Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35. Within each repeat unit is a gene, DUX4, that can encode a protein containing two homeodomains. A DUX4 transcript derived from the last repeat unit in a contracted array is associated with pathogenesis but it is unclear how. Using exon-based microarrays, the expression profiles of myogenic precursor cells were determined. Both undifferentiated myoblasts and myoblasts differentiated to myotubes derived from FSHD patients and controls were studied after immunocytochemical verification of the quality of the cultures. To further our understanding of FSHD and normal myogenesis, the expression profiles obtained were compared to those of 19 non-muscle cell types analyzed by identical methods. Many of the ~17,000 examined genes were differentially expressed (>2-fold, p<0.01) in control myoblasts or myotubes vs. non-muscle cells (2185 and 3006, respectively) or in FSHD vs. control myoblasts or myotubes (295 and 797, respectively). Surprisingly, despite the morphologically normal differentiation of FSHD myoblasts to myotubes, most of the disease-related dysregulation was seen as dampening of normal myogenesis-specific expression changes, including in genes for muscle structure, mitochondrial function, stress responses, and signal transduction. Other classes of genes, including those encoding extracellular matrix or pro-inflammatory proteins, were upregulated in FSHD myogenic cells independent of an inverse myogenesis association. Importantly, the disease-linked DUX4 RNA isoform was detected by RT-PCR in FSHD myoblast and myotube preparations only at extremely low levels. Unique insights into myogenesis-specific gene expression were also obtained. For example, all four Argonaute genes involved in RNA-silencing were significantly upregulated during normal (but not FSHD) myogenesis relative to non-muscle cell types. DUX4's pathogenic effect in FSHD may occur transiently at or before the stage of myoblast formation to establish a cascade of gene dysregulation. This contrasts with the current emphasis on toxic effects of experimentally upregulated DUX4 expression at the myoblast or myotube stages. Our model could explain why DUX4's inappropriate expression was barely detectable in myoblasts and myotubes but nonetheless linked to FSHD.
Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?

In 1991, the governments of the U.S. and China are on the verge of a major trade agreement, with the President of the United States due to visit China to seal the deal. The CIA learns that its asset Tom Bishop (Brad Pitt) has been captured trying to free a Briton, Elizabeth Hadley (Catherine McCormack), from a People's Liberation Army prison in Su Chou near Shanghai, China. Bishop is being questioned under torture and will be executed in 24 hours unless the U.S. government claims him. If the CIA claims Bishop as an agent, they risk jeopardizing the trade agreement. Exacerbating Bishop's situation is the fact that he was operating without permission from the Agency. Attempting to deal quickly with the situation, CIA executives call in Nathan Muir (Robert Redford), an aging mid-level case officer on his last day before retirement and the man who recruited Bishop. Although they tell Muir they simply need him to act as a "stop gap" to fill in some holes in their background files, the officials are hoping he will give them the pretext they need to justify letting Bishop die. The CIA executives are unaware that Muir had been tipped off about Bishop's capture prior to arriving at the CIA's headquarters, by fellow CIA veteran Harry Duncan (David Hemmings), for whom Bishop had been working an operation in Hong Kong before going rogue. Muir first attempts to save Bishop by leaking the story to CNN through a contact in Hong Kong, believing that public pressure would force the CIA to rescue Bishop. The tactic only stalls them, however, and is stymied when a phone call to the U.S. Federal Communications Commission from CIA Deputy Director Charles Harker (Stephen Dillane) results in CNN retracting the story. During the debriefing, Muir describes how he recruited Bishop for an operation when Bishop was a U.S. Marine scout sniper during the Vietnam War. Muir also discusses their 1976 tour of duty in Berlin, Germany, where Bishop was tasked with procuring East German assets, with Muir commanding, as well as Bishop's spy work in Beirut, Lebanon in 1985 during the War of the Camps, the latter being the last time the two saw each other. During the mission in Lebanon, Bishop met Hadley, and the two began developing romantic feelings for each other. However, it is revealed that Hadley was involved in a bombing of the Chinese embassy in Britain, causing her to flee the country. Fearing that Bishop's feelings for Hadley might compromise his cover and the mission, Muir tips off the Chinese to Hadley's location in return for freeing an arrested U.S. diplomat. Chinese agents kidnap Hadley, and Bishop cuts all ties to Muir when he discovers his involvement. After learning Hadley was the target of Bishop's rescue attempt, Muir finally realizes that he has greatly underestimated Bishop's feelings for her. Running out of time, Muir secretly creates a forged urgent operational directive from the CIA director to commence Operation Dinner Out, a rescue mission to be spearheaded by Commander Wiley's (Dale Dye) U.S. Navy SEAL team, for which Bishop had laid the groundwork as a "Plan B" for his own rescue attempt. Using US$282,000 of his life savings and a misappropriated file on Chinese coastline satellite imagery, Muir enlists Duncan's help in bribing a Chinese energy official to cut power to the prison for 30 minutes, during which time the SEAL rescue team retrieves Bishop and Hadley. Bishop, who is rescued at the end of the film 15 minutes before his scheduled execution, realizes Muir was behind his rescue when he recognizes the name of the plan to rescue him, Operation Dinner Out: a reference to a birthday gift that Bishop gave Muir while they were in Lebanon. When the CIA officials are belatedly informed of the rescue, Muir has already left the building and is seen driving off into the countryside.
