In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Ex Input:
Paragraph: CD13/Aminopeptidase N (CD13) is known to play an important role in tumour cell invasion. We examined whether basic fibroblast growth factor (bFGF) is involved in the regulation of CD13 expression in human melanoma cells. 1F6 human melanoma cells were stably transfected with constructs encoding either the 18 kDa (18kD) or all (ALL) bFGF isoform proteins. We observed highly increased CD13 mRNA and protein expression in the 1F6 clones regardless of the overexpression of either the 18kD or all isoform proteins. Neutral aminopeptidase activity was increased five-fold and could be inhibited by bestatin and the CD13-neutralising antibody WM15. The enhanced invasion through Matrigel, but not migration in a wound assay, was efficiently abrogated by both bestatin and WM15. Upregulation of CD13 expression was the result of increased epithelial and myeloid promoter activity up to 4.5fold in 1F6-18kD and 1F6-ALL clones. Interestingly, in a panel of human melanoma cell lines, a significant correlation (r 2 0.883, Po0.05) between bFGF and CD13 mRNA and protein expression was detected. High bFGF and CD13 expression were clearly related with an aggressive phenotype. Taken together, our data indicate that high bFGF expression upregulates CD13 expression in human melanoma cells by activating both the myeloid and the epithelial CD13 promoter. In addition, we show that high bFGF and CD13 expression results in enhanced invasive capacity and metastatic behaviour of human melanoma cells.
Title: CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells

Ex Output:
False

Ex Input:
Paragraph: We report on the development of an on-chip RPA (recombinase polymerase amplification) with simultaneous multiplex isothermal amplification and detection on a solid surface. The isothermal RPA was applied to amplify specific target sequences from the pathogens Neisseria gonorrhoeae, Salmonella enterica and methicillin-resistant Staphylococcus aureus (MRSA) using genomic DNA. Additionally, a positive plasmid control was established as an internal control. The four targets were amplified simultaneously in a quadruplex reaction. The amplicon is labeled during on-chip RPA by reverse oligonucleotide primers coupled to a fluorophore. Both amplification and spatially resolved signal generation take place on immobilized forward primers bount to expoxysilanized glass surfaces in a pump-driven hybridization chamber. The combination of microarray technology and sensitive isothermal nucleic acid amplification at 38C allows for a multiparameter analysis on a rather small area. The on-chip RPA was characterized in terms of reaction time, sensitivity and inhibitory conditions. A successful enzymatic reaction is completed in <20 min and results in detection limits of 10 colony-forming units for methicillin-resistant Staphylococcus aureus and Salmonella enterica and 100 colony-forming units for Neisseria gonorrhoeae. The results show this method to be useful with respect to point-of-care testing and to enable simplified and miniaturized nucleic acid-based diagnostics.
Title: Multiplex isothermal solid-phase recombinase polymerase amplification for the specific and fast DNA-based detection of three bacterial pathogens

Ex Output:
True

Ex Input:
Paragraph: Transmissible gastroenteritis virus was administered orally to cats. No clinical disease resulted but infectious virus was isolated from faeces for up to 22 days after infection and serum antibody was detected by neutralisation and immunofluorescence tests. . The spread of transmissible gastroenteritis virus (TGEV) from infected pig herds and the recrudescence of infection after long periods have not been adequately explained. Experiments on the host range of the virus have indicated that nonporcine hosts could have a role in the epidemiology of TGE (2, 4, 7, 8, 9, t6). Indirect immunofluorescence (IIF) and virus neutralisation (V1N!) tests have been used recently to demonstrate antibody to TGEV in cats. In Holland and Great Britain samples from cats with clinical feline infectious peritonitis (FIP) frequently have antibody to TGEV in the I I F test (10). However, neutralising antibody has not been found in sera from Dutch cats with FIP. American and Dutch studies have recently demonstrated that sera from cats experimentally infected with F I P will cross-react, at low titre, with TGEV-infected pig cells by immunofluoreseence but will not neutralise TGEV in vitro (10, 12) . This evidence has been used to suggest that an antigenic relationship exists between TGEV and F I P virus. The potential of the cat to excrete TGEV was studied by virus reisolation and the serological responses to TGEV and F I P were monitored; thus the possible epidemiological role of the cat in TGE could be assessed. In addition information was obtained on the possible origin and relationship of VN and I I F antibodies to TGEV which occur naturally in cats, often at high titres (10, 13). TGEV strain KN63, used as inoculum in this experiment, was prepared as a clarified 50 per cent suspension of small intestine from an infected gnotobiotic piglet. I t had a titre of i.7 107 PFU/ml.
Title: Archives of Virology Virus Isolation and Serum, Antibody Responses After Infection of Cats With Transmissible Gastroenteritis Virus BrieiReport

Ex Output:
False