Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Imatinib was the first BCR-ABL tyrosine kinase inhibitor to become clinically available. In this study, we retrospectively evaluated the long-term efficacy of low-dose imatinib (final maintenance dose <300mg per day) due to intolerance, in comparison to optimal-dose imatinib (300mg per day) in patients with Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase. The Kaplan-Meier estimates of the median time to complete cytogenetic response, major molecular response, and complete molecular response were longer for 31 patients receiving low-dose imatinib (360, 1360, and 1420days, respectively) than 74 patients receiving optimal-dose imatinib (170, 420, and 720days, respectively). However, the differences in response shrank over time and progression-free survival were comparable between the two groups. These findings suggest that long-term treatment with low-dose imatinib is an acceptable alternative for patients with intolerance to the optimal dose.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Ex Input:
Weathering is the process that changes solid rock into sediments. Sediments were described in the chapter "Ma- terials of Earths Crust." With weathering, rock is disintegrated. It breaks into pieces. Once these sediments are separated from the rocks, erosion is the process that moves the sediments. While plate tectonics forces work to build huge mountains and other landscapes, the forces of weathering gradually wear those rocks and landscapes away. Together with erosion, tall mountains turn into hills and even plains. The Appalachian Mountains along the east coast of North America were once as tall as the Himalayas. No human being can watch for millions of years as mountains are built, nor can anyone watch as those same mountains gradually are worn away. But imagine a new sidewalk or road. The new road is smooth and even. Over hundreds of years, it will completely disappear, but what happens over one year? What changes would you see? (Figure 1.1). What forces of weathering wear down that road, or rocks or mountains over time? A once smooth road surface has cracks and fractures, plus a large pothole. Click image to the left or use the URL below. URL:

Ex Output:
the process that changes solid rock into sediments.

Ex Input:
Most fossils are preserved by one of five processes outlined below (Figure 1.1): Most uncommon is the preservation of soft-tissue original material. Insects have been preserved perfectly in amber, which is ancient tree sap. Mammoths and a Neanderthal hunter were frozen in glaciers, allowing scientists the rare opportunity to examine their skin, hair, and organs. Scientists collect DNA from these remains and compare the DNA sequences to those of modern counterparts. The most common method of fossilization is permineralization. After a bone, wood fragment, or shell is buried in sediment, mineral-rich water moves through the sediment. This water deposits minerals into empty spaces and Five types of fossils: (a) insect preserved in amber, (b) petrified wood (permineralization), (c) cast and mold of a clam shell, (d) pyritized ammonite, and (e) compression fossil of a fern. produces a fossil. Fossil dinosaur bones, petrified wood, and many marine fossils were formed by permineralization. When the original bone or shell dissolves and leaves behind an empty space in the shape of the material, the depression is called a mold. The space is later filled with other sediments to form a matching cast within the mold that is the shape of the original organism or part. Many mollusks (clams, snails, octopi, and squid) are found as molds and casts because their shells dissolve easily. The original shell or bone dissolves and is replaced by a different mineral. For example, calcite shells may be replaced by dolomite, quartz, or pyrite. If a fossil that has been replace by quartz is surrounded by a calcite matrix, mildly acidic water may dissolve the calcite and leave behind an exquisitely preserved quartz fossil. Some fossils form when their remains are compressed by high pressure, leaving behind a dark imprint. Compression is most common for fossils of leaves and ferns, but can occur with other organisms. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:

Ex Output:
the most common way that fossil leaves are made is by