In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: How is the recovery of depression operationalized? (eg, Thase, 2003, APA, 2000):
Options: <1> Reduction of more than 50% of symptoms from the baseline. <2> Reduction of symptoms by more than 75% from the baseline. <3> A score greater than 70 on the Global Activity Assessment Scale (EEAG). <4> Cessation of significant symptoms maintained for at least 6 months and a return to normal functioning. <5> Cessation of significant symptoms for at least the last two months.
4