Q: In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.
Context: Managing aggressive breast cancers with enhanced chromosomal instability (CIN) is a significant challenge in clinics. Previously, we described that a cell cycle-associated kinase called Tousled-like kinase 2 (TLK2) is frequently deregulated by genomic amplifications in aggressive estrogen receptor-positive (ER\Question: Does amplification of TLK2 induce Genomic Instability via Impairing the G2-M Checkpoint?
A:
Targeting TLK2 presents an attractive therapeutic strategy for the TLK2-amplified breast cancers that possess enhanced genomic instability and aggressiveness. Mol Cancer Res; 14(10); 920-7. ©️2016 AACR.