When Charles's son Philip inherited the duchy, Francis invaded Italy. Philippe de Chabot, a French general, led his army into Piedmont in March 1536, and proceeded to capture Turin the following month, but he failed to seize Milan. In response, Charles invaded Provence, a region of France, advancing to Aix-en-Provence, and took Aix in August 1536 but his movement was halted by the French Army blocking routes to Marseilles. Afterwards, Charles withdrew to Spain rather than attacking the heavily fortified Avignon. There is also a story that French troops deliberately left over-ripe fruit on the trees in an attempt to give Charles's troops dysentery. While Charles V was busy fighting for territory in France, he lost focus on events taking place in Italy. Francis I's armies received massive reinforcements in Piedmont in terms of generals, troops, and horses on a march headed for Genoa. France had secured an alliance with the Ottoman Empire in 1536 through the diplomatic efforts of Jean de La Foret, France's ambassador to the Ottoman Empire. A Franco-Turkish fleet was stationed in Marseille by the end of 1536, threatening Genoa, by planning to attack simultaneously with the French troops marching on land towards the city. Unfortunately for the French and Ottomans, when they arrived in Genoa in August 1536 the defenses of the city had been recently reinforced. Instead, the troops marched onto Piedmont, capturing many towns there. In 1537 Barbarossa raided the Italian coast and laid a siege at Corfu, although this provided only limited assistance to the French. With Charles V unsuccessful in battle and squeezed between the French invasion and the Ottomans, Francis I and Charles V ultimately made peace with the Truce of Nice on 18 June 1538.

Who secured the French alliance with the Ottoman Empire?
A: Jean de La Foret

In the 2015 season opener, the Houston Texans took on the Kansas City Chiefs with Brian Hoyer in his first regular season start as the Texans' quarterback. Hoyer's first pass was intercepted which eventually lead to a Kansas City touchdown. The Chiefs managed to score another 7 points off of turnovers to take a 14-0 lead with 4:28 left in the first. Houston finally managed to get on the board late in the 1st quarter following a 4-yard pass to DeAndre Hopkins from Hoyer. With Randy Bullock missing the extra point the Texans trailed 14-6 with 0:46 left in the 1st. Following another dismal quarter for the Texans, Kansas City lead 27-9 at halftime. Houston managed to shut out the Chiefs for the entire second half and with almost 6 minutes left in the game brought Ryan Mallett in as quarterback, who led the team on two scoring drives. Nonetheless the Texans couldn't manage a comeback and fell to the Chiefs 27-20. This is the first time since 2009 where the Texans lost their season opener. Houston kicker Randy Bullock became the first player to miss a point-after attempt following a rule change for the 2015 season, which requires the ball to be snapped from the 15-yard line.

How many total points were scored in the game?
A: 47

For the final home game of the 2017 season, the Bears hosted the winless Browns on Christmas Eve. In 15 regular season meetings, the Browns led the series 9-6, though the Bears had won the last two games. While the Browns were 0-14, head coach Hue Jackson was 2-0 in Christmas games, including recording the Browns' lone win of 2016 on the day. On offense, protecting Mitchell Trubisky from Gregg Williams' blitz-heavy defense; despite its frequency of utilizing the pass rush, the Browns ranked 29th in quarterback knockdowns with 62, while also allowing ten touchdowns on blitzes. Furthermore, the Browns defense led the league in fewest rushing yards allowed per carry on first down. For the Bears defense, it faced a Browns offense that turned the ball over 36 times, including 19 interceptions from quarterback DeShone Kizer. Entering the game, Chicago had just six interceptions in 2017, meaning Cleveland marked a prime opportunity to increase the stat. The Bears were 6.5-point favorites for the game; in three seasons under John Fox, the Bears had lost all seven games in which they were favored, including defeats to the Packers and 49ers in 2017. In spite of this, considering the Bears' opposition in week sixteen, 247Sports.com's Matt Eurich wrote it would be "satisfying for many to at least see the Bears earn a victory for the first time in three years in which it has been favored." After the first three series ended with punts, Jordan Howard scored on a two-yard run, but Mike Nugent's extra point was blocked. Following five drives that featured three-and-outs, Kizer's pass for Josh Gordon was intercepted by Kyle Fuller, but the Bears were forced to punt. Zane Gonzalez kicked a 48-yard field goal with one second remaining in the first half to make the score 6-3 at halftime. On the first offensive play of the second half, Trubisky was intercepted by Myles Garrett, who returned the pick to the Bears' five-yard line, but the play was called back because of an offsides penalty on Carl Nassib. With the drive saved, Trubisky completed a 40-yard pass to Benny Cunningham to set the offense up in the Browns' red zone, which led to Howard's 16-yard touchdown run. Upon getting the ball back, Trubisky guided the offense downfield on a 66-yard drive that culminated in his four-yard touchdown run. A series later, Rashard Higgins caught Kizer's pass and reached the Bears' three-yard line, where he was stripped by Danny Trevathan and the ball went into the end zone, where Prince Amukamara recovered. Another takeaway for the Bears occurred with 4:11 left in the game, when Kizer's pass was intercepted by Bryce Callahan. However, neither team scored for the rest of the game as the Bears triumphed 20-3. With the win, the Bears defeated all four AFC North teams in 2017, a similar feat accomplished in 2013. Trubisky ran for 246 yards, the most by a Bears quarterback since Kordell Stewart in 2003, along with throwing for 193 yards; the latter increased his season passing yard total to 2,015, the most by a rookie in Bears history.

how many yards did howard run?
A:
16