Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: It has been reported that the R497K polymorphism of the epidermal growth factor receptor (EGFR) gene has attenuated functions in ligand binding, tyrosine kinase activation, and growth stimulation. On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib. We investigated the EGFR mutations and/or R497K polymorphism statuses in 225 surgically treated NSCLC cases. 192 adenocarcinoma cases were included. The presence or absence of EGFR polymorphism of exon 13 was analyzed by PCR-RFLP method. EGFR mutations at kinase domain were found from 95 of 225 lung cancer patients. In 86.2% of patients, homo- or heterozygous Lys497 allele was present. No correlation existed between R497K EGFR genotype and clinico-pathological features, such as gender, smoking status, and pathological subtypes. EGFR mutation status was not correlated with R497KEGFR genotype of lung cancers. In node-negative patients, R497KEGFR genotype was not correlated with disease outcome. In node-positive patients, however, R497K EGFR was significantly associated with better overall survival. This association was attributable to neo-adjuvant or adjuvant chemotherapy. In 46 total gefitinib treated NSCLC patients, the prognosis was not different between the EGFR wild type (GG) patients and AG+AA patients. R497KEGFR polymorphism might be associated with favorable prognosis of advanced lung cancers and correlated with chemosensitivity.

Answer: Mutations in which gene determine response to both erlotinib and gefitinib?

Question: D0g is a fictional character in the Half-Life series of video games, first introduced in Half-Life 2 in 2004.

Answer: What fictional work does D0g exist in?

Question: One day Mr. White gave his wife ten pounds for her birthday -- ten new pound notes. So Mrs. White went out shopping. She waited for a bus, got on it and sat down next to an o1d 1ady. After a while, Mrs. White noticed that the old 1ady's handbag was open. Inside it, she saw a wad of pound notes exactly like the ones her husband had given her. So she quickly looked into her own bag -- the notes had gone! Mrs. White was sure that the o1d lady next to her had stolen them. She immediately thought of calling the police. But as she disliked making a fuss , she decided to take back the money from the old 1ady's hand bag and say nothing about it. She looked around to make sure nobody was watching. Then she carefully put her hand into the o1d lady's bag, took the notes, and put them into her own handbag. When she got home that evening, Mrs. White showed her husband the beautiful hat she had bought. "How did you pay for it?" Mr. White asked. "With the money you gave me for my birthday, of course" she answered. "Oh? What's that, then?" he asked, as he pointed to a wad of pound notes on the table.

Answer:
Why did Mr. White give his wife ten pounds?