Problem: Sentence1: Make a phone call.
Sentence2: They make a cute couple.
Q: Does the term make mean the same thing in both these sentences?

Answer: different meanings

Problem: Sentence1: Please tell me how to do it.
Sentence2: Ellen told Helen about the situation.
Q: Does the term tell mean the same thing in both these sentences?

Answer: the same meaning

Problem: Sentence1: The sale will run for ten days.
Sentence2: The film runs 5 hours.
Q: Does the term run mean the same thing in both these sentences?

Answer: the same meaning

Problem: Sentence1: The young teacher had to substitute for the sick colleague.
Sentence2: The skim milk substitutes for cream -- we are on a strict diet.
Q: Does the term substitute mean the same thing in both these sentences?

Answer:
the same meaning