Most bacteria have a single circular chromosome that can range in size from only 160,000 base pairs in the endosymbiotic bacteria Candidatus Carsonella ruddii, to 12,200,000 base pairs in the soil-dwelling bacteria Sorangium cellulosum. Spirochaetes of the genus Borrelia are a notable exception to this arrangement, with bacteria such as Borrelia burgdorferi, the cause of Lyme disease, containing a single linear chromosome. The genes in bacterial genomes are usually a single continuous stretch of DNA and although several different types of introns do exist in bacteria, these are much rarer than in eukaryotes.
How does chromosome of Borrelia burgdoferi look like?
single linear chromosome

The United States is the chief remaining nation to assign official responsibilities to a region called the Near East. Within the government the State Department has been most influential in promulgating the Near Eastern regional system. The countries of the former empires of the 19th century have in general abandoned the term and the subdivision in favor of Middle East, North Africa and various forms of Asia. In many cases, such as France, no distinct regional substructures have been employed. Each country has its own French diplomatic apparatus, although regional terms, including Proche-Orient and Moyen-Orient, may be used in a descriptive sense. The most influential agencies in the United States still using Near East as a working concept are as follows.
Who has abandoned the term Near East?
The countries of the former empires of the 19th century

The clearance of the pathogens, either treatment-induced or spontaneous, it can be influenced by the genetic variants carried by the individual patients. For instance, for genotype 1 hepatitis C treated with Pegylated interferon-alpha-2a or Pegylated interferon-alpha-2b (brand names Pegasys or PEG-Intron) combined with ribavirin, it has been shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in the treatment-induced clearance of the virus. This finding, originally reported in Nature, showed that genotype 1 hepatitis C patients carrying certain genetic variant alleles near the IL28B gene are more possibly to achieve sustained virological response after the treatment than others. Later report from Nature demonstrated that the same genetic variants are also associated with the natural clearance of the genotype 1 hepatitis C virus.
What is the brand name Pegasys for?
Pegylated interferon-alpha-2b