Detailed Instructions: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
Q: Question: Does down-regulation of vascular alpha1-adrenoceptors account for the loss of vascular responsiveness to catecholamines in experimental cholestasis?
Answer: Since the affinity and number of vascular alpha1-adrenoceptors were unchanged in the face of elevated plasma concentrations of catecholamines in the BDL rats, we have concluded that down-regulation of vascular alpha1-adrenoceptors does not account for the vascular adrenergic hyporesponsiveness in experimental cholestasis.
A:
no