instruction:
Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.
question:
It is often suggested that immigrants with long-term pain do not benefit from rehabilitation to the same extent as native Swedish patients. In this study, an 8-week rehabilitation programme was evaluated according to its adaptation for immigrants.', "To establish whether there is a difference between immigrants and native Swedes concerning: (i) return-to-work, the patients' own estimation and their actual ability; (ii) higher level of activity; (iii) reduction in pain and analgesic use.", 'A total of 67 patients with persistent non-malignant pain completed the rehabilitation programme. Thirty (45%) of the patients were immigrants.', 'A 1- and a 3-year follow-up were made to compare the outcome between the 2 groups.', "There was no significant difference in the return-to-work rate between immigrants and native Swedes. However, the patients' prediction of their ability to return to work was higher among the non-immigrants. The level of activity was lower and pain intensity and use of analgesics were higher among the immigrants than the non-immigrants.
answer:
1

question:
The B cell is a key player in the pathogenesis of systemic lupus erythematosus (SLE). Loss of B cell tolerance resulting in autoantibody production and immune complex formation and deposition are central features of the disease. B cell overactivity is a hallmark of SLE and molecular abnormalities in B cell signaling cascade have been described.', 'In this review, we will focus on the aberrant phenotype of B cell signaling in patients with lupus. We will also discuss data stemming from the use of small molecules that have recently been recognized to target important steps of the B cell signal transduction pathways with therapeutic implications for SLE.
answer:
0

question:
Oxidative stress has been reported to be a main cause of neuronal cell death in ischemia reperfusion injury (IRI). Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important factor involved in anti-oxidative responses. We previously reported that bardoxolone methyl (BARD), an Nrf2 activator, prevented damage induced by IRI. In this study, we investigated the effect of BARD on hemorrhagic transformation in the context of blood brain barrier (BBB) protection.', 'Mice received pre-treatment with warfarin (4.0 mg/kg, p.o.). IRI was subsequently induced 18 h after the warfarin administration by transient middle cerebral artery occlusion (MCAO) for 6 h. BARD (0.06, 0.2, 0.6 or 2.0 mg/kg) or saline was injected intravenously immediately after reperfusion. The infarct volume, neurological score, intracranial hemorrhage volume, and BBB permeability were evaluated 24 h after MCAO. The survival rate and behavioral functional recovery were evaluated for 7 days following IRI. Furthermore, the effects of BARD on BBB components were investigated by western blotting and immunostaining analysis.', 'BARD suppressed warfarin-mediated increases in the intracranial hemorrhage volume without affecting the infarct volume. BBB permeability was also suppressed by administration of BARD. Western blotting showed that BARD increased expression of BBB components such as endothelial cells, pericytes, and tight junction proteins. Furthermore, immunostaining showed that BARD induced localization of Nrf2 to endothelial cells and pericytes.
answer:
1