In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: In the receptor-mediated endocytosis intervenes:
Options: <1> Only the clathrin. <2> Only the adaptin. <3> Adaptine and clathrin. <4> Chaperones <5> Only the proteins of the membrane.
3