Question: Question: "What must be done before phases start?" Context: "In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted." Answer:
Answer: sufficient pre-clinical data to support proceeding with human trials

[Q]: Question: "What are some of the hotels in Nepal that come after the luxury hotels?" Context: "With the opening of the tourist industry after the change in the political scenario of Nepal in 1950, the hotel industry drastically improved. Now Kathmandu boasts several luxury such as the Hyatt Regency, Dwarika's, theYak & Yeti, The Everest Hotel, Hotel Radisson, Hotel De L'Annapurna, The Malla Hotel, Shangri-La Hotel (which is not operated by the Shangri-La Hotel Group) and The Shanker Hotel. There are several four-star hotels such as Hotel Vaishali, Hotel Narayani, The Blue Star and Grand Hotel. The Garden Hotel, Hotel Ambassador, and Aloha Inn are among the three-star hotels in Kathmandu. Hotels like Hyatt Regency, De L'Annapurna and Hotel Yak & Yeti are among the five-star hotels providing casinos as well." Answer:
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[A]: Hotel Vaishali, Hotel Narayani, The Blue Star and Grand Hotel

input: Please answer the following: Question: "Where was Patasse when Bozize successfully overthrew him?" Context: "In the aftermath of the failed coup, militias loyal to Patasse sought revenge against rebels in many neighborhoods of Bangui and incited unrest including the murder of many political opponents. Eventually, Patasse came to suspect that General Francois Bozize was involved in another coup attempt against him, which led Bozize to flee with loyal troops to Chad. In March 2003, Bozize launched a surprise attack against Patasse, who was out of the country. Libyan troops and some 1,000 soldiers of Bemba's Congolese rebel organization failed to stop the rebels and Bozize's forces succeeded in overthrowing Patasse.[citation needed]" Answer:
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output: out of the country

Please answer this: Question: "What is notable about the Roman Empire?" Context: "The Roman Empire came to dominate the entire Mediterranean basin in a vast empire based on Roman law and Roman legions. It promoted trade, tolerance, and Greek culture. By 300 AD the Roman Empire was divided into the Western Roman Empire based in Rome, and the Eastern Roman Empire based in Constantinople. The attacks of the Germanic peoples of northern Europe led to the Fall of the Western Roman Empire in AD 476, a date which traditionally marks the end of the classical period and the start of the Middle Ages." Answer:
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Answer: The Roman Empire came to dominate the entire Mediterranean basin in a vast empire

Problem: Question: "If a country has a higher HDI than another country, but the life expectancy of their inhabitants and time spent in education is similar, what is it likely due to?" Context: "The Human Development Index (HDI) is a composite statistic of life expectancy, education, and income per capita indicators, which are used to rank countries into four tiers of human development. A country scores higher HDI when the life expectancy at birth is longer, the education period is longer, and the income per capita is higher. The HDI was developed by the Pakistani economist Mahbub ul Haq, often framed in terms of whether people are able to "be" and "do" desirable things in their life, and was published by the United Nations Development Programme." Answer:

A: income per capita

input: Please answer the following: Question: "Due to the company's announcement, who was the one who could generate abuse?" Context: "In October 2013, the company announced the "Save a Page" feature which allows any Internet user to archive the contents of a URL. This became a threat of abuse by the service for hosting malicious binaries." Answer:
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output:
the service