Detailed Instructions: In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
Q: Paragraph: A CTL antigenic site located between residues 273 and 291 of the E1 envelope protein of RV was identified by 51Cr_release assays employing SPs. Two E 1specific CTL clones were examined for immune recognition of RV wild-type and attenuated vaccine strains and recombinant E1 protein. The exact sequence (273-284) recognized by both clones was delineated by using truncated and overlapping SPs covering these residues. The defined T-cell site overlapped almost completely with a virus neutralizing antibody-binding site previously identified with mouse monoclonal and human antibodies. A series of single aa-substituted SP analogues of E1(273-284) was used to define residues critical for T-cell recognition. Using EBV-BL displaying different HLA-DR haplotypes and -DR4 subtypes as targets to determine MHC class II restriction elements, immune recognition by both T-cell clones was shown to be associated with HLA-DR4. Three HLA-DR4 subtypes (DR4Dw13A, DR4Dw13B, and DR4KT2) sharing a common residue, glutamic acid at position 74 in their ~ 1 chains, were able to present SP E1(273-284) to the T-cell clones.
Title: Analysis of Overlapping T-and B-Cell Antigenic Sites on Rubella Virus E1 Envelope Protein Influence of HLA-DR4 Polymorphism on T-Cell Clonal Recognition
A:
False