Teacher:In this task, you are given a abstract of article and corresponding title of an article. Your task is to generate label "yes" if title is right for article, otherwise generate "no".
Teacher: Now, understand the problem? Solve this instance: Abstract: INTERACTIONS between major histocompatibility complex (MHC) molecules and the CD4 or CDS coreceptors have a major role in intrathymic T-cell selection1. On mature T cells, each of these two glycoproteins is associated with a class-specific bias in MHC molecule recognition by the T-cell receptor. CD4+ T cells respond to antigen in association with MHC class II molecules and CD8+ T cells respond to antigen in association with MHC class I molecules. Physical interaction between the CD4/MHC class II molecules and CD8/MHC class I molecules has been demonstrated by cell adhesion assay25, and a binding site for CDS on class I has been identified6,7. Here we demonstrate that a region of the MHC class II-chain 2 domain, structurally analogous to the CDS-binding loop in the MHC class I 3 domain, is critical for function with both mouse and human CD4.. Title: MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8
Student:
yes