In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

[EX Q]: Paragraph: The SARS 3C-like proteinase (SARS-3CLpro), which is the main proteinase of the SARS coronavirus, is essential to the virus life cycle. This enzyme has been shown to be active as a dimer in which only one protomer is active. However, it remains unknown how the dimer structure maintains an active monomer conformation. It has been observed that the Ser139-Leu141 loop forms a short 3 10 -helix that disrupts the catalytic machinery in the inactive monomer structure. We have tried to disrupt this helical conformation by mutating L141 to T in the stable inactive monomer G11A/R298A/Q299A. The resulting tetra-mutant G11A/L141T/R298A/Q299A is indeed enzymatically active as a monomer. Molecular dynamics simulations revealed that the L141T mutation disrupts the 3 10 -helix and helps to stabilize the active conformation. The coil-3 10 -helix conformational transition of the Ser139-Leu141 loop serves as an enzyme activity switch. Our study therefore indicates that the dimer structure can stabilize the active conformation but is not a required structure in the evolution of the active enzyme, which can also arise through simple mutations.
Title: Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity OPEN
[EX A]: True

[EX Q]: Paragraph: Purpose of review-New respiratory viruses have been discovered in recent years and new molecular diagnostic assays have been developed that improve our understanding of respiratory virus infections. This article will review the changing epidemiology of these viruses after hematopoietic stem cell and solid organ transplantation. Recent findings-Respiratory viruses are frequently detected in transplant recipients. A number of viruses have been newly discovered or emerged in the last decade, including human metapneumovirus, human bocavirus, new human coronaviruses and rhinoviruses, human polyomaviruses, and a new 2009 pandemic strain of influenza A/H1N1. The potential for these viruses to cause lower respiratory tract infections after transplantation varies, and is greatest for human metapneumovirus and H1N1 influenza, but appears to be limited for the other new viruses. Acute and long term complications in hematopoietic and solid organ transplant recipients are active areas of research. Summary-Respiratory viral infections are frequently associated with significant morbidity following transplantation and are therefore of great clinical and epidemiologic interest. As new viruses are discovered, and more sensitive diagnostic methods are developed, defining the full impact of emerging respiratory viruses in transplant recipients must be elucidated by welldesigned clinical studies.
Title: Changing Epidemiology of Respiratory Viral Infections in Hematopoietic Cell Transplant Recipients and Solid Organ Transplant Recipients
[EX A]: False

[EX Q]: Paragraph: In this supplementary material we show how our methodology can be implemented for a different hospital ward to that in [1, Figure 2 ]. We consider a hospital ward with six rooms with patients allocated across these rooms in an asymmetrical way. In particular, rooms 1, 3 and 5 contain one patient each, while rooms 2, 4 and 6 contain three patients each. We consider a number of ventilation settings (SA, SB, SC and SD), and carry out a number of numerical simulations to explore how airflow dynamics interplay with other factors related to infection spread, such as outbreak detection. The main aim is: (i) to show how our methodology can easily be extended to any hospital ward structure by appropriately modifying the ventilation matrix V; and (ii) to show how, while some of our conclusions in [1] seem to be valid also for the hospital ward structure considered in this supplementary material, others might highly depend on the particular ward structure under study.
Title: A multicompartment SIS stochastic model with zonal ventilation for the spread of nosocomial infections: detection, outbreak management and infection control Supplementary Material
[EX A]:
True