Problem: Antibiotics are screened for any negative effects on humans or other mammals before approval for clinical use, and are usually considered safe and most are well tolerated. However, some antibiotics have been associated with a range of adverse side effects. Side-effects range from mild to very serious depending on the antibiotics used, the microbial organisms targeted, and the individual patient. Side effects may reflect the pharmacological or toxicological properties of the antibiotic or may involve hypersensitivity reactions or anaphylaxis. Safety profiles of newer drugs are often not as well established as for those that have a long history of use. Adverse effects range from fever and nausea to major allergic reactions, including photodermatitis and anaphylaxis. Common side-effects include diarrhea, resulting from disruption of the species composition in the intestinal flora, resulting, for example, in overgrowth of pathogenic bacteria, such as Clostridium difficile. Antibacterials can also affect the vaginal flora, and may lead to overgrowth of yeast species of the genus Candida in the vulvo-vaginal area. Additional side-effects can result from interaction with other drugs, such as elevated risk of tendon damage from administration of a quinolone antibiotic with a systemic corticosteroid. Some scientists have hypothesized that the indiscriminate use of antibiotics alter the host microbiota and this has been associated with chronic disease.
What is one possible serious side effect of over-using antibiotics?
The answer is the following: alter the host microbiota

Problem: In August 1836, two real estate entrepreneursAugustus Chapman Allen and John Kirby Allenfrom New York, purchased 6,642 acres (26.88 km2) of land along Buffalo Bayou with the intent of founding a city. The Allen brothers decided to name the city after Sam Houston, the popular general at the Battle of San Jacinto, who was elected President of Texas in September 1836. The great majority of slaves in Texas came with their owners from the older slave states. Sizable numbers, however, came through the domestic slave trade. New Orleans was the center of this trade in the Deep South, but there were slave dealers in Houston. Thousands of enslaved African-Americans lived near the city before the Civil War. Many of them near the city worked on sugar and cotton plantations, while most of those in the city limits had domestic and artisan jobs. In 1860 forty-nine percent of the city's population was enslaved. A few slaves, perhaps as many as 2,000 between 1835 and 1865, came through the illegal African trade. Post-war Texas grew rapidly as migrants poured into the cotton lands of the state. They also brought or purchased enslaved African Americans, whose numbers nearly tripled in the state from 1850 to 1860, from 58,000 to 182,566.
Who bought land along Buffalo Bayou to build a city?
The answer is the following: Allen brothers

Problem: He also developed Feynman diagrams, a bookkeeping device that helps in conceptualizing and calculating interactions between particles in spacetime, including the interactions between electrons and their antimatter counterparts, positrons. This device allowed him, and later others, to approach time reversibility and other fundamental processes. Feynman's mental picture for these diagrams started with the hard sphere approximation, and the interactions could be thought of as collisions at first. It was not until decades later that physicists thought of analyzing the nodes of the Feynman diagrams more closely. Feynman painted Feynman diagrams on the exterior of his van.
What did Feynman produce that help in understanding calculations between particles in space and time?
The answer is the following: Feynman diagrams

Problem: Some of the earliest recorded observations ever made through a telescope, Galileo's drawings on 28 December 1612 and 27 January 1613, contain plotted points that match up with what is now known to be the position of Neptune. On both occasions, Galileo seems to have mistaken Neptune for a fixed star when it appeared closein conjunctionto Jupiter in the night sky; hence, he is not credited with Neptune's discovery. At his first observation in December 1612, Neptune was almost stationary in the sky because it had just turned retrograde that day. This apparent backward motion is created when Earth's orbit takes it past an outer planet. Because Neptune was only beginning its yearly retrograde cycle, the motion of the planet was far too slight to be detected with Galileo's small telescope. In July 2009, University of Melbourne physicist David Jamieson announced new evidence suggesting that Galileo was at least aware that the 'star' he had observed had moved relative to the fixed stars.
What happens when Neptune goes retrograde?
The answer is the following:
Earth's orbit takes it past an outer planet