instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does variation in the gene for human peroxisome proliferator activated receptor gamma ( PPARgamma ) play a major role in the development of morbid obesity?
Answer: Variation in the PPARgamma gene is unlikely to play a major role in the development of morbid obesity.
answer:
no

question:
Question: Does protamine affect the formation of cGMP or cAMP in pig vascular smooth muscle cells in response to vasodilators?
Answer: These experiments show that protamine does not alter the responses of the intracellular second messengers, cGMP and cAMP, to the vasodilators sodium nitroprusside, atrial natriuretic peptide, isoproterenol, and forskolin. These results do not support the hypothesis that protamine sensitizes vascular smooth muscle cells to the endothelium-derived relaxing factor, nitric oxide.
answer:
no

question:
Question: Does the pro-apoptotic K-Ras 4A proto-oncoprotein affect tumorigenesis in the ApcMin/+ mouse small intestine?
Answer: The K-Ras 4A proto-oncoprotein does not exhibit tumour suppressor activity in the small intestine, even though the K-ras 4A/4B ratio is reduced in adenomas lacking K-ras activating mutations.
answer:
no