Premise: Now, don't get offended, Miss er Cowley.

Hypothesis: "Miss Cowley, try not to get offended"
Answer: yes

Premise: This makes the book subclass very inefficient at serving those for whom it was established.

Hypothesis: This is because it was not written well.
Answer: it is not possible to tell

Premise: According to Time , dopamine explains how and why we become addicted to sex, drugs, booze, gambling, food, cheap thrills, and yes, tobacco.

Hypothesis: Time denies that dopamine shows why we form addictions.
Answer: no

Premise: Made of ...

Hypothesis: Not made using.
Answer: no