Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Riociguat (Adempas(®️)), an oral first-in-class soluble guanylate cyclase (sGC) stimulator, is under global development by Bayer Healthcare Pharmaceuticals Inc. for the treatment of adult patients with inoperable or chronic/persistent chronic thromboembolic pulmonary hypertension (CTEPH) and for the treatment of adult patients with pulmonary arterial hypertension (PAH). The drug directly stimulates sGC in a nitric oxide independent manner, thereby increasing the sensitivity of sGC to nitric oxide, leading to increased cyclic guanosine monophosphate generation (a key signalling molecule involved in regulating vascular tone, proliferation, fibrosis and inflammation). Riociguat is the world's first approved pharmacotherapy for CTEPH, with its first global approval in this indication occurring in Canada. It has subsequently been approved in the USA for the treatment of patients with CTEPH and also received its first global approval in patients with PAH in the USA. It is undergoing regulatory review for these indications in Europe and for use in patients with CTEPH in Japan. This article summarizes the milestones in the development of riociguat, leading to its first global approvals in patients with CTEPH and PAH.
[A]: What is generic name of drug Adempas?

[Q]: NeXTSTEP (also stylized as NeXTstep, NeXTStep, and NEXTSTEP) is a combination of several parts: a Unix operating system based on the Mach kernel, plus source code from BSD Display PostScript and a proprietary windowing engine the Objective-C language and runtime an object-oriented (OO) application layer, including several ''kits'' development tools for the OO layers NeXTSTEP is notable for having been a preeminent implementation of the latter three items.
[A]: What is the programming language for NeXTSTEP?

[Q]: A new canal with a port in Furth, the Rhine-Main-Danube Canal, was completed in 1992, creating a navigable connection from the Rhine delta in Rotterdam to the Danube Delta on the Black Sea.
[A]:
What body of water was Furth next to?