Given an abstract of a paper, generate a title for this paper such that conveys the key focus of the paper.
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Question: Abstract: The optimal method of anticoagulation in children with mechanical heart valves is controversial. Between 1975 and 1986, aspirin or aspirin with dipyridamole has been used for anticoagulation in children receiving a mechanical aortic valve at the University of California, San Francisco. Fifty-one patients (ages 1 to 23 years, mean 12.9 years) were treated with aspirin (n = 45) or aspirin with dipyridamole (n = 6) and observed a mean of 36.5 months (range 3 to 100 months). There were four late deaths: two from endocarditis and two from other medical problems, but none related to thrombosis or embolus. Follow-up was accomplished by direct contact with the patient, parent, or referring physician. Two patients (3.9%) were lost to late follow-up. One minor neurologic event occurred perioperatively and resolved spontaneously. There were no postoperative thromboembolic events. Eleven asymptomatic children were recently studied by magnetic resonance imaging or computed axial tomography of the brain and had no evidence of prior silent cerebral thromboembolic defects. There were four patients (5.9%) who had minor hemorrhagic complications: Three patients had nosebleeds and one patient had an upper gastrointestinal hemorrhage. Five patients were changed to warfarin anticoagulation: the patient with upper gastrointestinal hemorrhage and four older patients because of physician preference, all after uncomplicated aspirin therapy. There were no mechanical valve failures, although one patient required reoperation 9 months later for perivalvular leak. All children have remained in normal sinus or paced rhythm during follow-up. These results show that children with mechanical aortic valves in normal sinus rhythm can be safely treated with aspirin (or aspirin with dipyridamole) with little risk of thromboembolic events, valve thrombosis, or valve failure. Hemorrhagic complications resulting from aspirin are minor and easily treated.

Answer: Aspirin anticoagulation in children with mechanical aortic valves.

Question: Abstract: The association between the morphometric dimensions of the external nose, including the thickness of the soft tissues, and various craniometric measurements has been examined on a sample of lateral radiographs of 154 males and 199 females from Vienna, Austria. In addition, the influence of age on morphometric dimensions and the soft tissue cover was tested. Multiple stepwise regression analysis revealed that nasal height and nasal length are best predicted by the dimensions of the skull, whereas nasal depth and the thickness of the soft tissues is greatly influenced by age. In males, over 50% of the variance of nasal height and nasal length were accounted for by the height of the bony nose and the prominence of the ossa nasalia, and in females it was about 40%. Although the thickness of the soft tissue is dependent on exogenous factors, such as nutrition, mimicry, and so forth, the dimensions of the bony nose apparently also influence the skin depths to some extent. High and prominent noses were found to have a thinner layer of soft tissue over the nasal bones than short and less prominent ones. It thus seems as if there is a tendency of the soft tissue cover to adjust to disharmonies of the bony profile.

Answer: An appraisal of plastic reconstruction of the external nose.

Question: Abstract: To determine how various inheritance patterns and responses to splenectomy relate to erythrocyte spectrin deficiencies in hereditary spherocytosis, we measured the spectrin content of erythrocytes by radioimmunoassay in 33 patients with this disease. Patients with the dominant form of hereditary spherocytosis generally had mild anemia, with spectrin at 63 to 81 percent of normal levels. Patients with the nondominant form of the disease had anemia ranging from severe to mild, with corresponding spectrin levels of 30 to 74 percent; their siblings were affected similarly. Distantly related homozygotes had different clinical severities with correspondingly different spectrin levels. The parents and offspring of patients with the nondominant form were clinically normal but consistently had subtle erythrocyte abnormalities. Spectrin levels in all patients were inversely related to osmotic fragility (P less than 0.0001), and they were also correlated with the clinical response to splenectomy: patients with spectrin levels above 70 percent achieved normal blood counts, those with levels of 40 to 70 percent had compensated hemolysis, and those with levels below 40 percent improved but remained anemic (P less than 0.0001). We conclude that the inheritance pattern and response to splenectomy in hereditary spherocytosis reflect erythrocyte spectrin deficiencies as determined by radioimmunoassay.

Answer:
Inheritance pattern and clinical response to splenectomy as a reflection of erythrocyte spectrin deficiency in hereditary spherocytosis.