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In 1896, Patrick and Gilbert observed that during a prolonged period of sleep deprivation, sleepiness increases and decreases with a period of approximately 24 hours. In 1918, J.S. Szymanski showed that animals are capable of maintaining 24-hour activity patterns in the absence of external cues such as light and changes in temperature. In the early 20th century, circadian rhythms were noticed in the rhythmic feeding times of bees. Extensive experiments were done by Auguste Forel, Ingeborg Beling, and Oskar Wahl to see whether this rhythm was due to an endogenous clock.[citation needed] Ron Konopka and Seymour Benzer isolated the first clock mutant in Drosophila in the early 1970s and mapped the "period" gene, the first discovered genetic determinant of behavioral rhythmicity. Joseph Takahashi discovered the first mammalian circadian clock mutation (clock19) using mice in 1994. However, recent studies show that deletion of clock does not lead to a behavioral phenotype (the animals still have normal circadian rhythms), which questions its importance in rhythm generation.

What gene did Konopka and Benzer map in the early 1970 s?
Answer: "period"
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The state (like its southwestern neighbors) has had close linguistic and cultural ties with Mexico. The state outside the Gadsden Purchase of 1853 was part of the New Mexico Territory until 1863, when the western half was made into the Arizona Territory. The area of the former Gadsden Purchase contained a majority of Spanish-speakers until the 1940s, although the Tucson area had a higher ratio of anglophones (including Mexican Americans who were fluent in English); the continuous arrival of Mexican settlers increases the number of Spanish-speakers.

Are Arizona and New Mexico residents speaking Spanish or English?
Answer: the continuous arrival of Mexican settlers increases the number of Spanish-speakers.
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As of 2004[update], 2532 telephone main lines are in use, a mix of analog (2500) and digital (32) circuits. Satellite communications services are planned.[citation needed] There is one locally based radio station (Radio Norfolk 89.9FM), broadcasting on both AM and FM frequencies. There is also one TV station, Norfolk TV, featuring local programming, plus transmitters for Australian channels ABC, SBS, Imparja Television and Southern Cross Television. The Internet country code top-level domain (ccTLD) is .nf.

How many local radio stations does Norfolk Island have?
Answer:
one