De novo or "orphan" genes, whose sequence shows no similarity to existing genes, are extremely rare. Estimates of the number of de novo genes in the human genome range from 18 to 60. Such genes are typically shorter and simpler in structure than most eukaryotic genes, with few if any introns. Two primary sources of orphan protein-coding genes are gene duplication followed by extremely rapid sequence change, such that the original relationship is undetectable by sequence comparisons, and formation through mutation of "cryptic" transcription start sites that introduce a new open reading frame in a region of the genome that did not previously code for a protein.
What is the estimate of the number of orphan genes in the human genome?
18 to 60

Antigonus then sent his son Demetrius to regain control of Greece. In 307 he took Athens, expelling Demetrius of Phaleron, Cassander's governor, and proclaiming the city free again. Demetrius now turned his attention to Ptolemy, defeating his fleet at the Battle of Salamis and taking control of Cyprus. In the aftermath of this victory, Antigonus took the title of king (basileus) and bestowed it on his son Demetrius Poliorcetes, the rest of the Diadochi soon followed suit. Demetrius continued his campaigns by laying siege to Rhodes and conquering most of Greece in 302, creating a league against Cassander's Macedon.
Who bestowed the title of king to Demetrius Poliorcetes?
Antigonus

The etymology of the name Bern is uncertain. According to the local legend, based on folk etymology, Berchtold V, Duke of Zahringen, the founder of the city of Bern, vowed to name the city after the first animal he met on the hunt, and this turned out to be a bear. It has long been considered likely that the city was named after the Italian city of Verona, which at the time was known as Bern in Middle High German. As a result of the find of the Bern zinc tablet in the 1980s, it is now more common to assume that the city was named after a pre-existing toponym of Celtic origin, possibly *berna "cleft". The bear was the heraldic animal of the seal and coat of arms of Bern from at least the 1220s. The earliest reference to the keeping of live bears in the Barengraben dates to the 1440s.
What is the common assumption of what Bern was named after?
a pre-existing toponym of Celtic origin, possibly *berna "cleft"