You will be given a definition of a task first, then some input of the task.
Given a scientific passage and an answer, generate a question for the given answer.

Passage: During adolescence, estrogen causes the changes of puberty. It causes the reproductive organs to mature. It also causes other female traits to develop. For example, it causes the breasts to grow and the hips to widen. Answer: estrogen
Output:
What causes the changes of puberty?