The mucosa is the innermost layer of the gastrointestinal tract. It surrounds the lumen of the tract, and comes into direct contact with digested food (chyme). The mucosa itself is made up of three layers:

Based on this passage, which layer of the digestive tract is in direct contact with digested food? Let's think fast. Stream of consciousness:
To answer the question, consider the following: It surrounds the lumen of the tract, and comes into direct contact with digested food (chyme). So the final answer is mucosa.