TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does apelin-13 protect the heart against ischemia-reperfusion injury through the RISK-GSK-3-mPTP pathway?
Answer: The protective mechanism of apelin-13 might be that inactivation of GSK-3 could inhibit the opening of mPTP by activating PI3K/Akt and ERK1/2 involved in the reperfusion injury salvage kinase (RISK) pathway.

SOLUTION: yes

PROBLEM: Question: Does protamine affect the formation of cGMP or cAMP in pig vascular smooth muscle cells in response to vasodilators?
Answer: These experiments show that protamine does not alter the responses of the intracellular second messengers, cGMP and cAMP, to the vasodilators sodium nitroprusside, atrial natriuretic peptide, isoproterenol, and forskolin. These results do not support the hypothesis that protamine sensitizes vascular smooth muscle cells to the endothelium-derived relaxing factor, nitric oxide.

SOLUTION: no

PROBLEM: Question: Does leucocyte-depleting arterial line filtration reduce myocardial injury assessed by Troponin T during routine coronary artery bypass grafting using crossclamp fibrillation?
Answer: LD arterial line filters did not confer any cardioprotective effect as measured by Troponin T in elective coronary revascularization cases.

SOLUTION:
no