Detailed Instructions: In this task, you are given Wikipedia articles on a range of topics, we ask you to write a question based on the content of the articles that can be answered in a binary manner i.e. True or False.
Problem:Antihistamine -- Second-generation antihistamines cross the blood--brain barrier to a much lower degree than the first-generation antihistamines. Their main benefit is they primarily affect peripheral histamine receptors and therefore are less sedating. However, high doses can still induce drowsiness through acting on the central nervous system. Some second-generation antihistamines, notably cetirizine, can interact with CNS psychoactive drugs such as bupropion and benzodiazepines.
Solution:
do second generation antihistamines cross the blood brain barrier