In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormality of coagulation function and proposes that the early intravenous immunoglobulin and low molecular weight heparin anticoagulation therapy are very important. Professor Hongzhou Lu, a leader in China to try various anti-viral drugs, expresses concern on the quality of the ongoing clinical trials as most trials are small in scale and repetitive in nature, and emphasizes the importance of the quick publication of clinical trial results. Regarding the traditional Chinese medicine, Professor Lu suggests to develop a creative evaluation system because of the complicated chemical compositions. Professor Wenhong Zhang is responsible for Shanghai's overall clinical management of the COVID-19 cases. He introduces the team approach to manage COVID-19 patients. For severe or critically ill patients, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very crucial. The medical decisions and interventions are carefully tailored to the unique characteristics of each patient.
Clinical observation and management of COVID-19 patients

Food security in the Middle East is directly affected by a challenging combination of ongoing destructive conflicts, a global economic downturn, widespread poverty, high population growth, corruption, intolerance, and the potentially damaging consequences of climate change. Many Arab countries demonstrate nearly all the features of those countries classified as poor, less developed, or failing to achieve the eight Millennium Goals. Even the economies of the richer oil-exporting countries in the Region have been seriously damaged by the downturn in oil and gas prices as new sources come on stream elsewhere and demand falls as a result of renewable sources of energy becoming available. Climate change predictions for the Region are worrisome even if most of the environmental commitments made by countries at the UN Climate Change Conference in Paris at the end of 2015 are delivered. Large parts of the Region already suffer from periods of extreme temperatures and shortages of fresh water, so harsher conditions of higher temperatures and weather extremes pose special problems for inhabitants and policymakers, with heightened geopolitical risks and uncertainties. Agriculture is especially vulnerable. Modern agricultural technologies with improved cultivars and livestock breeds must displace poor agricultural and pastoral practices. Larger-scale, bettercapitalised production units are required with policy shifts to remove marketdistorting subsidies, tariffs, and other regulatory impedances. Agricultural "roadmaps" are needed to encourage the most appropriate crops and maintain livestock in the most appropriate places. The trading of meat, dairy products and many types of crops to water-poor regions can be regarded as an efficient way to 261 redistribute water. In unsettled times, food security requires protection of foodproducing, food-processing, and food-distribution industries are protected along with research and development facilities, and the maintenance of skilled personnel. There are doubts as to whether agencies of the United Nations, other international agencies, donor countries and charities are able to provide adequate humanitarian aid and humanitarian intervention to enable safeguarding of displaced peoples and ensuring the resumption of normal peaceful conditions essential for food security to be guaranteed. Promises of aid funds must become reality, followed by the establishment of functional supply and transport networks, and rapid transition to self-reliance thereafter. Food security and social stability are inextricably linked. The solution to the food-security problems in the Region ultimately lies in the actions of governments, businesses and individuals. Governments need embedded scientific and technological expertise, strong civil-society institutions, integrity, and a particular focus on high-quality education.
Food Security in an Insecure Future

Interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cell-intrinsic factor that limits influenza virus infections. We previously showed that IFITM3 degradation is increased by its ubiquitination, though the ubiquitin ligase responsible for this modification remained elusive. Here, we demonstrate that the E3 ubiquitin ligase NEDD4 ubiquitinates IFITM3 in cells and in vitro. This IFITM3 ubiquitination is dependent upon the presence of a PPxY motif within IFITM3 and the WW domain-containing region of NEDD4. In NEDD4 knockout mouse embryonic fibroblasts, we observed defective IFITM3 ubiquitination and accumulation of high levels of basal IFITM3 as compared to wild type cells. Heightened IFITM3 levels significantly protected NEDD4 knockout cells from infection by influenza A and B viruses. Similarly, knockdown of NEDD4 in human lung cells resulted in an increase in steady state IFITM3 and a decrease in influenza virus infection, demonstrating a conservation of this NEDD4-dependent IFITM3 regulatory mechanism in mouse and human cells. Consistent with the known association of NEDD4 with lysosomes, we demonstrate for the first time that steady state turnover of IFITM3 occurs through the lysosomal degradation pathway. Overall, this work identifies the enzyme NEDD4 as a new therapeutic target for the prevention of influenza virus infections, and introduces a new paradigm for up-regulating cellular levels of IFITM3 independently of IFN or infection.
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3