Ehrlich's approach of systematically varying the chemical structure of synthetic compounds and measuring the effects of these changes on biological activity was pursued broadly by industrial scientists, including Bayer scientists Josef Klarer, Fritz Mietzsch, and Gerhard Domagk. This work, also based in the testing of compounds available from the German dye industry, led to the development of Prontosil, the first representative of the sulfonamide class of antibiotics. Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful for infections caused by pathogens such as streptococci. In 1939, Domagk received the Nobel Prize in Medicine for this discovery. Nonetheless, the dramatic decrease in deaths from infectious diseases that occurred prior to World War II was primarily the result of improved public health measures such as clean water and less crowded housing, and the impact of anti-infective drugs and vaccines was significant mainly after World War II.
What causes Streptococci?
pathogens

The northern side of Miami includes Midtown, a district with a great mix of diversity with many West Indians, Hispanics, European Americans, bohemians, and artists. Edgewater, and Wynwood, are neighborhoods of Midtown and are made up mostly of high-rise residential towers and are home to the Adrienne Arsht Center for the Performing Arts. The wealthier residents usually live in the northeastern part, in Midtown, the Design District, and the Upper East Side, with many sought after 1920s homes and home of the MiMo Historic District, a style of architecture originated in Miami in the 1950s. The northern side of Miami also has notable African American and Caribbean immigrant communities such as Little Haiti, Overtown (home of the Lyric Theater), and Liberty City.
What notable theater is present in Overtown?
Lyric

When the war began, the French government ordered a blockade of the North German coasts, which the small North German navy (Norddeutsche Bundesmarine) with only five ironclads could do little to oppose. For most of the war, the three largest German ironclads were out of service with engine troubles; only the turret ship SMS Arminius was available to conduct operations. By the time engine repairs had been completed, the French fleet had already departed. The blockade proved only partially successful due to crucial oversights by the planners in Paris. Reservists that were supposed to be at the ready in case of war, were working in the Newfoundland fisheries or in Scotland. Only part of the 470-ship French Navy put to sea on 24 July. Before long, the French navy ran short of coal, needing 200 short tons (180 t) per day and having a bunker capacity in the fleet of only 250 short tons (230 t). A blockade of Wilhelmshaven failed and conflicting orders about operations in the Baltic Sea or a return to France, made the French naval efforts futile. Spotting a blockade-runner became unwelcome because of the question du charbon; pursuit of Prussian ships quickly depleted the coal reserves of the French ships.
In pursuing Prussian ships, what resource was quickly depleted?
coal reserves