Problem: I know that the answer to the question "Where are Madonna's fitness centers located?" is in "Madonna released the Material Girl clothing line, which she designed with her daughter, Lourdes. The 1980s inspired clothing line, borrowed from Madonna's punk-girl style when she rose to fame in the 1980s, was released under the Macy's label. Madonna also opened a series of fitness centers around the world named Hard Candy Fitness. In November 2011, Madonna and MG Icon announced the release of a second fashion brand called Truth or Dare by Madonna to include footwear, underclothing, and accessories. She also directed her second feature film, W.E., a biographic about the affair between King Edward VIII and Wallis Simpson; it was co-written with Alek Keshishian. Critical and commercial response to the film was negative. Madonna contributed the ballad "Masterpiece" for the film's soundtrack, which won her a Golden Globe Award for Best Original Song.". Can you tell me what it is?

A: around the world

Problem: Given the question: I know that the answer to the question "what is the standard threshhold for being subject to the Orphan Drug Act?" is in "There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases involving fewer than 200,000 patients in the United States, or larger populations in certain circumstances are subject to the Orphan Drug Act. Because medical research and development of drugs to treat such diseases is financially disadvantageous, companies that do so are rewarded with tax reductions, fee waivers, and market exclusivity on that drug for a limited time (seven years), regardless of whether the drug is protected by patents.". Can you tell me what it is?
++++++++++++++++++++++++++++++++
The answer is:
200,000 patients

input question: I know that the answer to the question "What is the differentiating feature between alae and legions?" is in "Rome's military confederation with the other peoples of the Italian peninsula meant that half of Rome's army was provided by the Socii, such as the Etruscans, Umbrians, Apulians, Campanians, Samnites, Lucani, Bruttii, and the various southern Greek cities. Polybius states that Rome could draw on 770,000 men at the beginning of the Second Punic War, of which 700,000 were infantry and 70,000 met the requirements for cavalry. Rome's Italian allies would be organized in alae, or wings, roughly equal in manpower to the Roman legions, though with 900 cavalry instead of 300.". Can you tell me what it is????
output answer: 900 cavalry instead of 300

I know that the answer to the question "What is between Minehead and Brean Down?" is in "The main coastal towns are, from the west to the north-east, Minehead, Watchet, Burnham-on-Sea, Weston-super-Mare, Clevedon and Portishead. The coastal area between Minehead and the eastern extreme of the administrative county's coastline at Brean Down is known as Bridgwater Bay, and is a National Nature Reserve. North of that, the coast forms Weston Bay and Sand Bay whose northern tip, Sand Point, marks the lower limit of the Severn Estuary. In the mid and north of the county the coastline is low as the level wetlands of the levels meet the sea. In the west, the coastline is high and dramatic where the plateau of Exmoor meets the sea, with high cliffs and waterfalls.". Can you tell me what it is?
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Answer: coastal area

Q: I know that the answer to the question "In what way is developing drugs to treat orphan diseases disadvantageous?" is in "There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases involving fewer than 200,000 patients in the United States, or larger populations in certain circumstances are subject to the Orphan Drug Act. Because medical research and development of drugs to treat such diseases is financially disadvantageous, companies that do so are rewarded with tax reductions, fee waivers, and market exclusivity on that drug for a limited time (seven years), regardless of whether the drug is protected by patents.". Can you tell me what it is?
A: financially

[Q]: I know that the answer to the question "A nationalist movement developed in the 19th century because of increased access to what?" is in "As a result of the abolition of serfdom and the availability of education to the native Estonian-speaking population, an active Estonian nationalist movement developed in the 19th century.[citation needed] It began on a cultural level, resulting in the establishment of Estonian language literature, theatre and professional music and led on to the formation of the Estonian national identity and the Age of Awakening. Among the leaders of the movement were Johann Voldemar Jannsen, Jakob Hurt and Carl Robert Jakobson.". Can you tell me what it is?
****
[A]:
education