In this task, you are given an abstract of article. Your task is to generate title for this article. Preferred titles are under thirty words.
Q: We developed a novel mouse model of malignant pleural effusion (MPE) by injecting Lewis lung cancer (LLC) cells directly into the pleural space of syngeneic C57B/6 mice. The pleural effusions in this model share common cellular and biochemical features with human MPEs. Implantation and growth of pleural tumors triggers a host inflammatory response characterized by a mixed inflammatory cell influx into the pleural fluid. LLC cells exhibited high basal nuclear factor (NF)-B activity in vitro and in vivo, which we used to drive expression of a NF-Bdependent green fluorescent protein-firefly luciferase fusion reporter construct. NF-Bdependent reporter expression allowed intravital tracing of pleural tumors. Inhibition of NF-B in LLC cells did not affect cell viability in culture; however, injection of LLC cells expressing a dominant NF-B inhibitor resulted in decreased tumor burden, decreased pleural effusion volume, and decreased pleural effusion TNF- levels. These studies indicate that tumor NF-B a...
A:
Nuclear Factor-B Affects Tumor Progression in a Mouse Model of Malignant Pleural Effusion