The majority of eukaryotic genes are stored on a set of large, linear chromosomes. The chromosomes are packed within the nucleus in complex with storage proteins called histones to form a unit called a nucleosome. DNA packaged and condensed in this way is called chromatin.:4.2 The manner in which DNA is stored on the histones, as well as chemical modifications of the histone itself, regulate whether a particular region of DNA is accessible for gene expression. In addition to genes, eukaryotic chromosomes contain sequences involved in ensuring that the DNA is copied without degradation of end regions and sorted into daughter cells during cell division: replication origins, telomeres and the centromere.:4.2 Replication origins are the sequence regions where DNA replication is initiated to make two copies of the chromosome. Telomeres are long stretches of repetitive sequence that cap the ends of the linear chromosomes and prevent degradation of coding and regulatory regions during DNA replication. The length of the telomeres decreases each time the genome is replicated and has been implicated in the aging process. The centromere is required for binding spindle fibres to separate sister chromatids into daughter cells during cell division.:18.2
What does the manner of DNA storage on the histone and the chemical modifications of the histone itself regulate?
whether a particular region of DNA is accessible for gene expression

Input: Middle Ages
Depopulation, deurbanisation, invasion, and movement of peoples, which had begun in Late Antiquity, continued in the Early Middle Ages. The barbarian invaders, including various Germanic peoples, formed new kingdoms in what remained of the Western Roman Empire. In the 7th century, North Africa and the Middle Eastonce part of the Eastern Roman Empirecame under the rule of the Caliphate, an Islamic empire, after conquest by Muhammad's successors. Although there were substantial changes in society and political structures, the break with Antiquity was not complete. The still-sizeable Byzantine Empire survived in the east and remained a major power. The empire's law code, the Code of Justinian, was rediscovered in Northern Italy in 1070 and became widely admired later in the Middle Ages. In the West, most kingdoms incorporated the few extant Roman institutions. Monasteries were founded as campaigns to Christianise pagan Europe continued. The Franks, under the Carolingian dynasty, briefly established the Carolingian Empire during the later 8th and early 9th century. It covered much of Western Europe, but later succumbed to the pressures of internal civil wars combined with external invasionsVikings from the north, Magyars from the east, and Saracens from the south.

In what year did Italians discover the Code of Justinian?
Output: 1070

Input: Article: In 1981, the MUSE system was demonstrated for the first time in the United States, using the same 5:3 aspect ratio as the Japanese system. Upon visiting a demonstration of MUSE in Washington, US President Ronald Reagan was impressed and officially declared it "a matter of national interest" to introduce HDTV to the US.

Now answer this question: Which system was demonstrated in Washington to President Ronald Reagan?

Output: MUSE

Article: Although not yet tested as a therapy in humans, a growing body of evidence indicates that zinc may preferentially kill prostate cancer cells. Because zinc naturally homes to the prostate and because the prostate is accessible with relatively non-invasive procedures, its potential as a chemotherapeutic agent in this type of cancer has shown promise. However, other studies have demonstrated that chronic use of zinc supplements in excess of the recommended dosage may actually increase the chance of developing prostate cancer, also likely due to the natural buildup of this heavy metal in the prostate.

Question: What could overuse of zinc possibly cause?
Ans: prostate cancer

Here is a question about this article: The Bengali Renaissance refers to a social reform movement during the nineteenth and early twentieth centuries in the Bengal region of India during the period of British rule dominated by English educated Bengali Hindus. The Bengal Renaissance can be said to have started with Raja Ram Mohan Roy (17721833) and ended with Rabindranath Tagore (18611941), although many stalwarts thereafter continued to embody particular aspects of the unique intellectual and creative output of the region. Nineteenth century Bengal was a unique blend of religious and social reformers, scholars, literary giants, journalists, patriotic orators, and scientists, all merging to form the image of a renaissance, and marked the transition from the 'medieval' to the 'modern'.
What is the answer to this question: What group lead the Bengali Renaissance?
****
So... English educated Bengali Hindus

Article: The National Archives Building in downtown Washington holds record collections such as all existing federal census records, ships' passenger lists, military unit records from the American Revolution to the PhilippineAmerican War, records of the Confederate government, the Freedmen's Bureau records, and pension and land records.

Question: What's the latest war The National Archives Building has military unit records for?
Ans:
PhilippineAmerican War