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Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.

When was penicillin G first purified?
Answer: 1942

Problem: The Three Gorges Dam, the largest dam ever constructed, is being built on the Yangtze River in nearby Hubei province to control flooding in the Sichuan Basin, neighboring Yunnan province, and downstream. The plan is hailed by some as China's efforts to shift towards alternative energy sources and to further develop its industrial and commercial bases, but others have criticised it for its potentially harmful effects, such as massive resettlement of residents in the reservoir areas, loss of archeological sites, and ecological damages.
What is the purpose of the Three Gorges Dam?
The answer is the following: to control flooding in the Sichuan Basin, neighboring Yunnan province, and downstream

Montana has a larger Native American population numerically and percentage-wise than most U.S. states. Although the state ranked 45th in population (according to the 2010 U.S. Census), it ranked 19th in total native people population. Native people constituted 6.5 percent of the state's total population, the sixth highest percentage of all 50 states. Montana has three counties in which Native Americans are a majority: Big Horn, Glacier, and Roosevelt. Other counties with large Native American populations include Blaine, Cascade, Hill, Missoula, and Yellowstone counties. The state's Native American population grew by 27.9 percent between 1980 and 1990 (at a time when Montana's entire population rose just 1.6 percent), and by 18.5 percent between 2000 and 2010. As of 2009, almost two-thirds of Native Americans in the state live in urban areas. Of Montana's 20 largest cities, Polson (15.7 percent), Havre (13.0 percent), Great Falls (5.0 percent), Billings (4.4 percent), and Anaconda (3.1 percent) had the greatest percentage of Native American residents in 2010. Billings (4,619), Great Falls (2,942), Missoula (1,838), Havre (1,210), and Polson (706) have the most Native Americans living there. The state's seven reservations include more than twelve distinct Native American ethnolinguistic groups.
Between what years did the Native population increase by 27.9%
1980 and 1990

Input: Sino-Tibetan relations during the Ming dynasty
Tsai writes that shortly after the visit by Deshin Shekpa, the Yongle Emperor ordered the construction of a road and of trading posts in the upper reaches of the Yangzi and Mekong Rivers in order to facilitate trade with Tibet in tea, horses, and salt. The trade route passed through Sichuan and crossed Shangri-La County in Yunnan. Wang and Nyima assert that this "tribute-related trade" of the Ming exchanging Chinese tea for Tibetan horseswhile granting Tibetan envoys and Tibetan merchants explicit permission to trade with Han Chinese merchants"furthered the rule of the Ming dynasty court over Tibet". Rossabi and Sperling note that this trade in Tibetan horses for Chinese tea existed long before the Ming. Peter C. Perdue says that Wang Anshi (10211086), realizing that China could not produce enough militarily capable steeds, had also aimed to obtain horses from Inner Asia in exchange for Chinese tea. The Chinese needed horses not only for cavalry but also as draft animals for the army's supply wagons. The Tibetans required Chinese tea not only as a common beverage but also as a religious ceremonial supplement. The Ming government imposed a monopoly on tea production and attempted to regulate this trade with state-supervised markets, but these collapsed in 1449 due to military failures and internal ecological and commercial pressures on the tea-producing regions.

where did the trade route pass through?
Output: through Sichuan and crossed Shangri-La County in Yunnan

Input: Article: From the years 1500 to 1850, an estimated 3.5 million captives were forcibly shipped from West/Central Africa to Brazil; the territory received the highest number of slaves of any country in the Americas. Scholars estimate that more than half of the Brazilian population is at least in part descended from these individuals. Brazil has the largest population of Afro-descendants outside of Africa. In contrast to the US, during the slavery period and after, the Portuguese colonial government and later Brazilian government did not pass formal anti-miscegenation or segregation laws. As in other Latin countries, intermarriage was prevalent during the colonial period and continued afterward. In addition, people of mixed race (pardo) often tended to marry white, and their descendants became accepted as white. As a result, some of the European descended population also has West African or Amerindian blood. According to the last census of the 20th century, in which Brazilians could choose from five color/ethnic categories with which they identified, 54% of individuals identified as white, 6.2% identified as black, and 39.5% identified as pardo (brown) a broad multi-racial category, including tri-racial persons.

Now answer this question: How many slaves were shipped from Africa to Brazil between 1500 and 1850?

Output: estimated 3.5 million

Problem: The Maratha states, following the Anglo-Maratha wars, eventually lost to the British East India Company in 1818 with the Third Anglo-Maratha War. The rule lasted until 1858, when, after the Indian rebellion of 1857 and consequent of the Government of India Act 1858, the British government assumed the task of directly administering India in the new British Raj. In 1819 Stamford Raffles established Singapore as a key trading post for Britain in their rivalry with the Dutch. However, their rivalry cooled in 1824 when an Anglo-Dutch treaty demarcated their respective interests in Southeast Asia. From the 1850s onwards, the pace of colonization shifted to a significantly higher gear.
What caused the British east Indian Company rule to end?
The answer is the following:
the Indian rebellion of 1857 and consequent of the Government of India Act 1858