Definition: In this task, you are given an abstract of article. Your task is to generate label "True" if abstract is structured, otherwise generate "False". A structured abstract is composed of a topic sentence (or key sentence), relevant supporting sentences, and a closing (or transition) sentence. This structure is key to keeping your abstract focused on the main idea and creating a clear and concise image.
Input: The T-cell receptor (TCR) consists of a TCR heterodimer, a TCR homodimer, and CD3 and CD3 heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3 binds to the plasma membrane through a basic residue-rich stretch (BRS) and proposed that dissociation from the membrane is required for phosphorylation thereof. In this report we show that BRS motifs within the cytoplasmic tail of TCR mediate association with the plasma membrane and that TCR engagement results in TCR dissociation from the membrane. This dissociation requires phosphorylation of the TCR immunoreceptor tyrosine-based activation motifs by lymphocyte cell-specificprotein tyrosine kinase (Lck) but not -chain-associated protein kinase 70 binding. Mutations of the TCR BRS motifs that disrupt this membrane association attenuate proximal and distal responses induced by TCR engagement. These mutations appear to alter the localization of TCR with respect to Lck as well as the mobility of the TCR complex. This study reveals that tyrosine phosphorylation of the TCR cytoplasmic domain regulates its association with the plasma membrane and highlights the functional importance of TCR BRS motifs.
Output:
False