William Dampier was born at Hymerford House in East Coker, Somerset, in 1651. He was baptised on 5 September, but his precise date of birth is not recorded. He was educated at King's School, Bruton. Dampier sailed on two merchant voyages to Newfoundland and Java before joining the Royal Navy in 1673.

The War of the Spanish Succession had broken out in 1701, and English privateers were being readied to act against French and Spanish interests. Dampier was appointed commander of the 26-gun ship St George, with a crew of 120 men. They were joined by the 16-gun Cinque Ports with 63 men, and sailed on 11 September 1703 from Kinsale, Ireland. The two ships made a storm-tossed passage round Cape Horn, arriving at the Juan Fernandez Islands off the coast of Chile in February 1704. While watering and provisioning there, they sighted a heavily armed French merchantman, which they engaged in a seven-hour battle but were driven off. Dampier succeeded in capturing a number of small Spanish ships along the coast of Peru, but released them after removing only a fraction of their cargoes because he believed they "would be a hindrance to his greater designs." The greater design he had in mind was a raid on Santa Maria, a town on the Gulf of Panama rumoured to hold stockpiles of gold from nearby mines. When the force of seamen he led against the town met with unexpectedly strong resistance, however, he withdrew. In May 1704, Cinque Ports separated from St George and, after putting Alexander Selkirk ashore alone on an island for complaining about the vessel's seaworthiness, sank off the coast of what is today Colombia. Some of its crew survived being shipwrecked but were made prisoners of the Spanish. It was now left to St George to make an attempt on the Manila galleon, the main object of the expedition. The ship was sighted on 6 December 1704, probably Nuestra Senora del Rosario. It was caught unprepared and had not run out its guns. But while Dampier and his officers argued over the best way to mount an attack, the galleon got its guns loaded and the battle was joined. St George soon found itself out-sized by the galleon's 18- and 24-pounders, and, suffering serious damage, they were forced to break off the attack. The failure to capture the Spanish galleon completed the break-up of the expedition. Dampier, with about thirty men, stayed in St George, while the rest of the crew took a captured barque across the Pacific to Amboyna in the Dutch settlements. The undermanned and worm-damaged St George had to be abandoned on the coast of Peru. He and his remaining men embarked in a Spanish prize for the East Indies, where they were thrown into prison as pirates by their supposed allies the Dutch but later released. Now without a ship, Dampier made his way back to England at the end of 1707.

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