instruction:
Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
question:
The release does not mention cost. The FDA evaluates drugs without consideration of cost, so it's understandable that they wouldn't comment on it and that's why we're rating this Not Applicable. But let's be real here: The value of a new drug is a function not just of how well it works, but its cost-effectiveness. So we look forward to the day when any news release about a new drug even one from the FDA will include some mention of cost in its message. This release gives the preliminary results from a single study of 310 patients. Because the drug is experimental, long-term results haven't been studied. Of the 310 patients enrolled in the lone trial upon which the approval is based, 14.8 percent showed some shrinkage of tumors during the assessment period lasting from 2.1 to about 13.8 months. For a subset of patients who were classified as having a positive response to PD-L1 expression, the response was 26 percent. As noted above, tumor shrinkage doesn't always lead to improvements in survival or quality of life. It is a surrogate endpoint a substitute for the main outcome which is survival. Although this drug looks promising, to be fully transparent about its benefits as currently known, the release should have explained this. As noted in the "Summary," another larger study is underway to assess the drug's impact on extending life and improving quality of life. The release includes a description of side effects of this treatment. The most common ones included fatigue, decreased appetite, nausea, urinary tract infection, fever (pyrexia) and constipation. The release also mentions that patients taking the drug have an increased risk of infection and serious side effects that are "immune-mediated." We would have liked a bit more context on what this term means for patients. The release outlines that this is the very first clinical trial of this compound for safety and efficacy, and under which regulatory paths the drug was assessed, including "breakthrough therapy designation, priority review status and accelerated approval." We're giving this release the benefit of the doubt and rating it Satisfactory for its bare bones description of the trial (and since we already addressed the lack of long-term survival data in the "Benefits" section.) As it stands, the results from the small trial were preliminary and short-term and did not reflect long-term survival. We would have liked to see a reference or link to the completed trial where one could look at the results to assess independently or learn more about the outcomes. We think the release should have provided more data on the patient demographics, the treatment regimen (dosing amount and schedule) as well as the range in tumor reduction. There is no disease mongering. This release describes the approval of a new drug by a regulatory agency, but we'd still like to know who sponsored the study that's the basis for the approval. It's not enough to state who markets the drug. The release does not give us very much information about alternatives. These patients had already received other therapy and their cancer had recurred, so it is implied that they had no other alternatives. But this isn't stated very clearly. We can assume (and it seems evident) that the platinum-based therapy that the patients didn't respond to initially is the usual treatment. The FDA's approval of a drug clears the way for the drug sponsor to scale up production and begin marketing and selling the product. (The FDA doesn't state this explicitly but it can be inferred.) A NYT article said the drug would be available in about two months. The release clearly states this product is first of its kind for this type of cancer. We found no unjustifiable language.
answer:
FDA approves new, targeted treatment for bladder cancer

question:
Coaches around the league are taking preventive measures to help deal with the grind and stresses of a long NBA season. That hasn't always been the case. Now, the NBA Coaches Association provides guidance to its members on everything from diet and exercise to sleep and mental health. "Well, we're trying. We all are trying, we all are conscious of it," Clippers coach Doc Rivers said. "I don't think we're very good at it, honestly. I know I've tried. It's still very hard to accomplish. The game consumes us. It consumes me at least, and it should, if you love it. And it's just hard to turn off. It's important. We have to do it. We should have been doing it." After a late arrival in Bay Area last month, it was after 10 p.m. when Rivers had the team tissue therapist work on his body, including knees and ankle "and my brain." He has consulted a sleep doctor, too. In Los Angeles, Walton is being proactive by encouraging every staff member to stay physically, mentally and emotionally healthy. The advice is to recharge when necessary, in whatever way is best. "It's a priority," Lakers assistant Mark Madsen said. "It's important because think about all the late nights. We'll get into cities at 4 in the morning sometimes. You have to stay on top of it." As a youngster, J.B. Bickerstaff knew there were a couple of hours in the afternoon on game days his father needed for himself. Bernie Bickerstaff took a power nap that allowed him to be fresh for a long night on the NBA bench. J.B. Bickerstaff now does it the same exact way as coach of the Memphis Grizzlies. The coaches' association is providing support and guidance like never before, and many coaches are making a point to openly discuss wellness strategies