Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. Uncle Tom and uncle Sam both have high cholesterol. Uncle Tom is on statin drugs and uncle Sam is not. Which uncle takes an inhibitor of HMG-CoA reductase?
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Answer: Tom

Q: Air pollution can also indirectly cause other health issues and even deaths. Air pollutants can cause an increase in cancer including lung cancer, eye problems, and other conditions. For example, using certain chemicals on farms, such as the insecticide DDT (dichlorodiphenyltrichloroethane) and toxic PCBs (polychlorinated biphenyl), can cause cancer. Indoors, pollutants such as radon or asbestos can also increase your cancer risk. Lastly, air pollution can lead to heart disease, including heart attack and stroke. The health inspectors reviewed data from two villages, Key and Auburn. Key village presented higher levels of both indoor and outdoor pollution. Which village had a lower level of air pollutants?
A: Auburn

Question: Besides anthropogenic productivity of the land, the biodiversity of degraded land also declines, as previously mentioned.[12] With less biodiversity, this ecosystem is less adaptable to when disasters strike it[11][8] It has a smaller available food supply, in terms of plants, for animals, who then may die out or more likely may relocate. Proof of this decline is that presently 15-20% of Tibetan Plateau species are now considered endangered; and now because of this animal and plant absence, the soil quality of these degraded lands is very poor.[1] It does not hold the necessary nutrients, such as water, nitrogen, and carbon, essential to either supporting life or inviting life back to that land.[6] As a result of such carbon and nitrogen loss in the Tibetan Plateau, $8,033/ha and $13,315/ha were respectively lost in economic terms. Soils are further weakened by dust storms whose frequency increases because of degradation.[11][4] Erosion of soil becomes a bigger problem, since no longer are there as many plants to anchor in the soil. In the northern Chinese province alone, 400 million are affected every year with an associated 54 billion yuan of annual economic loss due to grassland degradation. Both Nicaragua and Costa Rica had large tract of pristine forests. They had one of the largest concentration of tropical species. In the 1980s Nicaragua started clearing up some of these forests. Instead, they have now vast tract of sugarcane production in that land. One can still visit Costa Rica where they kept those pristine forests intact. If a disaster strikes, would Nicaragua's ecosystem adapt or fail?
Answer: fail

[Q]: Wind causes the generation of sound. The movement of air causes movements of parts of natural objects, such as leaves or grass. These objects will produce sound if they touch each other. Even a soft wind will cause a low level of environmental noise. If the wind is blowing harder, it may produce howling sounds of varying frequencies. This may be caused by the wind blowing over cavities, or by vortices created in the air downstream of an object. Especially on high buildings, many structural parts may be a cause of annoying noise at certain wind conditions. Examples of these parts are balconies, ventilation openings, roof openings or cables. George lives in a rural area and has a sort of barren forest behind his house. Sometimes, especially when it is storming spooky sounds can be heard that scare George and he has no idea what they are. When it is storming, is George more or less likely to hear howling noises?
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[A]: more

input: Please answer the following: The benefits provided by no-tillage to predators may lead to larger predator populations, which is a good way to control pests (biological control), but also can facilitate predation of the crop itself. In corn crops, for instance, predation by caterpillars can be higher in no-till than in conventional tillage fields.In places with rigorous winter, untilled soil can take longer to warm and dry in spring, which may delay planting to less ideal dates. Another factor to be considered is that organic residue from the prior year's crops lying on the surface of untilled fields can provide a favorable environment to pathogens, helping to increase the risk of transmitting diseases to the future crop. And because no-till farming provides good environment for pathogens, insects and weeds, it can lead farmers to a more intensive use of chemicals for pest control. Other disadvantages of no-till include underground rot, low soil temperatures and high moisture.Based on the balance of these factors, and because each farm has different problems, agroecologists will not attest that only no-till or complete tillage is the right way of farming. Yet, these are not the only possible choices regarding soil preparation, since there are intermediate practices such as strip-till, mulch-till and ridge-till, all of them just as no-till categorized as conservation tillage. Agroecologists, then, will evaluate the need of different practices for the contexts in which each farm is inserted. Barb and Jill practiced small scale farming. Jill farmed the conventional way, while barb used the no-tillage method. Which farmer didn't cause the predation of the crop itself?
++++++++++
output: Jill

During the Cold War, the Arctic became a place where the United States, Canada, and the Soviet Union performed significant research that has been essential to the study of climate change in recent years. A major reason why research in the Arctic is essential for the study of climate change is because the effects of climate change will be felt more quickly and more drastically in higher latitudes of the world as above average temperatures are predicted for Northwest Canada and Alaska. From an anthropological point of view, researchers study the native Inuit peoples of Alaska as they have become extremely accustomed to adapting to ecological and climate variability.[1] Two sister cities, located at different altitude, are affected differently by climate change. Bergen is at 60 degrees N, while Seattle is at 47 degrees N latitude. Which city experienced fewer temperatures above average?
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Answer:
Seattle