Detailed Instructions: Given a scientific passage and an answer, generate a question for the given answer.
See one example below:
Problem: Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Solution: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Explanation: The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.

Problem: Passage: After an adaptive defense is produced against a pathogen, typically plasma cells first secrete IgM into the blood. BCRs on naive B cells are of the IgM class and occasionally IgD class. IgM molecules make up approximately ten percent of all antibodies. Prior to antibody secretion, plasma cells assemble IgM molecules into pentamers (five individual antibodies) linked by a joining (J) chain, as shown in Figure 42.23. The pentamer arrangement means that these macromolecules can bind ten identical antigens. However, IgM molecules released early in the adaptive immune response do not bind to antigens as stably as IgGs, which are one of the possible types of antibodies secreted in large quantities upon re-exposure to the same pathogen. Figure 42.23 summarizes the properties of immunoglobulins and illustrates their basic structures. Answer: antibodies
Solution:
After an adaptive defense is produced against a pathogen, typically plasma cells first secrete immunoglobin, which constitutes about ten percent of all what?