Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: With thousands of years of history and mythology in its area, prefix = st1 /Athens--named for the olive-tree-loving Athena---is more than a concrete jungle. It's a lovely city decorated by outdoor cafes, pedestrian streets, parks, gardens and plenty of characters. _ The city is connected three sides by Mt Parnitha, Mt Pendeli and Mt Hymettos. WithinAthensthere are no less than eight hills, of which the Acropolis and Lykavitos are the most famous. The hills provide a peaceful rest from the noise of the city. Just about everything of interest to the traveler is within a small area surrounding Plateia Syntagmatos (Syntagma Square). This area is connected with the districts of Plaka to the south, Monastiraki to the west, Kolonaki to the east and Omaonia to the north. Plateia Syntagmatos is dominated by the oldRoalPalaceand is the beating heart of the business district, with luxury hotels, banks and airline offices. Plaka, nestled below the Acropolis, is the old Turkish quarter and virtually all that existed when Athens was declared the capital of independentGreece. Though Plaka is packed with tourists in high season, it's also one of the prettiest and most atmospheric areas of the city. Monastiraki is the market district and a fascinating part of town to wander. Psiri, nearby, is full of stylish cafes and bars and makes a great place to stop for a rest of lunch. Kolonaki, a classy living area, is full of trendy boutiques, art galleries and cafes.

A: If you want to buy something, where will you go?
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Q: TransLink is urging customers to avoid non-essential travel today and to stay home where possible in the difficult weather conditions. TransLink chief executive officer Peter Strachan said bus and train services were continuing to run where possible, however all CityCat and CityFerry services had been cancelled until further notice. "These are extremely difficult conditions for South East Queensland---we are running essential services where possible but safety remains to be the most important," Mr Strachan said. "Severe weather and associated flooding has impacted on all modes of public transport, with bus, ferry and train services all impacted to varying degrees. "If you are planning to use public transport at anytime over the next few days, then I would recommend you check that your intended service is still running." Service disruptions for today include: l City network trains running hourly on all lines. l Bus diversions, delays and cancellations in some regions, particularly across Brisbane, Ipswich and the Sunshine Coast. l CityCat and CityFerry services cancelled. Queensland Rail Chief Executive Officer Paul Scurrah said rising waterways had closed some train lines, and road closures and damage to property throughout the South-East had contributed to a shortage of available rail employees. "We intend to run trains hourly on all lines, similar to the timetable we operate on Christmas Day. We will also be looking to run other additional services to meet demand as required. At this stage we will run services stopping at all stations which will depart at the same time on the hour, however, this is all subject to the weather conditions and the availability of traincrew." Mr Scurrah encouraged all customers to visit the Translink website for specific departure times for their station, and asked for patience in the event of delays. "Queensland Rail appreciates that reduced services may cause disruptions but it is simply unavoidable. We have a dedicated and experienced team monitoring the situation around the clock and will be working to reopen the network as soon as practicably possible," Mr Scurrah said. The latest service disruption information is available on the TransLink website www.translink.com.au.

A: Which means of transport is NOT available during the special period?
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Q: Human alpha-galactosidase A (EC 3.2.1.22; alpha-Gal A) is the lysosomal exoglycosidase responsible for the hydrolysis of terminal alpha-galactosyl residues from glycoconjugates and is the defective enzyme causing Fabry disease (McKusick 301500). An unusally elevated level of plasma alpha-Gal A activity (> 2.5 times the normal mean) was detected in two unrelated normal males and the elevated activities were inherited as X-linked traits in their families. Sequencing of the alpha-Gal A coding region, intron/exon boundaries and 5'-flanking region from the proband identified a single mutation, a G-->A transition 30 nt upstream from the initiation of translation codon in exon 1. The -30G-->A mutation occurred in a putative NF kappa B/Ets consensus binding site that was recently shown to inhibit protein binding to the 5'-untranslated region of the gene, providing a possible explanation for its high activity. To further characterize the mutation, the mRNA and protein expressed by this variant allele were studied. Purified plasma and lymphoblast alpha-Gal A activity from individuals with the -30G-->A mutation had normal physical and kinetic properties. In vitro translation of mRNAs from the cloned normal and high plasma activity alleles resulted in similar levels of alpha-Gal A protein, indicating that this mutation did not enhance translation. These findings suggest that the -30G-->A mutation in the 5'-untranslated region of the alpha-Gal A gene enhances transcription, presumably by interfering with the binding of negatively-acting transcription factors which normally decrease alpha-Gal A expression in various cells. Preliminary studies of the frequency of the -30G-->A mutation in 395 unrelated normal males of mixed ancestry revealed two additional unrelated individuals who had high plasma enzymatic activity and the mutation, confirming the effect of this mutation on enzyme expression and suggesting that about 0.5% of normal individuals have high plasma alpha-Gal A activity due to this variant allele.

A:
Which is the defective protein causing the lysosomal storage disease Fabry?
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