TASK DEFINITION: Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).
PROBLEM: Abstract: A patient who presented with multiple episodes of subarachnoid hemorrhage was diagnosed as having a large mid-basilar artery aneurysm that had no definable surgical neck. Balloon embolization was performed utilizing two detachable silicone balloons to occlude the mid-basilar artery and the aneurysm. The procedure was carried out with the patient fully awake and alert. One day after the procedure, the patient developed pontine and cerebellar ischemia which completely resolved after 5 days on heparin therapy. A follow-up angiogram performed immediately after the procedure and at 3 months demonstrated complete occlusion of the mid-basilar artery and the aneurysm. The patient was intact neurologically upon discharge 5 days after the embolization procedure and has since resumed his normal activities. Balloon embolization therapy may offer some advantages over surgical methods for the treatment of such therapeutically challenging aneurysms.
Which is the apt title for the abstract? option1: Intravascular balloon embolization of a large mid-basilar artery aneurysm. Case report. option2: Erb/Duchenne's palsy: a consequence of fetal macrosomia and method of delivery.

SOLUTION: Intravascular balloon embolization of a large mid-basilar artery aneurysm. Case report.

PROBLEM: Abstract: Between January 1979 and June 1985, 10 patients with acute allergic interstitial nephritis were seen in a clinical nephrology service at a large regional hospital. The onset of renal failure was temporally related to the use of a drug: a nonsteroidal anti-inflammatory agent (NSAID) (in four patients), cimetidine (in three), antibiotics (in two) or allopurinol (in one). The onset of renal failure was acute in three patients and insidious in seven. Two patients also exhibited marked proteinuria. Clinical features such as fever, rash, hematuria, pyuria with or without eosinophiluria, and mild to marked proteinuria had led to suspicion of the disease. The diagnosis was confirmed by renal biopsy findings of inflammatory cells, predominantly lymphocytes, plasma cells and eosinophils. Three patients required hemodialysis; two of them received steroids as well. Steroid therapy was also used in two patients with NSAID-induced proteinuria. Renal function improved in nine patients by 35 days, but one patient continued to have slow but progressive deterioration of renal function. Acute interstitial nephritis can be distinguished from other forms of acute renal failure by heavy renal uptake of gallium 67, maximal 48 hours or more after injection. The improvement in renal function after discontinuation of the implicated drug, the characteristic histopathological findings of allergic interstitial nephritis, and the presence of eosinophils and sometimes IgE in the blood suggest a hypersensitivity reaction.
Which is the apt title for the abstract? option1: Drug-induced acute interstitial nephritis: report of 10 cases. option2: The American Dietetic Association's nutrition recommendations for women.

SOLUTION: Drug-induced acute interstitial nephritis: report of 10 cases.

PROBLEM: Abstract: The role of the second messengers cAMP and Ca++ in the control of proopiomelanocortin (POMC) gene expression was investigated with the use of hybridization with cloned complementary DNA probes. The effects of cAMP-related drugs on POMC messenger RNA (mRNA) levels were assessed in primary cultures of intermediate (IL) and anterior rat pituitary cells maintained in serum-free medium. 8-Bromo-cAMP (1 mM), but not 8-bromo-cGMP (1 mM), induced a 2-fold increase in IL and anterior lobe cell after 2 days of treatment. A similar increase was obtained with the adenylate cyclase-activating drugs forskolin (1 microM) and cholera toxin (100 ng/ml) or the phosphodiesterase inhibitor RO 20-1724 (100 microM). At 48 h, all these treatments had increased beta-endorphin accumulation in the medium and transiently decreased the cellular beta-endorphin content in IL cells, suggesting a parallel effect of cAMP-related drugs on secretion and biosynthesis. Incubating the cells with the Ca++ channel antagonists D600 (50 microM), verapamil (50 microM), and the dihydropyridine nifedipine (0.1 microM) decreased basal POMC mRNA levels, whereas the dihydropyridine BAYK 8644 (0.1 microM), which activates the Ca++ channel, increased POMC mRNA levels after 2 days. In addition, nifedipine decreased the stimulatory effect of forskolin, whereas BAYK 8644 further stimulated the forskolin-increased POMC mRNA levels in IL cells. We conclude that both Ca++ and cAMP may regulate the gene expression of POMC.
Which is the apt title for the abstract? option1: Calcium ion and cyclic adenosine 3',5'-monophosphate regulate proopiomelanocortin messenger ribonucleic acid levels in rat intermediate and anterior pituitary lobes. option2: Natural history of postoperative aneurysm rests.

SOLUTION:
Calcium ion and cyclic adenosine 3',5'-monophosphate regulate proopiomelanocortin messenger ribonucleic acid levels in rat intermediate and anterior pituitary lobes.