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Mutations or deletions of clock gene in mice have demonstrated the importance of body clocks to ensure the proper timing of cellular/metabolic events; clock-mutant mice are hyperphagic and obese, and have altered glucose metabolism. In mice, deletion of the Rev-ErbA alpha clock gene facilitates diet-induced obesity and changes the balance between glucose and lipid utilization predisposing to diabetes. However, it is not clear whether there is a strong association between clock gene polymorphisms in humans and the susceptibility to develop the metabolic syndrome.

Beside obesity, how else does the lack of a circadian clock effect the mice?
Answer: glucose metabolism
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The history of the Bronx during the 20th century may be divided into four periods: a boom period during 190029, with a population growth by a factor of six from 200,000 in 1900 to 1.3 million in 1930. The Great Depression and post World War II years saw a slowing of growth leading into an eventual decline. The mid to late century were hard times, as the Bronx declined 195085 from a predominantly moderate-income to a predominantly lower-income area with high rates of violent crime and poverty. The Bronx has experienced an economic and developmental resurgence starting in the late 1980s that continues into today.

When was the Bronx's boom period?
Answer: 190029
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This change is interesting from a sociolinguistic point of view because it has apparently happened relatively recently, in the 1970s, and was pioneered by older well-educated women from the upper middle classes. The lowering of the diphthongs has long been current in many Dutch dialects, and is comparable to the English Great Vowel Shift, and the diphthongisation of long high vowels in Modern High German, which centuries earlier reached the state now found in Polder Dutch. Stroop theorizes that the lowering of open-mid to open diphthongs is a phonetically "natural" and inevitable development and that Dutch, after having diphthongised the long high vowels like German and English, "should" have lowered the diphthongs like German and English as well.

What linguistic event in English could we parallel with the Dutch lowering of diphthongs?
Answer:
English Great Vowel Shift