In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Rational design of proteins with novel binding specificities and increased affinity is one of the major goals of computational protein design. Epitope-scaffolds are a new class of antigens engineered by transplanting viral epitopes of pre-defined structure to protein scaffolds, or by building protein scaffolds around such epitopes. Epitope-scaffolds are of interest as vaccine components to attempt to elicit neutralizing antibodies targeting the specified epitope. In this study we developed a new computational protocol, MultiGraft Interface, that transplants epitopes but also designs additional scaffold features outside the epitope to enhance antibody-binding specificity and potentially influence the specificity of elicited antibodies. We employed MultiGraft Interface to engineer novel epitope-scaffolds that display the known epitope of HIV-1 neutralizing antibody 2F5 and that also interact with the functionally important CDR H3 antibody loop. MultiGraft Interface generated an epitope-scaffold that bound 2F5 with sub-nanomolar affinity (K D = 400 pM) and that interacted with the antibody CDR H3 loop through computationally designed contacts. Substantial structural modifications were necessary to engineer this antigen, with the 2F5 epitope replacing a helix in the native scaffold and with 15% of the native scaffold sequence being modified in the design stage. This epitope-scaffold represents a successful example of rational protein backbone engineering and protein-protein interface design and could prove useful in the field of HIV vaccine design. MultiGraft Interface can be generally applied to engineer novel binding partners with altered specificity and optimized affinity.
Title: Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5 HHS Public Access

A: False
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Q: Paragraph: In this second part of the chapter on underutilized spices, nine spices are discussed briefl y. They are mango ginger, fragrant pandan, pink pepper, rue, sumac, savory and wasabi. Morphology, chemical composition, medicinal and culinary uses are given briefl y in each of these spices. In addition short notes on 12 lesser known spices are provided; these are blue fenugreek, boldo leaves, chameleon plant, cicely, cresses, epazote, fi nger root, gale, lemon myrtle, Mexican pepper leaf, Tasmanian pepper and water pepper.
Title: Other herbs and spices: mango ginger to wasabi

A: False
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Q: Paragraph: Cornaglia, E.M., Fern~indez, F.M., Gottschalk, M., Barrandeguy, M.E., Luchelli, A., Pasini, M.I., Saif, L.J., Parraud, J.R., Romat, A. and Schudel, A.A., 1992. Reduction in morbidity due to diatthea in nursing beef calves by use of an inactivated oil-adjuvanted rotavirus -Escherichia coli vaccine in the dam. Vet. Microbiol.,. An outbreak of neonatal diarrhea occurred among beef calves (2000 animals) from one large Argentinian farm in 1985. Rotavirus was detected in 78% ( 106/136 ) and enterotoxigenic Escherichia coli in 1.5% of the samples ( 2/136 ) obtained from sick calves. In comparison rotavirus was identified in only 1.6% (1/63) of the samples from clinically healthy calves. The rotavirus strain responsible for the outbreak was characterized as serotype 6 belonging to group A. In the following three years the protective capacity of a combined rotavirus-E, coli inactivated vaccine administered to the dams during the last third of the gestation period was evaluated on this farm by comparison of morbidity due to diarrhea in calves from vaccinated vs. placebo cows within the same year. The morbidity due to diarrhea among calves from dams in the vaccinated and placebo groups was 34% and 77%, respectively in 1986; 23% and 47% in 1987, and 15% and 34%, in 1988. In 1987 morbidity of diarrhea in calves born from vaccinated heifers was 54% and 74% in calves from placebo heifers. In 1988 morbidity from diarrhea was 41% and 54%, respectively among calves in these two groups. In all experiments, calves from heifers showed significantly greater morbidity than calves from cows. Differences in diarrhea morbidity between the vaccinated and placebo groups were statistically significant (P< 0.05 ). Additional studies showed that the diarrhea had a significant influence (P< 0.05 ) on the average live weight of the calves at weaning ( 5 to 7 months ) with an average weight loss of 7.8 kg per calf among the calves affected with diarrhea.
Title: Reduction in morbidity due to diarrhea in nursing beef calves by use of an inactivated oil- adjuvanted rotavirus-Escherichia coli vaccine in the dam

A:
True
****