Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Example Input: Context: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Despite significant progresses in the last decades, the origin of this cancer remains unclear and no efficient therapy exists. PDAC does not arise de novo: three remarkable different types of pancreatic lesions can evolve towards pancreatic cancer. These precursor lesions include: Pancreatic intraepithelial neoplasia (PanIN) that are microscopic lesions of the pancreas, Intraductal Papillary Mucinous Neoplasms (IPMN) and Mucinous Cystic Neoplasms (MCN) that are both macroscopic lesions. However, the cellular origin of these lesions is still a matter of debate. Classically, neoplasm initiation or progression is driven by several genetic and epigenetic alterations. The aim of this review is to assemble the current information on genetic mutations and epigenetic disorders that affect genes during pancreatic carcinogenesis. We will further discuss the interest of the genetic and epigenetic alterations for the diagnosis and prognosis of PDAC. Large genetic alterations (chromosomal deletion/amplification) and single point mutations are well described for carcinogenesis inducers. Mutations classically occur within key regions of the genome. Consequences are various and include activation of mitogenic pathways or silencing of apoptotic processes. Alterations of K-RAS, P16 and DPC4 genes are frequently observed in PDAC samples and have been described to arise gradually during carcinogenesis. DNA methylation is an epigenetic process involved in imprinting and X chromosome inactivation. Alteration of DNA methylation patterns leads to deregulation of gene expression, in the absence of mutation. Both genetic and epigenetic events influence genes and non-coding RNA expression, with dramatic effects on proliferation, survival and invasion. Besides improvement in our fundamental understanding of PDAC development, highlighting the molecular alterations that occur in pancreatic carcinogenesis could provide new clinical tools for early diagnosis of PDAC and the molecular basis for the development of new effective therapies.
Question: Which is the molecular mechanism underlying K-ras alterations in carcinomas?
Example Output: point mutations

Example Input: Context: Many people have problems with their vision, or ability to see. Often, the problem is due to the shape of the eyes and how they focus light. Two of the most common vision problems are nearsightedness and farsightedness, which you can read about below. You may even have one of these vision problems yourself. Usually, the problems can be corrected with contact lenses or lenses in eyeglasses. In many people, they can also be corrected with laser surgery, which reshapes the outer layer of the eye. Click image to the left or use the URL below. URL: Nearsightedness, or myopia, is the condition in which nearby objects are seen clearly, but distant objects appear blurry. The Figure 1.1 shows how it occurs. The eyeball is longer (from front to back) than normal. This causes images to be focused in front of the retina instead of on the retina. Myopia can be corrected with concave lenses. The lenses focus images farther back in the eye, so they fall on the retina instead of in front of it. Q: Sometimes squinting the eyes can help someone see more clearly. Why do you think this works? A: Squinting may improve focus by slightly changing the shape of the eyes. When you squint, you tighten muscles around the eyes, putting pressure on the eyeballs. Farsightedness, or hyperopia, is the condition in which distant objects are seen clearly, but nearby objects appear blurry. It occurs when the eyeball is shorter than normal (see Figure 1.2). This causes images to be focused in a spot that would fall behind the retina (if light could pass through the retina). Hyperopia can be corrected with convex lenses. The lenses focus images farther forward in the eye, so they fall on the retina instead of behind it. Q: Joey has hyperopia. When is he more likely to need his glasses: when he reads a book or when he watches TV? A: With hyperopia, Joey is farsighted. He can probably see the TV more clearly than the words in a book because the TV is farther away. Therefore, he is more likely to need his glasses when he reads than when he watches TV.
Question: in hyperopia, the eyeball is
Example Output: shorter than normal.

Example Input: Context: DNA damage is preferentially repaired in the transcribed strand of many active genes. Although the concept of DNA repair coupled with transcription has been widely accepted, its mechanisms remain elusive. We recently reported that in Chinese hamster ovary cells while ultraviolet light-induced cyclobutane pyrimidine dimers (CPDs) are preferentially repaired in the transcribed strand of dihydrofolate reductase gene, CPDs are efficiently repaired in both strands of adenine phosphoribosyltransferase (APRT) locus, in either a transcribed or nontranscribed APRT gene (1). These results suggested that the transcription dependence of repair may depend on genomic context. To test this hypothesis, we constructed transfectant cell lines containing a single, actively transcribed APRT gene, integrated at different genomic sites. Mapping of CPD repair in the integrated APRT genes in three transfectant cell lines revealed two distinct repair patterns, either preferential repair of CPDs in the transcribed strand or very poor repair in both strands. Similar kinetics of micrococcal nuclease digestion were seen for all three transfectant APRT gene domains and endogenous APRT locus. Our results suggest that both the efficiency and strand-specificity of repair of an actively transcribed gene are profoundly affected by genomic context but do not reflect changes in first order nucleosomal structure.
Question: Which gene strand is targeted by transcription-coupled repair (TCR)?
Example Output:
the transcribed strand