IN: Although people typically use the word ''antihistamine'' to describe drugs for treating allergies, doctors and scientists use the term to describe a class of drug that opposes the activity of histamine receptors in the body. In this sense of the word, antihistamines are subclassified according to the histamine receptor that they act upon. The two largest classes of antihistamines are H-antihistamines and H-antihistamines. Antihistamines that target the histamine H-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing) as well as for insomnia. They are sometimes also used to treat motion sickness or vertigo caused by problems with the inner ear. Antihistamines that target the histamine H-receptor are used to treat gastric acid conditions (e.g., peptic ulcers and acid reflux). H-antihistamines work by binding to histamine H receptors in mast cells, smooth muscle, and endothelium in the body as well as in the tuberomammillary nucleus in the brain; H-antihistamines bind to histamine H receptors in the upper gastrointestinal tract, primarily in the stomach.
is histamine an agonist for h1 and h2 receptors?

OUT: yes

IN: Fifty Shades Freed is an upcoming American psychological erotic romantic thriller film directed by James Foley and written by Niall Leonard, based on the novel of same name by E.L. James. It is the final film in the Fifty Shades trilogy, and a sequel to Fifty Shades of Grey (2015) and Fifty Shades Darker (2017). The film stars Dakota Johnson and Jamie Dornan as Anastasia Steele and Christian Grey, respectively.
will there be a sequel to fifty shades darker?

OUT: yes

IN: The United States men's national soccer team has played in several World Cup finals, with their best result occurring during their first appearance at the 1930 World Cup, when the United States finished in third place. After the 1950 World Cup, in which the United States upset England in group play 1--0, the U.S. was absent from the finals until 1990. The United States has participated in every World Cup since 1990 until they failed to qualify for the 2018 competition after a loss to Trinidad and Tobago in 2017.
has usa ever won the fifa world cup?

OUT: no

IN: Boiling water is not recommended for use in hot-water bottles. This is due to risks of the rubber being degraded from high-temperature water, and the risk of injury in case of breakage.
do u put boiling water in a hot water bottle?

OUT:
no