Definition: Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.
Input: Paragraph: We think it's too early to guess at what any therapy based on this technique would cost, so we won't flag the story for not mentioning costs. The story says that the therapy resulted in"increased platelet counts" and "improvement of some immune-system cells." The story should have provided quantitative data and tried to explain what these changes might mean for patients. Another problem is that the story didn't tell us how longthe patients were followed and how long the benefits lasted. The effects of some gene therapies fade with time because the cells injected withDNA by viruses ultimately die and stop producing the therapeutic protein. The story acknowledged early on and prominently that one of the study participants developed leukemia, which may have been related to the new treatment. The story probably should have mentioned that other harms might become apparent as these patients are followed further or as more patients are studied. However, we think the study went far enough to earn a satisfactory. Although the story was not grossly imbalanced and did feature some restraining quotes about the early stage of theresearch, we don't think itwent far enough in explaining just how preliminary this research, and the report upon which the story is based, are. Here's where we think the story fell short: Again, while the story's coverage was not overtly misleading, we thinkdiscussion of theseissues would have put additional (and appropriate) emphasis on the need for caution when interpreting the results. The story didn't exaggerate the consequences of Wiskott-Aldrich syndrome. The story included interviews with two independent experts who weren't involved with the study. The storydiscusses one of the primaryexisting treatments forWiskott-Aldrich syndrome: bone marrow transplants. The story's muddled overviewof this treatment is likely to leave readers confused, however. The story starts off its description bysaying that suchtransplants, if they succeed, "basically cure thedisease."It then goes on to list a number ofserious complications that canplague even apparently successfultransplants. So the childrentreated via transplantsound like they probably aren't "cured"as the story initially states. We'll call it satisfactory, but we wish the story was a bit clearer on this point. The story never explicitly addresses the availability of this new technique or how close it may be to approval. However, it doesnote that the research represents justa "first step" and "proof of concept" for the new approach. Although we would like to have seena more direct comment about the many years of testing that lie ahead for any therapy based on this technique, we think most readerswill understand that this is preliminary research and not something they're likely to have access to anytime soon. The story never mentioned that gene therapy using viral vectors is being studied for the treatment of a variety of other hereditary diseases as well as cancer. Importantly, this research has shown that it is extremelydifficult to develop effective therapies based on viral vectors context that would have been valuable in this story. This story doesn't appear to be based on a news release. Claim: Gene Therapy Corrected Rare Bleeding Disorder: Study
Output:
This story relayed the findings of a very preliminary studyon a new treatment for Wiskott-Aldrich syndrome a rare genetic disorder that leads to serious immune system deficiencies and problems with blood clotting. Whilethe story did convey somecaution about theearly stage of this research and the potential formajor side effects, it didn't provide quite enough detail to satisfy many of our criteria. A more thorough investigation would haveemphasized just how far this technology has to go before it can be widely adopted. Because of its devastating effects on the immune system,Wiskott-Aldrich syndrome puts sufferersat increased risk of death from infections and cancer. Although bone marrow transplants can be an effective and durabletreatment, many children have problems finding a good match. In addition, bone marrow transplantscome with a host of serious risks and are nota treatment option for everyone. New treatments, such as the experimental gene therapy discussed in this story, are badly needed.