Context and question: In music, popular local bands include The Five Stars, Penina o Tiafau and Punialava'a. The Yandall Sisters' cover of the song Sweet Inspiration reached number one on the New Zealand charts in 1974. King Kapisi was the first hip hop artist to receive the prestigious New Zealand APRA Silver Scroll Award in 1999 for his song Reverse Resistance. The music video for Reverse Resistance was filmed in Savai'i at his villages. Other successful Samoan hip hop artists include rapper Scribe, Dei Hamo, Savage and Tha Feelstyle whose music video Suamalie was filmed in Samoa.
What award did Penina o Tiafu recieve in 1999?
Answer: unanswerable
Context and question: In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.
What type of filing is used before beginning human trials?
Answer: Investigational New Drug
Context and question: Founded to preach the Gospel and to combat heresy, the teaching activity of the order and its scholastic organization placed the Preachers in the forefront of the intellectual life of the Middle Ages. The order is famed for its intellectual tradition, having produced many leading theologians and philosophers. The Dominican Order is headed by the Master of the Order, who is currently Bruno Cadore. Members of the order generally carry the letters O.P., standing for Ordinis Praedicatorum, meaning of the Order of Preachers, after their names.
During what time period did the Dominican Order do its best work?
Answer:
the Middle Ages