In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies. While natural killer (NK) cells can directly contribute to the control of viral replication, whether, and how, they may help orchestrate global antiviral defense is largely unknown. To address this question, we took advantage of the welldefined molecular interactions involved in the recognition of mouse cytomegalovirus (MCMV) by NK cells. By using congenic or mutant mice and wild-type versus genetically engineered viruses, we examined the consequences on antiviral CD8 T cell responses of specific defects in the ability of the NK cells to control MCMV. This system allowed us to demonstrate, to our knowledge for the first time, that NK cells accelerate CD8 T cell responses against a viral infection in vivo. Moreover, we identify the underlying mechanism as the ability of NK cells to limit IFN-a/b production to levels not immunosuppressive to the host. This is achieved through the early control of cytomegalovirus, which dramatically reduces the activation of plasmacytoid dendritic cells (pDCs) for cytokine production, preserves the conventional dendritic cell (cDC) compartment, and accelerates antiviral CD8 T cell responses. Conversely, exogenous IFN-a administration in resistant animals ablates cDCs and delays CD8 T cell activation in the face of NK cell control of viral replication. Collectively, our data demonstrate that the ability of NK cells to respond very early to cytomegalovirus infection critically contributes to balance the intensity of other innate immune responses, which dampens early immunopathology and promotes optimal initiation of antiviral CD8 T cell responses. Thus, the extent to which NK cell responses benefit the host goes beyond their direct antiviral effects and extends to the prevention of innate cytokine shock and to the promotion of adaptive immunity.
Title: Natural Killer Cells Promote Early CD8 T Cell Responses against Cytomegalovirus
Example Output: False

Example Input: Paragraph: Background: Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) might initiate effective host immune responses versus HBV to achieve functional cure of CHB. Methods: Two experimental mouse models that mice hydrodynamic injected HBV DNA or infected with recombinant AAV/HBV were used. The "sandwich" therapeutic effect by using a potent human anti-HBsAg neutralizing monoclonal antibody (G12) in combination with antiviral drug tenofovir disoproxil fumarate (TDF), followed by active immunization with HBsAg-HBsAb (mYIC) was evaluated. Findings: A single G12 injection rapidly cleared serum HBsAg in HDI-HBV carrier mice, with a synergistic effect in decreasing viral DNA load when TDF was given orally. When both serum viral DNA and HBsAg load became low or undetectable, mYIC was administered. A more effective clearance of viral DNA and HBsAg was observed and serum HBsAb was developed only in these "sandwich"-treated mice. Efficient intrahepatic anti-HBV immune responses were also observed in these mice, including the formation of aggregates of myeloid cells with CD8 + T cells and increased TNF-, granzyme B production. The "sandwich" combination therapy not only efficiently decreased HBsAg and HBV DNA levels but also induced effective cellular and humoral immunity, which may result in functional cure of CHB. Research in context section Persistence of HBV cccDNA and various host immune defects were shown as the two main obstacles for HBV clearance. Blocking a single target will not be sufficient to achieve functional cure of CHB. A very small percentage of CHB patients could attain "functional cure" by antiviral treatment fol- * Corresponding authors. .cn (Z. Yuan). lowed by interferon therapy. Therapeutic vaccination for CHB showed substantial efficacy. A humanized HBsAb G12 could efficiently block HBV infection and decrease HBsAg level in mice model. This research showed that when both serum viral DNA and HB-sAg load became low or undetectable by antiviral and HBsAb treatment, therapeutic vaccine (mYIC) add on induced effective, host humoral and intrahepatic cellular anti-HBV immune responses, with more rapid and efficient clearance of HBV and HBsAg. Based on optimized antiviral treatment with potent human HB-sAb to rapidly decrease serum HBsAg, followed by boosting host with active immunization provides a novel strategy for functional cure of CHB.
