Premise:
"The first European to see the Mississippi was the Spanish Conquistador Hernando de Soto, brother-in-law of Balboa and the discoverer of the Pacific."
Hypothesis: Hernando de Soto wrote back to Spain about the majesty of the Mississippi.

it is not possible to tell

Premise:
"No, I thank you, madame. "
Hypothesis: No, Thank YOU.

yes

Premise:
"But he is funny. "
Hypothesis: He has a good sense of humor.
yes