In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co. discovered and developed chlorothiazide, which remains the most widely used antihypertensive drug today. This development was associated with a substantial decline in the mortality rate among people with hypertension. The inventors were recognized by a Public Health Lasker Award in 1975 for "the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension".
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): What was the main shortcoming in the drug Hydralazine?
Ah, so.. lost its effectiveness over time

To relieve pressure from the expected German attack into Alsace-Lorraine, Napoleon III and the French high command planned a seaborne invasion of northern Germany as soon as war began. The French expected the invasion to divert German troops and to encourage Denmark to join in the war, with its 50,000-strong army and the Royal Danish Navy. It was discovered that Prussia had recently built defences around the big North German ports, including coastal artillery batteries with Krupp heavy artillery, which with a range of 4,000 yards (3,700 m), had double the range of French naval guns. The French Navy lacked the heavy guns to engage the coastal defences and the topography of the Prussian coast made a seaborne invasion of northern Germany impossible.
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): What did Napoleon III plan to relieve pressure from an expected German attack?
Ah, so.. invasion of northern Germany

The people of Somerset are mentioned in the Anglo-Saxon Chronicle's entry for AD 845, in the inflected form "Sumurstum", and the county is recorded in the entry for 1015 using the same name. The archaic name Somersetshire was mentioned in the Chronicle's entry for 878. Although "Somersetshire" was in common use as an alternative name for the county, it went out of fashion in the late 19th century, and is no longer used possibly due to the adoption of "Somerset" as the county's official name after the establishment of the county council in 1889. As with other counties not ending in "shire," the suffix was superfluous, as there was no need to differentiate between the county and a town within it.
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): When did the county stop using Somersetshire
Ah, so..
it went out of fashion in the late 19th century