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Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.
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Paragraph: Cancer patients increasingly are having their care guided by gene tumor boards, a new version of the hospital panels that traditionally decided whether surgery, radiation or chemotherapy would be best. These experts study the patient's cancer genes and match treatments to mutations that seem to drive the disease. "We dissect the patient's tumor with what I call the molecular microscope," said Dr. Razelle Kurzrock, who started a board at the University of California, San Diego, where Cairnes is treated. It's the kind of care many experts say we should aim for precision medicine, the right drug for the right person at the right time, guided by genes. There are success stories, but also some failures and many questions: Will gene-guided care improve survival? Does it save money or cost more? What kind of gene testing is best, and who should get it? "I think every patient needs it," especially if cancer is advanced, said Kurzrock, who consults for some gene-medicine companies. "Most people don't agree with me yet. In five years, it may be malpractice not to do genomics." Few people get precision medicine today, said Dr. Eric Topol, head of the Scripps Translational Science Institute. "The only thing that's gone mainstream are the words." HOW IT WORKS NOW If you have a cancer that might be susceptible to a gene-targeting drug, you may be tested for mutations in that gene, such as HER2 for breast cancer. Some breast or prostate cancer patients also might get a multi-gene test to gauge how aggressive treatment should be. Then most patients get usual guideline-based treatments. If there's no clear choice, or if the disease has spread or comes back, doctors may suggest tumor profiling comprehensive tests to see what mutations dominate. That's traditionally been done from a tissue sample, but newer tests that detect tumor DNA in blood liquid biopsies are making profiling more common. The tests cost about $6,000 and many insurers consider them experimental and won't pay. Gene tumor boards analyze what the results suggest about treatment. They focus on oddball cases like a breast cancer mutation in a colon cancer patient, or cancers that have widely spread and are genetically complex. The only options may be experimental drugs or "off-label" treatments medicines approved for different situations. But as tumor profiling grows, it's revealing how genetically diverse many tumors are, and that oddball cases are not so rare, said Dr. John Marshall. He heads the virtual tumor board at Georgetown Lombardi Comprehensive Cancer Center that also serves cancer centers in Pennsylvania, North Carolina, Michigan and Tennessee. "There is a little bit of faith" that testing will show the right treatment, but it's not a sure thing, said Dr. Lee Schwartzberg, who heads one participating center, the West Cancer Center in Memphis. Dr. Len Lichtenfeld, the American Cancer Society's deputy chief medical officer, is optimistic yet wary. Drugs that target BRAF mutations work well for skin cancers called melanomas, but less well for lung or colon cancers. "Just because a mutation occurs it doesn't mean that drug is going to work in that cancer," he said. LUCKY CASES When it does, results can be dramatic. Cairnes' cancer was between her stomach and esophagus, and had spread to her liver, lungs and lymph nodes. Tissue testing found 10 abnormal genes, but on the liquid biopsy only EGFR popped out as a good target. Two drugs aim at that gene but aren't approved for her type of cancer. A tumor board advised trying both Erbitux and Tarceva, the drug her husband also had taken. Within two weeks, she quit using pain medicines. After two months, her liver tumor had shrunk roughly by half. There are signs that cancer may remain, but it is under control. She feels well enough to travel and to take care of her granddaughter. "I'm very, very grateful to have a targeted therapy," Cairnes said. "I cannot expect a better outcome than what we're seeing right now," said her doctor, Shumei Kato. WHAT STUDIES SHOW But is gene-guided treatment better than usual care? French doctors did the first big test, with disappointing results. About 200 patients with advanced cancer were given whatever their doctors thought best or off-label drugs based on tumor profiling. Survival was similar about two months. Another French study, reported in June, was slightly more encouraging on survival but exposed another problem: No drugs exist for many gene flaws. Tests found treatable mutations in half of the 2,000 participants and only 143 got what a tumor board suggested. Some doctors worry that tumor boards' recommending off-label treatments diverts patients from research that would benefit all cancer patients. For example, the American Society of Clinical Oncology's TAPUR study tests off-label drugs and shares results with their makers and federal regulators. LETTING PATIENTS CHOOSE Ann Meffert, who lives on a dairy farm in Waunakee, Wisconsin, endured multiple standard treatments that didn't defeat her bile duct cancer. "She was going to be referred to hospice; there was not much we could do," said Dr. Nataliya Uboha, who took the case to a tumor board at the University of Wisconsin-Madison. The panel gave several options, including off-label treatment, and Meffert chose a study that matches patients to gene-targeting therapies and started on an experimental one last October. "Two weeks in, I started feeling better," she said, and when she saw test results, "I couldn't believe the difference." Many lung spots disappeared and the liver tumor shrank 75 percent. She is not cured, though, and doctors are thinking about next steps. And that could involve a fresh look at her tumor genes. ___ Marilynn Marchione can be followed at @MMarchioneAP __ This Associated Press series was produced in partnership with the Howard Hughes Medical Institute's Department of Science Education. The AP is solely responsible for all content. Claim: Ultra-personal therapy: Gene tumor boards guide cancer care.
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Doctors were just guessing a decade ago when they gave Alison Cairnes' husband a new drug they hoped would shrink his lung tumors. Now she takes it, but the choice was no guesswork. Sophisticated gene tests suggested it would fight her gastric cancer, and they were right.

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Paragraph: The group, calling themselves Caircraft, believe that big aircraft like A380s and A340s, which are grounded due to coronavirus travel restrictions, could be stripped down and refitted with ICU beds and equipment in seven to ten days. Between 100-150 beds could fit on each aircraft depending on the size of the jet under the group's design plans, and it is now waiting for government support for funding and coordination. "We've had various conversations at various levels. And we absolutely appreciate how busy they are with everything else going on," aviation economist Chris Tarry said of contact with government. "It's a question of reaching the right desks at the right time." Tarry has joined entrepreneur Nick Dyne, Jonathan Sackier, Visiting Professor of SurgeryatOxford University's Nuffield Department of Surgical Sciences and others on the plan. The group is also talking to the U.S. government, Canada, Germany and Malaysia about the idea, Dyne said. UK airlines with parked-up widebody jets support the idea, said Dyne without naming them, although they are believed to include British Airways and Virgin Atlantic, as well as a number of UK airports and the UK aviation regulator, the CAA. Britain is bracing for the epidemic to peak in the coming weeks, and is building field hospitals in London, Birmingham, Manchester and Cardiff to bolster its state-run National Health Service (NHS). Under the Caircraft plans, which the group has been working on for a week, the aircraft would first fly to the place where they were to be needed, before being fitted out. They would not move once treating patients. "What we don't want to do is to be a flying hospital. The regulatory issues regarding that are just too great," said Dyne. The group say the advantage of using planes is that not only are they mobile and there are plenty of them now available, but also that their filtered, one-way airflow systems mirror those of an operating theatre. Dyne declined to comment on the how much it would cost to convert each aircraft. Claim: UK group calls for grounded planes to be used as intensive care wards.
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Airlines, airports and regulators have given their backing to a plan to turn large passenger aircraft into intensive care wards during the coronavirus pandemic, a UK-based group working on the idea said on Monday.

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Paragraph: As part of President Barack Obama's healthcare reform law, the efforts center around more than 360 accountable care organizations (ACOs), which are networks of doctors, hospitals and other providers specially organized to help move Medicare away from traditional fee-for-service medicine. The U.S. Centers for Medicare and Medicaid Services (CMS) said preliminary data show that the ACOs produced $380 million in savings vis-a-vis traditional Medicare in 2012 by giving doctors and other healthcare providers the incentive to focus on improved outcomes for patients instead of fees from tests and services. Medicare, the $575 billion government healthcare system for 51 million elderly and disabled beneficiaries, faces growing financial pressures as a result of America's aging population. A mainstay, the trust fund that pays for hospitalization, is expected to be exhausted in 2026. Deficit hawks view Medicare as a future driver of the federal debt and have called for major systemic reforms. But the Obama administration has pursued gradual changes including the reform of care delivery systems. So-called fee-for-service medicine is widely viewed as a cause of rising healthcare costs, because it calls for paying healthcare providers for tests and services that are sometimes unnecessary. Obamacare seeks to tackle costs by exploring ACOs and other new healthcare business models intended to find savings that do not jeopardize care. A main goal is to generate savings large enough to be shared between Medicare and providers. But some experts are skeptical, saying significant cost reductions could be hard to maintain over time. But CMS, an agency within the U.S. Department of Health and Human Services, runs two different ACO programs. In its largest, 54 of 114 ACO networks achieved lower than expected expenditures. But only 29 saw savings big enough to share with providers. All told, the program produced $128 million in net savings for Medicare's trust funds. "Overall, the ACO program's a net saver to the Medicare program," CMS principal deputy administrator Jon Blum told reporters in a conference call. "It's giving us great confidence that this is the right course for the Medicare program and we are confident that it will continue to show quality improvement and cost savings." Officials said the ACOs also achieved a wide range of quality goals. But CMS released no quality statistics. Thursday's government release drew some cautious optimism from the healthcare industry. "Today's report reflects important steps. More work is needed to modernize our antiquated Medicare payment system and base payment on evidence-based quality measures and proven patient outcomes," said Dr. John Noseworthy, chief executive of the Mayo Clinic in Rochester, Minnesota, which is not part of the government's program. "As results of the team-based care models are analyzed, those most effective in driving down health care costs without compromising safety and quality should become part of the healthcare system," he said. Claim: U.S. says results encouraging for healthcare delivery reforms.
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The Obama administration on Thursday reported what it called encouraging results from efforts to reduce healthcare costs and improve the quality of care for more than 5 million Medicare beneficiaries under Obamacare