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How to prune oleander
Prune in late summer or early fall.
On the whole, oleanders are low-maintenance plants that don't need regular pruning. However, you should aim to do a major pruning of your oleander at least once a year during late summer or early fall.
This pruning will help you shape your plant and stimulate healthy growth. Pruning at this time won't interfere with the blooming of the plant, because it is after the plant has already bloomed for the season.