Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Rigel Pharmaceuticals Inc is developing fostamatinib, a prodrug of the spleen tyrosine kinase (Syk) inhibitor R-406, for the potential treatment of autoimmune diseases such as rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and B-cell lymphomas. Syk is a key mediator of Fc and B-cell receptor signaling in inflammatory cells, such as B-cells, mast cells, macrophages and neutrophils. Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. In a phase II clinical trial, fostamatinib treatment effectively improved American College of Rheumatology response rates in patients with RA. Preclinical studies and phase II trials also suggested the potential of using fostamatinib for the treatment of ITP and B-cell lymphomas, by increasing platelet counts and inducing response rates, respectively. Fostamatinib is orally bioavailable and was well tolerated in phase I and II trials, with the most common side effect being gastrointestinal symptoms. At the time of publication, phase II trials for fostamatinib were ongoing in patients with RA, ITP and B-cell lymphomas. The Syk inhibitor appears to be a promising therapeutic for immunological diseases, but further data are required to establish the efficacy and long-term safety of the drug in humans.
Which enzyme is inhibited by a drug fostamatinib?

One day, a slave owner entered a local store and threatened a young boy who was his slave. At first, the slave refused to move and ran for the door. The slave owner reached for a heavy weight. He threw it at his slave. Instead, it hit Harriet on the head. Harriet almost died. For the rest of her life, she carried the mark of a deep wound on her head. Miser Brodas felt he never needed Harriet. He decided to sell her. Harriet thought of a way to prevent this. Each time she was shown to someone who might buy her, she acted as if she were falling asleep. After a while, Mister Brodas gave up the hope of selling Harriet. He sent her back to the fields. At 24 she married a free black man, John Tubman. By then, Harriet was sure she should escape. In 1849, Mister Brodas died. His slaves probably would be sold to further South. John Tubman tried to make Harriet forget about running away. Harriet decided she must end her marriage and that she needed to tell her family that she was leaving. Harriet escaped for Pennsylvania where slavery was banned there. Once she hid under hay that had been cut from the fields. Another time, she wore men's clothing. Finally, she arrived in Pennsylvania. Now that Harriet was free, she didn't forget other slaves in Maryland. During the next ten years, she freed her parents and other family members. She traveled back and forth eighteen times, helping about 300 slaves escape. She became an expert at hiding from slave hunters. At one time, anyone finding Harriet was promised 40,000dollars for catching her--dead or alive. The people she helped called her Moses. She had rescued them from slavery just as the biblical Moses rescued the Jews. After the Civil War began, Harriet started to spy for the North. She also served as a nurse. After four years of bloody fighting, the North won the war. Abraham Lincoln freed the slaves in 1863. There was no longer any need for Harriet to be Moses.
We know from the passage that Harriet was Mister Brodas' .

RNA editing is proposed as a modulator of transcriptomes, but its biological impact has not been fully elucidated. In particular, its importance for transposable elements is controversial. We found RNA editing on antisense read-through transcripts of KP elements, one of the deletion derivatives of P transposable elements in Drosophila melanogaster. Three kinds of RNA editing were detected at 20 sites around the terminal inverted repeats (TIR); 15 A-to-G, four U-to-C, and one C-to-U conversions. A-to-G conversions are suggested to be attributed to A-to-I RNA editing on KP element RNAs, because inosine (I) in RNA is recognized as G by reverse transcriptase. TIRs were deduced to form dsRNAs as a putative target of ADAR. This is the first report of RNA editing on mobile elements of Drosophila.
Which is the major RNA editing enzyme in Drosophila melanogaster?