Read the text and answer the questions.

By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.

1. Who isolated epinephrine?
2. Was it pure?
3. What form was it
4. Did someone produce it in a pure state?
5. Who?
6. What was it used for?
7. How was it used?
8. Was there another way it was administered?
9. How?
10. What was the brand name?
11. When could someone buy it in the US?
12. Who else offered the drug?
13. What was it called?
14. What else was epinephrine used to treat?
15. Starting when?
16. What did people want to learn more about?
17. Of what chemicals?
18. Why?
19. What did they want to make?
20. What was an early usage of the chemicals?
1. John Abel
2. no
3. in an impure state
4. yes
5. Jokichi Takamine
6. for the acute treatment of asthma attacks
7. it was injected
8. yes
9. inhaled
10. Primatene Mis
11. until 2011
12. Parke Davis
13. Adrenalin
14. nasal congestion
15. 1929
16. the mechanism of chemical signalling
17. adrenal extracts
18. they had a profound effect on many different tissue types
19. new drugs
20. blood pressure raising and vasoconstrictive effects