In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[Q]: Question: The denaturation of proteins:
Options: <1> It is accompanied by the loss of their activity. <2> It supposes the rupture of peptide bonds. <3> It is always an irreversible process. <4> Alter its primary structure. <5> It is carried out by chaperone proteins.
[A]: 1

[Q]: Question: The reordering of Cope is a reordering:
Options: <1> From an allyl vinyl ether. <2> [1,3] -sigmatropic. <3> [1,2] -sigmatropic. <4> [3,3] -sigmatropic. <5> It is a cycloaddition [4 + 2].
[A]: 4

[Q]: Question: An essential aspect that should be included in the assessment of a smoker is:
Options: <1> Degree of dependency. <2> Stage of the change process. <3> Degree of motivation <4> Supports and difficulties. <5> All are correct.
[A]:
5