Coming off their home win over the Rams, the Bengals flew to Bill Walsh Field at Monster Park for a Saturday night interconference duel with the San Francisco 49ers. After a scoreless first quarter, Cincinnati trailed early in the second quarter as 49ers QB Shaun Hill got a 3-yard TD run. Afterwards, the Bengals would take the lead as kicker Shayne Graham managed to get a 24-yard field goal, while QB Carson Palmer completed a 52-yard TD pass to WR Chris Henry. San Francisco would end the half with Hill completing a 17-yard TD pass to TE Vernon Davis. In the third quarter, the 49ers increased their lead with kicker Joe Nedney getting a 29-yard and a 38-yard field goal. In the fourth quarter, Cincinnati tried to respond as Graham kicked a 35-yard field goal. However, the 49ers' defense held on for the win. With the loss, the Bengals fell to 5-9, securing Head Coach Marvin Lewis' first losing season with Cincinnati.

Who had more yards, Nedney or Graham?
A: Nedney

The Titans began their season on the road against their division rival, the Jacksonville Jaguars. In the first quarter, Tennessee struck first with kicker Rob Bironas getting a 20-yard field goal. Afterwards, the Jaguars took the lead with QB David Garrard completing a 47-yard TD pass to WR John Broussard. In the second quarter, Jacksonville increased its lead with kicker Josh Scobee getting a 22-yard field goal. Afterwards, the Titans would draw closer with Bironas kicking a 31-yard field goal. In the third quarter, Tennessee took the lead for good with QB Vince Young running into the end zone from 2 yards out for the final score of the game.

Which team scored last in the game?
A: Titans

The Bears traveled to the newly opened University of Phoenix Stadium to play the Arizona Cardinals, their former cross-town rivals. While many expected the game a lop-sided affair in favor of the 5-0 Bears, the Cardinals led the Bears before stumbling in the game's last quarter. The game marked the Bears' first Monday Night Football appearance since the 2003 NFL season, and second overall prime-time appearance of the season. The game started on an auspicious note for the Cardinals, as Rex Grossman faced a quick three and out after failing to connect to Bernard Berrian on a deep pass. The Cardinals responded offensively when rookie quarterback Matt Leinart threw two touchdowns in the first quarter. As Neil Rackers helped bolster the Cardinals lead with a set of field goals, Grossman continued to struggle and committed four turnovers in the first half alone. By half time, the Cardinals were leading the Bears by a score of 20-0, which was the largest deficit they had faced all season at that point. The Bears finally got on the score board in the third quarter when Robbie Gould kicked a 23-yard field goal. However, Rackers responded again to boost the Cardinals lead back to twenty points. By the game's third quarter, many had assumed the Cardinals had grasped their second win of the season, and the undefeated Bears would be forced to face defeat. However, in the dying minutes of the third quarter, the Bears' defense made a series of staunch defensive plays that allowed them to rally back. First, rookie defensive end Mark Anderson sacked Leinart, causing him to fumble. The loose ball was picked up by Mike Brown, who returned it for a 3-yard touchdown. Later, Brian Urlacher stripped the ball from running back Edgerrin James, and Charles Tillman recovered the football and returned it for another touchdown. The Bears, now only trailing by six points, took the lead when rookie punt returner Devin Hester returned a punt for an 83-yard touchdown. The Cardinals had one final attempt to win the game, but Rackers missed a 40-yard field goal attempt, allowing the Bears to kneel the clock out. After the game's conclusion, Dennis Green, who was the Cardinal's coach at the time, threw his infamous "They are who we thought they were!" postgame conference. The rant became so popular, that it was featured in a Coors Light commercial the next season.

Which quarterback had more turnovers, Grossman or Leinart?
A:
Grossman