Problem: The top ten best-selling drugs of 2013 totaled $75.6 billion in sales, with the anti-inflammatory drug Humira being the best-selling drug worldwide at $10.7 billion in sales. The second and third best selling were Enbrel and Remicade, respectively. The top three best-selling drugs in the United States in 2013 were Abilify ($6.3 billion,) Nexium ($6 billion) and Humira ($5.4 billion). The best-selling drug ever, Lipitor, averaged $13 billion annually and netted $141 billion total over its lifetime before Pfizer's patent expired in November 2011.
How much money did Lipitor make before the patent expired?
The answer is the following: $141 billion

The second approach to the problem took as its base the notion of class, and defines a set as a class which belongs to other classes, while a proper class is defined as a class which does not belong to other classes. Under the ZermeloFraenkel approach, the axioms impede the construction of a set of all sets which do not belong to themselves. In contrast, under the von Neumann approach, the class of all sets which do not belong to themselves can be constructed, but it is a proper class and not a set.
Under Von Neumann's approach can a class of all sets that do not belong to themselves be constructed?
class of all sets which do not belong to themselves can be constructed, but it is a proper class and not a set.

Input: Somalis
The Xeer legal system also requires a certain amount of specialization of different functions within the legal framework. Thus, one can find odayal (judges), xeer boggeyaal (jurists), guurtiyaal (detectives), garxajiyaal (attorneys), murkhaatiyal (witnesses) and waranle (police officers) to enforce the law.

By what term are witnesses known in the Xeer system?
Output: murkhaatiyal

Input: Article: There are strict limits to how efficiently heat can be converted into work in a cyclic process, e.g. in a heat engine, as described by Carnot's theorem and the second law of thermodynamics. However, some energy transformations can be quite efficient. The direction of transformations in energy (what kind of energy is transformed to what other kind) is often determined by entropy (equal energy spread among all available degrees of freedom) considerations. In practice all energy transformations are permitted on a small scale, but certain larger transformations are not permitted because it is statistically unlikely that energy or matter will randomly move into more concentrated forms or smaller spaces.

Now answer this question: What is often determined by entropy considerations?

Output: direction of transformations in energy

Article: During the 1920s and 1930s, British civil servants and politicians, looking back at the performance of the state during World War I, concluded that there was a need for greater co-ordination between the three Services that made up the armed forces of the United Kingdomthe British Army, the Royal Navy, and the Royal Air Force. The formation of a united ministry of defence was rejected by David Lloyd George's coalition government in 1921; but the Chiefs of Staff Committee was formed in 1923, for the purposes of inter-Service co-ordination. As rearmament became a concern during the 1930s, Stanley Baldwin created the position of Minister for Coordination of Defence. Lord Chatfield held the post until the fall of Neville Chamberlain's government in 1940; his success was limited by his lack of control over the existing Service departments and his limited political influence.

Question: What did David Lloyd George's coalition government reject in 1921?
Ans: The formation of a united ministry of defence

Input: MP3
As sound scholar Jonathan Sterne notes, "An Australian hacker acquired l3enc using a stolen credit card. The hacker then reverse-engineered the software, wrote a new user interface, and redistributed it for free, naming it "thank you Fraunhofer"".

How much did the new released program by the hacker cost?
Output:
free