The answer: yes
The question is: Was the man who played the male lead in Mrs. Doubtfire known for his humour?
The rationale is: Robin Williams played the male lead in Mrs. Doubtfire. Robin Williams had a prolific standup and film comedy career.

The answer: no
The question is: Would the host of The Colbert Report be likely to vote for Trump?
The rationale is: The host of the Colbert report is Stephen Colbert. Stephen Colbert has spoken against Donald Trump multiple times on various platforms.

The answer: no
The question is: Is Olivia Newton-John hyphenated celebrity name with most letters?
The rationale is: Olivia Newton-John has sixteen letters in her name. Actress Catherine Zeta-Jones has 18 letters in her name. Actor Joseph Gordon-Levitt has 18 letters in his name.

The answer: no
The question is: Does Bombyx mori have a monopoly over silk production?
The rationale is: A monopoly refers to the exclusive supply of a good. The Bombyx mori is a moth famous for its silk production. Spiders, beetles, caterpillars, and fleas produce silk. Wild silk produced by caterpillars has been used in China, Europe, and South Asia since antiquity.