Given the task definition and input, reply with output. In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Type I interferon is important in anti-viral responses and in coordinating the innate immune response. Here we explore the use of interferon- to adjuvant the response to a rabies virus (RV) vaccine vector expressing both HIV-1 Gag and IFN-. Viral load and immune responses of immunized mice were analyzed over time. Our results indicate that the RV expressing IFN- (IFN(+)) is highly attenuated when compared to control RV and demonstrate that the expression of IFN- reduces viral replication approximately 100-fold. Despite the decrease in replication, those mice immunized with the IFN(+) RV had a significantly greater number of activated CD8+ T cells. The increased activation of CD8 + T cells was dependent on IFN- signaling, as we saw no difference following infection of IFNAR / mice. Although mice immunized with IFN(+) have a greater primary immune response than controls, immunized mice that were challenged with vaccinia expressing Gag had no significant difference in the number or functionality of CD8+ T cells. The increased CD8+ T cell activation in the presence of IFN-, even with greatly reduced viral replication, indicates the beneficial effect of IFN- for the host.
Interferon- expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity