In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Q: Question: The access of drugs to the central Nervous System is conditioned by the existence of the blood-brain barrier (BHE) barrier:
Options: <1> Increases its permeability in case of inflammation. <2> It is homogeneous throughout the encephalon. <3> It is traversed freely by fat-soluble drugs. <4> It is maximum in the chemoreceptor area of the trigger. <5> Decreases its permeability in case of inflammation.
A:
1