Teacher:In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.
Teacher: Now, understand the problem? Solve this instance: Context: Preventing or reducing amyloid-beta (A) accumulation in the brain is an important therapeutic strategy for Alzheimer's disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble A clearance from the brain parenchyma along the paravascular pathway. However the direct evidence for roles of AQP4 in the pathophysiology of AD remains absent.", 'Here, we reported that the deletion of AQP4 exacerbated cognitive deficits of 12-moth old APP/PS1 mice, with increases in A accumulation, cerebral amyloid angiopathy and loss of synaptic protein and brain-derived neurotrophic factor in the hippocampus and cortex. Furthermore, AQP4 deficiency increased atrophy of astrocytes with significant decreases in interleukin-1 beta and nonsignificant decreases in interleukin-6 and tumor necrosis factor-alpha in hippocampal and cerebral samples.\Question: Does deletion of aquaporin-4 in APP/PS1 mice exacerbate brain A accumulation and memory deficits?
Student:
These results suggest that AQP4 attenuates A pathogenesis despite its potentially inflammatory side-effects, thus serving as a promising target for treating AD.