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By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.

Who identified the active substance?
Answer: John Abel
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A second biotechnology district is being planned for the median strip on Frontage Road, on land cleared for the never-built Route 34 extension. As of late 2009, a Pfizer drug-testing clinic, a medical laboratory building serving Yale New Haven Hospital, and a mixed-use structure containing parking, housing and office space, have been constructed on this corridor. A former SNET telephone building at 300 George Street is being converted into lab space, and has been so far quite successful in attracting biotechnology and medical firms.

When was the opening of first building in the second biotech district?
Answer: late 2009
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By developing commercial centres and routes, encouraging people to extend the area of cultivated land in the country and international trade through its dominions, the state performed basic economic functions in the Empire. But in all this the financial and political interests of the state were dominant. Within the social and political system they were living in Ottoman administrators could not have comprehended or seen the desirability of the dynamics and principles of the capitalist and mercantile economies developing in Western Europe.

The development of what caused people to expand areas of cultivation in the Ottoman Empire?
Answer:
commercial centres and routes