Q:Information: - Nevus anemicus is a congenital disorder characterized by macules of varying size and shape that are paler than the surrounding skin and can not be made red by trauma , cold , or heat . The paler area is due to the blood vessels within the area which are more sensitive to the body 's normal vasoconstricting chemicals . - A birthmark is a congenital, benign irregularity on the skin which is present at birth or appears shortly after birth, usually in the first month. They can occur anywhere on the skin. Birthmarks are caused by overgrowth of blood vessels, melanocytes, smooth muscle, fat, fibroblasts, or keratinocytes. - Nevus (plural: nevi) is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. The term originates from "nvus", which is Latin for "birthmark," however, a nevus can be either congenital (present at birth) or acquired. Common terms, including mole, birthmark, and beauty mark, are used to describe nevi, but these terms do not distinguish specific types of nevi. - A lesion is any abnormal damage or change in the tissue of an organism, usually caused by disease or trauma. "Lesion" is derived from the Latin word "laesio" meaning "injury". Lesions may occur in plants as well as animals. - Skin is the soft outer covering of vertebrates. Other animal coverings, such as the arthropod exoskeleton have different developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin "cutis", skin). In mammals, the skin is an organ of the integumentary system made up of multiple layers of ectodermal tissue, and guards the underlying muscles, bones, ligaments and internal organs. Skin of a different nature exists in amphibians, reptiles, and birds. All mammals have some hair on their skin, even marine mammals like whales, dolphins, and porpoises which appear to be hairless. The skin interfaces with the environment and is the first line of defense from external factors. For example, the skin plays a key role in protecting the body against pathogens and excessive water loss. Its other functions are insulation, temperature regulation, sensation, and the production of vitamin D folates. Severely damaged skin may heal by forming scar tissue. This is sometimes discoloured and depigmented. The thickness of skin also varies from location to location on an organism. In humans for example, the skin located under the eyes and around the eyelids is the thinnest skin in the body at 0.5mm thick, and is one of the first areas to show signs of aging such as "crows feet" and wrinkles. The skin on the palms and the soles of the feet is 4mm thick and the back is 14mm thick and is the thickest skin in the body. The speed and quality of wound healing in skin is promoted by the reception of estrogen. Given the information above, choose from the list below the object entity that exhibits the relation 'instance of' with the subject 'nevus anemicus'. Choices: - animal - change - chemical - composition - damage - disease - location - may - month - organism - production - quality - regulation - skin - system - term - tissue - water - word
A:
disease