In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

[Q]: To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015-January 2016. We found confirmed infection for 19 (8 by reverse transcription PCR and 11 by serologic testing). Infection attack rates varied (2.7%-32.3%) by dormitory building. No deaths occurred. Independent risk factors for infection were direct contact with a confirmed case-patient and sharing a room with a confirmed case-patient; a protective factor was having an air conditioner in the bedroom. For 9 women from whom a second serum sample was collected, antibodies remained detectable at titers >1:20 by pseudoparticle neutralization tests (n = 8) and 90% plaque-reduction neutralization tests (n = 2). In closed high-contact settings, MERS coronavirus was highly infectious and pathogenicity was relatively low.
[A]: EID podcast Tuberculosis Surveillance and Control in Puerto Rico

[Q]: Low cost, high throughput, easy quantitation, and rich descriptions have made gene expression profiling generated by DNA microarrays an optimal approach for describing host transcriptional responses (HTRs). However, efforts to characterize the landscape of HTRs to diverse pathogens are far from offering a comprehensive view. Here, we developed an HTR Connectivity Map based on systematic assessment of pairwise similarities of HTRs to 50 clinically important human pathogens using 1353 gene-expression profiles generated from >60 human cells/tissues. These 50 pathogens were further partitioned into eight robust "HTR communities" (i.e., groups with more consensus internal HTR similarities). These communities showed enrichment in specific infection attributes and differential gene expression patterns. Using query signatures of HTRs to external pathogens, we demonstrated four distinct modes of HTR associations among different pathogens types/class, and validated the reliability of the HTR community divisions for differentiating and categorizing pathogens from a host-oriented perspective. These findings provide a first-generation HTR Connectivity Map of 50 diverse pathogens, and demonstrate the potential for using annotated HTR community to detect functional associations among infectious pathogens.
[A]: Inferring Infection Patterns Based on a Connectivity Map of Host Transcriptional Responses

[Q]: Mycetoma is a neglected tropical disease, endemic in many tropical and subtropical regions, 49 characterised by massive deformity and disability and can be fatal if untreated early and 50 appropriately. Interleukins (IL) -35 and IL-37 are newly discovered cytokines that play an 51 important role in suppressing the immune system. However, the expression of these 52 interleukins in patients with Madurella mycetomatis (M. mycetomatis) induced eumycetoma 53 has not yet been explored. This study aims to determine the levels of the IL-1 family (IL-1, 54 IL-37) and IL-12 family (IL-12, IL-35) in a group of these patients and the association 55 between these cytokines levels and the patients' demographic characteristics. The present, 56 a case-control study was conducted at the Mycetoma Research Centre, Soba University 57 Hospital, University of Khartoum, Sudan and it included 140 individuals. They were divided 58 into two groups; group I: healthy controls [n = 70; median age 25 years (range 12 to 70 59 years)]. Group II: mycetoma patients [n = 70 patients; median age 25 (range 13 to 70 60 years)]. Cytokines levels were measured in sera using enzyme-linked immunosorbent assay 61 (ELISA). 62 There was no significant correlation between the IL-1 and IL-12 levels and the lesions size 63 and disease duration, whereas levels of IL-37 and IL-35 were significantly correlated with 64 that. The analysis of the risk factors of higher circulatory levels of IL-37 in patients of 65 mycetoma showed a significant negative association with IL-1 cytokine, where a unit 66 increment in IL-1 will decrease the levels of IL-37 by 35.28 pg/ml. The levels of IL-37 67 among the patients with a duration of mycetoma infection one year had significantly 68 decreased by an average of 18.45 compared to patients with a mycetoma infection's 69 duration of 5years (reference group). Furthermore, the risk factors of higher levels of IL-35 . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/502609 doi: bioRxiv preprint 70 in mycetoma patients revealed a significant negative association with IL-12, as a unit 71 increment in IL-12 decreases the levels of IL-35by 8.99 pg/ml (p < 0.001). Levels of IL-35 72 among the patients with duration of mycetoma infection one year had significantly 73 decreased (p-value = 0.002) on average by 41.82 compared to patients with a duration of 74 mycetoma infection five years (reference group). In conclusion, this study indicates that 75 both IL-35 and IL-37 are negatively associated with the levels of IL-1 and IL-12 in 76 eumycetoma mycetoma infection; and high levels of IL-37 and IL-35 may have a negative 77 impact on disease progression. 78 79 Authors Summary 80 Mycetoma is a progressive chronic granulomatous fungal or bacterial infection that may 81 result in massive destruction of subcutaneous tissues, muscles and bones. Mycetoma is 82 a neglected disease which is endemic in many tropical and subtropical areas. If the 83 disease is not treated properly, eventually it ends up with amputation and adverse 84 medical, health and socioeconomic effects on patients and the community. 85 Previous data suggested a crucial role of adaptive immunity in host resistance to 86 causative agents and the disease progression. The recently identified IL -35 and IL-37 87 cytokines revealed an important role in immune suppression. Nevertheless, the 88 expression of these interleukins in patients with mycetoma has not yet been 89 investigated. Therefore, the present case-control study aimed to determine the levels of 90 IL-1 family (IL-1, IL-37) and IL-12 family (IL-12, IL-35) in these patients and the 91 association between these cytokines levels and the patients' demographic 92 characteristics. . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/502609 doi: bioRxiv preprint The results of this study showed that the levels of IL-37 and IL-35 were consistently 94 positively correlated with different diameters of mycetoma lesions as well as its duration. 95 However, the levels of IL-1 and IL-12 were consistently negatively correlated with 96 different diameters of lesions and the duration of mycetoma infection. The analysis of 97 the risk factors of higher circulatory levels of IL-37 in patients of mycetoma showed a 98 significant negative association with IL-1 cytokine. Furthermore, the risk factors of 99 higher levels of IL-35 in patients of mycetoma revealed a significant negative 100 association with IL-12. These findings uncover a possible the role of IL-35 and IL-37 in 101
[A]:
Title: 2 The Role of Interleukin-1 cytokine family (IL-1, IL-37) and interleukin-12 cytokine 3 family (IL-12, IL-35) in eumycetoma infection pathogenesis. Authors 7 Corresponding Author