Teacher:In this task, you are given a abstract of article and corresponding title of an article. Your task is to generate label "yes" if title is right for article, otherwise generate "no".
Teacher: Now, understand the problem? Solve this instance: Abstract: Integrins, a large family of cell adhesion receptors, have been shown to play an important role for glioma proliferation and invasion. Several integrin receptors, including v3, v5, and 51, have generated clinical interest for glioma diagnosis and antitumor therapy. Integrin 51 has been highlighted as a prognostic and diagnostic marker in glioma, and its expression is correlated with a worse prognosis in high-grade glioma. However, unlike extensively studied integrins v3 and v5, very few integrin 51-specific radiotracers have been reported. Developing 51-specific radiotracers may provide alternative diagnosis and evaluation options in addition to well-studied v3/v5-specific tracers, and they may add new documents for profiling tumor progression. Here, a novel integrin 51-specific probe (99m)Tc-HisoDGR was fabricated for SPECT (single-photon emission computed tomography) imaging of glioma. To confirm its selective targeting of integrin 51 in vivo, the mouse models of 51-positive U87MG human glioma were subjected to SPECT/CT scans, and biodistribution experiments and blocking studies were performed. Small-animal SPECT/CT imaging experiments demonstrated that the tumors were clearly visualized in both subcutaneous and orthotopic glioma tumor models with clear background at 0.5, 1, and 2 h p.i. The tumor accumulation of (99m)Tc-HisoDGR showed significant reduction when excess cold isoDGR peptide was coinjected, suggesting that the tumor uptake was specifically mediated. Our work revealed that (99m)Tc-HisoDGR represented a powerful molecular probe for integrin 51-positive cancer imaging; moreover, it might be a promising tool for evaluating malignancy, predicting prognosis, selecting subpopulations of patients who might be sensitive to integrin 51-targeted drugs, and assessing and monitoring the response to integrin 51-targeted drugs in clinical trials.. Title: Metabolic modifiers as performance-enhancing technologies for livestock production
Student:
no