In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Input: Consider Input: Question: In general, allosteric enzymes:
Options: <1> They link the effectors in the active center. <2> They form covalent bonds with their negative effectors. <3> They originate hyperbolic curves of speed before the concentration of substrate. <4> They change their conformation when they link effectors. <5> They are irreversibly modified when they are inhibited.

Output: 4

Input: Consider Input: Question: What serum immunoglobulin will synthesize an activated B lymphocyte that has not been stimulated through CD40 ?:
Options: <1> Any. <2> IgE <3> IgM <4> IgA <5> IgG

Output: 3

Input: Consider Input: Question: Activates the renin-angiotensin aldosterone system an increase in:
Options: <1> Blood pressure. <2> Parasympathetic activity <3> Concentration of Ca2 + in plasma. <4> Na + concentration in plasma. <5> Sympathetic activity
Output: 5