Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Despite significant progresses in the last decades, the origin of this cancer remains unclear and no efficient therapy exists. PDAC does not arise de novo: three remarkable different types of pancreatic lesions can evolve towards pancreatic cancer. These precursor lesions include: Pancreatic intraepithelial neoplasia (PanIN) that are microscopic lesions of the pancreas, Intraductal Papillary Mucinous Neoplasms (IPMN) and Mucinous Cystic Neoplasms (MCN) that are both macroscopic lesions. However, the cellular origin of these lesions is still a matter of debate. Classically, neoplasm initiation or progression is driven by several genetic and epigenetic alterations. The aim of this review is to assemble the current information on genetic mutations and epigenetic disorders that affect genes during pancreatic carcinogenesis. We will further discuss the interest of the genetic and epigenetic alterations for the diagnosis and prognosis of PDAC. Large genetic alterations (chromosomal deletion/amplification) and single point mutations are well described for carcinogenesis inducers. Mutations classically occur within key regions of the genome. Consequences are various and include activation of mitogenic pathways or silencing of apoptotic processes. Alterations of K-RAS, P16 and DPC4 genes are frequently observed in PDAC samples and have been described to arise gradually during carcinogenesis. DNA methylation is an epigenetic process involved in imprinting and X chromosome inactivation. Alteration of DNA methylation patterns leads to deregulation of gene expression, in the absence of mutation. Both genetic and epigenetic events influence genes and non-coding RNA expression, with dramatic effects on proliferation, survival and invasion. Besides improvement in our fundamental understanding of PDAC development, highlighting the molecular alterations that occur in pancreatic carcinogenesis could provide new clinical tools for early diagnosis of PDAC and the molecular basis for the development of new effective therapies.
Question: Which is the molecular mechanism underlying K-ras alterations in carcinomas?
point mutations

Context: Ant & Dec are an English comedy TV presenting duo, consisting of Anthony McPartlin OBE and Declan Donnelly OBE , from Newcastle upon Tyne, England. Formed after their meeting as actors on CBBC's drama, Byker Grove, the duo have led successful careers as television presenters, with hosting credits including SMTV Live, CD:UK, Friends Like These, Pop Idol, Ant & Dec's Saturday Night Takeaway, I'm a Celebrity...Get Me Out of Here!, PokerFace, Push the Button, Britain's Got Talent, Red or Black?, and Text Santa. Due to a difference in height - Ant being the taller at 5ft 8in , and Dec being two inches shorter at 5ft 6in - the pair identify themselves in the media by adopting the use of the 180-degree rule, with the exception of some early publicity shots. In addition to presenting, the duo are accomplished actors - both had leading roles in the 2006 film Alien Autopsy - operate as television producers - they own their own production company, Mitre Television - have presented the annual Brit Awards in 2001, 2015 and 2016, and are former pop musicians who operated under the aliases of their characters from Byker Grove. In a 2004 poll for the BBC, Ant & Dec were named the eighteenth most influential people in British culture.
Question: Who is the "Ant" in Ant & Dec?
anthony mcpartlin

Context: Simon Miller (Loren Dean) outwardly appears to be a geologist who must frequently take business trips, which has strained the relationship with his family, including his wife Meredith (Robyn Lively) and teenage children Sarah (Skyler Day) and Kevin (Drew Koles). When Simon suddenly goes missing, his family searches his office and discovers several passports, each with different aliases. They soon learn that Simon was in fact a spy who kept his true career secret from them. Simon mysteriously calls home and warns his family not to tell anyone about his disappearances, then abruptly hangs up. His family begins a search for Simon, which takes them to locations around the world. Sarah, an honor student, uses her foreign language skills to help, and Kevin uses his knowledge of technology.[1] They receive assistance from Amanda (Christine Baranski), another covert operative who initially appears to be a friend, but appears to have her own motives.[2]
Question: What is Simon Miller's job?
geologist