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Some of these estimates also take into account the opportunity cost of investing capital many years before revenues are realized (see Time-value of money). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A direct consequence within the pharmaceutical industry value chain is that major pharmaceutical multinationals tend to increasingly outsource risks related to fundamental research, which somewhat reshapes the industry ecosystem with biotechnology companies playing an increasingly important role, and overall strategies being redefined accordingly. Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop.
What happens when companies outsource?
A: somewhat reshapes the industry ecosystem with biotechnology companies

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The first truth explains the nature of dukkha. Dukkha is commonly translated as "suffering", "anxiety", "unsatisfactoriness", "unease", etc., and it is said to have the following three aspects:
Suffering, anxiety, unsatisfactoriness, and unease is the translation of what word?
A: Dukkha

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The Greeks of classical antiquity idealized their Mycenaean ancestors and the Mycenaean period as a glorious era of heroes, closeness of the gods and material wealth. The Homeric Epics (i.e. Iliad and Odyssey) were especially and generally accepted as part of the Greek past and it was not until the 19th century that scholars began to question Homer's historicity. As part of the Mycenaean heritage that survived, the names of the gods and goddesses of Mycenaean Greece (e.g. Zeus, Poseidon and Hades) became major figures of the Olympian Pantheon of later antiquity.
Who was the author of these poems?
A: unanswerable

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In Canada, the term "football" may refer to Canadian football and American football collectively, or to either sport specifically, depending on context. The two sports have shared origins and are closely related but have significant differences. In particular, Canadian football has 12 players on the field per team rather than 11; the field is roughly 10 yards wider, and 10 yards longer between end-zones that are themselves 10 yards deeper; and a team has only three downs to gain 10 yards, which results in less offensive rushing than in the American game. In the Canadian game all players on the defending team, when a down begins, must be at least 1 yard from the line of scrimmage. (The American game has a similar "neutral zone" but it is only the length of the football.)
How far away from the line of scrimmage must Canadian football defenders be?
A:
1 yard