Q: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Viral epitranscriptomics is a newly emerging field that has identified unique roles for RNA modifications in modulating life cycles of RNA viruses. Despite the observation of a handful of modified viral RNAs five decades ago, very little was known about how these modifications regulate viral life cycles, until recently. Here we review the pro-and anti-viral effects of methyl-6-adenosine in distinct viral life cycles, the role of 2 0 O-methyl modifications in RNA stability and innate immune sensing, and functions of adenosine to inosine modifications in retroviral life cycles. With roles for over 100 modifications in RNA still unknown, this is a rapidly emerging field that is destined to suggest novel antiviral therapies. Cell Host & Microbe 21, June 14, 2017 2017 Elsevier Inc. 661 Figure 1. Adenosine Modifications and the Respective Enzymes that Facilitate These Chemical Modifications N 6 -methyladenosine and N 6 ,2-O-dimethyladenosine are reversible RNA modifications, while inosine and 2 0 -O-methyladenosine seem to be irreversible. Of the modifications listed, only 2 0 -O-methyltransferases are encoded by viral genes (WNV, West Nile virus; DV, dengue virus; H-CoV, human coronavirus), further supporting the important role for this modification in modulating viral sensing by innate immune pathways.
A:
Making the Mark: The Role of Adenosine Modifications in the Life Cycle of RNA Viruses