input question: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. Uncle Tom and uncle Sam both have high cholesterol. Uncle Tom is on statin drugs and uncle Sam is not. Which uncle doesn't take an inhibitor of the rate limiting enzyme that decreases blood levels of cholesterol????
output answer: Sam

When the temperature of reactants is higher, the rate of the reaction is faster. At higher temperatures, particles of reactants have more energy, so they move faster. As a result, they are more likely to bump into one another and to collide with greater force. For example, food spoils because of chemical reactions, and these reactions occur faster at higher temperatures (see the bread on the left in the Figure below ). This is why we store foods in the refrigerator or freezer (like the bread on the right in the Figure below ). The lower temperature slows the rate of spoilage. A scientist is observing two chemicals react. The reaction is very slow and he wants to find a way to speed up the reaction. One day the labs air conditioner breaks, increasing the heat, in the lab and he notices the reaction is happening significantly faster than usual. Will the chemicals the scientist used react faster or slower if you decrease the temperature?
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Answer: slower

Q: Rural development is the process of improving the quality of life and economic well-being of people living in rural areas, often relatively isolated and sparsely populated areas.[1] Rural development has traditionally centered on the exploitation of land-intensive natural resources such as agriculture and forestry. However, changes in global production networks and increased urbanization have changed the character of rural areas. Increasingly tourism, niche manufacturers, and recreation have replaced resource extraction and agriculture as dominant economic drivers.[2] The need for rural communities to approach development from a wider perspective has created more focus on a broad range of development goals rather than merely creating incentive for agricultural or resource based businesses. Education, entrepreneurship, physical infrastructure, and social infrastructure all play an important role in developing rural regions.[3] Rural development is also characterized by its emphasis on locally produced economic development strategies.[4] In contrast to urban regions, which have many similarities, rural areas are highly distinctive from one another. For this reason there are a large variety of rural development approaches used globally.[5] Rural development is a comprehensive term. It essentially focuses on action for the development of areas outside the mainstream urban economic system. we should think of what type of rural development is needed because modernization of village leads to urbanization and village environment disappears. Two rural communities from Jones county took different approaches on rural development as a means of adapting to increasing urbanization. Kent village remained traditionally centered on the exploitation of land-intensive natural resources such as agriculture and forestry. Long Grove on the other hand took a wider perspective and created more focus on a broad range of development goals rather than merely creating incentive for agricultural or resource based businesses. Education, entrepreneurship, physical infrastructure, and social infrastructure all played an important role in developing Long Grove village. Which village took a more successful approach to rural development?
A: Long Grove

Question: Because of human activities, there is more carbon dioxide in the atmosphere today than in the past hundreds of thousands of years. Burning fossil fuels and has released great quantities of carbon dioxide into the atmosphere. Cutting forests and clearing land has also increased carbon dioxide into the atmosphere because these activities reduce the number of autotrophic organisms that use up carbon dioxide in photosynthesis. In addition, clearing often involves burning, which releases carbon dioxide that was previously stored in autotrophs. When comparing village A from ten thousand years ago to village B from today, we reached the conclusion that today's villagers release much more carbon into the atmosphere by their activities. Which village cleared more land?
Answer: village B

[Q]: A red giant star is a star with a mass like the Sun that is in the last phase of its life, when Hydrogen fusion reactions in the core decrease due to the lack of fuel. With the gravitational collapse of the core, the fusion reactions now occur in a shell surrounding the core. The outer layer of the star expands enormously up to 1000 times the size of the Sun. When the Sun becomes a red giant, its volume will include the orbit of Mercury and Venus and maybe even Earth. The increased size increases the luminosity even though the outer layer cools to only 3000 K or so. The cooler outer layer causes it to be a red star. After a few more million years, the star evolves into a white dwarf-planetary nebula system. Two stars have just been discovered that are identical in terms of chemical composition. The scientist who discovered them was given the right to name them, and he chose the names Enterprise and Vader. As said before, these stars are very similar, but the main difference is that Vader is a red giant, and Enterprise is not. Scientists are very eager to study these two newly discovered stars and see if they can learn anything new from them. Which star is farther from the end of its life?
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[A]: Enterprise

Problem: Given the question: In slippery conditions some riders prefer to ride fixed because they believe the transmission provides increased feedback on back tire grip. However, there is also an increased risk of loss of control in such conditions. This is especially so when taking into account the large number of riders who ride brakeless. These riders must brake entirely through the drivetrain. Ideally this is done by resisting the forward motion of the pedals, shedding speed while the bike is still moving. Alternatively, though far less efficiently, one can brake by stopping the motion of the pedals in mid-rotation, causing the rear wheel to lock in place, allowing the bicycle to skid and slow down from kinetic friction (see below).[22] Descending any significant gradient is more difficult as the rider must spin the cranks at high speed (sometimes at 170 rpm or more), or use the brakes to slow down. Some consider that the enforced fast spin when descending increases suppleness or flexibility, which is said to improve pedalling performance on any type of bicycle; however the performance boost is negligible compared to the benefits of riding a free wheel.[23] Many pro cyclists joined 2 races this month: Bay village race on the 17th, and Hill village bike race on the 25th. Bay village race took place on the shores of the nearby bay, while Hill race took place on the hills and valleys 10 miles away. Bay village race competitors experienced bad weather: a thunderstorm took place during the first hour of the competition. Which race had more cyclists descending a difficult gradient?
++++++++++++++++++++++++++++++++
The answer is:
Hill