Detailed Instructions: Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Q: Context: Neuromuscular blocking agents (NMBAs) bind the nicotinic acetylcholine receptor 1 (nAChR1) that also contributes to inflammatory signaling. Thus, the author hypothesized that the use of NMBA mitigates lung injury by improving ventilator synchrony and decreasing inflammatory responses.', 'Lung injury was induced by intratracheal instillation of hydrogen chloride in rats that were randomized to receive no NMBA with evidence of asynchronous ventilation (noNMBA/aSYNC, n = 10); no NMBA with synchronous ventilation (noNMBA/SYNC, n = 10); cisatracurium (CIS, n = 10); or pancuronium (PAN, n = 10). Mechanical ventilation was set at a tidal volume of 6 ml/kg and positive end-expiratory pressure 8 cm H2O for 3 h. Human lung epithelial, endothelial, and CD14 cells were challenged with mechanical stretch, lipopolysaccharide, lung lavage fluids (bronchoalveolar lavage fluid), or plasma obtained from patients (n = 5) with acute respiratory distress syndrome, in the presence or absence of CIS or small-interfering RNA and small hairpin RNA to attenuate the cell expression of nAChR1.', 'The use of CIS and PAN improved respiratory compliance (7.2 0.7 in noNMBA/aSYNC, 6.6 0.5 in noNMBA/SYNC, 5.9 0.3 in CIS, and 5.8 0.4 cm H2O/l in PAN; P < 0.05), increased PaO2 (140 54, 209 46, 269 31, and 269 54 mmHg, respectively, P < 0.05), and decreased the plasma levels of tumor necrosis factor- (509 252 in noNMBA, 200 74 in CIS, and 175 84 pg/ml in PAN; P < 0.05) and interleukin-6 (5789 79, 1608 534, and 2290 315 pg/ml, respectively; P < 0.05). The use of CIS and PAN or silencing the receptor nAChR1 resulted in decreased cytokine release in the human cells in response to a variety of stimuli mentioned earlier.
Answer: The use of NMBA is lung protective through its antiinflammatory properties by blocking the nAChR1.
A:
Does neuromuscular Blocking Agent Cisatracurium attenuate Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-1?