Question: Information: - Grey's Anatomy is an American medical drama television series that premiered on American Broadcasting Company (ABC) as a mid-season replacement on March 27, 2005. The series focuses on the fictional lives of surgical interns, residents, and attendings as they gradually evolve into seasoned doctors, while trying to maintain personal lives and relationships. The title is a play on "Gray's Anatomy", a human anatomy textbook by Henry Gray. The show's premise originated with Shonda Rhimes, who serves as an executive producer, along with Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding, and Allan Heinberg. Although the show is set in Seattle at the fictional Grey-Sloan Memorial Hospital (Formerly Seattle Grace-Mercy West) it is primarily filmed in Los Angeles, California. The show was originally titled "Complications" following the complicated medical procedures and personal lives of the cast. - The Hot Zone: A Terrifying True Story is a best-selling 1995 nonfiction thriller by Richard Preston about the origins and incidents involving viral hemorrhagic fevers, particularly ebolaviruses and marburgviruses. The basis of the book was Preston's 1992 "New Yorker" article "Crisis in the Hot Zone". - Wolfgang Petersen (born 14 March 1941) is a German film director and screenwriter. He was nominated for two Academy Awards for the 1981 World War II submarine warfare film "Das Boot" (1981). His other films include "The NeverEnding Story" (1984), "Enemy Mine" (1985), "In the Line of Fire" (1993), "Outbreak" (1995), "Air Force One" (1997), "The Perfect Storm" (2000), "Troy" (2004), and "Poseidon" (2006). - Outbreak is a 1995 American medical disaster film directed by Wolfgang Petersen and very loosely based on Richard Preston 's non-fiction book The Hot Zone . The film stars Dustin Hoffman , Rene Russo and Morgan Freeman , and co-stars Cuba Gooding , Jr. , Kevin Spacey , Donald Sutherland and Patrick Dempsey . The film focuses on an outbreak of a fictional Ebola - like virus called Motaba in Zaire and later in a small town in the United States . Its primary settings are government disease control centers USAMRIID and the CDC , and the fictional town of Cedar Creek , California . Outbreak 's plot speculates how far military and civilian agencies might go to contain the spread of a deadly contagion . The film was released on March 10 , 1995 and proved a box office success . It was nominated for various awards but failed to garner any major award nominations . It also raised various '' what - if '' scenarios : media outlets began to question what the government would really do in a similar situation and if the CDC has plans in case an outbreak ever does occur . A real - life outbreak of the Ebola virus was occurring in Zaire during the time of the film 's release . - Rene Marie Russo (born February 17, 1954) is an American actress, producer and former model. - A film director is a person who directs the making of a film. Generally, a film director controls a film's artistic and dramatic aspects, and visualizes the script while guiding the technical crew and actors in the fulfillment of that vision. The director has a key role in choosing the cast members, production design, and the creative aspects of filmmaking. Under European Union law, the director is viewed as the author of the film. - The Usual Suspects is a 1995 American crime thriller film directed by Bryan Singer and written by Christopher McQuarrie. It stars Stephen Baldwin, Gabriel Byrne, Benicio del Toro, Kevin Pollak, Chazz Palminteri, Pete Postlethwaite, and Kevin Spacey. - Million Dollar Baby is a 2004 American sports drama film directed, co-produced and scored by Clint Eastwood, and starring Eastwood, Hilary Swank and Morgan Freeman. This film is about an underappreciated boxing trainer, the mistakes that haunt him from his past, and his quest for atonement by helping an underdog amateur boxer achieve her dream of becoming a professional. - The Shawshank Redemption is a 1994 American drama film written and directed by Frank Darabont, and starring Tim Robbins and Morgan Freeman. Adapted from the Stephen King novella "Rita Hayworth and Shawshank Redemption", the film tells the story of Andy Dufresne, a banker who is sentenced to life in Shawshank State Penitentiary for the murder of his wife and her lover, despite his claims of innocence. During his time at the prison, he befriends a fellow inmate, Ellis Boyd "Red" Redding, and finds