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Often, large multinational corporations exhibit vertical integration, participating in a broad range of drug discovery and development, manufacturing and quality control, marketing, sales, and distribution. Smaller organizations, on the other hand, often focus on a specific aspect such as discovering drug candidates or developing formulations. Often, collaborative agreements between research organizations and large pharmaceutical companies are formed to explore the potential of new drug substances. More recently, multi-nationals are increasingly relying on contract research organizations to manage drug development.
What are smaller organizations responsible for?
A: focus on a specific aspect such as discovering drug candidates or developing formulations

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Southampton used to be home to a number of ferry services to the continent, with destinations such as San Sebastian, Lisbon, Tangier and Casablanca. A ferry port was built during the 1960s. However, a number of these relocated to Portsmouth and by 1996, there were no longer any car ferries operating from Southampton with the exception of services to the Isle of Wight. The land used for Southampton Ferry Port was sold off and a retail and housing development was built on the site. The Princess Alexandra Dock was converted into a marina. Reception areas for new cars now fill the Eastern Docks where passengers, dry docks and trains used to be.
What location that was once filled with passengers, dry docks, and trains is now a holding area for new cars?
A: Eastern Docks

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In 1562 Francisco de Ibarra headed a personal expedition in search of the mythical cities of Cibola and Quivira; he traveled through the present-day state of Chihuahua. Francisco de Ibarra is thought to have been the first European to see the ruins of Paquime. In 1564 Rodrigo de Rio de Loza, a lieutenant under Francisco de Ibarra, stayed behind after the expedition and found gold at the foot of the mountains of the Sierra Madre Occidental; he founded the first Spanish city in the region, Santa Barbara in 1567 by bringing 400 European families to the settlement. A few years later in 1569 Franciscan missionaries led by Fray Agustin Rodriguez from the coast of Sinaloa and the state of Durango founded the first mission in the state in Valle de San Bartolome (present-day Valle de Allende). Fray Agustin Rodriguez evangelized the native population until 1581. Between 1586 and 1588 a epidemic caused a temporary exodus of the small population in the territory of Nueva Vizcaya.
Which cities was Ibarra looking for?
A: Cibola and Quivira

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The Ordovician Period started at a major extinction event called the Cambrian-Ordovician extinction events some time about 485.4 1.9 Ma. During the Ordovician the southern continents were collected into a single continent called Gondwana. Gondwana started the period in the equatorial latitudes and, as the period progressed, drifted toward the South Pole. Early in the Ordovician the continents Laurentia, Siberia and Baltica were still independent continents (since the break-up of the supercontinent Pannotia earlier), but Baltica began to move toward Laurentia later in the period, causing the Iapetus Ocean to shrink between them. Also, Avalonia broke free from Gondwana and began to head north toward Laurentia. The Rheic Ocean was formed as a result of this. By the end of the period, Gondwana had neared or approached the pole and was largely glaciated.
Which event precipitated the Ordovician period?
A:
the Cambrian-Ordovician extinction