In 1853, Victoria gave birth to her eighth child, Leopold, with the aid of the new anaesthetic, chloroform. Victoria was so impressed by the relief it gave from the pain of childbirth that she used it again in 1857 at the birth of her ninth and final child, Beatrice, despite opposition from members of the clergy, who considered it against biblical teaching, and members of the medical profession, who thought it dangerous. Victoria may have suffered from post-natal depression after many of her pregnancies. Letters from Albert to Victoria intermittently complain of her loss of self-control. For example, about a month after Leopold's birth Albert complained in a letter to Victoria about her "continuance of hysterics" over a "miserable trifle".
What did Albert complain about in letters to Victoria after the birth of her children?
loss of self-control

There are very few existing mosaics from the Komnenian period but this paucity must be due to accidents of survival and gives a misleading impression. The only surviving 12th-century mosaic work in Constantinople is a panel in Hagia Sophia depicting Emperor John II and Empress Eirene with the Theotokos (112234). The empress with her long braided hair and rosy cheeks is especially capturing. It must be a lifelike portrayal because Eirene was really a redhead as her original Hungarian name, Piroska shows. The adjacent portrait of Emperor Alexios I Komnenos on a pier (from 1122) is similarly personal. The imperial mausoleum of the Komnenos dynasty, the Pantokrator Monastery was certainly decorated with great mosaics but these were later destroyed. The lack of Komnenian mosaics outside the capital is even more apparent. There is only a "Communion of the Apostles" in the apse of the cathedral of Serres.
The only surviving mosaic from the Komnenos dynasty outside Constantinople is in what church?
the cathedral of Serres

In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co. discovered and developed chlorothiazide, which remains the most widely used antihypertensive drug today. This development was associated with a substantial decline in the mortality rate among people with hypertension. The inventors were recognized by a Public Health Lasker Award in 1975 for "the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension".
In what year was hydralazine discovered?
1952