This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.
--------
Question: Around 2.5 million years ago (ending 11,600 years ago) was the geological period of the Ice Ages. Since approximately 600,000 years ago, six major Ice Ages have occurred, in which sea level dropped 120 m (390 ft) and much of the continental margins became exposed. In the Early Pleistocene, the Rhine followed a course to the northwest, through the present North Sea. During the so-called Anglian glaciation (~450,000 yr BP, marine oxygen isotope stage 12), the northern part of the present North Sea was blocked by the ice and a large lake developed, that overflowed through the English Channel. This caused the Rhine's course to be diverted through the English Channel. Since then, during glacial times, the river mouth was located offshore of Brest, France and rivers, like the Thames and the Seine, became tributaries to the Rhine. During interglacials, when sea level rose to approximately the present level, the Rhine built deltas, in what is now the Netherlands.

Answer: What period was 2.5 million years ago?

Question: The ecclesiastical structure of the Roman Empire survived the movements and invasions in the west mostly intact, but the papacy was little regarded, and few of the western bishops looked to the bishop of Rome for religious or political leadership. Many of the popes prior to 750 were more concerned with Byzantine affairs and eastern theological controversies. The register, or archived copies of the letters, of Pope Gregory the Great (pope 590604) survived, and of those more than 850 letters, the vast majority were concerned with affairs in Italy or Constantinople. The only part of Western Europe where the papacy had influence was Britain, where Gregory had sent the Gregorian mission in 597 to convert the Anglo-Saxons to Christianity. Irish missionaries were most active in Western Europe between the 5th and the 7th centuries, going first to England and Scotland and then on to the continent. Under such monks as Columba (d. 597) and Columbanus (d. 615), they founded monasteries, taught in Latin and Greek, and authored secular and religious works.

Answer: When did Gregory the Great become pope?

Question: Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.

Answer:
What can be used for immediate treatment for MI?