Orci was born in Mexico City on July 20, 1973, to a Mexican father and a Cuban mother. His mother immigrated to the United States with her parents after Fidel Castro came to power. Orci grew up in Mexico, and moved with his family to the United States at the age of 10. He was raised in Texas, Los Angeles and Canada.

Orci and Kurtzman were asked to write the script for a new Star Trek film, but initially turned it down despite Orci being a fan of the series. Orci suggested rebooting the timeline as seen previously in the films and television series, and adding the return of Leonard Nimoy as Spock from Star Trek: The Original Series. He considered the first two films in the reboot series to be the origin story for the crew, and that the third film would start where the crew was at the beginning of Star Trek: The Original Series. Orci felt that the relationship between the James T. Kirk and the younger Spock was reflective of the partnership of himself and Kurtzman, he said that "We didn't even realize we were writing about ourselves until we were halfway through the script, that was a little embarrassing. Star Trek was profitable at the domestic box-office, resulting in a sequel being greenlit by the studio and Kurtzman and Orci being asked to write it. The studio set aside a larger budget for the sequel, which was revealed by Orci in an interview with TrekMovie.com. Orci ruled out the "hero quitting" staple of a second movie, which had featured in the Transformers sequel, saying that the crew of the Enterprise were committed and that type of story does not have to apply to all sequels. During the buildup to the film, called Star Trek Into Darkness, Orci was one of the production team who didn't give much away about the villain in the film and denied that Benedict Cumberbatch was to play Khan Noonian Singh. The criticism of the sequel resulted in Orci posting controversial comments on a Star Trek fan site. In response to a fan upset over Into Darkness, Orci called him a "shitty fan". He later apologized and deactivated his Twitter account.

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