instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Mannose-binding lectin (MBL) is a key soluble pathogen recognition protein of the innate immune system that binds specific mannose-containing glycans on the surfaces of microbial agents and initiates complement activation via the lectin pathway. Prior studies showed that MBL-dependent activation of the complement cascade neutralized insect cell-derived West Nile virus (WNV) in cell culture and restricted pathogenesis in mice. Here, we investigated the antiviral activity of MBL in infection by dengue virus (DENV), a related flavivirus. Using a panel of naive sera from mouse strains deficient in different complement components, we showed that inhibition of infection by insect cell-and mammalian cell-derived DENV was primarily dependent on the lectin pathway. Human MBL also bound to DENV and neutralized infection of all four DENV serotypes through complement activation-dependent and -independent pathways. Experiments with human serum from naive individuals with inherent variation in the levels of MBL in blood showed a direct correlation between the concentration of MBL and neutralization of DENV; samples with high levels of MBL in blood neutralized DENV more efficiently than those with lower levels. Our studies suggest that allelic variation of MBL in humans may impact complement-dependent control of DENV pathogenesis. Citation Avirutnan P, et al. 2011. Complement-mediated neutralization of dengue virus requires mannose-binding lectin. mBio 2(6):e00276-11.
Title: Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin
answer:
True

question:
Paragraph: LETTERS that the quantitative assessment of the effectiveness of public health intervention measures for SARS is a difficult task for modelers. To make models useful for assessing the effects of specific intervention measures and for predicting the future dynamics during an ongoing epidemic, we need improved knowledge on the transmission mechanisms, pathogenesis, and the epidemiologic determinants of the spread of the virus. Any retrospective analysis of the 2003 SARS epidemic that improves our knowledge of SARS epidemiology is welcome.
Title: SARS epi-demiology and cumulative case curve
answer:
False

question:
Paragraph: Human populations worldwide are increasingly confronted with infectious diseases and antimicrobial resistance spreading faster and appearing more frequently. Knowledge regarding their occurrence and worldwide transmission is important to control outbreaks and prevent epidemics. Here, we performed shotgun sequencing of toilet waste from 18 international airplanes arriving in Copenhagen, Denmark, from nine cities in three world regions. An average of 18.6 Gb (14.8 to 25.7 Gb) of raw Illumina paired end sequence data was generated, cleaned, trimmed and mapped against reference sequence databases for bacteria and antimicrobial resistance genes. An average of 106,839 (0.06%) reads were assigned to resistance genes with genes encoding resistance to tetracycline, macrolide and beta-lactam resistance genes as the most abundant in all samples. We found significantly higher abundance and diversity of genes encoding antimicrobial resistance, including critical important resistance (e.g. bla CTX-M ) carried on airplanes from South Asia compared to North America. Presence of Salmonella enterica and norovirus were also detected in higher amounts from South Asia, whereas Clostridium difficile was most abundant in samples from North America. Our study provides a first step towards a potential novel strategy for global surveillance enabling simultaneous detection of multiple human health threatening genetic elements, infectious agents and resistance genes. Globally, infectious diseases are the cause of about 22% of all human deaths 1 . Due to increasing population density, increasing use of antimicrobial agents, disruption of wildlife habitats, and an increase in global travel and trade this number has been estimated to increase in coming years 2,3 . Rapid global surveillance systems for early detection of worldwide spread of zoonotic and human pathogens would enable outbreak control and epidemic prevention 4,5 . In addition to the direct severe consequences for human health, infectious diseases may cause an increased financial burden on health systems and may imply restriction on travel, trade, etc. Global spread of antimicrobial resistance in bacterial pathogens is another major threat against human health, yet we don't know much about how these genes travel and spread worldwide 6 . Current international disease surveillance system is mainly based on reports made by doctors after treatment of infected patients 7 . It has been attempted to establish regional and global networks, for the
Title: Meta-genomic analysis of toilet waste from long distance flights; a step towards global surveillance of infectious diseases and antimicrobial resistance OPEN
answer:
True