Given the task definition and input, reply with output. In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: Which of the following characteristics of the genetic code is NOT CORRECT ?:
Options: <1> The sequence of nitrogenous bases of a given gene has a fixed reading frame and no punctuation marks. <2> It is degenerate, because for many amino acids there is more than one codon that encodes it. <3> The degeneration of the genetic code supposes an adaptive mechanism that reduces the harmful effects of the mutations. <4> It is totally universal, allowing the heterologous expression of human proteins (eg insulin) in prokaryotic organisms such as E. coli. <5> Its reading is always done from the 5'-phosphate end towards the hydroxyl of the messenger RNA (mRNA).
4