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Historically, in North America, one of the most economically destructive pests in cotton production has been the boll weevil. Due to the US Department of Agriculture's highly successful Boll Weevil Eradication Program (BWEP), this pest has been eliminated from cotton in most of the United States. This program, along with the introduction of genetically engineered Bt cotton (which contains a bacterial gene that codes for a plant-produced protein that is toxic to a number of pests such as cotton bollworm and pink bollworm), has allowed a reduction in the use of synthetic insecticides.

What program has effectively eliminated the boll weevil in the US?
Boll Weevil Eradication Program