instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
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Paragraph: For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution. The information provided by these structures, which covers many important aspects of the viral life cycle such as cell-receptor recognition, viral entry, nucleic acid transfer and genome replication, has extensively enriched our vision of the virus world. Many of the structures available correspond to potential targets for antiviral drugs against important human pathogens. This article provides an overview of the current knowledge of different structural aspects of the above-mentioned processes.
Title: BIOLOGYjMEDICINE Viruses and viral proteins
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True

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Paragraph: Background 3 In silico bacterial, viral, and human truth datasets were generated to evaluate available metagenomics 4 algorithms. Sequenced datasets include background organisms, creating ambiguity in the true 5 source organism for each read. Bacterial and viral datasets were created with even and staggered 6 coverage to evaluate organism identification, read mapping, and gene identification capabilities of 7 available algorithms. These truth datasets are provided as a resource for the development and 8 refinement of metagenomic algorithms. Algorithm performance on these truth datasets can inform 9 decision makers on strengths and weaknesses of available algorithms and how the results may be best 10 leveraged for bacterial and viral organism identification and characterization. 11 12 Source organisms were selected to mirror communities described in the Human Microbiome Project as 13 well as the emerging pathogens listed by the National Institute of Allergy and Infectious Diseases. The 14 six in silico datasets were used to evaluate the performance of six leading metagenomics algorithms: 15 MetaScope, Kraken, LMAT, MetaPhlAn, MetaCV, and MetaPhyler. 16 Results Algorithms were evaluated on runtime, true positive organisms identified to the genus and species 19 levels, false positive organisms identified to genus and species level, read mapping, relative abundance 20 estimation, and gene calling. No algorithm out performed the others in all categories, and the 21 algorithm or algorithms of choice strongly depends on analysis goals. MetaPhlAn excels for bacteria 22 and LMAT for viruses. The algorithms were ranked by overall performance using a normalized 23 weighted sum of the above metrics, and MetaScope emerged as the overall winner, followed by Kraken 24 and LMAT. 25 Conclusions 27 Simulated FASTQ datasets with well--characterized truth data about microbial community composition 28 reveal numerous insights about the relative strengths and weaknesses of the metagenomics algorithms 29 evaluated. The simulated datasets are available to download from the Sequence Read Archive 30 (SRP062063). 31 32
Title: Evaluating performance of metagenomic characterization algorithms using in silico datasets generated with FASTQSim
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False

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Paragraph: From an aqueous decoction of the traditional Chinese medicine "ban lan gen" (the Isatis indigotica root), an antiviral natural product CI -39 was isolated as an NNRTI (non-nucleoside reverse transcriptase inhibitor) (EC 50 3.40 mM). Its novel structure was determined as methyl (1-methoxy-1H-indol-3-yl) acetamidobenzoate by spectroscopic data and confirmed by single crystal X-ray diffraction. Through synthesis and structure-activity relationship (SAR) investigation of CI -39 and 57 new derivatives (24 with EC 50 values of 0.06e8.55 mM), two optimized derivatives 10f and 10i (EC 50 : 0.06 mM and 0.06 mM) having activity comparable to that of NVP (EC 50 0.03 mM) were obtained. Further evaluation verified that 10f and 10i were RT DNA polymerase inhibitors and exhibited better activities and drug resistance folds compared to NVP against seven NNRTI-resistant strains carrying different mutations. Especially, 10i (EC 50 0.43 mM) was more active to the L100I/K103N double-mutant strain as compared to both NVP (EC 50 0.76 mM) and EFV (EC 50 1.08 mM). The molecular docking demonstrated a possible binding pattern between 10i and RT and revealed activity mechanism of 10i against the NNRTI-resistant strains. a Chemical shift values (d) were measured at 500 MHz for 1 H and at 125 MHz for 13 C, respectively. Proton coupling constants (J) in Hz are given in parentheses. The assignments were based on DEPT, 1 He 1 H COSY, HSQC, and HMBC experiments. C. Xu et al.
Title: Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root
answer:
False