In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
Q: Paragraph: Contact-dependent growth inhibition (CDI) is a wide-spread mechanism of inter-bacterial competition mediated by the CdiB/CdiA family of two-partner secretion proteins. CdiA effectors carry diverse C-terminal toxin domains (CdiA-CT), which are delivered into neighboring target cells to inhibit growth. CDI + bacteria also produce CdiI immunity proteins that bind specifically to cognate CdiA-CT toxins and protect the cell from auto-inhibition. Here, we compare the structures of homologous CdiA-CT/CdiI complexes from Escherichia coli EC869 and Yersinia pseudotuberculosis YPIII to explore the evolution of CDI toxin/immunity protein interactions. Both complexes share an unusual -augmentation interaction, in which the toxin domain extends a -hairpin into the immunity protein to complete a sixstranded anti-parallel sheet. However, the specific contacts differ substantially between the two complexes. The EC869 -hairpin interacts mainly through direct H-bond and ion-pair interactions, whereas the YPIII -hairpin pocket contains more hydrophobic contacts and a network of bridging water molecules. In accord with these differences, we find that each CdiI protein only protects target bacteria from its cognate CdiA-CT toxin. The compact -hairpin-binding pocket within the immunity protein represents a tractable system for the rationale design of small molecules to block CdiA-CT/CdiI complex formation. We synthesized a macrocyclic peptide mimic of the -hairpin from EC869 toxin and solved its structure in complex with cognate immunity protein. These latter studies suggest that small molecules could potentially be used to disrupt CDI toxin/immunity complexes. 3 Contact-dependent growth inhibition, CDI; C-terminal toxin of CdiA, CdiA-CT; immunity protein, CdiI;
Title: Diversification of -augmentation interactions between CDI toxin/immunity proteins
A:
True