Detailed Instructions: Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.
Problem:17-Hydroxysteroid dehydrogenases (17HSDs) are important enzymes regulating the pool of bioactive steroids in the breast. The current study was undertaken in order to evaluate implications of 17HSD14 in breast cancer, measuring 17HSD14 protein expression in breast tumours.', 'An antibody targeting the 17HSD14 antigen was generated and validated using HSD17B14-transfected cells and a peptide-neutralising assay. Tissue microarrays with tumours from 912 post-menopausal women diagnosed with lymph node-negative breast cancer, and randomised to adjuvant tamoxifen or no endocrine treatment, were analysed for 17HSD14 protein expression with immunohistochemistry.', 'Results were obtained from 847 tumours. Patients with oestrogen positive tumours with high 17HSD14 expression had fewer local recurrences when treated with tamoxifen (HR 0.38; 95% C.I. 0.19-0.77, p=0.007) compared to patients with lower tumoural 17HSD14 expression, for whom tamoxifen did not reduce the number of local recurrences (HR 1.19; 95% C.I. 0.54-2.59; p=0.66). No prognostic importance of 17HSD14 was seen for systemically untreated patients.
Solution:
0