Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Chronic myeloid leukemia (CML) is a progressive and often fatal myeloproliferative neoplasm. The hallmark of CML is an acquired chromosomal translocation known as the Philadelphia chromosome (Ph), which results in the synthesis of the breakpoint cluster region-Abelson murine leukemia (BCR-ABL) fusion oncoprotein, a constitutively active tyrosine kinase. The introduction of imatinib, a tyrosine kinase inhibitor (TKI) that is specific for BCR-ABL, was a major breakthrough in CML therapy. Although most patients respond to first-line imatinib therapy, some experience loss of response (resistance) or require treatment discontinuation because of toxicity (intolerance). For patients with CML, failure on standard-dose imatinib therapy (400 mg daily), imatinib dose escalation (600-800 mg daily) is a second-line option. However, high-dose imatinib is not an appropriate approach for patients who experience drug toxicity, and there remain questions over the durability of responses achieved with this strategy. Alternative second-line options include the TKIs dasatinib and nilotinib. A substantial amount of long-term data for these agents is available. Although both are potent and specific BCR-ABL TKIs, dasatinib and nilotinib exhibit unique pharmacologic profiles and response patterns relative to different patient characteristics, such as disease stage and BCR-ABL mutation status. To optimize therapeutic benefit, clinicians should select treatment based on each patient's historic response, adverse-event tolerance, and risk factors.
[EX A]: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

[EX Q]: To be a good aquifer, the rock in the aquifer must have good: porosity: small spaces between grains permeability: connections between pores To reach an aquifer, surface water infiltrates downward into the ground through tiny spaces or pores in the rock. The water travels down through the permeable rock until it reaches a layer that does not have pores; this rock is impermeable (Figure 1.1). This impermeable rock layer forms the base of the aquifer. The upper surface where the groundwater reaches is the water table. Groundwater is found beneath the solid surface. Notice that the water table roughly mirrors the slope of the lands surface. A well penetrates the water table. For a groundwater aquifer to contain the same amount of water, the amount of recharge must equal the amount of discharge. What are the likely sources of recharge? What are the likely sources of discharge? What happens to the water table when there is a lot of rainfall? What happens when there is a drought? Although groundwater levels do not rise and fall as rapidly as at the surface, over time the water table will rise during wet periods and fall during droughts. In wet regions, streams are fed by groundwater; the surface of the stream is the top of the water table (Figure 1.2). In dry regions, water seeps down from the stream into the aquifer. These streams are often dry much of the year. Water leaves a groundwater reservoir in streams or springs. People take water from aquifers, too. Groundwater meets the surface in a stream (Figure 1.2) or a spring (Figure 1.3). A spring may be constant, or may only flow at certain times of year. Towns in many locations depend on water from springs. Springs can be an extremely important source of water in locations where surface water is scarce. A well is created by digging or drilling to reach groundwater. It is important for anyone who intends to dig a well to know how deep beneath the surface the water table is. When the water table is close to the surface, wells are a convenient method for extracting water. When the water table is far below the surface, specialized equipment must The top of the stream is the top of the water table. The stream feeds the aquifer. A spring in Croatia bubbles to the surface and feeds the river Cetina. be used to dig a well. Most wells use motorized pumps to bring water to the surface, but some still require people to use a bucket to draw water up (Figure 1.4). An old-fashioned well that uses a bucket drawn up by hand.
[EX A]: the surface of a stream is

[EX Q]: Different rock types weather at different rates. Certain types of rock are very resistant to weathering. Igneous rocks, especially intrusive igneous rocks such as granite, weather slowly because it is hard for water to penetrate them. Other types of rock, such as limestone, are easily weathered because they dissolve in weak acids. Rocks that resist weathering remain at the surface and form ridges or hills. Shiprock in New Mexico is the throat of a volcano thats left after the rest of the volcano eroded away. The rock thats left behind is magma that cooled relatively slowly and is harder than the rock that had surrounded it. Different minerals also weather at different rates. Some minerals in a rock might completely dissolve in water, but the more resistant minerals remain. In this case, the rocks surface becomes pitted and rough. When a less resistant mineral dissolves, more resistant mineral grains are released from the rock. A beautiful example of this effect is the "Stone Forest" in China, see the video below: The Shiprock formation in northwest New Mexico is the central plug of resistant lava from which the surrounding rock weath- ered and eroded away. Click image to the left or use the URL below. URL: A regions climate strongly influences weathering. Climate is determined by the temperature of a region plus the amount of precipitation it receives. Climate is weather averaged over a long period of time. Chemical weathering increases as: Temperature increases: Chemical reactions proceed more rapidly at higher temperatures. For each 10o C increase in average temperature, the rate of chemical reactions doubles. Precipitation increases: More water allows more chemical reactions. Since water participates in both mechan- ical and chemical weathering, more water strongly increases weathering. So how do different climates influence weathering? A cold, dry climate will produce the lowest rate of weathering. A warm, wet climate will produce the highest rate of weathering. The warmer a climate is, the more types of vegetation it will have and the greater the rate of biological weathering (Figure 1.2). This happens because plants and bacteria grow and multiply faster in warmer temperatures. Some resources are concentrated by weathering processes. In tropical climates, intense chemical weathering carries away all soluble minerals, leaving behind just the least soluble components. The aluminum oxide, bauxite, forms this way and is our main source of aluminum ore.
[EX A]:
climate is determined by