TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Claude Rains and James Stewart in Mr. Smith Goes to Washington Play media Trailer James Stewart and Jean Arthur in a taxicab The governor of an unnamed western state, Hubert "Happy" Hopper (Guy Kibbee), has to pick a replacement for recently deceased U.S. Senator Sam Foley. His corrupt political boss, Jim Taylor (Edward Arnold), pressures Hopper to choose his handpicked stooge, while popular committees want a reformer, Henry Hill. The governor's children want him to select Jefferson Smith (James Stewart), the head of the Boy Rangers. Unable to make up his mind between Taylor's stooge and the reformer, Hopper decides to flip a coin. When it lands on edge and next to a newspaper story on one of Smith's accomplishments he chooses Smith, calculating that his wholesome image will please the people while his naivete will make him easy to manipulate. Junior Senator Smith is taken under the wing of the publicly esteemed, but secretly crooked, Senator Joseph Paine (Claude Rains), who was Smith's late father's friend. Smith develops an immediate attraction to the senator's daughter, Susan (Astrid Allwyn). At Senator Paine's home, Smith has a conversation with Susan, fidgeting and bumbling, entranced by the young socialite. Smith's naive and honest nature allows the unforgiving Washington press to take advantage of him, quickly tarnishing Smith's reputation with ridiculous front page pictures and headlines branding him a bumpkin. To keep Smith busy, Paine suggests he propose a bill. With the help of his secretary, Clarissa Saunders (Jean Arthur), who was the aide to Smith's predecessor and had been around Washington and politics for years, Smith comes up with a bill to authorize a federal government loan to buy some land in his home state for a national boys' camp, to be paid back by youngsters across America. Donations pour in immediately. However, the proposed campsite is already part of a dam-building graft scheme included in an appropriations bill framed by the Taylor political machine and supported by Senator Paine. Unwilling to crucify the worshipful Smith so that their graft plan will go through, Paine tells Taylor he wants out, but Taylor reminds him that Paine is in power primarily through Taylor's influence. Through Paine, the machine in his state accuses Smith of trying to profit from his bill by producing fraudulent evidence that Smith already owns the land in question. Smith is too shocked by Paine's betrayal to defend himself, and runs away. Saunders, who looked down on Smith at first, but has come to believe in him, talks him into launching a filibuster to postpone the appropriations bill and prove his innocence on the Senate floor just before the vote to expel him. In his last chance to prove his innocence, he talks non-stop for about 24 hours, reaffirming the American ideals of freedom and disclosing the true motives of the dam scheme. Yet none of the Senators are convinced. The constituents try to rally around him, but the entrenched opposition is too powerful, and all attempts are crushed. Owing to the influence of Taylor's machine, newspapers and radio stations in Smith's home state, on Taylor's orders, refuse to report what Smith has to say and even distort the facts against the senator. An effort by the Boy Rangers to spread the news in support of Smith results in vicious attacks on the children by Taylor's minions. Although all hope seems lost, the senators begin to pay attention as Smith approaches utter exhaustion. Paine has one last card up his sleeve: he brings in bins of letters and telegrams from Smith's home state, purportedly from average people demanding his expulsion. Nearly broken by the news, Smith finds a small ray of hope in a friendly smile from the President of the Senate (Harry Carey). Smith vows to press on until people believe him, but immediately collapses in a faint. Overcome with guilt, Paine leaves the Senate chamber and attempts to commit suicide, but is stopped by other senators. When he is stopped, he bursts back into the Senate chamber, loudly confessing to the whole scheme;

SOLUTION: Who plays Hopper?

PROBLEM: In Week 8, the Bears donned their 1940s throwback uniforms against the Carolina Panthers, who had the worst record in the NFC. The Bears scored first on Matt Forte's 13-yard touchdown run, which would be countered by Justin Medlock's 34-yard field goal. The Panthers then took the lead on Louis Murphy's fumble recovery; Panthers quarterback Cam Newton ran with the ball, and lost the ball when Bears safety Major Wright tackled him at the 1-yard line. The ball rolled into the endzone, where Murphy recovered it. Medlock would then kick three more field goals, and by the fourth quarter, the Panthers led 19-7. The tide eventually turned when Panthers punter Brad Nortman shanked a 6-yard punt, and Jay Cutler hit Kellen Davis on a 12-yard touchdown pass with less than seven minutes left in the game. On the first play of the Panthers' next drive, Tim Jennings intercepted Newton and returned the pick 25 yards to regain the lead 20-19, after Cutler's two-point conversion passing attempt was intercepted. Medlock later kicked another field goal to reclaim the lead 22-20 with 2:27 left in the game. Cutler would lead the Bears downfield, and Gould kicked a 41-yard field goal as time expired to give Chicago the victory. The kick was Gould's tenth game-winning field goal, and the first since 2010.

SOLUTION: Who is the Panther's kicker?

PROBLEM: The methylation of lysine residues of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Here, we report two crystal structures of SET7/9, a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet) determined at 1.7 and 2.3 A resolution. The structures reveal an active site consisting of: (i) a binding pocket between the SET domain and a c-SET helix where an AdoMet molecule in an unusual conformation binds; (ii) a narrow substrate-specific channel that only unmethylated lysine residues can access; and (iii) a catalytic tyrosine residue. The methyl group of AdoMet is directed to the narrow channel where a substrate lysine enters from the opposite side. We demonstrate that SET7/9 can transfer two but not three methyl groups to unmodified Lys4 of H3 without substrate dissociation. The unusual features of the SET domain-containing HMTase discriminate between the un- and methylated lysine substrate, and the methylation sites for the histone H3 tail.

SOLUTION:
What is the characteristic domain of histone methyltransferases?