Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[EX Q]: Paragraph: Shares of the company traded marginally down at $132.47, after having closed up 1.7% on Monday. (bit.ly/2ZkZGze) J&J said that the FTC had issued a "civil investigative demand," or CID, the equivalent of a subpoena to determine if the contracting practices were legal. Pfizer Inc filed a lawsuit against J&J in 2017, saying its rival's contracts with health insurers for blockbuster rheumatoid arthritis drug, Remicade, were anticompetitive and aimed at blocking sales of Pfizer's biosimilar called Inflectra. Pfizer said in the lawsuit that J&J had contracted with many insurers to give discounts in exchange for giving preference to Remicade, and to only pay for Inflectra in cases where Remicade proved to be ineffective. Inflectra was approved in 2016 while Remicade went on the market in 1998. Remicade is an infused treatment for chronic autoimmune disorders and costs about $4,000 per dose, or $26,000 a year, Pfizer said in the lawsuit. J&J has denied any wrongdoing and is fighting the Pfizer lawsuit. Pfizer said in a statement that it had received a CID in June. "As Pfizer's complaint alleges, J&J's unlawful conduct is designed to prevent Inflectra from being able to compete on its primary point of differentiation price. Today, Inflectra has an average selling price (ASP) that is more than 22% lower than Remicade," the company said in a statement. "Despite these facts, J&J has not lost substantial volume or share of sales counter to what should occur in a competitive market." Biosimilars are intended to be lower-cost alternatives to expensive biotech medicines. But since they are made from living cells and it is not possible to make an exact copy of the branded medicine, they are not automatically substituted for the existing branded drug the way a generic drug would be. The drugs treat ailments like rheumatoid arthritis, Crohn's disease and ulcerative colitis. Claim: J&J says FTC probing efforts to protect arthritis drug Remicade.
[EX A]: The Federal Trade Commission issued civil subpoenas to Johnson and Johnson in June as part of an investigation into whether contracting practices for its blockbuster rheumatoid arthritis drug, Remicade, violated antitrust laws, the company said in a regulatory filing on Monday.

[EX Q]: Paragraph: "Ed Stafford of Leicestershire, England walks in between trees as he walks through the Amazon jungle in Brazil in this undated handout photo. Former British army captain Stafford became on Monday the first known person to walk from the origin of the Amazon river, the world's second-longest river, to its mouth, after withstanding ""50,000"" mosquito bites, scorpion attacks and skin disease in his 859 day odyssey. REUTERS/Handout Ed Stafford, a 34-year-old from Leicestershire, England, dived into the Atlantic Ocean after taking 859 days to walk the length of the world's second-longest river, starting at the peak of Mount Mismi in Peru in April 2008. "It's just phenomenal to be here at the end of the journey after 2-1/2 years slogging our way through the jungle," he told Reuters after arriving at the beach about 90 miles northeast of the Brazilian city of Belem. "It was really difficult to envisage how this was going to feel and I'm completely overwhelmed." Stafford briefly collapsed from exhaustion with only 52 miles of the 6,000-mile journey to go, passing out by the roadside after breaking out in a rash. "I feel slightly humbled that my system just decided to shut down so close to the finish," he wrote on his blog at www.walkingtheamazon.com. Stafford has aimed to use the walk to raise awareness about the threats to the Amazon rain forest and its people, using a portable satellite video to blog about his trek. He had planned to complete the walk in about a year, but the journey was prolonged by floods that forced him to walk a roundabout route that was 2,000 miles longer than the 4,000-mile (6,400-km) length of the Amazon, which is exceeded in length only by Africa's Nile river. He began the journey with fellow British adventurer Luke Collyer, but the pair had a falling out early in the trek and Stafford continued alone. He was joined in July 2008 by a Peruvian forestry worker, Gadiel Cho Sanchez Rivera, who pledged to walk with him for five days and has been with him on the walk ever since. A statement from Stafford's media team said that the Briton had been: "wrongly accused of murder on two separate occasions, been imprisoned, had concrete stuffed in his mouth by hostile tribes people, been chased by Ashaninka Indians with bows and arrows, been stung by hundreds of wasps and watched as his guide 'Cho' removed a botfly from Ed's head with superglue and a tree spine." It said he had endured "50,000" mosquito bites, lived on a diet of piranha fish, rice and beans, and dodged a variety of snakes, electric eels, scorpions, and ants, as well as contracting a skin-disfiguring disease. Famed British explorer Sir Ranulph Fiennes was quoted as saying in the statement that Stafford's feat was "truly extraordinary." "No one has ever done this before and the pundits considered the route impossible," he said." Claim: British man becomes first to walk Amazon length.
[EX A]: A former British army captain became on Monday the first known person to walk from the origin of the Amazon river to its mouth, after enduring "50,000" mosquito bites, attacks by hostile Indians and tropical disease in his nearly 2-1/2 year odyssey.

