Teacher:In this task, you are given an abstract of article. Your task is to generate title for this article. Preferred titles are under thirty words.
Teacher: Now, understand the problem? Solve this instance: Notch signals are necessary for the functional outcomes of T cell receptor -selection, including differentiation, proliferation and rescue from apoptosis. The mechanism underlying this requirement for T cell development is unknown. Here we show that Notch receptor and Delta-like 1 ligand interactions promoted the survival of CD4CD8 preT cells through the maintenance of cell size, glucose uptake and metabolism. Furthermore, the trophic effects of Notch signaling were mediated by the pathway of phosphatidylinositol-3-OH kinase and the kinase Akt, such that expression of active Atk overcame the requirement for Notch in -selection. Collectively, our results demonstrate involvement of Notch receptorligand interactions in the regulation of cellular metabolism, thus enabling the autonomous signaling capacity of the preT cell receptor complex.*Note: In the version of this article initially published online, in the fourth sentence of the abstract, the term "Atk" was a misspelling; this should be "Akt. " In the fourth sentence of the second paragraph of the introduction, the name of the second kinase mentioned, "PI(3)K-dependent kinase 1," was incorrect; this should read "phosphoinositide-dependent kinase 1. " These errors have been corrected for the HTML and print versions of the article.
Student:
Notch promotes survival of preT cells at the -selection checkpoint by regulating cellular metabolism