Given the task definition and input, reply with output. In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: A 50-year-old patient with a pleural effusion with the following characteristics: straw appearance, pH 7.3, ratio of pleura / serum proteins 0.8, ratio of LDH pleura / serum 0.9, Gram and Ziehl negative, total lipids, cholesterol and normal triglycerides, cells mesothelial <5%, intense lymphocytosis without atypia, ADA 64 U / l. What diagnosis do you suggest?
Options: <1> Pleural empyema <2> Pleural effusion due to heart failure (transudate). <3> Pleural mesothelioma. <4> Tuberculous pleural effusion <5> Secondary effusion to pulmonary infarction.
4