Given the task definition and input, reply with output. In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: How is it possible that during the replication of the bacterial DNA the guide (or forward) and delayed strands are synthesized in a coordinated way?
Options: <1> The guide strand is synthesized in the 5'-3'direction and the delayed one in the 3'-5'direction. <2> The holoenzyme DNA Polymerase III contains two copies of the catalytic core of the enzyme. <3> Proteins bound to the delayed strand control the synthesis speed of the guide strand. <4> Specific enzymes control the opening of the replication fork. <5> The helicase controls the speed of synthesis in both strands.
2