In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Example Input: Background. Before kidney transplantation, donors and recipients are routinely screened for viral pathogens using specific tests. Little is known about unrecognized viruses of the urinary tract that potentially result in transmission. Using an open metagenomic approach, we aimed to comprehensively assess virus transmission in living-donor kidney transplantation. Methods. Living kidney donors and their corresponding recipients were enrolled at the time of transplantation. Follow-up study visits for recipients were scheduled 4-6 weeks and 1 year thereafter. At each visit, plasma and urine samples were collected and transplant recipients were evaluated for signs of infection or other transplant-related complications. For metagenomic analysis, samples were enriched for viruses, amplified by anchored random polymerase chain reaction (PCR), and sequenced using high-throughput metagenomic sequencing. Viruses detected by sequencing were confirmed using real-time PCR. Results. We analyzed a total of 30 living kidney donor and recipient pairs, with a follow-up of at least 1 year. In addition to viruses commonly detected during routine post-transplant virus monitoring, metagenomic sequencing detected JC polyomavirus (JCPyV) in the urine of 7 donors and their corresponding recipients. Phylogenetic analysis confirmed infection with the donor strain in 6 cases, suggesting transmission from the transplant donor to the recipient, despite recipient seropositivity for JCPyV at the time of transplantation. Conclusions. Metagenomic sequencing identified frequent transmission of JCPyV from kidney transplant donors to recipients. Considering the high incidence rate, future studies within larger cohorts are needed to define the relevance of JCPyV infection and the donor's virome for transplant outcomes.
Example Output: Clinical Infectious Diseases Metagenomic Virome Sequencing in Living Donor and Recipient Kidney Transplant Pairs Revealed JC Polyomavirus Transmission

Example Input: Objectives. To critically appraise the efficacy and safety of Kangfuxinye enema combined with mesalamine for the ulcerative colitis (UC) patients and in addition to grade the quality of evidence by using the GRADE (grading of recommendations, assessment, development, and evaluation) approach. Methods. A literature search was performed in the Cochrane Library, MEDLINE, EMBASE, CBM, CNKI, VIP, and WanFang Databases. The search restrictions were patients with UC and RCTs. Studies including other treatments except Kangfuxinye with mesalamine were excluded. Results. Nineteen studies met the inclusion criteria. We found significant benefits of Kangfuxinye combined with mesalamine against mesalamine alone in improving response rate as well as reducing the recurrence rate and inflammation rate; meanwhile, the increase of the adverse events rate was not observed. Furthermore, the symptoms remission rate and the cure time were insignificant statistically. Additionally, GRADE results indicated that the quality of evidence regarding the above 6 outcomes was rated from very low to moderate quality. Conclusions. Although Kangfuxinye enema seems effective and safe for treating UC patients in this systematic review, Kangfuxinye enema combined with mesalamine was weakly recommended due to very low to moderate quality of available evidence by the GRADE approach.
Example Output: Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach

Example Input: Endoribonucleases participate in almost every step of eukaryotic RNA metabolism, acting either as degradative or biosynthetic enzymes. We previously identified the founding member of the Eukaryotic EndoU ribonuclease family, whose components display unique biochemical features and are flexibly involved in important biological processes, such as ribosome biogenesis, tumorigenesis and viral replication. Here we report the discovery of the CG3303 gene product, which we named DendoU, as a novel family member in Drosophila. Functional characterisation revealed that DendoU is essential for Drosophila viability and nervous system activity. Pan-neuronal silencing of dendoU resulted in fly immature phenotypes, highly reduced lifespan and dramatic motor performance defects. Neuronsubtype selective silencing showed that DendoU is particularly important in cholinergic circuits. At the molecular level, we unveiled that DendoU is a positive regulator of the neurodegenerationassociated protein dTDP-43, whose downregulation recapitulates the ensemble of dendoU-dependent phenotypes. This interdisciplinary work, which comprehends in silico, in vitro and in vivo studies, unveils a relevant role for DendoU in Drosophila nervous system physio-pathology and highlights that DendoUmediated neurotoxicity is, at least in part, contributed by dTDP-43 loss-of-function. We previously identified and characterised the amphibian XendoU protein 1-3 . XendoU is an endoribonuclease involved in the biogenesis of small nucleolar RNAs, which participate in ribosome function 4,5 . Three-dimensional structure determination revealed that XendoU had a novel fold 3 , which led it to be defined the founding member of the Eukaryotic EndoU ribonuclease family by the Structure Classification of Proteins Database (SCOP) 6 . We later characterised another member of the same family, closely related to XendoU, namely human Placental Protein 11 (PP11) 7 , which is highly tissue-specific and represents a tumour-marker in several cancers. Proteins distantly related to XendoU family members are encoded by viruses. They represent genetic markers of nidoviruses 8 , which are responsible for human respiratory diseases, and the Nsp15 prototype is essential in the viral replication cycle 9,10 . Eukaryotic and viral endoribonucleases share a unique combination of biochemical features: Mn 2+ -dependent enzymatic activity, uridylates specificity, and release of products with 2 , 3 -cyclic phosphate termini 1,7 . In this study we investigated the role of XendoU homologs in Drosophila melanogaster. Sequence comparison detected the two protein products encoded by CG2145 and CG3303 genes as XendoU homologs. Deep biochemical analyses revealed that CG3303 product alone shares the aforementioned biochemical features. We named this protein, which is annotated by the major databases as serine protease, DendoU (Drosophila endoribonuclease U-specific). By exploiting the powerful reverse-genetics tools of the fruit fly model system, we investigated DendoU in vivo activity. The protein was found to be essential for Drosophila viability and crucial for neuronal activity. Depletion in the nervous system resulted in severe abnormalities such as immature phenotypes, highly reduced lifespan and impaired locomotion behaviour. These phenotypes overlap with those caused by loss-and gain-of-function of the neurodegeneration-associated protein dTDP-43, which we revealed to be regulated by DendoU.
Example Output:
Drosophila CG3303 is an essential endoribonuclease linked to TDP-43- mediated neurodegeneration OPEN