Detailed Instructions: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Problem:Question: The binding of O2 to hemoglobin:
Options: <1> Follow a hyperbolic kinetics. <2> It favors the transition from Fe2 + to Fe3 + in the heme group of the protein. <3> Induces the deprotonation of the protein. <4> It is facilitated in the presence of 2,3bisphosphoglycerate. <5> It is carried out through a covalent interaction with Fe3 +.
Solution:
3