In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: The activation energy of a reaction:
Options: <1> It is not modified by the action of enzymes. <2> It is the energy necessary to reach the state of transition. <3> It is lower than the energy of the substrates. <4> It is lower than the energy of the products. <5> It is an average of the value of G of the reaction.
2