Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Input: Consider Input: Paragraph: The trial results on patients with a gene anomaly known as NTRK fusion, which occurs in less than 1 percent across a range of tumor types, were presented at the annual congress of the European Society for Medical Oncology (ESMO) in Munich on Sunday. Germany's Bayer and U.S. partner Loxo, in turn, released data for their rival compound larotrectinib, which slightly improved on previous high-efficacy readings in an enlarged trial. Traditionally, oncologists have made treatment decisions based on where in the body a tumor started, increasingly helped by the growing knowledge of cancer's complex genetic drivers. Under the tumor-agnostic approach, also known as pan-tumor, drugmakers skip the organ-of-origin perspective and regroup patients based only on signature genetic mutations, but success in real life will depend on the fast spread of comprehensive gene-sequencing tools for tissue samples. Individually, the mutations are so rare that cancer units are seen as unlikely to run dedicated tests for each. Roche's Foundation Medicine supplies the comprehensive kits, competing with Thermo Fisher Scientific and Caris Life Sciences. "It's one of the reasons we acquired Foundation Medicine, to make this comprehensive genomic profiling routine and upfront in the course of the disease," said Daniel O'Day, the head of Roche's Pharmaceuticals division. Loxo's larotrectinib pill, co-developed with Bayer, was last year shown to shrink tumors in 75 percent of patients with the NTRK fusion gene anomaly, occurring in the lung, pancreas, or more than a dozen other organs. On Sunday, the response rate to larotrectinib within an enlarged group of 122 trial participants - up from 55 initially and now spanning 24 tumor types - was shown to be 81 percent. Roche said the readings from the two NTRK fusion trials were not comparable because they are made up of different patient types. Loxo's study, for instance, included some cancers in children, while Roche plans to investigate those separately. The Roche compound is designed to tackle several oncogenic mutations and last month, it unveiled data here on entrectinib pushing back tumors in 77 percent of lung cancer patients with a mutation called ROS1. Merck & Co's Keytruda in May last year became the first drug to win approval for pan-tumor use, though that remains a relatively small market for the mega-selling drug. Bayer and Loxo are testing a second pan-tumor drug, LOXO-195. Roche Pharmaceutical's O'Day welcomed a wider field. "Both things have to happen: You need genomic profiling and you need enough targeted medicines to encourage physicians to make that diagnosis upfront very complete. This is the world we're entering," he said. Though response rates could encourage a race for more such drugs, the need for suitable gene mutations or fusions will be a tall order, said oncologist Ulrik Lassen of Copenhagen's Rigshospitalet, who co-authored the larotrectinib study. "You need to screen a lot of patients to find the needle in the haystack and the method is complicated, costly and time-consuming. When we get better at using these technologies, we can find more oncogenic fusions and companies will be smart enough to find the agents that target them." Roche acquired entrectinib as part of its takeover deal with U.S. cancer drug specialist Ignyta Inc for $1.7 billion, agreed in December last year. Immuno-oncology remains another major business area for Roche, which also released positive results on using its Tecentriq drug in a group of breast cancer patients with a particularly poor prognosis. Claim: Roche takes on Loxo, Bayer in gene-defined cancer class.

Output: Roche's entrectinib cancer pill was shown to shrink tumors in 57 percent of patients within a group that can only be identified via genetic profiling, as the Swiss drugmaker challenges an alliance of Bayer and Loxo Oncology in a new targeted treatment area.

Input: Consider Input: Paragraph: The power crisis is affecting health and sanitation - because sewage treatment plants can't run, raw sewage is pouring into the Mediterranean - and now the elderly and sick are desperately trying to handle the heat. Plastic trays and scraps of cardboard are doubling as hand-held fans. Precious piped water is hosed over children and work animals. Those trying to sleep have abandoned clammy mattresses, preferring the relative cool of bare tiled floors. Hoping to pressure the Islamist Hamas group to relinquish control of Gaza, Palestinian President Mahmoud Abbas has reduced his administration's payments to Israel for the electricity it supplies to Gaza. That has left the 2 million Palestinians there with only a few hours of power a day. Hospitals and other emergency facilities have made do with back-up generators. Few ordinary Palestinians have that option. A family excursion to the beach that might elsewhere have been a delight was, for Sabah Joudah, a forced decision, especially when having to put up with the sewage problems. "We came here to entertain the children, even though the sea is polluted," she told Reuters as the dirty surf lapped close by. "It is summer and there is no electricity; no water and no fans are working in our homes. It is very tough, very tough." Environment officials say disruptions at sewage treatment facilities have meant more than 100,000 liters of untreated wastewater is discharged along the coast daily. Around 75 percent of the seawater is polluted. Swimming there frequently leaves children with skin inflammations and abdominal complaints, parents say. In the southern town of Khan Younis, a woman bathed her children in a bucket in the street, while a man doused his horse with water. One Khan Younis couple, the Abu Mehsens, both suffer from high blood pressure and said they were so beleaguered by the heat that simply fanning themselves could be too much effort. "When we get tired we rest for a bit before we start fanning again," Jihan Abu Mehsen said. "We do so all day long." The situation has hurt Gaza's meager retail sector, with vendors saying that sales of electrical appliances have tanked. One exception has been cheap rechargeable fans, which can be stored, with full batteries, in anticipation of the power cuts. "People have turned to alternative power, using batteries," said appliance salesman Mahmoud Abu Hamda. "Sometimes they use trays and sometimes even the covers of kettles instead of electric fans. This has impacted us very much." Claim: As temperatures soar, desperate Gazans try any means to beat heat.

