Detailed Instructions: Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Problem:Context: To date, studies with ingenol mebutate gel have used clinical clearance, not histological clearance, as a primary efficacy endpoint.', 'This phase I, multicentre, single-arm, open-label study sought to confirm histologically the clinical clearance of actinic keratoses (AKs) to support a treatment effect deep in the epidermis.', 'Patients (n = 108) aged 18 years with histologically confirmed AK within a 25-cm', 'The observed agreement rate between clinical and histological assessments of clearance of a single AK was 819% and the positive predictive value of a clinical assessment of clearance was 87%. Agreement between the two pathologists was 88%. The common composite 8-week complete clearance rate was 41% (95% confidence interval 32-50). Observed agreement rates between RCM and pathologist I and II assessments of clearance were 729% and 814%, respectively. Overall, 30 patients (278%) experienced 38 adverse events (AEs). Application-site pain (four patients, 37%) was the most common treatment-related AE inside the treatment area.
Answer: Ingenol mebutate achieves histopathological clearance of AKs that correlates with observed clinical clearance. Clinical clearance is a good predictor for histological clearance.
Solution:
Does histological examination confirm clinical clearance of actinic keratoses following treatment with ingenol mebutate 005 % gel?