Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
In a brief period between World War I and World War II the Kingdom of Yugoslavia, successor to the Kingdom of Serbia, formed a ''Small Entente'' loose union between Czechoslovakia, Romania and Yugoslavia.

Ex Output:
Which replaced the Kingdom of Serbia?

Ex Input:
SET domain methyltransferases deposit methyl marks on specific histone tail lysine residues and play a major role in epigenetic regulation of gene transcription. We solved the structures of the catalytic domains of GLP, G9a, Suv39H2 and PRDM2, four of the eight known human H3K9 methyltransferases in their apo conformation or in complex with the methyl donating cofactor, and peptide substrates. We analyzed the structural determinants for methylation state specificity, and designed a G9a mutant able to tri-methylate H3K9. We show that the I-SET domain acts as a rigid docking platform, while induced-fit of the Post-SET domain is necessary to achieve a catalytically competent conformation. We also propose a model where long-range electrostatics bring enzyme and histone substrate together, while the presence of an arginine upstream of the target lysine is critical for binding and specificity. This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1.

Ex Output:
What is the characteristic domain of histone methyltransferases?

Ex Input:
To define the relationship between body indices of healthy adults and cross-sectional areas of the carpal tunnel and median nerve and to obtain the nerve/tunnel index, which represents a new standard for diagnosing carpal tunnel syndrome using sonography. Body indices (height, weight, and body mass index) were analyzed in 60 healthy adults, and electromyography and sonography were also performed. The cross-sectional areas of the proximal and distal median nerve and carpal tunnel were obtained by sonography. The proximal and distal nerve/tunnel indices were obtained by calculating the ratio between the proximal and distal cross-sectional areas of the median nerve to those of the carpal tunnel and multiplying the value by 100. Although the proximal cross-sectional areas of the median nerve and body indices showed statistically significant relationships with weak positive correlations, the proximal and distal areas of the carpal tunnel showed relatively stronger correlations with body indices. Between sexes, there were significant differences in the proximal median nerve cross-sectional area (mean SD: male, 10.48 3.21 mm(2); female, 8.81 3.21 mm(2); P < .05) and proximal carpal tunnel area (male, 182.50 21.15 mm(2); female, 151.23 21.14 mm(2); P < .05). There was no difference in the proximal nerve/tunnel index (male, 5.80% 1.72%; female, 5.91% 1.63%). There was a statistically significant difference in the distal carpal tunnel cross-sectional area (male, 138.90 20.95 mm(2); female, 121.50 18.99 mm(2); P < .05) between sexes, but the distal median area (male, 9.99 3.42 mm(2); female, 8.46 1.84 mm(2)) and distal nerve/tunnel index (male, 7.15% 2.00%; female, 7.01% 1.38%) showed no significant differences. The proximal index was significantly higher than the distal index (proximal, 5.85% 1.66%; distal, 7.08% 1.71%). The nerve/tunnel index is unaffected by body indices or sex and thus may be a useful and objective standard for diagnosing carpal tunnel syndrome.

Ex Output:
What nerve is involved in carpal tunnel syndrome?