Answer the following question given this paragraph: Watch this animation (http://openstaxcollege. org/l/p53_cancer) to learn more about the use of p53 in fighting cancer. Proto-oncogenes are positive cell-cycle regulators. When mutated, proto-oncogenes can become oncogenes and cause cancer. Overexpression of the oncogene can lead to uncontrolled cell growth. This is because oncogenes can alter transcriptional activity, stability, or protein translation of another gene that directly or indirectly controls cell growth. An example of an oncogene involved in cancer is a protein called myc. Myc is a transcription factor that is aberrantly activated in Burkett's Lymphoma, a cancer of the lymph system. Overexpression of myc transforms normal B cells into cancerous cells that continue to grow uncontrollably. High B-cell numbers can result in tumors that can interfere with normal bodily function. Patients with Burkett's lymphoma can develop tumors on their jaw or in their mouth that interfere with the ability to eat. Q: Proto-oncogenes are positive cell-cycle regulators but when mutated, they can become what? A:
Available choices: [I] microbes and cause cancer; [II] bacteria and cause cancer; [III] cultigens and cause cancer; [IV] oncogenes and cause cancer;
[IV]