Instructions: In this task, you are given a abstract of article and corresponding title of an article. Your task is to generate label "yes" if title is right for article, otherwise generate "no".
Input: Abstract: Menstrual and reproductive factors may increase breast cancer risk through a pathway that includes increased mammographic density. We assessed whether known or suspected menstrual and reproductive breast cancer risk factors were cross-sectionally associated with mammographic density, by measuring area of radiographic density and total breast area on mammograms from 801 participants in the Study of Women's Health Across the Nation (SWAN), a multi-ethnic cohort of pre- and early perimenopausal women. From multivariable linear regression, the following menstrual or reproductive factors were independently associated with percent mammographic density (area of dense breast/breast area): older age at menarche ( = 10.3, P < 0.01, for >13 vs. <12 years), premenstrual cravings and bloating ( = 3.36, P = 0.02), younger age at first full-term birth ( = 8.12, P < 0.01 for 23 years versus no births), greater number of births ( = 6.80, P < 0.01 for 3 births versus no births), and premenopausal status ( = 3.78, P < 0.01 versus early perimenopausal). Only number of births remained associated with percent density after adjustment for age, race/ethnicity, study site, body mass index (BMI), and smoking. In addition, stratified analyses revealed that the association with number of births was confined to women within the lowest BMI tertile ( = 12.2, P < 0.01 for 3 births versus no births). Our data support a mechanism for parity and breast cancer that involves mammographic density among pre- and early perimenopausal women that may be modified by body size.. Title: Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
Output:
no