In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: A dyslipidemia with phenotype IIa of Fredrickson may have its origin in mutations in the gene of:
Options: <1> The LDL receptor. <2> Lipoprotein lipase (LPL). <3> The Apo CII. <4> The Apo A-II. <5> The Apo B-48.
1