Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Coming off their divisional road win over the Dolphins, the Jets flew to Ralph Wilson Stadium for a Week 4 AFC East duel with the throwback-clad Buffalo Bills. New York scored in the first quarter as running back LaDainian Tomlinson got a 1-yard touchdown run. The Jets added onto their lead in the second quarter with a 19-yard field goal from kicker Nick Folk, followed by quarterback Mark Sanchez completing a 41-yard touchdown pass to wide receiver Braylon Edwards. The Bills closed out the half with quarterback Ryan Fitzpatrick finding tight end David Martin on a 4-yard touchdown pass. New York pulled away in the third quarter as tight end Dustin Keller caught a 3-yard touchdown pass from wide receiver/quarterback Brad Smith, followed by his 2-yard touchdown reception thrown by Sanchez. Afterwards, Tomlinson's 26-yard touchdown run effectively secured the victory. Buffalo closed out the game in the fourth quarter as Fitzpatrick threw a touchdown pass to wide receiver Steve Johnson.
Which player scored multiple touchdowns?

The SP790 study (ClinicalTrials.gov, NCT00136045) showed benefits of rotigotine over placebo in improving symptom severity of restless legs syndrome (RLS), also known as Willis-Ekbom disease, on the International Restless Legs Syndrome Study Group rating scale (IRLS), Clinical Global Impression item 1 (CGI-1), RLS 6-item questionnaire (RLS-6), and the RLS-quality of life questionnaire (RLS-QoL) in patients with moderate to severe idiopathic RLS. To provide clinical context for the IRLS and to guide the choice of assessment scales for RLS studies, our post hoc analysis of SP790 data evaluated associations between the IRLS and the CGI-1, IRLS and RLS-6, and the IRLS and RLS-QoL. Scale associations were analyzed at baseline and at the end of maintenance (EoM) using data from the safety set (rotigotine and placebo groups combined [n=458]). Changes from baseline to EoM in IRLS score vs comparator scale scores also were analyzed. There was a trend towards increasing IRLS severity category with increasing CGI-1, RLS-6, and RLS-QoL score. Pearson product moment correlation coefficients showed correlations between IRLS and comparator scale scores at baseline and EoM as well as correlations for change from baseline to EoM. Correlations between the IRLS and comparator scales were substantial. These data indicate that the IRLS is clinically meaningful. The IRLS and CGI-1 are generally sufficient to evaluate the overall severity and impact of RLS symptoms in clinical trials.
Willis-Ekbom disease is also known as?

Many studies have reported that the generation of reactive oxygen species (ROS) increases during the differentiation of muscle-derived C2C12 cells. Peroxiredoxin-2 (Prx-2) is an abundant mammalian enzyme that protects against oxidative stress. However, the role of Prx-2 in muscle differentiation has not been investigated. In this study, we demonstrated that Prx-2 expression increases during muscle differentiation and regeneration in response to exogenous H(2)O(2). This increase occurs only in myoblast cell lines because no increase in Prx-2 expression was observed in the NIH3T3, MEF, Chang, or HEK293 cell lines. The antioxidants, N-acetyl L-cysteine (NAC) and 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), both suppressed myogenesis and Prx-2 expression. Moreover, Prx-2 was upregulated at the transcriptional level by NF-B during the differentiation of muscle-derived C2C12 cells. We also found that inhibition of phosphatidylinositol 3-kinase (PI3K) blocks NF-B activation and suppresses Prx-2 expression. Interestingly, Prx-2 knockdown increased the expression levels of other antioxidant enzymes, including all of the other Prx family member, thioredoxin-1 (Trx-1) and catalase, but also enhanced the accumulation of endogenous ROS during muscle differentiation. In this study, we demonstrated for the first time that Prx-2 is unregulated during the muscle differentiation and regeneration. Prx-2 is upregulated via the PI3K/NF-B pathway and attenuates oxidative stress during muscle differentiation and regeneration.
What type of enzyme is peroxiredoxin 2 (PRDX2)?