The average annual rainfall ranges from very low in the northern and southern fringes of the desert to nearly non-existent over the central and the eastern part. The thin northern fringe of the desert receives more winter cloudiness and rainfall due to the arrival of low pressure systems over the Mediterranean Sea along the polar front, although very attenuated by the rain shadow effects of the mountains and the annual average rainfall ranges from 100 mm (3,93 in) to 250 mm (9,84 in). For example, Biskra, Algeria and Ouarzazate, Morocco are found in this zone. The southern fringe of the desert along the border with the Sahel receives summer cloudiness and rainfall due to the arrival of the Intertropical Convergence Zone from the south and the annual average rainfall ranges from 100 mm (3,93 in) to 250 mm (9,84 in). For example, Timbuktu, Mali and Agadez, Niger are found in this zone. The vast central hyper-arid core of the desert is virtually never affected by northerly or southerly atmospheric disturbances and permanently remains under the influence of the strongest anticyclonic weather regime and the annual average rainfall can drop to less than 1 mm (0.04 in). In fact, most of the Sahara receives less than 20 mm (0.79 in). Of the 9,000,000 km2 of desert land in the Sahara, an area of about 2,800,000 km2 (about 31% of the total area) receives an annual average rainfall amount of 10 mm (0.39 in) or less, while some 1,500,000 km2 (about 17% of the total area) receive an average of 5 mm or less. The annual average rainfall is virtually zero over a wide area of some 1,000,000 km2 in the eastern Sahara comprising deserts of Libya, Egypt and Sudan (Tazirbu, Kufra, Dakhla, Kharga, Farafra, Siwa, Asyut, Sohag, Luxor, Aswan, Abu Simbel, Wadi Halfa) where the long-term mean approximates 0.5 mm per year. The rainfall is very unreliable and erratic in the Sahara as it may vary considerably year by year. In full contrast to the negligible annual rainfall amounts, the annual rates of potential evaporation are extraordinarily high, roughly ranging from 2,500 mm/year to more than 6,000 mm/year in the whole desert. Nowhere else on Earth has air been found as dry and evaporative as in the Sahara region. With such an evaporative power, the Sahara can only be desiccated and dried out further more and the moisture deficit is tremendous.
What is the reason the northern fringe receives more cloudiness and rainfall?
low pressure systems

The 19th-century Liberal Prime Minister William Ewart Gladstone considered Burke "a magazine of wisdom on Ireland and America" and in his diary recorded: "Made many extracts from Burkesometimes almost divine". The Radical MP and anti-Corn Law activist Richard Cobden often praised Burke's Thoughts and Details on Scarcity. The Liberal historian Lord Acton considered Burke one of the three greatest Liberals, along with William Gladstone and Thomas Babington Macaulay. Lord Macaulay recorded in his diary: "I have now finished reading again most of Burke's works. Admirable! The greatest man since Milton". The Gladstonian Liberal MP John Morley published two books on Burke (including a biography) and was influenced by Burke, including his views on prejudice. The Cobdenite Radical Francis Hirst thought Burke deserved "a place among English libertarians, even though of all lovers of liberty and of all reformers he was the most conservative, the least abstract, always anxious to preserve and renovate rather than to innovate. In politics he resembled the modern architect who would restore an old house instead of pulling it down to construct a new one on the site". Burke's Reflections on the Revolution in France was controversial at the time of its publication, but after his death, it was to become his best known and most influential work, and a manifesto for Conservative thinking.
What countries did Gladstone think Burke was wise about?
Ireland and America

A number of medications are being studied for multi drug resistant tuberculosis including: bedaquiline and delamanid. Bedaquiline received U.S. Food and Drug Administration (FDA) approval in late 2012. The safety and effectiveness of these new agents are still uncertain, because they are based on the results of a relatively small studies. However, existing data suggest that patients taking bedaquiline in addition to standard TB therapy are five times more likely to die than those without the new drug, which has resulted in medical journal articles raising health policy questions about why the FDA approved the drug and whether financial ties to the company making bedaquiline influenced physicians' support for its use
What drug in the running to treat multi drug resistant TB has already gotten FDA approval?
Bedaquiline