In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
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Question: Paragraph: The field of viral molecular biology has reached a precipice for which pioneering studies on the structure of viral RNAs are beginning to bridge the gap. It has become clear that viral genomic RNAs are not simply carriers of hereditary information, but rather are active players in many critical stages during replication. Indeed, functions such as cap-independent translation initiation mechanisms are, in some cases, primarily driven by RNA structural determinants. Other stages including reverse transcription initiation in retroviruses, nuclear export and viral packaging are specifically dependent on the proper 3-dimensional folding of multiple RNA domains to recruit necessary viral and host factors required for activity. Furthermore, a large-scale conformational change within the 5-untranslated region of HIV-1 has been proposed to regulate the temporal switch between viral protein synthesis and packaging. These RNA-dependent functions are necessary for replication of many human disease-causing viruses such as severe acute respiratory syndrome (SARS)-associated coronavirus, West Nile virus, and HIV-1. The potential for antiviral development is currently hindered by a poor understanding of RNA-driven molecular mechanisms, resulting from a lack of structural information on large RNAs and ribonucleoprotein complexes. Herein, we describe the recent progress that has been made on characterizing these large RNAs and provide brief descriptions of the techniques that will be at the forefront of future advances. Ongoing and future work will contribute to a more complete understanding of the lifecycles of retroviruses and RNA viruses and potentially lead to novel antiviral strategies.
Title: Progress and outlook in structural biology of large viral RNAs NIH Public Access

Answer: True

Question: Paragraph: The yeast two-hybrid (Y2H) system is a powerful method to identify and analyze binary protein interactions. In the fi eld of virology, the Y2H system has signifi cantly increased our knowledge of structure and function of viral proteins by systematically assessing intraviral protein interactions. Several comprehensive approaches to determine virus-host interactions have provided insight into viral strategies to manipulate the host for effi cient replication and to escape host-derived countermeasures. To expand our knowledge of intraviral and virus-host protein interactions, we here present a Y2H protocol that is well suited for high-throughput screening. Yeast mating followed by liquid handling in a 96-well format as well as fl uorescent readout of the reporter system provides a highly standardized and fully automated screening situation. The protocol can either be applied to screen complex host cDNA libraries or protein pairs arrayed for cross-testing. The ease of use, the cost-effectiveness as well as the robotic handling allows for extensive and multiple rounds of screening providing high coverage of protein-protein interactions. Thus, this protocol represents an improved "deep" screening method for high-throughput Y2H assays.
Title: Chapter 1 A High-Throughput Yeast Two-Hybrid Protocol to Determine Virus-Host Protein Interactions

Answer: True

Question: Paragraph: A 69-year-old male with a past medical history of hypertension, diabetes mellitus, and acute myelogenous leukemia (AML) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) presented with recurrent fever and cough. The patient had undergone allogeneic HSCT from a matched unrelated donor 17 months previously, conditioned by fludarabine, melphalan, and alemtuzumab. His posttransplant course was complicated by graft versus host disease and multiple central venous catheter infections with coagulase-negative Staphylococcus spp., vancomycinresistant Enterococcus, Lactobacillus, and alpha-hemolytic Streptococcus. During his initial course, he also developed a nodular pneumonia, and the subsequent workup included a bronchoscopy that was nondiagnostic. The pneumonia resolved with empiric posaconazole treatment. Sixteen months after the transplant, the patient developed fatigue, low-grade fevers, and cough. Chest x-ray (CXR) showed a new, left lower lobe infiltrate. A sputum culture then grew fluoroquinolone-susceptible Pseudomonas, and the Oncology Service subsequently discharged the patient home on moxifloxacin alone. Three weeks later, he presented again with recurrent cough and fever and was readmitted. A CXR showed a new, right lower lobe infiltrate. The patient had a remote history of symptomatic bradycardia for which he had undergone pacemaker placement. He was a former cigarette smoker (40 pack-years), but he denied any intravenous drug use. He was a retired automobile mechanic and lived at home with his wife and a dog. He had traveled recently to Las Vegas for a short trip to visit casinos. His medications on admission included acyclovir, fluconazole, and dapsone prophylaxis. He previously had an adverse reaction to imipenem, which caused a rash, and to voriconazole, which caused visual hallucinations. On physical examination, he was alert and oriented. His temperature was 100.5 F, heart rate 86 beats per minute, blood pressure 134/94 mmHg, respiratory rate 20 breaths per minute, and oxygen saturation 90% on ambient air. He had mild bilateral crackles at the lung bases and a well-healed, non-tender, nonerythematous surgical scar at the site of the pacemaker pocket on the anterior chest wall. The remainder of his physical examination was unremarkable. Laboratory values were significant for pancytopenia, with WBC count of 3500/l, (76% neutrophils, 8% lymphocytes, and 12% monocytes), hemoglobin 11.6 g/dL (normal range, 13.5-17.5 g/ dL), and platelet count of 122,000/L (normal range, 150,000-450,000/L). Other laboratory
Title: Pulmonary Infection in a Patient After Stem Cell Transplantation

Answer:
False