In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: As the lung is a portal between the ambient environment and the internal milieu, it is the most frequent site of serious infections. A number of factors predispose to pulmonary infection, and these include distortions in lung anatomy, decreased mucociliary clearance, as well as abnormal cellular and humoral immune responses. The optimal treatment of infection requires diagnosing its cause. As a large variety of microbes can infect the lung, and as the histopathology of noninfectious conditions frequently mimics infection, the differential diagnosis of pulmonary infection is often broad. While in many cases, the clinical history, radiographic findings, and the noninvasive sampling of secretions can establish the cause of infection, at times, a lung biopsy will be required.
Title: Pulmonary Infection
Example Output: False

Example Input: Paragraph: Infectious bronchitis (IB) generated by the infectious bronchitis virus (IBV) causes economic difficulties for livestock farmers. The 3D8 single chain variable fragment (scFv) protein is a recombinant antibody with nuclease activity that shows antiviral effects against various DNA and RNA viruses in mice and chickens. In this experiment, 3D8 scFv G 2 transgenic chickens produced by crossing 3D8 scFv G 1 transgenic rooster and wild type hens were screened by genomic PCR and immunohistochemistry analysis. 3D8 scFv transgenic chickens, wild type sibling chickens, and SPF chickens were directly infected with IBV (5 chickens per group) and indirectly infected by airborne propagation (15 chickens per group). The relative IBV shedding titers were measured by quantitative real-time PCR using oropharyngeal and cloacal swabs on days 3 and 5 after intraocular infection. The viral load was significantly decreased in the 3D8 scFv transgenic chickens from the contact transmission group. Additionally, blood was collected from each group on day 17 post-infection. The ELISA results showed a marked reduction of the antibody titer against IBV in the 3D8 scFv transgenic chickens from the contact transmission group. These results suggest that the 3D8 scFv protein potentially inhibits infectious bronchitis virus transmission in chickens.
Title: The 3D8 single chain variable fragment protein suppress infectious bronchitis virus transmission in the transgenic chickens
Example Output: True

Example Input: Paragraph: Ebolaviruses are non-segmented, negative-sense RNA viruses (NNSVs) within the order 19 Mononegavirales that possess the multifunctional virion protein 35 (VP35), a major determinant 20 of virulence and pathogenesis that is indispensable for viral replication and host innate immune 21 evasion. VP35 is functionally equivalent to the phosphoprotein (P) of other mononegaviruses 22 such as rhabdoviruses and paramyxoviruses. Phosphorylation of the P protein is universally 23 regarded as functionally important however, a regulatory role(s) of phosphorylation on VP35 24 function remains unexplored. Here, we identified a highly conserved Ser129 residue near the 25 homo-oligomerization coiled coil motif, which is essential for VP35 functions. Affinity-purification 26 MS followed by post-translational modification (PTM) analysis predicted phosphorylation of 27 Ser129. Co-immunoprecipitation, cross-linking, and biochemical characterization studies 28 revealed a moderately decreased capacity of VP35-S129A to oligomerize. Functional analysis 29 showed that Ser-to-Ala substitution of Ebola virus (EBOV) VP35 did not affect IFN inhibitory 30 activity but nearly abolished EBOV minigenome activity. Further coimmunoprecipitation studies 31 demonstrated a lost interaction between VP35-S129A and the amino terminus of the viral 32 polymerase but not between viral nucleoprotein (NP) or VP35-WT. Taken together, our findings 33 provide evidence that phosphorylation modulates VP35 function, supporting VP35 as a NNSV P 34 protein and providing a potentially valuable therapeutic target. 35 Importance 36 Ebola virus (EBOV) can cause severe disease in humans. The 2013-2016 West African 37 epidemic and the two recent outbreaks in the Democratic Republic of the Congo underscore the 38 urgent need for effective countermeasures, which remain lacking. A better understanding of 39 EBOV biology and the modulation of multifunctional viral proteins is desperately needed to 40 develop improved therapeutics. We provide evidence here that function of virion protein 35 41 (VP35) is modulated by phosphorylation of Ser129, a conserved residue among other 42 ebolavirus species. These findings shed light on EBOV biology and present a potential target for 43 broad acting anti-ebolavirus therapeutics. 44 45 46 47 48 49
Title: Mutation of Ebola virus VP35 Ser129 uncouples interferon antagonist and replication functions
Example Output:
True