In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Ex Input:
Paragraph: Primary human airway epithelial cell (hAEC) cultures represent a universal platform to propagate respiratory viruses and characterize their host interactions in authentic target cells. To further elucidate specific interactions between human respiratory viruses and important host factors in the airway epithelium, it is important to make hAEC cultures amenable to genetic modification. However, the short and finite lifespan of primary cells in cell culture creates a bottleneck for the genetic modification of these cultures. In the current study, we show that the incorporation of the Rho-associated protein kinase (ROCK) inhibitor (Y-27632) during cell propagation extends the life span of primary human cells in vitro and thereby facilitates the incorporation of lentivirus-based expression systems. Using fluorescent reporters for fluorescence-activated cell sorting (FACS)-based sorting, we generated homogenously fluorescent hAEC cultures that differentiate normally after lentiviral transduction. As a proof-of-principle, we demonstrate that host gene expression can be modulated post-differentiation via inducible short hairpin (sh)RNA-mediated knockdown. Importantly, functional characterization of these transgenic hAEC cultures with exogenous poly (I:C), as a proxy for virus infection, demonstrates that such modifications do not influence the host innate immune response. Moreover, the propagation kinetics of both human coronavirus 229E (HCoV-229E) and human respiratory syncytial virus (hRSV) were not affected. Combined, these results validate our newly established protocol for the genetic modification of hAEC cultures, thereby unlocking a unique potential for detailed molecular characterization of virus-host interactions in human respiratory epithelium.
Title: Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus-Host Interactions

Ex Output:
False

Ex Input:
Paragraph: Pulmonary arterial hypertension (PAH) is a chronic lung disease with poor diagnosis and limited therapeutic options. The currently available therapies are ineffective in improving the quality of life and reducing mortality rates. There exists a clear unmet medical need to treat this disease, which necessitates the discovery of novel therapeutic targets/agents for safe and successful therapy. An altered renin-angiotensin system (RAS) has been implicated as a causative factor in the pathogenesis of PAH. Angiotensin II (Ang II), a key effector peptide of the RAS, can exert deleterious effects on the pulmonary vasculature resulting in vasoconstriction, proliferation, and inflammation, all of which contribute to PAH development. Recently, a new member of the RAS, angiotensin converting enzyme 2 (ACE2), was discovered. This enzyme functions as a negative regulator of the angiotensin system by metabolizing Ang II to a putative protective peptide, angiotensin-(1-7). ACE2 is abundantly expressed in the lung tissue and emerging evidence suggests a beneficial role for this enzyme against lung diseases. In this review, we focus on ACE2 in relation to pulmonary hypertension and provide proof of principle for its therapeutic role in PAH.
Title: ACE2, a promising therapeutic target for pulmonary hypertension

Ex Output:
False

Ex Input:
Paragraph: Meaningfully synthesizing single case experimental data from intervention studies comprised of individuals with low incidence conditions and generating effect size estimates remains challenging. Seven effect size metrics were compared for single case design (SCD) data focused on teaching speech generating device use to individuals with intellectual and developmental disabilities (IDD) with moderate to profound levels of impairment. The effect size metrics included percent of data points exceeding the median (PEM), percent of nonoverlapping data (PND), improvement rate difference (IRD), percent of all nonoverlapping data (PAND), Phi, nonoverlap of all pairs (NAP), and Tau novlap . Results showed that among the seven effect size metrics, PAND, Phi, IRD, and PND were more effective in quantifying intervention effects for the data sample (N = 285 phase or condition contrasts). Results are discussed with respect to issues concerning extracting and calculating effect sizes, visual analysis, and SCD intervention research in IDD. effect size metric; speech generating devices; single case design; intellectual and developmental disabilities; evidence-based practices Evidence-based practice (EBP) has become a standard for an increasing number of educational and human services disciplines (American Speech-Language-Hearing domains of applied research, meta-analyses can be more challenging to implement because of the lack of agreed upon effect size metrics (Lipsey & Wilson, 2001; Shadish, Hedges, & Pustejovsky, 2014) . One area where this is particularly evident involves intervention research with low-incidence populations including individuals with intellectual and developmental disabilities (IDD) with moderate to profound levels of impairment. In the specific area of speech generating device (SGD) interventions for individuals with IDD with moderate to profound levels of impairment, for example, the population is extremely heterogeneous. This has resulted in a preponderance of single case design (SCD) studies for which there is not a standard effect size metric. In this article, we used the results from SCD SGD intervention studies as a vehicle to further evaluate different non-parametric effect size metrics from SCD studies. Our rationale was, in part, pragmatic. That is, the literature specific to SGD and severe disabilities is a manageable literature. Additionally, SGDs represent an area of a relatively rapid growth with tablet-based systems emerging and proliferating (Kuster, 2012; McNaughton & Light, 2013) . In the following sections we provide a brief overview of the literature addressing SGD and SCD. Subsequently, we provide a rationale for the SCD effect size comparisons that were conducted.
Title: Comparing Single Case Design Overlap-Based Effect Size Metrics From Studies Examining Speech Generating Device Interventions HHS Public Access The Need for Effect Size Clarity for Applied Intervention Research With Low-Incidence Populations Using SGDs

Ex Output:
False