himself protected by the guards after the warden begins using him in his money-laundering operation. - An earthquake (also known as a quake, tremor or temblor) is the shaking of the surface of the Earth, resulting from the sudden release of energy in the Earth's lithosphere that creates seismic waves. Earthquakes can be violent enough to toss people around and destroy whole cities. The seismicity or seismic activity of an area refers to the frequency, type and size of earthquakes experienced over a period of time. - The Academy Award for Best Actor is an award presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It is given in honor of an actor who has delivered an outstanding performance in a leading role while working within the film industry. - Made of Honor (Made of Honour in the United Kingdom, Ireland, Canada and Australia) is a 2008 American romantic comedy film directed by Paul Weiland and written by Adam Sztykiel, Deborah Kaplan and Harry Elfont. The film stars Patrick Dempsey, Michelle Monaghan and Sydney Pollack, in his final screen appearance prior to his death less than a month after the film's release. - Richard Preston (born August 5, 1954) is a "New Yorker" writer and bestselling author who has written books about infectious disease, bioterrorism, redwoods and other subjects, as well as fiction. Whether journalistic or fictional, his writings are based on extensive background research and interviews. - Bioterrorism is terrorism involving the intentional release or dissemination of biological agents. These agents are bacteria, viruses, or toxins, and may be in a naturally occurring or a human-modified form. For the use of this method in warfare, see biological warfare. - Das Boot (German meaning "The Boat") is a 1981 German epic war film written and directed by Wolfgang Petersen, produced by Gunter Rohrbach, and starring Jurgen Prochnow, Herbert Gronemeyer and Klaus Wennemann. It has been exhibited both as a theatrical release and as a TV miniseries, and in several different home video versions of various running times. - The Screen Actors Guild Award (also known as the SAG Award) is an accolade given by the Screen Actors GuildAmerican Federation of Television and Radio Artists (SAG-AFTRA) to recognize outstanding performances in film and primetime television. The statuette given, a nude male figure holding both a mask of comedy and a mask of tragedy, is called "The Actor". It is tall, weighs over , is cast in solid bronze, and produced by the American Fine Arts Foundry in Burbank, California. - A natural disaster is a major adverse event resulting from natural processes of the Earth; examples include floods, hurricanes, tornadoes, volcanic eruptions, earthquakes, tsunamis, and other geologic processes. A natural disaster can cause loss of life or property damage, and typically leaves some economic damage in its wake, the severity of which depends on the affected population's resilience, or ability to recover and also on the infrastructure available. - The Academy Award for Best Supporting Actor is an award presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It is given in honor of an actor who has delivered an outstanding performance in a supporting role while working within the film industry. - Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection. VHFs may be caused by five distinct families of RNA viruses: the families "Arenaviridae", "Filoviridae", "Bunyaviridae", "Flaviviridae", and "Rhabdoviridae". All types of VHF are characterized by fever and bleeding disorders and all can progress to high fever, shock and death in many cases. Some of the VHF agents cause relatively mild illnesses, such as the Scandinavian "nephropathia epidemica" (a Hantavirus), while others, such as Ebola virus, can cause severe, life-threatening disease. - The genus Ebolavirus is a virological taxon included in the family "Filoviridae", order "Mononegavirales". The members of this genus are called ebolaviruses. The five known virus species are named for the region where each was originally identified: "Bundibugyo ebolavirus", "Reston ebolavirus", "Sudan ebolavirus", "Tai Forest ebolavirus" (originally "Cote d'Ivoire ebolavirus"), and "Zaire ebolavirus". The Ebola virus (EBOV) protein VP24 inhibits type I and II interferon (IFN) signaling by binding to NPI-1 subfamily karyopherin (KPNA) nuclear import proteins, preventing their interaction with tyrosine-phosphorylated STAT1 (phospho-STAT1). This inhibits