Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Urgent surgery or life-threatening bleeding requires prompt reversal of the anticoagulant effects of dabigatran. This study assessed the ability of three- and four-factor prothrombin complex concentrate (PCC) and idarucizumab (specific antidote for dabigatran) to reverse the anticoagulant effects of dabigatran in a porcine model of trauma. Twelve animals were given dabigatran etexilate (DE) orally and dabigatran intravenously, before infliction of trauma. Six animals received tranexamic acid plus fibrinogen concentrate 12 minutes post-injury. Six PCCs (each 30 and 60 U/kg) and idarucizumab (30 and 60 mg/kg) were added to blood samples ex vivo. Coagulation was assessed by several coagulation assays. All coagulation parameters were altered after dabigatran infusion (plasma level: 442 138 ng/ml). Both three- and four-factor PCCs mostly or completely reversed the effects of dabigatran on thromboelastometry variables and PT but not on aPTT. Idarucizumab neutralised plasma concentrations of dabigatran, and reversed the effects of the drug on coagulation variables. Thrombin generation showed dose-dependent over-correction following the addition of PCC, implying that elevated levels of thrombin are required to overcome dabigatran-induced coagulopathy. In contrast, treatment with idarucizumab returned thrombin generation to baseline levels. Following trauma, therapy with tranexamic acid plus fibrinogen improved correction of coagulation parameters by PCC, and thromboelastometry parameters by idarucizumab. All investigated PCCs improved dabigatran- and trauma-induced coagulopathy to a similar degree. In conclusion, this study shows that three- and four-factor PCCs are similarly effective for dabigatran reversal. Idarucizumab also reversed the effects of dabigatran and, unlike PCCs, was not associated with over-correction of thrombin generation.
Which drug can be reversed with idarucizumab?

Les Abencerages, ou L'etendard de Grenade (English: The Abencerrages, or The Standard of Granada) is an opera in three acts by Luigi Cherubini with a French libretto by Etienne de Jouy, based on the novel Gonzalve de Cordoue by Jean-Pierre Claris de Florian.
Which place is Les Abencerages in?

When two or more waves meet, they interact with each other. The interaction of waves with other waves is called wave interference. Wave interference may occur when two waves that are traveling in opposite directions meet. The two waves pass through each other, and this affects their amplitude. Amplitude is the maximum distance the particles of the medium move from their resting positions when a wave passes through. How amplitude is affected by wave interference depends on the type of interference. Interference can be constructive or destructive. Constructive interference occurs when the crests, or highest points, of one wave overlap the crests of the other wave. You can see this in the Figure 1.1. As the waves pass through each other, the crests combine to produce a wave with greater amplitude. Destructive interference occurs when the crests of one wave overlap the troughs, or lowest points, of another wave. The Figure 1.2 shows what happens. As the waves pass through each other, the crests and troughs cancel each other out to produce a wave with zero amplitude. Waves may reflect off an obstacle that they are unable to pass through. When waves are reflected straight back from an obstacle, the reflected waves interfere with the original waves and create standing waves. These are waves that appear to be standing still. Standing waves occur because of a combination of constructive and destructive interference. Q: How could you use a rope to produce standing waves? A: You could tie one end of the rope to a fixed object, such as doorknob, and move the other end up and down to generate waves in the rope. When the waves reach the fixed object, they are reflected back. The original waves and the reflected waves interfere to produce a standing wave. Try it yourself and see if the waves appear to stand still.
when two waves pass through each other in opposite directions, the interference affects their