Please answer the following question: Information: - France, officially the French Republic, is a country with territory in western Europe and several overseas regions and territories. The European, or metropolitan, area of France extends from the Mediterranean Sea to the English Channel and the North Sea, and from the Rhine to the Atlantic Ocean. Overseas France include French Guiana on the South American continent and several island territories in the Atlantic, Pacific and Indian oceans. France spans and had a total population of almost 67 million people as of January 2017. It is a unitary semi-presidential republic with the capital in Paris, the country's largest city and main cultural and commercial centre. Other major urban centres include Marseille, Lyon, Lille, Nice, Toulouse and Bordeaux. - A railcar, in British English and Australian English, is a self-propelled railway vehicle designed to transport passengers. The term "railcar" is usually used in reference to a train consisting of a single coach (carriage, car), with a driver's cab at one or both ends. Some railways, e.g., the Great Western Railway, used the term Railmotor. If it is able to pull a full train, it is rather called a motor coach or a motor car. - The Esculape was a French automobile manufactured only in 1899 . Advertised as being '' worked by an improved De Dion - Bouton motor , strengthened by a water current '' , it was said by its Paris - based makers , the Automobile Union , to be '' fast , silent , and vibrationless '' . - Marquis Jules Felix Philippe Albert de Dion de Wandonne (9 March 1856 19 August 1946) was a pioneer of the automobile industry in France. - De Dion-Bouton was a French automobile manufacturer and railcar manufacturer operating from 1883 to 1932. The company was founded by the "Marquis" Jules-Albert de Dion, Georges Bouton, and Bouton's brother-in-law Charles Trepardoux. - Paris (French: ) is the capital and most populous city of France. It has an area of and a population in 2013 of 2,229,621 within its administrative limits. The city is both a commune and department, and forms the centre and headquarters of the Ile-de-France, or Paris Region, which has an area of and a population in 2014 of 12,005,077, comprising 18.2 percent of the population of France. - Ile-de-France (, , "Island of France"), also known as the "region parisienne" ("Parisian Region"; see Etymology), is one of the 18 regions of France, and includes the city of Paris. It covers 12012 square kilometers (4638 square miles), and has its own regional council and president. It has a population of 12,005,077 as of January 2014, or 18.2 percent of the population of France. What entity does 'esculape' has the relation 'instance of' with?
A:
automobile manufacturer