Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder resulting in the growth of a variety of tumours, and is inherited in an autosomal dominant pattern. Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that commonly harbour oncogenic mutations in KIT or PDGFRA and are thought to arise from the interstitial cells of Cajal (ICC; the pacemaker cells of the gut). To characterise two patients with NF1 and GISTs. Two patients were genotyped for germline mutations in NF1. GISTs from both patients were genotyped for somatic mutations in KIT and PDGFRA. Loss of heterozygosity (LOH) of NF1 in one GIST was assessed by genotyping seven microsatellite markers spanning 2.39 Mb of the NF1 locus in the tumour and in genomic DNA. The known germline mutation in NF1 was confirmed in GIST DNA by sequencing. The copy number of the mutated NF1 allele was determined by multiplex ligand-dependent probe amplification. GISTs from both patients were of wild type for mutations in KIT and PDGFRA. In the GIST with adequate DNA, all seven markers were informative and showed LOH at the NF1 locus; sequencing of NF1 from that GIST showed no wild-type sequence, suggesting that it was lost in the tumour. Multiplex ligand-dependent probe amplification analysis showed that two copies of all NF1 exons were present. This is the first evidence of mitotic recombination resulting in a reduction to homozygosity of a germline NF1 mutation in an NF1-associated GIST. We hypothesise that the LOH of NF1 and lack of KIT and PDGFRA mutations are evidence of an alternative pathogenesis in NF1-associated GISTs.

Output: Which is the gene mutated in type 1 neurofibromatosis?

Input: Consider Input: With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.

Output: What does mTOR stands for?

Input: Consider Input: In an endothermic reaction, it takes more energy to break bonds in the reactants than is released when new bonds form in the products. The word "endothermic" literally means "taking in heat." A constant input of energy, often in the form of heat, is needed in an endothermic reaction. Not enough energy is released when products form to break more bonds in the reactants. Additional energy is needed to keep the reaction going. The general equation for an endothermic reaction is: Reactants + Energy ! Products In many endothermic reactions, heat is absorbed from the surroundings. As a result, the temperature drops. The drop in temperature may be great enough to cause liquid products to freeze. Thats what happens in the endothermic reaction at this URL: One of the most important endothermic reactions is photosynthesis. In this reaction, plants synthesize glucose (C6 H12 O6 ) from carbon dioxide (CO2 ) and water (H2 O). They also release oxygen (O2 ). The energy for photo- synthesis comes from light (see Figure 8.12). Without light energy, photosynthesis cannot occur. The chemical equation for photosynthesis is: 6CO2 + 6H2 O ! C6 H12 O6 + 6O2 In an exothermic reaction, it takes less energy to break bonds in the reactants than is released when new bonds form in the products. The word "exothermic" literally means "turning out heat." Energy, often in the form of heat, is released as an exothermic reaction occurs. The general equation for an exothermic reaction is: Reactants ! Products + Energy If the energy is released as heat, an exothermic reaction results in a rise in temperature. Thats what happens in the exothermic reaction at the URL below. Combustion reactions are examples of exothermic reactions. When substances burn, they usually give off energy as heat and light. Look at the big bonfire in Figure 8.13. You can see the light energy it is giving off. If you were standing near the fire, you would also feel its heat. Whether a reaction absorbs energy or releases energy, there is no overall change in the amount of energy. Energy cannot be created or destroyed. This is the law of conservation of energy. Energy can change form for example, from electricity to light but the same amount of energy always remains. If energy cannot be destroyed, what happens to the energy that is absorbed in an endothermic reaction? The energy is stored in the chemical bonds of the products. This form of energy is called chemical energy. In an endothermic reaction, the products have more stored chemical energy than the reactants. In an exothermic reaction, the opposite is true. The products have less stored chemical energy than the reactants. The excess energy in the reactants is released to the surroundings when the reaction occurs. The graphs in Figure 8.14 show the chemical energy of reactants and products in each type of reaction. All chemical reactions, even exothermic reactions, need a certain amount of energy to get started. This energy is called activation energy. For example, activation energy is needed to start a car. Turning the key causes a spark that activates the burning of gasoline in the engine. The combustion of gas wont occur without the spark of energy to begin the reaction. Why is activation energy needed? A reaction wont occur unless atoms or molecules of reactants come together. This happens only if the particles are moving, and movement takes energy. Often, reactants have to overcome forces that push them apart. This takes energy as well. Still more energy is needed to start breaking bonds in reactants. The graphs in Figure 8.15 show the changes in energy in endothermic and exothermic reactions. Both reactions need the same amount of activation energy in order to begin. You have probably used activation energy to start a chemical reaction. For example, if youve ever used a match to light a campfire, then you provided the activation energy needed to start a combustion reaction. Combustion is exothermic. Once a fire starts to burn, it releases enough energy to activate the next reaction, and the next, and so on. However, wood will not burst
Output: turning out heat