Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: In the present study, we tested the hypothesis that having migraine in middle age is related to late-life parkinsonism and a related disorder, restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED). The AGES-Reykjavik cohort (born 1907-1935) has been followed since 1967. Headaches were classified based on symptoms assessed in middle age. From 2002 to 2006, 5,764 participants were reexamined to assess symptoms of parkinsonism, diagnosis of Parkinson disease (PD), family history of PD, and RLS/WED. Subjects with midlife migraine, particularly migraine with aura (MA), were in later life more likely than others to report parkinsonian symptoms (odds ratio [OR]MA = 3.6 [95% CI 2.7-4.8]) and diagnosed PD (ORMA = 2.5 [95% CI 1.2-5.2]). Women with MA were more likely than others to have a parent (ORMA = 2.26 [95% CI 1.3-4.0]) or sibling (ORMA = 1.78 [95% CI 1.1-2.9]) with PD. Late-life RLS/WED was increased for headache generally. Associations were independent of cardiovascular disease and MRI-evident presumed ischemic lesions. These findings suggest there may be a common vulnerability to, or consequences of, migraine and multiple indicators of parkinsonism. Additional genetic and longitudinal observational studies are needed to identify candidate pathways that may account for the comorbid constellation of symptoms.
Question: Willis-Ekbom disease is also known as?

Answer: restless legs syndrome

Question: Context: My first visit to Angkor Wat was in 1980. The country had been at war for many years and _ and falling to pieces. Plants were growing out of the roofs, and trees were growing in the courtyards. Today, the temple is the scene of a busy repair program. A team of 15 Indian experts are organizing a workforce of 400 Cambodians, most of them women, who are cleaning, repairing and rebuilding parts of this temple. As I walked through the courtyards, I noticed the Cambodian women devote hours to cleaning carefully a tiny area of stone. Boards are laid down to protect the precious painted stones while the repair work is going on. There are very few machines and little heavy equipment. Workers carry building materials in buckets at the end of long poles. Piles of stones lie in a corner of the courtyard, waiting to be replaced. The work of cleaning the stones is watched over by three Indian chemists. It is a very slow task. First they clean the stones with brushes using buckets of a weak chemical. Then gaps between the stones are filled in. Finally another material is painted onto the stones which will protect them from water forever. Work starts every day at 7 a. m. and goes on until late afternoon six days a week, with a break at midday. Evening is the best time to visit the temple, after the tour groups have left. As the sun sinks lower, shadows spread across the courtyard. After sunset, the sky turns pink. The grey stone towers take on a golden color before turning pink. Nowhere else in the world can there be such a quiet, beautiful place.
Question: To clean the stone, how many steps should be followed?

Answer: three

Question: Context: Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor B ligand (RANKL) has been identified as a pivotal paracrine mediator of progesterone function in mouse mammary gland development and mammary carcinogenesis. Whether the factor has the same role in humans is of clinical interest because an inhibitor for RANKL, denosumab, is already used for the treatment of bone disease and might benefit breast cancer patients. We show that progesterone receptor (PR) signaling failed to induce RANKL in PR(+) breast cancer cell lines and in dissociated, cultured breast epithelial cells. In clinical specimens from healthy donors and intact breast tissue microstructures, hormone response was maintained and RANKL expression was under progesterone control, which increased RNA stability. RANKL was sufficient to trigger cell proliferation and was required for progesterone-induced proliferation. The findings were validated in vivo where RANKL protein expression in the breast epithelium correlated with serum progesterone levels and the protein was expressed in a subset of luminal cells that express PR. Thus, important hormonal control mechanisms are conserved across species, making RANKL a potential target in breast cancer treatment and prevention.
Question: To the ligand of which receptors does Denosumab (Prolia) bind?

Answer:
rankl