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How to replace a bicycle tire
Loosen the nuts that hold the axle to the frame.
If they are extremely tight, spray some lubricant on the nuts-a silicone lubricant or even vegetable oil will do the trick very well. ( many modern bikes will not have nuts.
They have a quick-release which you can easily loosen and remove the wheel). Release the brakes if your bike is equipped with them and they interfere with wheel removal.