Premise:
"Man-made Madrid, which quickly assumed the reigns of Spain's Golden Age, hasn't stopped growing and asserting itself since."
Hypothesis: Madrid did not experience any growth prior to the Golden Age.

it is not possible to tell

Premise:
"Sure, that sounds perfectly neutral."
Hypothesis: That sounds like a pretty skewed stance.

no

Premise:
"The synagogue was the center of Ashkenazi worship until the fighting in 1948, when the building was destroyed and the site became a ruin once more."
Hypothesis: They synagogue influenced Ashkenazi worship until it was destroyed in 1948.
yes