Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
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Question: Question: Does the tissue Doppler imaging derived post-systolic velocity notch originate at the aortic annulus?
Answer: The AA represents the site of the earliest onset and maximal amplitude of the PSN on the longitudinal velocity curve suggesting its mechanism to be that of an energy release at the instant of the aortic valve closure causing an apically directed acceleration of the myocardium. A substantial number of healthy subjects exhibit a second PSN spike predominantly at the level of the AA. Its mechanism remains to be elucidated.

Answer: yes

Question: Question: Does vitamin E supplementation alter physiological performance at fixed blood lactate concentrations in trained runners?
Answer: Daily VE supplementation for 35 days does not enhance or impair physiological performance at fixed blood lactate concentrations. Long-term VE supplementation for the purposes of performance enhancement is not recommended.

Answer: no

Question: Question: Does hippocampal laminar distribution of tau relate to Alzheimer 's disease and age of onset?
Answer: Phospho-tau pathology, when prominent within both IML and OML, is associated with CERAD diagnosis of Definite AD and earlier age of onset in AD. Laminar patterns of tau deposition reflect regional involvements during disease course.

Answer:
yes