Although the number of base-pairs of DNA in the human genome has been known since the 1960s, the estimated number of genes has changed over time as definitions of genes, and methods of detecting them have been refined. Initial theoretical predictions of the number of human genes were as high as 2,000,000. Early experimental measures indicated there to be 50,000100,000 transcribed genes (expressed sequence tags). Subsequently, the sequencing in the Human Genome Project indicated that many of these transcripts were alternative variants of the same genes, and the total number of protein-coding genes was revised down to ~20,000 with 13 genes encoded on the mitochondrial genome. Of the human genome, only 12% consists of protein-coding genes, with the remainder being 'noncoding' DNA such as introns, retrotransposons, and noncoding RNAs.
Since when has the number of base pairs of DNA in the human genome been known?
the 1960s

After the fall of Napoleon, many alpine countries developed heavy protections to prevent any new invasion. Thus, Savoy built a series of fortifications in the Maurienne valley in order to protect the major alpine passes, such as the col du Mont-Cenis that was even crossed by, Charlemagne and his father to defeat the Lombarts. The later indeed became very popular after the construction of a paved road ordered by Napoleon Bonaparte. The Barriere de l'Esseillon is a serie of forts with heavy batteries, built on a cliff with a perfect view on the valley, a gorge on one side and steep mountains on the other side.
Who ordered the construction of a paved road?
Napoleon Bonaparte

For over 40 years, the FBI crime lab in Quantico believed lead in bullets had unique chemical signatures. It analyzed the bullets with the goal of matching them chemically, not only to a single batch of ammunition coming out of a factory, but also to a single box of bullets. The National Academy of Sciences conducted an 18-month independent review of comparative bullet-lead analysis. In 2003, its National Research Council published a report whose conclusions called into question 30 years of FBI testimony. It found the analytic model used by the FBI for interpreting results was deeply flawed, and the conclusion, that bullet fragments could be matched to a box of ammunition, was so overstated that it was misleading under the rules of evidence. One year later, the FBI decided to stop doing bullet lead analysis.
How long was the National Academy of Sciences independent review?
18-month