Detailed Instructions: In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.
Problem:Context: To determine the role of NOTCH during the arterial injury response and the subsequent chronic arterial-wall inflammation underlying atherosclerosis.', 'We have generated a mouse model of endothelial-specific (Cdh5-driven) depletion of the Notch effector recombination signal binding protein for immunoglobulin kappa J region (RBPJ) [(ApoE\Question: Does endothelial Jag1-RBPJ signalling promote inflammatory leucocyte recruitment and atherosclerosis?
Solution:
Notch signalling pathway inactivation decreases leucocyte rolling, thereby preventing endothelial dysfunction and vascular inflammation. Attenuation of Notch signalling might provide a treatment strategy for atherosclerosis.