Given a scientific passage and an answer, generate a question for the given answer.
One example: Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Solution is here: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Explanation: The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.

Now, solve this: Passage: Smoking is the major cause of chronic respiratory disease as well as cardiovascular disease and cancer. Exposure to tobacco smoke by smoking or by breathing air that contains tobacco smoke is the leading cause of preventable death in the United States. Regular smokers die about 10 years earlier than nonsmokers do. The Centers for Disease Control and Prevention (CDC) describes tobacco use as "the single most important preventable risk to human health in developed countries and an important cause of [early] death worldwide. " Simply stated: Stopping smoking can prevent many respiratory diseases. Answer: smoking
Solution:
What is the major cause of chronic respiratory disease as well as cardiovascular disease and cancer?