TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Mowat-Wilson syndrome (MWS) is characterized by severe mental retardation with seizures, specific facial dysmorphism, Hirschsprung disease, anomalies of the corpus callosum, and genitourinary and cardiac malformations. The cause of MWS is a de novo mutation in the ZEB2 gene. This report describes a Turkish boy who was clinically diagnosed with MWS and had his diagnosis confirmed by molecular analysis of the ZEB2 gene. The investigation identified a heterozygous complex rearrangement in exon 8 of ZEB2, specifically a 48-nucleotide deletion and a 44-nucleotide insertion that caused a frameshift. MWS is a relatively newly identified disorder, and even MWS patients without Hirschsprung disease can be diagnosed easily based on clinical findings alone.
Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?

SOLUTION: zeb2

PROBLEM: Context: Long long ago, there was an old merchant who had three sons. "To which one shall I leave my fortune?" he wondered. "It must be to the cleverest son. But which one is the cleverest?" He called his three sons to him. "Here is some money," he told them, "you must each take one coin to buy something that will fill this room. Anyone who can do this shall have my fortune." "It is a big room," said the eldest son. "One coin will not buy very much," said the second son. But the youngest son said nothing. He stood and thought, and then he smiled, "Come, brothers," he said, "let us go to the market." The eldest son bought straw with his coin. But one coin bought only a bit of straw. Even when he had spread it as much as he could, the straw covered only a corner of the room. The second son bought sand with his coin. But one coin bought only a bit of sand. Even when he had spread it as much as he could, the sand covered only half of the floor. "What did you buy?" the eldest son angrily asked the youngest son. "You don't have any straw." "Yes, what did you buy?" the second son asked angrily. "You don't have any sand." "I bought this," said the youngest son. "A candle!" cried his brothers. "What good is a candle?" "Watch", said the youngest son. He lit the candle, and all at once the room was filled from wall to wall, from ceiling to floor. It was filled with light! "Although you are the youngest, you are indeed the cleverest of my sons," the old merchant said. And that is how, the old merchant left his fortune to his youngest son, the one who could fill a room with light.
Question: Who would get father's fortune?

SOLUTION: the cleverest son.

PROBLEM: Context: Transcription-coupled repair (TCR) is the major pathway involved in the removal of UV-induced photolesions from the transcribed strand of active genes. Two Cockayne syndrome (CS) complementation group proteins, CSA and CSB, are important for TCR repair. The molecular mechanisms by which CS proteins regulate TCR remain elusive. Here, we report the characterization of KIAA1530, an evolutionarily conserved protein that participates in this pathway through its interaction with CSA and the TFIIH complex. We found that UV irradiation led to the recruitment of KIAA1530 onto chromatin in a CSA-dependent manner. Cells lacking KIAA1530 were highly sensitive to UV irradiation and displayed deficiency in TCR. In addition, KIAA1530 depletion abrogated stability of the CSB protein following UV irradiation. More excitingly, we found that a unique CSA mutant (W361C), which was previously identified in a patient with UV(s)S syndrome, showed defective KIAA1530 binding and resulted in a failure of recruiting KIAA1530 and stabilizing CSB after UV treatment. Together, our data not only reveal that KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome.
Question: Which gene strand is targeted by transcription-coupled repair (TCR)?

SOLUTION:
the transcribed strand