TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is kREX2 essential for either procyclic or bloodstream form Trypanosoma brucei?
Answer: KREX2 is a U-specific exonuclease that is dispensable for RNA editing in vivo in T. brucei BFs and PFs. This result suggests that the U deletion activity, which is required for RNA editing, is primarily mediated in vivo by KREX1 which is normally found associated with only one type of editosome. The retention of the KREX2 gene implies a non-essential role or a role that is essential in other life cycle stages or conditions.

SOLUTION: no

PROBLEM: Question: Does myeloid knockout of HIF-1 markedly affect hemorrhage/resuscitation-induced inflammation and hepatic injury?
Answer: Here, deleting HIF-1 in myeloid cells and thereby in Kupffer cells was not protective after H/R. This data indicates that other factors, such as NF- B, due to its upregulated phosphorylation in WT and KO mice, contrary to HIF-1 , are rather key modulators of inflammation after H/R in our model.

SOLUTION: no

PROBLEM: Question: Is actinic keratosis with atypical basal cells ( AK I ) the most common lesion associated with invasive squamous cell carcinoma of the skin?
Answer: Direct invasion from proliferating basaloid atypical keratinocytes limited to the epidermal basal layer (AK I), known as the differentiated pathway, was the most common form of progression to cutaneous iSCC in our series. On the other hand, stepwise progression from AK I to AK II and AK III (classic pathway) was seen to be operative in a substantial proportion of iSCC cases. All AK lesions, irrespective of intraepidermal neoplasia thickness, are therefore potentially invasive and tumour advance along adnexal structures might facilitate iSCC development from AK I lesions.

SOLUTION:
yes