You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a scientific passage and an answer, generate a question for the given answer.

Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Solution: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Why? The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.

New input: Passage: In this equation, two substances combine to make a single substance. This is a composition reaction. Two different substances react to make two new substances. This does not fit the definition of either a composition reaction or a decomposition reaction, so it is neither. In fact, you may recognize this as a double-replacement reaction. A single substance reacts to make multiple substances. This is a decomposition reaction. Answer: composition reaction
Solution:
What type of reaction causes two substances to combine to make a single substance?