In CRPS patients features of central sensitization appear to involve a complex set of neuroinflammatory responses involving NMDA receptors glial cell activation in the spinal cord as well as the release of proinflammatory cytokines from neurons glia and leukocytes

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"In CRPS patients, features of central sensitization appear to involve a complex set of neuroinflammatory responses involving NMDA receptors, glial cell activation in the spinal cord as well as the release of pro-inflammatory cytokines from neurons, glia, and leukocytes.