Jones was born in Toulminville, Alabama, on April 10, 1968. His father was a professional baseball player for the Philadelphia Phillies. He moved to Mauldin, South Carolina, when he was a teen and graduated from Mauldin High School in 1985. One of his early acting experiences involved playing a werewolf in a haunted house to help raise money for the junior/senior prom.

Aside from MADtv, Jones made many other television appearances. Perhaps his most popular and enduring television appearance was not in the form of a sitcom or television drama, but rather in a series of humorous commercials for a soda company. In 2000, Jones became the spokesperson for 7 Up and he gained wide recognition. This exposure led to a plethora of opportunities for Jones. First, he hosted an HBO First Look special in 2000 and then, in 2003, Jones was given his own late night talk show on FX called The Orlando Jones Show. Although his talk show was short lived, Jones continued to make additional television appearances. In 2003, he appeared on The Bernie Mac Show and on Girlfriends. In 2006, Jones decided to return to television as one of the lead characters of ABC's crime drama The Evidence, as Cayman Bishop. He has also appeared in two episodes of Everybody Hates Chris, the first in 2007 as Chris's substitute teacher and the second in 2008 as Clint Huckstable, an allusion to the character Cliff Huxtable played by Bill Cosby on The Cosby Show. In 2008, he appeared as Harold Wilcox, a violent veteran with PTSD, on New Amsterdam. In the first season of the show, Jones also starred on Nick Cannon's Wild 'N Out. Jones was the first guest star on the show. Jones was the co-host of ABC's Crash Course (which was canceled after 4 episodes). On November 16, 2009, it was announced on TV Guide that Orlando has been cast as Marcus Foreman, Eric Foreman's brother on House, appearing in the season six episode "Moving the Chains". In 2013, he was hired as a principal actor in the FOX television series Sleepy Hollow. The freshman drama opened to FOX's highest fall drama premiere numbers since the premiere of '24' in 2001. In 2016, Jones was cast as Mr. Nancy in American Gods.

Answer the following question by taking a quote from the article: What were some of the other projects Jones worked on?
a series of humorous commercials for a soda company. In 2000, Jones became the spokesperson for 7 Up and he gained wide recognition.