instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: In this study, we report the complete genome sequence of two contemporary human coronavirus OC43 (HCoV-OC43) strains detected in 2003 and 2004, respectively. Comparative genetic analyses of the circulating strains and the prototype HCoV-OC43 strain (ATCC VR759) were performed. Remarkably, a lower than expected similarity is found between the complete genomes and more in particular between the spike genes of the BE03 and BE04 strains. This finding suggests the existence of two genetically distinct HCoV-OC43 strains, circulating in Belgium in 2003 and 2004. Spike gene sequencing of three additional 2003 and two additional 2004 HCoV-OC43 strains, and subsequent phylogenetic analysis confirm this assumption. Compared to the ATCC prototype HCoV-OC43 strain, an important amino acid substitution is present in the potential cleavage site sequence of the spike protein of all contemporary strains, restoring the N-RRXRR-C motif, associated with increased spike protein cleavability in bovine coronaviruses. We here describe specific characteristics associated with circulating HCoV-OC43 strains, and we provide substantial evidence for the genetic variability of HCoV-OC43. D
Title: Circulation of genetically distinct contemporary human coronavirus OC43 strains
answer:
True

question:
Paragraph: Basic and translational research on lung biology has discovered multiple progenitor cell types, specialized or facultative, responsible for turnover, renewal, and repair. Isolation of populations of resident lung progenitor cells (LPCs) has been described by multiple protocols, and some have been successfully applied to healthy human lung tissue. We aimed at understanding how different cell culture conditions may affect, in vitro, the phenotype of LPCs to create an ideal niche-like microenvironment. The influence of different substrates (i.e., fibronectin, gelatin, laminin) and the impact of a three-dimensional/two-dimensional (3D/2D) culture switch on the biology of LPCs isolated as lung spheroids (LSs) from normal adult human lung biopsy specimens were investigated. We applied a spheroid culture system as the selective/inductive step for progenitor cell culture, as described in many biological systems. The data showed a niche-like proepithelial microenvironment inside the LS, highly sensitive to the 3D culture system and significantly affecting the phenotype of adult LPCs more than culture substrate. LSs favor epithelial phenotypes and LPC maintenance and contain cells more responsive to specific commitment stimuli than 2D monolayer cultures, while secreting a distinctive set of paracrine factors. We have shown for the first time, to our knowledge, how culture as 3D LSs can affect LPC epithelial phenotype and produce strong paracrine signals with a distinctive secretomic profile compared with 2D monolayer conditions. These findings suggest novel approaches to maintain ex vivo LPCs for basic and translational studies. STEM CELLS TRANSLATIONAL MEDICINE 2016;5:1-11 SIGNIFICANCE A lung niche-like microenvironment was created ex vivo inside the pneumosphere. Pneumospheres have a distinctive secretomic profile compared with two-dimensional culture. Three-dimensional culture switch significantly affects lung progenitor phenotype. Lung progenitors in pneumospheres were more committed toward epithelial lineages.
Title: Tissue-Specific Progenitor and Stem Cells Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells With Distinctive Paracrine and Plasticity Properties
answer:
True

question:
Paragraph: A 19-day-old female infant was admitted to a neonatal ICU in Ankara, Turkey. A product of an unremarkable gestation and vaginal delivery at 39 weeks, she began to have symptoms of an upper respiratory infection at the age of 15 days. The illness abruptly worsened 3 days later with cough, cyanosis, periods of apnea, and progressive respiratory failure precipitating her admission. The mother, who had received DPT (diphtheria, pertussis, and tetanus) vaccination as a child, reported a mild cough beginning in the 2 weeks prior to delivery. Upon arrival, the infant was having apneic episodes with cyanosis and her O 2 saturation dropped to 36% during a coughing spasm. An initial white blood cell count was 27,200/L with 60% lymphocytes and a chest X-ray did not reveal any infiltrates. Despite ampicillin and gentamicin, she deteriorated further and endotracheal intubation was necessary but was discontinued on day 2 of her admission. Nasopharyngeal washings were tested by PCR and were negative for respiratory syncytial virus, influenza A and B, adenovirus, parainfluenza virus, and coronavirus. Based on the infant's symptom complex and lymphocytosis, she had erythromycin therapy added on day 4. Nasopharyngeal aspirates obtained before erythromycin treatment was begun were positive for pertussis by PCR and by culture on BordetAGengou agar. The infant's serum antibody against pertussis toxin was undetectable. The infant slowly improved with fewer bouts of paroxysmal coughing and she was discharged on hospital day 10. The mother was the only contact who reported cough and was the only contact that was seropositive for pertussis although her culture was negative. Emerging Infectious Diseases.
Title: Pertussis CASE PRESENTATION 1
answer:
True