Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Q: Context: Long-term prognosis of hepatocellular carcinoma (HCC) patients is challenging, and novel biomarkers are needed to predict patient risk and serve as potential therapeutic target.', 'We found -glucosidase 1 is significantly overexpressed and activated in primary HCC tissue and multiple HCC cell lines. -Glucosidase 1 expression is associated with predicting prognosis of HCC patients under chemotherapy. Silencing -glucosidase 1 inhibits growth and survival of HCC cells, with preferential inhibitory effects on high -glucosidase 1-expressing cells. Combination of chemo drug with -glucosidase 1 inhibitor sensitized HCC cells to chemotherapy.
Answer: Our data support -glucosidase 1 as a HCC biomarker due to its prognosis significance.
A:
Is identification of -glucosidase 1 as a biomarker and its high expression in hepatocellular carcinoma associated with resistance to chemotherapy drugs?