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This will give the Alka-Seltzer time to remove any residue or stains from the bottle. It's a good idea to leave the bottle in your sink to ensure you don't wake up to a mess the next morning. Set the bottle upside down in a dish drainer or on a towel. Prop it up if needed to keep the bottle from falling or breaking. After a few hours, flip the bottle over and allow it to dry completely.
Allow the mixture to set overnight. Air-dry the bottle.