Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Example Input: Stirring, surface area, and temperature affect the rate at solute dissolves what occurs.
Example Output: Stirring, surface area, and temperature affect the rate at which what occurs?

Example Input: The female reproductive system consists of structures that produce eggs, secrete female sex hormones, and ultimately enable birth of a fetus.
Example Output: What system consists of structures that produce eggs, secrete female sex hormones, and ultimately enable birth of a fetus?

Example Input: Human actions is responsible for the extinction of hundreds of species of birds.
Example Output:
Which single most factor is responsible for the extinction of hundreds of species of birds?