Here is a premise:
The first possibility is that the number of instances will need to be fairly large in order to achieve the generalizability wanted, and, as a consequence, skill will be needed to manage data collection with sufficient flexibility to obtain the insights case studies offer and sufficient structure to permit cross-site aggregation of findings.

Here is a hypothesis:
There only needs to be a small number of instances for the generalizability wanted.

Is it possible to conclude that if the premise is true, then so is the hypothesis?
no