instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole. This provided an opportunity for dissecting centriole assembly and characterizing assembly intermediates. Critical components were identified and ordered into an assembly pathway through siRNA and localized through immunoelectron microscopy. Plk4, hSas-6, CPAP, Cep135, gamma-tubulin, and CP110 were required at different stages of procentriole formation and in association with different centriolar structures. Remarkably, hSas-6 associated only transiently with nascent procentrioles, whereas Cep135 and CPAP formed a core structure within the proximal lumen of both parental and nascent centrioles. Finally, CP110 was recruited early and then associated with the growing distal tips, indicating that centrioles elongate through insertion of alpha-/beta-tubulin underneath a CP110 cap. Collectively, these data afford a comprehensive view of the assembly pathway underlying centriole biogenesis in human cells.
Question: Where in the cell do we find the protein Cep135?
answer:
centrosome

question:
Context: Ehlers-Danlos syndrome is a complex hereditary connective tissue disorder that is characterized by abnormalities of the skin and joints and visceral and neurological manifestations. At present, at least 11 forms are recognized on the basis of their clinical characteristics, methods of transmission, and biochemical defect. The neurologic manifestations include cerebrovascular disease, peripheral neuropathy, plexopathy, periventricular subependymal heterotopias, and epilepsy. Previously, 2 females were reported to be affected with subependimal periventricular heterotopias and Ehlers-Danlos syndrome type 1. The authors report a new case of a 12-year-old girl with similar clinical and neuroradiological features.
Question: What tissue is most affected in Ehlers-Danlos syndromes?
answer:
connective tissue

question:
Context: Weathering is the process that changes solid rock into sediments. Sediments were described in the chapter "Ma- terials of Earths Crust." With weathering, rock is disintegrated. It breaks into pieces. Once these sediments are separated from the rocks, erosion is the process that moves the sediments. While plate tectonics forces work to build huge mountains and other landscapes, the forces of weathering gradually wear those rocks and landscapes away. Together with erosion, tall mountains turn into hills and even plains. The Appalachian Mountains along the east coast of North America were once as tall as the Himalayas. No human being can watch for millions of years as mountains are built, nor can anyone watch as those same mountains gradually are worn away. But imagine a new sidewalk or road. The new road is smooth and even. Over hundreds of years, it will completely disappear, but what happens over one year? What changes would you see? (Figure 1.1). What forces of weathering wear down that road, or rocks or mountains over time? A once smooth road surface has cracks and fractures, plus a large pothole. Click image to the left or use the URL below. URL:
Question: if a river in flood picks up a house and moves it downstream, this is
answer:
erosion