Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: The Stadion pod Dubnom is an all-seater football stadium situated in Zilina, Slovakia, which is the home of MSK Zilina.
Example Output: What team uses Stadion pod Dubnom?

Example Input: Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.
Example Output: Which enzyme is inhibited by a drug fostamatinib?

Example Input: Did you know that you see the largest organ in your body every day? You wash it, dry it, cover it up to stay warm, and uncover it to cool off. Yes, your skin is your bodys largest organ. Your skin is part of your integumentary system ( Figure 1.1), which is the outer covering of your body. The integumentary system is made up of your skin, hair, and nails. Skin acts as a barrier that stops water and other things, like soap and dirt, from getting into your body. The skin has many important functions. The skin: Provides a barrier. It keeps organisms that could harm the body out. It stops water from entering or leaving the body. Controls body temperature. It does this by making sweat (or perspiration), a watery substance that cools the body when it evaporates. Gathers information about your environment. Special nerve endings in your skin sense heat, pressure, cold, and pain. Helps the body get rid of some types of waste, which are removed in sweat. Acts as a sun block. A pigment called melanin blocks sunlight from getting to deeper layers of skin cells, which are easily damaged by sunlight. Your skin is always exposed to your external environment, so it gets cut, scratched, and worn down. You also naturally shed many skin cells every day. Your body replaces damaged or missing skin cells by growing more of them. Did you know that the layer of skin you can see is actually dead? As the dead cells are shed or removed from the upper layer, they are replaced by the skin cells below them. Two different layers make up the skin: the epidermis and the dermis ( Figure 1.2). A fatty layer lies under the dermis, but it is not part of your skin. The epidermis is the outermost layer of the skin. It forms the waterproof, protective wrap over the bodys surface. Although the top layer of epidermis is only about as thick as a sheet of paper, it is made up of 25 to 30 layers of cells. The epidermis also contains cells that produce melanin. Melanin is the brownish pigment that gives skin and hair their color. Melanin-producing cells are found in the bottom layer of the epidermis. The epidermis does not have any blood vessels. The lower part of the epidermis receives blood by diffusion from blood vessels of the dermis. Skin is made up of two layers, the epider- mis on top and the dermis below. The tissue below the dermis is called the hy- podermis, but it is not part of the skin. The dermis is the layer of skin directly under the epidermis. It is made of a tough connective tissue. The dermis contains hair follicles, sweat glands, oil glands, and blood vessels ( Figure 1.2). It also holds many nerve endings that give you your sense of touch, pressure, heat, and pain. Do you ever notice how your hair stands up when you are cold or afraid? Tiny muscles in the dermis pull on hair follicles which cause hair to stand up. The resulting little bumps in the skin are commonly called "goosebumps" ( Figure 1.3). Glands and hair follicles open out into the epidermis, but they start in the dermis. Oil glands ( Figure 1.2) release, or secrete an oily substance, called sebum, into the hair follicle. Sebum waterproofs hair and the skin surface to prevent them from drying out. It can also stop the growth of bacteria on the skin. It is odorless, but the breakdown of sebum by bacteria can cause odors. If an oil gland becomes plugged and infected, it develops into a pimple. Up to 85% of teenagers get pimples, which usually go away by adulthood. Frequent washing can help decrease the amount of sebum on the skin. Sweat glands ( Figure 1.2) open to the skin surface through skin pores. They are found all over the body. Evaporation of sweat from the skin surface helps to lower skin temperature. The skin also releases excess water, salts, sugars, and other wastes, such as ammonia and urea,
Example Output:
how does skin act as a sun block?