phospho-STAT1 nuclear import. A biochemical screen now identifies heterogeneous nuclear ribonuclear protein complex C1/C2 (hnRNP C1/C2) nuclear import as an additional target of VP24. Co-immunoprecipitation studies demonstrate that hnRNP C1/C2 interacts with multiple KPNA family members, including KPNA1. Interaction with hnRNP C1/C2 occurs through the same KPNA1 C-terminal region (amino acids 424457) that binds VP24 and phospho-STAT1. The ability of hnRNP C1/C2 to bind KPNA1 is diminished in the presence of VP24, and cells transiently expressing VP24 redistribute hnRNP C1/C2 from the nucleus to the cytoplasm. These data further define the mechanism of hnRNP C1/C2 nuclear import and demonstrate that the impact of EBOV VP24 on nuclear import extends beyond STAT1. - A pandemic (from Greek "pan" "all" and "demos" "people") is an epidemic of infectious disease that has spread through human populations across a large region; for instance multiple continents, or even worldwide. A widespread endemic disease that is stable in terms of how many people are getting sick from it is not a pandemic. Further, flu pandemics generally exclude recurrences of seasonal flu. Throughout history, there have been a number of pandemics, such as smallpox and tuberculosis. One of the most devastating pandemics was the Black Death, killing over 75 million people in 1350. The most recent pandemics include the HIV pandemic as well as the 1918 and 2009 H1N1 pandemics. - Morgan Freeman (born June 1, 1937) is an American actor, producer and narrator. Freeman won an Academy Award in 2005 for Best Supporting Actor with "Million Dollar Baby" (2004), and he has received Oscar nominations for his performances in "Street Smart" (1987), "Driving Miss Daisy" (1989), "The Shawshank Redemption" (1994) and "Invictus" (2009). He has also won a Golden Globe Award and a Screen Actors Guild Award. - The Academy Awards, or "Oscars", is an annual American awards ceremony hosted by the Academy of Motion Picture Arts and Sciences (AMPAS) to recognize excellence in cinematic achievements in the United States film industry as assessed by the Academy's voting membership. The various category winners are awarded a copy of a statuette, officially called the Academy Award of Merit, which has become commonly known by its nickname "Oscar." The awards, first presented in 1929 at the Hollywood Roosevelt Hotel, are overseen by AMPAS. - In the Line of Fire is a 1993 American action thriller film, directed by Wolfgang Petersen and starring Clint Eastwood, John Malkovich and Rene Russo. Written by Jeff Maguire, the film is about a disillusioned and obsessed former CIA agent who attempts to assassinate the President of the United States and the Secret Service agent who tracks him. Eastwood's character is the sole active-duty Secret Service agent remaining from the detail guarding John F. Kennedy in Dallas, Texas, at the time of his assassination in 1963. The film also stars Dylan McDermott, Gary Cole, John Mahoney, and Fred Thompson. - Dustin Lee Hoffman (born August 8, 1937) is an American actor and a director, with a career in film, television, and theatre since 1960. - The genus Marburgvirus is the taxonomic home of one species, "Marburg marburgvirus", whose members are the two known marburgviruses, Marburg virus (MARV) and Ravn virus (RAVV). Both viruses cause Marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever, and both are Select Agents, World Health Organization Risk Group 4 Pathogens (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogens, Centers for Disease Control and Prevention Category A Bioterrorism Agents, and are listed as a Biological Agents for Export Control by the Australia Group. - Donald McNichol Sutherland, (born 17 July 1935) is a Canadian actor whose film career spans six decades. - Kevin Spacey Fowler (born July 26, 1959), better known as Kevin Spacey, is an American actor, film director, producer, screenwriter, and singer. He began his career as a stage actor during the 1980s before obtaining supporting roles in film and television. He gained critical acclaim in the early 1990s that culminated in his first Academy Award for Best Supporting Actor for the neo-noir crime thriller "The Usual Suspects" (1995), and an Academy Award for Best Actor for midlife crisis-themed drama "American Beauty" (1999). - World WarII (often abbreviated to WWII or WW2), also known as the Second World War, was a global war that lasted from 1939 to 1945, although