Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Abstract: The relationship between the perfusion flow rate and cerebral oxygen consumption during deep hypothermic cardiopulmonary bypass at 20 degrees C was investigated in dogs. In 10 dogs the perfusion flow rate was decreased in steps from 100 to 60, 30, and 15 ml/kg/min every 30 minutes. Although cerebral blood flow decreased as perfusion flow rate decreased, the ratio of cerebral blood flow to the perfusion flow rate increased significantly (p less than 0.05) at a perfusion flow rate of 15 ml/kg/min compared to that at a perfusion flow rate of 100 or 60 ml/kg/min. The arterial-sagittal sinus blood oxygen content difference increased as perfusion flow rate decreased. Consequently, cerebral oxygen consumption did not vary significantly at perfusion flow rates of 100 (0.48 +/- 0.10), 60 (0.43 +/- 0.14), and 30 ml/kg/min (0.44 +/- 0.12 ml/100 gm/min), and it decreased significantly to 0.31 +/- 0.22 ml/100 gm/min at a perfusion flow rate of 15 ml/kg/min. In five dogs the perfusion flow rate was decreased in one step from 100 to 15 ml/kg/min, and after 60 minutes' perfusion at a perfusion flow rate of 15 ml/kg/min, the perfusion flow rate was returned to 100 ml/kg/min. Cerebral oxygen consumption decreased significantly during 60 minutes' perfusion at a perfusion flow rate of 15 ml/kg/min and did not return to its initial value after the perfusion flow rate was returned to 100 ml/kg/min. These data indicate that the optimal perfusion flow rate for the brain during deep hypothermic cardiopulmonary bypass at 20 degrees C appears to be 30 ml/kg/min, with a possible oxygen debt in the brain resulting in anaerobic metabolism if the perfusion flow rate is kept at 15 ml/kg/min or less.
Which is the apt title for the abstract? option1: Optimal perfusion flow rate for the brain during deep hypothermic cardiopulmonary bypass at 20 degrees C. An experimental study. option2: Buried transverse abdominal myocutaneous flap and silicone implants to reconstruct pectus excavatum and bilateral mastectomy deformity.
Optimal perfusion flow rate for the brain during deep hypothermic cardiopulmonary bypass at 20 degrees C. An experimental study.

Abstract: Norepinephrine concentrations and tyrosine hydroxylase activity were determined in the brains of moderate-seizure and severe-seizure genetically epilepsy-prone rats (GEPRs) and in nonepileptic control rats. Both moderate-seizure (GEPR-3) and severe-seizure (GEPR-9) animals had widespread abnormalities in brain norepinephrine concentrations. Abnormalities in tyrosine hydroxylase activity were restricted to the midbrain. The state of abnormal seizure susceptibility, but not severity, in the GEPR may be determined by noradrenergic deficits in the hypothalamus/thalamus. Both seizure severity and susceptibility may be determined by noradrenergic deficits in the telencephalon, midbrain, and pons-medulla. Seizure severity but not susceptibility may be determined by noradrenergic abnormalities in the cerebellum.
Which is the apt title for the abstract? option1: Indices of noradrenergic function in the central nervous system of seizure-naive genetically epilepsy-prone rats. option2: Psychogenic upper airway obstruction presenting as refractory wheezing.
Indices of noradrenergic function in the central nervous system of seizure-naive genetically epilepsy-prone rats.

Abstract: Double filtration plasmapheresis (DFPP) is a technique devised in an attempt to selectively remove pathogenetic macromolecules such as antibodies, immune complexes or viscosity-increasing substances directly from blood. In order to realize the differential filtration principle, two filters, one for separation of plasma and another for fractionation of plasma components, are installed in an extracorporeal circulation line. Selective separation of the plasma components is dependent on the filtration property of the two filters. Clinical experiences evidence the usefulness of this technique in regard to conservation of human blood products for supplementation.
Which is the apt title for the abstract? option1: Selective removal of pathogenetic macromolecules directly from whole blood by double filtration technique. option2: Leads from the MMWR. Trends in mortality from cirrhosis and alcoholism--United States, 1945-1983.
Selective removal of pathogenetic macromolecules directly from whole blood by double filtration technique.