Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor. We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 g per kilogram of body weight) or placebo on days 1 and 56. The primary efficacy measures were knee pain while walking and the patient's global assessment of response to therapy. We also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT-OARSI); and safety. When averaged over weeks 1 through 16, the mean reductions from baseline in knee pain while walking ranged from 45 to 62% with various doses of tanezumab, as compared with 22% with placebo (P<0.001). Tanezumab, as compared with placebo, was also associated with significantly greater improvements in the response to therapy as assessed with the use of the patients' global assessment measure (mean increases in score of 29 to 47% with various doses of tanezumab, as compared with 19% with placebo; P0.001). The rate of response according to the OMERACT-OARSI criteria ranged from 74 to 93% with tanezumab treatment, as compared with 44% with placebo (P<0.001). The rates of adverse events were 68% and 55% in the tanezumab and placebo groups, respectively. The most common adverse events among tanezumab-treated patients were headache (9% of the patients), upper respiratory tract infection (7%), and paresthesia (7%). In this proof-of-concept study, treatment with tanezumab was associated with a reduction in joint pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.).
[EX A]: What is the target of tanezumab?

[EX Q]: Munich sincerely invites you to join the 2016 0ktoberfest--the biggest celebration of its kind in Europe. Drink beer by the liter, eat traditional Bavarian food, listen to traditional Bavarian music as well as more up-to-date music, and enjoy yourself with hundreds of other people from all over the world, dancing and singing the hours away. Oktoberfest 2016 begins on Saturday 17th September and runs through to Monday 3rd October 2016. Don't miss the events during Oktoberfest! Grand entry of the Oktoberfest landlords and breweries Date: Saturday, 17th September 2016 Duration: about 45 minutes This is the official prelude to the opening of the Oktoberfest and involves about 1,000 participants, including the landlords' families in decorated carriages, the magnificent horse-drawn drays, waitresses on decorated floats and all the beer tent bands. Oktoberfest Costume and Riflemen-s Parade Date: Sunday, 18th September 2016 Duration:2-2 1/2 hours, about 8000 performers,7 km distance A varied succession of regional costume groups, "troops" in historical uniforms, marching bands, riflemen, thoroughbred horses, oxen, cows, goats, floats displaying typical local traditions and historic carriages all pass by in a 7-kilometer-long procession through the streets of the city center. Open-Air Oktoberfest Music Date: Sunday, 25th September 2016 Place: on the steps of the Bavaria statue At the traditional open-air concert on the second Sunday of the Oktoberfest, all the instruments that make up typical Bavarian wind band music can be heard. The bands from all of the tents come together at the steps under the Bavaria statue to play the most well-known songs and marches of Oktoberfest together while being conducted by distinguished Munich personalities.
[EX A]: When will visitors see costume soldiers marching on the street?

[EX Q]: Once upon a time there was a crook who only thought about how to get money. What he hated most was when people were polite to each other, saying things like "please", "thank you", and "don't mention it". The crook thought all those kinds of words were a waste, so he spent a lot of time inventing a machine which could steal words. With this machine, he planned to steal "please", "thank you", "don't mention it", and similar words people used to be polite. After he stole these words, he intended to take them apart and sell the letters to book publishers. After he started up his machine, people would open their mouths, intending to say kind and polite things, but nothing came out. All those words ended up inside the big machine. The crook was happy with his success, but he didn't count on a couple of very special little girls. Those girls were deaf, and had to communicate with sign language. Because the machine couldn't steal gestures, these girls continued being kind and polite. Soon they realized what had been happening to everyone else, and they found out about the crook and his plan. The girls followed him and found the machine busy separating all the words into letters. They approached the machine and started being polite to each other. Try as it might, the machine couldn't steal those words, and it started to suffer a power overload . Finally, it exploded, sending all the letters it had gathered flying into the sky. These letters started coming down, like rain, and most ended up in the sea. After that, everyone could be polite again. Seeing all those letters fall into the sea, those little girls had an idea. A little while later they opened a factory, making alphabetic spaghetti soup!
[EX A]:
Why did the machine have no effect on the two girls?