Q: I have a new situation: Uncle Tom and uncle Sam both have high cholesterol. Uncle Tom is on statin drugs and uncle Sam is not. But I can use this background: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. What is an answer for this question: Which uncle doesn't take an inhibitor that induces the expression of low density lipoprotein (LDL) receptors in the liver?
A: Sam
Question: I have a new situation: Marcus has a long day ahead of him. He woke up early, around 7 AM to start his day. For a research study he takes his blood pressure around 9 AM and continues on through his day. Around noon he takes his blood pressure again noting that it has increased a little. He takes his blood pressure one more time before going to bed around 10PM But I can use this background: Circadian rhythms are regular changes in biology or behavior that occur in a 24-hour cycle. In humans, for example, blood pressure and body temperature change in a regular way throughout each 24-hour day. Animals may eat and drink at certain times of day as well. Humans have daily cycles of behavior, too. Most people start to get sleepy after dark and have a hard time sleeping when it is light outside. In many species, including humans, circadian rhythms are controlled by a tiny structure called the biological clock . This structure is located in a gland at the base of the brain. The biological clock sends signals to the body. The signals cause regular changes in behavior and body processes. The amount of light entering the eyes helps control the biological clock. The clock causes changes that repeat every 24 hours. What is an answer for this question: Will an animals blood pressure be at its highest in the middle of the day or at its lowest?
Answer: highest
[Q]: I have a new situation: Birch town was located 20 miles away from Free town. Birch town's population was affected by viral respiratory diseases, while Free town's population caught bacterial respiratory diseases. But I can use this background: Many respiratory diseases are caused by pathogens. A pathogen is an organism that causes disease in another organism. Certain bacteria, viruses, and fungi are pathogens of the respiratory system. The common cold and flu are caused by viruses. The influenza virus that causes the flu is pictured below ( Figure below ). Tuberculosis, whooping cough, and acute bronchitis are caused by bacteria. The pathogens that cause colds, flu, and TB can be passed from person to person by coughing, sneezing, and spitting. Illnesses caused by bacteria can be treated with antibiotics. Those caused by viruses cannot. What is an answer for this question: Which town has more people that caught the flu?
****
[A]: Birch
input: Please answer the following: I have a new situation: Michael is planning on playing a prank on his older brother. He is going to take a bungee cord and stretch it and then release it so that it hits his older brother as he is sleeping. He is deciding whether to stretch the cord only partially or completely before releasing it. But I can use this background: Something that is elastic can return to its original shape after being stretched or compressed. This property is called elasticity . As you stretch or compress an elastic material like a bungee cord, it resists the change in shape. It exerts a counter force in the opposite direction. This force is called elastic force . The farther the material is stretched or compressed, the greater the elastic force becomes. As soon as the stretching or compressing force is released, elastic force causes the material to spring back to its original shape. You can watch a demonstration of elastic force at this URL: What is an answer for this question: Will stretching the bungee cord partially or completely result in more force when it's released?
++++++++++
output: completely
Please answer this: I have a new situation: John and Keith are two friends. They went to see an ophthalmologist for an eye cheek up. The doctor found that John had myopia, but Keith had normal eyes. He advised them according to his findings. But I can use this background: Nearsightedness, or myopia, is the condition in which nearby objects are seen clearly, but distant objects appear blurry. The Figure below shows how it occurs. The eyeball is longer (from front to back) than normal. This causes images to be focused in front of the retina instead of on the retina. Myopia can be corrected with concave lenses. The lenses focus images farther back in the eye, so they fall on the retina instead of in front of it. What is an answer for this question: Who would see distant objects less clearly, John or Keith?
++++++++
Answer: John
Question: I have a new situation: Jessica and Milly are two politicians currently in the running for governor of their city. They are in the process of having a debate that is being broadcast on local television. Mike, an avid environmentalist who is trying to decide who to vote for, has been watching the entire debate. He feels the most important issue when voting is saving the planet and the animals on it. The question that was just asked by the moderator was "what do you think should be done with the Earth's atmosphere?" Jessica responds that she thinks we should emit more anthropogenic gases. She believes that will lead to the best outcome for the world. Milly states that we need to decrease the amount of carbon dioxide and other gases in the atmosphere. But I can use this background: The dangers of global warming are being increasingly studied by a wide global consortium of scientists. These scientists are increasingly concerned about the potential long-term effects of global warming on our natural environment and on the planet. Of particular concern is how climate change and global warming caused by anthropogenic, or human-made releases of greenhouse gases, most notably carbon dioxide, can act interactively, and have adverse effects upon the planet, its natural environment and humans' existence. It is clear the planet is warming, and warming rapidly. This is due to the greenhouse effect, which is caused by greenhouse gases, which trap heat inside the Earth's atmosphere because of their more complex molecular structure which allows them to vibrate and in turn trap heat and release it back towards the Earth. This warming is also responsible for the extinction of natural habitats, which in turn leads to a reduction in wildlife population.The most recent report from the Intergovernmental Panel on Climate Change (the group of the leading climate scientists in the world) concluded that the earth will warm anywhere from 2.7 to almost 11 degrees Fahrenheit (1.5 to 6 degrees Celsius) between 1990 and 2100. What is an answer for this question: Which candidate will Mike not vote for?
Answer:
Jessica