Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Although peak finding in next-generation sequencing (NGS) datasets has been addressed extensively, there is no consensus on how to analyze and process biological replicates. Furthermore, most peak finders do not focus on accurate determination of enrichment site widths and are not widely applicable to different types of datasets. We developed JAMM (Joint Analysis of NGS replicates via Mixture Model clustering): a peak finder that can integrate information from biological replicates, determine enrichment site widths accurately and resolve neighboring narrow peaks. JAMM is a universal peak finder that is applicable to different types of datasets. We show that JAMM is among the best performing peak finders in terms of site detection accuracy and in terms of accurate determination of enrichment sites widths. In addition, JAMM's replicate integration improves peak spatial resolution, sorting and peak finding accuracy. JAMM is available for free and can run on Linux machines through the command line: [Link]

A: Which peak calling algorithm employs mixture model clustering under the hood?
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Q: Vaginal microbicides for the prevention of HIV transmission may be an important option for protecting women from infection. Incorporation of dapivirine, a lead candidate nonnucleoside reverse transcriptase inhibitor, into intravaginal rings (IVRs) for sustained mucosal delivery may increase microbicide product adherence and efficacy compared with conventional vaginal formulations. Twenty-four healthy HIV-negative women 18-35 years of age were randomly assigned (1:1:1) to dapivirine matrix IVR, dapivirine reservoir IVR, or placebo IVR. Dapivirine concentrations were measured in plasma and vaginal fluid samples collected at sequential time points over the 33-day study period (28 days of IVR use, 5 days of follow-up). Safety was assessed by pelvic/colposcopic examinations, clinical laboratory tests, and adverse events. Both IVR types were safe and well tolerated with similar adverse events observed in the placebo and dapivirine groups. Dapivirine from both IVR types was successfully distributed throughout the lower genital tract at concentrations over 4 logs greater than the EC50 against wild-type HIV-1 (LAI) in MT4 cells. Maximum concentration (Cmax) and area under the concentration-time curve (AUC) values were significantly higher with the matrix than reservoir IVR. Mean plasma concentrations of dapivirine were <2 ng/mL. These findings suggest that IVR delivery of microbicides is a viable option meriting further study.

A: Which infection can be prevented with Dapivirine?
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Q: Elite Lessons Experienced music performer is offering one-on-one drum lesson. As the winner of the Drummer Contest, the largest drummer contest in Canada, I can teach you secret techniques that only an elite group knows, but the group doesn't share them with the public. The result is instant improvement in your speed and ability to play the drum. Lessons are taught in French or English, $25 an hour. Call at 514-585-5054 if you want to know more information. Private Tutoring Professional French tutor is offering French tutoring, $15 an hour. I possess a BA in translation from Concordia University and have over 5 years' teaching experience. The course consists of conversational French, grammar, reading comprehension ,etc. Courses are given in the downtown area. For more information please call at 514-835-1834. Customized Tutoring Hello, my name is Christopher Marion. I am a graduate students at Concordia University, 21 years of age. I was born and lived in France for 17 years. I will be happy to provide customized help in French writing or speaking. The lesson's style can be whatever suits your needs. I am charging $19 an hour. I live in downtown Montreal. Feel free to contact me at 514-785-5654. Basic Lessons for Beginners Always wanted to learn the guitar? This is your chance and it only costs $14 an hour. I can teach you to play any style of music you like in a fun and relaxed way. I start from the basics, showing you how to play the songs you love, and improving your technique as we go along. If you don't already have a guitar, that's not a problem. Please call at 514-880-8872 or email totarungeo@gmail.comif interested. Thanks!.

A:
How much shall you pay for a basic guitar lesson?
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