In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved the 4.2 A resolution structure of the type 1 pilus rod using cryo-electron microscopy. Residues forming the interactive surfaces that determine the mechanical properties of the rod were maintained by selection based on a global alignment of fimA sequences. We identified mutations that did not alter pilus production in vitro but reduced the force required to unwind the rod. UPEC expressing these mutant pili were significantly attenuated in bladder infection and intestinal colonization in mice. This study elucidates an unappreciated functional role for the molecular spring-like property of type 1 pilus rods in host-pathogen interactions and carries important implications for other pilus-mediated diseases.
Title: Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

A: False
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Q: Paragraph: Background: Hirschsprung's disease (HSCR) is a type of megacolon induced by defi ciency or dysfunction of ganglion cells in the distal intestine and is associated with developmental disorders of the enteric nervous system. To explore the mechanisms of HSCR, we analyzed the RNAsequencing data of the expansion and the narrow segments of colon tissues separated from children with HSCR. Methods: RNA-sequencing of the expansion segments and the narrow segments of colon tissues isolated from children with HSCR was performed. After differentially expressed genes (DEGs) were identified using the edgeR package in R, functional and pathway enrichment analyses of DEGs were carried out using DAVID software. To further screen the key genes, protein-protein interaction (PPI) network and module analyses were conducted separately using Cytoscape software. Results: A total of 117 DEGs were identified in the expansion segment samples, including 47 up-regulated and 70 down-regulated genes. Functional enrichment analysis suggested that FOS and DUSP1 were implicated in response to endogenous stimulus. In the PPI network analysis, FOS (degree=20), EGR1 (degree=16), ATF3 (degree=9), NOS1 (degree=8), CCL5 (degree=8), DUSP1 (degree=7), CXCL3 (degree=6), VIP (degree=6), FOSB (degree=5), and NOS2 (degree=4) had higher degrees, which could interact with other genes. In addition, two significant modules (module 1 and module 2) were identifi ed from the PPI network. Conclusion: Several genes (including FOS, EGR1, ATF3, NOS1, CCL5, DUSP1, CXCL3, VIP, FOSB, and NOS2) might be involved in the development of HSCR through their effect on the nervous system. World J Pediatr 2017;13(3):267-273
Title: Genes involved in HSCR Identifying key genes associated with Hirschsprung's disease based on bioinformatics analysis of RNA-sequencing data

A: False
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Q: Paragraph: Acute respiratory infections (ARI) are a major cause of morbidity worldwide. 1 Some of the earliest studies to describe the epidemiology of these infections were household cohort studies. [2] [3] [4] [5] [6] [7] The largest of these were conducted in Seattle, Washington and Tecumseh, Michigan in the 1960s and 1970s 6,7 and they provided information on the relative frequency, seasonality and symptomatic characteristics of ARI shortly after many respiratory viruses were first identified. 7 Given that the role of household structure in seasonal incidence and transmission of respiratory viruses was the primary objective, an individual's longitudinal history of infection was not a major focus. Indeed, during the first phase of the Tecumseh Study of Respiratory Illness, households were maintained on report for only 1 year, and then gradually replaced so that the entire community could be represented over time. 8 These historical studies relied on cell culture for virus identification, a method that requires specimens to be processed quickly and is considerably less sensitive than current molecular methods. 9 For this reason, the Tecumseh study and others relied extensively on serodiagnosis of influenza infection using twice yearly blood specimens. 10 It was not possible to time infections in those who only were serologically positive, limiting the ability to do robust analyses of transmission patterns. 11 With current molecular techniques, it has become much easier to identify a broad range of agents of respiratory infection. This allows documentation of infection, co-infection and subsequent re-infection. Collecting specimens within a short time from the onset of symptoms still maximizes the likelihood of accurate and timely identification of viruses associated with a respiratory illness for studies of transmission and vaccine effectiveness. Collection of regular blood specimens continues to be valuable as well, for both virus identification and for analysis of serologic correlates of protection. The Household Influenza Vaccine Evaluation (HIVE) Study is an ongoing prospective household cohort study that began in 2010. The HIVE Study was based on the original Tecumseh Study of Respiratory Illness 6 with several key modifications to illness surveillance and to laboratory methods for identification of respiratory viruses. While respiratory virus infections in general could be studied, the primary objective was to estimate the effectiveness of influenza vaccines using a cohort design for comparison with studies using the testnegative design (TND). Under the TND, specimens are collected from participants who meet a respiratory illness case V C The Author(s)
Title: Data Resource Profile Data resource profile: Household Influenza Vaccine Evaluation (HIVE) Study Data resource basics

A:
True
****