TASK DEFINITION: Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
PROBLEM: To assess whether actigraphy is sensitive to benzodiazepine-induced changes in cognitive and psychomotor performance and sleep.', 'Healthy young volunteers (n = 23; 11 males), were randomised to a double-blind, placebo-controlled, crossover trial. Actigraphy was used to record motor activity continuously. Following dosing at 18.00 h with 2.5 mg lorazepam (LZP), psychomotor and cognitive assessments were made at hourly intervals post-dose for 4 h and after sleep at 14.5 h post-dose.', 'Activity levels were significantly reduced after LZP for 5 h post-dose (p = 0.0104), during sleep (5-13 h) (p < 0.02) and the following morning, 13-14.5 h post-dose (p < 0.02). At the same time cognitive and psychomotor performance was also significantly impaired (p < 0.05). LZP also significantly increased actigraphic sleep efficiency and sleep per cent (p < 0.02).

SOLUTION: Does benzodiazepine-induced reduction in activity mirror decrements in cognitive and psychomotor performance?

PROBLEM: Islet function is regulated by islet autonomic nerves. These nerves harbour not only the classical neurotransmitters, acetyl choline and noradrenaline, but also neuropeptides. This study examined whether the neuropeptides, pituitary adenylate cyclase activating polypeptide (PACAP) and gastrin releasing polypeptide (GRP) contribute to the regulation of insulin secretion in model experiments by using receptor gene deleted mice.', 'Anaesthetized mice with genetic deletion of one of the PACAP receptors (PAC1 receptors) or one of the GRP receptors (GRP receptor) or their wildtype counterparts were given glucose through a gastric gavage (150 mg) or intravenously (0.25, 0.50 or 1 g/kg). Blood samples were taken regularly during the following 120 min (after gastric glucose) or at 1 min (after intravenous glucose) for analysis of glucose and insulin.', 'The insulin response to gastric glucose was suppressed by 66% in PAC1 receptor gene deleted mice in association with impaired glucose elimination, whereas the insulin response to intravenous glucose was impaired by 36% only. The insulin response to glucose was suppressed in GRP receptor gene deleted mice by 24% together with impaired glucose elimination, whereas the insulin response to intravenous glucose was not significantly suppressed.

SOLUTION: Is the insulin response to gastric glucose reduced in PAC1 and GRP receptor gene deleted mice?

PROBLEM: The purpose of this study was to describe patient satisfaction in general practice among the Sami monolingual population, as compared with the Norwegian population.', "The data was collected in 2002-2004 through a health survey in communities with Sami and Norwegian population, SAMINOR. The analyses included 15,612 men and women between 36 and 79 years, with a response rate of 60.1%. The questionnaire included questions about patients' satisfaction with primary care and what language they spoke at home.", "The monolingual Sami population was less satisfied with the primary health care than the Norwegian population, RR 2.4 (95% CI 2.1-2.7) and also less satisfied with the physicians' language skills, RR 5.8 (95% CI 4.8-7.0). Frequent misunderstandings between the physician and the patient based on language difficulty were also reported, RR 3.8 (95% CI 3.3-4.3). In addition, approximately one third of the Sami did not want to have an interpreter in on the consultation.

SOLUTION:
Is [ The monolingual Sami population less satisfied with the primary health care ]?