Title: Evaluation of antiviral -passive -active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice
Example Output: True

Example Input: Paragraph: This chapter discusses the concept of global health security, the key challenges it raises and the role of diplomacy in addressing them. It begins by outlining an expanded understanding of security, describing the concept of health security, including the dual aspects of societal health security and individual, or personal, health security. The political context is also described. Key issues in societal health security are then outlined, including signi fi cant threats and current responses. Threats covered include the emergence of infectious diseases that cross the species barrier from animals to humans, climate change, the deliberate use of disease-causing agents and the growing burden of non-communicable diseases. Current approaches to addressing threats to societal health security are discussed, along with the role to be played by international affairs. The chapter then describes key issues in individual health security, including reliable access to medicines and other health-related products and services; and the politically and economically sensitive determinants of access. The chapter then discusses how to ensure stronger global health security in the future. Security can no longer be narrowly de fi ned as the absence of military threat from another state, as it was in the days when Adam Smith wrote his treatise on the duties of a government (Smith 1776 ) . Health security -protection from threats to healthis now recognized as an important non-traditional security issue. The global impacts of pandemic s, the rise in counterfeit medicines, the role of health provision in postcon fl ict environments and the centrality of improving universal access to effective health care to economic development are all examples of the growing intersection between global health issues and other dimensions of human security . Health security as broadly de fi ned has both a societal and an individual aspect. At the societal level, global health security means reducing collective vulnerability to global public health threats, both immediate and gradual. These threats often go beyond or transcend borders and may be caused by infectious agents that emerge naturally at the human/animal interface, but they may also be caused by chemicals, toxins and radiation, or be deliberately caused by acts of terrorism. The steady and increasing rise in non-communicable diseases also constitutes a threat to societal health security . Moreover, reducing vulnerability means, not only combating the disease threats themselves but also addressing their determinants, some of which may also transcend borders, such as international trade and other economic policies that in fl uence the emergence and spread of disease. Health security-protection from threats to health-is an important human security issue. A series of emerging infectious diseases have challenged global health security and economic stability. Stronger health security requires an understanding of the determinants of infectious and non-communicable diseases and how and where intervention can decrease risks. Access to health care depends on a variety of factors ranging from effec- tiveness of health systems and the cost of medicines to the role of governments providing health care. The Oslo Ministerial Declaration stresses the convergence between foreign policy concerns for security and economic stability and global health issues. 127 9 Diplomacy and Global Health Security At the individual level, health security must include protection and provision measures such as access to safe and effective medicines, vaccines and medical care. Increasing personal health security thus means providing individuals with more sustained-and therefore secure-access to quality medical goods and services. Policies and strategies that are developed to address health security issues arise within a broad political context. Governance and policies in sectors outside health, such as agriculture, trade, fi nance, national security or defence, can have signi fi cant effects on health outcomes. Likewise, action aimed at improving health security can affect other sectors. For these reasons, when health security issues involve trans-border events and become international, they can encounter serious dif fi culties in bilateral relations, at international organizations and in diplomatic negotiations because of a divergence of political, economic or social interests among states, and between states and non-state actors. As examples: efforts to combat counterfeit, falsi fi ed and substandard medicines-which pose a signi fi cant danger to healthhave been hampered by the lack of a consensus de fi nition of counterfeit as it pertains to medicines. This in turn risks becoming embroiled in controversy over which institutions should have how much authority over the problem because issues other than health protection, such as trade, intellectual property and the fi ght against organized crime, are also at stake. To enable medicines and vaccines to reach those who need them, it is often necessary to address barriers such as trade, regulations and intellectual property rights. Responses to the threat or consequences of chemical and biological terrorism must involve not only public health but also national and international security and crime prevention agencies. Health security is an important foreign policy and diplomatic concern that is both in fl uenced by and affects decisions on national security, economic well-being, international development strategies and the protection of human dignity. Finding sustainable solutions to global needs in health security thus requires better understanding and collaboration between the international affairs and global health communities to achieve effective policies.
Title: Diplomacy and Global Health Security Introduction: What Is Global Health Security and the Role of Diplomacy?
Example Output:
False