TASK DEFINITION: In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
PROBLEM: Paragraph: Topography-induced twisted wind flows are frequently observed in Hong Kong due to the abundance existence of mountains. Observed twisted wind profiles are with larger wind twist angles and are confined to the lower 500 m of the atmosphere, thus may impose significant effects on both structures and near-ground wind conditions. In order to investigate the influences of twisted wind flows on the pedestrian-level wind environment, two twisted wind profiles were simulated in a boundary layer wind tunnel by using 1.5 m tall wooden vanes. The maximum guide angles of vanes were 15and 30at the ground level to represent two nominal yaw angles of 'high' and 'extreme' twisted wind flows. Simulated twisted wind profiles followed the power-law profile and have acceptable longitudinal and lateral turbulence power spectra similar to conventional wind flows. The yaw angle profiles were exponentially decayed with the height but had smaller maximum yaw angles than of the guide vanes. The evaluation of wind conditions near an isolated building and a row of buildings in twisted wind flows has displayed substantially modified flow features such as asymmetric wind speed distributions about the building centre line and reduced wind speeds in the passages between buildings.
Title: Simulation of twisted wind flows in a boundary layer wind tunnel for pedestrian-level wind tunnel tests

SOLUTION: True

PROBLEM: Paragraph: Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies. While natural killer (NK) cells can directly contribute to the control of viral replication, whether, and how, they may help orchestrate global antiviral defense is largely unknown. To address this question, we took advantage of the welldefined molecular interactions involved in the recognition of mouse cytomegalovirus (MCMV) by NK cells. By using congenic or mutant mice and wild-type versus genetically engineered viruses, we examined the consequences on antiviral CD8 T cell responses of specific defects in the ability of the NK cells to control MCMV. This system allowed us to demonstrate, to our knowledge for the first time, that NK cells accelerate CD8 T cell responses against a viral infection in vivo. Moreover, we identify the underlying mechanism as the ability of NK cells to limit IFN-a/b production to levels not immunosuppressive to the host. This is achieved through the early control of cytomegalovirus, which dramatically reduces the activation of plasmacytoid dendritic cells (pDCs) for cytokine production, preserves the conventional dendritic cell (cDC) compartment, and accelerates antiviral CD8 T cell responses. Conversely, exogenous IFN-a administration in resistant animals ablates cDCs and delays CD8 T cell activation in the face of NK cell control of viral replication. Collectively, our data demonstrate that the ability of NK cells to respond very early to cytomegalovirus infection critically contributes to balance the intensity of other innate immune responses, which dampens early immunopathology and promotes optimal initiation of antiviral CD8 T cell responses. Thus, the extent to which NK cell responses benefit the host goes beyond their direct antiviral effects and extends to the prevention of innate cytokine shock and to the promotion of adaptive immunity.
Title: Natural Killer Cells Promote Early CD8 T Cell Responses against Cytomegalovirus

SOLUTION: False

PROBLEM: Paragraph: We describe the isolation, biological and genetic characterization of a host-range variant of bovine coronavirus (BCoV) detected in water buffalo (Bubalus bubalis). By conventional and real-time RT-PCR assays, the virus was demonstrated in the intestinal contents of two 20-day-old buffalo calves dead of a severe form of enteritis and in the feces of additional 17 buffalo calves with diarrhea. Virus isolation, hemagglutination and receptor-destroying enzyme activity showed that the buffalo coronavirus (BuCoV) is closely related to BCoV but possesses some different biological properties. Sequence and phylogenetic analyses of the 3 end (9.6 kb) of the BuCoV RNA revealed a genomic organization typical of group 2 coronaviruses. Moreover, the genetic distance between BuCoV and BCoV was proven to be the same or even higher than the distance between other ruminant coronaviruses and BCoV. In conclusion, our data support the existence of a host-range variant of BCoV associated with enteritis in buffaloes.
Title: Biological and genetic analysis of a bovine-like coronavirus isolated from water buffalo (Bubalus bubalis) calves

SOLUTION:
True