instruction:
You are given a background paragraph that describes one or more causal or qualitative relationships such as a relationship in economics or a scientific law and a story that makes use of the concepts or the relationship described in the provided paragraph. You need to come up with a question about the story that requires an understanding of the relationship described in the background paragraph. The generated question should not be answerable without both the background and story. Write a question about the story that requires a relationship in the background paragraph to answer. Check whether your question requires both the background paragraph and the story to answer. If your question can be answered by only one of these, try to rewrite your question so that it requires both. Note that "flipping" a word in the question can give rise to a new question where the answer will be different from the original question. Often, "flipping" a word gives rise to flipping the direction of the relationship, for example, from "increase" to "decrease."
question:
Background Paragraph: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem.
Story: Two university students studied different types of drugs for their exams. Kate studied statins, while Carol studied anti-depressants.
answer:
Which student learned less about an inhibitor of HMG-CoA reductase?

question:
Background Paragraph: Another major cause of extinction is global warming , which is also known as global climate change. During the past century, the Earth's average temperature has risen by almost 1C (about 1.3F). You may not think that is significant, but to organisms that live in the wild and are constantly adapting to their environments, any climate change can be hazardous. Recall that burning fossil fuels releases gasses into the atmosphere that warm the Earth. Our increased use of fossil fuels, such as coal and oil, is changing the Earth's climate. Any long-term change in the climate can destroy the habitat of a species. Even a brief change in climate may be too stressful for an organism to survive. For example, if the seas increase in temperature, even briefly, it may be too warm for certain types of fish to reproduce.
Story: Two students studied for the biology exam. Ken studied about global warming, while Hank studied about Earth's oceans.
answer:
Which student learned less about the increasing use of oil?

question:
Background Paragraph: Fish mortality is a parameter used in fisheries population dynamics to account for the loss of fish in a fish stock through death. The mortality can be divided into two types:

Natural mortality: the removal of fish from the stock due to causes not associated with fishing. Such causes can include disease, competition, cannibalism, old age, predation, pollution or any other natural factor that causes the death of fish. In fisheries models natural mortality is denoted by (M).[1]
Fishing mortality: the removal of fish from the stock due to fishing activities using any fishing gear.[1] It is denoted by (F) in fisheries models.
Story: The fisherman had 2 choices: he could go to Silver Lake situated at a higher altitude and fish there; or he could go to Red lake, a few miles further down the road. Both lakes were natural, but Red Lake had a few pollution problems last year, and the oxygen levels in the water decreased, leading to many fish dying. Silver lake was still pristine, untouched by human activities such as pollution.
answer:
Which lake had a higher fishing mortality last year?