Information: - Fifty Classic Climbs Of North America is a climbing guidebook and history written by Steve Roper and Allen Steck. It is considered a classic piece of climbing literature, known to many climbers as simply "The Book", and has served as an inspiration for more recent climbing books, such as Mark Kroese's "Fifty Favorite Climbs". Though much of the book's contents are now out of date, it is still recognized as a definitive text which goes beyond the traditional guidebook. - Steve Roper is a noted climber and historian of the Sierra Nevada in the United States. He along with Allen Steck are the founding editors of the Sierra Club journal "Ascent". - Allen Steck (born 1926) is an American mountaineer and rock climber. He is a native of Oakland, California. - Climbing is the activity of using one's hands, feet, or any other part of the body to ascend a steep object. It is done recreationally, competitively, in trades that rely on it, and in emergency rescue and military operations. It is done indoors and out, on natural and manmade structures. - Scrambling (also known as alpine scrambling) is "a walk up steep terrain involving the use of one's hands". It is an ambiguous term that lies somewhere between hiking, hillwalking, mountaineering, and easy rock climbing. Canyoning often involves scrambling. - Rock climbing is an activity in which participants climb up, down or across natural rock formations or artificial rock walls. The goal is to reach the summit of a formation or the endpoint of a usually pre-defined route without falling. Due to the length and extended endurance required and because accidents are more likely to happen on descent than ascent, Rock Climbers do not usually climb back down the route. It is very rare for a climber to downclimb, especially on the larger multiple pitches (class III- IV and /or multi-day grades IV-VI climbs). Professional Rock climbing competitions have the objectives of either completing the route in the quickest possible time or attaining the farthest point on an increasingly difficult route. Scrambling, another activity involving the scaling of hills and similar formations, is similar to rock climbing. However, rock climbing is generally differentiated by its sustained use of hands to support the climber's weight as well as to provide balance. - The Southeast Face of Clyde Minaret is a technical rock climbing route on Clyde Minaret near Mammoth Lakes , CA and is featured in Fifty Classic Climbs of North America . After reading the paragraphs above, we are interested in knowing the entity with which 'southeast face ' exhibits the relationship of 'located in the administrative territorial entity'. Find the answer from the choices below. Choices: - alpine - california - date - goes - nevada - north america - of - rock - time
california

Information: - Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR). - Cycloguanil is a dihydrofolate reductase inhibitor , and is a metabolite of the antimalarial drug proguanil ; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil . However , more recent work has indicated that , while proguanil is synergistic with the drug atovaquone ( as in the combination Malarone ) , cycloguanil is in fact antagonistic to the effects of atovaquone , suggesting that , unlike cycloguanil , proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition . Although cycloguanil is not currently in general use as an antimalarial , the continuing development of resistance to current antimalarial drugs has led to renewed interest in studying the use of cycloguanil in combination with other drugs . - Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the "DHFR" gene. It is found in the q11q22 region of chromosome 5. Bacterial species possess distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. - A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. - Atovaquone (alternative spelling: atavaquone) is a chemical compound that belongs to the class of naphthoquinones. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. It is manufactured in the US in the liquid form, or oral suspension, under the brand name Mepron. After reading the paragraphs above, we are interested in knowing the entity with which 'cycloguanil' exhibits the relationship of 'instance of'. Find the answer from the choices below. Choices: - activity - brand - chemical compound - class - dna - electron - enzyme - function - gene - humans - liquid - molecule - species - vitamin - work
chemical compound