Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.
[A]: What is the characteristic domain of histone methyltransferases?

[Q]: The Jinfeng Gold Mine (Chinese: ) is an combined open pit and underground gold mining operation in the Guizhou province, China.
[A]: The product of Jinfeng Gold Mine is what?

[Q]: Fear and its companion pain are two of the most useful things that men and animals possess, if they are properly used. If fire did not hurt when it burnt, children would play with it until their hands were burnt away. Similarly, if pain existed but fear didn't, a child would burn himself or herself again and again, because fear would not warn himself or herself to keep away from the fire that had burnt himself or herself before. A really fearless soldier--and some do exist, is not a good soldier because he is soon killed; and a dead soldier is of no use to his army. Fear and pain are therefore two guards without which men and animals might soon die out. In our first sentence we suggested that fear should be properly used. If, for example, you never go out of your house because of the danger of being knocked down and killed in the street by a car, you are letting fear rule you too much. Even in your house you are not absolutely safe: an aeroplane may crash on your house, or ants may eat away some of the beams in your roof so that the latter falls on you, or you may get cancer! The important thing is not to let fear rule you, but instead to use fear as your servant and guide. Fear will warn you of dangers; then you have to decide what action to take. In many cases, you can take quick and successful action to avoid the danger. For example, you see a car coming straight towards you. Fear warns you, you jump out of the way, and all is well. In some cases, however, you decide that there is nothing that you can do to avoid the danger. For example, you can't prevent an aeroplane crashing onto your house. In this case, fear has given you its warning; you have examined it and decided on your course of action, so fear of this particular danger is no longer of any use to you, and you have to try to overcome it.
[A]:
What's the writer's suggestion when the danger can't be avoided?