Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
--------
Question: Munich sincerely invites you to join the 2016 0ktoberfest--the biggest celebration of its kind in Europe. Drink beer by the liter, eat traditional Bavarian food, listen to traditional Bavarian music as well as more up-to-date music, and enjoy yourself with hundreds of other people from all over the world, dancing and singing the hours away. Oktoberfest 2016 begins on Saturday 17th September and runs through to Monday 3rd October 2016. Don't miss the events during Oktoberfest! Grand entry of the Oktoberfest landlords and breweries Date: Saturday, 17th September 2016 Duration: about 45 minutes This is the official prelude to the opening of the Oktoberfest and involves about 1,000 participants, including the landlords' families in decorated carriages, the magnificent horse-drawn drays, waitresses on decorated floats and all the beer tent bands. Oktoberfest Costume and Riflemen-s Parade Date: Sunday, 18th September 2016 Duration:2-2 1/2 hours, about 8000 performers,7 km distance A varied succession of regional costume groups, "troops" in historical uniforms, marching bands, riflemen, thoroughbred horses, oxen, cows, goats, floats displaying typical local traditions and historic carriages all pass by in a 7-kilometer-long procession through the streets of the city center. Open-Air Oktoberfest Music Date: Sunday, 25th September 2016 Place: on the steps of the Bavaria statue At the traditional open-air concert on the second Sunday of the Oktoberfest, all the instruments that make up typical Bavarian wind band music can be heard. The bands from all of the tents come together at the steps under the Bavaria statue to play the most well-known songs and marches of Oktoberfest together while being conducted by distinguished Munich personalities.

Answer: When will visitors see costume soldiers marching on the street?

Question: Many patients with restless legs syndrome (Willis-Ekbom disease) complain of burning sensations in their feet associated with the desire to move, such that they seek cooler environments. This pilot study aimed to characterise the microvascular skin changes in 12 patients with restless legs syndrome compared with 12 age- and sex-matched controls. Patients with moderate or severe restless legs syndrome and controls underwent detailed thermovascular assessment in a controlled temperature room at three different stages (normothermic phase 23C, hot phase 30C, cold phase 18C). Microvascular activity was recorded during all phases by bilateral great toe laser-Doppler flowmetry and also by whole-body thermography. Patient and control measurements were compared. The study protocol was well tolerated. Parameters extracted from the laser-Doppler flowmetry measurements were used to model a logistic function using binary logistic regression. This demonstrated a statistically significant difference between patients with restless legs syndrome and healthy controls (P<0.001). Visual inspection of the body thermography image sequences showed increased lower limb movement in patients with restless legs syndrome patients compared with controls. Thermography analysis also showed significant differences between foot temperatures in patients with restless legs syndrome compared with controls during the hot phase (P=0.011). Notably, patients with restless legs syndrome had more uniform foot temperatures, whereas controls had a wider variability in surface temperature across the feet. This novel study demonstrates impaired microvascular circulation in patients with restless legs syndrome in comparison to matched controls and a potential mechanism for the sensation of burning feet. The protocol also provides an experimental paradigm to test therapeutic interventions for the future.

Answer: Willis-Ekbom disease is also known as?

Question: A significant role for IFN in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFN monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more significant clinical manifestations. At the same time, evidence supports an anti-inflammatory and beneficial role of IFN locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFN. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease - particularly at local sites of inflammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quantification of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents.

Answer:
Which is the most common gene signature in Rheumatoid Arthritis patients?