instruction:
Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
question:
Context: To examine the concentration of C-reactive protein (CRP) in relation to gestational weeks during pregnancy among Chinese women.', 'From a randomized control trial of prenatal supplementation with folic acid, iron-folic acid, and multiple micronutrients in China, we examined 834 pregnant women with CRP measured initially between 5 and 20 weeks and at follow-up between 28 and 32 weeks gestation. We calculated and plotted CRP geometric means by gestational weeks. The same analysis was repeated for women who had normal pregnancies (624 women) by excluding women with stillbirth, preterm, small for gestational age, body mass index <18.5 kg/m(2) or >30 kg/m(2) at enrollment, and hypertension or anemia during pregnancy.', 'We observed a significant positive trend between log-transformed CRP and gestational age from 5 to 20 weeks and from 28 to 32 weeks both in the full sample and in the subset of women who had normal pregnancies. CRP geometric mean was 0.81 mg/l at 5-7 weeks of gestation, 2.85 mg/l at 19-20 weeks of gestation, and 3.89 mg/l at 32 weeks of gestation. A similar increasing trend in the CRP median or percentage of elevated CRP were also observed.
Answer: We concluded that CRP increased with gestational age among healthy Chinese women who delivered healthy infants. Am. J. Hum. Biol. 28:574-579, 2016. ©️ 2016 Wiley Periodicals, Inc.
answer:
Does c-reactive protein increase with gestational age during pregnancy among Chinese women?

question:
Context: Barrett esophagus (BE) is considered precursor condition of esophageal adenocarcinoma. Its incidence and prevalence are increasing in general population. Studies reported that metabolic syndrome (MS) or diabetes mellitus (DM) is related to increased risk of BE. Current study was to assess and better understand the relationship between MS /DM and BE.', "Electronic search was conducted in the database Pubmed/Medline (-December, 2015), Embase (-December, 2015), Cochrane Library (-December, 2015), and Web of Knowledge (-December, 2015). Studies included were assessed with summary odds ratios (ORs) with 95% confidence intervals (CIs) and compared exposure group with control group. The heterogeneity was examined by the funnel plot and the Egger's test. Subgroup analyses and sensitive analyses were performed for the detection of possible heterogeneity and impact on stability of analysis results.", "Twelve publications met the criteria and included 355,311 subjects were analyzed. The pooled results showed MS was closely associated with increased risk of BE (OR=1.23; 95%CI 1.03-1.47; P=0.024), and yet DM did not significantly increase the risk of BE (OR=1.07; 95%CI 0.82-1.38; P=0.627). Substantial heterogeneities were detected. No significant publication bias was detected by Egger's test (P=0.23).
Answer: Based on the results of current meta-analysis, MS is associated with increased risk of BE. Further long-term follow-up prospective study needs to verify the current results, and definite pathophysiological mechanism needs to be further investigated and clearly elucidated.
answer:
Is metabolic syndrome associated with increased risk of Barrett esophagus : A meta-analysis?

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Context: To evaluate the relationship between cerebral oxygen saturation and neuropsychological dysfunction after cardiac surgery.', 'Prospective and observational study.', 'Operating room and cardiac floor of a university hospital.', 'One hundred one patients undergoing elective cardiac surgery with cardiopulmonary bypass', 'Bilateral noninvasive cerebral oxygen saturations were monitored over the forehead. The anesthetic and surgical techniques were performed as usual, and no interventions were attempted based on the monitor. Neuropsychological outcome was assessed by the Mini-Mental State Examination (MMSE) and the antisaccadic eye movement test (ASEM).', 'Preoperative baseline values of cerebral oxygen saturation (rSO(2)) were 58.6% +/- 10.2%. Patients with the nadir rSO(2) <35% had significantly higher incidences of postoperative ASEM and MMSE impairments than those with rSO(2) always above 35% (44% and 33% v 12% and 9%, respectively). Patients with areas of rSO(2) <40% for more than 10 minutes . % presented with a significantly higher incidence of postoperative ASEM and MMSE impairments than those with areas of rSO(2) <40% for less than 10 minutes . % (42% and 32% v 13% and 10%, respectively). Patients with postoperative ASEM or MMSE impairment had significantly lower nadir rSO(2) and significantly larger areas of rSO(2) <40%, <45%, and <50% than those with normal postoperative neuropsychological outcome. However, multivariate logistic regression analysis showed that areas of rSO(2) <40% were the only predictor for both postoperative ASEM and MMSE impairments.
Answer: Intraoperative cerebral oxygen desaturation is associated with early postoperative neuropsychological dysfunction in patients undergoing cardiac surgery with cardiopulmonary bypass. However, it remains to be determined whether interventions to maintain adequate cerebral oxygenation may improve neuropsychological outcome.
answer:
Is cerebral oxygen desaturation associated with early postoperative neuropsychological dysfunction in patients undergoing cardiac surgery?