Instructions: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: IgE is a key mediator in allergic disease. Yet, many details of the composition of the humanIgErepertoireare,instrongcontrasttootherantibodyisotypes,poorlydefined. The low levels of human IgE in circulation and the rarity of IgE-producing B cells are important reasons for this lack of knowledge. In this review we summarize current knowledge of these repertoires both in terms of their complexity and activity, knowledgethatdespitethedifficultiesencounteredwhenstudyingthemoleculardetails of human IgE has been acquired in recent years. We also take a look at likely future developments, for instance through improvements in sequencing technology and methodology that allows isolation of additional allergen-specific human antibodies mimicking IgE, as this certainly will support our understanding of human IgE in the contextofhumandiseaseinyearstocome.
Output:
The human IgE repertoire