In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: To date, an effective therapeutic treatment that confers strong attenuation toward coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs is considered to be one of the most important. Here, we first present the structure of the full-length Nsp13 helicase of SARS-CoV (SARS-Nsp13) and investigate the structural coordination of its five domains and how these contribute to its translocation and unwinding activity. A translocation model is proposed for the Upf1like helicase members according to three different structural conditions in solution characterized through H/D exchange assay, including substrate state (SARS-Nsp13-dsDNA bound with AMPPNP), transition state (bound with ADP-AlF 4 ) and product state (bound with ADP). We observed that the 19-20 loop on the 1A domain is involved in unwinding process directly. Furthermore, we have shown that the RNA dependent RNA polymerase (RdRp), SARS-Nsp12, can enhance the helicase activity of SARS-Nsp13 through interacting with it directly. The interacting regions were identified and can be considered common across CoVs, which provides new insights into the Replication and Transcription Complex (RTC) of CoVs.
Title: Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

A: True
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Q: Paragraph: Research on respiratory protection against biologic agents is important to address major concerns such as occupational safety and terrorist attack. This review describes the literature on respiratory protection against bioaerosols and identifies research gaps. Respiratory protection is a complex field involving a number of factors, such as the efficiency of respirator filter material; facepiece fitting; and maintenance, storage, and reuse of respirators. Several studies used nonpathogenic microorganisms having physical characteristics similar to that of Mycobacterium tuberculosis to analyze microbial penetration through respirators. Some studies showed that high-efficiency particulate air (HEPA) and N95 filters provided a higher level of protection than dust/mist (DM) and dust/mist/fume (DMF) filters. Flow rate and relative humidity appear to alter the level of penetration of microorganisms through respirator filters. The relationship between microbial penetration through respirator filters and the aerodynamic diameter, length, or other physical characteristics of microorganisms remains controversial. Whether reaerosolization of bioaerosol particles should be a concern is unclear, given the fact that one study has demonstrated significant reaerosolization of 1-to 5-mm particles loaded onto respirator filters. Respirator maintenance, storage, and decontamination are important factors to be considered when reusing respirators. The respiratory protection against biologic warfare agents such as anthrax in military and civilian situations is described. (Am J Infect Control 2004;32:345-54.)
Title: Respiratory protection against bioaerosols: Literature review and research needs

A: False
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Q: Paragraph: The CPK cells derived from swine kidney were infected with the attenuated TO-163 strain of transmissible gastroenteritis (TGE) virus, and fused with uninfected Vero cells in the presence of polyethylene glycol. Repeated cocultivafion of the fused cells with uninfected Vero cells rendered the virus to grow in Vero cells. The Vero cell-adapted virus acquired the ability to infect and produce cytopathic effects in several other non-permissive cell lines of nonporcine origin. No major differences in viral polypeptides were shown between the Vero cell-adapted TO-163 strain and its parent strain by indirect immunofluorescence and Western blotting using monoclonal and polyclonal antibodies to TGE virus. Transmissible gastroenteritis (TGE) virus is a coronavirus with an envelope and positive strand RNA genome. The virion contains 3 structural proteins, i.e., peplomer (S or E 2), transmembrane (M or E 1), and nucleocapsid (N) [4] . The virus replicates predominantly in villous epithelial cells of the small intestines, and results in diarrhea in infected pigs [11, 17] . Although clinical symptoms are not clearly demonstrated, the respiratory tract and the tonsils are also susceptible to infection [3, 8, 15] . The host range of TGE virus is restricted like the other coronaviruses [16], and for the propagation of the virus, swine cell cultures are commonly used, although canine [12] and feline [6] cell cultures are less often used. An attempt was made to adapt TGE virus to Vero cells non-permissive to TGE virus infection. The CPK cells derived from swine kidney [10] were inoculated with the avirulent TO-163 strain of TGE virus [5], at a multiplicity of infection of 10, and incubated at 37 C for 18 h. The infected cells were fused
Title: Adaptation of transmissible gastroenteritis virus to growth in non-permissive Vero cells Brief Report

A:
True
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