In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: What kind of validity does the degree of confidence refer to, with which it can be inferred that the cause-effect relationships between the variables of an investigation are interpretable in the sense suggested by the researcher?
Options: <1> Internal validity <2> External validity <3> Discriminant validity <4> Ecological validity <5> Construct validity
Example Output: 1

Example Input: Question: In general, allosteric enzymes:
Options: <1> They link the effectors in the active center. <2> They form covalent bonds with their negative effectors. <3> They originate hyperbolic curves of speed before the concentration of substrate. <4> They change their conformation when they link effectors. <5> They are irreversibly modified when they are inhibited.
Example Output: 4

Example Input: Question: To detect the occurrence of prerenal acute renal failure in a patient, the nurse should monitor the presence of:
Options: <1> Signs of low cardiac output. <2> Hematuria <3> Urine cloudy and smelly. <4> Colic pain <5> Elevation of creatinine clearance.
Example Output:
1