Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P.05), and naproxen resulted in significant improvement of LBPI vs placebo (P.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.

Ex Output:
What is the target of tanezumab?

Ex Input:
A significant role for IFN in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFN monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more significant clinical manifestations. At the same time, evidence supports an anti-inflammatory and beneficial role of IFN locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFN. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease - particularly at local sites of inflammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quantification of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents.

Ex Output:
Which is the most common gene signature in Rheumatoid Arthritis patients?

Ex Input:
The outcrop in the Figure 1.1 is at Checkerboard Mesa in Zion National Park, Utah. It has a very interesting pattern on it. As a geology student you may ask: how did this rock form? If you poke at the rock and analyze its chemistry you will see that its made of sand. In fact, the rock formation is called the Navajo sandstone. But knowing that the rock is sandstone doesnt tell you how it formed. It would be hard to design an experiment to show how this rock formed. But we can make observations now and apply them to this rock that formed long ago. James Hutton came up with this idea in the late 1700s. The present is the key to the past. He called this the principle of uniformitarianism. It is that if we can understand a geological process now and we find evidence of that same Checkerboard Mesa in Zion National Park, Utah. process in the past, then we can assume that the process operated the same way in the past. Hutton speculated that it has taken millions of years to shape the planet, and it is continuing to be changed. He said that there are slow, natural processes that changed, and continue to change, the planets landscape. For example, given enough time, a stream could erode a valley, or sediment could accumulate and form a new landform. Lets go back to that outcrop. What would cause sandstone to have layers that cross each other, a feature called cross-bedding? In the photo of the Mesquite sand dune in Death Valley National Park, California (Figure 1.2), we see that wind can cause cross-bedding in sand. Cross-bedding is due to changes in wind direction. There are also ripples caused by the wind waving over the surface of the dune. Since we can observe wind forming sand dunes with these patterns now, we have a good explanation for how the Navajo sandstone formed. The Navajo sandstone is a rock formed from ancient sand dunes in which wind direction changed from time to time. This is just one example of how geologists use observations they make today to unravel what happened in Earths past. Rocks formed from volcanoes, oceans, rivers, and many other features are deciphered by looking at the geological work those features do today. Click image to the left or use the URL below. URL:

Ex Output:
geologists can identify that wind changed direction in ancient sandstone from