Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy.

Ex Output:
Which gene is responsible for the development of the Mowat-Wilson syndrome?

Ex Input:
In the mid 1900s, people were startled to see the Cuyahoga River in Cleveland, Ohio, burst into flames! The river was so polluted with oil and other industrial wastes that it was flammable. Nothing could live in it. You can see the Cuyahoga River in Figure 21.16 Disasters such as rivers burning led to new U.S. laws to protect the water. For example, the Environmental Protection Agency (EPA) was established, and the Clean Water Act was passed. Now, water is routinely tested. Pollution is tracked to its source, and polluters are forced to fix the problem and clean up the pollution. They are also fined. These consequences have led industries, agriculture, and communities to pollute the water much less than before. Most water pollution comes from industry, agriculture, and municipal sources. Homes are part of the municipal source and the individuals and families that live in them can pollute the water supply. What can you do to reduce water pollution? Read the tips below. Properly dispose of motor oil and household chemicals. Never pour them down the drain. Also, dont let them spill on the ground. This keeps them out of storm sewers and bodies of water. Use fewer lawn and garden chemicals. Use natural products instead. For example, use compost instead of fertilizer. Or grow plants that can thrive on their own without any extra help. Repair engine oil leaks right away. A steady drip of oil from an engine can quickly add up to gallons. When the oil washes off driveways and streets it can end up in storm drains and pollute the water supply. Dont let pet litter or pet wastes get into the water supply (see Figure 21.17). The nitrogen they contain can cause overgrowth of algae. The wastes may also contain bacteria and other causes of disease. Water treatment is a series of processes that remove unwanted substances from water. The goal of water treatment is to make the water safe to return to the natural environment or to the human water supply. Treating water for other purposes may not include all the same steps. Thats because water used in agriculture or industry may not have to be as clean as drinking water. You can see how water for drinking is treated in Figure 21.18. Treating drinking water requires at least four processes: 1. Chemicals are added to untreated water. They cause solids in the water to clump together. This is called coagulation. 2. The water is moved to tanks. The clumped solids sink to the bottom of the water. This is called sedimentation. 3. The water is passed through filters that remove smaller particles from the water. This is called filtration. 4. Chlorine is added to the water to kill bacteria and other microbes. This is called disinfection. Finally, the water is pure enough to drink. Conserving water means using less of it. Of course, this mostly applies to people in the wealthy nations that have the most water and also waste the most. Irrigation is the single biggest use of water. Overhead irrigation wastes a lot of water. Drip irrigation wastes a lot less. Figure 21.19 shows a drip irrigation system. Water pipes run over the surface of the ground. Tiny holes in the pipes are placed close to each plant. Water slowly drips out of the holes and soaks into the soil around the plants. Very little of the water evaporates or runs off the ground. Some communities save water with rationing. Much rationing takes place only during times of drought. During rationing, water may not be used for certain things. For example, communities may ban lawn watering and car washing. People may be fined if they use water in these ways. You can do your part. Follow any bans where you live. Its easy to save water at home. If you save even a few gallons a day you can make a big difference over the long run. The best place to start saving water is in the bathroom. Toilet flushing is the single biggest use of water in the home. Showers and baths are the next biggest use. Follow the tips below to save water at home. Install

Ex Output:
process in water treatment in which small particles are separated from water

Ex Input:
When did you last visit a shopping mall? In many places, the answer would be "last weekend." Some people go even more often. Why? For one thing, malls offer goods and services that people need all in one place: food, clothing, things for their houses, entertainment, even medical services. So, are malls one of the highlights of modern civilization? Environmental activists would say No! They would go even further and say that consumer behavior is causing a huge environmental disaster. cause consumers of ignorance of the side effect of their shopping--urban sprawl . Social scientists agree that patterns of development have changed the landscape a great deal in the last half century. Before 1950, most people lived in towns or cities and either walked to work or took public transportation. Only very wealthy people had automobiles. Farmers lived in rural areas or isolated villages and came into town only when they needed things they couldn't produce themselves. If you gazed at the landscape you would see towns surrounded by countryside. Then a massive change occurred. Automobiles became affordable and people were quick to adopt them. Now ambitious workers could live in the suburbs, the areas just outside cities, which started to grow rapidly. As long as there was lots of cheap land in the suburbs, no one paid much attention to the usage of that land. Malls, fast food restaurants, cinemas, and car dealerships spread out in large, flat buildings. These one-storey buildings and their parking lot took up a great deal space. Well- meaning farmers thought they were better off selling their land than growing crops. In ignorance, no one realized that once the land was built up in urban sprawl, the good farming land would be ruined forever. There was no way to preserve it. Only in recent years have people come to mourn the old way of life as they have developed insight into the problems. Now people realize that urban sprawl has come with serious environmental problems. The negative aspects of sprawl include air and water pollution, loss of agricultural land, traffic jams, and the death of businesses in the old town centers. Many scholars think the time has come to analyze the problems better so we can develop appropriate policies to control further sprawl. Some think the best way to do is to educate citizens about their priceless environment.

Ex Output:
What is the scholars' attitude toward urban sprawl?