Question: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.
Try to answer this question if possible: Who reported the stable average rate in 2007?
Answer: unanswerable
Question: Beyonce's first solo recording was a feature on Jay Z's "'03 Bonnie & Clyde" that was released in October 2002, peaking at number four on the U.S. Billboard Hot 100 chart. Her first solo album Dangerously in Love was released on June 24, 2003, after Michelle Williams and Kelly Rowland had released their solo efforts. The album sold 317,000 copies in its first week, debuted atop the Billboard 200, and has since sold 11 million copies worldwide. The album's lead single, "Crazy in Love", featuring Jay Z, became Beyonce's first number-one single as a solo artist in the US. The single "Baby Boy" also reached number one, and singles, "Me, Myself and I" and "Naughty Girl", both reached the top-five. The album earned Beyonce a then record-tying five awards at the 46th Annual Grammy Awards; Best Contemporary R&B Album, Best Female R&B Vocal Performance for "Dangerously in Love 2", Best R&B Song and Best Rap/Sung Collaboration for "Crazy in Love", and Best R&B Performance by a Duo or Group with Vocals for "The Closer I Get to You" with Luther Vandross.
Try to answer this question if possible: "The Closer I get to You" was recorded with which artist?
Answer: Luther Vandross
Question: The tradition of presenting the trophy immediately after the game did not start until the 1882 final; after the first final in 1872 the trophy was not presented to the winners, Wanderers, until a reception held four weeks later in the Pall Mall Restaurant in London. Under the original rules, the trophy was to be permanently presented to any club which won the competition three times, although when inaugural winners Wanderers achieved this feat by the 1876 final, the rules were changed by FA Secretary CW Alcock (who was also captain of Wanderers in their first victory).
Try to answer this question if possible: Who lost the 1876 final?
Answer: unanswerable
Question: Most definitions of sexual orientation include a psychological component, such as the direction of an individual's erotic desires, or a behavioral component, which focuses on the sex of the individual's sexual partner/s. Some people prefer simply to follow an individual's self-definition or identity. Scientific and professional understanding is that "the core attractions that form the basis for adult sexual orientation typically emerge between middle childhood and early adolescence". Sexual orientation differs from sexual identity in that it encompasses relationships with others, while sexual identity is a concept of self.
Try to answer this question if possible: What does a behaviorial component focus on when defining sexual orientation?
Answer:
focuses on the sex of the individual's sexual partner/s.