instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Is haploinsufficiency the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease?
Answer: The detailed characterization of this animal model provides the first in vivo evidence that Elovl4 haploinsufficiency is not the underlying key disease mechanism in STGD3. The results are consistent with a dominant negative mechanism for the deletion mutation. The Elovl4 knockout mouse is one of three complementary animal models that will help elucidate the disease mechanism.
answer:
no

question:
Question: Do apolipoprotein E genotypes influence the age of onset in Huntington 's disease?
Answer: The ApoE genotype does not affect the course of HD significantly.
answer:
no

question:
Question: Does p53 Activity dominate That of p73 upon Mdm4 Loss in Development and Tumorigenesis?
Answer: Genetic characterization of the Mdm4 and p73 interaction during development and tumorigenesis suggests new insight into the role of p53 family members, which may influence treatment options for patients.
answer:
yes