Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Hoping to rebound from a tough loss to the Patriots, the Bills would play their Week 2 home opener in an interconference duel with the Tampa Bay Buccaneers. This would be the first time that Buffalo ever hosted Tampa Bay in a regular season game, having played a preseason game with each other in 1977. In the first quarter, the Bills came out firing as quarterback Trent Edwards completed a 32-yard touchdown pass to wide receiver Lee Evans, safety Donte Whitner returning an interception 76 yards for a touchdown and kicker Rian Lindell making a 31-yard field goal. The Buccaneers would get on the board in the second quarter as quarterback Byron Leftwich completed a 42-yard touchdown pass to tight end Kellen Winslow, while Buffalo replied with Lindell getting a 43-yard field goal. Tampa Bay would close out the half as Leftwich completed an 8-yard touchdown pass to running back Carnell "Cadillac" Williams. After a scoreless third quarter, the Bills began to pull away as Lindell got a 43-yard field goal and Edwards completed a 43-yard touchdown pass to wide receiver Terrell Owens. The Buccaneers tried to rally as Leftwich completed a 6-yard touchdown pass to tight end Jerramy Stevens (with a failed two-point conversion), yet Buffalo closed out the game with Lindell nailing a 20-yard field goal. With the win, the Bills improved to 1-1.
Example Output: Who won against the Bills before this game?

Example Input: The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.
Example Output: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?

Example Input: "To be or not to be".Outside the Bible, these six words are the most famous in all the literature of the world.They were spoken by Hamlet when he was thinking aloud, and they are the most famous words in Shakespeare because Hamlet was speaking not only for himself but for every thinking man and woman.To be or not to be----to live or not to live, to live richly and abundantly and eagerly, or to live dully and meanly and scarcely.A philosopher once wanted to know whether he was alive or not, which is a good question for everyone to put to himself occasionally.He answered it by saying, "I think, therefore I am." But the best definition of existence I ever saw was one written by another philosopher who said, "To be is to be in relations." If this is true, then the more relations a living thing has, the more it is alive.To live abundantly means simply to increase the range and intensity of our relations.Unfortunately, we are so constituted that we get to love our routine.But other than our regular occupation, how much are we alive? If you are interested only in your regular occupation, you are alive only to that extent.So far as other things are concerned----poetry and prose, music, pictures, sports unselfish friendships, politics, international affairs----you are dead. On the contrary, it is true that every time you acquire a new interest----even more, a new accomplishment----you increase your power of life.No one who is deeply interested in different kinds of subjects can remain unhappy.The real is the person who has lost interest. Bacon said that a man dies as often as he loses a friend.But we gain new life by contacts with new friends, and new ideas and thoughts, too.Where your thoughts are, there will be your life also.If your thoughts are limited only to your business, only to your physical welfare, only to your narrow circle of the town in which you live, then you live in a narrow restricted life.But if you are interested in the characters of a good novel, then you are living with those highly interested people; if you listen intently to fine music, you are always away from immediate surroundings and living in a world of passion and imagination. To be or not to be ---- to live intensely and richly, or merely to exist, that depends on ourselves.Let us widen and intensify our relations.While we live, let us live.
Example Output:
What is the main idea of the passage?