Some context: John Craig Venter (born October 14, 1946) is an American biotechnologist, biochemist, geneticist, and businessman. He is known for being involved with sequencing the second human genome and assembled the first team to transfect a cell with a synthetic chromosome. Venter founded Celera Genomics, The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute (JCVI). He was the co-founder of Human Longevity Inc., served as its CEO until 2017, and is executive chairman of the board of directors.
On September 4, 2007, a team led by Sam Levy published the first complete (six-billion-letter) genome of an individual human--Venter's own DNA sequence. Some of the sequences in Venter's genome are associated with wet earwax, increased risk of antisocial behavior, Alzheimer's and cardiovascular diseases. This publication was especially interesting since it contained a diploid instead of a haploid genome and shows promise for personalized medicine via genotyping. This genome, dubbed HuRef by Levy and others, was a landmark accomplishment. The Human Reference Genome Browser is a web application for the navigation and analysis of Venter's recently published genome. The HuRef database consists of approximately 32 million DNA reads sequenced using microfluidic Sanger sequencing, assembled into 4,528 scaffolds and 4.1 million DNA variations identified by genome analysis. These variants include single-nucleotide polymorphisms (SNPs), block substitutions, short and large indels, and structural variations like insertions, deletions, inversions and copy number changes. The browser enables scientists to navigate the HuRef genome assembly and sequence variations, and to compare it with the NCBI human build 36 assembly in the context of the NCBI and Ensembl annotations. The browser provides a comparative view between NCBI and HuRef consensus sequences, the sequence multi-alignment of the HuRef assembly, Ensembl and dbSNP annotations, HuRef variants, and the underlying variant evidence and functional analysis. The interface also represents the haplotype blocks from which diploid genome sequence can be inferred and the relation of variants to gene annotations. The display of variants and gene annotations are linked to external public resources including dbSNP, Ensembl, Online Mendelian Inheritance in Man (OMIM) and Gene Ontology (GO). Users can search the HuRef genome using HUGO gene names, Ensembl and dbSNP identifiers, HuRef contig or scaffold locations, or NCBI chromosome locations. Users can then easily and quickly browse any genomic region via the simple and intuitive pan and zoom controls; furthermore, data relevant to specific loci can be exported for further analysis.
What are the HUGO gene names?
A: Users can search the HuRef genome using HUGO gene names, Ensembl and
Some context: Thomas Simpson (30 November 1937 - 13 July 1967) was one of Britain's most successful professional cyclists. He was born in Haswell, County Durham and later moved to Harworth, Nottinghamshire. Simpson began road cycling as a teenager before taking up track cycling, specialising in pursuit races. He won a bronze medal for track cycling at the 1956 Summer Olympics and a silver at the 1958 British Empire and Commonwealth Games.
Simpson was born on 30 November 1937 in Haswell, County Durham, the youngest of six children of coal miner Tom Simpson and his wife Alice (nee Cheetham). His father had been a semi-professional sprinter in athletics. The family lived modestly in a small terraced house until 1943, when his parents took charge of the village's working men's club and lived above it. In 1950 the Simpsons moved to Harworth on the Nottinghamshire-Yorkshire border, where young Simpson's maternal aunt lived; new coalfields were opening, with employment opportunities for him and older brother Harry, by now, the only children left at home. Simpson rode his first bike, his brother-in-law's, at age 12, sharing it with Harry and two cousins for time trials around Harworth. Following Harry, Tom joined Harworth & District CC (Cycling Club) aged 13. He delivered groceries in the Bassetlaw district by bicycle and traded with a customer for a better road bike. He was often left behind in club races; members of his cycling club nicknamed him "four-stone Coppi", after Italian rider Fausto Coppi, due to his slim physique. Simpson began winning club time trials, but sensed resentment of his boasting from senior members. He left Harworth & District and joined Rotherham's Scala Wheelers at the end of 1954. Simpson's first road race was as a junior at the Forest Recreation Ground in Nottingham. After leaving school he was an apprentice draughtsman at an engineering company in Retford, using the 10 mi (16.1 km) commute by bike as training. He placed well in half mile races on grass and cement, but decided to concentrate on road racing. In May 1955 Simpson won the National Cyclists' Union South Yorkshire individual pursuit track event as a junior; the same year, he won the British League of Racing Cyclists (BLRC) junior hill climb championship and placed third in the senior event. Simpson immersed himself in the world of cycling, writing letters asking for advice. Naturalised Austrian rider George Berger responded, travelling from London to Harworth to help him with his riding position. In late 1955, Simpson ran a red light in a race and was suspended from racing for six months by the BLRC. During his suspension he dabbled in motorcycle trials, nearly quitting cycling but unable to afford a new motorcycle necessary for progress in the sport.
Where did he go to school?
A:
Some context: William Hogarth was born at Bartholomew Close in London to Richard Hogarth, a poor Latin school teacher and textbook writer, and Anne Gibbons. In his youth he was apprenticed to the engraver Ellis Gamble in Leicester Fields, where he learned to engrave trade cards and similar products. Young Hogarth also took a lively interest in the street life of the metropolis and the London fairs, and amused himself by sketching the characters he saw. Around the same time, his father, who had opened an unsuccessful Latin-speaking coffee house at St John's Gate, was imprisoned for debt in Fleet Prison for five years.
In 1731 Hogarth completed the earliest of his series of moral works, a body of work that led to significant recognition. The collection of six scenes was entitled A Harlot's Progress and appeared first as paintings (now lost) before being published as engravings. A Harlot's Progress depicts the fate of a country girl who begins prostituting - the six scenes are chronological, starting with a meeting with a bawd and ending with a funeral ceremony that follows the character's death from venereal disease. The inaugural series was an immediate success and was followed in 1733-1735 by the sequel A Rake's Progress. The second instalment consisted of eight pictures that depicted the reckless life of Tom Rakewell, the son of a rich merchant, who spends all of his money on luxurious living, services from prostitutes, and gambling - the character's life ultimately ends in Bethlem Royal Hospital. The original paintings of A Harlot's Progress were destroyed in the fire at Fonthill House in 1755; the oil paintings of A Rake's Progress (1733-34) are displayed in the gallery room at Sir John Soane's Museum, London, UK. When the success of A Harlot's Progress and A Rake's Progress resulted in numerous pirated reproductions by unscrupulous printsellers, Hogarth lobbied in parliament for greater legal control over the reproduction of his and other artists' work. The result was the Engravers' Copyright Act (known as 'Hogarth's Act'), which became law on 25 June 1735 and was the first copyright law to deal with visual works as well as the first to recognize the authorial rights of an individual artist.
How many paintings were there in the Progress of Harlot ?
A:
six scenes are chronological,