Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.

A: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
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Q: Microscopes, tools that you may get to use in your class, are some of the most important tools in biology ( Figure Microscopy is the study of small objects using microscopes. Look at your fingertips. Before microscopes were invented in 1595, the smallest things you could see on yourself were the tiny lines in your skin. But what else is hidden in your skin? Over four hundred years ago, two Dutch spectacle makers, Zaccharias Janssen and his son Hans, were experimenting with several lenses in a tube. They discovered that nearby objects appeared greatly enlarged, or magnified. This was the forerunner of the compound microscope and of the telescope. In 1665, Robert Hooke, an English natural scientist, used a microscope to zoom in on a piece of cork - the stuff that makes up the stoppers in wine bottles, which is made from tree bark. Inside of cork, he discovered tiny structures, which he called cells. It turns out that cells are the smallest structural unit of living organisms. This finding eventually led to the development of the theory that all living things are made of cells. Without microscopes, this discovery would not have been possible, and the cell theory would not have been developed. Hookes discovery of the cell set the stage for other scientists to discover other types of organisms. After Hooke, the "father of microscopy," Dutch scientist Antoine van Leeuwenhoek ( Figure 1.2) taught himself to make one of the first microscopes. In one of his early experiments, van Leeuwenhoek took a sample of scum from his own teeth and used his microscope to discover bacteria, the smallest living organism on the planet. Using microscopes, van Leeuwenhoek also discovered one-celled protists and sperm cells. Today, microscopes are used by all types of scientists, including cell biologists, microbiologists, virologists, forensic scientists, entomologists, taxonomists, and many other types. Antoine van Leeuwenhoek, a Dutch cloth merchant with a passion for microscopy. Some modern microscopes use light, as Hookes and van Leeuwenhoeks did. Others may use electron beams or sound waves. Researchers now use these four types of microscopes: 1. Light microscopes allow biologists to see small details of a specimen. Most of the microscopes used in schools and laboratories are light microscopes. Light microscopes use lenses, typically made of glass or plastic, to focus light either into the eye, a camera, or some other light detector. The most powerful light microscopes can make images up to 2,000 times larger. 2. Transmission electron microscopes (TEM) focus a beam of electrons through an object and can make an image up to two million times bigger, with a very clear image. 3. Scanning electron microscopes (SEM) allow scientists to find the shape and surface texture of extremely small objects, including a paperclip, a bedbug, or even an atom. These microscopes slide a beam of electrons across the surface of a specimen, producing detailed maps of the surface of objects. Magnification in a SEM can be controlled over a range from about 10 to 500,000 times. 4. Scanning acoustic microscopes use sound waves to scan a specimen. These microscopes are useful in biology and medical research. Scanning Electron Microscope at (5:04) Click image to the left or use the URL below. URL: 1. How is the electron beam focused? 2. What part of a specimen does a scanning electron microscope look at? 3. Why is it important that a specimen for an electron microscope be placed in a vacuum? Why is this step unnecessary for a light microscope?

A: who discovered single-celled protists?
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Q: To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis. Three multicenter, randomized, double-masked, placebo-controlled, dose-ranging phase III studies: SHIELD, INSURE, and ENDURE. A total of 118 patients with Behcet's uveitis (SHIELD study); 31 patients with active, noninfectious, non-Behcet's uveitis (INSURE study); and 125 patients with quiescent, noninfectious, non-Behcet's uveitis (ENDURE study) were enrolled. After an initial subcutaneous (s.c.) loading phase in each treatment arm, patients received s.c. maintenance therapy with secukinumab 300 mg every 2 weeks (q2w), secukinumab 300 mg monthly (q4w), or placebo in the SHIELD study; secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the INSURE study; or secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the ENDURE study. Reduction of uveitis recurrence or vitreous haze score during withdrawal of concomitant immunosuppressive medication (ISM). Other end points included best-corrected visual acuity, ISM use (expressed as a standardized ISM score), and safety outcomes. After completion or early termination of each trial, there were no statistically significant differences in uveitis recurrence between the secukinumab treatment groups and placebo groups in any study. Secukinumab was associated with a significant reduction in mean total post-baseline ISM score (P = 0.019; 300 mg q4w vs. placebo) in the SHIELD study. Likewise, secukinumab was associated with a greater median reduction in ISM score versus placebo in the INSURE study, although no statistical analysis of the difference was conducted because of the small sample size. Overall, there was no loss in visual acuity reported in any treatment group during follow-up in all 3 studies. According to descriptive safety statistics, the frequencies of ocular and nonocular adverse events seemed to be slightly higher among secukinumab groups versus placebo across the 3 studies. The primary efficacy end points of the 3 studies were not met. The secondary efficacy data from these studies suggest a beneficial effect of secukinumab in reducing the use of concomitant ISM.

A:
Which molecule is targeted by a monoclonal antibody Secukinumab?
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