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Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.

Sesquiterpene lactones (SL) are plant secondary metabolites that are known for their anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties. Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3--methoxy-iso-seco-tanapartholide (-tan) isolated from Achillea falcata and salograviolide A (Sal A) isolated from Centaurea ainetensis, for their anti-tumor properties. We used the mouse epidermal JB6P+cells as a model for tumor promotion and cellular transformation. Key players that are involved in cellular transformation and tumorigenesis are the AP-1 and NF-B transcription factors; therefore, we assessed how -tan and Sal A modulate their signaling pathways in JB6P+cells.', 'The effects of -tan and Sal A on the growth of normal and neoplastic keratinocytes and on the tumor promotion-responsive JB6P+cells were determined using the MTT assay. Anchorage-independent cell growth transformation assays were used to evaluate the anti-tumor promoting properties of these SL molecules in JB6P+cells and dual luciferase reporter assays and western blot analysis were used to investigate their effects on tumor promoter-induced AP-1 and NF-B activities and protein levels of key AP-1 and NF-B target genes.', '-tan and Sal A selectively inhibited tumor promoter-induced cell growth and transformation of JB6P+cells at concentrations that do not affect JB6P+and primary keratinocytes basal cell growth. In addition, both molecules reduced basal and tumor promoter-induced NF-B transcriptional activities, differentially regulated basal and tumor promoter-induced AP-1 transcriptional activities, and modulated key players of the AP-1 and NF-B signaling pathways.
Output:
0