[EX Q]: Paragraph: Biogen had announced in March that it would terminate two large clinical trials of aducanumab because they were likely to fail. Within weeks, a group of company researchers set out to understand what went wrong. As they studied data from a larger pool of patients who received the drug, they began to question that conclusion. In the months that followed, Biogen kept its own trial investigators and committee overseeing the trial in the dark about the possibility that some patients had benefited from high doses of the therapy, researchers told Reuters. The company said it brought in outside Alzheimer's experts and statisticians to help it parse the new findings, and sought feedback from U.S. regulators on whether it could be considered for approval. The result, made public on Tuesday, was an astounding reversal. Biogen will seek U.S. approval for the therapy early next year, once again raising hopes for patients suffering from the brain-wasting disease. Biogen shares gained 27% on investor hopes for a multibillion-dollar blockbuster. The risks for Biogen remain high. Wall Street analysts cast doubt on whether Biogen's analysis would pass muster with the U.S. Food and Drug Administration without an additional years-long trial to confirm the findings. Several Alzheimer's researchers questioned why one trial appeared to succeed, while another with the same design failed. Many experts say they are reserving judgment until Biogen presents more detailed data in December. Company executives are reluctant to characterize their interactions with the FDA, but said they worked closely with the agency until they were confident in the findings. Biogen was only willing to move forward with seeking approval for aducanumab after meeting twice with FDA. The final decision was made immediately after the second of those meetings, which took place on Monday, Biogen officials said. For the FDA "to say it's reasonable to file an application after two extensive discussions with them, formal meetings as well as a number of informal discussions, I think it's significant," Biogen research chief Al Sandrock said in an interview. Biogen's earlier decision to terminate the trials was viewed as the final nail in the coffin for the so-called "amyloid hypothesis" - the theory that removing a protein associated with Alzheimer's could stave off this fatal form of dementia. Many similar drugs had previously failed. Globally, 131 million people are expected to be diagnosed with Alzheimer's by 2050, up from 50 million today. Any successful treatment could be worth $10 billion or more in annual sales, industry analysts say. The March announcement also raised concerns about a second therapy, BAN2401, that works in a similar way. Biogen is partnering with Japan's Eisai on both drugs. Ivan Cheung, Eisai's chief executive, said in an interview that he expects aducanumab's revival will energize enrollment in a late-stage study of BAN2401, with results expected in 2022. Patients taking the highest dose of BAN2401 showed some encouraging results in a midstage trial last year. "That's why in the Phase III trial, we are only studying the highest dose," Cheung said. The two aducanumab trials - Engage and Emerge - started a month apart in 2015. Each had about 1,640 patients. As they progressed, the company made changes in the trial that expanded the number of patients who received a higher dose. As part of a planned "futility analysis," outside monitors reviewed half of the data as of December 2018 to determine whether the drug had a reasonable chance of success. "So many of us felt that this might be the drug that would cross the finish line," said Dr. Sharon Cohen, director of the Toronto Memory program, who led one of the studies. In March, she received the answer: the therapy looked like a dud. However, patients continued to receive treatment in the interim. Cohen believes the fact that some patients got a higher dose for longer helped swing results in the Emerge study, which ultimately showed a benefit. A month after announcing the failure, Biogen began analyzing results from both trials, including additional data from patients who later completed treatment. By the time Biogen had its first FDA meeting in mid-June, the company knew that one of the studies had succeeded, and understood that dose was important, said Samantha Budd Haeberlein, who runs Biogen's Alzheimer's program. "We did a great deal of analysis in close contact with the FDA to really understand what occurred in these trials," Haeberlein said. "It took several months to work through that." During that entire stretch, Cohen said she and fellow investigators were waiting to hear why the drug had failed. They expected a presentation in July during the Alzheimer's Association annual meeting, but none came. "I was completely unaware of what had been discovered until last Sunday," said Dr. Anton Porsteinsson, a principal investigator for the trials from the University of Rochester School of Medicine and Dentistry. Porsteinsson said Biogen asked him to sign a non-disclosure agreement before sharing the new analysis. Cohen said she first reviewed the new data on Monday in what she called a "top secret" meeting. She said the company wanted a few investigators to hear the findings ahead of Tuesday's announcement, but had concerns about insider trading. Many still question why only one trial succeeded. "The signal from the positive trial was kind of convincing," said Mayo Clinic Alzheimer's expert Dr. Ronald Petersen, who has been a paid adviser for Biogen. It showed a 23% reduction in a key measure of cognitive decline. "But the other study, which was meant to be identical, didn't show it," he said. "That's the challenge there." Claim: Austin is number one in Texas in startups, venture capital and patents.
[EX A]:
Biogen Inc's (BIIB.O) shock decision this week to bring its experimental Alzheimer's drug back from the scrap heap was born out of "top secret" meetings, non-disclosure agreements and six months of hashing over trial data with scientists, regulators and statisticians, researchers told Reuters.