In this task, you are given a abstract of article and corresponding title of an article. Your task is to generate label "yes" if title is right for article, otherwise generate "no".
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Question: Abstract: The three-dimensional structure of an HNF-3/fork head DNA-recognition motif complexed with DNA has been determined by X-ray crystallography at 2.5 A resolution. This / protein binds B-DNA as a monomer, through interactions with the DNA backbone and through both direct and water-mediated major and minor groove base contacts, inducing a 13 bend. The transcription factor fold is very similar to the structure of histone H5. In its amino-terminal half, three -helices adopt a compact structure that presents the third helix to the major groove. The remainder of the protein includes a twisted, antiparallel -structure and random coil that interacts with the minor groove.. Title: Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options

Answer: no

Question: Abstract: Summary Signals transduced by Notch receptors are indispensable for T cell specification and differentiation of T lineage cells. However, the role of Notch signals during versus T lineage decision remains controversial. Here, we addressed this question by employing a clonal analysis of CD4 CD8 (DN) progenitor potential to position the divergence of and T cell lineages to the late DN2 to DN3 developmental stages. Accordingly, and precursor frequencies within these T cell progenitor subsets were determined, both in the presence and absence of Notch signaling through Delta-like 1. Notch signals were found to be critical for the DN to CD4 + CD8 + (DP) transition, irrespective of the identity (pT or ) of the inducing T cell receptor complex, whereas T cells developed from TCR-expressing T cell progenitors in the absence of further Notch ligand interaction. Collectively, our findings demonstrate a differential, stage-specific requirement for Notch receptor-ligand interactions in the differentiation of and T cells from T cell progenitors.. Title: Stage-Specific and Differential Notch Dependency at the and T Lineage Bifurcation

Answer: yes

Question: Abstract: CONTEXT Peristomal pyoderma gangrenosum (PPG), an unusual variant of pyoderma gangrenosum, has been reported almost exclusively in patients with inflammatory bowel disease (IBD) and is frequently misdiagnosed.
OBJECTIVE To better characterize the clinical manifestations, diagnosis, and management of PPG.
DESIGN, SETTING, AND PATIENTS Retrospective analysis of 7 patients with PPG observed in a university-affiliated community setting between 1988 and December 1999.
MAIN OUTCOME MEASURES Clinical and histopathologic features, associated disorders, and microbiologic findings.
RESULTS Two patients had Crohn disease, 2 had ulcerative colitis, and 3 had abdominal cancer. Five patients had at least 1 relapse of PPG after initial healing. Although 3 of 4 patients with IBD had active bowel disease, a parallel course with PPG occurred in only 1 patient. Both patients whose stoma was relocated developed an ulcer at the new site. Effective therapies included topical superpotent corticosteroids; intralesional injection of triamcinolone acetonide at the ulcer margin; topical cromolyn sodium; oral dapsone, prednisone, cyclosporine, mycophenolate mofetil; and intravenous infliximab.
CONCLUSION Our experiences demonstrate that although PPG has been most often reported in patients with IBD, it may occur in the absence of IBD. Biopsy of the skin lesion is not diagnostic but excludes other causes. Relocation of the stoma may be associated with a new ulceration and should be avoided. Trauma to the skin of a predisposed patient may elicit the pustules or ulcerations associated with pathergy. JAMA. 2000;284:1546-1548.. Title: Potential use of -secretase modulators in the treatment of Alzheimer disease.

Answer:
no