Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: It has been reported that the R497K polymorphism of the epidermal growth factor receptor (EGFR) gene has attenuated functions in ligand binding, tyrosine kinase activation, and growth stimulation. On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib. We investigated the EGFR mutations and/or R497K polymorphism statuses in 225 surgically treated NSCLC cases. 192 adenocarcinoma cases were included. The presence or absence of EGFR polymorphism of exon 13 was analyzed by PCR-RFLP method. EGFR mutations at kinase domain were found from 95 of 225 lung cancer patients. In 86.2% of patients, homo- or heterozygous Lys497 allele was present. No correlation existed between R497K EGFR genotype and clinico-pathological features, such as gender, smoking status, and pathological subtypes. EGFR mutation status was not correlated with R497KEGFR genotype of lung cancers. In node-negative patients, R497KEGFR genotype was not correlated with disease outcome. In node-positive patients, however, R497K EGFR was significantly associated with better overall survival. This association was attributable to neo-adjuvant or adjuvant chemotherapy. In 46 total gefitinib treated NSCLC patients, the prognosis was not different between the EGFR wild type (GG) patients and AG+AA patients. R497KEGFR polymorphism might be associated with favorable prognosis of advanced lung cancers and correlated with chemosensitivity.
[EX A]: Mutations in which gene determine response to both erlotinib and gefitinib?

[EX Q]: Salt Flat Utah, 1873. Stubby Preston (Fabio Testi) a card-shard and gambling trickster, arrives in the small Wild West town to practice his art at the local casino. However, the town sheriff (Donald O'Brien) recognizes him climbing out of the stagecoach and within minutes, he is in a jail cell for the night and his marked cards are burned. Stubby's cell-mates are Emmanuelle 'Bunny' O'Neill (Lynne Frederick) a young prostitute; Bud (Harry Baird), a mentally disturbed black man who is obsessed with the dead; and Clem (Michael J. Pollard), the town drunkard. During the night, a masked posse of men wreck havoc throughout the settlement. Fearing for their safety as the massacre progresses, the prisoners demand to be realeased, but the sheriff refuses. The following morning, the sheriff, amused by Stubby's ways, allows them to leave town, pointing them to an abandoned wagon as their means of transportation. The sheriff also tells them that the massacre was all his idea to reclaim the town from lawlessness.The four released convicts decide to travel together, and Stubby takes a liking to Bunny. As they travel, aiming to his the next big town over 200 miles away, a friendship develops between the four reprobates. During their first stop for the night, Bunny reveals that she's eight months pregnant, having gotten knocked up by a client in Salt Flat and has been hiding it with oversized dresses. The following day, the four have an encounter with a group of Christian missionaries from Switzerland where Stubby has Bunny pose as his wife, who's happy about the charade.Afterwards, the four's idyll is interrupted by appearance of a Mexican sharpshooter called Chaco (Tomas Milian). Despite initial suspicious, he is welcomed into the group. Chaco displays his shooting skills by shooting rabbits and ducks for their meal for the night. But he shows a sinister side when the group is attacked by three posse members from Salt Flat, and Chaco gleefully shoots all three of them, and sadistically tortures the one surviving posse member. That evening, Chaco persuades the group to take peyote with him. Stubby, secretly spits out the hallucinogenic cactus, suspicious alerted, but the rest of the party accepts. Chaco then amuses himself with Clem, humiliating the drug-addled alcoholic by ordering that he crawl and bark like a dog for some liquor. When Stubby attempts to make a run for it, Chaco subdues him and ties up the four travelers at gunpoint. As day breaks, Chaco rapes Bunny despite seeing her condition. Stubby swears to kill Chaco one day if he survives. The evil bandit then rides off on the wagon with all their gear, leaving them tied up in the desert, except for Clem who he shoots in the leg. Clem frees the others and they continue their trek on foot. As Clems wound worsens, Stubby is forced to remove the bullet and he and Bud carry him on a makeshift stretcher. Later, the group comes upon the aftermath of another attack by Chaco and two henchmen. The Christian wagoners, children and all, have all been slaughtered.The group's journey continues. Eventually the four friends see buildings ahead. The arrive in a small town in the pouring rain, but discover that it's a ghost town. The following morning is bright and sunny. Bud is ecastic when he discovers a graveyard full of friends to talk to. That evening, Clem gets more sicker from the infection of his wound. But he makes dying request that Stubby and Bunny to get married. The couple profess their love for one another and they kiss for the first time. The next morning, the couple decide to leave the ghost town. Bud elects to stay behind having learned to hunt animals for food. But Stubby and Bunny discover Clems mutilated dead body and learn that Bud has taken a liking to cannibalism as well. Stubby and Bunny leave Bud and his 'city of the dead' and head on out.A little later, the couple run into another one of Stubby's old acquaintances, the pseudo-Reverend Sullivan (Adolfo Lastretti). Stopping for
[EX A]: Who is operated on and dies from his wounds?

[EX Q]: The Lump of Coal is a Christmas short story written by Lemony Snicket and illustrated by Brett Helquist.
[EX A]:
What is the name of the ilustrator of the book The Lump of Coal?