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Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.
What types of vaccines have been phased out?
A: Vaccines made from attenuated whole cells or lysates

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Popes called for crusades to take place elsewhere besides the Holy Land: in Spain, southern France, and along the Baltic. The Spanish crusades became fused with the Reconquista of Spain from the Muslims. Although the Templars and Hospitallers took part in the Spanish crusades, similar Spanish military religious orders were founded, most of which had become part of the two main orders of Calatrava and Santiago by the beginning of the 12th century. Northern Europe also remained outside Christian influence until the 11th century or later, and became a crusading venue as part of the Northern Crusades of the 12th to 14th centuries. These crusades also spawned a military order, the Order of the Sword Brothers. Another order, the Teutonic Knights, although originally founded in the crusader states, focused much of its activity in the Baltic after 1225, and in 1309 moved its headquarters to Marienburg in Prussia.
In what century did the Northern Crusades begin?
A: 12th

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In the West, the ancient Greeks initially regarded the best form of government as rule by the best men. Plato advocated a benevolent monarchy ruled by an idealized philosopher king, who was above the law. Plato nevertheless hoped that the best men would be good at respecting established laws, explaining that "Where the law is subject to some other authority and has none of its own, the collapse of the state, in my view, is not far off; but if law is the master of the government and the government is its slave, then the situation is full of promise and men enjoy all the blessings that the gods shower on a state." More than Plato attempted to do, Aristotle flatly opposed letting the highest officials wield power beyond guarding and serving the laws. In other words, Aristotle advocated the rule of law:
To what did Plato compare a government that follows laws?
A: slave

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The modern literary language is usually considered to date from the time of Alexander Pushkin ( ) in the first third of the 19th century. Pushkin revolutionized Russian literature by rejecting archaic grammar and vocabulary (so-called " " "high style") in favor of grammar and vocabulary found in the spoken language of the time. Even modern readers of younger age may only experience slight difficulties understanding some words in Pushkin's texts, since relatively few words used by Pushkin have become archaic or changed meaning. In fact, many expressions used by Russian writers of the early 19th century, in particular Pushkin, Mikhail Lermontov ( ), Nikolai Gogol ( ), Aleksander Griboyedov ( ), became proverbs or sayings which can be frequently found even in modern Russian colloquial speech.
What kind of difficulties did Gogol have when reading Lermontov's texts?
A:
unanswerable