Problem: Most mutations within genes are neutral, having no effect on the organism's phenotype (silent mutations). Some mutations do not change the amino acid sequence because multiple codons encode the same amino acid (synonymous mutations). Other mutations can be neutral if they lead to amino acid sequence changes, but the protein still functions similarly with the new amino acid (e.g. conservative mutations). Many mutations, however, are deleterious or even lethal, and are removed from populations by natural selection. Genetic disorders are the result of deleterious mutations and can be due to spontaneous mutation in the affected individual, or can be inherited. Finally, a small fraction of mutations are beneficial, improving the organism's fitness and are extremely important for evolution, since their directional selection leads to adaptive evolution.:7.6
What are mutations that lead to amino acid sequence changes but leave the protein functioning similarly called?
The answer is the following: conservative mutations

Since the system's launch, production costs have been reduced significantly as a result of phasing out the Emotion Engine chip and falling hardware costs. The cost of manufacturing Cell microprocessors has fallen dramatically as a result of moving to the 65 nm production process, and Blu-ray Disc diodes have become cheaper to manufacture. As of January 2008, each unit cost around $400 to manufacture; by August 2009, Sony had reduced costs by a total of 70%, meaning it only costs Sony around $240 per unit.
The August 2009 cost is a result of what percentage decrease in production cost?
70%

Input: Political philosophy
Political and economic relations were drastically influenced by these theories as the concept of the guild was subordinated to the theory of free trade, and Roman Catholic dominance of theology was increasingly challenged by Protestant churches subordinate to each nation-state, which also (in a fashion the Roman Catholic Church often decried angrily) preached in the vulgar or native language of each region. However, the enlightenment was an outright attack on religion, particularly Christianity. The most outspoken critic of the church in France was Francois Marie Arouet de Voltaire, a representative figure of the enlightenment. After Voltaire, religion would never be the same again in France.

The concept of the guild was subordinated to the theory of what?
Output: free trade

Input: Article: An MP3 file is made up of MP3 frames, which consist of a header and a data block. This sequence of frames is called an elementary stream. Due to the "byte reservoir", frames are not independent items and cannot usually be extracted on arbitrary frame boundaries. The MP3 Data blocks contain the (compressed) audio information in terms of frequencies and amplitudes. The diagram shows that the MP3 Header consists of a sync word, which is used to identify the beginning of a valid frame. This is followed by a bit indicating that this is the MPEG standard and two bits that indicate that layer 3 is used; hence MPEG-1 Audio Layer 3 or MP3. After this, the values will differ, depending on the MP3 file. ISO/IEC 11172-3 defines the range of values for each section of the header along with the specification of the header. Most MP3 files today contain ID3 metadata, which precedes or follows the MP3 frames, as noted in the diagram.

Now answer this question: What is a sequence of MP3 frames called?

Output: elementary stream

Article: With 39,000 acres (158 km2), the Tallgrass Prairie Preserve in north-central Oklahoma is the largest protected area of tallgrass prairie in the world and is part of an ecosystem that encompasses only 10 percent of its former land area, once covering 14 states. In addition, the Black Kettle National Grassland covers 31,300 acres (127 km2) of prairie in southwestern Oklahoma. The Wichita Mountains Wildlife Refuge is the oldest and largest of nine national wildlife refuges in the state and was founded in 1901, encompassing 59,020 acres (238.8 km2).

Question: How large is the Tallgrass Prairie Preserve?
Ans: 39,000 acres

Input: Kathmandu
Five major climatic regions are found in Nepal. Of these, Kathmandu Valley is in the Warm Temperate Zone (elevation ranging from 1,2002,300 metres (3,9007,500 ft)), where the climate is fairly temperate, atypical for the region. This zone is followed by the Cool Temperate Zone with elevation varying between 2,1003,300 metres (6,90010,800 ft). Under Koppen's climate classification, portions of the city with lower elevations have a humid subtropical climate (Cwa), while portions of the city with higher elevations generally have a subtropical highland climate. In the Kathmandu Valley, which is representative of its valley's climate, the average summer temperature varies from 2830 C (8286 F). The average winter temperature is 10.1 C (50.2 F).

How many significant climate regions exist in Nepal?
Output:
Five