You will be given a definition of a task first, then some input of the task.
In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength. Citation: Crescenzo-Chaigne B, Barbezange C, van der Werf S (2013) The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression. PLoS ONE 8(11): e81550.
Output:
The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression