Information: - Yokohama's population of 3.7 million makes it Japan's largest city after the Special Wards of Tokyo. Yokohama developed rapidly as Japan's prominent port city following the end of Japan's relative isolation in the mid-19th century, and is today one of its major ports along with Kobe, Osaka, Nagoya, Hakata, Tokyo, and Chiba. - Geography. Minami Ward is located in eastern Kanagawa Prefecture, and south of the geographic center of the city of Yokohama. Large buildings and apartment complexes are built up along the area surrounding the highways and railways in the Ward; and all other parts of the Ward are residential areas. The oka River is the major river in the Ward, and in spring many cherry blossoms come into full bloom on its banks. Gumy-ji, located in the southern part of the ward, is the oldest Buddhist temple in Yokohama. - Erika Umeda ( Umeda Erika , born on May 24 , 1991 in Minami - ku , Yokohama , Japan ) is a Japanese singer and was a former member of the J - pop group Cute , under Hello ! Project , fashion model signed to ILLUME . She was also a member of Japanese pop girl group ZYX along with Momoko Tsugunaga , Mari Yaguchi , Maimi Yajima , Megumi Murakami , and Saki Shimizu . - History. The prefecture has some archaeological sites going back to the Jmon period (around 400 BCE). About 3,000 years ago, Mount Hakone produced a volcanic explosion which resulted in Lake Ashi on the western area of the prefecture. What object entity has the relation of 'place of birth' with the subject 'erika umeda'? Choices: - center - chiba - japan - kanagawa prefecture - nagoya - of - yokohama
kanagawa prefecture
(Q).
Information: - Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR). - Cycloguanil is a dihydrofolate reductase inhibitor , and is a metabolite of the antimalarial drug proguanil ; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil . However , more recent work has indicated that , while proguanil is synergistic with the drug atovaquone ( as in the combination Malarone ) , cycloguanil is in fact antagonistic to the effects of atovaquone , suggesting that , unlike cycloguanil , proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition . Although cycloguanil is not currently in general use as an antimalarial , the continuing development of resistance to current antimalarial drugs has led to renewed interest in studying the use of cycloguanil in combination with other drugs . - Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the "DHFR" gene. It is found in the q11q22 region of chromosome 5. Bacterial species possess distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. - A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. - Atovaquone (alternative spelling: atavaquone) is a chemical compound that belongs to the class of naphthoquinones. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. It is manufactured in the US in the liquid form, or oral suspension, under the brand name Mepron. What object entity has the relation of 'instance of' with the subject 'cycloguanil'? Choices: - activity - brand - chemical compound - class - dna - electron - enzyme - function - gene - humans - liquid - molecule - species - vitamin - work
(A).
chemical compound