Q: U.S. Route 42 (US 42) is an east -- west United States highway that runs southwest-northeast for 355 miles (571 km) from Louisville, Kentucky to Cleveland, Ohio. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, Reading Road in Cincinnati, Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville. Traveling east, the highway ends in downtown Cleveland, Ohio; and traveling west it ends in Louisville.

Answer this question: where does us route 42 start and end?
A: from Louisville , Kentucky to Cleveland , Ohio
Explain how we arrive at this answer:
Explanation: The relevant information is: U.S. Route 42 (US 42) is an east -- west United States highway that runs southwest-northeast for 355 miles (571 km) from Louisville, Kentucky to Cleveland, Ohio.