Premise: Originals of Donatello's sculpture are kept in the cathedral's own newly renovated museum, Museo dell'Opera del Duomo (Piazza del Duomo, 9) as well as Michelangelo's unfinished Piet?.

Hypothesis: Donatello's and Michelangelo's original sculptures are housed in the cathedral's museum.
Answer: yes

Premise: (Of course, if it helps keep you in business, by all means carry on.)

Hypothesis: Continue, if it helps keep you in business.
Answer: yes

Premise: and not many people can afford to spend a hundred dollars on the weekend

Hypothesis: Most people cannot afford a weekend where they spend a hundred dollars.
Answer: yes

Premise: In this regard, it serves as a communications conduit between management and the information systems staff who design, build, and implement new applications.

Hypothesis: The information staff don't implement new stuff, but just test-run them.
Answer: no