Instructions: Given a passage and a query based on the passage, generate an unambiguous, concise and simple answer to the query from information in the passage. Note that the answer may not be present in exact form.
Input: Polyglandular Autoimmune Syndrome: 1 Polyglandular Autoimmune Syndrome: Introduction. 2 Symptoms. 3 Causes. 4 Treatments. 5 Misdiagnosis. 6 Full Contents list. polyglandular autoimmune syndrome; PGA syndrome type 1; autoimmune polyendocrinopathy type 1; autoimmune-polyendocrine-candidiasis-ectodermal dystrophy syndrome; Disorder Subdivisions. None; General Discussion. APS-1 is a rare and complex inherited disorder of immune-cell dysfunction with multiple autoimmunities. It presents as a constellation of symptoms and side-effects with potentially life-threatening endocrine gland and gastro-intestinal Schmidt Syndrome. DEFINITION. Schmidt syndrome refers to the combination of autoimmune adrenal insufficiency (Addison's disease) with autoimmune hypothyroidism and/or type 1 diabetes mellitus (T1DM), and is part of a larger syndrome known as autoimmune polyendocrine syndrome type II or polyglandular autoimmune syndrome type II (PAS II). Autoimmune polyendocrine syndrome type 1 (APS-1), also known as autoimmune polyendocrinopathy-candidiasisectodermal dystrophy/dysplasia (APECED), autoimmune polyglandular syndrome type 1, Whitaker syndrome, or candidiasis-hypoparathyroidismAddison's disease syndrome, is a subtype of autoimmune polyendocrine syndrome (autoimmune polyglandular syndrome) in which multiple endocrine glands dysfunction as a result of autoimmunity. MedlinePlus (7 links) 1 Encyclopedia: Addison's Disease. 2 Encyclopedia: Autoimmune Disorders. 3 Encyclopedia: Cutaneous Candidiasis. 4 Encyclopedia: Hypoparathyroidism. 5 Health Topic: Addison Disease. 6 Health Topic: Autoimmune Diseases. 7 Health Topic: Endocrine Diseases. Summary Summary. Autoimmune polyglandular syndrome type 1 is an inherited autoimmune condition that affects many of the body's organs. Symptoms often begin in childhood or adolescence and may include mucocutaneous candidiasis, hypoparathyroidism, and Addison disease. Affected individuals typically have at least two of these features, and many have all three. Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing glands. This condition is characterized by the presence of Addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. Affected individuals may also have problems with other endocrine glands. Autoimmune polyendocrine syndrome is caused by defects in the autoimmune regulator (AIRE) gene. This gene plays a critical role in the body's ability to distinguish between its own proteins and cells and those of bacteria and viruses. As a result, the body attacks its own healthy tissue. Myasthenia gravis: Sometimes this disorder can be associated with autoimmune polyendocrine syndrome type II. Myasthenia gravis is a chronic neuromuscular disease characterized by weakness and abnormally rapid fatigue of the voluntary muscles, with improvement following rest. Treatments for Polyglandular Autoimmune Syndrome. 1 Treatment depends on which endocrine gland is affected: 2 Pancreatic dysfunction will require insulin. 3 Adrenal dysfunction will require cortisol. 4 Thyroid hormone dysfunction will require thyroid hormone replacement. 5 more treatments...". Query: autoimmune polyendocrine syndrome symptoms
Output:
Autoimmune polyendocrine syndrome is a rare and complex inherited disorder of immune-cell dysfunction with multiple autoimmunities.