Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: 1. In order to investigate the biological function of the human CLN3 gene that is defective in Batten disease, we created a yeast strain by PCR-targeted disruption of the yeast gene (YHC3), which is a homologue of the human CLN3 gene. 2. The phenotypic characterization revealed that the yhc3 delta mutants are more sensitive to combined heat and alkaline stress than the wild-type strains as determined by inhibition of cell proliferation. 3. This suggests that the yhc3 delta mutant is a good model to investigate the biological function of human CLN3 gene in mammalian cells and to understand the pathophysiology of juvenile Batten disease.
[EX A]: What is the effect of a defective CLN3 gene?

[EX Q]: Val Abbey (Abbey of St Mary of Val) (Abbaye Notre-Dame du Val) was a Cistercian abbey in Meriel and Villiers-Adam in Val-d'Oise, 30 kilometers north of Paris.
[EX A]: To which religious order did Val Abbey belong?

[EX Q]: IDW Publishing is an American publisher of comic books, graphic novels, art books and comic strip collections.
[EX A]:
The product of IDW Publishing is what?