Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.

Answer: What is the characteristic domain of histone methyltransferases?

Question: The SP790 study (ClinicalTrials.gov, NCT00136045) showed benefits of rotigotine over placebo in improving symptom severity of restless legs syndrome (RLS), also known as Willis-Ekbom disease, on the International Restless Legs Syndrome Study Group rating scale (IRLS), Clinical Global Impression item 1 (CGI-1), RLS 6-item questionnaire (RLS-6), and the RLS-quality of life questionnaire (RLS-QoL) in patients with moderate to severe idiopathic RLS. To provide clinical context for the IRLS and to guide the choice of assessment scales for RLS studies, our post hoc analysis of SP790 data evaluated associations between the IRLS and the CGI-1, IRLS and RLS-6, and the IRLS and RLS-QoL. Scale associations were analyzed at baseline and at the end of maintenance (EoM) using data from the safety set (rotigotine and placebo groups combined [n=458]). Changes from baseline to EoM in IRLS score vs comparator scale scores also were analyzed. There was a trend towards increasing IRLS severity category with increasing CGI-1, RLS-6, and RLS-QoL score. Pearson product moment correlation coefficients showed correlations between IRLS and comparator scale scores at baseline and EoM as well as correlations for change from baseline to EoM. Correlations between the IRLS and comparator scales were substantial. These data indicate that the IRLS is clinically meaningful. The IRLS and CGI-1 are generally sufficient to evaluate the overall severity and impact of RLS symptoms in clinical trials.

Answer: Willis-Ekbom disease is also known as?

Question: Meanwhile, in 1274, the former Dali Kingdom was officially reorganized as the Province of Yunnan, with Sayyid Ajjal Shams al-Din Omar as governor. In May 1275, the governor sent a report to the emperor stating that the embassy had not returned; that the Burmese evidently had no intention of submitting; and that war was the only way forward. But the emperor rejected an outright invasion. Just coming off a disastrous Japanese campaign, the emperor was unwilling to commit the central government troops to what he considered a low priority affair. He was now focused on delivering the final blow against the Song; the emperor ordered the Yunnan provincial army to secure the borderlands in order to block the escape path of the Song refugees. He also sanctioned a limited border war if Pagan contested the takeover. As planned, the Yunnan army proceeded to consolidate the borderlands in 1275-76. Elsewhere, the main Mongol armies had captured most of the Song territory by 1276. By 1277, at least one Burmese vassal state named "Gold Teeth" had submitted to the Mongols. Like in 1272, the Burmese government responded by sending an army to reclaim the rebellious state; but unlike in 1272, the Mongols had posted a sizable garrison there. Though it was ultimately under Mongol command, many of the officers and most of the soldiers of the garrison were Turkic-speaking peoples or people from the further west: Turks from Samarkand, Bukhara, Merv and Nishapur, but also captive soldiers from the Persian Khwarazmid empire, the Kipchaks, and even Bulgars from the lower Volga.

Answer:
Which happened first, the capture of Sond territory, or "Gold Teeth" submitting to the Mongols?