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Do this by double-clicking the browser's icon shortcut on the desktop. This will prevent the plugin from running with Chrome on startup. Do this by hitting the "X" button in the red box in the upper-right corner of the Google Chrome browser window, and then launching it again through the browser shortcut on your desktop.
Launch your Google Chrome browser. Type in or paste chrome://plugins/ in the address bar at the top of the screen then hit Enter. You will be taken to the plugins window, which lets you configure the plugins that run on Chrome. Locate the plugin you want to disable and click on the "Disable" button beside it. Restart Chrome.