Teacher:In this task, you are given an abstract of article. Your task is to generate title for this article. Preferred titles are under thirty words.
Teacher: Now, understand the problem? Solve this instance: The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive evidence of association (P < 105) were examined in collections from Belgium, Finland, Italy and Spain totaling 3,978 Alzheimer's disease cases and 3,297 controls. Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.810.90, P = 7.5 109 for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.141.29, P = 3.7 109 for combined data). Previous biological studies support roles of CLU and CR1 in the clearance of amyloid (A) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease.
Student:
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease