In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Input: Consider Input: Paragraph: In this study, we report the complete genome sequence of two contemporary human coronavirus OC43 (HCoV-OC43) strains detected in 2003 and 2004, respectively. Comparative genetic analyses of the circulating strains and the prototype HCoV-OC43 strain (ATCC VR759) were performed. Remarkably, a lower than expected similarity is found between the complete genomes and more in particular between the spike genes of the BE03 and BE04 strains. This finding suggests the existence of two genetically distinct HCoV-OC43 strains, circulating in Belgium in 2003 and 2004. Spike gene sequencing of three additional 2003 and two additional 2004 HCoV-OC43 strains, and subsequent phylogenetic analysis confirm this assumption. Compared to the ATCC prototype HCoV-OC43 strain, an important amino acid substitution is present in the potential cleavage site sequence of the spike protein of all contemporary strains, restoring the N-RRXRR-C motif, associated with increased spike protein cleavability in bovine coronaviruses. We here describe specific characteristics associated with circulating HCoV-OC43 strains, and we provide substantial evidence for the genetic variability of HCoV-OC43. D
Title: Circulation of genetically distinct contemporary human coronavirus OC43 strains

Output: True

Input: Consider Input: Paragraph: The role of CC chemokine ligand 3 (CCL3) in activation of dendritic cells (DCs) following mouse hepatitis virus (MHV) infection of the central nervous system (CNS) was examined. The results indicate that CCL3 participates in an effective host response to MHV infection by contributing to CD11c + CD11b + CD8a A DC maturation, activation, and migration to cervical lymph nodes (CLN). Diminished CD8a A DC activation correlated with reduced IFN-g expression by virus-specific T cells accompanied by increased IL-10 production suggesting that CCL3 contributes to an effective host response to viral infection by enhancing the T cell activation potential of DC. D
Title: The CC chemokine ligand 3 regulates CD11c + CD11b + CD8a A dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation

Output: False

Input: Consider Input: Paragraph: Objectives To determine the inhibitory activities of flavonoids against NS2B-NS3 protease of ZIKA virus (ZIKV NS2B-NS3 pro ) expressed in Escherichia coli BL21 (DE3) and their structure activity relationship. Results ZIKV NS2B-NS3 pro was expressed in E. coli BL21(DE3) as a 35 kDa protein. It had a K m of 26 lM with the fluorogenic peptide Dabcyl-KTSAVLQS GFRKME-Edan. The purified ZIKV NS2B-NS3 pro was used for inhibition and kinetic assays to determine the activities of 22 polyphenol compounds. These polyphenol compounds at 100 lM inhibited the activity of ZIKV NS2B-NS3 pro by 6.2-88%. Seven polyphenol compounds had IC 50 ranging from 22 0.2 to 112 5.5 lM. Myricetin showed a mixed type inhibitory pattern against ZIKV NS2B-NS3 pro protease. Its IC 50 value was 22 0.2 lM with a K i value of 8.9 1.9 lM. Conclusion The chemical structure of a polyphenol compound and its inhibitory activity against ZIKV NS2B-NS3 pro can be explored to develop highly selective inhibitors against ZIKV NS2B-NS3 pro .
Title: Inhibitory effect of flavonoids against NS2B-NS3 protease of ZIKA virus and their structure activity relationship
Output: False