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Before you let your guinea pig out of their cage, you need to make the room safe. Make sure you have nothing around the room that your guinea pig can get into, such as chemicals or cleaning supplies. Remove or pick up cords out of your guinea pig's reach. They may chew on them if they finds them on the floor. If you're worried about your guinea pig going to the bathroom on your carpet or flooring, lay down a layer of plastic or newspaper to catch any accidents. Put house plants out of reach. Many of them are toxic to guinea pigs. Remove plastic bags, as guineas like them, but they are not safe to play with. Don't forget to provide food and water for the time your guinea is out of her cage. Close any doors so the guinea pig can't escape. Also, keep any other pets, such as dogs or cats, out of the room while you have your guinea pig out of their cage. Also, warn family members you are letting the guinea pigs out, as they may open the door while they are on the floor. Guinea pigs like a challenge, so try making an obstacle course or maze out of cardboard. You can use a large piece of cardboard for the base or simply tape walls to the floor. Put in twists and turns, and have a treat ready at the end. Add interesting obstacles such as cardboard tubes or bridges. Tunnels are also a fun addition. Guinea pigs need exercise every day to keep from getting bored in their cages. Pull them out of their cage with two hands, and set them in the room you've made guinea pig-proof. Throw out a few toys to play with. If you want to socialize at the same time, get down on the floor with your guinea pig so that they can come investigate you. Even if they say they are for guinea pigs, these balls are not really designed for guinea pig use, and they can be dangerous for your pet's back. If your guinea pig does escape into the rest of your house, keep a cool head. Put your other pets away. Close any other escape routes, especially ones leading outdoors. Try to herd your guinea pig into a corner to catch her. If she holes up somewhere, know she will eventually come out to find food. Just be ready to catch her.
Make the room safe. Shut off the room. Create an obstacle course. Give your guinea pig time to roam. Avoid exercise balls. Catch your guinea pig.