Please answer the following question: Information: - Henry VI (6 December 1421 21 May 1471) was King of England from 1422 to 1461 and again from 1470 to 1471, and disputed King of France from 1422 to 1453. The only child of Henry V, he succeeded to the English throne at the age of nine months upon his father's death, and succeeded to the French throne on the death of his grandfather Charles VI shortly afterwards. Henry inherited the long-running Hundred Years War (13371453), where Charles VII contested his claim to the French throne. Henry married Charles's niece, Margaret of Anjou, partially in the hope of achieving peace in 1445, but the policy failed, leading to the murder of William de la Pole, one of Henry's key advisors. The war recommenced, with France taking the upper hand; by 1453, Calais was Henry's only remaining territory on the continent. - Anjou is an historical and cultural region of France, a former French county (in that it was ruled by a count, from ), duchy (1360), and province. Its capital was the city of Angers in the lower Loire Valley. The territory has no very clear geographical borders but instead owes its territory and prominence to the fortunes of its various rulers. - Rene of Anjou (14091480), also known as Rene I of Naples and Good King Rene, was count of Piedmont, Duke of Bar (143080), Duke of Lorraine (143153), Duke of Anjou, Count of Provence (143480), King of Naples (143542; titular 144280), titular King of Jerusalem (143880) and Aragon including Sicily, Majorca and Corsica (146680). - The House of Valois-Anjou was a noble French family, deriving from the royal family, the House of Valois. They were monarchs of Naples, as well as various other territories. - Isabella ( 1400 -- 28 February 1453 ) was suo jure Duchess of Lorraine , from 25 January 1431 to her death in 1453 . She was the first wife of Duke Rene of Anjou , King of Naples , and the mother of his children , which included Margaret of Anjou , Queen consort of England as the wife of Henry VI . From 1435 - 42 , she was Queen consort of Naples , and from 1442 until her death she was the titular queen consort . During her husband 's absences , she acted as regent for his domains . - Margaret of Anjou (23 March 1430 25 August 1482) was the wife of King Henry VI of England. As such, she was Queen of England from 1445 to 1461 and again from 1470 to 1471. Born in the Duchy of Lorraine into the House of Valois-Anjou, Margaret was the second eldest daughter of Rene of Anjou and Isabella, Duchess of Lorraine. Given the information above, choose from the list below the object entity that exhibits the relation 'noble title' with the subject 'isabella'. Choices: - count - duke - duke of anjou - duke of bar - duke of lorraine - king - noble
A:
duke of lorraine