Detailed Instructions: Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.
Q: Evidence has emerged indicating that the 4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD.", 'The aim of this study was to investigate interaction effects of the APOE 4 allele and the alleles at the single-nucleotide polymorphism rs3851179 located in the PICALM locus. We analyzed brain volumes and cognitive phenotypes of 165 patients with early AD dementia.', 'There was a synergistic adverse effect of homozygosity for the PICALM risk allele G in rs3851179 and APOE 4 on volume in prefrontal and performance on the Trail Making Test A, which is sensitive to processing speed and working memory function.
A:
0