Detailed Instructions: Given a text, write a compressed version of it in a single sentence.
Problem:To determine the best of the available screens, a multi-center trial with a broad demographic mix and a large number of patients subjected to different screens is needed. Further evaluation should be performed of lower cut points for TWEAK, CAGE, and AUDIT.
Solution:
A multi-center trial with broad demographics and many patients doing different screens is needed to determine the best. Further evaluation is needed of lower points for TWEAK, CAGE and AUDIT.