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All spontaneous chemical reactions, if coupled to no other source of energy, are exergonic. On the other hand, if some other free energy source is coupled to the reaction, the reaction can be driven "beyond equilibrium" by using some of the energy source.
Output:
All chemical reactions, if coupled to no other source of energy, are exergonic. If energy source is coupled, the reaction can be driven "beyond equilibrium" by using the energy source.