Instructions: Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
Input: The release, while loaded with information about the research, fails to mention costs related to this new approach at any point. This is in spite of the fact that the paper provides what's necessaryto fulfill this criterion. The study authors wrote: "The easy access to the tumor site, the absence of the need for surgical removal of the tissue containing the T cells, the numbers of cells obtained with the harvest, and the ability to expand products in all patients with a relatively short process at a reasonable cost contrast sharply with several limitations of TIL ACT" (a current therapeutic approach to the disease). The release does a good job of spelling out the results of this phase1 trial by providing data showing that MILs can target and kill cancer cells. It shows that in more than half of the study's patients, their cancers had shrunk by at least half. In 15 of the 22 patients, their cancers did not progress for nearly a year after the MILs therapy. This wasn't a controlled study, so it's unclear how these patients would have fared without the MILs treatment, and the release could have attempted to provide some insight on that point. But we're pleased that the release focuses appropriately on the apparent safety of the approach, rather than trying to make claims about survival benefits that aren't supportable by this kind of small, uncontrolled study. The release also explains that the research provides information suggesting which patients might benefit best from this approach, and that other research at this cancer center is centered on testing this approach on different forms of cancer. We'll give this criterion a satisfactory rating since the release specifically spells out, "None of the participants had serious side effects from the MILs therapy." However, the study is really too small, and the timespan too short, to comment substantively on the possible harms that might be seen if and when the treatment is more widely used. The research paper actually makes the point that the new procedure doesn't require the "surgical removal of tissue," and the procedure can be done at bedside rather than an operating suite. Butthe removal of cells from the bone marrow is still an invasive procedure that carries its own risk of infection or other problems. The release would have benefited from at least mentioning this aspect. The release makes a very good effort to objectively describe a technically complicated trial. It defines the trial at least twice as being "small" and calls it a "pilot," suggesting that caution is appropriate when considering the results. It effectively explains the process involved in the treatments, including what was learned regarding the growth of cells in the lab after harvesting. It also points to the fact that while tumor-infiltrating lymphocytes (TILs) can only be retrieved from a quarter of the patient candidates for this technique, MILs were obtained from all of the patients in this study, suggesting that they may be a better tool for this therapy. Describing multiple myeloma as "the second most common cancer originating in the blood" doesn't add much to our understanding of this disease. However, other statistics provide context regarding the scope of the problem in the United States. We'll give it a pass. The funding sources for this research are listed in an end note in the release. No conflict of interest information is provided in the release, although the research paper discloses no conflicts. The release does mention that other forms of this adoptive T cell therapy use different cells, suggesting that other approaches are possible. The release also notes, "Three days before the injections of expanded MILs, patients received high doses of chemotherapy and a stem cell transplant, standard treatments for multiple myeloma." The release points out that "several U.S. cancer centers have conducted similar experimental treatments" but adds that Johns Hopkins is the only one using the MIL cells. It also points to several other ongoing clinical trials at Hopkins that build on the findings of this small study. Using the terms "pilot" and "experimental," the release signals that availability is very limited. We like the fact that the headline itself defines this as a "pilot" clinical trial and that the lede says that it is "what is believed to be the first small clinical trial of its kind." Those kinds of qualifiers both declare the specifics of the research and also provide informative caveats, allowing the reader to gauge how much credence to give to the findings. All too many other medical releases fail to provide this measured approach. This release is conservative throughout in its choice of language in describing this research which, based on its findings, might be ripe for exaggeration.
Output:
Pilot clinical trial finds injected immune cells safe in multiple myeloma patients