In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: In patients with Chronic Obstructive Pulmonary Disease, which treatments listed below are contraindicated due to the effect they cause:
Options: <1> Bronchodilators, both short and long acting. <2> Mucolytics and expectorants to reduce the viscosity of secretions. <3> Oxygen that in the long term reduces the mortality of the patient with COPD. <4> Respiratory depressants such as opioids and barbiturates. <5> Antibiotics for patients with repeated pulmonary infections.
4

Question: It is a stop codon for translation:
Options: <1> AUG. <2> UAU <3> UGA <4> UAC. <5> UGU
3

Question: In the alcaptonuria the defective enzyme can be:
Options: <1> Dihydrobiopterin reductase. <2> Tyrosine aminotransferase. <3> p-hydroxyphenylpyruvate dioxygenase. <4> Homogentisic 1,2-dioxygenase. <5> Fumarilacetoacetasa.
4