instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: The Islands of Hawaii Hawaii The "Big Island" of Hawaii is a paradise playground where visitors can enjoy a popular lifestyle and at the same time, witness the attraction of nature: thousands of square miles form a wonderland, featuring breathtaking beaches, forests, snow-covered mountains and amazing active volcanoes. A visit to Volcanoes National Park, which has been described as a true wonder of the world, is a must. It is the state's biggest attraction. Accommodations Seasons Resort Hualalai from $ 205.00Fairmont Orchid: from $108.00 Sightseeing and Experiences Circle Island Tour: from $48.00 Kauai The beautiful landscape of Kauai has led to it being called the "Garden Isle", but it is also referred to as the "Island of discovery", and with good reason - a land of striking natural contrasts just waiting to be explored. Green mountains, a breathtaking coastline and white sand beaches combine to make it one of the world's most relaxing locations. Accommodations Grand Hyatt Kauai: from $ 101.00Sheraton Kauai Resort: from $ 79.00 Maui Voted the "World's Best Island", Maui is widely regarded as one of the most romantic destinations on earth. It is known as the "Valley Isle" and was the ancient playground for Hawaiian royalty. The island is largely rural with a small and wonderful population and a host of attractions and nature wonders. Accommodations Hyatt Regency Maui Resort & Spa: from $ 87.00 Sheraton Maui: from $ 99.00 Oahu Oahu has a unique rhythm, filling the air with sweet fragrances , music and language: from lovely beaches and amazing nightlife to beautiful rainforests and quiet valleys. Adventure, history, romance, discovery--Oahu waits for you. Accommodations Halekulani: from $ 121.00 Hilton Hawaiia: Village: from $ 73.00 Sightseeing and Experiences Royal Circle Island Tour: from $ 34.00 Paradise Cove Lu'au: $ 44.00 # All prices are based on per person per night.
Question: Which island was the ancient playground for Hawaiian royalty?
answer:
maui

question:
Context: Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called the Philadelphia (Ph) chromosome. In 2-10% of the cases, this chimeric gene is generated by variant rearrangements, involving 9q34, 22q11, and one or several other genomic regions. All chromosomes have been described as participating in these variants, but there is a marked breakpoint clustering to chromosome bands 1p36, 3p21, 5q13, 6p21, 9q22, 11q13, 12p13, 17p13, 17q21, 17q25, 19q13, 21q22, 22q12, and 22q13. Despite their genetically complex nature, available data indicate that variant rearrangements do not confer any specific phenotypic or prognostic impact as compared to CML with a standard Ph chromosome. In most instances, the t(9;22), or a variant thereof, is the sole chromosomal anomaly during the chronic phase (CP) of the disease, whereas additional genetic changes are demonstrable in 60-80% of cases in blast crisis (BC). The secondary chromosomal aberrations are clearly nonrandom, with the most common chromosomal abnormalities being +8 (34% of cases with additional changes), +Ph (30%), i(17q) (20%), +19 (13%), -Y (8% of males), +21 (7%), +17 (5%), and monosomy 7 (5%). We suggest that all these aberrations, occurring in >5% of CML with secondary changes, should be denoted major route abnormalities. Chromosome segments often involved in structural rearrangements include 1q, 3q21, 3q26, 7p, 9p, 11q23, 12p13, 13q11-14, 17p11, 17q10, 21q22, and 22q10. No clear-cut differences as regards type and prevalence of additional aberrations seem to exist between CML with standard t(9;22) and CML with variants, except for slightly lower frequencies of the most common changes in the latter group. The temporal order of the secondary changes varies, but the preferred pathway appears to start with i(17q), followed by +8 and +Ph, and then +19. Molecular genetic abnormalities preceding, or occurring during, BC include overexpression of the BCR/ABL transcript, upregulation of the EVI1 gene, increased telomerase activity, and mutations of the tumor suppressor genes RB1, TP53, and CDKN2A. The cytogenetic evolution patterns vary significantly in relation to treatment given during CP. For example, +8 is more common after busulfan than hydroxyurea therapy, and the secondary changes seen after interferon-alpha treatment or bone marrow transplantation are often unusual, seemingly random, and occasionally transient. Apart from the strong phenotypic impact of addition of acute myeloid leukemia/myelodysplasia-associated translocations and inversions, such as inv(3)(q21q26), t(3;21)(q26;q22), and t(15;17)(q22;q12-21), in CML BC, only a few significant differences between myeloid and lymphoid BC are discerned, with i(17q) and TP53 mutations being more common in myeloid BC and monosomy 7, hypodiploidy, and CDKN2A deletions being more frequent in lymphoid BC. The prognostic significance of the secondary genetic changes is not uniform, although abnormalities involving chromosome 17, e.g., i(17q), have repeatedly been shown to be ominous. However, the clinical impact of additional cytogenetic and molecular genetic aberrations is most likely modified by the treatment modalities used.
Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
answer:
the bcr/abl gene fusion

question:
Context: An infectious disease is a disease that is caused by a pathogen. A pathogen is an organism or virus that causes disease in another living thing. Pathogens are commonly called germs. Watch this dramatic video for an historic perspective on infectious diseases and their causes: . MEDIA Click image to the left or use the URL below. URL: There are several types of pathogens that cause diseases in human beings. They include bacteria, viruses, fungi, and protozoa. The different types are described in Table 21.1. The table also lists several diseases caused by each type of pathogen. Many infectious diseases caused by these pathogens can be cured with medicines. For example, antibiotic drugs can cure most diseases caused by bacteria. Different pathogens spread in different ways. Some are easy to catch. Others are much less contagious. Some pathogens spread through food or water. When harmful bacteria contaminate food, they cause foodborne illness, commonly called food poisoning. An example of a pathogen that spreads through water is the protozoan named Giardia lamblia, described in Table 21.1. It causes a disease called giardiasis. Some pathogens spread through sexual contact. In the U.S., the pathogen most commonly spread this way is HPV, or human papillomavirus. It may cause genital warts and certain types of cancer. A vaccine can prevent the spread of this pathogen. Many pathogens spread by droplets in the air. Droplets are released when a person coughs or sneezes, as you can see in Figure 21.2. The droplets may be loaded with pathogens. Other people may get sick if they breathe in the pathogens on the droplets. Viruses that cause colds and flu can spread this way. Other pathogens spread when they are deposited on objects or surfaces. The fungus that causes athletes food spreads this way. For example, you might pick up the fungus from the floor of a public shower. You can also pick up viruses for colds and flu from doorknobs and other commonly touched surfaces. Still other pathogens are spread by vectors. A vector is an organism that carries pathogens from one person or animal to another. Most vectors are insects such as ticks or mosquitoes. They pick up pathogens when they bite an infected animal and then transmit the pathogens to the next animal they bite. Ticks spread the bacteria that cause Lyme disease. Mosquitoes spread the protozoa that cause malaria. What can you do to avoid infectious diseases? Eating well and getting plenty of sleep are a good start. These habits will help keep your immune system healthy. With a healthy immune system, you will be able to fight off many pathogens. Vaccines are available for some infectious diseases. For example, there are vaccines to prevent measles, mumps, whooping cough, and chicken pox. These vaccines are recommended for infants and young children. You can also take the following steps to avoid picking up pathogens or spreading them to others. Watch this video for additional information on preventing the spread of infectious diseases: MEDIA Click image to the left or use the URL below. URL: Wash your hands often with soap and water. Spend at least 20 seconds scrubbing with soap. See Figure 21.3 for effective hand washing tips. Avoid touching your eyes, nose, or mouth with unwashed hands. Avoid close contact with people who are sick. This includes kissing, hugging, shaking hands, and sharing cups or eating utensils. Cover your coughs and sneezes with a tissue or shirt sleeve, not your hands. Disinfect frequently touched surfaces, such as keyboards and doorknobs, especially if someone is sick. Stay home when you are sick. The best way to prevent diseases spread by vectors is to avoid contact with the vectors. For example, you can wear long sleeves and long pants to avoid tick and mosquito bites. Using insect repellent can also reduce your risk of insect bites.
Question: Which human infectious disease can be prevented with a vaccine?
answer:
genital warts