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Mutations or deletions of clock gene in mice have demonstrated the importance of body clocks to ensure the proper timing of cellular/metabolic events; clock-mutant mice are hyperphagic and obese, and have altered glucose metabolism. In mice, deletion of the Rev-ErbA alpha clock gene facilitates diet-induced obesity and changes the balance between glucose and lipid utilization predisposing to diabetes. However, it is not clear whether there is a strong association between clock gene polymorphisms in humans and the susceptibility to develop the metabolic syndrome.
How certain is it that these circadian clock effects are the same in humans?
A: not clear

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Magadha (Sanskrit: ) formed one of the sixteen Maha-Janapadas (Sanskrit: "Great Countries") or kingdoms in ancient India. The core of the kingdom was the area of Bihar south of the Ganges; its first capital was Rajagriha (modern Rajgir) then Pataliputra (modern Patna). Magadha expanded to include most of Bihar and Bengal with the conquest of Licchavi and Anga respectively, followed by much of eastern Uttar Pradesh and Orissa. The ancient kingdom of Magadha is heavily mentioned in Jain and Buddhist texts. It is also mentioned in the Ramayana, Mahabharata, Puranas. A state of Magadha, possibly a tribal kingdom, is recorded in Vedic texts much earlier in time than 600 BC. Magadha Empire had great rulers like Bimbisara and Ajatshatru.
How does the Sanskrit translate Maha-Janapadas?
A: Great Countries

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By the mid 18th century, the movement broadened to incorporate a greater range of Classical influences, including those from Ancient Greece. The shift to neoclassical architecture is conventionally dated to the 1750s. It first gained influence in England and France; in England, Sir William Hamilton's excavations at Pompeii and other sites, the influence of the Grand Tour and the work of William Chambers and Robert Adam, was pivotal in this regard. In France, the movement was propelled by a generation of French art students trained in Rome, and was influenced by the writings of Johann Joachim Winckelmann. The style was also adopted by progressive circles in other countries such as Sweden and Russia.
In what city did a generation of French art students study that propelled neoclassical architecture and incorporation broader styles?
A: Rome

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Double fertilization refers to a process in which two sperm cells fertilize cells in the ovary. This process begins when a pollen grain adheres to the stigma of the pistil (female reproductive structure), germinates, and grows a long pollen tube. While this pollen tube is growing, a haploid generative cell travels down the tube behind the tube nucleus. The generative cell divides by mitosis to produce two haploid (n) sperm cells. As the pollen tube grows, it makes its way from the stigma, down the style and into the ovary. Here the pollen tube reaches the micropyle of the ovule and digests its way into one of the synergids, releasing its contents (which include the sperm cells). The synergid that the cells were released into degenerates and one sperm makes its way to fertilize the egg cell, producing a diploid (2n) zygote. The second sperm cell fuses with both central cell nuclei, producing a triploid (3n) cell. As the zygote develops into an embryo, the triploid cell develops into the endosperm, which serves as the embryo's food supply. The ovary now will develop into fruit and the ovule will develop into seed.
What begins the process of synergid?
A:
unanswerable