Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients.
[A]: Which gene is involved in CADASIL?

[Q]: Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is commonly seen in patients with end-stage renal disease (ESRD), but this condition has not been properly recognized. The prevalence of RLS/WED in ESRD shows the ethnic variation (7%-68%), with the similar tendency of primary RLS/WED. Although RLS/WED in ESRD is defined in secondary RLS/WED, the factors of ESRD that are involved in the genesis of RLS/WED remain unknown. Even after renal transplantation, RLS/WED symptoms do not completely disappear, and genetic predisposition to RLS/WED may play an important role in causing RLS/WED. Long-term intervention for RLS/WED and ESRD will be necessary.
[A]: Willis-Ekbom disease is also known as?

[Q]: Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teens who are playing basketball in the picture above are using force to move their bodies and the basketball, so they are doing work. The teen who is studying isnt moving anything, so she isnt doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. The Figure 1.1 illustrates this point. Q: If the box the man is carrying is very heavy, does he do any work as he walks across the room with it? A: Regardless of the weight of the box, the man does no work on it as he holds it while walking across the room. However, he does more work when he first lifts a heavier box to chest height. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. To see the effects of force and distance on work, compare the weight lifters in the Figure 1.2. The two weight lifters on the left are lifting the same amount of weight, but the one on the bottom is lifting the weight a greater distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight, so she is doing more work.
[A]:
you do more work lifting an object if the object is