In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Absorption of neutral amino acids across the luminal membrane of intestinal enterocytes is mediated by the broad neutral amino acid transporter B 0 AT1 (SLC6A19). Its intestinal expression depends on co-expression of the membrane-anchored peptidase angiotensin converting enzyme 2 (ACE2) and is additionally enhanced by aminopeptidase N (CD13). We investigated in this study the expression of B 0 AT1 and its auxiliary peptidases as well as its transport function along the rat small intestine. Additionally, we tested its possible shortand long-term regulation by dietary proteins and amino acids. We showed by immunofluorescence that B 0 AT1, ACE2 and CD13 co-localize on the luminal membrane of small intestinal villi and by Western blotting that their protein expression increases in distal direction. Furthermore, we observed an elevated transport activity of the neutral amino acid L-isoleucine during the nocturnal active phase compared to the inactive one. Gastric emptying was delayed by intragastric application of an amino acid cocktail but we observed no acute dietary regulation of B 0 AT1 protein expression and L-isoleucine transport. Investigation of the chronic dietary regulation of B 0 AT1, ACE2 and CD13 by different diets revealed an increased B 0 AT1 protein expression under amino acid-supplemented diet in the proximal section but not in the distal one and for ACE2 protein expression a reverse localization of the effect. Dietary regulation for CD13 protein expression was not as distinct as for the two other proteins. Ring uptake experiments showed a tendency for increased L-isoleucine uptake under amino acid-supplemented diet and in vivo L-isoleucine absorption was more efficient under high protein and amino acid-supplemented diet. Additionally, plasma levels of branched-chain amino acids were elevated under high protein and amino acid diet. Taken together, our experiments did not reveal an acute amino acid-induced regulation of B 0 AT1 but revealed a chronic dietary adaptation mainly restricted to the proximal segment of the small intestine.
Title: Expression and regulation of the neutral amino acid transporter B 0 AT1 in rat small intestine

A: False
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Q: Paragraph: Background: The burden of Hepatitis C virus (HCV) has become more and more considerable in China. A macroscopic spatial analysis of HCV infection that can provide scientific information for further intervention and disease control is lacking. Methods: All geo-referenced HCV cases that had been recorded by the China Information System for Disease Control and Prevention (CISDCP) during 2005-2011 were included in the study. In order to learn about the changes of demographic characteristics and geographic distribution, trend test and spatial analysis were conducted to reflect the changing pattern of HCV infection. Results: Over 770,000 identified HCV infection cases had specific geographic information during the study period (2005)(2006)(2007)(2008)(2009)(2010)(2011). Ratios of gender (Male/Female, Z-value = 218.53, P,0.001), age group (#30 years old/$31 years old, Z-value = 2 51.03, P,0.001) and diagnosis type (Clinical diagnosis/Laboratory diagnosis, Z-value = 2130.47, P,0.001) declined. HCV infection was not distributed randomly. Provinces Henan, Guangdong, Guangxi, Xinjiang, and Jilin reported more than 40,000 HCV infections during 2005 to 2011, accounting for 43.91% of all cases. The strength of cluster of disease was increasing in China during the study period. Overall, 11 provinces had once been detected as hotspots during 7 years, most of which were located in the central or border parts of China. Tibet, Qinghai, Jiangxi were the regions that had coldspots. The number of clustering of HCV infection among older adults increased in recent years. Specific interventions and prevention programs targeting at main HCV epidemic areas are urgently in need in mainland China.
Title: Spatial Analysis on Hepatitis C Virus Infection in Mainland China: From 2005 to 2011

A: False
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Q: Paragraph: Background: Italy is bearing the brunt of the COVID-19 pandemic, as the death toll there has already surpassed that in Wuhan, the city in China where the coronavirus emerged in December 2019. Here we employ statistical methods to assess the severity of COVID-19 pandemic across different regions of Italy. We manually retrieved the daily cumulative numbers of laboratory-confirmed cases and deaths attributed to COVID-19 stratified by region in Italy from March 2, 2020 to March 28, 2020. We estimated both the crude and time-delay adjusted case fatality ratio across five geographic regions of Italy: Northwest, Northeast, Center, South and Island. : The Northwest that includes Lombardy exhibited the highest time-delay-adjusted CFR at 31.4%% [95% credible interval: 30.8, 32.1%] followed by the Northeast (20.3%) [95% CrI: 19.4, 21.1], the Center region (16.5%) [95% CrI: 15.4, 17.7] and the South region (16.8%) [95% CrI: 15.0, 18.7]. The Island region has exhibited the lowest CFR (11.8%) [95% CrI: 9.0, 14.8]. Conclusion: Italy is experiencing one of the highest CFR from the COVID-19 pandemic in the world. Time delay adjusted CFR in all the regions in Italy except the Island region were higher than that estimated for Wuhan, China. The CFR in Northwest Italy is 2.5-fold higher than that in Wuhan. Our finding reflects the need of urgent medical support in the Northwest region and the appropriate planning and supplies procurement in other regions of Italy with . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity. is the (which was not peer-reviewed) The copyright holder for this preprint .
Title: Title: Spatial variability in the risk of death from COVID-19 in Italy, 2020

A:
False
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