Instructions: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Input: Question: What dose should you administer orally every 12 hours of a drug whose plasma clearance is equal to 1 L / h if you want to reach an average concentration of 10mg / L equilibrium? Assume complete bioavailability (F = 1):
Options: <1> 120 mg. <2> 12 mg. <3> 200 mg. <4> 10 mg. <5> With this information it is not possible to estimate the dose necessary to reach this equilibrium concentration.
Output:
1