In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Ex Input:
Paragraph: Coronaviruses infect a variety of mammalian and avian species and cause serious diseases in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS), feline infectious peritonitis (FIP), mouse hepatitis, and avian infectious bronchitis, respectively. No effective vaccine or treatment has been developed for SARScoronavirus or FIP virus, both of which cause lethal diseases. It has been reported that a cyclophilin inhibitor, cyclosporin A (CsA), could inhibit the replication of coronaviruses. CsA is a well-known immunosuppressive drug that binds to cellular cyclophilins to inhibit calcineurin, a calcium-calmodulin-activated serine/threonine-specific phosphatase. The inhibition of calcineurin blocks the translocation of nuclear factor of activated T cells from the cytosol into the nucleus, thus preventing the transcription of genes encoding cytokines such as interleukin-2. Cyclophilins are peptidyl-prolyl isomerases with physiological functions that have been described for many years to include chaperone and foldase activities. Also, many viruses require cyclophilins for replication; these include human immunodeficiency virus, vesicular stomatitis virus, and hepatitis C virus. However, the molecular mechanisms leading to the suppression of viral replication differ for different viruses. This review describes the suppressive effects of CsA on coronavirus replication.
Title: Suppression of Coronavirus Replication by Cyclophilin Inhibitors

Ex Output:
True

Ex Input:
Paragraph: Basic and translational research on lung biology has discovered multiple progenitor cell types, specialized or facultative, responsible for turnover, renewal, and repair. Isolation of populations of resident lung progenitor cells (LPCs) has been described by multiple protocols, and some have been successfully applied to healthy human lung tissue. We aimed at understanding how different cell culture conditions may affect, in vitro, the phenotype of LPCs to create an ideal niche-like microenvironment. The influence of different substrates (i.e., fibronectin, gelatin, laminin) and the impact of a three-dimensional/two-dimensional (3D/2D) culture switch on the biology of LPCs isolated as lung spheroids (LSs) from normal adult human lung biopsy specimens were investigated. We applied a spheroid culture system as the selective/inductive step for progenitor cell culture, as described in many biological systems. The data showed a niche-like proepithelial microenvironment inside the LS, highly sensitive to the 3D culture system and significantly affecting the phenotype of adult LPCs more than culture substrate. LSs favor epithelial phenotypes and LPC maintenance and contain cells more responsive to specific commitment stimuli than 2D monolayer cultures, while secreting a distinctive set of paracrine factors. We have shown for the first time, to our knowledge, how culture as 3D LSs can affect LPC epithelial phenotype and produce strong paracrine signals with a distinctive secretomic profile compared with 2D monolayer conditions. These findings suggest novel approaches to maintain ex vivo LPCs for basic and translational studies. STEM CELLS TRANSLATIONAL MEDICINE 2016;5:1-11 SIGNIFICANCE A lung niche-like microenvironment was created ex vivo inside the pneumosphere. Pneumospheres have a distinctive secretomic profile compared with two-dimensional culture. Three-dimensional culture switch significantly affects lung progenitor phenotype. Lung progenitors in pneumospheres were more committed toward epithelial lineages.
Title: Tissue-Specific Progenitor and Stem Cells Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells With Distinctive Paracrine and Plasticity Properties

Ex Output:
True

Ex Input:
Paragraph: RSV, PIVs, and HMPV are members of the Paramyxoviridae family. The epidemiology, clinical manifestations, and treatment of each of these viruses are discussed separately. RSV has two subtypes, A and B, with the former typically causing more severe disease. While both subtypes can simultaneously circulate during outbreaks, a few distinct genotypes of each subtype can predominate within a community. The dominant strains can also shift yearly. This shifting of viral strains, along with the waning protective immunity from natural infection, might account for frequent re-infections throughout life [38] . RSV usually causes mild and self-limited URTI in healthy older children and nonelderly adults, but certain patient populations are at risk for developing severe RSV infection, including premature or very young infants, elderly patients with comorbidities, or immunocompromised hosts [39] [40] [41] . RSV has been associated with apnea in young or preterm infants [42] and can cause severe LRTI in children including bronchiolitis, pneumonia, and acute respiratory failure [42] . Among adults infected with RSV, more than 80% are symptomatic, and lower respiratory tract signs and symptoms can occur in a quarter of the patients [43] . Signs of URTI include cough, rhinorrhea, and conjunctivitis, and compared to influenza, RSV is more frequently associated with nasal congestion, ear and sinus involvement, productive cough, and longer duration of illness [43] .
Title: Respiratory Viral Infections in Transplant Recipients

Ex Output:
True