Active quarterback Tom Brady holds the records for most wins with 220, most regular season wins with 195, and most postseason wins with 25, as of Week 16 of the 2017 NFL season. Having played the entirety of his career with the New England Patriots, each of Brady's win records also apply to wins with a single team.

Who had the most wins in the nfl? Okie... think carefully first, then make a decision:
The relevant sentence in the passage is: Active quarterback Tom Brady holds the records for most wins with 220, most regular season wins with 195, and most postseason wins with 25, as of Week 16 of the 2017 NFL season. So, the answer is Tom Brady.