Instructions: Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).
Input: Abstract: Release of prostaglandin E (PGE) was examined in leukocyte cultures from patients with definite MS who had had at least one recent exacerbation, others with chronic progressive or stable MS, and healthy controls. MS patients had higher baseline levels of PGE than did controls. Patients with active symptoms exhibited a sharp increase in PGE release early in or just before the onset of clinical symptoms. Levels dropped early in exacerbation immediately after the burst in PGE synthesis activity. Values gradually increased to control levels and then to preexacerbation levels. Similar rises and falls were not seen in stable MS. MS patients may have a circulating population of activated leukocytes that produce PGE.
Which is the apt title for the abstract? option1: Prostaglandin release in multiple sclerosis: correlation with disease activity. option2: Infections of the lower extremities due to gas-forming and non-gas-forming organisms [published erratum appears in South Med J 1987 Mar;80(3):319]
Output:
Prostaglandin release in multiple sclerosis: correlation with disease activity.