TASK DEFINITION: In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
PROBLEM: Paragraph: This review provides an integrated scenario of the most relevant aspects in the development of useful drugs provided by natural sources and recent advances in the biosynthesis and structural design of antimicrobial peptides. Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial activity against a range of pathogenic viruses, bacteria, and fungi. However, the discovery and development of new antibacterial drugs is a crucial step to overcome the great challenge posed by the emergence of antibiotic resistance. In this review, we outline recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design. In addition, we describe recent progress made to overcome some of the major limitations that have hindered peptide biosynthesis.
Title: The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts

SOLUTION: False

PROBLEM: Paragraph: Next year will mark the 100th anniversary of the Michaelis-Menten equation [1], one of the most important and well known models in enzymology. Remarkable progress in enzymology over the past hundred years has not only provided deep insight into biological processes, but also has dramatically changed our lives. However, because of limitations in available techniques, enzymologists primarily investigate the in vitro properties and catalytic mechanisms of individual enzymes. Thus, they often fail to address a fundamental scientific question: how are biological processes, most of which are chemical reactions catalyzed by enzymes, coordinated in space and time to produce a living organism [2]? Fortunately, applications of new techniques and, in particular, wide acceptance of the idea of systems have enabled enzymologists to begin studying enzymes in the context of dynamic, complicated biological systems in recent years. Many excellent reviews and research articles on enzymology have been published in the past few years. These articles highlight the latest developments in enzymology, and should prove helpful for understanding how to best integrate the idea of systems into enzymology research. In living organisms, protein post-translational modification (PTM) pathways are large and interconnected networks. Via reversible or irreversible covalent modifications, allo-steric regulations of PTM enzymes and cross-talk of PTM pathways, PTM networks enable organisms to respond to stimuli faster than is possible through gene transcription regulation. Therefore, PTM enzymes, as key nodes of biological networks, are a recent focus of attention.
Title: SCIENCE CHINA A glimpse of enzymology within the idea of systems

SOLUTION: False

PROBLEM: Paragraph: Context: The 2-1-1 helpline is a social services innovation that has spread rapidly throughout the U.S. Policy diffusion theory suggests that policymakers seek to reduce uncertainty by anticipating the effects of a proposed innovation through tools such as cost-beneft analyses. Few policy diffusion studies have examined use of information, such as cost-beneft analyses, in the diffusion process. The purpose of this study is to examine how cost-beneft analyses were used during the rapid diffusion of 2-1-1 across states. The paper also describes components of 2-1-1 cost-beneft analyses. Evidence acquisition: In 2011, cost-beneft analyses of 2-1-1 and substantive citations of them were identifed through scholarly key word searches using Academic Search Premier and Web of Science, general Internet searches using Google search terms, and communications with academicians and 2-1-1 practitioners through personal contact and e-mail discussion groups. To be included in this study, documents had to be related to 2-1-1 helplines, present information about their costs and benefts, and be formal documents. The documents were catalogued and analyzed for costbeneft analyses or references to analyses, and stated purpose. Evidence synthesis: Of the 19 documents that met eligibility inclusion criteria, nine were original cost-beneft analyses and ten referenced analyses conducted for other jurisdictions. The diffusion of2-1-1 helplinesin the U.S.hasbeen influenced by interjurisdictionalexchange of cost-beneft analyses, in both the creation of original analyses and/or the referencing of previous work. (Am J Prev Med 2012;43(6S5):S497-S505) Am J Prev Med 2012;43(6S5):S497-S505 S497 S498 Shank / Am J Prev Med 2012;43(6S5):S497-S505 www.ajpmonline.org S502 Shank / Am J Prev Med 2012;43(6S5):S497-S505 www.ajpmonline.org
Title: A Review of the Role of Cost-Benefit Analyses in 2-1-1 Diffusion

SOLUTION:
True