In this task, you are given an abstract of article. Your task is to generate label "True" if abstract is structured, otherwise generate "False". A structured abstract is composed of a topic sentence (or key sentence), relevant supporting sentences, and a closing (or transition) sentence. This structure is key to keeping your abstract focused on the main idea and creating a clear and concise image.

[Q]: UNLABELLED Artificially synthesized short interfering RNAs (siRNAs) are widely used in functional genomics to knock down specific target genes. One ongoing challenge is to guarantee that the siRNA does not elicit off-target effects. Initial reports suggested that siRNAs were highly sequence-specific; however, subsequent data indicates that this is not necessarily the case. It is still uncertain what level of similarity and other rules are required for an off-target effect to be observed, and scoring schemes have not been developed to look beyond simple measures such as the number of mismatches or the number of consecutive matching bases present. We created design rules for predicting the likelihood of a non-specific effect and present a web server that allows the user to check the specificity of a given siRNA in a flexible manner using a combination of methods. The server finds potential off-target matches in the corresponding RefSeq database and ranks them according to a scoring system based on experimental studies of specificity. AVAILABILITY The server is available at http://informatics-eskitis.griffith.edu.au/SpecificityServer.
[A]: False

[Q]: The T-cell receptor (TCR) consists of a TCR heterodimer, a TCR homodimer, and CD3 and CD3 heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3 binds to the plasma membrane through a basic residue-rich stretch (BRS) and proposed that dissociation from the membrane is required for phosphorylation thereof. In this report we show that BRS motifs within the cytoplasmic tail of TCR mediate association with the plasma membrane and that TCR engagement results in TCR dissociation from the membrane. This dissociation requires phosphorylation of the TCR immunoreceptor tyrosine-based activation motifs by lymphocyte cell-specificprotein tyrosine kinase (Lck) but not -chain-associated protein kinase 70 binding. Mutations of the TCR BRS motifs that disrupt this membrane association attenuate proximal and distal responses induced by TCR engagement. These mutations appear to alter the localization of TCR with respect to Lck as well as the mobility of the TCR complex. This study reveals that tyrosine phosphorylation of the TCR cytoplasmic domain regulates its association with the plasma membrane and highlights the functional importance of TCR BRS motifs.
[A]: False

[Q]: INTRODUCTION The face is the central point of the physical features; it transmits expressions and emotions, communicates feelings and allows for individual identity. Facial burns are very common and are devastating to the affected patient and results into numerous physical, emotional and psychosocial sequels. Partial thickness facial burns are very common especially among children. This study compares the effect of standard moist open technique management and a moist closed technique for partial thickness burns of the face.
PATIENTS AND METHODS Patients with partial-thickness facial burns admitted in the burn unit, Ain Shams University, Cairo, Egypt in the period from April 2009 to December 2009 were included in this study. They were divided into two groups to receive either open treatment with MEBO(®️) (n=20) or coverage with Aquacel(®️) Ag (n=20). Demographics (age, gender, ethnicity, TBSA, burn areas), length of hospital stay (LOS), rate of infections, time to total healing, frequency of dressing changes, pain, cost benefit and patient discomfort were compared between the two groups. The long-term outcome (incidence of hypertrophic scarring) was assessed for up to 6 months follow-up period.
RESULTS There were no significant differences in demographics between the two groups. In the group treated with the Aquacel(®️) Ag, the mean time for re-epithelialization was 10.5 days, while it was 12.4 days in the MEBO(®️) group (p<0.05). Frequency of changes, pain and patient discomfort were less with Aquacel(®️) Ag. Cost was of no significant difference between the two groups. Scar quality improved in the Aquacel(®️) Ag treatment group. Three and 6 months follow-up was done and long-term outcomes were recorded in both groups.
CONCLUSION Moist occlusive dressing (Aquacel(®️) Ag) significantly improves the management and healing rate of partial thickness facial burns with better long-term outcome compared to moist open dressing (MEBO(®️)).
[A]:
True