Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: ZFHX1B encodes Smad-interacting protein 1, a transcriptional corepressor involved in the transforming growth factors beta (TGFbeta) signaling pathway. ZFHX1B mutations cause a complex developmental phenotype characterized by severe mental retardation (MR) and multiple congenital defects. We compared the distribution of ZFHX1B transcripts during mouse and human embryogenesis as well as in adult mice and humans. This showed that this gene is strongly transcribed at an early stage in the developing peripheral and central nervous systems of both mice and humans, in all neuronal regions of the brains of 25-week human fetuses and adult mice, and at varying levels in numerous nonneural tissues. Northern blot analysis suggested that ZFHX1B undergoes tissue-specific alternative splicing in both species. These results strongly suggest that ZFHX1B determines the transcriptional levels of target genes in various tissues through the combinatorial interactions of its isoforms with different Smad proteins. Thus, as well as causing neural defects, ZFHX1B mutations may also cause other malformations.

Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?

Input: Consider Input: MPEG-4 Part 14 is an instance of the more general ISO/IEC 14496-12:2004 (MPEG-4 Part 12: ISO base media file format) which is directly based upon the QuickTime File Format.

Output: Which is the basis of MPEG-4 Part 14?

Input: Consider Input: It wasnt always known that fossils were parts of living organisms. In 1666, a young doctor named Nicholas Steno dissected the head of an enormous great white shark that had been caught by fisherman near Florence, Italy. Steno was struck by the resemblance of the sharks teeth to fossils found in inland mountains and hills (Figure 1.1). Most people at the time did not believe that fossils were once part of living creatures. Authors in that day thought that the fossils of marine animals found in tall mountains, miles from any ocean could be explained in one of two ways: The shells were washed up during the Biblical flood. (This explanation could not account for the fact that fossils were not only found on mountains, but also within mountains, in rocks that had been quarried from deep below Earths surface.) The fossils formed within the rocks as a result of mysterious forces. But for Steno, the close resemblance between fossils and modern organisms was impossible to ignore. Instead of invoking supernatural forces, Steno concluded that fossils were once parts of living creatures. Fossil Shark Tooth (left) and Modern Shark Tooth (right). A fossil is any remains or traces of an ancient organism. Fossils include body fossils, left behind when the soft parts have decayed away, and trace fossils, such as burrows, tracks, or fossilized coprolites (feces). Collections of fossils are known as fossil assemblages. Click image to the left or use the URL below. URL: Becoming a fossil isnt easy. Only a tiny percentage of the organisms that have ever lived become fossils. Why do you think only a tiny percentage of living organisms become fossils after death? Think about an antelope that dies on the African plain (Figure 1.2). Most of its body is eaten by hyenas and other scavengers and the remaining flesh is devoured by insects and bacteria. Only bones are left behind. As the years go by, the bones are scattered and fragmented into small pieces, eventually turning into dust. The remaining nutrients return to the soil. This antelope will not be preserved as a fossil. Is it more likely that a marine organism will become a fossil? When clams, oysters, and other shellfish die, the soft parts quickly decay, and the shells are scattered. In shallow water, wave action grinds them into sand-sized pieces. The shells are also attacked by worms, sponges, and other animals (Figure 1.3). How about a soft bodied organism? Will a creature without hard shells or bones become a fossil? There is virtually no fossil record of soft bodied organisms such as jellyfish, worms, or slugs. Insects, which are by far the most common land animals, are only rarely found as fossils (Figure 1.4). Despite these problems, there is a rich fossil record. How does an organism become fossilized? A rare insect fossil. Usually its only the hard parts that are fossilized. The fossil record consists almost entirely of the shells, bones, or other hard parts of animals. Mammal teeth are much more resistant than other bones, so a large portion of the mammal fossil record consists of teeth. The shells of marine creatures are common also. Quick burial is essential because most decay and fragmentation occurs at the surface. Marine animals that die near a river delta may be rapidly buried by river sediments. A storm at sea may shift sediment on the ocean floor, covering a body and helping to preserve its skeletal remains (Figure 1.5). This fish was quickly buried in sediment to become a fossil. Quick burial is rare on land, so fossils of land animals and plants are less common than marine fossils. Land People buried by the extremely hot eruption of ash and gases at Mt. Vesuvius in 79 AD. Unusual circumstances may lead to the preservation of a variety of fossils, as at the La Brea Tar Pits in Los Angeles, California. Although the animals trapped in the La Brea Tar Pits probably suffered a slow, miserable death, their bones were preserved perfectly by the sticky tar. (Figure 1.7). Artists concept of animals surrounding the La Brea Tar Pits.
Output: a ______ fossil is left behind when the soft parts have decayed away.