Whats the name of the English woman?

What does population growth mean? You can probably guess that it means the number of individuals in a population is increasing. The population growth rate tells you how quickly a population is increasing or decreasing. What determines the population growth rate for a particular population? Population growth rate depends on birth rates and death rates, as well as migration. First, we will consider the effects of birth and death rates. You can predict the growth rate by using this simple equation: growth rate = birth rate death rate. If the birth rate is larger than the death rate, then the population grows. If the death rate is larger than the birth rate, what will happen to the population? The population size will decrease. If the birth and death rates are equal, then the population size will not change. Factors that affect population growth are: 1. 2. 3. 4. 5. 6. Age of organisms at first reproduction. How often an organism reproduces. The number of offspring of an organism. The presence or absence of parental care. How long an organism is able to reproduce. The death rate of offspring. For an ecosystem to be stable, populations in that system must be healthy, and that usually means reproducing as much as their environment allows. Do organisms reproduce yearly or every few years? Do organisms reproduce for much of their life, or just part of their life? Do organisms produce many offspring at once, or just a few, or even just one? Do many newborn organisms die, or do the majority survive? All these factors play a role in the growth of a population. Organisms can use different strategies to increase their reproduction rate. Altricial organisms are helpless at birth, and their parents give them a lot of care. This care is often seen in bird species. ( Figure 1.1). Altricial birds are usually born blind and without feathers. Compared to precocial organisms, altricial organisms have a longer period of development before they reach maturity. Precocial organisms, such as the geese shown below, can take care of themselves at birth and do not require help from their parents ( Figure 1.1). In order to reproduce as much as possible, altricial and precocial organisms must use very different strategies. (left) A hummingbird nest with young il- lustrates an altricial reproductive strategy, with a few small eggs, helpless young, and intensive parental care. (right) The Canada goose shows a precocial repro- ductive strategy. It lays a large number of large eggs, producing well-developed young. Migration is the movement of individual organisms into, or out of, a population. Migration affects population growth rate. There are two types of migration: 1. Immigration is the movement of individuals into a population from other areas. This increases the population size and growth rate. 2. Emigration is the movement of individuals out of a population. This decreases the population size and growth rate. The earlier growth rate equation can be modified to account for migration: growth rate = (birth rate + immigration rate) (death rate + emigration rate). One type of migration that you are probably familiar with is the migration of birds. Maybe you have heard that birds fly south for the winter. In the fall, birds fly thousands of miles to the south where it is warmer. In the spring, they return to their homes. ( Figure 1.2). Monarch butterflies also migrate from Mexico to the northern U.S. in the summer and back to Mexico in the winter. These types of migrations move entire populations from one location to another. A flock of barnacle geese fly in formation during the autumn migration. Population growth can be described with two models, based on the size of the population and necessary resources. These two types of growth are known as exponential growth and logistic growth. If a population is given unlimited amounts of resources, such as food and water, land if needed, moisture, oxygen, and other environmental factors, it will grow exponentially. Exponential growth occurs as a population grows larger, dramatically increasing the growth rate. This is shown as a "J-shaped" curve below
if the death rate is larger than the birth rate, what will happen to the population?