Given the task definition and input, reply with output. Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Question: Do thymidylate synthase and p53 expression in primary tumor predict chemotherapy outcome in metastatic colorectal carcinoma?
Answer: Immunohistochemical investigation of TS and p53 of the primary tumour is not useful to predict the outcome of palliative chemotherapy in ACRC. Instead, TS can be regarded as a marker for prediction of time to recurrence.
no