You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: A 13-year-old girl is operated on due to Hirschsprung illness at 3 months of age. Which of the following tumors is more likely to be present?
Options: <1> Abdominal neuroblastoma <2> Wilms tumor <3> Mesoblastic nephroma <4> Familial thyroid medullary carcinoma.
Solution: 2
Why? The answer to the given question should be a tumor, therefore Wilms tumor is the correct answer for the given question.

New input: Question: To estimate the plasma clearance of a drug (CLIR) that presents a linear kinetic behavior and is excreted significantly in the urine, in a patient with renal failure (RI), it is necessary to know:
Options: <1> Clearance of creatinine in the uremic patient (CLcrIR) and in individuals with normal renal function (CLcrFRN). <2> The renal clearance of the drug in patients with normal renal function (CLrFRN), CLcrIR and CLcrFRN. <3> The fraction of drug excreted in unaltered form in the urine (fr), the dose administered (D), CLrFRN, CLcrIR and CLcrFRN. <4> fr, CLcrIR and CLcrFRN and the plasma clearance of the drug in patients with normal renal function <5> fr, CLrFRN, CLcrIR, CLcrFRN and D.
Solution:
4