QUES: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.

Who reported the stable average rate in 2012?
What is the answer?
ANS: Professors Light and Lexchin
QUES: The PLP, the party in government when the decision to join CARICOM was made, has been dominated for decades by West Indians and their descendants. (The prominent roles of West Indians among Bermuda's black politicians and labour activists predated party politics in Bermuda, as exemplified by Dr. E. F. Gordon). The late PLP leader, Dame Lois Browne-Evans, and her Trinidadian-born husband, John Evans (who co-founded the West Indian Association of Bermuda in 1976), were prominent members of this group. They have emphasised Bermuda's cultural connections with the West Indies. Many Bermudians, both black and white, who lack family connections to the West Indies have objected to this emphasis.

Who had dominated CARICOM?
What is the answer?
ANS: unanswerable
QUES: East Tucson is relatively new compared to other parts of the city, developed between the 1950s and the 1970s,[citation needed] with developments such as Desert Palms Park. It is generally classified as the area of the city east of Swan Road, with above-average real estate values relative to the rest of the city. The area includes urban and suburban development near the Rincon Mountains. East Tucson includes Saguaro National Park East. Tucson's "Restaurant Row" is also located on the east side, along with a significant corporate and financial presence. Restaurant Row is sandwiched by three of Tucson's storied Neighborhoods: Harold Bell Wright Estates, named after the famous author's ranch which occupied some of that area prior to the depression; the Tucson Country Club (the third to bear the name Tucson Country Club), and the Dorado Country Club. Tucson's largest office building is 5151 East Broadway in east Tucson, completed in 1975. The first phases of Williams Centre, a mixed-use, master-planned development on Broadway near Craycroft Road, were opened in 1987. Park Place, a recently renovated shopping center, is also located along Broadway (west of Wilmot Road).

When was East Tucson developed?
What is the answer?
ANS:
between the 1950s and the 1970s