Output: As Middle East summer temperatures soar above 35 degrees Celsius (95 Fahrenheit), Gazans are struggling to stay cool amid a power crisis, with less than four hours of electricity a day and little chance to run fans and air-conditioners.

Input: Consider Input: Paragraph: On March 21 2020, Facebook and Twitter users began sharing purportedly official guidelines for COVID-19 and sex, attributed to the New York City Health Department:the NYC department of health says that during the COVID-19 pandemic "you are your safest sex partner", so i'm just trying to spread the word pic.twitter.com/oUHIqRKlfY Tommy Siegel (@TommySiegel) March 23, 2020OMG I had a mouthful of ass while reading this NYC Health guide to Covid-safe Sex and of course, responsible New Yorker that I am, I IMMEDIATELY spat it out. Is there a five second rule? #oneonethousandtwoonethousand pic.twitter.com/QpDmt4hJU0 BD WONG (@wongbd) March 23, 2020Highlights of NYC's government official guide to having safe sex during these times include:-"wash your hands (and any sex toys)"-Rimming (mouth on anus) might spread COVID-19."-"You are your safest sex partner." pic.twitter.com/M0VzSVP75I chris (@ichrisherrero) March 22, 2020The NYC Health Department's guide to sex during the COVID-19 outbreak is a gem. https://t.co/pX3nrHzrjv Sasha Perigo (@sashaperigo) March 21, 2020Facebook's iterations of the share bore the NYC Health logo, but typically linked to a Google Docs PDF with no clear attribution. That document was unassumingly titled "covid-sex-guidance.pdf," and it began by urging all New York City residents to stay home in an effort to reduce the spread of highly infectious coronavirus strain COVID-19.Immediately thereafter, it addressed whether it was safe to have sex at all while coronavirus was spreading:Sex and Coronavirus Disease 2019 (COVID-19)All New Yorkers should stay home and minimize contact with others to reduce the spread of COVID-19.But can you have sex? Here are some tips for how to enjoy sex and to avoid spreading COVID-19.1. Know how COVID-19 spreads. You can get COVID-19 from a person who has it. o The virus can spread to people who are within about 6 feet of a person with COVID-19 when that person coughs or sneezes. o The virus can spread through direct contact with their saliva or mucus. We still have a lot to learn about COVID-19 and sex. o COVID-19 has been found in feces of people who are infected with the virus. o COVID-19 has not yet been found in semen or vaginal fluid. o We know that other coronaviruses do not efficiently transmit through sex.Amorous New York City residents were first advised to understand how coronavirus COVID-19 spreads, and detailed how as of March 2020 still in the first weeks of a global pandemic comparatively little is still known about about SARS-nCoV-2. In the document's second point, it went on to provide perhaps the most discussed of all the advice on the page (emphasis ours):2. Have sex with people close to you. You are your safest sex partner. Masturbation will not spread COVID-19, especially if youwash your hands (and any sex toys) with soap and water for at least 20 seconds beforeand after sex. The next safest partner is someone you live with. Having close contact including sex with only a small circle of people helps prevent spreading COVID-19. You should avoid close contact including sex with anyone outside your household. If you do have sex with others, have as few partners as possible and avoid group sex. If you usually meet your sex partners online or make a living by having sex, consider taking a break from in-person dates. Video dates, sexting or chat rooms may be options for you.City residents were, to put it bluntly, advised to stay home and masturbate. However, if that wasn't sufficiently stimulating, household members were deemed the safest option with whom to have sex.Group sex was, perhaps predictably, not recommended during the pandemic.While Facebook shares linked to a Google Docs page, tweets about the NYC guidelines for safe sex and COVID-19 tended to be in screenshot form. It was uncommon to see anything with a direct link back to an official, verified NYC.gov account. We checked the official NYC Department of Health Facebook page and did not see the COVID-19 sex guidelines shared there.Twitter was another story, though:Soooo Since we're all staying home, you might be wondering what to do with all that extra time. We got you, NYC. 😘Read our guide on how to enjoy sex and avoid spreading #COVID19: https://t.co/fjjkfGgf3C nycHealthy STAY HOME NYC (@nycHealthy) March 22, 2020In addition to a link to a NYC.gov page, the tweet read:Soooo Since we're all staying home, you might be wondering what to do with all that extra time. We got you, NYC. 😘Read our guide on how to enjoy sex and avoid spreading #COVID19: https://on.nyc.gov/3agKh8ULinked was the same circulating document [PDF], with "covid-sex-guidance.pdf" and "Sex and Coronavirus Disease 2019 (COVID-19)" as titles. The officially issued guidance matched the aforementioned screengrabs and documents, right down to "you are your safest sex partner" and "masturbation will not spread COVID-19." The circulating document is authentic despite the fact it s spreading primarily via screenshots or an unattributed Google Docs page. Claim: New York City Health (NYC Health) issued official guidelines for sex during a global coronavirus pandemic.
Output: Did the NYC Department of Health Issue 'COVID-19 Sex' Guidelines?