Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Q: Question: Is haploinsufficiency the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease?
Answer: The detailed characterization of this animal model provides the first in vivo evidence that Elovl4 haploinsufficiency is not the underlying key disease mechanism in STGD3. The results are consistent with a dominant negative mechanism for the deletion mutation. The Elovl4 knockout mouse is one of three complementary animal models that will help elucidate the disease mechanism.

A: no
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Q: Question: Do nAT1 genotypes predict response to mesalamine in patients with ulcerative colitis?
Answer: NAT1 genotypes do not predict response or side effects to mesalamine in patients with UC. Variations caused by non-genomic effects may be associated with the clinical response to 5-ASA.

A: no
****
Q: Question: Does preconditioning of skeletal myoblast-based engineered tissue constructs enable functional coupling to myocardium in vivo?
Answer: Although untreated skeletal myoblasts cannot couple to cardiomyocytes, we confirm that mechanical preconditioning enables transplanted skeletal myoblasts to functionally interact with cardiomyocytes invivo and, thus, reinvigorate the concept of skeletal myoblast-based cardiac cell therapy.

A:
yes
****