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In the early and mid-2000s, the Bush administration called numerous times for investigation into the safety and soundness of the GSEs and their swelling portfolio of subprime mortgages. On September 10, 2003, the House Financial Services Committee held a hearing at the urging of the administration to assess safety and soundness issues and to review a recent report by the Office of Federal Housing Enterprise Oversight (OFHEO) that had uncovered accounting discrepancies within the two entities. The hearings never resulted in new legislation or formal investigation of Fannie Mae and Freddie Mac, as many of the committee members refused to accept the report and instead rebuked OFHEO for their attempt at regulation. Some believe this was an early warning to the systemic risk that the growing market in subprime mortgages posed to the U.S. financial system that went unheeded.

What was the result of the House Financial Services Committee on September 10, 2003 regarding Fannie Mae and Freddie Mac?
Answer: The hearings never resulted in new legislation or formal investigation
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Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Those that target protein synthesis (macrolides, lincosamides and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Further categorization is based on their target specificity. "Narrow-spectrum" antibacterial antibiotics target specific types of bacteria, such as Gram-negative or Gram-positive bacteria, whereas broad-spectrum antibiotics affect a wide range of bacteria. Following a 40-year hiatus in discovering new classes of antibacterial compounds, four new classes of antibacterial antibiotics have been brought into clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).

What is another name used for bacterial cell wall?
Answer: penicillins and cephalosporins
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Rare books are found in several Yale collections. The Beinecke Rare Book Library has a large collection of rare books and manuscripts. The Harvey Cushing/John Hay Whitney Medical Library includes important historical medical texts, including an impressive collection of rare books, as well as historical medical instruments. The Lewis Walpole Library contains the largest collection of 18thcentury British literary works. The Elizabethan Club, technically a private organization, makes its Elizabethan folios and first editions available to qualified researchers through Yale.

Where can qualified researchers obtain Elizabethan folios?
Answer:
The Elizabethan Club