Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

[EX Q]: Abstract: The binding by serum albumin of many drugs and endogenous metabolites is impaired in humans and animals with renal failure. Unknown solute(s) retained in renal failure have been extracted from uremic fluids. When added to normal plasma they induce a similar binding defect. Similar activity can be extracted from normal urine. We have devised a series of extraction and purification techniques that yielded three binding inhibitory ligands from normal human urine in sufficient quantity and of a high degree of purity. Rigorous methods have been applied to determine chemical identity of the ligands. Purification steps consisted of: adsorption at pH 3.0 to polystyrene-divinylbenzene resin (XAD-2); elution from the resin with methanol followed by drying and solution in dilute formic acid; passage through SP-Sephadex to remove cations, especially yellow-brown pigments; adsorption to the anion exchanger QAE-Sephadex, and separation into three zones of inhibitory activity with a formic acid gradient; purification to homogeneity with C-8 or C-18 silica reversed-phase chromatography. Using this isolation procedure, followed by mass spectroscopy and nuclear magnetic resonance spectroscopy, we have shown that the binding inhibitory activity is due not to one ligand, but to a family of aromatic acids. To date hippurate, beta-(m-hydroxyphenyl)-hydracrylate and p-hydroxyphenylacetate have been identified as binding inhibitors. Other active ligands remain to be identified.
Which is the apt title for the abstract? option1: Isolation and chemical identification of inhibitors of plasma ligand binding. option2: Benign acute childhood myositis: an unusual cause of refusal to walk.
[EX A]: Isolation and chemical identification of inhibitors of plasma ligand binding.

[EX Q]: Abstract: Seventy-seven samples of healthy and diseased vulvar epithelium (one per patient) were processed using the carbon-coated-dextran biochemical technique. The results were analyzed according to Scatchard or the unique point technique. The samples of normal tissue were obtained from patients who underwent surgical procedures for different gynecologic pathologies. The samples of diseased tissue were obtained with punch biopsy from patients with several vulvar disorders. Ten samples were obtained from the episiotomy wound in pregnant patients during labor. Estrogen receptors were assayed in all cases. Progesterone receptors were assayed simultaneously in 73 of the cases. The minimum concentration considered positive was 2 fmol/mg of protein. A map of the vulvar region was drawn, and samples were obtained from different sites whenever possible.
Which is the apt title for the abstract? option1: Estrogen and progesterone receptor assays on the vulvar epithelium. option2: Topical application of colchicine, vinblastine and vincristine prevents strychnine-enhanced transsynaptic degeneration in the medullary dorsal horn following transection of the inferior alveolar nerve in adult rats.
[EX A]: Estrogen and progesterone receptor assays on the vulvar epithelium.

[EX Q]: Abstract: A 17-year-old girl had a multicentric giant cell tumor originating in the sphenoid and sella turcica that was observed for 23 years. During the first 12 years, the same lesion also appeared in the right proximal tibia and left distal radius. Curettage of the tibial lesion and packing with processed bovine bone were followed by a chronic osteomyelitis with continued intermittent wound drainage. Curettage of the radial lesion and packing it initially with autogenous iliac bone graft and subsequently with methylmethacrylate bone cement were followed by local recurrences. The radial lesion eventually was eradicated by a segmental resection of the distal radius. The resulting bony defect was bridged with a bicortical autogenous iliac graft and stabilized with a bone plate to produce a painless solid wrist fusion. No further tumor recurrence has been noted for the past two years.
Which is the apt title for the abstract? option1: Evolution of a case of multicentric giant cell tumor over a 23-year period. option2: Free radicals and prostanoid synthesis [editorial]
[EX A]:
Evolution of a case of multicentric giant cell tumor over a 23-year period.