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Use a cloth lightly dampened with your chosen cleanser to wipe the stained area. Drag the dampened cloth over the area gently; you do not want to scrub the leather. Be sure to wipe the entire surface of the stained area from edge to edge, seam to seam. It's important to clean the entire surface, since you could leave a new stain on the leather if you just clean a specific area. It's better to dampen and clean the entire section of the leather cushion, rather than only treat the stained area. If you want to make your own cleaning solution, mix together 1 US quart (0.95L) of hydrogen peroxide, cup (58 g) of baking soda, and 1 tablespoon (15mL) of liquid dish soap. Gently combine these ingredients together in a bowl. Dip your cloth into the solution and wring it out. You can also use white vinegar as a natural alternative to hydrogen peroxide. Vinegar can help disinfect and deodorize the stained surface. Since the stuffing may be saturated with urine, you need to use an enzymatic cleaner to remove the urine and dispel the urine's potent, chemical odor. Wash the stuffing as you would wash any kind of clothing by hand, in a large sink or tub. Apply the enzymatic cleanser to the stuffing and use your hands to work the cleaning solution into the urine-saturated area. Squeeze the stuffing and rinse it with clean, running water. Do this many times to be sure you completely rinse out and neutralize the urine stain and odor. Allow the stuffing to dry naturally outside. If the stuffing can dry outside in sunlight, that may help get rid of the urine smell even more. Insert the stuffing back into the leather cushion once the stuffing and cushion are both completely dry. Do your best to reposition the stuffing how it was in the cushion originally, and zip the cushion shut again. After the leather has fully dried, apply a leather conditioner to the leather surface. Apply a small amount of conditioner to a soft rag, and use the rag to wipe the entire surface of the leather. Be sure to coat all sides of the leather cushion. A leather conditioner will ensure that your leather stays soft and supple, replenishing any of the natural oils that the cleaning solution may have removed from the surface.
Clean the leather surface. Wash the stuffing. Reinsert the stuffing. Condition the leather.