instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
A novel Ca2+/calmodulin-dependent protein kinase II (CaM Kinase II) inhibitor, KN-93 potently inhibits gastric acid secretion from parietal cells. As previously reported (1), treatment of parietal cells with a selective inhibitor of CaM kinase II, KN-62 resulted in the inhibition of cholinergic-stimulated rabbit parietal cell secretion, whereas it failed to inhibit the histamine and forskolin response. In contrast effects of carbachol, histamine and forskolin were significantly inhibited by KN-93 with an IC50 of 0.15, 0.3 and 1 microM, respectively; these effects occurred without any changes in intracellular cyclic AMP and Ca2+ levels. In the present study we investigated the mechanism by which KN-93 acts upon the acid-secreting machinery of gastric parietal cells. Neither redistribution of the proton pump activity nor the morphological transformation were affected by KN-93. The drug only weakly inhibited the H+, K(+)-ATPase activity but strongly dissipated the proton gradient formed in the gastric membrane vesicles and reduced the volume of luminal space. Thus KN-93 acts at pH gradient formation whereas KN-62 acts only at CaM Kinase II.
answer:
Which kinase is inhibited by the small molecule KN-93?

question:
The DRG Class 99.19 engines were metre gauge, ten-coupled, superheated, steam locomotives that were employed in the southwestern German state of Wurttemberg from 1927.
answer:
What was the year that DRG Class 99.19 entered service?

question:
Weathering is the process that changes solid rock into sediments. Sediments were described in the chapter "Ma- terials of Earths Crust." With weathering, rock is disintegrated. It breaks into pieces. Once these sediments are separated from the rocks, erosion is the process that moves the sediments. While plate tectonics forces work to build huge mountains and other landscapes, the forces of weathering gradually wear those rocks and landscapes away. Together with erosion, tall mountains turn into hills and even plains. The Appalachian Mountains along the east coast of North America were once as tall as the Himalayas. No human being can watch for millions of years as mountains are built, nor can anyone watch as those same mountains gradually are worn away. But imagine a new sidewalk or road. The new road is smooth and even. Over hundreds of years, it will completely disappear, but what happens over one year? What changes would you see? (Figure 1.1). What forces of weathering wear down that road, or rocks or mountains over time? A once smooth road surface has cracks and fractures, plus a large pothole. Click image to the left or use the URL below. URL:
answer:
the process that changes solid rock into sediments.