Mike survived the accident but spent 6 months in the Fairview hospital. When he woke up, he was diagnosed with retrograde amnesia, causing him to forget the last 2 years. Edie Britt took advantage, telling him that Susan had treated him like dirt to make Mike fall in love with her. They had a brief relationship which she ended when he was arrested for Monique Polier's murder. Susan pursued her new boyfriend, Ian, to hire the best lawyer to get Mike out of jail. In prison, Paul tried befriending Mike so Zach would help him find Felicia Tilman( Mrs. Hughes' sister), who had accused Paul murdering her sister. Later, he visited a hypnotherapist to try to make sense of some memories. He realized Orson Hodge(who married Bree Van De Kamp) was responsible. He and Mike had a fight on the hospital roof and Orson fell off. Mike was cleared when the police found Alma and Monique's teeth and suicide note Alma wrote when she pretended to die.

Is it true that does mike come out of a coma in desperate housewives?
yes