You will be given a definition of a task first, then some input of the task.
Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

Mitochondrial DNA (mtDNA) copy number correlates with tumor pathology in some cancers.', 'To investigate mtDNA copy number in head and neck cancer (HNC).', 'mtDNA copy number was determined and compared between HNC patients and malignancy-free controls.', 'The mtDNA copy number was significantly higher in HNC patients, increased with cancer progression and correlated negatively with patient survival.
Output:
Is mitochondrial DNA copy number associated with diagnosis and prognosis of head and neck cancer?