In empirical therapy, a patient has proven or suspected infection, but the responsible microorganism is not yet unidentified. While the microorgainsim is being identified the doctor will usually administer the best choice of antibiotic that will be most active against the likely cause of infection usually a broad spectrum antibiotic. Empirical therapy is usually initiated before the doctor knows the exact identification of microorgansim causing the infection as the identification process make take several days in the laboratory.
At what stage does a doctor begin empirical therapy?
While the microorgainsim is being identified

Input: Atlantic City, New Jersey
The 1920s, with tourism at its peak, are considered by many historians as Atlantic City's golden age. During Prohibition, which was enacted nationally in 1919 and lasted until 1933, much liquor was consumed and gambling regularly took place in the back rooms of nightclubs and restaurants. It was during Prohibition that racketeer and political boss Enoch L. "Nucky" Johnson rose to power. Prohibition was largely unenforced in Atlantic City, and, because alcohol that had been smuggled into the city with the acquiescence of local officials could be readily obtained at restaurants and other establishments, the resort's popularity grew further. The city then dubbed itself as "The World's Playground". Nucky Johnson's income, which reached as much as $500,000 annually, came from the kickbacks he took on illegal liquor, gambling and prostitution operating in the city, as well as from kickbacks on construction projects.

During Prohibition how high was Nucky Johnson's income?
Output: as much as $500,000 annually

Input: Article: The Elizabethan navigator, Sir Francis Drake was born in the nearby town of Tavistock and was the mayor of Plymouth. He was the first Englishman to circumnavigate the world and was known by the Spanish as El Draco meaning "The Dragon" after he raided many of their ships. He died of dysentery in 1596 off the coast of Puerto Rico. In 2002 a mission to recover his body and bring it to Plymouth was allowed by the Ministry of Defence. His cousin and contemporary John Hawkins was a Plymouth man. Painter Sir Joshua Reynolds, founder and first president of the Royal Academy was born and educated in nearby Plympton, now part of Plymouth. William Cookworthy born in Kingsbridge set up his successful porcelain business in the city and was a close friend of John Smeaton designer of the Eddystone Lighthouse. On 26 January 1786, Benjamin Robert Haydon, an English painter who specialised in grand historical pictures, was born here. The naturalist Dr William Elford Leach FRS, who did much to pave the way in Britain for Charles Darwin, was born at Hoe Gate in 1791.

Now answer this question: What did the Spanish nickname Sir Francis Drake?

Output: El Draco

Article: Since the 19th century, many if not all presidents were assisted by a central figure or "gatekeeper", sometimes described as the President's Private Secretary, sometimes with no official title at all. Eisenhower formalized this role, introducing the office of White House Chief of Staff an idea he borrowed from the United States Army. Every president after Lyndon Johnson has also appointed staff to this position. Initially, Gerald Ford and Jimmy Carter tried to operate without a chief of staff, but each eventually appointed one.

Question: Who was the last president not to appoint a Chief of Staff?
Ans: Lyndon Johnson

Here is a question about this article: The phenomenon known as "passing as white" is difficult to explain in other countries or to foreign students. Typical questions are: "Shouldn't Americans say that a person who is passing as white is white, or nearly all white, and has previously been passing as black?" or "To be consistent, shouldn't you say that someone who is one-eighth white is passing as black?" ... A person who is one-fourth or less American Indian or Korean or Filipino is not regarded as passing if he or she intermarries with and joins fully the life of the dominant community, so the minority ancestry need not be hidden. ... It is often suggested that the key reason for this is that the physical differences between these other groups and whites are less pronounced than the physical differences between African blacks and whites, and therefore are less threatening to whites. ... [W]hen ancestry in one of these racial minority groups does not exceed one-fourth, a person is not defined solely as a member of that group.
What is the answer to this question: Who are consdered to have the most physical differences?
****
So... African blacks and whites

Article: Madonna's initial music videos reflected her American and Hispanic mixed street style combined with a flamboyant glamor. She was able to transmit her avant-garde downtown New York fashion sense to the American audience. The imagery and incorporation of Hispanic culture and Catholic symbolism continued with the music videos from the True Blue era. Author Douglas Kellner noted, "such 'multiculturalism' and her culturally transgressive moves turned out to be highly successful moves that endeared her to large and varied youth audiences." Madonna's Spanish look in the videos became the fashion trend of that time, in the form of boleros and layered skirts, accessorizing with rosary beads and a crucifix as in the video of "La Isla Bonita".

Question: She transmit her avant garde style to which audience?
Ans:
American audience