In this task, you're given an article and an answer. Your task is to generate the fill-in-the-blank question for this answer based on the given article. The blanks are always at the end of the question, and can be filled with more than one word or phrase.

Q: Article: Modern man has cleared the forests for farmland and for wood, and has also carelessly burned them. More than that, though, he has also interfered with the invisible bonds between the living things in the forests. There are many examples of this kind of destruction. The harmfulness of man's interference can be seen in what happened many years ago in the forest of the Kaibab plateau of northern Arizona. Man tried to improve on the natural web of forest life and destroyed it instead. The Kaibab had a storybook forest of large sized pine, Douglas fir, white fir, blue and _ . In 1882 a visitor noted, "We, who ... have wandered through its forests and parks, have come to regard it as the most enchanting region it has ever been our privilege to visit." This was also the living place of the Rocky Mountain mule deer. Indians hunted there every autumn to gather meat and skins. The forest also had mountain lions, timber wolves and bobcats that kept the deer from multiplying too rapidly. Then, in 1906, President Theodore Roosevelt made the Kaibab a national game preserve. Deer hunting was forbidden. Government hunters started killing off the deer's enemies. In 25 years' time, 6,250 mountain lions, wolves and bobcats were killed. Before the program, there were about 4,000 deer in the Kaibab, by 1924, there were about 100,000. The deer ate every leaf and twig they could reach. But there was not nearly enough food. Hunting of deer was permitted again. This caused a slight decrease in the deer herd ,but a far greater loss resulted from starvation and disease. Some 60 percent of the deer herd died in two winters. By 1930 the herd had dropped to 20,000 animals. By 1942 it was down to 8,000.
Answer: interfering with natural cycle of forest life

A: The destruction of the environment of the Kaibab resulted from _
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Q: Article: There was once a farmer who lived near a road. It was not a busy road,but from time to time,cars passed the farm. Near the farm gate, there was a large hole in the road. this hole was always full of water, and the drivers of the cars could not see how deep the hole was. They thought it was probably not deep.So when they drove into the hole, they could not drive out because it was so deep. The farmer did not spend much time working on his farm. He spent most time watching the hole. Whenever a car drove into it, he would pull the car out with his tractor and he would charge the drivers for much more money than they had expected. One day, a driver of a car said to him, "You must have made a lot of money pulling cars out of this hole night and day." "Oh no," the farmer said, "I don't pull cars out of the hole at night. At night I fill the hole with water."
Answer: liked very much driving through water

A: Many cars went into the hole because the drivers _ .
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Q: Article: Researchers Jose Cordova and Erich Astudillo have discovered a new molecule that kills the bacteria Streptococcus Mutans, long known to be responsible for breaking down sugars in food in the mouth, which damages tooth leading to decay . The new molecule they call "Keep 32" has been found to kill the bacteria. The two have applied for a patent on their discovery and have also begun a marketing strategy aimed at both oral care products and food products. They say either product, if left in the mouth for just 60 seconds ,will kill all the harmful bacteria in the mouth and keep _ at bay for several hours. If the new molecule passes health and safety tests, the two believe products using their new molecule should be on the market in as little as a year and a half. They expect the market for such a product to reach $300 million in just the first year. The two have been working together since 2005 using money from the Founder Institute and say the aim is to approve the process for creating the molecule they've discovered for big companies like Procter & Gamble, Colgate even candy companies such as Hershey's. In interviews, Astudillo has suggested that the two researchers are already heavily into discussion with several companies, some of which are interested in buying the patent once it is approved. Over the years many products have _ with announcement of reducing tooth decay and even the loss of teeth, but other than the introduction of fluoride into drinking water, not much progress has been made. If the announcement made by this new team proves true however, it could foresee a mark in saving the world of tooth decay as well as helping to improve the health for millions of people as tooth decay has been linked to many other health problems throughout the body including heart attacks.
Answer: arrived

A:
The phrase "come on the scene" in Para. 4 is closest in meaning to _ .
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