Elizabeth's many historic visits and meetings include a state visit to the Republic of Ireland and reciprocal visits to and from the Pope. She has seen major constitutional changes, such as devolution in the United Kingdom, Canadian patriation, and the decolonisation of Africa. She has also reigned through various wars and conflicts involving many of her realms. She is the world's oldest reigning monarch as well as Britain's longest-lived. In 2015, she surpassed the reign of her great-great-grandmother, Queen Victoria, to become the longest-reigning British head of state and the longest-reigning queen regnant in world history.
In the history of what is Elizabeth the longest reigning queen?
world history

In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led inexorably to severe skin ulceration, neurological damage, and death.[citation needed]
Where is the Institute of Experimental Therapy located?
Berlin

Seattle also has large lesbian, gay, bisexual, and transgender populations. According to a 2006 study by UCLA, 12.9% of city residents polled identified as gay, lesbian, or bisexual. This was the second-highest proportion of any major U.S. city, behind San Francisco Greater Seattle also ranked second among major U.S. metropolitan areas, with 6.5% of the population identifying as gay, lesbian, or bisexual. According to 2012 estimates from the United States Census Bureau, Seattle has the highest percentage of same-sex households in the United States, at 2.6 per cent, surpassing San Francisco.
What is Seattle's ranking for same sex households as compared with the rest of the US?
highest percentage