Context and question: Karl Marx published the Communist Manifesto in February 1848, with little attention. However, a few days later the French Revolution of 1848 broke out, which replaced the monarchy of Louis Philippe with the Second French Republic. In June 1848, Paris workers, disenchanted with the new government, built barricades and raised red flags. The new government called in the French Army to put down the uprising, the first of many such confrontations between the army and the new worker's movements in Europe.
When did the 19th century workers of Paris construct barricades and hoist red flags to protest their new government?
Answer: June 1848
Context and question: There is no cure for asthma. Symptoms can be prevented by avoiding triggers, such as allergens and irritants, and by the use of inhaled corticosteroids. Long-acting beta agonists (LABA) or antileukotriene agents may be used in addition to inhaled corticosteroids if asthma symptoms remain uncontrolled. Treatment of rapidly worsening symptoms is usually with an inhaled short-acting beta-2 agonist such as salbutamol and corticosteroids taken by mouth. In very severe cases, intravenous corticosteroids, magnesium sulfate, and hospitalization may be required.
How can symptoms be prevented?
Answer: by avoiding triggers, such as allergens and irritants, and by the use of inhaled corticosteroids
Context and question: The clearance of the pathogens, either treatment-induced or spontaneous, it can be influenced by the genetic variants carried by the individual patients. For instance, for genotype 1 hepatitis C treated with Pegylated interferon-alpha-2a or Pegylated interferon-alpha-2b (brand names Pegasys or PEG-Intron) combined with ribavirin, it has been shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in the treatment-induced clearance of the virus. This finding, originally reported in Nature, showed that genotype 1 hepatitis C patients carrying certain genetic variant alleles near the IL28B gene are more possibly to achieve sustained virological response after the treatment than others. Later report from Nature demonstrated that the same genetic variants are also associated with the natural clearance of the genotype 1 hepatitis C virus.
What is the brand name Pegasys for?
Answer:
Pegylated interferon-alpha-2b