TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is the G-308A variant of the Tumor Necrosis Factor-alpha ( TNF-alpha ) gene associated with obesity , insulin resistance and body fat distribution?
Answer: Our study did not detect any significant association of the G-308A TNFalpha polymorphism with obesity or with its clinical and metabolic abnormalities in this population. Our data suggests that, in our population, the G-308A TNFalpha polymorphism is unlikely to play a major role in the pathogenesis of these conditions.

SOLUTION: no

PROBLEM: Question: Is assessment of joint space narrowing with conventional standing antero-posterior radiographs : relief in mild-to-moderate pain a confounder in recent osteoarthritis structure-modifying drug trials?
Answer: Knee pain relief did not bias the report of a structure-modifying effect of glucosamine sulfate in two recent long-term trials, possibly due to the mild-to-moderate patient characteristics. Consensus deliverables should acknowledge that the potential limitations of conventional standing antero-posterior radiographs should not be overestimated since they may not apply to all patient populations and to all studies using this gold standard technique.

SOLUTION: no

PROBLEM: Question: Do histone deacetylase and GATA-binding factor 6 regulate arterial remodeling in angiotensin II-induced hypertension?
Answer: These results suggest that class II HDAC inhibition attenuates hypertension by negatively regulating VSMC hypertrophy and hyperplasia via the CaMKII/protein kinase D1/HDAC4/GATA6 pathway.

SOLUTION:
yes