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Sublethal doses of photon irradiation (IR) are suspected to increase tumor cell migration and support locoregional recurrence of disease, which has already been shown in other cell lines. This manuscript describes the effect of photon and carbon-ion IR on WHO class I meningioma cell migration and provides an approach to the underlying cellular mechanisms.', "Meningioma cells were gained operatively at the university hospital in Homburg/Saar, Germany. For migration, membranes (8-m pore sizes) were coated with collagen I, with collagen IV, and with fibronectin. Cells were analyzed in migration experiments with or without serum stimulation, with or without photon and carbon IR 24h prior to experiments, and with or without integrin antibodies. Fluorescence-activated cell sorting (FACS) analyses of the integrins 1, 3, and 5 were performed without IR and 6, 12 and 24h after IR. Enzyme-linked immunosorbent assay (ELISA) analyses of matrix metalloproteinases (MMP)-2 and MMP-9 were realized with and without IR after cells were cultured on collagen I, collagen IV, or fibronectin for 24h. Cells and supernatants for FACS and ELISA were stored at -18C. The significance level was set at 5% using both Student's t test and two-way ANOVA.", 'Migration of meningioma cells was serum-inducible (p<0.001). It could be increased by photon IR (p<0.02). The integrins 1 and 5 showed a 21 and 11% higher expression after serum stimulation (not significant), respectively, and 1 expression was raised by 14% (p=0.0057) after photon IR. Antibody blockage of the integrins 1 and 5 inhibited serum- and photon-induced migration. Expression of MMP-2 and MMP-9 remained unchanged after both IR and fetal bovine serum (FBS). Carbon-ion IR left both integrin expression and meningioma cell migration unaffected.
Is integrin-based meningioma cell migration promoted by photon but not by carbon-ion irradiation?