instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Unlike local transmission of pandemic influenza A (H1N1-2009), which was frequently driven by school children, most cases identified in long-distance intranational and international travelers have been adults. The present study examines the relationship between the probability of temporary extinction and the age-dependent next-generation matrix, focusing on the impact of assortativity. Preferred mixing captures as a good approximation the assortativity of a heterogeneously mixing population. We show that the contribution of a nonmaintenance host (i.e., a host type which cannot sustain transmission on its own) to the risk of a major epidemic is greatly diminished as mixing patterns become more assortative, and in such a scenario, a higher proportion of non-maintenance hosts among index cases elevates the probability of extinction. Despite the presence of various other epidemiological factors that undoubtedly influenced the delay between first importations and the subsequent epidemic, these results suggest that the dominance of adults among imported cases represents one of the possible factors explaining the delays in geographic spread observed during the recent pandemic.
Title: Assortativity and the Probability of Epidemic Extinction: A Case Study of Pandemic Influenza A (H1N1-2009)
answer:
True

question:
Paragraph: The genome of coronaviruses contains structural and non-structural genes, including several so-called accessory genes. All group 1b coronaviruses encode a single accessory protein between the spike and envelope genes, except for human coronavirus (HCoV) 229E. The prototype virus has a split gene, encoding the putative ORF4a and ORF4b proteins. To determine whether primary HCoV-229E isolates exhibit this unusual genome organization, we analyzed the ORF4a/b region of five current clinical isolates from The Netherlands and three early isolates collected at the Common Cold Unit (CCU) in Salisbury, UK. Results: All Dutch isolates were identical in the ORF4a/b region at amino acid level. All CCU isolates are only 98% identical to the Dutch isolates at the nucleotide level, but more closely related to the prototype HCoV-229E (>98%). Remarkably, our analyses revealed that the laboratory adapted, prototype HCoV-229E has a 2-nucleotide deletion in the ORF4a/b region, whereas all clinical isolates carry a single ORF, 660 nt in size, encoding a single protein of 219 amino acids, which is a homologue of the ORF3 proteins encoded by HCoV-NL63 and PEDV. Conclusion: Thus, the genome organization of the group 1b coronaviruses HCoV-NL63, PEDV and HCoV-229E is identical. It is possible that extensive culturing of the HCoV-229E laboratory strain resulted in truncation of ORF4. This may indicate that the protein is not essential in cell culture, but the highly conserved amino acid sequence of the ORF4 protein among clinical isolates suggests that the protein plays an important role in vivo.
Title: Virology Journal Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes
answer:
False

question:
Paragraph: Remyelination is a major therapeutic goal in human myelin disorders, serving to restore function to demyelinated axons and providing neuroprotection. The target disorders that might be amenable to the promotion of this repair process are diverse and increasing in number. They range primarily from those of genetic, inflammatory to toxic origin. In order to apply remyelinating strategies to these disorders, it is essential to know whether the myelin damage results from a primary attack on myelin or the oligodendrocyte or both, and whether indeed these lead to myelin breakdown and demyelination. In some disorders, myelin sheath abnormalities are prominent but demyelination does not occur. This review explores the range of human and animal disorders where myelin pathology exists and focusses on defining the myelin changes in each and their cause, to help define whether they are targets for myelin repair therapy. smooth ER in OLs in the myelin mutant taiep rat where it associates with accumulating microtubules. Golgi apparatus: This prominent organelle is involved in vesicular transport and trafficking and the site of post translational modifications of proteins such as PLP and myelin-associated glycoprotein (MAG). The rat mutant, vacuole formation (vf) may be the only myelin mutant with a specific defect in Golgi (see later). Microtubules: Microtubules are essential to the intracellular transport of protein and certain mRNAs (MBP and MAG mRNA) to the cell membrane and developing myelin sheath. The taiep rat has a specific defect in OL microtubules that result in both the initial failure of normal myelin production but also in its subsequent loss (see later). Lysosomes: This organelle is responsible for the intracellular degradation of effete organelles and extracellular materials through the action of hydrolytic enzymes that generate an acidic environment within the lysosome. A specific class of disorders, the lysosomal storage disorders result from a mutation in one of these enzymes that results in a build-up of the respective substrates. Two classic childhood lysosomal storage disorders, Krabbe's disease and metachromatic leukodystrophy result in severe CNS and peripheral nervous system (PNS) demyelination. Peroxisomes: They are involved in the metabolism of lipids in particular the -oxidation of very long chain fatty acids. The primary example of a white matter disorder resulting from peroxisomal dysfunction is adrenoleukodystrophy. Unequivocal proof of myelin pathology and demyelination in the CNS requires definitive morphologic evidence that frequently can be hard to acquire, especially in human tissue. Tissue artifact following immersion fixation, poor perfusion (animals) or a delay in fixation after death is common and can lead to a de-compaction of myelin and misinterpretation of these and other changes. Paradoxically, the best fixation of CNS myelin is achieved where the density and thickness of myelin is less, i.e. in the genetic disorders. It is harder to achieve good fixation of myelin in the normal CNS because of the density and thickness of myelin sheaths perhaps leading to poor penetration of fixatives. The best fixation is achieved by cardiac or aortic perfusion with glutaraldehyde or Karnovsky fixative. In larger animal models, perfusion through the ascending and descending aorta is optimal. Using these methods and fixatives, tissue is processed for embedding in plastic resin that allows both light microscopy (1 micron, toluidine blue stained sections) or electron microscopy (ultrathin sections) to be performed. These sections provide superior resolution and quality to other histologic techniques and are the gold standard in myelin evaluation. Most recently, high pressure freezing of the CNS to avoid aldehyde fixation artifact has provided an alternative method to provide high quality ultrastructural resolution (Mobius et al., 2016) .
Title: Inherited and acquired disorders of myelin: the underling myelin pathology
answer:
False