Problem: Please answer a question about the following article about Gene:
Although the number of base-pairs of DNA in the human genome has been known since the 1960s, the estimated number of genes has changed over time as definitions of genes, and methods of detecting them have been refined. Initial theoretical predictions of the number of human genes were as high as 2,000,000. Early experimental measures indicated there to be 50,000100,000 transcribed genes (expressed sequence tags). Subsequently, the sequencing in the Human Genome Project indicated that many of these transcripts were alternative variants of the same genes, and the total number of protein-coding genes was revised down to ~20,000 with 13 genes encoded on the mitochondrial genome. Of the human genome, only 12% consists of protein-coding genes, with the remainder being 'noncoding' DNA such as introns, retrotransposons, and noncoding RNAs.
What sort of variants did the Human Genome Project indicate that many of the measured transcripts were?
A: alternative variants
Problem: Please answer a question about the following article about Queen Victoria:
At the time of her accession, the government was led by the Whig prime minister Lord Melbourne, who at once became a powerful influence on the politically inexperienced Queen, who relied on him for advice. Charles Greville supposed that the widowed and childless Melbourne was "passionately fond of her as he might be of his daughter if he had one", and Victoria probably saw him as a father figure. Her coronation took place on 28 June 1838 at Westminster Abbey. Over 400,000 visitors came to London for the celebrations. She became the first sovereign to take up residence at Buckingham Palace and inherited the revenues of the duchies of Lancaster and Cornwall as well as being granted a civil list allowance of 385,000 per year. Financially prudent, she paid off her father's debts.
When was Queen Victorias coronation held?
A: 28 June 1838
Problem: Please answer a question about the following article about Chihuahua (state):
On March 26, 1913, Venustiano Carranza issued the Plan de Guadalupe, which refused to recognize Huerta as president and called for war between the two factions. Soon after the assassination of President Madero, Carranza returned to Mexico to fight Huerta, but with only a handful of comrades. However, by 1913 his forces had swelled into an army of thousands, called the Division del Norte (Northern Division). Villa and his army, along with Emiliano Zapata and Alvaro Obregon, united with Carranza to fight against Huerta. In March 1914 Carranza traveled to Ciudad Juarez, which served as rebellion's capital for the remainder of the struggle with Huerta. In April 1914 U.S. opposition to Huerta had reached its peak, blockading the regime's ability to resupply from abroad. Carranza trying to keep his nationalistic credentials threatened war with the United States. In his spontaneous response to U.S. President Woodrow Wilson Carranza asked "that the president withdraw American troops from Mexico."
Who issued the Plan de Guadalupe?
A: Venustiano Carranza
Problem: Please answer a question about the following article about Pain:
In 1994, responding to the need for a more useful system for describing chronic pain, the International Association for the Study of Pain (IASP) classified pain according to specific characteristics: (1) region of the body involved (e.g. abdomen, lower limbs), (2) system whose dysfunction may be causing the pain (e.g., nervous, gastrointestinal), (3) duration and pattern of occurrence, (4) intensity and time since onset, and (5) etiology. However, this system has been criticized by Clifford J. Woolf and others as inadequate for guiding research and treatment. Woolf suggests three classes of pain : (1) nociceptive pain, (2) inflammatory pain which is associated with tissue damage and the infiltration of immune cells, and (3) pathological pain which is a disease state caused by damage to the nervous system or by its abnormal function (e.g. fibromyalgia, irritable bowel syndrome, tension type headache, etc.).
Who has criticized the IASP's system?
A:
Clifford J. Woolf and others