Instructions: In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
Input: Paragraph: We have synthesized and characterized a series of compounds containing the 3azatetracyclo[5.2.1.1 5,8 .0 1,5 ]undecane scaffold designed as analogs of amantadine, an inhibitor of the M2 proton channel of influenza A virus. Inhibition of the wild-type (wt) M2 channel and the amantadine-resistant A/M2-S31N and A/M2-V27A mutant ion channels were measured in Xenopus oocytes using two-electrode voltage clamp (TEV) assays. Most of the novel compounds inhibited the wt ion channel in the low micromolar range. Of note, several compounds inhibited the A/M2 V27A mutant ion channel, one of them with submicromolar IC 50 . None of the compounds was found to inhibit the S31N mutant ion channel. The antiviral activity of three novel dual wt and A/M2-V27A channels inhibitors was confirmed by influenza virus yield assays. Amantadine; cage compounds; influenza A virus; M2 proton channel; drug design c MCC: minimum cytotoxic concentration, or concentration producing minimal alterations in cell morphology after 72 hr incubation with compound. d CC 50 : 50% cytotoxic concentration, as determined by the MTS cell viability test. Values shown are the mean of 2-3 determinations. J Med Chem.
Title: 3-Azatetracyclo[5.2.1.1 5,8 .0 1,5 ]undecane derivatives: from wild- type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant NIH Public Access
Output:
True