Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Input: Consider Input: Abstract: One hundred twelve patients who developed acute leukemia or a myelodysplastic syndrome (MDS) after chemotherapy or irradiation for another malignancy were reviewed. The median time from initial therapy to development of secondary leukemia or MDS was 71 months (range, 7 to 331 months). The initial malignancy was hematologic in 43%. An MDS presentation occurred in 57 patients (51%), 55% of whom subsequently transformed to acute leukemia. Chromosomal abnormalities were documented in marrow specimens from 70 of 89 patients with analyzable metaphases (79%; 69% of the total group). Compared with 34 patients with metachronous secondary leukemia without prior chemotherapy or irradiation, those with therapy-related leukemia exhibited a significantly higher frequency of abnormalities of chromosomes 5 and/or 7 (43% v 18%), and lower incidence of diploid karyotypes (18% v 50%). Chromosome 5 and/or 7 abnormalities were also significantly higher in patients previously treated with alkylating agents, procarbazine, and nitrosoureas (72% to 83%), compared with those who had received cyclophosphamide-based regimens (29%), other chemotherapies (14%), or irradiation alone (29%). The median overall survival from diagnosis of the secondary leukemia or MDS was 30 weeks. Survival was significantly shorter for patients with acute leukemia compared with MDS presentation (21 v 45 weeks); in the latter category, it was similar whether evolution to acute leukemia occurred or not. Of 72 patients treated with antileukemia therapy, 29% achieved complete remission (CR). A multivariate analysis of prognostic factors demonstrated the cytogenetic pattern to be the most important characteristic determining remission rate and survival. Other important prognostic features were the morphologic presentation (MDS v acute leukemia) for probability of achieving remission, and patient age and marrow blasts percentage for survival.
Which is the apt title for the abstract? option1: Therapy-related leukemia and myelodysplastic syndrome: clinical, cytogenetic, and prognostic features. option2: TGA criteria: what's in a name? [letter]

Output: Therapy-related leukemia and myelodysplastic syndrome: clinical, cytogenetic, and prognostic features.

Input: Consider Input: Abstract: A retrospective review of hospital records for 333 patients admitted to a large community teaching hospital by family physicians and family practice residents was performed to determine whether teaching programs in family practice led to a significant increase in the cost of care to patients. Three patient populations were identified for comparison: patients admitted by private family physicians when residents were not involved in patient care, patients admitted by the same family physicians while they served as attending physicians on the family practice service and allowed residents to participate in the care of their patients, and patients admitted by residents from the patient population at the Family Practice Center. After taking into account differences in case mix, an analysis of laboratory charges, radiology use, frequency of procedures, and use of consultants showed that the three groups were not different. Family practice residents managed their own patients as cost effectively as physicians in private practice, which suggests that experience alone is not necessary to develop methods of cost-efficient care. When these two groups were combined into a teaching unit, with few exceptions this efficiency was maintained. These results imply that the introduction of family practice residents into patient care does not invariably increase expenses to the patient.
Which is the apt title for the abstract? option1: The influence of a family practice residency on the costs of inpatient diagnostic testing. option2: Primary leptomeningeal glioma mimicking an acoustic neuroma: case report with review of the literature.

Output: The influence of a family practice residency on the costs of inpatient diagnostic testing.

Input: Consider Input: Abstract: This report describes the nuclear cardiology procedures available for use as diagnostic techniques in patients with definite or suspected cardiovascular disease. The usefulness of myocardial imaging, radionuclide angiocardiography and other radionuclide cardiovascular imaging techniques is classified within specific disease states. The clinical utility of each technique is graded from I to IV, depending on the clinical importance of the technique (I = most important; IV = not indicated). A grade of V is given for methods now considered to be in their research phase. The usefulness of these methods is discussed in patients with acute ischemic heart disease, chronic ischemic heart disease, valvular heart disease, pulmonary vascular disease and hypertensive heart disease. Selected references are provided.
Which is the apt title for the abstract? option1: Guidelines for Clinical Use of Cardiac Radionuclide Imaging, December 1986. A report of the American College of Cardiology/American Heart Association Task Force on Assessment of Cardiovascular Procedures (Subcommittee on Nuclear Imaging). option2: Calcium carbonate as a phosphate binder [letter]
Output: Guidelines for Clinical Use of Cardiac Radionuclide Imaging, December 1986. A report of the American College of Cardiology/American Heart Association Task Force on Assessment of Cardiovascular Procedures (Subcommittee on Nuclear Imaging).