Detailed Instructions: In this task, you need to Translate Czech text to English.
Problem:Deriv ty 5-substituovanch pyrrolo[3,4-d]pyrimidin-2,4-dion obecn ho vzorce I, kde substituenty maj specifick vznam, zp sob jejich p pravy, farmaceutick prostedky, kter je obsahuj a pou it t chto deriv t pro l bu nebo prevenci revmatoidn artritidy nebo rezistence k transplantovanm org n m nebo tk n m.Solution:
In the present invention there are disclosed derivatives of 5-substituted pyrrolo[3,4-d]pyrimidine-2,4-diones of the general formula I, in which the substituents have specific meaning, further process of their preparation, pharmaceuticals in which the derivatives are comprised as well as the use of these derivatives for treating or prevention of rheumatic arthritis or resistance to transplanted organs or tissues.