Given a scientific passage and an answer, generate a question for the given answer.

Let me give you an example: Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
The answer to this example can be: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Here is why: The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.

OK. solve this:
Passage: Hundreds of species of birds have gone extinct as a result of human actions. A well-known example is the passenger pigeon. It was once the most common bird in North America, but over-hunting and habitat destruction led to its extinction in the 1800s. Habitat destruction and use of the pesticide DDT explain the recent extinction of the dusky seaside sparrow. This native Florida bird was declared extinct in 1990. Answer: human actions
Answer:
Which single most factor is responsible for the extinction of hundreds of species of birds?