Information: - Henry I, Prince of Joinville, Duke of Guise, Count of Eu (31 December 1550 23 December 1588), sometimes called "Le Balafre" ("Scarface"), was the eldest son of Francis, Duke of Guise, and Anna d'Este. His maternal grandparents were Ercole II d'Este, Duke of Ferrara, and Renee of France. Through his maternal grandfather, he was a descendant of Lucrezia Borgia and Pope Alexander VI. - Catherine de Cleves (or de Nevers) (1548 11 May 1633) was the wife of Henry, Duke of Guise, and matriarch of the numerous and influential House of Guise. By marriage she was Duchess of Guise from 1570 to 1588, and Dowager Duchess of Guise thereafter. She was Countess of Eu in her own right from 1564. - Charles de Lorraine , 4th Duke of Guise ( 2 August 1571 -- 30 September 1640 ) was the son of Henry I , Duke of Guise and Catherine of Cleves . - The House of Guise was a French noble family, partly responsible for the French Wars of Religion. - Renee of France (25 October 1510 12 June 1574), was the younger surviving child of Louis XII of France and Anne of Brittany. She was the Duchess of Ferrara due to her marriage to Ercole II d'Este, grandson of Pope Alexander VI. In her later life she became an important supporter of the Protestant reformation and ally of John Calvin. What entity does 'charles' has the relation 'noble family' with?
The answer to this question is:
house of guise