Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Iron deficiency is the most common nutritional disorder affecting at least one third of world's population. Though anemia is common manifestation of iron deficiency, other effects of iron deficiency on various tissues, organs and systems are usually under recognized. Impaired brain development and cognitive, behavioural and psychomotor impairment are most worrisome manifestations of iron deficiency. Studies have demonstrated that some of these changes occurring during period of brain growth spurt (<2 years age) may be irreversible. Association of iron deficiency with febrile seizures, pica, breath holding spells, restless leg syndrome and thrombosis is increasingly being recognized. Impaired cell-mediated immunity and bactericidal function are generally noted in iron-deficient persons; however, the findings are inconsistent. Despite proven reversible functional immunological defects in vitro studies, a clinically important relationship between states of iron deficiency and susceptibility to infections remains controversial. Studies from malaria endemic regions have reported increased incidence of malaria in association with iron supplementation. These and some other aspects of iron deficiency are reviewed in this article.

Answer: Which deficiency is the cause of restless leg syndrome?

Question: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients.

Answer: Which gene is involved in CADASIL?

Question: OUR KIDS ARE AMAZING-especially compared with everybody else's (who seem to cry all the time). How do you show your love for your kids this holiday season? With toys that are smooth and colorful, interactive and exciting. And with ones that have educational value-because you are the boss. 1. FLAX ART HOSPITAL PUZZLE AND PLAY SET Here is a toy that doesn't need power-and the bike have to put it together themselves. This 50 piece puzzle set is made of soft edged hardwood and makes a complete hospital, with an X ray room. It also includes eight patients, a car and a driver. $135; flaxart.com. 2. TINY LOVE ACTIVITY BALL Sure, it's cool, but this colorful baby toy also develops problem solving and motor skills. It has a head and legs, a magnetic hand and a tail. Suitable for little ones from 6 to 36 months. $19.95; tinylove.com. 3. ROBOSAPIEN This small, remote control robot is really powerful. It performs 67 preprogrammed functions , including throwing, kicking, picking up and dancing. You can even program your own function which, sadly, does not include doing windows. $99; robosapienonline.com. 4. MINI PEDAL CAR Want a Mini Cooper but can't fit the family inside? Get one for the kids. They can jump into this Mini car, which comes in hot orange with a single adjustable seat, and ride away. But it could spoil them for that used car they'll be driving when they turn 16.For ages 3 to 5.$189; minus A. com (click on "gear up," then "Mini motoring gear").

Answer:
Which toy is said to have the special design for children's safety?