Q: Is Route 66 generally unknown to Americans?
A: Route 66 was immortalized in the hit "Route 66" by Bobby Troupe. "Route 66" as a song has reached the Billboard Top Charts multiple times and is still played often.
The answer is no.

Q: Does the anatomy of a camel lend itself to jokes on Wednesdays?
A: Wednesday is often referred to as 'hump day' as a joke. Camels are known for having a significant hump.
The answer is yes.

Q: Would a birdwatcher pursue their hobby at a Philadelphia Eagles game?
A: Birdwatching is a recreational activity in which people observe and/or listen to the sounds of birds. Despite their name, the Philadelphia Eagles are a professional American Football team comprised of humans, not birds.
The answer is no.

Q: Could Katharine Hepburn have ridden the AirTrain JFK?
A:
The AirTrain JFK was built in December 17, 2003. Katharine Hepburn died on June 29, 2003.
The answer is no.