Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Example Input: Abstract: Forty-two patients with intransit metastases of melanoma in a limb were treated by isolated regional perfusion chemotherapy using mechlorethamine (nitrogen mustard). Group 1 (n = 12) underwent treatment at low dose, less than 0.35 mg/kg, or low temperature, less than 38 degrees C. Group 2 (n = 30) received higher doses, 0.35 to 0.6 mg/kg, plus heat at 38 degrees C to 41 degrees C. No patient had evidence of disease outside the limb at the time of perfusion. The median follow-up time was 48 months (range, 1 to 9 years). Of the 42 patients, 29 had measurable lesions that responded as follows: group 1, complete response (CR) in two of ten and partial response (PR) in none; group 2, CR in six of 19 and PR in six of 19. The combined CR and PR rate of 12 of 19 in group 2 was significantly higher than that of group 1 (P less than .05). CR lasted only 2 months in the two patients of group 1, but persisted in the six patients of Group 2, four of whom are still alive free of disease at 16, 21, 33, and 40 months. Relapse-free control of disease in the limb was achieved in 36% of the patients in group 2 at 24 months, compared with 0% in group 1 (P less than .05). An overall survival of 74% at 48 months was observed in group 2, significantly higher than that of 64% for group 1 (P less than .05). The status of the regional lymph nodes (RLN) and the number of metastases did not affect tumor response. However, 77% of RLN-negative patients survived 48 months, in contrast to only 38% of RLN-positive patients (P less than .05). One patient died postoperatively of myocardial infarction. No serious systemic toxicity developed. Two patients who underwent repeat salvage perfusions developed a reversible peripheral neuropathy in the limb. Limb function was good after treatment, and dramatically improved in patients who had advanced satellitosis that responded to treatment. These results suggest that heated limb perfusion using mechlorethamine at an adequate dose can offer long-term control of intransit metastases in approximately one third of these patients, with preservation of good limb function and possible prolongation of survival.
Which is the apt title for the abstract? option1: Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard). option2: Central nervous system metastases in epithelial ovarian carcinoma.
Example Output: Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard).

Example Input: Abstract: An analysis was completed of 34 patients with dementia who attended a mixed medical day care program over a five-year period. The parameters reviewed included age, home situation, diagnosis, incidence of co-existent medical disorders, management by the social worker, nurses and neuropsychiatrist, the extent of social and program participation, length of stay, and disposition. There was a high incidence of medical problems which were managed effectively because of close nursing observation, availability of ancillary services, specialty clinics, and frequent communication with the community physicians. The social worker assisted families with the management of long-term planning for the dementia patients and the entire social-nursing-recreational therapy team devised programs which encouraged the patients to function at an optimum level. Neuropsychiatric management, including drug therapy, was an integral part of the program. Despite the fact that the dementia patients were at high risk, with an average age of 81 years the average duration of attendance was two years four months and only nine of the 34 patients ultimately required nursing home placement. It was concluded that the day care program served as a resource which devised, integrated, and supervised, in cooperation with the community physicians, the support network and management strategies for the dementia patients.
Which is the apt title for the abstract? option1: Treatment of dementia in a medical day care program. option2: Fire without smoke [news]
Example Output: Treatment of dementia in a medical day care program.

Example Input: Abstract: Prepregnancy weight status and weight gain during pregnancy are major independent variables associated with infant birth weight. This study quantitated the influence of weight gain on birth weight and identified rates and total amounts of weight gain related to the birth of healthy-sized infants to healthy low-income women who entered pregnancy underweight, at normal weight, overweight, or obese. Data used in the study were obtained from randomly sampled prenatal health records from Maternal and Infant Care (MIC) projects in Cleveland and Minneapolis. Subsamples of healthy mothers who delivered healthy-sized infants were identified from each sample, and rates and total amounts of weight gain by prepregnancy weight status group were calculated. There were 384 healthy mother and healthy-sized infant pairs in the Cleveland subsample and 75 such pairs in the Minneapolis sample. Multiple regression analysis revealed that the influence of prenatal weight gain and birth weight varied depending on prepregnancy weight status. Prenatal weight gains related to the birth of healthy-sized infants (newborns with birth weights of 3,000 to 4,500 gm) to healthy mothers in the Cleveland MIC sample averaged 33 lb for underweight, 32 lb for normal weight, 29 lb for overweight, and 19 lb for obese women. Except for obese women, rates and total amount of weight gain associated with the birth of healthy-sized infants were equivalent for the two samples.
Which is the apt title for the abstract? option1: Prenatal weight gains related to the birth of healthy-sized infants to low-income women. option2: A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor.
Example Output:
Prenatal weight gains related to the birth of healthy-sized infants to low-income women.