instruction:
Given an abstract of a paper, generate a title for this paper such that conveys the key focus of the paper.
question:
Abstract: When bovine parathyroid cells in culture are exposed to the active vitamin D metabolite 1,25(OH)2D3, a significant decrease in the steady-state levels of pre-proparathyroid hormone (pre-proPTH) mRNA occurs. The possibility that the fall in specific mRNA is due to a decrease in rate of transcription of the PTH gene was examined in this study. In the presence of 1,25(OH)2D3, there was a rapid and steady decline in PTH gene transcription rate which fell to a minimum of 10-15% of control at 24 h. The effect was observed at physiological levels (10(-11)M) and was also fully reversible.
answer:
Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene.

question:
Abstract: To achieve adequate arterial BP, adequate capillary filling time, and adequate peripheral pulses, hypotensive newborn infants often require higher doses of dopamine that reportedly reduce urine output in adults. Whether these larger doses of dopamine also reduce urine output in newborns is not known. Therefore, we determined the effects of administering high-dose dopamine (more than 20 micrograms/kg X min) on the urine output of 15 newborn infants. Five infants were studied prospectively and ten retrospectively. In the prospective study, urine output was determined as the dose of dopamine was increased; in the retrospective study, urine output was determined as the infants were being weaned from high doses of dopamine. Both data sets demonstrate that administering high-dosage dopamine does not reduce the urine output of sick newborn infants. Therefore, we conclude that doses of dopamine previously reported to decrease urine output in adults do not do so in sick newborn infants. Consequently, when necessary, high doses of dopamine may be used in sick newborn infants to achieve cardiovascular stability without reducing urine output.
answer:
Effect of high-dose dopamine on urine output in newborn infants.

question:
Abstract: The epidemiology of severe burns is analysed. From 1 September 1982 to 31 August 1983 75 patients, 27 females and 48 males were admitted to the Burns Unit in Copenhagen. The majority of burns were domestic and fire was the predominant cause. The most vulnerable areas were the arms and the legs, and small children still have the highest incidence of thermal injury. As predisposing factors were of significance in several accidents, the importance of further prevention is stressed.
answer:
Epidemiology of severe burn injuries.