In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Input: Consider Input: Question: When comparing the characteristics of pragmatic or confirmatory clinical studies with explanatory or exploratory clinical studies, which of the following is an advantage of the former?
Options: <1> Information about subgroups of patients representative of the usual clinical practice. <2> Very homogeneous sample, with little variability. <3> Greater capacity to detect differences in the effectiveness of interventions. <4> Greater internal validity <5> Smaller sample size

Output: 1

Input: Consider Input: Question: A 55-year-old woman with adrenal insufficiency has been prescribed corticosteroid treatment. Which of the following instructions would you provide in relation to this treatment?
Options: <1> Take the drug first thing in the morning. <2> Take the drug before bedtime. <3> Exclude foods rich in calcium and vitamin D from the diet. <4> Eat a diet low in calories and protein. <5> Monitor the decrease in blood pressure.

Output: 1

Input: Consider Input: Question: The lithium aluminum hydride is a nucleophile strong enough to be added to the carbonyl group of the carboxylate ions. This process allows obtaining:
Options: <1> Primary alcohols. <2> Secondary alcohols <3> Tertiary alcohols. <4> Ketones <5> Ethers
Output: 1