TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Imatinib is one of the most recent medications used for the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). It is an orally administered protein-tyrosine kinase inhibitor, an enzyme which is produced by BCR-ABL fusion which results from translocation of 9:22 chromosome (Philadelphia chromosome). Imatinib blocks proliferation and induces apoptosis of BCR-ABL-expression in CML. Many side effects produced by imatinib have been documented but its induction of hepatotoxcity has been rarely reported. Only a few cases so far have been reported in the literature and almost all were in females. We describe another case of hepatotoxicity due to imatinib in a 17-year old female with clinical, laboratory and histopathological changes. The case described here suggests that imatinib may also induce immune hepatitis, in some patients.

SOLUTION: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

PROBLEM: Contrary to earlier beliefs, viruses are not the smallest causative agents of infectious diseases. Single-stranded RNAs as small as 246 nucleotides exist in certain higher plants and cause more than a dozen crop diseases. These RNAs have been termed viroids. Despite their extremely limited information content, viroids replicate autonomously in susceptible cells--that is, they do not require helper functions from simultaneously replicating conventional viruses. Viroids are covalently closed circular molecules with a characteristic rodlike secondary structure in which short helical regions are interrupted by internal and bulge loops. Viroids are not translated; they are replicated by a host enzyme (or enzymes) (probably RNA polymerase II) via oligomeric RNA intermediates by a rolling circle mechanism. Viroidlike satellite RNAs resemble viroids in size and molecular structure, but are found within the capsids of specific helper viruses on which they depend for their own replication. These RNAs are of great interest to molecular biology for at least two reasons: 1) they are the smallest and simplest replicating molecules known, and 2) they may represent living fossils of precellular evolution in a hypothetical RNA world.

SOLUTION: Which are the smallest known subviral pathogens of plants?

PROBLEM: Lombard Street (San Francisco, USA) Known as "the world's most-crooked street," Lombard Street was first built in 1922 to reduce the hill's natural 27 % grade ,which was too steep for most vehicles. Lombard Street owns the record as the street with the most switchbacks in a single block. With eight steep and sharp turns, Lombard Street looks like a giant dizzy snake lying on the road. This famous street in San Francisco is known as the most-challenging street of all. Parliament Street (Exeter, England) This street in England is over a hundred years old today, but what makes it as an urban wonder is not its age but its unbelievable narrow size. Usually, a street is where a vehicle can conveniently pass, but that will never happen in the Parliament Street, as the street measures just 25 inches wide which is just enough for a ly medium-built person to pass. King Fahd's Fountain (Jeddah, Saudi Arabia) The fountain was donated to the city by King Fahd. Being the world's tallest fountain, it deserves to be an urban wonder. It was constructed between 1980 and 1983. This fountain shoots water in an incredible 1023-foot (312m) height which is greater than the height of the Eifel Tower. Because of its seemingly unreachable height, the waters of the King Fahd's Fountain can be sighted even if the visitors are miles apart. Damanhur Temple (Northern Alps of Italy) The underground of the modest homes of Italy's northern Alps is where a massive, richly -decorated temple is found. The Damanhur Temple was secretly constructed in the 1970s. Decorated with impressive murals and vividly-color1ed stain glass, the temple was once seized by the Italian government due to illegalities. After some time, it was returned to Oberto Airaudi, the builder and founder of Damanhur.

SOLUTION:
What is King Fahd's Fountain most famous for?