Given the task definition and input, reply with output. In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: The hypertension developed in hyperaldosteronism is produced by:
Options: <1> Increase in blood calcium. <2> Desensitization of the vascular wall to the vasoconstrictors. <3> Greater release of adrenaline and noradrenaline. <4> Increase in the reabsorption of Na + and H2O. <5> Decrease in blood volume.
4