related conflicts began earlier. It involved the vast majority of the world's nationsincluding all of the great powerseventually forming two opposing military alliances: the Allies and the Axis. It was the most widespread war in history, and directly involved more than 100 million people from over 30 countries. In a state of "total war", the major participants threw their entire economic, industrial, and scientific capabilities behind the war effort, erasing the distinction between civilian and military resources. Marked by mass deaths of civilians, including the Holocaust (in which approximately 11 million people were killed) and the strategic bombing of industrial and population centres (in which approximately one million were killed, and which included the atomic bombings of Hiroshima and Nagasaki), it resulted in an estimated 50 million to 85 million fatalities. These made World WarII the deadliest conflict in human history. - A film genre (or ) is a motion picture category based on similarities in either the narrative elements or the emotional response to the film (namely, serious, comic, etc.). Most theories of film genre are borrowed from literary genre criticism. The basic genres include fiction and documentary, from which subgenres have emerged, such as docufiction and docudrama. Other subgenres include the courtroom and trial-focused drama known as the legal drama. Types of fiction which may seem unrelated can also be combined to form hybrid subgenres, such as the melding of horror and comedy in the "Evil Dead" films. Other popular combinations are the romantic comedy and the action comedy film. - Golden Globe Awards are accolades bestowed by the 93 members of the Hollywood Foreign Press Association, recognizing excellence in film and television, both domestic and foreign. - A disaster film is a film genre that has an impending or ongoing disaster as its subject and primary plot device. Such disasters include natural disasters such as floods, earthquakes or asteroid collisions, accidents such as shipwrecks or airplane crashes, or calamities like worldwide disease pandemics. The films usually feature some degree of build-up, the disaster itself and sometimes the aftermath, usually from the point of view of specific individual characters or their families. - Patrick Galen Dempsey (born January 13, 1966) is an American actor and race car driver, best known for his role as neurosurgeon Dr. Derek "McDreamy" Shepherd on "Grey's Anatomy". He saw early success as an actor, starring in a number of films in his early 20s, including "Can't Buy Me Love" (1987) and "Loverboy" (1989). In the 1990s, he mostly appeared in smaller roles in film, such as "Outbreak" (1995), and television, before landing a lead role in "Sweet Home Alabama" (2002), a surprise box office hit. He has since then starred in a number of other films, including "Enchanted" (2007), "Made of Honor" (2008), "Valentine's Day" (2010), "Flypaper" (2011), "Freedom Writers" (2007), and "" (2011). - Freedom Writers is a 2007 film starring Hilary Swank, Scott Glenn, Imelda Staunton and Patrick Dempsey. - An actor (or actress for females; see terminology) is a person who portrays a character in a performance. The actor performs "in the flesh" in the traditional medium of the theatre, or in modern mediums such as film, radio, and television. The analogous Greek term is, literally "one who answers". The actor's interpretation of their role pertains to the role played, whether based on a real person or fictional character. Interpretation occurs even when the actor is "playing themselves", as in some forms of experimental performance art, or, more commonly; to act, is to create, a character in performance. - A screenplay writer, screenwriter for short, scriptwriter or scenarist is a writer who practices the craft of screenwriting, writing screenplays on which mass media such as films, television programs, comics or video games are based. Given the information above, choose from the list below the object entity that exhibits the relation 'main subject' with the subject 'outbreak '. Choices: - actor - animal - assassination - boxing - canada - comedy - comic - company - crime - design - epidemic - family - film - film industry - filmmaking - history - hollywood - hotel - july - law - life - model - murder - organization - outbreak - race - television - terrorism - the holocaust - time - true - united kingdom - war - world war ii - writer
Answer:
epidemic