Detailed Instructions: Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).
Problem:Abstract: When bovine parathyroid cells in culture are exposed to the active vitamin D metabolite 1,25(OH)2D3, a significant decrease in the steady-state levels of pre-proparathyroid hormone (pre-proPTH) mRNA occurs. The possibility that the fall in specific mRNA is due to a decrease in rate of transcription of the PTH gene was examined in this study. In the presence of 1,25(OH)2D3, there was a rapid and steady decline in PTH gene transcription rate which fell to a minimum of 10-15% of control at 24 h. The effect was observed at physiological levels (10(-11)M) and was also fully reversible.
Which is the apt title for the abstract? option1: Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene. option2: Primary spinal melanoma.
Solution:
Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene.