Context and question: Antibiotics are screened for any negative effects on humans or other mammals before approval for clinical use, and are usually considered safe and most are well tolerated. However, some antibiotics have been associated with a range of adverse side effects. Side-effects range from mild to very serious depending on the antibiotics used, the microbial organisms targeted, and the individual patient. Side effects may reflect the pharmacological or toxicological properties of the antibiotic or may involve hypersensitivity reactions or anaphylaxis. Safety profiles of newer drugs are often not as well established as for those that have a long history of use. Adverse effects range from fever and nausea to major allergic reactions, including photodermatitis and anaphylaxis. Common side-effects include diarrhea, resulting from disruption of the species composition in the intestinal flora, resulting, for example, in overgrowth of pathogenic bacteria, such as Clostridium difficile. Antibacterials can also affect the vaginal flora, and may lead to overgrowth of yeast species of the genus Candida in the vulvo-vaginal area. Additional side-effects can result from interaction with other drugs, such as elevated risk of tendon damage from administration of a quinolone antibiotic with a systemic corticosteroid. Some scientists have hypothesized that the indiscriminate use of antibiotics alter the host microbiota and this has been associated with chronic disease.
What are two examples of minor side effects caused by some antibiotics?
Answer: fever and nausea
Context and question: His next theatrical release in that same year was the World War II film Saving Private Ryan, about a group of U.S. soldiers led by Capt. Miller (Tom Hanks) sent to bring home a paratrooper whose three older brothers were killed in the same twenty-four hours, June 56, of the Normandy landing. The film was a huge box office success, grossing over $481 million worldwide and was the biggest film of the year at the North American box office (worldwide it made second place after Michael Bay's Armageddon). Spielberg won his second Academy Award for his direction. The film's graphic, realistic depiction of combat violence influenced later war films such as Black Hawk Down and Enemy at the Gates. The film was also the first major hit for DreamWorks, which co-produced the film with Paramount Pictures (as such, it was Spielberg's first release from the latter that was not part of the Indiana Jones series). Later, Spielberg and Tom Hanks produced a TV mini-series based on Stephen Ambrose's book Band of Brothers. The ten-part HBO mini-series follows Easy Company of the 101st Airborne Division's 506th Parachute Infantry Regiment. The series won a number of awards at the Golden Globes and the Emmys.
Which film beat 'Saving Private Ryan' worldwide?
Answer: Armageddon
Context and question: Zhejiang (helpinfo), formerly romanized as Chekiang, is an eastern coastal province of China. Zhejiang is bordered by Jiangsu province and Shanghai municipality to the north, Anhui province to the northwest, Jiangxi province to the west, and Fujian province to the south; to the east is the East China Sea, beyond which lie the Ryukyu Islands of Japan.
Which province is Zhejiang bordered by to the southeast?
Answer:
unanswerable