You will be given a definition of a task first, then some input of the task.
In this task, you are given a abstract of article and corresponding title of an article. Your task is to generate label "yes" if title is right for article, otherwise generate "no".

Abstract: Transforming growth factor (TGF) is a potent and context-dependent regulator of tumor progression. TGF promotes the lung metastasis of basal-like (but not the luminal-like) breast cancer. Here, we demonstrated that fascin, a pro-metastasis actin bundling protein, was a direct target of the canonical TGF-Smad4 signaling pathway in basal-like breast cancer cells. TGF and Smad4 induced fascin overexpression by directly binding to a Smad binding element on the fascin promoter. We identified GATA3, a transcription factor crucial for mammary gland morphogenesis and luminal differentiation, as a negative regulator of TGF- and Smad4-induced fascin overexpression. When ectopically expressed in basal-like breast cancer cells, GATA-3 abrogated TGF- and Smad4-mediated overexpression of fascin and other TGF response genes, invadopodium formation, cell migration, and invasion, suggesting suppression of the canonical TGF-Smad signaling axis. Mechanistically, GATA3 abrogated the canonical TGF-Smad signaling by abolishing interactions between Smad4 and its DNA binding elements, potentially through physical interactions between the N-terminal of GATA3 and Smad3/4 proteins. Our findings provide mechanistic insight into how TGF-mediated cell motility and invasiveness are differentially regulated in breast cancer.. Title: The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases
Output:
no