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Even transparent objects can impede the infrared signal from your remote. This includes the protective plastic wrap that accompanies new TVs. The infrared sensor is typically in the bottom-right or bottom-left corner of the TV's face. It's easy to forget to change the batteries from time to time, so making sure that your remote's batteries are fresh may improve your remote's performance. You should also be sure to use high-quality batteries (e.g., Duracell or Energizer). If you can get your TV to respond to a different Vizio remote, then you may need to replace or update your current Vizio remote. Similarly, if your malfunctioning Vizio remote actually works with a different TV, the remote isn't the problem. You can do this by calling 1 (855) 833-3221. If your remote simply isn't working, you may be able to get a new one for free. In a pinch, you can also purchase a new remote for your Vizio TV from a local store with a tech department (e.g., Walmart or Best Buy).
Remove any objects from in front of the TV's sensor. Make sure the batteries are new. Use a different Vizio remote with your TV. Contact Vizio customer support.