Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: The blockage of transcription elongation by RNA polymerase II (pol II) at a DNA damage site on the transcribed strand triggers a transcription-coupled DNA repair (TCR), which rapidly removes DNA damage on the transcribed strand of the expressed gene and allows the resumption of transcription. To analyze the effect of UV-induced DNA damage on transcription elongation, an in vitro transcription elongation system using pol II and oligo(dC)-tailed templates containing a cyclobutane pyrimidine dimer (CPD) or 6-4 photoproduct (6-4PP) at a specific site was employed. The results showed that pol II incorporated nucleotides opposite the CPD and 6-4PP and then stalled. Pol II formed a stable ternary complex consisting of pol II, the DNA damage template, and the nascent transcript. Furthermore, atomic force microscopy imaging revealed that pol II stalled at the damaged region. These findings may provide the basis for analysis of the initiation step of TCR.

A: Which gene strand is targeted by transcription-coupled repair (TCR)?
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Q: MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present the first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II). The primary miRNA transcripts (pri-miRNAs) contain cap structures as well as poly(A) tails, which are the unique properties of class II gene transcripts. The treatment of human cells with alpha-amanitin decreased the level of pri-miRNAs at a concentration that selectively inhibits pol II activity. Furthermore, chromatin immunoprecipitation analyses show that pol II is physically associated with a miRNA promoter. We also describe, for the first time, the detailed structure of a miRNA gene by determining the promoter and the terminator of mir-23a approximately 27a approximately 24-2. These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes.

A: Which polymerase transcribes pri-miRNAs?
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Q: Lake Forest High School Clubs Environmental Club Club members are provided opportunities to realize their goals of environmental service. The majority of projects are student-initiated. Last year's activities included: the LFHS Courtyard Garden upkeep, Bike to School Day with free cocoa and snacks, an "eat local" 100-mile dinner, recycling solutions for LFHS, beach cleanup through the Great Lakes Alliance, and Earth Week celebrations. Meetings: First Friday of the month in Room 5 at 7:00 a.m. Advisor: Ms Mary Beth Nawor, _ Peer Tutoring Students volunteer to help fellow students in improving their academic and organizational skills. Students tutor LFHS and middle school students on an individually scheduled basis. LFHS tutors must have proficiency in the academic area in which they wish to tutor, but middle school tutors only need general academic proficiency. Meetings: All tutoring is done on an individually scheduled basis. Advisor: Ms Kathy O'Hara, _ Young Idea Young Idea is LFHS's art and literary magazine. Students of all ages who love writing and art are encouraged to become part of the staff of this award-winning magazine. Young Idea encourages all students to submit art and literature works to the magazine, whether they are a part of the staff or not. From September to February, Young Idea meets on Thursdays after school in the Public Room to discuss the pieces that have been submitted to the magazine and provide feedback for the authors. Meetings: See above explanation. Advisor: Ms Debbie Zare, _ Scout Buddies Scout Buddies is a friendship club which helps build friendship among individuals with and without disabilities. Club members participate in a variety of social activities both within the school and in the community. Activities include organizing holiday parties in the school, bowling, going to the movies, and eating out in local restaurants. Meetings: Monthly meeting dates vary, but in Room 134. Advisor: Ms Donna Lovitsch, _

A:
Which club provides help for students poor in study?
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