Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: The original construction permit for the station was granted on July 1, 1983, and the WLKZ call letters were assigned on October 11; it took to the air on February 1, 1985, and a license to cover was granted on June 4, 1985.
Example Output: What is year of inception of WLKZ?

Example Input: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.
Example Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Example Input: The urinary system controls the amount of water in the body and removes wastes. Any problem with the urinary system can also affect many other body systems. In some cases, certain mineral wastes can form kidney stones ( Figure 1.1). Stones form in the kidneys and may be found anywhere in the urinary system. Often, stones form when the urine becomes concentrated, allowing minerals to crystallize and stick together. They can vary in size, from small stones that can flow through your urinary system, to larger stones that cannot. Some stones cause great pain, while others cause very little pain. Some stones may need to be removed by surgery or ultrasound treatments. What are the symptoms of kidney stones? You may have a kidney stone if you have pain while urinating, see blood in your urine, and/or feel a sharp pain in your back or lower abdomen (the area between your chest and hips). The pain may last for a long or short time. You may also have nausea and vomiting with the pain. If you have a small stone that passes on its own easily, you may not experience any symptoms. If you have some of these symptoms, you should see your doctor. A kidney stone. The stones can form anywhere in the urinary system. Kidney failure happens when the kidneys cannot remove wastes from the blood. If the kidneys are unable to filter wastes from the blood, the wastes build up in the body. Kidney failure can be caused by an accident that injures the kidneys, the loss of a lot of blood, or by some drugs and poisons. Kidney failure may lead to permanent loss of kidney function. But if the kidneys are not seriously damaged, they may recover. Chronic kidney disease is the slow decrease in kidney function that may lead to permanent kidney failure. A person who has lost kidney function may need to get kidney dialysis. Kidney dialysis is the process of filtering the blood of wastes using a machine. A dialysis machine ( Figure 1.2) filters waste from the blood by pumping the blood through a fake kidney. The filtered blood is then returned to the patients body. Urinary tract infections (UTIs) are bacterial infections of any part of the urinary tract. When bacteria get into the bladder or kidney and produce more bacteria in the urine, they cause a UTI. The most common type of UTI is a bladder infection. Women get UTIs more often than men. UTIs are often treated with antibiotics. Most UTIs are not serious, but some infections can lead to serious problems. Long lasting kidney infections can cause permanent damage, including kidney scars, poor kidney function, high blood pressure, and other problems. Some sudden kidney infections can be life threatening, especially if the bacteria enter the bloodstream, a condition called septicemia. What are the signs and symptoms of a UTI? a burning feeling when you urinate, frequent or intense urges to urinate, even when you have little urine to pass, pain in your back or side below the ribs, cloudy, dark, bloody, or foul-smelling urine, fever or chills. You should see your doctor if you have signs of a UTI. Your doctor will diagnose a UTIs by asking about your symptoms and then testing a sample of your urine.
Example Output:
the most common type of uti is