Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis.
Question: Which molecule is targeted by a monoclonal antibody Secukinumab?
[EX A]: interleukin-17a

[EX Q]: Context: September 1939. Mrs. Kay Miniver (Greer Garson) and her family live a comfortable life at a house called 'Starlings' in Belham, a fictional village outside London, England. The house has a large garden, with a private landing stage on the River Thames at which is moored a motorboat belonging to her devoted husband Clem (Walter Pidgeon), a successful architect. They have three children: the youngsters Toby and Judy (Christopher Severn and Clare Sandars) and an older son Vin (Richard Ney) at university. They have live-in staff: Gladys the housemaid (Brenda Forbes) and Ada the cook (Marie De Becker).As World War II looms, Vin comes down from university and meets Carol Beldon (Teresa Wright), granddaughter of Lady Beldon (Dame May Whitty) from nearby Beldon Hall. Despite initial disagreements (mainly contrasting Vin's idealistic attitude to class differences with Carol's practical altruism) they fall in love. Vin proposes to Carol in front of his family at home after his younger brother prods him to give a less romantic but more honest proposal.Several months later, as the war comes closer to home with the bombing of Great Brittan, Vin feels he must "do his bit" and enlists in the Royal Air Force, qualifying as a fighter pilot. He is posted to a base near to his parents' home and is able to signal his safe return from operations to his parents by cutting his engines briefly as he flies over the house. Together with other boat owners, Clem volunteers to take his motorboat to assist in the May-June 1940 Dunkirk evacuation.Early one morning, Kay unable to sleep as Clem is still away, wanders down to the landing stage. She is startled to discover a wounded German pilot (Helmut Dantine) hiding in her garden and he holds her at gunpoint. Demanding food and a coat, the pilot maniacally asserts that the Third Reich will mercilessly overcome its enemies. She feeds him, calmly disarms him and then calls the police. Soon after, Clem returns home, exhausted, from Dunkirk.Lady Beldon visits Kay to try and convince her to talk Vin out of marrying Carol on account of her granddaughter's comparative youth. Lady Beldon is unsuccessful and admits defeat when Kay reminds her that she, too, was young when she married her late husband. Lady Beldon concedes defeat and realises that she would be foolish to try and stop the marriage. Vin and Carol are married; Carol has now also become Mrs Miniver, and they return from their honeymoon in Scotland. A key theme is that she knows he is likely to be killed in action, but the short love will fill her life. Later, Kay and her family take refuge in their Anderson shelter in the garden during an air raid, and attempt to keep their minds off the frightening bombing by reading Alice's Adventures in Wonderland, which Clem refers to as a "lovely story" as they barely survive a bomb destroys parts of the house. They take the damage with nonchalance.At the annual village flower show, Lady Beldon silently disregards the judges' decision that her rose is the winner, instead announcing the entry of the local stationmaster, Mr. Ballard (Henry Travers), named the "Mrs. Miniver" rose, as the winner, with her own rose taking second prize. As air raid sirens sound and the villagers take refuge in the cellars of Beldon Hall, Kay and Carol drive Vin to join his squadron. On their journey home they witness fighter planes in a 'dogfight'. For safety, Kay stops the car and they see the German plane crash. Kay realises Carol has been wounded by shots from the plane and takes her back to 'Starlings'. She dies a few minutes after they reach home. Kay is devastated. When Vin returns from battle, he already knows the terrible news. Unexpectedly he is the survivor, and she the one who gives her life for England.The villagers assemble at the badly damaged church where their vicar (Henry Wilcoxon) affirms their determination in a powerful sermon:"We in this quiet corner of England have suffered the loss of friends very dear to us, some
Question: Who enlists in the Royal Air Force?
[EX A]: vin

[EX Q]: Context: All rocks on Earth change, but these changes usually happen very slowly. Some changes happen below Earths surface. Some changes happen above ground. These changes are all part of the rock cycle. The rock cycle describes each of the main types of rocks, how they form and how they change. Figure 4.1 shows how the three main rock types are related to each other. The arrows within the circle show how one type of rock may change to rock of another type. For example, igneous rock may break down into small pieces of sediment and become sedimentary rock. Igneous rock may be buried within the Earth and become metamorphic rock. Igneous rock may also change back to molten material and re-cool into a new igneous rock. Rocks are made of minerals. The minerals may be so tiny that you can only see them with a microscope. The minerals may be really large. A rock may be made of only one type of mineral. More often rocks are made of a mixture of different minerals. Rocks are named for the combinations of minerals they are made of and the ways those minerals came together. Remember that different minerals form under different environmental conditions. So the minerals in a rock contain clues about the conditions in which the rock formed (Figure 4.2). Geologists group rocks based on how they were formed. The three main kinds of rocks are: 1. Igneous rocks form when magma cools below Earths surface or lava cools at the surface (Figure 4.3). 2. Sedimentary rocks form when sediments are compacted and cemented together (Figure 4.4). These sediments may be gravel, sand, silt or clay. Sedimentary rocks often have pieces of other rocks in them. Some sedimentary rocks form the solid minerals left behind after a liquid evaporates. 3. Metamorphic rocks form when an existing rock is changed by heat or pressure. The minerals in the rock change but do not melt (Figure 4.5). The rock experiences these changes within the Earth. Rocks can be changed from one type to another, and the rock cycle describes how this happens. Any type of rock can change and become a new type of rock. Magma can cool and crystallize. Existing rocks can be weathered and eroded to form sediments. Rock can change by heat or pressure deep in Earths crust. There are three main processes that can change rock: Cooling and forming crystals. Deep within the Earth, temperatures can get hot enough to melt rock. This molten material is called magma. As it cools, crystals grow, forming an igneous rock. The crystals will grow larger if the magma cools slowly, as it does if it remains deep within the Earth. If the magma cools quickly, the crystals will be very small. Weathering and erosion. Water, wind, ice, and even plants and animals all act to wear down rocks. Over time they can break larger rocks into smaller pieces called sediments. Moving water, wind, and glaciers then carry these pieces from one place to another. The sediments are eventually dropped, or deposited, somewhere. The sediments may then be compacted and cemented together. This forms a sedimentary rock. This whole process can take hundreds or thousands of years. Metamorphism. This long word means to change form. A rock undergoes metamorphism if it is exposed to extreme heat and pressure within the crust. With metamorphism, the rock does not melt all the way. The rock changes due to heat and pressure. A metamorphic rock may have a new mineral composition and/or texture. An interactive rock cycle diagram can be found here: The rock cycle really has no beginning or end. It just continues. The processes involved in the rock cycle take place over hundreds, thousands, or even millions of years. Even though for us rocks are solid and unchanging, they slowly change all the time.
Question: any mixture of minerals in the solid state
[EX A]:
rock