TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P.05), and naproxen resulted in significant improvement of LBPI vs placebo (P.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.

SOLUTION: What is the target of tanezumab?

PROBLEM: Once acquired, Epstein-Barr virus (EBV), a latent virus, remains in the body for what appears to be the lifetime of the human host. Circumstantial data suggest EBV is involved in clinical disease including malignancies far more often than previously recognized. A serologic test for early antigen (EA) is more specific for diagnosing active EBV disease than the monospot or heterophile test. A case study of active Epstein-Barr infection is reported showing persistently elevated early antigen titers prior to and following malignant transformation.

SOLUTION: Which virus can be diagnosed with the monospot test?

PROBLEM: Nuclear-powered aircraft carriers are considered one of the most important marine weapons in the 20th century. So far, only two countries in the world--the prefix = st1 /USAandFrance--have ever produced them. But these frightful fighting machines are about to enter Asia. The US Navy said last month that one of its nine nuclear-powered aircraft carriers will be sent to Japanto replace the diesel-powered carrier Kitty Hawk in 2009 in an agreement on October 30th. The two countries also planned to level up their military cooperation and theUSAcalled forJapanto take a large role in alliance military moves. It will be the first time that a nuclear-powered carrier is based in Japan. Bombed byUSforces in World War II at Hiroshima and Nagasaki,Japanis the only world country to have been attacked by a nuclear weapon. Therefore, the citizens are highly sensitive to where nuclear-powered weapons are based. "A radiation leak at Yokosuka would kill 100,000 people as far away as Tokyo, and could cause billions of dollars in damage," said Masahiko Go to, leader of a protest group inYokosuka. His group has collected more than 300,000 signatures of people acrossJapanopposed to the nuclear carrier. The 44-year-old Kitty Hawk, the USnavy's oldest active ship, has been based in Yokosuda since 1998. The new carrier, yet to be _ , will travel faster, be capable of supporting longer operations and carry with it the Navy's most modern technology. Experts pointed that this change is not only to strengthen the US-Japan military alliance but also to keep the military power of ChinaandNorth Koreawithin limits. However, Japanese experts don't believe that the countries are threats to the region. "There is no need for Japanto have a nuclear carrier as defense," said Tetsuo Maeda, an international relations professor atTokyoInternationalUniversity. He said that the change of ship indicates an increased military capacity, in the region, much more than what is needed.

SOLUTION:
The replacement of the aircraft carrier is intended to