Input: Read this: The area's many colleges and universities make Boston an international center of higher education and medicine, and the city is considered to be a world leader in innovation. Boston's economic base also includes finance, professional and business services, biotechnology, information technology, and government activities. Households in the city claim the highest average rate of philanthropy in the United States; businesses and institutions rank amongst the top in the country for environmental sustainability and investment. The city has one of the highest costs of living in the United States, though it remains high on world livability rankings.
Question: Boston is internationally known for education and medicine because of its many what?

Output: colleges and universities

Input: Read this: Genome-wide association studies have found 27 genetic variants that are associated with an increased risk of myocardial infarction. Strongest association of MI has been found with the 9p21 genomic locus, which contains genes CDKN2A & 2B, although the single nucleotide polymorphisms that are implicated are within a non-coding region. The majority of these variants are in regions that have not been previously implicated in coronary artery disease. The following genes have an association with MI: PCSK9, SORT1, MIA3, WDR12, MRAS, PHACTR1, LPA, TCF21, MTHFDSL, ZC3HC1, CDKN2A, 2B, ABO, PDGF0, APOA5, MNF1ASM283, COL4A1, HHIPC1, SMAD3, ADAMTS7, RAS1, SMG6, SNF8, LDLR, SLC5A3, MRPS6, KCNE2.
Question: PCSK9 is found in what locus?

Output: unanswerable

Input: Read this: In 1821, after Mexico's War of Independence from Spain, Texas was part of the United Mexican States as the state of Coahuila y Tejas. A large influx of Americans soon followed, originally with the approval of Mexico's president. In 1836, the now largely "American" Texans, fought a war of independence from the central government of Mexico and established the Republic of Texas. In 1846, the Republic dissolved when Texas entered the United States of America as a state. Per the 1850 U.S. census, fewer than 16,000 Texans were of Mexican descent, and nearly all were Spanish-speaking people (both Mexicans and non-Spanish European settlers who include German Texan) who were outnumbered (six-to-one) by English-speaking settlers (both Americans and other immigrant Europeans).[citation needed]
Question: When did the Americans come to Texas?

Output: A large influx of Americans soon followed, originally with the approval of Mexico's president. In 1836

Input: Read this: The Daily Star had been launched in 1978 by Express Newspaper, and by 1981 had begun to affect sales of The Sun. Bingo was introduced as a marketing tool and a 2p drop in cover price removed the Daily Star's competitive advantage opening a new circulation battle which resulted in The Sun neutralising the threat of the new paper. The new editor of The Sun, Kelvin MacKenzie, took up his post in 1981 just after these developments, and "changed the British tabloid concept more profoundly than [Larry] Lamb did", according to Bruce Page, MacKenzie The paper became "more outrageous, opinionated and irreverent than anything ever produced in Britain".
Question: By what year had The Daily Star started impacting The Sun's sales?

Output:
1981