In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.

Ex Input:
Context: Slumped posture is a diagnostic feature of depression. While research shows upright posture improves self-esteem and mood in healthy samples, little research has investigated this in depressed samples. This study aimed to investigate whether changing posture could reduce negative affect and fatigue in people with mild to moderate depression undergoing a stressful task.', 'Sixty-one community participants who screened positive for mild to moderate depression were recruited into a study purportedly on the effects of physiotherapy tape on cognitive function. They were randomized to sit with usual posture or upright posture and physiotherapy tape was applied. Participants completed the Trier Social Stress Test speech task. Changes in affect and fatigue were assessed. The words spoken by the participants during their speeches were analysed.', 'At baseline, all participants had significantly more slumped posture than normative data. The postural manipulation significantly improved posture and increased high arousal positive affect and fatigue compared to usual posture. The upright group spoke significantly more words than the usual posture group, used fewer first person singular personal pronouns, but more sadness words. Upright shoulder angle was associated with lower negative affect and lower anxiety across both groups.\Question: Does upright posture improve affect and fatigue in people with depressive symptoms?

Ex Output:
The experiment was only brief and a non-clinical sample was used.

Ex Input:
Context: Strontium ranelate reduces fracture risk in postmenopausal women with osteoporosis. Evidence from non-clinical studies and analyses of bone markers in phase III trials indicate that this is due to an increase in osteoblast formation and a decrease of osteoclastic resorption. The aim of this work was to investigate, in human cells, the mechanisms by which strontium ranelate is able to influence the activities of osteoblasts and osteoclasts.', 'Human primary osteoblasts were used to examine effects of strontium ranelate on replication (thymidine incorporation), differentiation (Runx2 and alkaline phosphatase) and cell survival (cell counts and caspase activity). Osteoprotegerin (OPG) was measured by quantitative reverse transcription PCR (qRT-PCR) and elisa and receptor activator of NFkappaB ligand (RANKL) by qRT-PCR and Western blot. As strontium ranelate has been proposed as an agonist of the calcium-sensing receptor (CaSR), the involvement of CaSR in the effects of strontium ranelate on OPG and RANKL expression, and cell replication was examined using siRNA.', 'Strontium ranelate increased mRNA and protein levels of OPG and suppressed those of RANKL. Strontium ranelate also stimulated osteoblast replication and differentiation and increased cell survival under stress. Knocking down CaSR suppressed strontium ranelate-induced stimulation of OPG mRNA, reduction of RANKL mRNA, and increase in replication, indicating the involvement of CaSR in these responses.\Question: Do osteoblasts play key roles in the mechanisms of action of strontium ranelate?

Ex Output:
Our results demonstrate that osteoblasts play a key role in the mechanism of action of the anti-fracture agent, strontium ranelate by mediating both its anabolic and anti-resorptive actions, at least in part, via activation of CaSR.

Ex Input:
Context: Most astigmats have a similar level of astigmatism in each eye. However, there is controversy over whether the astigmatic axes in fellow eyes typically show direct or mirror symmetry. We carried out a statistical analysis designed to address this issue.', "The median absolute difference in the astigmatic axes of fellow eyes was calculated for a sample of 50 995 astigmats (subjects with at least 0.25 D of astigmatism in each eye). This was done, firstly, for a 'direct symmetry model' in which the difference in axis was calculated as |AxisR - AxisL| and secondly, for a 'mirror symmetry model' in which the difference in axis was calculated as |AxisR - (180 - AxisL)|.", 'Under the direct symmetry model, the median absolute difference in the axis of astigmatism between fellow eyes was 20 degrees. Under the mirror symmetry model, the median absolute difference in the axis of astigmatism between fellow eyes was significantly lower, at 10 degrees (p < 10e-100). Comparable results were found when the analysis was restricted to subjects with: lower levels of astigmatism (< or =1.00 D), higher levels of astigmatism (>1.00 D), against-the-rule astigmatism, with-the-rule astigmatism or oblique astigmatism (all p < 10e-100).\Question: Do axes of astigmatism in fellow eyes show mirror rather than direct symmetry?

Ex Output:
Our results show that mirror, rather than direct, symmetry is the norm.