This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

[Q]: The double indirect method can be used when it is important to see the work during the creation process as it will appear when completed. The tesserae are placed face-up on a medium (often adhesive-backed paper, sticky plastic or soft lime or putty) as it will appear when installed. When the mosaic is complete, a similar medium is placed atop it. The piece is then turned over, the original underlying material is carefully removed, and the piece is installed as in the indirect method described above. In comparison to the indirect method, this is a complex system to use and requires great skill on the part of the operator, to avoid damaging the work. Its greatest advantage lies in the possibility of the operator directly controlling the final result of the work, which is important e.g. when the human figure is involved. This method was created in 1989 by Maurizio Placuzzi and registered for industrial use (patent n. 0000222556) under the name of his company, Sicis International Srl, now Sicis The Art Mosaic Factory Srl.
[A]: When is the double indirect method of mosaic useful?

[Q]: Near the intersection of Craycroft and Ft. Lowell Roads are the remnants of the Historic Fort Lowell. This area has become one of Tucson's iconic neighborhoods. In 1891, the Fort was abandoned and much of the interior was stripped of their useful components and it quickly fell into ruin. In 1900, three of the officer buildings were purchased for use as a sanitarium. The sanitarium was then sold to Harvey Adkins in 1928. The Bolsius family Pete, Nan and Charles Bolsius purchased and renovated surviving adobe buildings of the Fort transforming them into spectacular artistic southwestern architectural examples. Their woodwork, plaster treatment and sense of proportion drew on their Dutch heritage and New Mexican experience. Other artists and academics throughout the middle of the 20th century, including: Win Ellis, Jack Maul, Madame Cheruy, Giorgio Belloli, Charels Bode, Veronica Hughart, Edward and Rosamond Spicer, Hazel Larson Archer and Ruth Brown, renovated adobes, built homes and lived in the area. The artist colony attracted writers and poets including beat generation Alan Harrington and Jack Kerouac whose visit is documented in his iconic book On the Road. This rural pocket in the middle of the city is listed on the National Register of Historic Places. Each year in February the neighborhood celebrates its history in the City Landmark it owns and restored the San Pedro Chapel.
[A]: Who bought The sanitarium in 1928?

[Q]: Since genomes are very complex, one research strategy is to reduce the number of genes in a genome to the bare minimum and still have the organism in question survive. There is experimental work being done on minimal genomes for single cell organisms as well as minimal genomes for multi-cellular organisms (see Developmental biology). The work is both in vivo and in silico.
[A]:
What is a name for the reduced complement of genetic material necessary for an organism to live?