Input: Read this: TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate within endosomes of alveolar macrophages. Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis. During this process, the bacterium is enveloped by the macrophage and stored temporarily in a membrane-bound vesicle called a phagosome. The phagosome then combines with a lysosome to create a phagolysosome. In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium. However, M. tuberculosis has a thick, waxy mycolic acid capsule that protects it from these toxic substances. M. tuberculosis is able to reproduce inside the macrophage and will eventually kill the immune cell.
Question: What does the combination of a lysosome and a phagolysosome create?

Output: unanswerable

Input: Read this: When infection attacks the body, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic; including antitubercular), antiviral, antifungal and antiparasitic (including antiprotozoal and antihelminthic) agents. Depending on the severity and the type of infection, the antibiotic may be given by mouth or by injection, or may be applied topically. Severe infections of the brain are usually treated with intravenous antibiotics. Sometimes, multiple antibiotics are used in case there is resistance to one antibiotic. Antibiotics only work for bacteria and do not affect viruses. Antibiotics work by slowing down the multiplication of bacteria or killing the bacteria. The most common classes of antibiotics used in medicine include penicillin, cephalosporins, aminoglycosides, macrolides, quinolones and tetracyclines.[citation needed]
Question: How do antibiotics work?

Output: slowing down the multiplication of bacteria or killing the bacteria

Input: Read this: After dynastic quarrels however, there was a Christian reconquest in 1072. The family who returned the city to Christianity were called the Hautevilles, including Robert Guiscard and his army, who is regarded as a hero by the natives. It was under Roger II of Sicily that Norman holdings in Sicily and the southern part of the Italian Peninsula were promoted from the County of Sicily into the Kingdom of Sicily. The Kingdom's capital was Palermo, with the King's Court held at the Palazzo dei Normanni. Much construction was undertaken during this period, such as the building of Palermo Cathedral. The Kingdom of Sicily became one of the wealthiest states in Europe.
Question: How did the Kingdom of Sicily compare monetarily with the other European staes?

Output: one of the wealthiest states in Europe

Input: Read this: The traditional Greek homelands have been the Greek peninsula and the Aegean Sea, the Southern Italy (Magna Graecia), the Black Sea, the Ionian coasts of Asia Minor and the islands of Cyprus and Sicily. In Plato's Phaidon, Socrates remarks, "we (Greeks) live around a sea like frogs around a pond" when describing to his friends the Greek cities of the Aegean. This image is attested by the map of the Old Greek Diaspora, which corresponded to the Greek world until the creation of the Greek state in 1832. The sea and trade were natural outlets for Greeks since the Greek peninsula is rocky and does not offer good prospects for agriculture.
Question: When did changes of this ancient map not become notable?

Output:
unanswerable