Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

[Q]: Context: To investigate localization and distribution of integrin subunit 1, 2 and 3 and morphological changes of ligand-recepter binding in thrombi of acute pulmonary embolism (PE) patients and explore activation of circulated immune cells, inflammatory immune adherence and coagulation response in acute venous thrombosis.', 'Thrombi were collected from patients with acute PE. Immunohistochemistry was done to detect the expression and distribution of integrin 1, 2 and 3 in cells within thrombi, and ligands of integrin subunit 1, 2 and 3 were also determined by immunohistochemistry within the thrombi.', '1) Acute venous thrombi were red thrombi composed of skeletons and filamentous mesh containing large amounts of red blood cells and white blood cells; 2) Integrin subunit 1, 2 and 3 were expressed on lymphocytes, neutrophils and platelets; 3) No expression of integrin 1 ligands: Laminin, Fibronectin, Collagen I or Collagen-II on lymphocytes; integrin 2 ligands including ICAM, factor X and iC3b are distributed on neutrophils, and ligand fibrinogen bound to neutrophils; integrin 3 was expressed on platelets which form the skeleton of thrombi and bound to fibrinogen to construct mesh structure; 4) Factor Xa was expressed on the filamentous mesh; 5) Filamentous mesh was fully filled with red blood cell dominant blood cells.
Answer: Acute venous thrombosis is an activation process of circulated lymphocytes, neutrophils and platelets mainly, and a whole process including integrin subunit 2 and 3 binding with their ligands. Activation of immune cells, inflammatory immune adherence and coagulation response are involved in the acute venous thrombosis.
[A]: Are activation of circulated immune cells and inflammatory immune adherence involved in the whole process of acute venous thrombosis?

[Q]: Context: Ficus religiosa L. is one of the most relevant members of the family of Moraceae. It is the most sacred tree of South Asia, and it is used in traditional Ayurvedic and Unani medicine to cure respiratory disorders like cough, wheezing and asthma. Some studies were performed to investigate the anti-asthmatic potential of F. religiosa bark, leaves and fruit extracts but none of them tested their antiviral activity against viruses responsible for the exacerbation of wheezing and asthma.', 'The present study was undertaken to investigate the antiviral activity of F. religiosa L. extracts against respiratory viruses such as human respiratory syncytial virus (RSV) and human rhinovirus (HRV).', 'The antiviral activity of F. religiosa L. was tested in vitro by plaque reduction and virus yield assays and the major mechanism of action was investigated by virus inactivation and time-of-addition assays.', 'F. religiosa L. methanol bark extract was the most active against HRV with an EC50 of 5.52 g/mL. This extract likely inhibited late steps of replicative cycle. Water bark extract was the most active against RSV with an EC50 between 2.23 and 4.37 g/mL. Partial virus inactivation and interference with virus attachment were both found to contribute to the anti-RSV activity. Replication of both viruses was inhibited in viral yield reduction assays.
Answer: The results of the present study demonstrate that F. religiosa L. is endowed with antiviral activity against RSV and HRV in vitro. Further work remains to be done to identify the active components and to assess the therapeutic potential in vivo.
[A]: Do ficus religiosa L. bark extracts inhibit human rhinovirus and respiratory syncytial virus infection in vitro?

[Q]: Context: Evaluate the influence of composite resin CAD-CAM restoration thickness on the in vitro fatigue resistance and failure mode of overlay-type restoration in endodontically treated premolars.', 'Thirty extracted premolars received root canal treatment followed by a standardized tooth preparation (1.5-, 2.5- or 3.5-mm cusp reduction, proximal gingival margins located 1.5mm below the CEJ, glass-ionomer base and immediately sealed dentin with Optibond FL). Restorations were milled using Cerec3 and FiltekMZ100 composite blocks. The intaglio surfaces of the overlays were sandblasted and silanated. Tooth preparations were sandblasted and etched before insertion of the restoration. All restorations were luted with Optibond FL and preheated FiltekZ100. A closed-loop servohydraulic unit was used for simulating cyclic isometric chewing at 5 Hz, starting with a load of 200 N (5000 cycles), followed by stages of 400, 600, 800, 1000, 1200 and 1400 N at a maximum of 30,000 cycles each. All samples were loaded until fracture or to a maximum of 185,000 cycles. Groups were compared using the Kaplan-Meier survival curves.', 'None of the restored premolars with the 1.5-mm cusp overlap restoration withstood all 185,000 loading cycles. With 2.5- and 3.5-mm cusp overlap, the survival rate was 30% and 40%, respectively. The rate of fracture below the CEJ was 60%, 60% and 30% for 1.5, 2.5 and 3.5 mm of cusp overlap, respectively. Survival of restored premolars with 2.5- and 3.5-mm cusp coverage was not significantly different (p=.23).
Answer: Thick FiltekMZ100 composite resin onlays showed higher fatigue resistance than thin ones and may be associated with fractures that are less subgingival.
[A]:
Does thickness of CAD-CAM composite resin overlay influences fatigue resistance of endodontically treated premolars?