Q: Mark Twain, the famous American writer, was traveling in France. Once he was going by train to Dijon. That afternoon he was very tired and wanted to sleep, so he asked the conductor to wake him up when they came to Dijon. But first he explained that he was a very heavy sleeper. "I'll probably protest loudly when you try to wake me up," he said to the conductor, "but do not take any notice, just put me off the train anyway." Then Mark Twain went to sleep. Later, when he woke up, it was night-time and the train was in Paris already. He realized at once that the conductor had forgotten to wake him up at Dijon. He was very angry. He ran up to the conductor and began to shout at him."I have never been so angry in all my life," Mark Twain said. The conductor looked at him calmly. "You are not half so angry as the American whom I put off at Dijon," he said.

1. Dijon
2. by train
3. the conductor
4. Mark Twain
5. No
6. afternoon
7. America
8. France
9. No
10. a very heavy sleeper
11. No
12. protest loudly
13. No
14. put me off the train anyway
15. No
16. in Paris
17. angry
18. the conductor
19. the American whom I put off at Dijon
20. Yes

Numbered questions:
1. Where was the stop he wanted off at?
2. what kind of vehicle was he in?
3. whom did he ask to awaken him?
4. who is this sleepy person?
5. was he traveling by night?
6. what time of day?
7. where is Twain from?
8. what country is he in now?
9. is he a light sleeper?
10. what kind is he?
11. does he wake up silently?
12. what does he think he'll do when he is awoken?
13. does he want the conductor to be concerned with that?
14. what does he want him to do?
15. does the conductor do this?
16. where does Twain awaken?
17. how does he feel about this?
18. who does he yell at?
19. who is angrier than Twain?
20. was the conductor calm about this?

Q: All antidepressant drugs are not created equal, according to the authors of one of the few studies that have ever systematically analyzed and compared "new generation" medicines for treating depression.

What qualities are important in an anti-depressant? Efficacy? Tolerance? Side effects? Cost?

In the analysis of 12 drugs, two came out on top as the most effective and best tolerated as first-line treatments: sertraline (Zoloft) and escitalopram (Lexapro). Venlafaxine (Effexor) and mirtazapine (Remeron) rounded out the top four for effectiveness, but venlafaxine was also among the four drugs patients were most likely to quit taking because of side effects. Reboxetine (Edronax) was less effective than the rest.

While psychiatrists treating depressed patients every day have had a sense of which medications are best, the current study "nails it," says Sagar V. Parikh, M.D., of the University of Toronto. Parikh, who wrote a comment accompanying the study that is published in the current issue of The Lancet, says the findings have "enormous implications" because, for the first time, they offer doctors an evidence-based, unbiased way to recommend treatment. And, he adds, they give patients a "gold standard of reliable information," especially since the study's authors plan to make their findings available free on the Web.

Not so fast, says Gerald Gartlehner, M.D., M.P.H., who coauthored a review of the benefits and risks of the same 12 drugs published last November in the Annals of Internal Medicine. He and his colleagues concluded, based on their review done while Gartlehner was at the RTI-UNC Evidence-Based Practice Center in Chapel Hill, North Carolina., that there was no clinically meaningful evidence that any one of the drugs was better than the rest. Instead, they argued, decisions on which drug to use should be based on factors such as cost and side effects.

1. 12
2. antidepressants
3. no
4. yes
5. sertraline and escitalopram
6. yes
7. Reboxetine
8. yes
9. The Lancet
10. yes
11. Sagar V. Parikh
12. a doctor
13. University of Toronto
14. no
15. Gerald Gartlehner
16. yes
17. at the RTI-UNC
18. North Carolina
19. none the drugs was better than the rest.
20. yes

Numbered questions:
1. How many different drugs were analyzed?
2. And what kind of drugs were they?
3. Were they all found to be equally effective?
4. Were any identified as being the most effective?
5. Which?
6. Were any of them definitively the least effective?
7. Which one?
8. Did they print the results in a journal?
9. Which one?
10. Were the results important?
11. Who suggested that?
12. And what's his profession?
13. Where does he work?
14. Is there universal agreement that the results were important?
15. Who believes that?
16. Do his coworkers believe it too?
17. Where did they do their work leading to that conclusion?
18. In what state?
19. And what do their results suggest on the other hand?
20. Did they publish their work too?

Q: Chapter 9

TWO PLACES VACATED

Set down by the omnibus at the corner of Saint Mary Axe, and trusting to her feet and her crutch-stick within its precincts, the dolls' dressmaker proceeded to the place of business of Pubsey and Co. All there was sunny and quiet externally, and shady and quiet internally. Hiding herself in the entry outside the glass door, she could see from that post of observation the old man in his spectacles sitting writing at his desk.

'Boh!' cried the dressmaker, popping in her head at the glass-door. 'Mr Wolf at home?'

The old man took his glasses off, and mildly laid them down beside him. 'Ah Jenny, is it you? I thought you had given me up.'

'And so I had given up the treacherous wolf of the forest,' she replied; 'but, godmother, it strikes me you have come back. I am not quite sure, because the wolf and you change forms. I want to ask you a question or two, to find out whether you are really godmother or really wolf. May I?'

'Yes, Jenny, yes.' But Riah glanced towards the door, as if he thought his principal might appear there, unseasonably.

'If you're afraid of the fox,' said Miss Jenny, 'you may dismiss all present expectations of seeing that animal. HE won't show himself abroad, for many a day.'

'What do you mean, my child?'

'I mean, godmother,' replied Miss Wren, sitting down beside the Jew, 'that the fox has caught a famous flogging, and that if his skin and bones are not tingling, aching, and smarting at this present instant, no fox did ever tingle, ache, and smart.' Therewith Miss Jenny related what had come to pass in the Albany, omitting the few grains of pepper.

1. The old man
2. Miss Wren,
3. Saint Mary Axe
4. the dolls
5. Jenny
6. 'Mr Wolf
7. to the place of business
8. unknown
9. His principal?
10. Jenny

Numbered questions:
1. Who took their glasses off?
2. who was sitting beside a jew?
3. What corner were they at?
4. Who's dressmaker was it?
5. Who was the old man speaking with?
6. What was the old man's name?
7. where was the dressmaker headed?
8. Who's place of business?
9. Who was hiding in the door?
10. Who wanted to ask a question ?