Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2 or 3 were synthesized. A majority of them showed a modest anti-HIV-1 activity, whereas 2-adamantan-1-yl-3-(4,6-dimethylpyrimidin-2-yl)-thiazolidin-4-one (8) was endowed with a remarkable antiviral potency (EC 50 0.67 mM). The new series of compounds (22e29) with an adamantyl moiety at the 3-position of the thiazolidinone ring showed good to modest anti-HIV-1 activity (EC 50 1.0e11 mM) but also pronounced cytostatic activity. For example 24, 26 and 29 showed an EC 50 of 1.0e2.0 mM, while the 50% effective concentrations for 23 and 28 were 7.8 and 11.0 mM, respectively. X-ray studies and quantum chemical calculations revealed that the anti-HIV activity of the compounds strongly depends on their dipole moments and conformation of the thiazolidinones.
Output:
Synthesis and anti-HIV studies of 2-and 3-adamantyl-substituted thiazolidin-4-ones