Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[Q]: Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.)
Question: Which enzyme is inhibited by a drug fostamatinib?
[A]: spleen tyrosine kinase

[Q]: Context: Rudolf Teschner (16 February 1922, Potsdam -- 23 July 2006, Berlin-Steglitz) was a German chess master and writer.
Question: What nationality of Rudolf Teschner?
[A]: german

[Q]: Context: Here are some books published this year. The following introductions of these books may help you choose a book to your own taste. Life Simplified If you are looking for a book that will transform your life for good, Life Simplified is that book. If you are looking for a guide to inspire and lead you back to your inherent self, Life simplified will act as your compass. Life Simplified provides readers with a carefully mapped approach to create life changes. The reader will develop a sense of personal pride in their progress as each chapter is completed, motivating them further. The book is an absolute must read if you would like an uncomplicated method in positively improving your life. Building the Best You How can you become the person you've always dreamed of being? Personal transformation begins when you take stock of where you are and what you are doing right now...and work to change it. All you have to do is to answer some basic questions and take five minutes of "focus time" daily to get there. You are responding to questions like "What am I grateful for today?", "What challenged me?" and "How can I overcome that challenge?" The Gifts of Imperfection In this latest book, the writer Brown emphasizes that above all other ingredients of living an emotionally healthy life is the importance of loving ourselves. The point is to embrace life and oneself with all the imperfections, releasing the stress of overdoing and overworking. Brown offers exercises for readers to understand their own emotions and begin to develop the kind of resilience needed to refuse unrealistic expectations of others and ourselves. The Strengths Book You are remarkable. But do you always realize it? Realize your strengths and you will be realizing the best of you. Do you want to be confident, successful, and sustainably happy? Do you want to achieve your goals and enjoy better relationships? The Strengths Book reveals the sixty strengths that make us who we are. If you are a manager, a parent, a career changer, or even just you, remarkable as you are, The Strengths Book is for you. Discover your strengths--what you do best and love to do--and transform your life by realizing the best of you.
Question: Which book doesn't involve the topic of change?
[A]:
the gifts of imperfection.