example input: Context: Architecturally, the school has a Catholic character. Atop the Main Building's gold dome is a golden statue of the Virgin Mary. Immediately in front of the Main Building and facing it, is a copper statue of Christ with arms upraised with the legend "Venite Ad Me Omnes". Next to the Main Building is the Basilica of the Sacred Heart. Immediately behind the basilica is the Grotto, a Marian place of prayer and reflection. It is a replica of the grotto at Lourdes, France where the Virgin Mary reputedly appeared to Saint Bernadette Soubirous in 1858. At the end of the main drive (and in a direct line that connects through 3 statues and the Gold Dome), is a simple, modern stone statue of Mary.
Example output: To whom did the Virgin Mary allegedly appear in 1858 in Lourdes France?
Example explanation: this question is based on the sentence "It is a replica of the grotto at Lourdes, France where the Virgin Mary reputedly appeared to Saint Bernadette Soubirous in 1858".
Q: Context: The Lobund Institute grew out of pioneering research in germ-free-life which began in 1928. This area of research originated in a question posed by Pasteur as to whether animal life was possible without bacteria. Though others had taken up this idea, their research was short lived and inconclusive. Lobund was the first research organization to answer definitively, that such life is possible and that it can be prolonged through generations. But the objective was not merely to answer Pasteur's question but also to produce the germ free animal as a new tool for biological and medical research. This objective was reached and for years Lobund was a unique center for the study and production of germ free animals and for their use in biological and medical investigations. Today the work has spread to other universities. In the beginning it was under the Department of Biology and a program leading to the master's degree accompanied the research program. In the 1940s Lobund achieved independent status as a purely research organization and in 1950 was raised to the status of an Institute. In 1958 it was brought back into the Department of Biology as integral part of that department, but with its own program leading to the degree of PhD in Gnotobiotics.
A:
Work on a germ-free-life ended up in the creation of which Notre Dame institute?