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It's easier to see the dust and dirt when the monitor is off, and safer for you and your computer. Make sure that you let the screen cool down before you start if you're cleaning a plasma TV. If you try to clean the monitor while the pixels are firing you may end up damaging the screen. While the risk is small, there is the possibility of an electric shock if you clean the monitor while it's on. These can easily damage your screen, especially if it has a matte, anti-glare finish. If necessary, use distilled water. No tap water since it can leave mineral deposits on the screen. Make sure that your microfiber cloth is just barely damp. Consider buying a specifically formulated screen cleaning fluid. Read reviews and check your users manual to make sure which are safe for your particular monitor. For a mild homemade cleaner, mix water and white vinegar in equal proportions. Use this to dampen (not wet) your cleaning cloth. Always apply any liquid to the cloth, not directly to the screen, to prevent dripping (if even one drip reaches the bezel, it will immediately ruin your monitor). Don't use anything soapy that can leave a residue. These are convenient and specifically designed for monitors. Make sure they are gentle enough for anti-glare screens, if you have one. Read reviews online or ask a salesperson to find a good brand. This prevents any moisture that may have gotten into your monitor from causing damage, or electrical shock.
Turn off and unplug the monitor. Do not use ammonia, alcohol or acetone-based products. Consider using screen wipes. Make sure everything is dry before turning on your monitor.