You will be given a definition of a task first, then some input of the task.
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Paragraph: Introduction: Type-I interferons (IFNs) have been used to treat several types of cancers including follicular lymphoma, hairy cell leukemia and chronic myeloid leukemia. Treatment with type-I IFNs is however associated with significant toxic side effects due to the ubiquitous expression of type-I IFN receptors. Type-III IFNs elicit similar cellular responses as type-I IFNs, but restricted expression of type-III receptors may limit potential side effects of treatment with type-III IFNs. A number of studies are now exploring the use of type-III IFNs, specifically IFN-k3, as anticancer agents. IFN-k4 is a newly discovered type-III IFN that is genetically regulated and produced in a subset of individuals. Previously, we showed that IFN-k4 inhibits proliferation in a hepatoma cell line, however its anticancer potential has not been explored in comparison to other type-III IFNs. Methods: We developed stable human hepatoma (HepG2) and B-cell lymphoma (Raji) cell lines, engineered to express either IFN-k4-GFP or IFN-k3-GFP upon induction by doxycycline. We compared antiproliferative activity of IFN-k3 and IFN-k4 by measuring BRDU incorporation before and after induction of IFN-k expression. We also compared cell viability, apoptosis, and changes in cell cycle between IFN-k3 and IFN-k4 expressing cell lines. RNAseq and pathway analysis were used to explore the antiproliferative effect induced by IFN-k4. We show that IFN-k4 has higher antiproliferative activity compared to IFN-k3 in Raji and HepG2 cell lines and this can be explained by inhibition of the cell cycle. IFN-k4 expressing cell lines showed increased apoptotic cell death compared to IFN-k3 expressing cell lines. We also show that antiproliferative activity of IFN-k4 may be a result of inhibition of the MAPK pathway. Conclusion: This study demonstrates that IFN-k4 has a more potent antiproliferative activity than IFN-k3 in hepatoma and B cell lymphoma cell lines and the anticancer potential of IFN-k4 should be further explored. Introduction: Interleukin-1b (IL-1b) is a potent proinflammatory cytokine that is implicated both in acute and chronic viral infection. Persistent hepatic inflammation is the hallmark of hepatitis C virus (HCV) infection wherein it serves as a platform for progressive liver injury and onset of liver cancer. We examined the role of IL-1b role in HCV-induced hepatic inflammation by first assessing the transcriptional profile of chronic HCV patient liver by next-gen sequencing (RNAseq) staged by inflammation and fibrosis score. (microenvironment) role of IRF5 in mammary tumor initiation and progression.
Title: P001 IFN-K4 HAS A POTENT ANTIPROLIFERATIVE ACTIVITY IN B-CELL LYMPHOMA AND HEPATOMA CELL LINES HCV CORE PROTEIN TRIGGERS IL-1B PRODUCTION VIA THE NLRP3 INFLAMMASOME P004 LOSS OF IRF5 INDUCES SPONTANEOUS MAMMARY TUMORIGEN- ESIS P005 PROTEOLYTIC ORIGIN OF THE SOLUBLE HUMAN IL-6R IN VIVO AND A DECISIVE ROLE OF N-GLYCOSYLATION DISTINCT ROLES FOR IRF5 IN MAMMARY EPITHELIAL CELLS AND HOST TUMOR IMMUNITY: LOSS OF IRF5 IN EITHER COMPART- MENT LEADS TO TUMORIGENESIS SEXUALLY DIMORPHIC ROLES OF STAT3 IN PEDIATRIC BRAIN CANCER P008 DISRUPTION OF PD-1/PD-L1 SIGNALING IN 2D VS. 3D COLORECTAL CANCER COCULTURE MODEL REVEALED BY RNAI HIGH THROUGH- PUT SCREEN
Output:
False