Problem: You are given a new situation: Brad and Henry were two old friends in their 70's. Brad had very high levels of cholesterol, while Henry was healthier and had normal levels of cholesterol. and a hint : Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. Please answer this question : Which friend takes a drug that induces the expression of low density lipoprotein (LDL) receptors in the liver?

A: Brad

Problem: Given the question: You are given a new situation: Two brothers had bike repair shops in neighboring towns. Bob's was located in a hilly area, with more precipitation and full of bike trails, so he had more people coming in, while Rob's was in the valley, near the parks. and a hint : In slippery conditions some riders prefer to ride fixed because they believe the transmission provides increased feedback on back tire grip. However, there is also an increased risk of loss of control in such conditions. This is especially so when taking into account the large number of riders who ride brakeless. These riders must brake entirely through the drivetrain. Ideally this is done by resisting the forward motion of the pedals, shedding speed while the bike is still moving. Alternatively, though far less efficiently, one can brake by stopping the motion of the pedals in mid-rotation, causing the rear wheel to lock in place, allowing the bicycle to skid and slow down from kinetic friction (see below).[22] Descending any significant gradient is more difficult as the rider must spin the cranks at high speed (sometimes at 170 rpm or more), or use the brakes to slow down. Some consider that the enforced fast spin when descending increases suppleness or flexibility, which is said to improve pedalling performance on any type of bicycle; however the performance boost is negligible compared to the benefits of riding a free wheel.[23] Please answer this question : Which town had more cyclists riding downhill at high speeds?
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The answer is:
Bob's

input question: You are given a new situation: Two friends named Jill and Jane met after many years and had a chat over a cup of tea. Jane was 70 years-old, while Jill was 55. They shared many stories. and a hint : Old age begins in the mid-60s and lasts until the end of life. Most people over 65 have retired from work, freeing up their time for hobbies, grandchildren, and other interests. Stamina, strength, reflex time, and the senses all decline during old age, and the number of brain cells decreases as well. The immune system becomes less efficient, increasing the risk of serious illnesses such as cancer and pneumonia. Diseases such as Alzheimer's disease that cause loss of mental function also become more common. Please answer this question : Which friend had a smaller chance of developing Alzheimer's disease????
output answer: Jill

You are given a new situation: Bob's parents were in their early 60's. He sent them to the doctor's for a routine check up. Dan, his dad, had very high cholesterol, while Mary, his mom , had normal levels in her blood. and a hint : Cholesterol has been implicated in heart disease for decades. Atherosclerosis is a disorder of the arteries in which cholesterol and other materials are deposited on the interior of the arterial wall. These deposits lead to the formation of plaques that can restrict or even block the flow of blood through these blood vessels (see Figure below ). A decrease in the flow of blood can lead to high blood pressure and a lowered oxygen supply to the heart muscle. A complete blockage of blood flow to parts of the heart (a heart attack) can cause significant damage due to oxygen deprivation, in some cases leading to death. Please answer this question : Which parent had fewer plaques that could potentially block blood flow?
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Answer: Mary

Q: You are given a new situation: Pete lived in Alaska, but visited his friend Julia from Hawaii very often. They had many mutual interests, including geology and earthquakes. and a hint : The Hawaiian Islands ( Figure above ) are in the central Pacific Ocean. The islands are volcanoes that increase in age from southeast to northwest. The youngest island is the Big Island of Hawaii at the southeast end of the chain. The volcanoes get older through Maui, Kahoolawe, Lanai, Molokai, Oahu, Kauai, and Niihau Islands through the northwest. The Kilauea volcano on Hawaii has been erupting almost continuously since 1983. There are also eruptions at an underwater volcano called Loih Please answer this question : Which person lived farther from Kauai island?
A: Pete

[Q]: You are given a new situation: There are two planets, Glarnak and Bornak, that share the same atmospheric composition. The planets have nearly identical ecosystems and topography. The main difference between the two planets is the level of global warming on each planet. Glarnak is experiencing a strong impact from global warming. Bornak, though, is experiencing practically no effects of global warming. and a hint : Pollutants also affect the atmosphere through their contribution to global warming. Global warming is an increase in the Earth's temperature. It is thought to be caused mostly by the increase of greenhouse gases like carbon dioxide. Greenhouse gases can be released by factories that burn fossil fuels. Over the past 20 years, burning fossil fuels has produced about three-quarters of the carbon dioxide from human activity. The rest of the carbon dioxide in the atmosphere is there because of deforestation, or cutting down trees ( Figure below ). Trees absorb carbon dioxide during cellular respiration, so when trees are cut down, they cannot remove carbon dioxide from the air. Please answer this question : Is the average temperature of Bornak higher or lower than Glarnak?
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[A]:
lower