TASK DEFINITION: In this task, you are given the abstract of a research paper. Your task is to generate a summary of this abstract. Your summary should not be very short, but it's better if it's not more than 30 words.
PROBLEM: Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drugs applied at different dosages can be quantified. The general approach is to find a function mapping the images to an embedding space of manageable dimensionality whose geometry captures relevant features of the input images. An important known issue for such methods is separating relevant biological signal from nuisance variation. For example, the embedding vectors tend to be more correlated for cells that were cultured and imaged during the same week than for cells from a different week, despite having identical drug compounds applied in both cases. In this case, the particular batch a set of experiments were conducted in constitutes the domain of the data; an ideal set of image embeddings should contain only the relevant biological information (e.g. drug effects). We develop a general framework for adjusting the image embeddings in order to 'forget' domain-specific information while preserving relevant biological information. To do this, we minimize a loss function based on distances between marginal distributions (such as the Wasserstein distance) of embeddings across domains for each replicated treatment. For the dataset presented, the replicated treatment is the negative control. We find that for our transformed embeddings (1) the underlying geometric structure is not only preserved but the embeddings also carry improved biological signal (2) less domain-specific information is present.

SOLUTION: We correct nuisance variation for image embeddings across different domains, preserving only relevant information.

PROBLEM: As the basic building block of Convolutional Neural Networks (CNNs), the convolutional layer is designed to extract local patterns and lacks the ability to model global context in its nature. Many efforts have been recently made to complement CNNs with the global modeling ability, especially by a family of works on global feature interaction. In these works, the global context information is incorporated into local features before they are fed into convolutional layers. However, research on neuroscience reveals that, besides influences changing the inputs to our neurons, the neurons' ability of modifying their functions dynamically according to context is essential for perceptual tasks, which has been overlooked in most of CNNs. Motivated by this, we propose one novel Context-Gated Convolution (CGC) to explicitly modify the weights of convolutional layers adaptively under the guidance of global context. As such, being aware of the global context, the modulated convolution kernel of our proposed CGC can better extract representative local patterns and compose discriminative features. Moreover, our proposed CGC is lightweight, amenable to modern CNN architectures, and consistently improves the performance of CNNs according to extensive experiments on image classification, action recognition, and machine translation.

SOLUTION: A novel Context-Gated Convolution which incorporates global context information into CNNs by explicitly modulating convolution kernels, and thus captures more representative local patterns and extract discriminative features.

PROBLEM: Disentangling factors of variation has always been a challenging problem in representation learning. Existing algorithms suffer from many limitations, such as unpredictable disentangling factors, bad quality of generated images from encodings, lack of identity information, etc. In this paper, we proposed a supervised algorithm called DNA-GAN trying to disentangle different attributes of images. The latent representations of images are DNA-like, in which each individual piece represents an independent factor of variation. By annihilating the recessive piece and swapping a certain piece of two latent representations, we obtain another two different representations which could be decoded into images. In order to obtain realistic images and also disentangled representations, we introduced the discriminator for adversarial training. Experiments on Multi-PIE and CelebA datasets demonstrate the effectiveness of our method and the advantage of overcoming limitations existing in other methods.

SOLUTION:
We proposed a supervised algorithm, DNA-GAN, to disentangle multiple attributes of images.