Given the task definition, example input & output, solve the new input case.
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
Example: Paragraph: The severe acute respiratory syndrome (SARS) epidemic originating from China in 2002 was caused by a previously uncharacterized coronavirus that could be identified by specific RT-PCR amplification. Efforts to control future SARS outbreaks depend on the accurate and early identification of SARS-CoV infected patients. A real-time fluorogenic RT-PCR assay based on the 3 -noncoding region (3 -NCR) of SARS-CoV genome was developed as a quantitative SARS diagnostic tool. The ideal amplification efficiency of a sensitive SARS-CoV RT-PCR assay should yield an E value (PCR product concentration increase per amplification cycle) equal to 2.0. It was demonstrated that the 3 -NCR SARS-CoV based RT-PCR reactions could be formulated to reach excellent E values of 1.81, or 91% amplification efficacy. The SARS-CoV cDNA preparations derived from viral RNA extract and the cloned recombinant plasmid both exhibit the identical amplification characteristics, i.e. amplification efficacy using the same PCR formulation developed in this study. The viral genomic copy (or genomic equivalences, GE) per infectious unit (GE/pfu) of SARS-CoV used in this study was also established to be approximate 1200-1600:1. The assay's detection sensitivity could reach 0.005 pfu or 6-8 GE per assay. It was preliminarily demonstrated that the assay could efficiently detect SARS-CoV from clinical specimens of SARS probable and suspected patients identified in Taiwan. The 3 -NCR based SARS-CoV assay demonstrated 100% diagnostic specificity testing samples of patients with acute respiratory disease from a non-SARS epidemic region.
Title: Development and evaluation of an efficient 3 -noncoding region-based SARS coronavirus (SARS-CoV) RT-PCR assay for detection of SARS-CoV
Output: True
The answer is true because the title of the paragraph is correct where it described the development of 3 -noncoding region of SARS-CoV genome and assay efficiently detecting SARS-CoV from clinical specimens.

New input case for you: Paragraph: The ongoing COVID-19 pandemic has reached more than 200 countries and territories worldwide. Given the large requirement of SARS-CoV-2 diagnosis and considering that RNA extraction kits are in short supply, we investigated whether two commercial RT-qPCR kits were compatible with direct SARS-CoV-2 detection from nasopharyngeal swab samples. We show that one of the tested kits is fully compatible with direct SARS-CoV-2 detection suggesting that omission of an RNA extraction step should be considered in SARS-CoV-2 diagnosis. Two coronaviruses, SARS-CoV (severe acute respiratory syndrome coronavirus) and MERS-CoV (Middle East respiratory syndrome coronavirus) caused large-scale severe respiratory syndromes in humans in 2002 and 2013, respectively 1, 2 . A recent outbreak of pneumonia in Wuhan, China declared in December 12 th 2019 led to the isolation and identification of a new human coronavirus, 2019-nCoV (SARS-CoV-2), as the responsible agent of this new acute respiratory syndrome 3 . Since, SARS-CoV-2 and the Coronavirus disease 19 (COVID-19) have spread to more than 200 countries and territories worldwide affecting more than 600,000 people (laboratory-confirmed cases) from which around 28,000 have died by COVID-19 4 . As such, the WHO declared COVID-19 outbreak as a pandemic on March 11 th 2020 5 . Given the rapid spread of the SARS-CoV-2 virus and that an important fraction of the infected individuals remains asymptomatic but still spread the virus 6 , rapid and extensive diagnosis together with the isolation of infected individuals remains as one of the most powerful ways to avoid the spread of new COVID-19 cases. There are several RT-qPCR protocols from different countries that are currently approved by the WHO in order to detect SARS-CoV-2 7 . However, one of the limiting steps of such protocols is RNA extraction from clinical samples, which is currently performed by the use of a limited quantity of approved RNA extraction kits. Since the current demand for those kits largely exceeds their offer, it is necessary to develop alternative strategies allowing a rapid detection of the virus. This becomes more important in middle-and low-income countries, which will not have massive access to kit-based diagnosis 8, 9 . In this sense, it was recently reported that the detection of SARS-CoV-2 by RT-qPCR from a mixed sample could be achieved with non-approved kits but also in the absence of an RNA extraction process 10 . Here, we have extended these preliminary observations by using an RNA extraction-free SARS-CoV-2 detection protocol from nasopharyngeal swab samples from two COVID-19 diagnosed individuals using two commercially available and broadly used RT-qPCR kits. Our data indicate that RNA extraction can be omitted from the protocol at least with one of the tested kits allowing the rapid and reliable detection of SARS-CoV-2 directly from nasopharyngeal swabs samples.
Title: SARS-CoV-2 detection from nasopharyngeal swab samples without RNA extraction
Output:
False