Question: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:
Is there an answer to this question: How many are in the pipelin to fight GNB?

Answer: seven

Question: Large scale climatic changes, as have been experienced in the past, are expected to have an effect on the timing of migration. Studies have shown a variety of effects including timing changes in migration, breeding as well as population variations.
Is there an answer to this question: What have studies shown regarding climate change?

Answer: timing changes in migration

Question: On 9 February 2014, Swiss voters narrowly approved by 50.3% a ballot initiative launched by the national conservative Swiss People's Party (SVP/UDC) to restrict immigration, and thus reintroducing a quota system on the influx of foreigners. This initiative was mostly backed by rural (57.6% approvals), suburban (51.2% approvals), and isolated cities (51.3% approvals) of Switzerland as well as by a strong majority (69.2% approval) in the canton of Ticino, while metropolitan centres (58.5% rejection) and the French-speaking part (58.5% rejection) of Switzerland rather rejected it. Some news commentators claim that this proposal de facto contradicts the bilateral agreements on the free movement of persons from these respective countries.
Is there an answer to this question: Which centres of Switzerland mostly rejected the quota system for foreigners?

Answer: metropolitan

Question: The political situation in England rapidly began to deteriorate. Longchamp refused to work with Puiset and became unpopular with the English nobility and clergy. John exploited this unpopularity to set himself up as an alternative ruler with his own royal court, complete with his own justiciar, chancellor and other royal posts, and was happy to be portrayed as an alternative regent, and possibly the next king. Armed conflict broke out between John and Longchamp, and by October 1191 Longchamp was isolated in the Tower of London with John in control of the city of London, thanks to promises John had made to the citizens in return for recognition as Richard's heir presumptive. At this point Walter of Coutances, the Archbishop of Rouen, returned to England, having been sent by Richard to restore order. John's position was undermined by Walter's relative popularity and by the news that Richard had married whilst in Cyprus, which presented the possibility that Richard would have legitimate children and heirs.
Is there an answer to this question: Who refused to work with Puiset?

Answer:
Longchamp