QUES: Some of these estimates also take into account the opportunity cost of investing capital many years before revenues are realized (see Time-value of money). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A direct consequence within the pharmaceutical industry value chain is that major pharmaceutical multinationals tend to increasingly outsource risks related to fundamental research, which somewhat reshapes the industry ecosystem with biotechnology companies playing an increasingly important role, and overall strategies being redefined accordingly. Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop.
What accounts for nearly half of the costs to develop drugs?

ANS: opportunity cost of investing capital

QUES: Winter, and a deteriorating supply situation on both sides of troops and materiel, led to a halt in ground operations. Sevastopol remained invested by the allies, while the allied armies were hemmed in by the Russian army in the interior. On 14 November a storm sank thirty allied transport ships including HMS Prince which was carrying a cargo of winter clothing.:435 The storm and heavy traffic caused the road from the coast to the troops to disintegrate into a quagmire, requiring engineers to devote most of their time to its repair including quarrying stone. A tramroad was ordered. It arrived in January with a civilian engineering crew, however it was March before it was sufficiently advanced to be of any appreciable value.:439 An Electrical telegraph was also ordered, but the frozen ground delayed its installation until March, when communications from the base port of Balaklava to the British HQ was established. The Pipe-and-cable-laying plough failed because of the hard frozen soil, but even so 21 miles of cable were laid.:449
What was the HMS Prince carrying when it sunk?

ANS: a cargo of winter clothing

QUES: The collation of all known variants of a text is referred to as a variorum, namely a work of textual criticism whereby all variations and emendations are set side by side so that a reader can track how textual decisions have been made in the preparation of a text for publication. The Bible and the works of William Shakespeare have often been the subjects of variorum editions, although the same techniques have been applied with less frequency to many other works, such as Walt Whitman's Leaves of Grass, and the prose writings of Edward Fitzgerald.
Leaves of Grass did not undergo what process?

ANS: unanswerable

QUES: Technology magazine T3 gave the Super Slim model a positive review, stating the console is almost "nostalgic" in the design similarities to the original "fat" model, "While we don't know whether it will play PS3 games or Blu-ray discs any differently yet, the look and feel of the new PS3 Slim is an obvious homage to the original PS3, minus the considerable excess weight. Immediately we would be concerned about the durability of the top loading tray that feels like it could be yanked straight out off the console, but ultimately it all feels like Sony's nostalgic way of signing off the current generation console in anticipation for the PS4."
According to T3, what was the main differentiator between the "fat" PS3 and the Super Slim?

ANS:
weight