In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: The access of drugs to the central Nervous System is conditioned by the existence of the blood-brain barrier (BHE) barrier:
Options: <1> Increases its permeability in case of inflammation. <2> It is homogeneous throughout the encephalon. <3> It is traversed freely by fat-soluble drugs. <4> It is maximum in the chemoreceptor area of the trigger. <5> Decreases its permeability in case of inflammation.
1

Question: The structure of the personality can be organized according to:
Options: <1> The three-dimensional model of R.B. Cattell. <2> The five-factor proposal of Zuckerman. <3> The five basic factors of Cantor and Kihstrom. <4> The sixteen factors of H.J. Eysenck. <5> The Monorrasgo theory of Costa and McCrae.
2

Question: Which of the following heterocycles is considered a bioisosterer of the catecholic system ?:
Options: <1> Pyridine <2> Indole. <3> Tetrazol <4> Thiophene <5> Benzimidazole
5