In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Ex Input:
Paragraph: The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy. The overall structures resemble that from other coronaviruses including HKU1, MHV and NL63 reported recently, with the exception of the receptor binding domain (RBD). We captured two states of the RBD with receptor binding region either buried (lying state) or exposed (standing state), demonstrating an inherently flexible RBD readily recognized by the receptor. Further sequence conservation analysis of six human-infecting coronaviruses revealed that the fusion peptide, HR1 region and the central helix are potential targets for eliciting broadly neutralizing antibodies.
Title: ARTICLE Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Ex Output:
False

Ex Input:
Paragraph: Autoregressive distributed lag (ARDL) approach Economic growth Error correction model US air travel and freight demand a b s t r a c t This paper examines the short-and long-run effects of economic growth and market shocks (e.g., 9/11 terrorist attacks, Iraq war, SARS epidemic, and 2008 financial crisis) on air passenger and freight services using an autoregressive distributed lag (ARDL) approach to cointegration. Results show that, in the longrun, both air passenger and freight services tend to increase with economic growth. In the short-run, however, only air passenger service is responsive to economic growth. Finally, only the 9/11 terrorist attacks and the SARS have detrimental effects on air passenger demand both in the short-and long-run, and in the long-run, respectively. However, these market shocks are found to have little impact on air freight demand.
Title: Dynamic relationship between air transport demand and economic growth in the United States: A new look

Ex Output:
False

Ex Input:
Paragraph: publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. thermore, apoptosis may contribute to ethanol-induced liver injury via complement activation. Interferon (IFN) administration is the main therapy for HCV-infected individuals, but still a fraction of them are not completely responsive to the treatment. Several HCV proteins such as core, E2, and NS5A proteins have been demonstrated to attenuate IFN responses through different mechanisms. In the present study, we examined whether HCV NS4B, a membrane-bound protein whose functions are mostly unknown, exerted any effects on IFN-induced antiviral responses. From the reporter assay, we showed that NS4B significantly suppressed IFN-induced activation of IFNstimulated responsive element (ISRE) promoter activity. We further examined the ability of HCV NS4B to confer IFN resistance on VSV, an originally IFN-sensitive virus, by a trans-rescue assay. The viral titer was low when cells were treated with IFN-a, which, however, was significantly increased by HCV NS4B. We also examined the effects of HCV NS4B on the transcription of interferon-stimulated genes (ISGs) by qRT-PCR and found that the IFN-induced expression of ISG15, ISG54, ISG56, and OAS2-p69 was significantly downregulated by NS4B. The results were confirmed by chromatin immunoprecipitation (ChIP) assay . The levels and the activation status of the interferon-stimulated gene factor 3 (ISGF3), known to regulate the IFN pathway, were also noticeably reduced by NS4B. Taken together, these results strongly suggest that, in addition to the above mentioned HCV proteins, HCV NS4B may also play a role in IFN antagonism.
Title: PP2-196 Nonstructural protein 4B of hepatitis C virus inhibits interferon responses Role of fusion activity in cross-presentation of influenza nucleoprotein- derived antigens

Ex Output:
True