Tampa Bay hosted Chicago at Wembley Stadium in London, England, their second time participating in the NFL International Series. Josh Freeman threw four interceptions, and Tampa Bay lost one fumble for five total turnovers. Chicago stretched out to a 21-5 lead before the Buccaneers staged a rally in the fourth quarter. Freeman threw two touchdown passes and the deficit was trimmed to 24-18 in the final two minutes. Freeman drove the Buccaneers to the Chicago 39-yard line, but the comeback was thwarted when he was intercepted with 37 seconds left. Running back LeGarrette Blount was inactive due to injury, and Earnest Graham left the game in the first quarter due to an ankle injury. Third-string running back Kregg Lumpkin was left to handle rushing duties, but managed only 15 yards.

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