The Bears fought to continue their playoff chances against the Arizona Cardinals, with a loss knocking the Bears out of contention. Jay Cutler began the game having his first six passes fall incomplete, though he ended the game completing 12 of 26 for 146 yards and a touchdown. The Bears started the game on a strong note when Cardinals running back Beanie Wells fumbled the ball, and was recovered by Zack Bowman in the end zone, giving the Bears the lead. Arizona then settled for Jay Feely's 49-yard field goal. On the following drive, Matt Forte broke free for a 36-yard run, followed by Brandon Marshall's 30-yard catch reaching the Cardinals 4-yard line, where Forte ran in untouched to increase the score to 14-3. The Cardinals later tried a fake field goal instead of attempting a 50-yard field goal, but failed. Later in the game, D. J. Moore muffed Dave Zastudil's punt, which was recovered by Arizona's Michael Adams. However, the Cardinals were only able to get a field goal. On Chicago's final possession of the first half, Cutler completed all of his passes, and the Bears scored on Cutler's 11-yard pass to Marshall. In the second half, Charles Tillman intercepted Ryan Lindley, and had the pick returned 10-yards for a touchdown. The interception return is the eighth by the team, one shy of the NFL record. Lindley was later replaced by Brian Hoyer, who was also ineffective, having a pass intercepted by Kelvin Hayden, who took it 39 yards to the Arizona 10. The Bears failed to take advantage of the interception, as Olindo Mare's field goal was blocked by Adrian Wilson, which was recovered by Justin Bethel, who returned the blocked kick 82 yards for the Cardinals lone touchdown. With the win, the Bears kept their playoff hopes alive, as their record improved to 9-6. In order for the Bears to qualify for the playoffs, they must defeat the Lions in Week 17, while having the Packers defeat the Vikings.

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