Given the task definition, example input & output, solve the new input case.
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
Example: Paragraph: The severe acute respiratory syndrome (SARS) epidemic originating from China in 2002 was caused by a previously uncharacterized coronavirus that could be identified by specific RT-PCR amplification. Efforts to control future SARS outbreaks depend on the accurate and early identification of SARS-CoV infected patients. A real-time fluorogenic RT-PCR assay based on the 3 -noncoding region (3 -NCR) of SARS-CoV genome was developed as a quantitative SARS diagnostic tool. The ideal amplification efficiency of a sensitive SARS-CoV RT-PCR assay should yield an E value (PCR product concentration increase per amplification cycle) equal to 2.0. It was demonstrated that the 3 -NCR SARS-CoV based RT-PCR reactions could be formulated to reach excellent E values of 1.81, or 91% amplification efficacy. The SARS-CoV cDNA preparations derived from viral RNA extract and the cloned recombinant plasmid both exhibit the identical amplification characteristics, i.e. amplification efficacy using the same PCR formulation developed in this study. The viral genomic copy (or genomic equivalences, GE) per infectious unit (GE/pfu) of SARS-CoV used in this study was also established to be approximate 1200-1600:1. The assay's detection sensitivity could reach 0.005 pfu or 6-8 GE per assay. It was preliminarily demonstrated that the assay could efficiently detect SARS-CoV from clinical specimens of SARS probable and suspected patients identified in Taiwan. The 3 -NCR based SARS-CoV assay demonstrated 100% diagnostic specificity testing samples of patients with acute respiratory disease from a non-SARS epidemic region.
Title: Development and evaluation of an efficient 3 -noncoding region-based SARS coronavirus (SARS-CoV) RT-PCR assay for detection of SARS-CoV
Output: True
The answer is true because the title of the paragraph is correct where it described the development of 3 -noncoding region of SARS-CoV genome and assay efficiently detecting SARS-CoV from clinical specimens.

New input case for you: Paragraph: the virus [9], highlighting the rapid responses of the scientific community to this previously unknown global pathogen. Advancements in synthetic organic chemistry, molecular biology, and informatics have made possible the in vitro and in vivo [10-13]. The term "chemical genetics" has been coined to signify the use of chemicals to per-1 Department of Microbiology 2 Department of Biochemistry turb systematically, and thus determine, the function of proteins in the same way that mutations are used in classical genetics [14-16]. We decided to dissect the pathogenic pathways of the SARS-CoV using chemical Pokfulam, Hong Kong SAR China genetics. We hypothesized that by using forward chemical genetics [15, 16], in which small molecules that in-4 The Aaron Diamond AIDS Research Center 455 First Avenue duce altered phenotypes in cells or organisms are identified and their cellular targets will then be determined New York, New York 10016 subsequently, we will be able to isolate novel small-molecule compounds perturbing the biological pathways that are essential for the pathogenesis of SARS-CoV. Summary The severe acute respiratory syndrome-associated tion with ACE2 [9]. After being internalized into the target coronavirus (SARS-CoV) infected more than 8,000 cells, SARS-CoV undergoes a very rapid replication cypeople across 29 countries and caused more than 900 cle through a series of concerted transcriptional, translafatalities. Based on the concept of chemical genetics, tional, posttranslational, and proteolytic processing we screened 50,240 structurally diverse small moleevents, leading to maturation and release of infective cules from which we identified 104 compounds with viral particles into the culture supernatant [17-19]. We anti-SARS-CoV activity. Of these 104 compounds, 2 speculated that the various biological pathways intarget the SARS-CoV main protease (M pro ), 7 target volved in viral pathogenesis could be perturbed by small helicase (Hel), and 18 target spike (S) protein-angiomolecules using chemical genetic approaches. To extensin-converting enzyme 2 (ACE2)-mediated viral enamine the feasibility of employing chemical genetic try. The EC 50 of the majority of the 104 compounds approaches in SARS-CoV research, we acquired a determined by SARS-CoV plaque reduction assay chemical library (ChemBridge Corporation) of 50,240 were found to be at low micromolar range. Three sestructurally diverse small-molecule compounds that lected compounds, MP576, HE602, and VE607, valivary in functional groups and charges. As the SARSdated to be inhibitors of SARS-CoV M pro , Hel, and viral CoV replicates effectively in Vero cells (African green entry, respectively, exhibited potent antiviral activity monkey kidney cell line) and full cytopathic effects (CPE) (EC 50 10 M) and comparable inhibitory activities in of the infected cells can be observed within 96 hr postintarget-specific in vitro assays. fection, Vero cell CPE was used as a phenotypic indicator of successful viral infection in a cell-based assay to
Title: Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics use of large collections of small molecules (chemical libraries) to investigate protein/chemical interactions
Output:
False