Detailed Instructions: Given a scientific passage and an answer, generate a question for the given answer.
See one example below:
Problem: Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Solution: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Explanation: The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.

Problem: Passage: Extracellular Matrix of Animal Cells Most animal cells release materials into the extracellular space. The primary components of these materials are proteins, and the most abundant protein is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. Collectively, these materials are called the extracellular matrix (Figure 4.27). Not only does the extracellular matrix hold the cells together to form a tissue, but it also allows the cells within the tissue to communicate with each other. How can this happen?. Answer: collagen
Solution:
The extracellular matrix of most animal cells contains abundant amounts of what protein, which helps hold things together?