Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Question: Does estrogen receptor beta influence ischemic tolerance in the aged female rat heart?
Answer: Here, for the first time, our data suggest that acute ER activation does not impact ischemic tolerance in the adult or aged female Fischer 344 rat myocardium and this likely due to a lack of detectable ER.
no