Input: Article: In 1896, Patrick and Gilbert observed that during a prolonged period of sleep deprivation, sleepiness increases and decreases with a period of approximately 24 hours. In 1918, J.S. Szymanski showed that animals are capable of maintaining 24-hour activity patterns in the absence of external cues such as light and changes in temperature. In the early 20th century, circadian rhythms were noticed in the rhythmic feeding times of bees. Extensive experiments were done by Auguste Forel, Ingeborg Beling, and Oskar Wahl to see whether this rhythm was due to an endogenous clock.[citation needed] Ron Konopka and Seymour Benzer isolated the first clock mutant in Drosophila in the early 1970s and mapped the "period" gene, the first discovered genetic determinant of behavioral rhythmicity. Joseph Takahashi discovered the first mammalian circadian clock mutation (clock19) using mice in 1994. However, recent studies show that deletion of clock does not lead to a behavioral phenotype (the animals still have normal circadian rhythms), which questions its importance in rhythm generation.

Now answer this question: Who noticed that sleepiness increases and decreases in a 24 hour period?

Output: Patrick and Gilbert

Input: Article: The 1469 marriage of Isabella I of Castile and Ferdinand II of Aragon and the 1479 death of John II of Aragon led to the creation of modern-day Spain. In 1492, Granada was captured from the Moors, thereby completing the Reconquista. Portugal had during the 15th century particularly under Henry the Navigator gradually explored the coast of Africa, and in 1498, Vasco da Gama found the sea route to India. The Spanish monarchs met the Portuguese challenge by financing the expedition of Christopher Columbus to find a western sea route to India, leading to the discovery of the Americas in 1492.

Now answer this question: When was modern-day Spain created?

Output: 1492

Input: Article: Service dogs such as guide dogs, utility dogs, assistance dogs, hearing dogs, and psychological therapy dogs provide assistance to individuals with physical or mental disabilities. Some dogs owned by epileptics have been shown to alert their handler when the handler shows signs of an impending seizure, sometimes well in advance of onset, allowing the guardian to seek safety, medication, or medical care.

Now answer this question: Early warning allows epileptics to get to safety, get medication or what else?

Output:
medical care.