Problem: Ishallshowthatthemaximalwork,whichwascarriedoutintheUniverse,whenitwas'born'withinthefirstcosmicquantumtimeinterval,isgivenbythetotalmassoftheUniversemultipliedbythesquareofthevelocityoflight.
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I shall show that the maximal work, which was carried out in the Universe, when it was 'born' within the first cosmic quantum time interval, is given by the total mass of the Universe multiplied by the square of the velocity of light.

Problem: Girlaftergirlcametothetribuneover-dressed,fashion-apinglittlegirls,withpinchedfacesandleakyshoes.
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Girl after girl came to the tribuneover-dressed, fashion-aping little girls, with pinched faces and leaky shoes.

Problem: Tissuemodelswithhigherphysiologicalrelevanceareneededtopredicttheefficacyandsafetyofcompoundsbeforeadmittingthemtoclinicaltrials.Recently,standardinvitrocellculturetechniqueshaveevolvedfromtwo-dimensionalmonolayerculturestowardthree-dimensionalmulti-cellularmodels,aimingtomimictheinvivotissuemicroenvironment.
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Tissue models with higher physiological relevance are needed to predict the efficacy and safety of compounds before admitting them to clinical trials. Recently, standard in vitro cell culture techniques have evolved from two-dimensional monolayer cultures toward three-dimensional multi-cellular models, aiming to mimic the in vivo tissue microenvironment.

Problem: Iftherearequitecommonlycreatedwindwavesonthecropsurfaceinthefield(wonderful;photo,video;Manythanksforexplaining,Mr.Vetvicka),thereforeisalsopossiblethataftertheimpactofthesteppulsefromabove,thatisoneofpossibleveryprecisecharacteristicsofthelightningdischarge,createcircularwavesexactlyinthesameway,likeonthewatersurfaceafterastonefallingthere.Itdependsonlyonthetimeinterval,afterthathitsthesubsequentstroke,"makingexposition",andhowthecirclesfrompreviousdischargeswereabletodevelop.
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If there are quite commonly created wind waves on the crop surface in the field (wonderful; photo, video; Many thanks for explaining, Mr. Vetvicka ), therefore is also possible that after the impact of the step pulse from above, that is one of possible very precise characteristics of the lightning discharge, create circular waves exactly in the same way, like on the water surface after a stone falling there. It depends only on the time interval, after that hits the subsequent stroke, "making exposition", and how the circles from previous discharges were able to develop.