Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Input: Consider Input: Abstract: Non-excretor cirrhotic patients, defined by their inability to normally excrete a standard water load, display variable responses to head-out water immersion. The hemodynamic, hormonal, and renal functional status of fifteen such patients were analyzed relative to water excretion during head-out water immersion. Group 1 patients (N = 7) all excreted less than 40% of the water load during immersion, whereas excretion was greater than 40% in all eight patients in Group 2. Group 1 patients, when compared with Group 2, had more ascites, more diuretic resistance, lower serum sodium concentration (125 +/- 2 vs. 130 +/- 1 mEq/liter, P less than 0.05), and more impaired baseline water excretion (12.9 +/- 1.2 vs. 35.9 +/- 5.9% of water load in 5 hr, P less than 0.005). Systemic hemodynamic responses to water immersion were similar in both groups. Glomerular filtration rate and renal plasma flow were significantly more impaired in Group 1 patients (inulin clearance 28 +/- 6 vs. 62 +/- 9 ml/min/1.73 m2, P less than 0.05; para-aminohippurate clearance 212 +/- 35 vs. 357 +/- 37 ml/min, P less than 0.05). Concentrations of plasma vasopressin (1.7 +/- 0.5 vs. 0.8 +/- 0.1 pg/ml, P less than 0.05), renin (8.6 +/- 1.7 vs. 3.8 +/- 0.9 ng/ml/hr, P less than 0.05), aldosterone (82 +/- 14 vs. 39 +/- 10 ng/dl, P less than 0.05) and norepinephrine (1155 +/- 183 vs. 603 +/- 126 pg/ml, P less than 0.05) were all significantly higher in Group 1 than Group 2 patients during water immersion.(ABSTRACT TRUNCATED AT 250 WORDS)
Which is the apt title for the abstract? option1: Factors determining renal response to water immersion in non-excretor cirrhotic patients. option2: Primary amebic meningoencephalitis.

Output: Factors determining renal response to water immersion in non-excretor cirrhotic patients.

Input: Consider Input: Abstract: Healthy male rats were exposed to a chronic ingesta of an isotonic NaCl solution during a period of four months. Two different preparations were utilized to study the effect of this treatment on the active mechanisms of Na+ reabsorption of kidney proximal tubular cells: outermost kidney cortex slices (rich in proximal tubules) and inside-out basolateral plasma membrane vesicles prepared from the same tissue. It was found that the activity of the ouabain-insensitive, Na-pump of basolateral plasma membranes of kidney proximal tubular cells was increased in about 70%, whereas the ouabain-sensitive, Na,K-pump activity did not change with the experimental treatment. These results represent a strong support to the two Na-pump's hypothesis since the treatment affected the Na-pump differentially without affecting the Na,K-pump.
Which is the apt title for the abstract? option1: Effect of a high NaCl diet on the active mechanisms of Na+ extrusion in rat kidney. option2: Cutaneous and subcutaneous metastases of lung cancer. Clinical characteristics.

Output: Effect of a high NaCl diet on the active mechanisms of Na+ extrusion in rat kidney.

Input: Consider Input: Abstract: One of the earliest responses of the thyroid cells to TSH is macropinocytosis with formation of intracellular colloid droplets. We demonstrate here that increasing stimulation with TSH not only elicits a highly individual macropinocytotic response among different follicular cells but that the fraction of TSH-responsive cells is also a function of the TSH dose. After pretreatment with T4, mice and rats were injected ip with bovine TSH and killed 2 h later. The macropinocytotic response to TSH was evaluated on periodic acid-Schiff-stained 3-microns sections of the thyroids in terms of droplet number per 25 follicles and, in addition, by assessing recruitment, i.e. percentage of droplet-containing cells. Both variables increased with increasing TSH stimulation until they reached a plateau at about 9 mU TSH in mice and at about 300 mU TSH in rats: the percentage of droplet-containing cells gradually increased in mice from 2% (no TSH) to 67% (9 mU TSH) and in rats from 11% (no TSH) to 54% (300 mU TSH). Overall pinocytotic response as well as thyrocyte recruitment could be modified by extra- and intrathyroidal factors: for example, pretreatment of the mice with an iodine-deficient diet increased the maximal percentage of droplet containing cells to nearly 90%. Obviously, two separate components of the macropinocytotic response of the thyroid gland to TSH can be distinguished: the first is the gradually increasing fraction of droplet-containing cells, the second is the well known increase of the number of colloid droplets in each TSH-responsive cell with progressive TSH stimulation. Recruitment of thyrocytes with a gradually increasing natural threshold to a hormonal stimulus appears to be a fundamental mechanism in the thyroid gland and possibly in other organs.
Which is the apt title for the abstract? option1: Progressive recruitment of follicular cells with graded secretory responsiveness during stimulation of the thyroid gland by thyrotropin. option2: Child abuse and recurrent infant apnea.
Output: Progressive recruitment of follicular cells with graded secretory responsiveness during stimulation of the thyroid gland by thyrotropin.