TASK DEFINITION: Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).
PROBLEM: Abstract: This report reviews 833 patients who underwent internal mammary artery grafting alone or with vein grafts between 1968 and 1981. Use of the internal mammary artery was indicated in young or middle-aged patients with the following characteristics: a significant lesion of the proximal left anterior descending artery or its diagonal branch alone (70.1%) or combined with diffuse atherosclerosis (19.9%) or a small caliber (3.4%); absent or unsuitable veins for grafting (5.5%); atherosclerosis or an aneurysm of the ascending aorta (0.6%); and failure of previous vein grafts (0.5%). The left anterior descending artery system was grafted by the left internal mammary artery in 53.2%, and the arterial graft was complimented by vein grafts in 2.6%. In 45.2% of the patients, grafts of the left anterior descending artery by the left internal mammary artery were supplemented by vein grafts to the right coronary artery (23.8%), to the circumflex artery (15.2%), or to both (6.2%). The overall operative mortality was 2.2%. It rose to 16.7% with associated cardiac procedures and to 18.5% in patients who were in New York Heart Association Class IV. If these two high-risk categories of patients are excluded, the perioperative death rate in the remaining 750 was only 0.4%. Of the 815 patients who survived the perioperative period (mean 53.1 months follow-up), 63.1% were relieved of angina and 83.4% were in Class I or II of the New York Heart Association, as compared to 27.4% before the operation. At cardiac recatheterization (mean 18.9 months), 87.9% of the internal mammary artery grafts and 63.3% of the vein grafts were patent (p less than 0.05). The cumulative actuarial 10 year survival rate was 88.6% +/- 1.3%.
Which is the apt title for the abstract? option1: Internal mammary artery grafting. Clinical results, patency rates, and long-term survival in 833 patients. option2: An inexpensive wire passer.

SOLUTION: Internal mammary artery grafting. Clinical results, patency rates, and long-term survival in 833 patients.

PROBLEM: Abstract: Children who have been sexually abused develop a variety of emotional and physical complaints, often unrelated to the genital area. Emergency department records of children diagnosed as being sexually abused were reviewed for the period covering January 1984 through June 1985. Of 26,000 patients seen, 300 cases of sexual abuse were identified. Of these, 57 were patients who presented with initial complaints other than sexual abuse. The data were analyzed for age, sex, chief complaint, time of presentation, physical findings, and person accompanying the child. The most common presenting complaints of these 57 patients were abdominal pain (26%) and vaginal symptoms (26%) The latter included pruritus, discharge, and bleeding. Other complaints included rectal bleeding or constipation (9%), chronic urinary tract infection (5%), straddle injury (4%), and suicide attempt (2%). The remaining 26% included fever, respiratory infections, sore throat, asthma, bronchitis, obesity, mastoiditis, and weight loss. Because resident physicians are instructed to conduct complete anal and genital examinations on all patients, sexual misuse was often diagnosed with seemingly unrelated complaints. A protocol developed for use in the emergency department is described.
Which is the apt title for the abstract? option1: Presentation and evaluation of sexual misuse in the emergency department. option2: Fluosol and brain ischemia in gerbils [letter]

SOLUTION: Presentation and evaluation of sexual misuse in the emergency department.

PROBLEM: Abstract: PRL and GH are stored in bovine pituitary secretory granules in part as intermolecular disulfide-linked multimers (as many as 50 monomers/oligomer). In vitro incubation of granules with reduced glutathione (GSH) results in the production of monomeric hormones and increased hormone release. We tested the hypothesis that increases in intragranular osmolality due to conversion of oligomers to lower mol wt forms are key to granule rupture. Hormone release was measured after granule incubations in medium made hyperosmotic by the addition of raffinose or sucrose. PRL release at pH 7.8 with 0.7 M raffinose was reduced to 43.5% of the control value, whereas GH release ranged from 70-100% of the control value. Augmented release stimulated by 2 mM GSH was also diminished by raffinose, to 17.9% (PRL) and 75.6% (GH) of control values. The IC50 for raffinose inhibition of PRL release was 0.62 M; this shifted to 0.38 M in the presence of 2 mM GSH. Raffinose also blunted the granule response to GSH at all other GSH concentrations tested and decreased stimulated release at pH 9 as well as at 7.8. Interference with the ability to maintain an osmotic gradient, a maneuver accomplished by partial disruption of granule membranes with 0.5% deoxycholate treatment, reduced or abolished the raffinose inhibition. Molecular sizing of granule fractions on Superose-6 (Pharmacia) indicated that PRL monomers remaining in the pelletable granule fraction increased with raffinose about 2-fold under both basal and GSH-stimulated conditions. These data support the concept that thiol:disulfide equilibria may be important in PRL and GH storage and secretion by their influence on intragranular osmolality. In exocytosis in vivo, osmotically mediated granule rupture may be triggered by thiols during granule:plasma membrane fusion.
Which is the apt title for the abstract? option1: Osmotic pressure regulation of prolactin and growth hormone release from bovine secretory granules. option2: Severe hemorrhage in a patient with gray platelet syndrome.

SOLUTION:
Osmotic pressure regulation of prolactin and growth hormone release from bovine secretory granules.