In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example input: Question: A 13-year-old girl is operated on due to Hirschsprung illness at 3 months of age. Which of the following tumors is more likely to be present?
Options: <1> Abdominal neuroblastoma <2> Wilms tumor <3> Mesoblastic nephroma <4> Familial thyroid medullary carcinoma.
Example output: 2
Example explanation: The answer to the given question should be a tumor, therefore Wilms tumor is the correct answer for the given question.
Q: Question: Regarding the designs of clinical trials to demonstrate efficacy of antidepressants, which of the following is FALSE?
Options: <1> The inclusion in the design of clinical trials of secondary safety variables is important in order to establish the therapeutic location of the drugs studied. <2> In studies of depression it is not considered ethical to use a control group with placebo. <3> The efficacy of antidepressants is measured by the proportion of subjects with a predetermined percentage reduction in specific depression scales, such as Hamilton's or Beck's. <4> Due to the great variability of the response between one study and another, comparisons between active drugs with a noninferiority design do not allow to conclude efficacy in a robust way. <5> Although clinical improvement can be seen in one or two weeks, it usually takes 4 weeks of follow-up in clinical trials to establish significant differences.
A:
2