Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Q: FAAH degrades endocannabinoids and fatty acid amides. FAAH inhibition reduces micturition frequency and counteracts bladder overactivity in rats. We studied the effects of the peripherally active selective FAAH inhibitor URB937, and the CB1 and CB2 receptor antagonists rimonabant and SR144528, respectively, on single unit afferent activity of primary bladder afferents in rats.', 'Female Sprague Dawley®️ rats were anesthetized. Single unit afferent activity of A or C-fibers from the L6 dorsal roots was recorded during bladder filling before and after URB937 administration with or without rimonabant or SR144528. Drugs (1 mg/kg) were given intravenously. FAAH, CB1 and CB2 expression, and expression of the sensory marker CGRP inthe L6 dorsal root ganglion were compared by immunofluorescence.', 'A total of 102 single afferent fibers (48 A and 54 C-fibers) were isolated from 57 rats. URB937 decreased single unit afferent activity of C-fibers to a mean SEM of 78% 9% and of A-fibers to a mean of 67% 7% while increasing bladder compliance to a mean of 116% 3%. The effects of URB937 on single unit afferent activity and bladder compliance were counteracted by rimonabant or SR144528. Rimonabant increased single unit afferent activity ofeach fiber type but SR144528 affected only A-fiber activity. CGRP positive L6dorsal root ganglion neurons showed strong FAAH, CB1 and CB2 staining.
A:
Does inhibition of peripheral FAAH depress activities of bladder mechanosensitive nerve fibers of the rat?