With Upper Burma securely under his control, Nyaungyan's successor Anaukpetlun marched south. His 14,000-strong land and naval forces sacked Prome on 13 July 1608 after a bloody siege of eight months. His 12,000-strong forces then attacked Toungoo, then ruled by his cousin, Natshinnaung, in August 1610. After a siege of 23 days, Natshinnaung agreed to become a vassal on 4 September 1610. But Natshinnaung was deeply unhappy with his reduced status, and secretly invited de Brito of Syriam to attack Toungoo. In July 1612, Syriam and Martaban forces ransacked the city for ten days, and left, taking Natshinnaung to Syriam. In response, Anaukpetlun's army of 13,000 left Ava for Syriam on 26 December 1612. A flotilla of 80 war boats and 30 cargo boats was also sent down the Irrawaddy to blockade the port. The Burmese forces overcame Portuguese outer defences, and finally blockaded the port on 24 February 1613. But Portuguese gunners and musketeers kept the Burmese at bay for 34 days while waiting for reinforcements from Goa to arrive. On 29 March 1613, however, the Burmese successfully brought down a section of the walls, from their tunnels below. The city was sacked. On 7 April 1613, de Brito his son and Natshinnaung were all executed by impalement. A month later, on 14 May 1613, Binnya Dala of Martaban, submitted. The ruler was nominally tributary to Siam but had ruled the region like a sovereign since the death of Naresuan in 1605. Alarmed, the Siamese sent an army to Ye, south of Martaban, to prevent the Burmese from marching down the coast. But the Siamese did not try to retake Martaban.

Who died first, Naresuan or Natshinnaung?
A: Naresuan

The Yuan emperor Ayurbarwarda maintained friendly relations with Oljaitu, ruler of the Ilkhanate. As for the relations with the Chagatai Khanate, the Yuan forces had, in fact, already for a long time been entrenched in the east. This was originally meant to keep Chapar in submission, but since the latter's defeat in 1310, the garrisons were perceived as a threat to the Chaghadaid state. In order to solve the shortages of pasture grounds, Esen Buqa I, ruler of the Chagatai Khanate sent envoys in an attempt to negotiate with the border garrison commander Tughaji Jinsank in order to convince them to adjust their position in 1312. The negotiations, however, did not go well, and strained relations between the two. Esen Buqa sent tributes to Ayurbarwada in 1312 and 1313, but the Yuan court's attempts to restrict trade between the two states kept tensions high. Ayurbarwada's emissary, Abishqa, to the Ilkhanate while travelling through Central Asia, revealed to a Chaghadayid commander that an alliance between the Yuan and the Ilkhanate had been created, and the allies forces were mobilizing to attack the khanate. Esen Buqa ordered Abishqa to be executed and decided to attack the Yuan because of these events, thus breaking the peace that his father Duwa had brokered with China in 1304. At the same time, Muslim Ozbeg Khan mounted the throne of the Golden Horde in 1312. He proscribed Buddhism and Shamanism among the Mongols in Russia, reversing the spread of the Yuan culture. Yuan envoys seems to have backed Toqta's son, a rival candidate, against Ozbeg. Esen Buqa attempted to gain an alliance of Ozbeg Khan against the Yuan and the Ilkhanate, but without success.

How was Duwa related to Esen Buqa?
A: his father

The Cochrane Library had 145 CAM-related Cochrane systematic reviews and 340 non-Cochrane systematic reviews. An analysis of the conclusions of only the 145 Cochrane reviews was done by two readers. In 83% of the cases, the readers agreed. In the 17% in which they disagreed, a third reader agreed with one of the initial readers to set a rating. These studies found that, for CAM, 38.4% concluded positive effect or possibly positive (12.4%), 4.8% concluded no effect, 0.7% concluded harmful effect, and 56.6% concluded insufficient evidence. An assessment of conventional treatments found that 41.3% concluded positive or possibly positive effect, 20% concluded no effect, 8.1% concluded net harmful effects, and 21.3% concluded insufficient evidence. However, the CAM review used the more developed 2004 Cochrane database, while the conventional review used the initial 1998 Cochrane database.

How many percent of readers did not conclude no effect?
A:
95.2