Question: Extract the answer to the question from the following context. Question: Where does the FDA have jurisdiction? Context: In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.
Answer: In the United States

Question: Extract the answer to the question from the following context. Question: Who succeeded the man referred to as "the Great"? Context: The last ruler to maintain united state was Mstislav the Great. After his death in 1132 the Kievan Rus' fell into recession and a rapid decline, and Mstislav's successor Yaropolk II of Kiev instead of focussing on the external threat of the Cumans was embroiled in conflicts with the growing power of the Novgorod Republic. In 1169, as the Kievan Rus' state was full of internal conflict, Andrei Bogolyubsky of Vladimir sacked the city of Kiev. The sack of the city fundamentally changed the perception of Kiev and was evidence of the fragmentation of the Kievan Rus'. By the end of the 12th century, the Kievan state became even further fragmented and had been divided into roughly twelve different principalities.
Answer: Yaropolk II of Kiev

Question: Extract the answer to the question from the following context. Question: What happened to 16 2/3 rpm speed at last? Context: Some recordings, such as books for the blind, were pressed at 16 23 rpm. Prestige Records released jazz records in this format in the late 1950s; for example, two of their Miles Davis albums were paired together in this format. Peter Goldmark, the man who developed the 33 13 rpm record, developed the Highway Hi-Fi 16 23 rpm record to be played in Chrysler automobiles, but poor performance of the system and weak implementation by Chrysler and Columbia led to the demise of the 16 23 rpm records. Subsequently, the 16 23 rpm speed was used for narrated publications for the blind and visually impaired, and were never widely commercially available, although it was common to see new turntable models with a 16 rpm speed setting produced as late as the 1970s.
Answer:
never widely commercially available