The Revolutionary War soldier Nathan Hale (Yale 1773) was the prototype of the Yale ideal in the early 19th century: a manly yet aristocratic scholar, equally well-versed in knowledge and sports, and a patriot who "regretted" that he "had but one life to lose" for his country. Western painter Frederic Remington (Yale 1900) was an artist whose heroes gloried in combat and tests of strength in the Wild West. The fictional, turn-of-the-20th-century Yale man Frank Merriwell embodied the heroic ideal without racial prejudice, and his fictional successor Frank Stover in the novel Stover at Yale (1911) questioned the business mentality that had become prevalent at the school. Increasingly the students turned to athletic stars as their heroes, especially since winning the big game became the goal of the student body, and the alumni, as well as the team itself.
What profession did Frederic Remington hold?
artist

The body's capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child's immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active.
What are the four factors that determine how the body reacts to an antigen?
person's age, antigen type, maternal factors and the area

In 1516, William IV, Duke of Bavaria, adopted the Reinheitsgebot (purity law), perhaps the oldest food-quality regulation still in use in the 21st century, according to which the only allowed ingredients of beer are water, hops and barley-malt. Beer produced before the Industrial Revolution continued to be made and sold on a domestic scale, although by the 7th century AD, beer was also being produced and sold by European monasteries. During the Industrial Revolution, the production of beer moved from artisanal manufacture to industrial manufacture, and domestic manufacture ceased to be significant by the end of the 19th century. The development of hydrometers and thermometers changed brewing by allowing the brewer more control of the process and greater knowledge of the results.
Who was the Duke of Bavaria in 1516?
William IV