Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis. Three multicenter, randomized, double-masked, placebo-controlled, dose-ranging phase III studies: SHIELD, INSURE, and ENDURE. A total of 118 patients with Behcet's uveitis (SHIELD study); 31 patients with active, noninfectious, non-Behcet's uveitis (INSURE study); and 125 patients with quiescent, noninfectious, non-Behcet's uveitis (ENDURE study) were enrolled. After an initial subcutaneous (s.c.) loading phase in each treatment arm, patients received s.c. maintenance therapy with secukinumab 300 mg every 2 weeks (q2w), secukinumab 300 mg monthly (q4w), or placebo in the SHIELD study; secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the INSURE study; or secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the ENDURE study. Reduction of uveitis recurrence or vitreous haze score during withdrawal of concomitant immunosuppressive medication (ISM). Other end points included best-corrected visual acuity, ISM use (expressed as a standardized ISM score), and safety outcomes. After completion or early termination of each trial, there were no statistically significant differences in uveitis recurrence between the secukinumab treatment groups and placebo groups in any study. Secukinumab was associated with a significant reduction in mean total post-baseline ISM score (P = 0.019; 300 mg q4w vs. placebo) in the SHIELD study. Likewise, secukinumab was associated with a greater median reduction in ISM score versus placebo in the INSURE study, although no statistical analysis of the difference was conducted because of the small sample size. Overall, there was no loss in visual acuity reported in any treatment group during follow-up in all 3 studies. According to descriptive safety statistics, the frequencies of ocular and nonocular adverse events seemed to be slightly higher among secukinumab groups versus placebo across the 3 studies. The primary efficacy end points of the 3 studies were not met. The secondary efficacy data from these studies suggest a beneficial effect of secukinumab in reducing the use of concomitant ISM.
Question: Which molecule is targeted by a monoclonal antibody Secukinumab?
interleukin-17a

Context: A machine is any device that makes work easier by changing a force. When you use a machine, you apply force to the machine. This force is called the input force. The machine, in turn, applies force to an object. This force is called the output force. Recall that work equals force multiplied by distance: Work = Force Distance The force you apply to a machine is applied over a given distance, called the input distance. The force applied by the machine to the object is also applied over a distance, called the output distance. The output distance may or may not be the same as the input distance. Machines make work easier by increasing the amount of force that is applied, increasing the distance over which the force is applied, or changing the direction in which the force is applied. Contrary to popular belief, machines do not increase the amount of work that is done. They just change how the work is done. So if a machine increases the force applied, it must apply the force over a shorter distance. Similarly, if a machine increases the distance over which the force is applied, it must apply less force. Examples of machines that increase force are doorknobs and nutcrackers. Figure 16.8 explains how these machines work. In each case, the force applied by the user is less than the force applied by the machine, but the machine applies the force over a shorter distance. Examples of machines that increase the distance over which force is applied are paddles and hammers. Figure 16.9 explains how these machines work. In each case, the machine increases the distance over which the force is applied, but it reduces the strength of the applied force. Some machines change the direction of the force applied by the user. They may or may not also change the strength of the force or the distance over which it is applied. Two examples of machines that work in this way are claw hammers and the rope systems (pulleys) that raise or lower flags on flagpoles. Figure 16.10 explains how these machines work. In each case, the direction of the force applied by the user is reversed by the machine. How does this make it easier to do the job? An exoskeleton suit may seem like science fiction, turning ordinary humans into super heroes. But wearable robots are moving forward into reality. And for paraplegics, the ability to stand and walk that these machines provide is a super power. QUEST meets Austin Whitney and Tamara Mena, two "Exoskeleton Test Pilots" who are now putting this new technology through its paces. For more information on exoskeleton suits, see [Link] MEDIA Click image to the left or use the URL below. URL: You read above that machines do not increase the work done on an object. In other words, you cant get more work out of a machine than you put into it. In fact, machines always do less work on the object than the user does on the machine. Thats because all machines must use some of the work put into them to overcome friction. How much work? It depends on the efficiency of the machine. Efficiency is the percent of input work that becomes output work. It is a measure of how well a machine reduces friction. Consider the ramp in Figure 16.11. Its easier to push the heavy piece of furniture up the ramp to the truck than to lift it straight up off the ground. However, pushing the furniture over the surface of the ramp creates a lot of friction. Some of the force applied to moving the furniture must be used to overcome the friction. It would be more efficient to use a dolly on wheels to roll the furniture up the ramp. Thats because rolling friction is much less than sliding friction. As a result, the efficiency of the ramp would be greater with a dolly. Efficiency can be calculated with the equation: Efficiency = Output work 100% Input work Consider a machine that puts out 6000 joules of work. To produce that much work from the machine requires the user to put in 8000 joules of work. To find the efficiency of the machine,
Question: force applied by a machine
output force

Context: The police must investigate a series of robberies along a strip of land in the city. The new mayor of the city (Kenneth Mars) assigns Captain Harris (G.W. Bailey) and Lt. Proctor (Lance Kinsey) to the case, but while on stakeout the Wilson gang manages to slip through their fingers.The Mayor wants Harris and Proctor to work with Police Academy head Commandant Lassard (George Gaynes) on apprehending the gang. Lassard assembles a seven-man team consisting of Hightower (Bubba Smith), Tackleberry (David Graf), Jones (Michael Winslow), Hooks (Marion Ramsey), Callahan (Leslie Easterbrook), Fackler (Bruce Mahler), and Lassard's nephew, Nick (Matt McCoy) who transfers from Miami (in the previous film Police Acdemy 5) to the city to remain close to his friends and dull-witted uncle.After distributing flyers as to the information of the Wilson gang and getting nowhere, Nick McCoy stumbles upon a paper heading of an antique diamond heading to a museum, and gets an idea to use it as bait: however the robbers nab the diamond anyway by cutting a hole in the truck and escaping through the sewer system. McCoy then decides to go undercover to get information regarding a possible hideout, but Harris decides to go undercover to get a confession.It turns out that Harris goes undercover as a window washer at a tall building, for which he has a fear of heights, and gets a confession of himself on tape after his loyal but numb-skull lacky, Proctor, accidentally knocks him over the balcony.It is revealed here that the robberies are committed by a group of three dim-witted criminals who do not seem to be able to do this on their own, and it is revealed they are being guided by a literally shadow figure known as the "Mastermind", who speaks to the three behind a wall of glass and uses a voice distortion device. He devises a plan to get the cops out of the way.Commandant Lassard and his men are later suspended after stolen jewellery from the last robbery is planted in Lassard's locker, pending an investigation. The misfit cops decide to clear Lassard's name by nabbing the gang and the ringleader. Accessing data files from a computer, McCoy deduces that the robberies are occurring along a bus route, thus intentionally lowering property values in that part of the city. They also learn that someone must be 'leaking' information to the bad guys, which is why they are always one step ahead of the Police Academy.The Police Academy force finds and does battle with the Wilson gang, while Nick chases the leader. A pursuit follows, which leads to Commissioner Hurst's (George Robertson) office. It is revealed that the Mayor is the "Mastermind" and that Captain Harris has been unwittingly leaking information during his daily meetings with the Mayor. Hurst apologizes and reinstates the force, and a plaque is given to honor the officers' bravery the next day.As the movie closes, Harris is sitting in a chair when a string tying the balloon float is cut, lifting his chair and floating him up into the air as he shouts Proctor's name.
Question: Who chases the leader?
nick