Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Q: Abstract: Surgical management of major venous injuries remains controversial. The medical records of 184 patients with major venous injury were reviewed. Forty-three patients had isolated venous injury; 31 of 43 patients (72%) underwent ligation to treat their vein injury. Another 141 patients had combined arterial and venous injury; 117 of these patients (83%) had ligation. Injured were the inferior vena cava, iliac, femoral, popliteal, distal leg, and arm veins; all patients underwent surgical exploration. Arterial injuries were repaired by standard techniques and venous injuries were either ligated or repaired by end-to-end or lateral phleborrhaphy. Adjunctive fasciotomy was used when clinically indicated. The patients were followed up for 1 month to 9 years. No permanent sequelae of venous ligation were identified. Transient extremity edema developed in up to 32% of patients, regardless of whether vein ligation or repair was performed. This edema resolved completely within 12 weeks of the injury. No extremity was lost after ligation of a venous injury. Although it may be ideal to repair all venous vascular injuries, selective management reflecting mechanism of injury, blood loss, anesthesia requirements, associated organ injury, and other concerns may mitigate against extensive venous repair.
Which is the apt title for the abstract? option1: Venous injury: to repair or ligate, the dilemma [published erratum appears in J Vasc Surg 1987 Apr;5(4):565] option2: Expired ipecac syrup efficacy.

A: Venous injury: to repair or ligate, the dilemma [published erratum appears in J Vasc Surg 1987 Apr;5(4):565]
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Q: Abstract: A prospective clinical trial was conducted to estimate the rise in serum glucose level after an intravenous bolus of 50 ml of 50% dextrose solution (D-50) in the emergency department setting. Fifty one subjects with altered levels of consciousness were studied. Of these, 23 patients were known diabetics, and 28 were not diabetic. The change in glucose level for the total study group ranged from a low of 37 mg/dl to a high of 370 mg/dl, with a mean of 166 +/- 77 mg/dl. The mean for the diabetic and non-diabetic groups were 177 +/- 80 mg/dl and 154 +/- 75 mg/dl. These results suggest that serum glucose levels cannot be quantitatively predicted after a single intravenous bolus of D-50.
Which is the apt title for the abstract? option1: Serum glucose changes after administration of 50% dextrose solution: pre- and in-hospital calculations. option2: Recognition of protein apparently specific to odontogenic keratocyst fluids.

A: Serum glucose changes after administration of 50% dextrose solution: pre- and in-hospital calculations.
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Q: Abstract: Early cellular events in the malignant transformation of melanocytes to melanoma are virtually unknown. In vitro investigation of this phenomenon has been hampered by the fastidious nature of the human epidermal melanocyte, which has proven difficult to cultivate. The present study compares responsiveness of cultured human epidermal melanocytes and established melanoma cell lines to serum, cholera toxin, and melanocyte growth factor (MGF), three established melanocyte mitogens. Four of four established human melanoma lines were substantially stimulated by fetal bovine serum, as were newborn foreskin-derived epidermal melanocytes. In contrast, none of the four melanoma lines responded to hypothalamic preparations containing MGF that consistently produced an approximately 30-fold increase in newborn melanocyte cell yield over a 2-week period. Cholera toxin, required for successful establishment of primary melanocyte cultures, had small and variable effects on the melanoma lines, with slight stimulation in one case, moderate inhibition in another, and essentially no effect in two others. These data suggest that transformation of epidermal melanocytes to melanoma often involves at least one phenotypic change resulting in escape from MGF regulation and another associated with insensitivity to cyclic AMP modulation; while at least some of the pathways conferring serum dependence are unaltered. Improved culture systems for the human epidermal melanocyte should facilitate further studies into the mechanism of its malignant conversion and may provide useful insights for the prevention and treatment of human melanoma.
Which is the apt title for the abstract? option1: Relative responsiveness of cultured human epidermal melanocytes and melanoma cells to selected mitogens. option2: A new subunit of the human T-cell antigen receptor complex.

A:
Relative responsiveness of cultured human epidermal melanocytes and melanoma cells to selected mitogens.
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