Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Abstract: Ewes were treated systemically during the periovulatory period with the antihistamines diphenhydramine (H1-receptor antagonist) and(or) cimetidine (H2-receptor antagonist). None of the treatments prevented ovulation. However, the combination of drugs inhibited subsequent function of the corpus luteum (CL) as assessed by serum measurements of progesterone. Administration of antihistamines did not alter pituitary secretion of LH. Injection of small quantities of diphenhydramine and cimetidine into the antrum of the preovulatory follicle also caused aberrant luteal activity, but no blockade of ovulation. Intrafollicular injection of histamine reversed the inhibitory influence of antihistamines on the CL. Antihistamines suppressed preovulatory thecal edema and antral influx of plasma transudate containing LH. Thus, the effects of antihistamines appear to have been exerted at the follicular level. Function of matured CL was not compromised by peripheral administration of antihistamines. Actions of histamine within the preovulatory ovine follicle do not appear to be a prerequisite for ovulation, but apparently do have an impact on ensuing luteal function. We propose that a hyperemic reaction to histamine in preovulatory follicles enhances vascular filtration of LH. As a consequence, maximal permeation of the avascular granulosal layer of the follicle by LH leads to a normal luteinization response.
Which is the apt title for the abstract? option1: Ovarian function in ewes treated with antihistamines. option2: Therapy-related leukemia and myelodysplastic syndrome: clinical, cytogenetic, and prognostic features.
Ovarian function in ewes treated with antihistamines.

Abstract: In a prospective study, 24 high school football players with isolated Grade III injuries of the medial collateral ligament (MCL) of the knee were treated by conservative management. This included an active rehabilitation program, progressing from immobilization and controlled motion in an orthotic rehabilitation knee brace, to muscle strengthening and agility exercise. A stable knee was achieved in 22 cases; the average recovery time was 29 days. The athletes returned to competitive sports at a mean time of 34 days. These results confirm previous reports of successful nonoperative management of isolated Grade III MCL injuries.
Which is the apt title for the abstract? option1: Nonoperative management of isolated grade III collateral ligament injury in high school football players. option2: Phorbol ester serves as a coepibolin in the spreading of primary guinea pig epidermal cells.
Nonoperative management of isolated grade III collateral ligament injury in high school football players.

Abstract: Hemoperfusion through Amberlite XAD-4 resin column has been shown to effectively remove sedative-hypnotics, analgesics and other drugs causing acute intoxication. There is no appreciable clinical toxicity and dramatic shortening of coma time and possible decrease in mortality may be achieved. Thrombocytopenia and clotting may be diminished by pre-perfusion coating with 2.5% albumin. Albumin coating may facilitate the repeated use of hemoperfusion without any complications. More recently, resin hemoperfusion has been used for procainamide, N-acetylprocainamide and theophylline intoxication achieving exceptionally high clearance rates.
Which is the apt title for the abstract? option1: Resin hemoperfusion for drug intoxication--an update. option2: Nortriptyline in depressed patients with left ventricular impairment.
Resin hemoperfusion for drug intoxication--an update.