Detailed Instructions: Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).
Problem:Abstract: Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heteroduplex induced mutagenesis'. The high frequency of these events suggests that this method may prove useful for introducing mutations into specific mammalian genes.
Which is the apt title for the abstract? option1: Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. option2: Partially thrombosed giant intracranial aneurysms: correlation of MR and pathologic findings.
Solution:
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.