You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a scientific passage and an answer, generate a question for the given answer.

Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Solution: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Why? The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.

New input: Passage: All chemical changes involve a transfer of energy. When zinc reacts with hydrochloric acid, the test tube becomes very warm as energy is released during the reaction. Some other reactions absorb energy. While energy changes are a potential sign of a chemical reaction, care must be taken to ensure that a chemical reaction is indeed taking place. Physical changes also involve a transfer of energy. Melting of a solid absorbs energy, while the condensation of a gas releases energy. The only way to be certain that a chemical reaction has taken place is to test the composition of the substances after the change has taken place to see if they are different from the starting substances. Answer: energy
Solution:
All chemical changes involve a transfer of what?