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Buzzi was born at Westerly Hospital, Westerly, Rhode Island, the daughter of Rena Pauline and Angelo Peter Buzzi, a nationally recognized stone sculptor. She was raised in Wequetequock, Connecticut, in a rock house overlooking the ocean at Wequetequock Cove, where her father owned Buzzi Memorials, a business still operated by her older brother, Harold. Her father was born in Arzo, Switzerland, in the Italian-speaking canton of Ticino. He carved the marble eagles at Penn Station in New York, the granite Leif Erikson memorial in Providence, Rhode Island, the animals seen in relief on the American Museum of Natural History in New York City, and made thousands of tombstones.

Before graduation from college, Buzzi was already a working actress with a union card in musical and comedy revues. Her first job in show business was at 19, traveling with singer Rudy Vallee in a live musical and comedy act during her summer break from college; it allowed her to graduate with a treasured union card with Actors' Equity Association. She moved to New York City after graduation and was hired immediately for a lead role in an off-Broadway musical revue, the first of 19 in which she performed across the East Coast. In musical and comedy revues from Provincetown, Massachusetts, to the Catskills of New York, to off-Broadway, she worked alongside other young, talented performers just beginning their careers at the time, including Barbra Streisand, Joan Rivers, Dom DeLuise, Bernadette Peters and Carol Burnett. Buzzi performed in New York musical variety shows, and she made numerous television commercials, some of which won national awards including the Clio Award. Her first national recognition on television came on The Garry Moore Show in 1964, just after Carol Burnett was replaced by Dorothy Loudon on the series. Buzzi saw her first taste of national fame as "Shagundala the Silent", a bumbling magician's assistant to her comedy partner Dom DeLuise who played "Dominic the Great". Buzzi was a member of the regular repertory company on the CBS variety show The Entertainers (1964-65). In 1966-67, Buzzi appeared in Sweet Charity, with Fosse's wife, Gwen Verdon, in the original cast. She had several small roles, one of them "the Singing Fairy".
Ruth Buzzi