instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Is a gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity associated with familial Inappropriate Sinus Tachycardia?
Answer: This is the first report of a gain-of-function HCN4 mutation associated with IST through increased sensitivity to cAMP-dependent activation.
answer:
yes

question:
Question: Is transgene-induced gene silencing affected by a change in ploidy level?
Answer: Our results in A. thaliana indicated that there is no effect of ploidy level on transgene-induced post-transcriptional gene silencing. Our findings that post-transcriptional mechanisms were equally effective in diploids and tetraploids supports the use of transgene-driven post-transcriptional gene silencing as a useful mechanism to modify gene expression in polyploid species.
answer:
no

question:
Question: Does isometric strength assessment , part I : static testing accurately predict dynamic lifting capacity?
Answer: The Static Leg Lift, Static Arm Lift and Static Back (Torso) Lift are not appropriate for making predictions relative to dynamic lifting capacity. Given the likely degree of error in such predictions, and in light of potential safety concerns as reported by previous investigators, employers, clinicians and risk managers now have substantial objective evidence to call such testing into question.
answer:
no