In this task, you are given a question and answer options for that question. Using this information, you have to classify each text into different topics: medicine, nursery, psychology, chemistry, pharmacology, biology.

Question: Regarding gastroesophageal reflux disease, which of the following statements is true?
Options: <0> The intensity and frequency of heartburn has little relationship with the presence and severity of endoscopic esophagitis. <1> Most patients with gastroesophageal reflux disease have esophagitis at endoscopy. <2> Treatment with proton pump inhibitors usually achieves good control of symptoms but is not superior to placebo in the endoscopic cure of esophagitis. <3> Barrett's esophagus can progress to low-grade epithelial dysplasia, high-grade epithelial dysplasia, and finally squamous cell carcinoma of the esophagus. <4> Endoscopic screening and surveillance programs have unequivocally shown to be able to reduce mortality in patients with Barrett's esophagus.
medicine

Question: The content validity of an evaluation instrument refers to:
Options: <0> The evidence obtained by factor analysis. <1> The concurrence of measures. <2> The adequacy in the establishment of inferences. <3> The relevance and representativeness of its items. <4> The significant relationships with other measures.
psychology

Question: Somatomedin IGF-1 causes:
Options: <0> Secretion of GHRH. <1> Protein catabolism. <2> Hyperglycemia <3> Activation of osteoblasts <4> GH secretion
biology