instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P.05), and naproxen resulted in significant improvement of LBPI vs placebo (P.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.
answer:
What is the target of tanezumab?

question:
The Eagles looked to win their 6th game in a row against the winless 49ers. The Eagles got off to a slow start, only leading 3-0 after the first quarter. Late in the second quarter, the Eagles blew the game open. Carson Wentz found tight end Zach Ertz for a 1-yard touchdown in the back of the end zone off of a bootleg pass, and Jalen Mills intercepted rookie QB C.J. Beathard and returned it 37 yards for a touchdown. The 49ers appeared to have some life in the third quarter, following a Carson Wentz interception, leading to a Matt Breida 22 yard touchdown reception. However, the Eagles responded, with Wentz connecting with Alshon Jeffery for a 53-yard touchdown, putting the game out of reach. The Eagles went on to win 33-10 and advanced to 7-1 on the season. Despite the win, the Eagles played a sloppy game in a rainy afternoon at the Linc.
answer:
Which player had the longest touchdown catch?

question:
New research shows how kids' brains reorganize as they learn math. All the time you spent memorizing multiplication tables may have made you a better mathematician, according to a new study. A team of scientists from Stanford University, in California, have shown how the brain reorganizes itself as kids learn math. After a certain amount of time spent practicing math, kids can put away the calculator . They don't even need to count on their fingers. They simply know the answers to subtraction , addition, and multiplication facts. The quicker kids can recall basic math facts, the easier it is for them to solve more complicated math problems. The Stanford University researchers observed the brain activity of 28 students aged 7to 9 for the study. They took scans of the students' brains as the students solved math calculations without the help of a calculator, pen or paper. A calculation--three plus four equals seven, for example--flashed on a screen. The students pushed a button to say if the answer was right or wrong. The scientists also recorded the response speed, and what parts of the brain became active as the kids pushed the button. These observations showed a process called fact retrieval . Rather than using their fingers to count, or writing out answers on a piece of paper, the students pulled the answers from memory. It's as if the answers to basic math problems are kept in a long-term storage area in the brain, which was built from repetition. "Experience really does matter," said Dr. Kathy Mann Koepeke. Children make the shift from counting to fact retrieval when they are 8 to 9 years old, the study shows. This is the time when most students are learning basic addition and subtraction. When kids have basic math facts memorized, the brain has more free space to learn more complicated math. This process has benefits for the future. The study shows as kids grow older, their answers rely more on memory and become quicker and more accurate. Less brain activity is devoted to counting. Some children make this shift quicker than others.
answer:
What plays a key role in solving a math problem?