In this task, you're given a question, along with a context passage. The passage will not have a direct answer to the question, but can include some information and a clue for the answer. Assuming you can only obtain information about one entity in the passage, your job is to determine whether information from the passage can be used to answer the question. Indicate your choice as 'a' for Yes or 'b' for No.

Question: When was the Great Fire of London?
Passage:Bermondsey was historically a rural parish on the outskirts of London until the 17th century when the area began to be developed as a wealthy suburb following the Great Fire of London. By the 19th century, the once affluent parts of Bermondsey had experienced a serious decline, and became the site of notorious slums with the arrival of industrialisation, docks and migrant housing, especially along the riverside. The most notorious of the slums was known as Jacob's Island, with the boundary approximately the confluence of the Thames and subterranean River Neckinger, at St Saviour's Dock across from Shad Thames, to the west, a tidal ditch just west of George Row to the east, and another tidal ditch just north of London Street (now Wolseley Street) to the south. It was a particularly squalid rookery, and described as "The very capital of cholera" and "The Venice of drains" by The Morning Chronicle in 1849.

b

Question: What team had the worst record in the Latvian Higher League the year that Karlsons was the top scorer with 26 goals? Passage:As a youth player Karlsons played for his local club FK Liepajas Metalurgs, being taken to the first team in 1998, at the age of 17. He spent the next six seasons with the club, becoming the second top scorer of the Latvian Higher League in 2003 with 26 goals, completing two hat-tricks during the season. All in all he played 96 matches for his local club, scoring 40 goals. After these bright appearances he had impressed clubs abroad, and in January 2004 Karlsons went on a month-long trial with the Russian Premier League club Shinnik Yaroslavl. Afterwards he signed a three-year contract with them. However, his spell there wasn't as successful as expected and was very short. After just one season, during which he played only 8 league matches without scoring goals, Karlsons returned to the Latvian Higher League, signing with the newly promoted, ambitious club Venta Kuldiga in 2005. However, the club struggled financially and after just five matches had to let some of their players go, including Karlsons, who returned to his hometown club, Liepajas Metalurgs later that year. He spent the next three seasons there, once again showing great performance. He scored a hat-trick in the 2005 season, and he also scored in the Latvian Cup final on 25 September 2005, which Metalurgs lost 21 to Venta Kuldiga. Another hat-trick came in the 2006 season, which Karlsons finished as the second top scorer with 14 goals under his belt. In the Latvian Cup he scored a hat-trick in the 61 semi-final victory over Dizvanagi Rezekne and then scored in the final, which the club won 21 over Skonto Riga. In December 2006 Karlsons was named the runner-up of the Latvian Player of the Year Award by the Latvian Football Federation behind the winner Aleksandrs Kolinko, who that time was the first-choice keeper for Rubin Kazan in the Russian Premier League. His contract with Metalurgs expired in July 2007 and it was not renewed. Player was then linked with the English Championship club Bristol City, before going on trial with Southampton. In January 2008 he had a two-day trial with Wolverhampton Wanderers. Karlsons then had trials in the Netherlands with Zwolle and De Graafschap,

a

Question: When was the discovery of the base in DNA that is involved in the formation of 8-oxoguanine? Passage:The role of the deoxyriboside form of 8-oxoguanine, 8-oxo-2'-deoxyguanosine (abbreviated 8-oxo-dG or 8-OHdG) in cancer and aging also applies to 8-oxoguanine. Oxoguanine glycosylase is employed in the removal of 8-oxoguanine from DNA by the process of base excision repair. As described in oxoguanine glycosylase, deficient expression of this enzyme causes 8-oxoguanine to accumulate in DNA. This accumulation may then lead upon replication of DNA to mutations including some that contribute to carcinogenesis. 8-oxoguanine is usually formed by the interaction of reactive oxygen species (ROS) with the guanine base in DNA under conditions of oxidative stress; as noted in the article about them, such species may have a role in aging and male infertility, and 8-oxoguanine can be used to measure such stress.
b