Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: The TNF family member receptor activator for NF-B ligand (RANKL) and its receptors RANK and osteoprotegerin are key regulators of bone remodeling but also influence cellular functions of tumor and immune effector cells. In this work, we studied the involvement of RANK-RANKL interaction in NK cell-mediated immunosurveillance of acute myeloid leukemia (AML). Substantial levels of RANKL were found to be expressed on leukemia cells in 53 of 78 (68%) investigated patients. Signaling via RANKL into the leukemia cells stimulated their metabolic activity and induced the release of cytokines involved in AML pathophysiology. In addition, the immunomodulatory factors released by AML cells upon RANKL signaling impaired the anti-leukemia reactivity of NK cells and induced RANK expression, and NK cells of AML patients displayed significantly upregulated RANK expression compared with healthy controls. Treatment of AML cells with the clinically available RANKL Ab Denosumab resulted in enhanced NK cell anti-leukemia reactivity. This was due to both blockade of the release of NK-inhibitory factors by AML cells and prevention of RANK signaling into NK cells. The latter was found to directly impair NK anti-leukemia reactivity with a more pronounced effect on IFN- production compared with cytotoxicity. Together, our data unravel a previously unknown function of the RANK-RANKL molecule system in AML pathophysiology as well as NK cell function and suggest that neutralization of RANKL with therapeutic Abs may serve to reinforce NK cell reactivity in leukemia patients.

Answer: To the ligand of which receptors does Denosumab (Prolia) bind?

Question: The Eagles looked to win their 6th game in a row against the winless 49ers. The Eagles got off to a slow start, only leading 3-0 after the first quarter. Late in the second quarter, the Eagles blew the game open. Carson Wentz found tight end Zach Ertz for a 1-yard touchdown in the back of the end zone off of a bootleg pass, and Jalen Mills intercepted rookie QB C.J. Beathard and returned it 37 yards for a touchdown. The 49ers appeared to have some life in the third quarter, following a Carson Wentz interception, leading to a Matt Breida 22 yard touchdown reception. However, the Eagles responded, with Wentz connecting with Alshon Jeffery for a 53-yard touchdown, putting the game out of reach. The Eagles went on to win 33-10 and advanced to 7-1 on the season. Despite the win, the Eagles played a sloppy game in a rainy afternoon at the Linc.

Answer: Which player had the longest touchdown catch?

Question: Baron Mayer Amschel de Rothschild (29 June 1818 -- 6 February 1874) was an English businessman and politician of the English branch of the Rothschild family.

Answer:
What family lineage was Mayer Amschel de Rothschild part of?