Dwayne Michael Carter Jr. was born on September 27, 1982, and grew up in the impoverished Hollygrove neighborhood of New Orleans, Louisiana. His mother, a cook, gave birth to him when she was 19 years old. His parents divorced when he was 2, and his father permanently abandoned the family. Although Wayne and Birdman have a father-son relationship and Birdman calls Carter his son, Wayne's biological father and namesake (Dwayne Carter) is still alive.

Instead of a follow-up solo album, Lil Wayne reached his audience through a plethora of mixtapes and guest appearances on a variety of pop and hip-hop singles. Of his many mixtapes, Dedication 2 and Da Drought 3 received the most media exposure and critical review. Dedication 2, released in 2006, paired Lil Wayne with DJ Drama and contained the acclaimed socially conscious track "Georgia Bush", in which Lil Wayne critiqued former US president George W. Bush's response to the effects of Hurricane Katrina on the city of New Orleans. Da Drought 3 was released the following year and was available for free legal download. It contained Lil Wayne rapping over a variety of beats from recent hits by other musicians. A number of prominent hip-hop magazines such as XXL and Vibe covered the mixtape. Christian Hoard of Rolling Stone magazine considered the mixtapes Da Drought 3 and The Drought Is Over 2 (The Carter 3 Sessions) "among the best albums of 2007." Despite no album release for two years, Lil Wayne appeared in numerous singles as a featured performer, including "Gimme That" by Chris Brown, "Make It Rain" by Fat Joe, "You" by Lloyd, and "We Takin' Over" by DJ Khaled (also featuring Akon, T.I., Rick Ross, Fat Joe, and Birdman), "Duffle Bag Boy" by Playaz Circle, "Sweetest Girl (Dollar Bill)" by Wyclef Jean (also featuring Akon), and the remix to "I'm So Hood" by DJ Khaled (also featuring T-Pain, Young Jeezy, Ludacris, Busta Rhymes, Big Boi, Fat Joe, Birdman, and Rick Ross). All these singles charted within the top 20 spots on the Billboard Hot 100, Hot Rap Tracks, and Hot R&B/Hip-Hop Songs charts. On Birdman's 2007 album 5 * Stunna, Lil Wayne appeared on the singles "100 Million" and "I Run This" among several other tracks. Wayne also appeared on tracks from albums Getback by Little Brother, American Gangster by Jay-Z, and Graduation by Kanye West and Insomniac by Enrique Iglesias. "Make it Rain", a Scott Storch production that peaked at number 13 on the Hot 100 and number two on the Hot Rap Tracks chart, was nominated for the Grammy Award for Best Rap Performance by a Duo or Group for 2008. Vibe magazine ranked a list of 77 of Lil Wayne's songs from 2007 and ranked his verse in DJ Khaled's "We Takin Over" as his best of 2007, with "Dough Is What I Got" (a freestyle over the beat of Jay-Z's "Show Me What You Got") from Da Drought 3 the second song. At the end of 2007, an MTV poll selected Lil Wayne as "Hottest MC in the Game", The New Yorker magazine ranked him "Rapper of the Year", and GQ magazine named him "Workaholic of the Year". In 2008 he was named "Best MC" by Rolling Stone. Another article, built around Lil Wayne's 2007 mixtape work, cites his creative practice as an example of post performance creative practice.

What was the most popular song from the mixtape?
contained the acclaimed socially conscious track "Georgia Bush",