In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.

An analysis of skeletal development in osteoblast- and chondrocyte-specific Runx2 knockout mice.
Runx2

Overview of monoclonal antibodies and small molecules targeting the epidermal growth factor receptor pathway in colorectal cancer.
epidermal growth factor receptor

Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.
AMP-activated protein kinase