In this task, you are given a question and answer options for that question. Using this information, you have to classify each text into different topics: medicine, nursery, psychology, chemistry, pharmacology, biology.
Q: Question: The hepatic clearance of a drug, mainly eliminated by metabolism, which has a high degree of hepatic extraction and a high binding to plasma proteins:
Options: <0> It is significantly influenced by the hepatic blood flow. <1> It is significantly influenced by changes in the degree of plasma protein binding. <2> It is significantly influenced both by hepatic blood flow and by changes in the degree of plasma protein binding. <3> It will not be influenced by the hepatic blood flow or by changes in the degree of binding to plasma proteins. <4> It will depend on the absolute bioavailability of the drug.
A:
pharmacology