In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Ex Input:
Question: What specific procedure of the experimental strategy makes it the most appropriate to test hypotheses of causality? :
Options: <1> The representative sampling of the participants. <2> The manipulation of the independent variable with control of possible strange variables. <3> The realization of the study in real contexts with natural groups. <4> The identification of possible predictor variables through the retrospective analysis of the study phenomenon. <5> The application of statistical techniques for the analysis of data.

Ex Output:
2

Ex Input:
Question: A 45-year-old patient who went to the emergency room for general malaise, headache and progressive tiredness in recent weeks. On physical examination, a slight icteric dye of the skin and mucous membranes was detected and a 2-cm splenomegaly was felt under the costal margin. The analytical presents hemoglobin 8.6 g / dL, VCM 100 fL. The number of reticulocytes is high and anisopoikilocytosis is observed in the blood smear. In the biochemistry highlights LDH 1300 IU / L, bilirubin 2.2 mg / dL and undetectable haptoglobin. Which test is the most appropriate to guide the diagnosis of the patient?
Options: <1> Fecal occult blood test. <2> Test of Coombs. <3> Determination of iron, cobalamin and folic acid. <4> Abdominal ultrasound. <5> Bone marrow aspirate.

Ex Output:
2

Ex Input:
Question: In chronic bronchitis, it is characteristic:
Options: <1> Destruction of alveolar walls. <2> Difficulty in the inspiratory flow. <3> Decrease in the volume of inspiratory reserve. <4> Elevation of capillary hydrostatic pressure. <5> Inflammation and mucosal hypersecretion of the respiratory tract.

Ex Output:
5