Q: Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
Context: Tumor necrosis factor- converting enzyme (TACE) has been demonstrated to be involved in liver inflammation. However, the significance of TACE methylation in acute-on-chronic hepatitis B liver failure (ACHBLF) has not been demonstrated. This study aims to evaluate TACE methylation status in ACHBLF and determine its predictive value for prognosis.', 'Forty-five patients with ACHBLF, 80 with chronic hepatitisB (CHB) and 54 healthy controls (HCs) were enrolled. The methylation status of TACE promoter was determined by methylation-specific polymerase chain reaction. The TACE mRNA expression was determined by quantitative real-time polymerase chain reaction. The plasma levels of TACE, TNF-, sTNFRI, sTNFRII were measured by enzyme-linked immunosorbent assay.', 'TACE methylation was significantly lower in patients with ACHBLF than those with CHB ((2)=24.69, P<0.01) and HCs ((2)=35.93, P<0.01). Meanwhile, TACE methylation was significantly lower in CHB patients than HCs ((2)=4.03, P<0.05). TACE methylation was significantly inversely associated with its mRNA expression (r=-0.68; P<0.01). The plasma levels of TACE, TNF-, sTNFRI, sTNFRII were significantly higher in patients with ACHBLF than those with CHB (P<0.05, respectively) and HCs (P<0.05, respectively). In patients with ACHBLF, significantly higher prothrombin activity, lower total bilirubin and MELD score were found in TACE methylated group than unmethylated group (P<0.05). ACHBLF patients with methylated TACE showed significantly better survival than those without (P<0.01).
Answer: This study showed that demethylation of TACE promoter occurred in ACHBLF and might serve as a potential prognostic marker.
A:
Does demethylation of tumor necrosis factor- converting enzyme predict poor prognosis in acute-on-chronic hepatitis B liver failure?