In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Q: NF-jB, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-jB signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-jB, and this activation was found to be mediated through the MyD88 pathway. Infection of IKKb -/murine embryo fibroblasts (MEFs), which are deficient in NF-jB signalling, resulted in lower virus titre, less cytopathic effect, and reduced expression of viral proteins. These findings implicate the MyD88 pathway in EAV-induced NF-jB activation and suggest that NF-jB activation is essential for efficient replication of EAV.
A:
NF-jB activation by equine arteritis virus is MyD88 dependent and promotes viral replication