Answer by taking a quote from the following article:

Meader was born in Waterville, Maine during one of the worst floods ever to hit New England: he often said he was born on "the night the West Bridge washed out". He was the only child of Charles Vaughn Meader, a millworker, and Mary Ellen Abbott. After his father broke his neck and drowned in a diving accident when Meader was only eighteen months old, his mother moved to Boston to work as a cocktail waitress, leaving Meader behind with relatives. A sometimes unruly and troubled child, Meader was sent to live with his mother in Boston at the age of five

In November 1963, Meader was busy recording a new comedy record, written by a different group of writers and not involving his Kennedy impersonation. On November 22, 1963, President Kennedy was assassinated in Dallas, Texas, and Kennedy's death effectively ended Meader's career. Copies of The First Family were pulled from stores and a JFK-related Christmas single by Meader that had been released by MGM's Verve Records shortly before the assassination was quickly withdrawn. Appearances that were already booked were canceled, including one for the Grammy Awards ceremony. An episode of The Joey Bishop Show was also pulled, which Meader filmed one week before the assassination. The episode was never aired and was reportedly destroyed. Meader reportedly first learned of President Kennedy's assassination after hailing a taxicab in Milwaukee, Wisconsin. The driver, recognizing his celebrity passenger, asked "Did you hear about Kennedy?" Meader thought the driver was telling a joke and responded "No, how does it go?" The driver then informed him of the sad news, and from the taxi's radio Meader heard the breaking news bulletins for the first time. According to several sources, standup comedian Lenny Bruce went on with his November 22 nightclub show as scheduled. Just hours after Kennedy's death, Bruce walked onstage, stood silently for several moments, then said sadly, "Boy, is Vaughn Meader fucked." The joke proved true. Meader discovered that he was so completely typecast as a Kennedy impersonator that he could not find anyone willing to hire him for any of his other talents. His non-Kennedy album for Verve Records, Have Some Nuts!!!, came out to minimal attention in early 1964. A similar follow-up If The Shoe Fits... was released in late 1964, and included sketches on almost everything except the Kennedys, but sales were meager at best. Meader's income evaporated, new-found friends and associates stopped calling, and by 1965 Meader was virtually broke. Sinking into depression, he became addicted to alcohol and drugs, and was forced to take whatever work he could find. He reunited with Earle Doud in 1971 for an album called The Second Coming, a comedic look at what life would be like for Jesus if he had returned to earth around the time of Jesus Christ Superstar, but airplay and sales were virtually nonexistent.

What happened after the assassination?
Meader discovered that he was so completely typecast as a Kennedy impersonator that he could not find anyone willing to hire him for any of his other talents.