Question: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.
Try to answer this question if possible: What was discovered in short term studies?
Answer: unanswerable
Question: In league competitions, games may end in a draw. In knockout competitions where a winner is required various methods may be employed to break such a deadlock, some competitions may invoke replays. A game tied at the end of regulation time may go into extra time, which consists of two further 15-minute periods. If the score is still tied after extra time, some competitions allow the use of penalty shootouts (known officially in the Laws of the Game as "kicks from the penalty mark") to determine which team will progress to the next stage of the tournament. Goals scored during extra time periods count toward the final score of the game, but kicks from the penalty mark are only used to decide the team that progresses to the next part of the tournament (with goals scored in a penalty shootout not making up part of the final score).
Try to answer this question if possible: Which goals count to the final score of the game?
Answer: Goals scored during extra time
Question: Cordwood construction can save significant space and was often used with wire-ended components in applications where space was at a premium (such as missile guidance and telemetry systems) and in high-speed computers, where short traces were important. In cordwood construction, axial-leaded components were mounted between two parallel planes. The components were either soldered together with jumper wire, or they were connected to other components by thin nickel ribbon welded at right angles onto the component leads. To avoid shorting together different interconnection layers, thin insulating cards were placed between them. Perforations or holes in the cards allowed component leads to project through to the next interconnection layer. One disadvantage of this system was that special nickel-leaded components had to be used to allow the interconnecting welds to be made. Differential thermal expansion of the component could put pressure on the leads of the components and the PCB traces and cause physical damage (as was seen in several modules on the Apollo program). Additionally, components located in the interior are difficult to replace. Some versions of cordwood construction used soldered single-sided PCBs as the interconnection method (as pictured), allowing the use of normal-leaded components.
Try to answer this question if possible: What was not soldered together?
Answer: unanswerable
Question: The Time Warner Cable Music Pavilion at Walnut Creek hosts major international touring acts. In 2011, the Downtown Raleigh Amphitheater opened (now sponsored as the Red Hat Amphitheater), which hosts numerous concerts primarily in the summer months. An additional amphitheater sits on the grounds of the North Carolina Museum of Art, which hosts a summer concert series and outdoor movies. Nearby Cary is home to the Koka Booth Amphitheatre which hosts additional summer concerts and outdoor movies, and serves as the venue for regularly scheduled outdoor concerts by the North Carolina Symphony based in Raleigh. During the North Carolina State Fair, Dorton Arena hosts headline acts. The private Lincoln Theatre is one of several clubs in downtown Raleigh that schedules many concerts throughout the year in multiple formats (rock, pop, country).
Try to answer this question if possible: What event plaza is in Cary?
Answer:
Koka Booth Amphitheatre