Instructions: Given a passage and a query based on the passage, generate an unambiguous, concise and simple answer to the query from information in the passage. Note that the answer may not be present in exact form.
Input: BUTRANS exposes users to risks of addiction, abuse, and misuse, which can lead to overdose and death. Assess patient's risk before prescribing, and monitor for these behaviors and conditions. (5.1, 10) Serious, life-threatening or fatal respiratory depression may occur. BUTRANS 5, 10, and 20 mcg/hour provide dose-proportional total buprenorphine exposures (AUC) following 7-day applications. BUTRANS single 7-day application and steady-state pharmacokinetic parameters are summarized in Table 7. Plasma buprenorphine concentrations after titration showed no further change over the 60-day period studied. BUTRANS is a rectangular or square, beige-colored system consisting of a protective liner and functional layers. 1 BUTRANS is available in five strengths: 2 BUTRANS 5 mcg/hour Transdermal System (dimensions: 45 mm by 45 mm) 3 BUTRANS 7.5 mcg/hour Transdermal System (dimensions: 58 mm by 45 mm) 2.6 Administration of BUTRANS. 1 Instruct patients to apply immediately after removal from the individually sealed pouch. Instruct patients not to use BUTRANS if the pouch seal is broken or the patch is cut, damaged, or changed in any way. See the Instructions for Use for step-by-step instructions for applying BUTRANS. Hi, it takes 3 days for the buprenorphine to build up in your system, so it is then that you should feel the mot pain relief. I'm like you, been on this for about a week and my pain levels are inconsistent. I'm okay in the morning but my pain is greater in afternoon/evenings despite being on the patch for 6 days now. Get emergency help right away if you take too much BUTRANS (overdose). 1 When you first start taking BUTRANS, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. If the level of pain increases after dose stabilization, attempt to identify the source of increased pain before increasing the BUTRANS dose. Because steady-state plasma concentrations are achieved within 72 hours, BUTRANS dosage may be adjusted every 3 days. Dose adjustments may be made in 5 mcg/hour, 7.5 mcg/hour, or 10 mcg/hour increments by using no more than two patches of the 5 mcg/hour, or 7.5 mcg/hour, or 10 mcg/hour system(s). The minimum BUTRANS titration interval is 72 hours, based on the pharmacokinetic profile and time to reach steady state levels [see Clinical Pharmacology (12.3)]. The maximum BUTRANS dose is 20 mcg/hour. Do not exceed a dose of one 20 mcg/hour BUTRANS system due to the risk of QTc interval prolongation. The QTc evaluation was performed during the third day of BUTRANS 10 mcg/hour and the fourth day of 2 x BUTRANS 20 mcg/hour when the plasma levels of buprenorphine were at steady state for the corresponding doses [see Warnings and Precautions ]. There was no clinically meaningful effect on mean QTc with a BUTRANS dose of 10 mcg/hour. No notable relationship was observed between estimated creatinine clearance rates and steady-state buprenorphine concentrations among patients during BUTRANS therapy. 13 nonclinical toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Query: how long to steady state for butrans
Output:
A steady-state plasma concentrations are achieved within 72 hours.