TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Mirza Tahir Hussain (born 1 June 1970) is a British man paroled on 17 November 2006 after spending 18 years on death row in Pakistan for the murder of a taxicab driver named Jamshed Khan in 1988, a crime which he says he committed in self-defence, as Khan pulled out a gun and tried to sexually assault him.

SOLUTION: Which crime Mirza Tahir Hussain is considered to have commited?

PROBLEM: Ataxin-3 (AT3) is the protein that triggers the inherited neurodegenerative disorder spinocerebellar ataxia type 3 when its polyglutamine (polyQ) stretch close to the C-terminus exceeds a critical length. AT3 consists of the N-terminal globular Josephin domain (JD) and the C-terminal disordered one. It cleaves isopeptide bonds between ubiquitin monomers, an event involved in protein quality control mechanisms. AT3 has been implicated in the pathway that sorts aggregated protein to aggresomes via microtubules, in which dynein and histone deacetylase 6 (HDAC6) also seem to be involved. By taking advantage of small angle X-ray scattering (SAXS) and surface plasmon resonance (SPR), we have investigated the interaction of AT3 with tubulin and HDAC6. Based on SAXS results, the AT3 oligomer, consisting of 6-7 subunits, tightly binds to the tubulin hexameric oligomer in a "parallel" fashion. By SPR analysis we have demonstrated that AT3 binds to tubulin dimer with a 50nM affinity. Binding fits with a Langmuir 1:1 model and involves a single binding interface. Nevertheless, the interaction surface consists of three distinct, discontinuous tubulin-binding regions (TBR), one located in the JD, and the two others in the disordered domain, upstream and downstream of the polyQ stretch. In the absence of any of the three TBRs, the affinity is drastically reduced. By SPR we have also provided the first evidence of direct binding of AT3 to HDAC6, with affinity in the range 0.1-1M. These results shed light on the interactions among the components of the transport machinery that sorts aggregate protein to the aggresome, and pave the way to in vivo studies aimed at further clarifying their roles.

SOLUTION: Which is the protein implicated in Spinocerebellar ataxia type 3?

PROBLEM: The movie begins in the year 1967 with a pregnant woman being admitted to a hospital, bleeding from the neck. Paramedics think she was attacked by some type of animal. Doctors perform an emergency C-Section, and her baby (a boy) is born alive just as she dies.Thirty years later a young man named Dennis (Kenny Johnson) is riding in a car with an attractive redhead named Racquel (Traci Lords) heading to an underground nightclub (located, oddly, in a slaughterhouse) somewhere in Los Angeles. After addressing the doorman in Russian, Racquel brings the young man into the club. The man is confused and trying to understand the rules of the club. Some of the regulars indifferently push him aside. Saying he needs a drink, the sprinkler suddenly system activates, raining blood down on everyone inside. It is then that he (and the audience) realizes that everyone in the club is a vampire.Dennis desperately tries to get away and winds up at the feet of a menacing figure in a black-leather trenchcoat. The vampires look on this figure with awe, mumbling the words: "it's the Daywalker!" This is our first look at Blade (Wesley Snipes), the vampire killer.Blade pulls out a shotgun and opens fire on the vampires, who instantly burn to ashes when killed. When the gun is knocked out of his hands by Racquel, Blade uses a set of silver stakes to kill Racquel and more vampires, including the disk jockey. Soon all the vamps are either dead or have fled except for one; a heavyset vamp named Quinn (Donal Logue), whom Blade has apparently run into before. Blade pins Quinn to the wall, and then sets him on fire before confronting the last member in the club (the human man from the beginning). Finding no vampire bite marks on Dennis, Blade lets him live and makes his escape as the police arrive.Quinn is extinguished and taken to the local hospital. A morgue technician examines his blood and shows the results to Dr. Karen Jenson (N'Bushe Wright), who finds a number of irregularities, including abnormally developed jaw muscles. As they are discussing the test results, Quinn springs back to life and bites both doctors. Before he can finish Dr. Jenson, Blade shows up and saves her, cutting off one of Quinn's arms.Blade brings Karen to his hideout and asks for help from his mentor, an elderly man named named Whistler (Kris Kristofferson). Whistler injects Dr. Jenson with a solution of garlic essence and silver nitrate and remarks that she has a 50/50 chance of recovering.Meanwhile, a group of vampires are discussing Blade's latest attack on their members. Apparently this club (and to an extent, Quinn) is the property of a vampire named Deacon Frost (Stephen Dorff). Frost wants the vampires to outright rule the humans and use them as a food source while the others (particularly an older vampire named Dragonetti) prefer to maintain a peaceful co-existance. Dragonetti (Udo Kier) in particular does not like Frost because Frost is not a "pure-blood" (ie: was not born a vampire, merely became one through the bite of another). Frost is also arrogant and his & the actions of his followers draw unnecessary attention to the vampire underworld.The next morning, Jenson awakens and sees Whistler injecting Blade with some type of serum. She tries to run away but Whistler confronts her and tells her that he and Blade are hunting vampires. Karen of course is skeptical, but Whistler goes on to talk about what they use to hunt- explaining that vampires are severely allergic to silver & garlic while also being vulnerable to sunlight (ultraviolet rays in particular). Whistler fuels up Blade's car and gives him a new UV flashlight to use when hunting that night. Whistler also gives Karen a type of "vampire mace" (garlic & silver nitrate in a liquid form).Blade drops Karen off at her apartment and she tries to pack up and get out of town. A police officer, identifying himself as Officer Krieger (Kevin Patrick Walls), arrives and questions her about the events

SOLUTION:
What are the weapons made out of?