Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Input: Consider Input: Pleiotropic effects causes symptoms associated with sickle-cell disease.

Output: What causes symptoms associated with sickle-cell disease?

Input: Consider Input: Ionic compounds contain cations and anions rather than discrete neutral molecules.

Output: Ionic compounds contain cations and anions rather than what?

Input: Consider Input: Air pollution causes acid rain, ozone depletion, and global warming.
Output: What causes acid rain, ozone depletion, and global warming?