You will be given a definition of a task first, then some input of the task.
Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.

Beta2-glycoprotein I (2GPI) is a highly abundant glycoprotein in plasma. Our previous study demonstrated strong 2GPI expression in hepatitis B-related hepatocellular carcinoma (HCC) tissue and the combination of 2GPI and hepatitis B surface antigen (HBsAg) was shown to significantly activate the nuclear factor kappa B (NF-B). To investigate whether lipopolysaccharide (LPS) enhances 2GPI activation of NF-B and the expression of downstream factors (e.g., tumor necrosis factor alpha, TNF-; interleukin-1 beta, IL-1; alpha-fetoprotein, AFP) in the human hepatoma cell line, SMMC-7721.', 'Experimental samples were divided into 4 groups as follows: Group A--blank cell group (SMMC-7721); group B--low, medium, and high LPS concentration groups (1 ng/mL; 10 ng/mL; and 100 ng/mL, respectively); group C--2GPI transfected group; and group D--2GPI + low, medium, or high concentrations from the LPS affected group. Activation of NF-B was evaluated using laser scanning confocal microscopy. Expression of downstream factors was measured by ELISA.', 'Degrees of NF-B activation in groups B, C, and D were varied. NF-B activation in group D was the most significant, and the expressions of downstream factors, TNF- and IL-1, were the highest level of activation among the groups (p < 0.05), showing an LPS dose-dependency.
Output:
0