Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: The translocation (9;22) gives rise to the p190(Bcr-Abl) and p210(Bcr-Abl) tyrosine kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive (Ph(+)) acute leukemia patients failing to respond to initial induction therapy have a poor prognosis with few effective treatment options. Imatinib is an orally administered, potent inhibitor of the Bcr-Abl tyrosine kinase. We conducted a clinical trial in 56 patients with relapsed or refractory Ph(+) acute lymphoblastic leukemia (ALL; 48 patients) or chronic myelogenous leukemia in lymphoid blast crisis (LyBC; 8 patients). Imatinib was given once daily at 400 mg or 600 mg. Imatinib induced complete hematologic responses (CHRs) and complete marrow responses (marrow-CRs) in 29% of ALL patients (CHR, 19%; marrow-CR, 10%), which were sustained for at least 4 weeks in 6% of patients. Median estimated time to progression and overall survival for ALL patients were 2.2 and 4.9 months, respectively. CHRs were reported for 3 (38%) of the patients with LyBC (one sustained CHR). Grade 3 or 4 treatment-related nonhematologic toxicity was reported for 9% of patients; none of the patients discontinued therapy because of nonhematologic adverse reactions. Grade 4 neutropenia and thrombocytopenia occurred in 54% and 27% of patients, respectively. Imatinib therapy resulted in a clinically relevant hematologic response rate in relapsed or refractory Ph(+) acute lymphoid leukemia patients, but development of resistance and subsequent disease progression were rapid. Further studies are warranted to test the effects of imatinib in combination with other agents and to define the mechanisms of resistance to imatinib.
[A]: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

[Q]: Microscopes, tools that you may get to use in your class, are some of the most important tools in biology ( Figure Microscopy is the study of small objects using microscopes. Look at your fingertips. Before microscopes were invented in 1595, the smallest things you could see on yourself were the tiny lines in your skin. But what else is hidden in your skin? Over four hundred years ago, two Dutch spectacle makers, Zaccharias Janssen and his son Hans, were experimenting with several lenses in a tube. They discovered that nearby objects appeared greatly enlarged, or magnified. This was the forerunner of the compound microscope and of the telescope. In 1665, Robert Hooke, an English natural scientist, used a microscope to zoom in on a piece of cork - the stuff that makes up the stoppers in wine bottles, which is made from tree bark. Inside of cork, he discovered tiny structures, which he called cells. It turns out that cells are the smallest structural unit of living organisms. This finding eventually led to the development of the theory that all living things are made of cells. Without microscopes, this discovery would not have been possible, and the cell theory would not have been developed. Hookes discovery of the cell set the stage for other scientists to discover other types of organisms. After Hooke, the "father of microscopy," Dutch scientist Antoine van Leeuwenhoek ( Figure 1.2) taught himself to make one of the first microscopes. In one of his early experiments, van Leeuwenhoek took a sample of scum from his own teeth and used his microscope to discover bacteria, the smallest living organism on the planet. Using microscopes, van Leeuwenhoek also discovered one-celled protists and sperm cells. Today, microscopes are used by all types of scientists, including cell biologists, microbiologists, virologists, forensic scientists, entomologists, taxonomists, and many other types. Antoine van Leeuwenhoek, a Dutch cloth merchant with a passion for microscopy. Some modern microscopes use light, as Hookes and van Leeuwenhoeks did. Others may use electron beams or sound waves. Researchers now use these four types of microscopes: 1. Light microscopes allow biologists to see small details of a specimen. Most of the microscopes used in schools and laboratories are light microscopes. Light microscopes use lenses, typically made of glass or plastic, to focus light either into the eye, a camera, or some other light detector. The most powerful light microscopes can make images up to 2,000 times larger. 2. Transmission electron microscopes (TEM) focus a beam of electrons through an object and can make an image up to two million times bigger, with a very clear image. 3. Scanning electron microscopes (SEM) allow scientists to find the shape and surface texture of extremely small objects, including a paperclip, a bedbug, or even an atom. These microscopes slide a beam of electrons across the surface of a specimen, producing detailed maps of the surface of objects. Magnification in a SEM can be controlled over a range from about 10 to 500,000 times. 4. Scanning acoustic microscopes use sound waves to scan a specimen. These microscopes are useful in biology and medical research. Scanning Electron Microscope at (5:04) Click image to the left or use the URL below. URL: 1. How is the electron beam focused? 2. What part of a specimen does a scanning electron microscope look at? 3. Why is it important that a specimen for an electron microscope be placed in a vacuum? Why is this step unnecessary for a light microscope?
[A]: who discovered single-celled protists?

[Q]: Children who see their parents drunk are twice likely to get drunk themselves, a survey of young teenagers has suggested. Poor parental supervision also raises the chances of teenage drinking, said the Joesph Rowntree Foundation. If parents don't know where their children are on a Saturday night, or let them watch films of violence, they are more likely to have had an alcoholic drink. The survey also found the behavior of friends is also a powerful factor in drinking habits. The more time teenagers spend with friends, the more likely they are to drink alcohol. In this survey of 5,700 children aged 13 to 16, carried out by the Joseph Rowntree Foundation, researchers found that one in five wanted to have a drink by the time they were 14. By the age of 16, half of those questioned said they had been drunk. Pamela Bremner, scientist of the survey, said, "For the first time in the UK, this study shows what most influences young people's drinking behavior." "It found that the behavior of friends and family is the most common influential factor in determining how likely and how often a young person will drink alcohol." Don Shenker, Chief Executive of Alcohol Concern, said, "Government ministers must also look at some of the causes of why it is so easy for children to get alcohol, usually from the home." "Governments should look to see if they've done everything they can to help the large supermarkets from continuing to sell cheap alcohol which encourages more alcohol sales and therefore results in more alcohol being stored in the home." The Royal College of Physicians also said it was not surprising that being able to get alcohol easily was an important factor on current drinking problems and drunkenness of teenagers. A statement said, "This shows that the government needs to focus more attention on increasing the price of alcohol, and increasing education and national campaigns for both young people and their families on the dangers of alcohol."
[A]:
Who should be responsible for the fact that some teenagers formed the habit of drinking besides their parents and friends, according to Don Shenker?