Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Delamanid (OPC-67683), a nitro-dihydro-imidazooxazole derivative, is a new antituberculosis medication that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis. In this randomized, placebo-controlled, multinational clinical trial, we assigned 481 patients (nearly all of whom were negative for the human immunodeficiency virus) with pulmonary multidrug-resistant tuberculosis to receive delamanid, at a dose of 100 mg twice daily (161 patients) or 200 mg twice daily (160 patients), or placebo (160 patients) for 2 months in combination with a background drug regimen developed according to World Health Organization guidelines. Sputum cultures were assessed weekly with the use of both liquid broth and solid medium; sputum-culture conversion was defined as a series of five or more consecutive cultures that were negative for growth of M. tuberculosis. The primary efficacy end point was the proportion of patients with sputum-culture conversion in liquid broth medium at 2 months. Among patients who received a background drug regimen plus 100 mg of delamanid twice daily, 45.4% had sputum-culture conversion in liquid broth at 2 months, as compared with 29.6% of patients who received a background drug regimen plus placebo (P=0.008). Likewise, as compared with the placebo group, the group that received the background drug regimen plus 200 mg of delamanid twice daily had a higher proportion of patients with sputum-culture conversion (41.9%, P=0.04). The findings were similar with assessment of sputum-culture conversion in solid medium. Most adverse events were mild to moderate in severity and were evenly distributed across groups. Although no clinical events due to QT prolongation on electrocardiography were observed, QT prolongation was reported significantly more frequently in the groups that received delamanid. Delamanid was associated with an increase in sputum-culture conversion at 2 months among patients with multidrug-resistant tuberculosis. This finding suggests that delamanid could enhance treatment options for multidrug-resistant tuberculosis. (Funded by Otsuka Pharmaceutical Development and Commercialization; ClinicalTrials.gov number, NCT00685360.).

Answer: Which disease can be treated with Delamanid?

Question: It is generally accepted that the mitochondria play central roles in energy production of most eukaryotes. In contrast, it has been thought that Plasmodium spp., the causative agent of malaria, rely mainly on cytosolic glycolysis but not mitochondrial oxidative phosphorylation for energy production during blood stages. However, Plasmodium spp. possesses all genes necessary for the tricarboxylic acid (TCA) cycle and most of the genes for electron transport chain (ETC) enzymes. Therefore, it remains elusive whether oxidative phosphorylation is essential for the parasite survival. To elucidate the role of TCA metabolism and ETC in malaria parasites, we deleted the gene for flavoprotein (Fp) subunit, Pbsdha, one of four components of complex II, a catalytic subunit for succinate dehydrogenase activity. The Pbsdha(-) parasite grew normally at blood stages in mouse. In contrast, ookinete formation of Pbsdha(-) parasites in the mosquito stage was severely impaired. Finally, Pbsdha(-) ookinetes failed in oocyst formation, leading to complete malaria transmission blockade. These results suggest that malaria parasite may switch the energy metabolism from glycolysis to oxidative phosphorylation to adapt to the insect vector where glucose is not readily available for ATP production.

Answer: Which is the causative agent of malaria?

Question: In 1957, when second-graders Bryce Loski and Julianna "Juli" Baker first meet, Juli knows it's love, but Bryce isn't so sure. Girl-phobic and easily embarrassed, young Bryce does everything he can to keep away as much as possible from Juli for the next six years, which isn't easy since they go to the same school and live across the street from each other. When they start the sixth grade, Bryce hopes that he can get rid of Juli so he asks the girl Juli hates the most, Shelly Stalls, out on a date. This plan of Bryce's works for a while up until his best friend, Garrett, takes an interest in Shelly and tells her the truth about Bryce asking her out. Juli finds out Bryce and Shelly break up; she goes back to her regular Bryce-obsessed self.From Juli's point of view, when she and Bryce first met, he returned her feelings but was just shy and embarrassed. When he "held her hand" she thought she would get her first kiss from him in the second grade. Juli knew that she was flipped from then on. After finding out that Bryce and Shelly broke up, she thought she could have her old Bryce back. She spent the whole year smelling his watermelon-scented hair and wondering if she'd ever get her kiss.In 1963, now in seventh grade, Bryce's grandfather Chet Duncan moves in with the family. Chet finds Juli different, special, and a rare kind of girl who's hard to come across. He continues to tell Bryce this with hope. There's a large, old sycamore tree that Juli loves which no one understands. One day, it's cut down by the owner in spite of Juli's protest and dismay. Her voice narrates her love for the tree that let her see the world in a much more enlightened way.Chet and Juli form a strong friendship over time while he helps her work on her messy lawn. Bryce begins to develop feelings for Juli just as Juli begins to question her feelings about Bryce. Her feelings completely disappear when she overhears him and Garrett talking about her mentally challenged uncle, and sees him throwing away the eggs she gave him. Juli tells Bryce she never wants to speak to him again when she and her family get invited to the Loski's house for a sit down dinner which ends up with Bryce's dad being considerably rude to her family. At the dinner she confronts him about what Bryce said about her uncle and tells him she doesn't want to speak to him again, not ever. During dinner, they sit opposite each other, she never talks or makes eye contact with him. After dinner she apologizes for the way she acted. Bryce is upset that she apologizes, because that means that she doesn't care enough to hold a grudge.She continues to have mixed feelings when the basket boy auction is just around the corner. She hears that Shelly is planning to bid on Bryce against another one of the school's "finest" girls. Bryce thinks that Juli is planning on bidding for him because he hears she walked in with a wad of cash (which she wasn't planning on having with her). Bryce begins to worry about what would happen if she does bid for him just when she bids all her cash on basket boy number eight, the boy before Bryce.Later, during the basket boy bidding lunch, Bryce and Shelly sit at a table across from Juli and basket boy number 8, Eddie Trulock. She's facing Bryce and he can't help but stare at Juli the whole time. He sees she's having a good time with her date and gets jealous. He grabs her to talk to her and attempts to kiss her in front of everyone. He chases her after she dodges his kiss. Juli gets on her bike and cycles as fast as she can home. Garrett chases after him, and the two break off their friendship after a confrontation.Juli bikes home crying. Bryce continuously tries to talk to her, ringing the doorbell, calling her house, coming to her bedroom

Answer:
Who does Bryce think will bid on him?