In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Ex Input:
The presence of immunoglobulin oligoclonal bands in the cerebrospinal fluid of Multiple Sclerosis (MS) patients supports the hypothesis of an infectious etiology, although the antigenic targets remain elusive. Neurotropic mouse hepatitis virus (MHV) infection in mice provides a useful tool for studying mechanisms of demyelination in a virus-induced experimental model of MS. This study uses Affymetrix microarray analysis to compare differential spinal cord mRNA levels between mice infected with demyelinating and non-demyelinating strains of MHV to identify host immune genes expressed in this demyelinating disease model. The study reveals that during the acute stage of infection, both strains induce inflammatory innate immune response genes, whereas upregulation of several immunoglobulin genes during chronic stage infection is unique to infection with the demyelinating strain. Results suggest that the demyelinating strain induced an innate-immune response during acute infection that may promote switching of Ig isotype genes during chronic infection, potentially playing a role in antibody-mediated progressive demyelination even after viral clearance.

Ex Output:
Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination

Ex Input:
The indirect immunoperoxidase (IIP) assay was compared with the reverse transcription-polymerase chain reaction (RT-PCR) for detection of 793/B serotype of infectious bronchitis virus in tissues samples collected from experimentally infected chickens. This technique was optimized in specific pathogen-free (SPF)-embryonated chicken eggs and broiler chickens inoculated with the Iranian IR/773/2001 strain of 793/B serotype The trachea, lung, kidney, and cecal tonsil tissue samples from experimentally infected chicken embryos and chickens were collected in order to prepare tissue sections in IIP assay and to detect in RT-PCR. The sensitivity and specificity values of IIP assay were, respectively, 83 and 84 %, and the positive and negative prediction values were 71 and 91 % when compared with RT-PCR.

Ex Output:
Detection of 793/B serotype of infectious bronchitis virus in tissue sample by indirect immunoperoxidase assay

Ex Input:
Conventional applications of metapopulation theory have suggested that increasing migration between patches is usually good for conservation. A recent analysis by Hess has pointed out a possible exception to this: when infectious disease is present, migration may promote disease spread and therefore increase local extinction. We extend Hess's model to discuss this problem: when infections have spilled over from more abundant alternative hosts. This is often the case for species of conservation concern, and we find that Hess's conclusions must be substantially modified. We use deterministic analytic and stochastic numerical approaches to show that movement between patches will rarely have a negative impact, even when the probability of external infection is low.

Ex Output:
Disease in endangered metapopulations: the importance of alternative hosts