Given an abstract of a paper, generate a title for this paper such that conveys the key focus of the paper.

Example Input: Abstract: Six subjects (25.3 +/- 3.3 yr, mean +/- SD) exercised for 60 min at 42 +/- 4 [low (L)], 55 +/- 6 [moderate (M)], and 67 +/- 4 %VO2max [high (H)] in a moderate environment. Sweat collected from upper back (UB), lower back (LB), midchest (MC), stomach (S), and thigh (T) areas as well as by whole-body washdown (W) was analyzed for urea nitrogen (N). With the exception of the L where all regional measures were similar, all sites overestimated W (several significantly, P less than 0.05). Regression analysis estimations of W (mg/h) from regional collections were as follows--L: W = 0.727 (S) - 1.366(UB) + 1.181(T) + 65.470 +/- 29.5, R = 0.90; M: W = 0.598(MC) - 0.649(UB) + 0.244(LB) + 43.238 +/- 30.4, R = 0.99; H: W = 0.274(S) - 0.560(T) + 0.223(MC) + 131.104 +/- 4.3, R = 0.99; All Intensities: W = 0.497(MC) - 0.483(T) + 0.112(LB) + 69.554 +/- 31.5, R = 0.96. W recovery of exogenous urea N applied to each subject's body was 98.3 +/- 2.7% (mean +/- SE). Interinvestigator reliability coefficient (r = 0.511) was significant (P less than 0.01) but relatively low and the between investigator urea N recovery (93.3 +/- 3.7 vs. 103.2 +/- 3.5%) was significantly different (P less than 0.05). Repeated W determinations by the same investigator were not different (P greater than 0.05), but intrainvestigator reliability coefficients differed widely (0.385 vs. 0.820). Together, these data indicate that W solute recovery can be high; however, both inter- and intrainvestigator reliability can vary.(ABSTRACT TRUNCATED AT 250 WORDS)
Example Output: Validity/reliability of sweat analysis by whole-body washdown vs. regional collections.

Example Input: Abstract: Studies in patients on dialysis have shown that aluminum (Al) accumulation in bone plays a major role in the pathogenesis of osteomalacia. It has been suggested that deferoxamine (DFO) may be beneficial in the treatment of aluminum-induced osteomalacia. The present studies were performed in four groups of uremic rats to determine if DFO and/or discontinuation of Al administration have an effect on bone histomorphometry and blood chemistries. The groups were: 1) uremic control 2) aluminum (0.75 to 1.0 mg/rat i.p., five times a week for twelve weeks): 3) aluminum + DFO, after twelve weeks Al was discontinued and the rats received DFO (75 mg/rat two times a week for nine weeks); 4) aluminum + time, after twelve weeks Al was discontinued and the rats were sacrificed after nine weeks. High levels of Al in serum and bone and low levels of PTH were seen in rats receiving Al. Bone histology revealed Al at the mineralization front, abnormal tetracycline uptake, and an increase in osteoid. DFO treatment did not significantly change the level of Al in bone, however both DFO treatment and discontinuation of Al reversed towards normal the above described lesions. In conclusion, these studies suggest that DFO and/or discontinuation of Al administration to rats with approximately 30% of renal function greatly improve aluminum-induced osteomalacia.
Example Output: The effects of discontinuation of aluminum exposure on aluminum-induced osteomalacia.

Example Input: Abstract: Eighty two patients with isolated optic neuritis were studied prospectively to determine the frequency with which multiple sclerosis developed and the factors which increased its risk. Patients were followed for 6 to 264 months (mean, 57 months). Twenty six patients (32%) developed clinically definite or probable multiple sclerosis during the period of follow-up. Actuarial analysis predicted that 42% would develop multiple sclerosis by 7 years. Of those patients who developed multiple sclerosis, 92% had symptoms within 4 years of the first attack of optic neuritis. The highest incidence of multiple sclerosis occurred in the 21-40 year age group. There was an increased risk of MS in patients with HLA-DR2 and HLA-B7 tissue types. The frequency of HLA-DR4 was increased in patients with optic neuritis alone compared to controls and to patients with multiple sclerosis, but further studies are required to confirm this finding.
Example Output:
Acute optic neuritis: a prospective study of risk factors for multiple sclerosis.