Tranquility, also known as Node 3, is a module of the International Space Station (ISS). ESA and the Italian Space Agency had Tranquility built by Thales Alenia Space. A ceremony on November 20, 2009 transferred ownership of the module to NASA. On February 8, 2010, NASA launched the module on the Space Shuttle's STS-130 mission.

Tranquility was built within the ESA-NASA ISS bartering system. ESA committed to build and fund both Harmony and Tranquility as well as the ATV in order to use NASA ISS facitilies, fly astronauts on the Shuttle and for other ISS services. ESA teamed up with the Italian Space Agency ASI to build both Harmony and Tranquility at Thales Alenia Space in Turin. Tranquility provides six berthing locations with power, data and commanding, thermal and environmental control, and crew access for more attached habitable volumes or for crew transportation vehicles or stowage, or an appropriate combination of all of these. One of the berthing locations is used by Cupola, which houses a Robotic Work Station inside it to assist in the assembly/maintenance of the ISS, and offers a window for Earth observations. Tranquility was launched with the Cupola attached to its port facing Common Berthing Mechanism (CBM). After mating Tranquility with the port CBM of Unity, the Cupola was transferred to the nadir facing port of Tranquility where it will stay. The module has three redundant berthing ports that were not scheduled to be used prior to the end of the Space Shuttle program, although there is a Power Data Grapple Fixture reserved for the Special Purpose Dexterous Manipulator (Dextre), which is located on the zenith berthing location. The current ISS configuration requires Tranquility to be docked to the port berthing location of Unity. As such, the three unused berthing locations of Tranquility were disabled as the node's close proximity to other segments would prohibit the port's direct use for cargo spacecraft or using the docking module PMA-3, which was relocated from Harmony to the port berthing location of Tranquility for storage. At the time, the move of PMA-3 to the port location of Tranquility was required because NASA decided to leave the Multi-Purpose Logistics Module (MPLM) Leonardo permanently attached to the ISS, which will be located at the nadir side of Unity. In 2001, NASA considered changing the design of the module. This idea for an extended or "stretched" module, was a result of the deferral/deletion of the Habitation Module. The stretched module would have held 16 racks, compared with the baseline capacity of eight racks. This modification was not funded and the plans were abandoned.

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