Serum ionized calcium determination is often normal in patients with chronic renal failure and high in patients with primary hyperparathyroidism or hypercalcemia that is associated with a malignancy.

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Serumionizedcalciumdeterminationisoftennormalinpatientswithchronicrenalfailureandhighinpatientswithprimaryhyperparathyroidismorhypercalcemiathatisassociatedwithamalignancy.