Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

[EX Q]: Context: Perturbation of the endoplasmic reticulum (ER) homeostasis has emerged as one of the prominent features of obesity and diabetes. This occurs when the adaptive unfolded protein response (UPR) fails to restore ER function in key metabolic tissues. We previously reported increased inflammation and impaired heat shock response (HSR) in obese human subjects that were restored by physical exercise. Here, we investigated the status of ER stress chaperone; glucose-regulated protein 78 (GRP78) and its downstream UPR pathways in human obese, and their modulation by a supervised 3-month physical exercise.', "Subcutaneous adipose tissue (SAT) and blood samples were collected from non-diabetic adult human lean (n=40) and obese (n=40, at baseline and after 3months of physical exercise). Transcriptomic profiling was used as a primary screen to identify differentially expressed genes and it was carried out on SAT samples using the UPR RT(2) Profiler PCR Array. Conventional RT-PCR, immunohistochemistry, immunofluorescence, Western blot and ELISA were used to validate the transcriptomic data. Correlation analyses with the physical, clinical and biochemical outcomes were performed using Pearson's rank correlation coefficient.", 'Levels of GRP78 and its three downstream UPR arms; activating transcription factor-6 (ATF6), inositol-requiring enzyme-1 (IRE1) and protein kinase RNA-like endoplasmic reticulum kinase (PERK) were increased in obese subjects. More interestingly, higher levels of circulating GRP78 protein were found in obese compared to lean subjects which correlated negatively with maximum oxygen uptake (VO2 Max) but positively with high-sensitivity C-reactive protein (hsCRP) and obesity indicators such as BMI, percentage body fat (PBF) and waist circumference. GRP78 increased secretion in obese was further confirmed in vitro using 3T3-L1 preadipocyte cells under ER stress. Finally, we showed that physical exercise significantly attenuated the expression and release of GRP78 with a concomitant reduction in the phosphorylation of IRE1 and eukaryotic initiation factor-2 (eIF2).
Answer: Our results suggest that physical exercise alleviates ER stress in human obese through attenuation of GRP78 signaling network.
[EX A]: Does physical exercise alleviate ER stress in obese humans through reduction in the expression and release of GRP78 chaperone?

[EX Q]: Context: The aim of this study was to evaluate how closely analysis of bone quality performed using the bone mineral density (BMD) values obtained by quantitative computerized tomography (QCT) reflected the histologic bone density.', "Eighteen patients requiring implant therapy underwent CT scanning. Their data were processed using Image Master software, and the BMD was calculated by measuring the Hounsfield units and relating those values to a phantom (Calibration Phantom, Quantitative Technologies). Each patient wore a radiographic-surgical template in which titanium cylinders were placed as a drilling guide for preparation of the implant site. The mouth regions where the titanium guides were placed (on the CT images and in the patient's mouth) corresponded to the implant sites where the BMD was measured and where tissue specimens for histomorphometric analysis retrieved. Forty specimens measuring 6 mm in length and 2 mm in diameter were obtained. Histomorphometric analysis was performed by digitizing the images, which were subsequently analyzed using the image analysis software IAS 2000. The bone volume (BV) was calculated as a percentage by dividing the area occupied by the mineralized bone over the entire microscopic field.", 'The results of the statistical analysis showed a Pearson correlation coefficient of 0.691 between the BV and BMD values, with a P value < 0.01, which was considered significant.
Answer: The results of this study support the use of QCT to assess the bone quality before implant placement to improve the planning of implant treatment.
[EX A]: Are bone mineral density and bone histomorphometry statistically related?

[EX Q]: Context: Attentional and executive dysfunctions are associated with falls in community-dwelling elderly individuals and patients with PD. Frontal cognitive dysfunction and falls are frequent symptoms of PSP. We studied to identify the cognitive domains associated with recurrent falls in patients with PSP.', 'We performed a battery of neuropsychological tests in 59 individuals with probable PSP. We categorized patients into infrequent fall (one fall during the last 12 months, n=29) or recurrent fall (two falls during the last 12 months, n=30) groups.', 'UPDRS subscores for axial deficits were significantly higher in the recurrent fall group than the infrequent fall group, but there were no significant differences in UPDRS total motor scores or subscores for bradykinesia, rigidity, and tremor. There was no difference between groups in MMSE scores. ANCOVA with adjustment for confounding factors showed that, recurrent falls were associated with abnormalities in alternating hand movement, alternating square and triangle, RCFT copying task, and ideomotor apraxia. Group difference of abnormalities in Stroop test was marginal (p=0.054). However, there were no group differences in the frequency of abnormalities in forward or backward digit span, motor impersistence, fist-edge-palm, contrast programming, go-no-go, Luria loop drawing, or Controlled Oral Word Association Tests. Recurrent falls were not associated with memory or language dysfunction.
Answer: Recurrent falls in patients with PSP were associated mainly with executive and visuospatial dysfunctions, including (1) impaired coordinated alternating uni- and bimanual motor programming and execution, (2) deficit of attention and decision making in the presence of interference, (3) visuospatial misperception and (4) ideomotor apraxia.
[EX A]:
Does cognitive dysfunction associated with fall in progressive supranuclear palsy?