instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: The consumption of diet-based naturally bioactive metabolites is preferred to synthetic material in order to avert health-associated disorders. Among the plant-derived polyphenols, kaempferol (KMF) is considered as a valuable functional food ingredient with a broad range of therapeutic applications such as anti-cancer, antioxidant and anti-inflammatory uses. KMF acts on a range of intracellular as well as extracellular targets involved in the cell signaling pathways that in turn are known to regulate the hallmarks of cancer growth progressions like apoptosis, cell cycle, invasion or metastasis, angiogenesis and inflammation. Importantly, the understanding of mechanisms of action of KMF-mediated therapeutic effects may help the scientific community to design novel strategies for the treatment of dreadful diseases. The current review summarizes the various types of molecular targets of KMF in cancer cells as well as other health-associated disorders. In addition, this review also highlights the absorption, metabolism and epidemiological findings.
Title: Kaempferol -A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements
answer:
True

question:
Paragraph: While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates that some picornaviruses hijack autophagy in order to induce autophagosome-like membrane structures for genomic RNA replication. Expression of picornavirus proteins can specifically induce the machinery of autophagy, although the mechanisms by which the viruses employ autophagy appear to differ. Many picornaviruses up-regulate autophagy in order to promote viral replication while some members of the family also inhibit degradation by autolysosomes. Here we explore the unusual relationship of this medically important family of viruses with a degradative mechanism of innate immunity.
Title: Picornavirus Subversion of the Autophagy Pathway
answer:
True

question:
Paragraph: Nerve growth factor (NGF) is overexpressed in patients with inflammatory lung diseases, including virus infections. Airway surface liquid (ASL), which is regulated by epithelial cell ion transport, is essential for normal lung function. No information is available regarding the effect of NGF on ion transport of airway epithelium. To investigate whether NGF can affect ion transport, human primary air-interface cultured epithelial cells were placed in Ussing chambers to obtain transepithelial voltage (A7.1 AE 3.4 mV), short-circuit current (I sc , 5.9 AE 1.0 lA), and transepithelial resistance (750 OAcm 2 ), and to measure responses to ion transport inhibitors. Amiloride (apical, 3.5 9 10 A5 mol/L) decreased I sc by 55.3%. Apically applied NGF (1 ng/mL) reduced I sc by 5.3% in 5 min; basolaterally applied NGF had no effect. The response to amiloride was reduced (41.6%) in the presence of NGF. K-252a (10 nmol/ L, apical) did not itself affect Na + transport, but it attenuated the NGFinduced reduction in Na + transport, indicating the participation of the trkA receptor in the NGF-induced reduction in Na + transport. PD-98059 (30 lmol/L, apical and basolateral) did not itself affect Na + transport, but attenuated the NGF-induced reduction in Na + transport, indicating that trkA activated the Erk 1/2 signaling cascade. NGF stimulated phosphorylation of Erk 1/2 and the b-subunit of ENaC. K-252a and PD-98059 inhibited these responses. NGF had no effect on I sc in the presence of apical nystatin (50 lmol/L). These results indicate that NGF inhibits Na + transport through a trkA-Erk 1/2-activated signaling pathway linked to ENaC phosphorylation.
Title: Nerve growth factor reduces amiloride-sensitive Na + transport in human airway epithelial cells
answer:
True