Detailed Instructions: In this task, you are given a abstract of article and corresponding title of an article. Your task is to generate label "yes" if title is right for article, otherwise generate "no".
Problem:Abstract: Tau aggregation and amyloid protein (A) deposition are the main causes of Alzheimer's disease (AD). Peroxisome proliferator-activated receptor (PPAR) activation modulates A production. To test whether the PPAR agonist pioglitazone (PIO) is also effective in preventing tau aggregation in AD, we used a cellular model in which wild-type tau protein (4R0N) is overexpressed (M1C cells) (Hamano et al., 2012) as well as primary neuronal cultures. PIO reduced both phosphorylated and total tau levels, and inactivated glycogen synthase kinase 3, a major tau kinase, associated with activation of Akt. In addition, PIO decreased cleaved caspase3 and C-terminal truncated tau species by caspase, which is expected to decrease tau aggregation. A fractionation study showed that PIO reduced high molecular-weight (120 kDa), oligomeric tau species in Tris Insoluble, sarkosyl-soluble fractions. Tau decrease was reversed by adding GW9662, a PPAR antagonist. Together, our current results support the idea that PPAR agonists may be useful therapeutic agents for AD.. Title: Pioglitazone prevents tau oligomerization.
Solution:
yes