Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Input: Consider Input: Microscopes were first developed in the early 1600s by eyeglass makers.

Output: Microscopes were first developed in the early 1600s by this trade?

Input: Consider Input: Terrestrial biomes are associated with land, while aquatic ones are associated with water.

Output: Terrestrial biomes are associated with land, while aquatic ones are associated with what?

Input: Consider Input: Electrons always result in an anion that is larger than the parent atom.
Output: Electrons always result in what?