and share ideas. There's also a close-knit support system within this crop of NBA coaches that Dallas' Rick Carlisle, the coaches' association president, considers special. "We also have a unique group of head coaches right now, guys that are extremely competitive but have great respect for one another and provide a high level of support for each other," Carlisle said. "Guys who are going through tough times with health and even things like losing streaks. We've got a very high character group." For example, Clifford so appreciated a call he got last season from Kerr, each having gone through his own challenging health ordeal that kept him from the bench for an extensive stretch. Clifford, then coaching the Charlotte Hornets, missed more than five weeks dealing with agonizing headaches that after a battery of tests were deemed to be caused by sleep deprivation. Kerr has endured some of the most high-profile absences. He missed the initial 43 games of the 2015-16 season including a record 24-0 start dealing with painful and confounding symptoms following a pair of back surgeries. Kerr was sidelined again for 11 games during the Warriors' 16-1 postseason in 2017 before returning to the bench for Game 2 of the NBA Finals the Warriors wound up winning in five games against LeBron James and Cleveland. Kerr had undergone a procedure to repair a spinal fluid leak on May 5, 2017, at Duke University but was not well enough to return until June 4. He made it through last year's repeat run to a title. "My advice to coaches who are coming into the league: Don't get back surgery," Kerr quipped. "That's my main advice. Sorry, bad joke. Luke Walton, when he took the Laker job, we talked a lot about that. He told me his whole staff is really on a conditioning program and a health-wellness program. I think it's really smart, something that every staff should try to do is just make sure you've got people looking after you and looking after each other." Kerr practices regular yoga and can often be seen on the elliptical machine after practice in a corner of the gym, getting loose on a foam roller or stretching with the assistance of an athletic trainer. Trail Blazers coach Terry Stotts appreciates the points of emphasis and information provided by the coaches' association "whether it's diet or things to alleviate stress." He watches what he eats and works in exercise whenever he can, saying those two things are "the remedy for everybody." "A lot of it is just common sense that everybody has to deal with to take care of yourself," Stotts said. "It's not just coaches, obviously, it's everybody, a lot of middle-aged men need to be doing the same, and some like me, beyond-middle-aged men. The fact that our lifestyle, if you give in to it, it can be a detriment, and everybody needs to be aware of it." Clifford is in Orlando now, and he understands better than ever the importance of taking care of himself and monitoring his own health in a business where keeping your job depends largely on winning. He took significant steps to improve his sleep patterns and overall health, this after a previous heart scare as well. The 57-year-old Clifford deeply appreciated Kerr's call. "It was great," Clifford said. "He was one of the guys who reached out and obviously we had the health issue in common. It was a terrific gesture." Last season, former Cavaliers coach Tyronn Lue dealt with anxiety and needed a mental and physical break. "Wellness isn't just physical. It's mental as well," Portland guard Damian Lillard said. "I think the position we're in as professional athletes and with coaches in the social media age, it's a little more difficult. That takes it to a much higher level from physical and mental ... when you've got people talking about you all the time, on Twitter bashing you. People just have so much more access to you. It becomes a more stressful job, much more pressure on your job and so many more eyes." Coaches are also realizing they can't always do it alone, relying on experts to stay healthy. Golden State hired Rick Celebrini this past offseason as director of sports medicine and performance. "If you can find some help, somebody to give you a little guidance," Kerr said, "like we have here with Rick and Drew Yoder, I think it's a big help." The coaches' association sends a regular newsletter with guidance from nutrition consultant Stacy Goldberg, who also is always available for 1-on-1 conversations. She attends coach association meetings, too, offering healthy food and snack choices. "Often, coaches are so focused on taking care of the players that they are not always focused on taking care of themselves," said Goldberg, founder and CEO of Savorfull. "This is especially true when it comes to their nutrition." Added Carlisle: "We view this as important as anything else we do with the NBA coaches association." ___ More AP NBA: https://apnews.com/tag/NBA and https://twitter.com/AP_Sports
answer:
NBA coaches' new play: tending to health to cope with grind.

question:
Five people were hurt during the attack Friday at the Arndale Centre in Manchester. Thee of the injured needed hospital treatment but none of the injuries are believed to be life-threatening. Police arrested the 41-year-old man on a charge of "the commission, preparation and instigation of an act of terrorism." The incident revived uncomfortable memories of another attack in 2017 only a few hundred meters away. A suicide bomber killed 22 people after targeting a concert by pop star Ariana Grande at Manchester Arena,
answer:
Knife suspect detained under UK's Mental Health Act.