In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Mouse hepatitis virus, a coronavirus, was rescued from latently infected mouse neuroblastoma cells by polyethylene glyeol-induced fusion to permissive cells. The isolated viruses grew to equal or higher titers than parental JHM virus at 39" but were restricted in replication at 32" and hence were cold-sensitive mutants. Neither isolate synthesized RNA at the nonpermissive temperature (32"), and temperature shift experiments indicated that the restrictive cold-sensitive step in replication occurred during an early viral function. The isolates were unable to complement each other at 32". Although coinfection between each mutant and parental JHM virus often resulted in decreased yields of both infecting viruses, interference could not be convincingly demonstrated. Both mutants were more thermostable than parental JHM virus and could be distinguished from each other and from parental JHM virus by their thermal inactivation kinetics. The isolates were obtained from single cell clones and therefore presumed to be homogeneous; however, thermal inactivation of one (S-3JHM) indicated the possible existence of a second population. Subclones of virus prepared from each isolate were also found to be thermally stable and to retain the cold sensitive defect. No indication of a second ~pulation of S-3JHM virus was detected.
Title: Characterization of the Cold-Sensitive Murine Hepatitis Virus Mutants Rescued from Latently Infected Cells by Cell Fusion

A: True
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Q: Paragraph: DNA vaccines present one of the most cost-effective platforms to develop global vaccines, which have been tested for nearly three decades in preclinical and clinical settings with some success in the clinic. However, one of the major challenges for the development of DNA vaccines is their poor immunogenicity in humans, which has led to refinements in DNA delivery, dosage in prime/boost regimens and the inclusion of adjuvants to enhance their immunogenicity. In this review, we focus on adjuvants that can enhance the immunogenicity of DNA encoded antigens and highlight the development of a novel cytolytic DNA platform encoding a truncated mouse perforin. The application of this innovative DNA technology has considerable potential in the development of effective vaccines.
Title: vaccines Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines

A: True
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Q: Paragraph: Human sera were examined by immuno-blotting for antibodies to the reverse transcriptase of human hepatitis B virus (HBV) believed to be encoded in the P open reading frame (P-ORF). Sera from patients with self-limited (n = 58), acute (n = 23), and chronic (n = 8) hepatitis were analysed. One of the sera with markers of a prior infection and two sera of chronically infected patients reacted with a protein synthesized in E. coli that contains the middle part of the predicted polymerase. Other E. coli fusion proteins containing overlapping or different regions of P-ORF were used to localize antigenic domains. Antibody binding to two different domains representing the middle and the C-terminal region of P-ORF was obtained in the sera of chronically infected patients. Our findings are indirect evidence for the in vivo expression of the complete HBV polymerase reading frame.
Title: Abstracts of Papers Presented at the Session of the Virology Section of the Deutsche Gesellschaft fiir Hygiene und Mikrobiologie

A:
True
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