Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: The actions of benzodiazepines are due to the potentiation of the neural inhibition that is mediated by gamma-aminobutyric acid (GABA). Practically all effects of the benzodiazepines result from their actions on the ionotropic GABA(A) receptors in the central nervous system. Benzodiazepines do not activate GABA(A) receptors directly but they require GABA. The main effects of benzodiazepines are sedation, hypnosis, decreased anxiety, anterograde amnesia, centrally mediated muscle relaxation and anti-convulsant activity. In addition to their action on the central nervous system, benzodiazepines have a dose-dependent ventilatory depressant effect and they also cause a modest reduction in arterial blood pressure and an increase in heart rate as a result of a decrease of systemic vascular resistance. The four benzodiazepines, widely used in clinical anaesthesia, are the agonists midazolam, diazepam and lorazepam and the antagonist flumazenil. Midazolam, diazepam and flumazenil are metabolized by cytochrome P450 (CYP) enzymes and by glucuronide conjugation whereas lorazepam directly undergoes glucuronide conjugation. CYP3A4 is important in the biotransformation of both midazolam and diazepam. CYP2C19 is important in the biotransformation of diazepam. Liver and renal dysfunction have only a minor effect on the pharmacokinetics of lorazepam but they slow down the elimination of the other benzodiazepines used in clinical anaesthesia. The duration of action of all benzodiazepines is strongly dependent on the duration of their administration. Based on clinical studies and computer simulations, midazolam has the shortest recovery profile followed by lorazepam and diazepam. Being metabolized by CYP enzymes, midazolam and diazepam have many clinically significant interactions with inhibitors and inducers of CYP3A4 and 2C19. In addition to pharmacokinetic interactions, benzodiazepines have synergistic interactions with other hypnotics and opioids. Midazolam, diazepam and lorazepam are widely used for sedation and to some extent also for induction and maintenance of anaesthesia. Flumazenil is very useful in reversing benzodiazepine-induced sedation as well as to diagnose or treat benzodiazepine overdose.
Question: Which drug should be used as an antidote in benzodiazepine overdose?

A: flumazenil
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Q: Context: Sedimentary rocks follow certain rules. 1. Sedimentary rocks are formed with the oldest layers on the bottom and the youngest on top. 2. Sediments are deposited horizontally, so sedimentary rock layers are originally horizontal, as are some vol- canic rocks, such as ash falls. 3. Sedimentary rock layers that are not horizontal are deformed. Since sedimentary rocks follow these rules, they are useful for seeing the effects of stress on rocks. Sedimentary rocks that are not horizontal must have been deformed. You can trace the deformation a rock has experienced by seeing how it differs from its original horizontal, oldest- on-bottom position. This deformation produces geologic structures such as folds, joints, and faults that are caused by stresses. Youre standing in the Grand Canyon and you see rocks like those in the Figure 1.1. Using the rules listed above, try to figure out the geologic history of the geologic column. The Grand Canyon is full mostly of sedimentary rocks, which are important for deciphering the geologic history of a region. In the Grand Canyon, the rock layers are exposed like a layer cake. Each layer is made of sediments that were deposited in a particular environment - perhaps a lake bed, shallow offshore region, or a sand dune. (a) The rocks of the Grand Canyon are like a layer cake. (b) A geologic column showing the rocks of the Grand Canyon. In this geologic column of the Grand Canyon, the sedimentary rocks of groups 3 through 6 are still horizontal. Group 2 rocks have been tilted. Group 1 rocks are not sedimentary. The oldest layers are on the bottom and youngest are on the top. The ways geologists figure out the geological history of an area will be explored more in the chapter Earth History. Click image to the left or use the URL below. URL:
Question: the classic location to see layer cake geology is

A: the grand canyon
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Q: Context: One day, a brave jackal came to the river to drink some water. He saw a lion looking weak and tired, and asked, "What is the matter, King of the Jungle?" The lion told the jackal his story. The jackal felt sorry for the lion. He pulled and pulled at the lion's tail until the lion became free. The lion was very happy and said, "Thank you so much for helping me. I thought I would die! You are my friend for life! I would like you to come and live with me. From now on, I will hunt and share my food with you." The jackal moved in with the lion's family and had a wonderful time. Soon, the lion had children of his own and so did the jackal. The lioness was not happy about the friendship. She complained to her children. Her children complained to the jackal's children; the jackal's children complained to their mother and their mother complained to the jackal. The jackal was upset and told the lion, "You told me to live with you. If you don't like it any more, you should have said so yourself." The lion was shocked and said, "This is not true. I've never complained about you. I still want you to continue staying with me." The jackal said, "We understand each other. But our families don't. Perhaps it is better for us to live apart, but continue meeting each other when we are free. We can even hunt together!" The two families parted, but the lion and the jackal met often and remained friends for the rest of their lives. From the above paragraphs, we can conclude that in order to keep our good friendship, we have to give something up or give in in some particular cases. However, we can never give up or destroy our families. What do you think of it?
Question: How was the lion when the jackal first met him?

A:
weak and tired.
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