In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Ex Input:
Question: In disorders related to substance use, what is physical dependence?
Options: <1> In a physical process of short duration. <2> In an intense sense of dissatisfaction for not being able to consume the substances. <3> In the action of consuming drugs producing a state of intoxication with psychoactive effect. <4> In a series of physical and psychic changes that take place after the administration of a substance. <5> In a state of physical adaptation manifested by intense physical disturbances when the administration of the drug is interrupted.

Ex Output:
5

Ex Input:
Question: Liquid chromatography in normal phase:
Options: <1> It uses a column with apolar groups that interact with the apolar part of the analytes differentially. <2> It is a mode of operation that employs a polar stationary phase with a low polarity mobile phase. <3> It uses highly polar mobile phases such as alkanes or chloroalkanes. <4> It is a mode of operation that employs a non-polar surface with a mixed aqueous / organic mobile phase. <5> It uses stationary phases with a large number of hydrophobic alkyl ligands.

Ex Output:
2

Ex Input:
Question: The gastrointestinal system releases a peptide hormone that increases during fasting and decreases after ingestion, called:
Options: <1> Leptin <2> Cholecystokinin <3> Ghrelin <4> Insulin. <5> Glycogen

Ex Output:
3