instruction:
Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).
question:
Abstract: Non-excretor cirrhotic patients, defined by their inability to normally excrete a standard water load, display variable responses to head-out water immersion. The hemodynamic, hormonal, and renal functional status of fifteen such patients were analyzed relative to water excretion during head-out water immersion. Group 1 patients (N = 7) all excreted less than 40% of the water load during immersion, whereas excretion was greater than 40% in all eight patients in Group 2. Group 1 patients, when compared with Group 2, had more ascites, more diuretic resistance, lower serum sodium concentration (125 +/- 2 vs. 130 +/- 1 mEq/liter, P less than 0.05), and more impaired baseline water excretion (12.9 +/- 1.2 vs. 35.9 +/- 5.9% of water load in 5 hr, P less than 0.005). Systemic hemodynamic responses to water immersion were similar in both groups. Glomerular filtration rate and renal plasma flow were significantly more impaired in Group 1 patients (inulin clearance 28 +/- 6 vs. 62 +/- 9 ml/min/1.73 m2, P less than 0.05; para-aminohippurate clearance 212 +/- 35 vs. 357 +/- 37 ml/min, P less than 0.05). Concentrations of plasma vasopressin (1.7 +/- 0.5 vs. 0.8 +/- 0.1 pg/ml, P less than 0.05), renin (8.6 +/- 1.7 vs. 3.8 +/- 0.9 ng/ml/hr, P less than 0.05), aldosterone (82 +/- 14 vs. 39 +/- 10 ng/dl, P less than 0.05) and norepinephrine (1155 +/- 183 vs. 603 +/- 126 pg/ml, P less than 0.05) were all significantly higher in Group 1 than Group 2 patients during water immersion.(ABSTRACT TRUNCATED AT 250 WORDS)
Which is the apt title for the abstract? option1: Factors determining renal response to water immersion in non-excretor cirrhotic patients. option2: Primary amebic meningoencephalitis.
answer:
Factors determining renal response to water immersion in non-excretor cirrhotic patients.

question:
Abstract: Early cellular events in the malignant transformation of melanocytes to melanoma are virtually unknown. In vitro investigation of this phenomenon has been hampered by the fastidious nature of the human epidermal melanocyte, which has proven difficult to cultivate. The present study compares responsiveness of cultured human epidermal melanocytes and established melanoma cell lines to serum, cholera toxin, and melanocyte growth factor (MGF), three established melanocyte mitogens. Four of four established human melanoma lines were substantially stimulated by fetal bovine serum, as were newborn foreskin-derived epidermal melanocytes. In contrast, none of the four melanoma lines responded to hypothalamic preparations containing MGF that consistently produced an approximately 30-fold increase in newborn melanocyte cell yield over a 2-week period. Cholera toxin, required for successful establishment of primary melanocyte cultures, had small and variable effects on the melanoma lines, with slight stimulation in one case, moderate inhibition in another, and essentially no effect in two others. These data suggest that transformation of epidermal melanocytes to melanoma often involves at least one phenotypic change resulting in escape from MGF regulation and another associated with insensitivity to cyclic AMP modulation; while at least some of the pathways conferring serum dependence are unaltered. Improved culture systems for the human epidermal melanocyte should facilitate further studies into the mechanism of its malignant conversion and may provide useful insights for the prevention and treatment of human melanoma.
Which is the apt title for the abstract? option1: Relative responsiveness of cultured human epidermal melanocytes and melanoma cells to selected mitogens. option2: A new subunit of the human T-cell antigen receptor complex.
answer:
Relative responsiveness of cultured human epidermal melanocytes and melanoma cells to selected mitogens.

question:
Abstract: Our results suggest that ethylene oxide retention after sterilization is increased in cuprammonium cellulose plate dialyzers containing potting compound. In contrast, cuprammonium cellulose plate dialyzers without potting compound were characterized by a rapid disappearance of retained ethylene oxide after sterilization. Whether these findings explain the low incidence of SARD with cuprammonium cellulose plate dialyzers that do not contain potting material is a matter for continued study and experimentation.
Which is the apt title for the abstract? option1: Extractable ethylene oxide from cuprammonium cellulose plate dialyzers: importance of potting compound. option2: Facial involvement in pruritic urticarial papules and plaques of pregnancy [letter]
answer:
Extractable ethylene oxide from cuprammonium cellulose plate dialyzers: importance of potting compound.