In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Q: binds to angiotensin-converting enzyme 2 which serves as a cellular receptor. Epidemiological analysis of a hospital outbreak in Hong Kong revealed that blood group O was associated with a low risk of infection. In this study, we used a cellular model of adhesion to investigate whether natural antibodies of the ABO system could block the S protein and angiotensin-converting enzyme 2 interaction. To this aim, a C-terminally EGFP-tagged S protein was expressed in chinese hamster ovary cells cotransfected with an 1,2fucosyltransferase and an A-transferase in order to coexpress the S glycoprotein ectodomain and the A antigen at the cell surface. We observed that the S protein/angiotensinconverting enzyme 2-dependent adhesion of these cells to an angiotensin-converting enzyme 2 expressing cell line was specifically inhibited by either a monoclonal or human natural anti-A antibodies, indicating that these antibodies may block the interaction between the virus and its receptor, thereby providing protection. In order to more fully appreciate the potential effect of the ABO polymorphism on the epidemiology of SARS, we built a mathematical model of the virus transmission dynamics that takes into account the protective effect of ABO natural antibodies. The model indicated that the ABO polymorphism could contribute to substantially reduce the virus transmission, affecting both the number of infected individuals and the kinetics of the epidemic. 1085 P Guillon et al.

A: Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies
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Q: Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a novel single-stranded, positive-sense RNA betacoronavirus (MERS-CoV). Dromedary camels, hosts for MERS-CoV, are implicated in direct or indirect transmission to human beings, although the exact mode of transmission is unknown. The virus was fi rst isolated from a patient who died from a severe respiratory illness in June, 2012, in Jeddah, Saudi Arabia. As of May 31, 2015, 1180 laboratory-confi rmed cases (483 deaths; 40% mortality) have been reported to WHO. Both community-acquired and hospital-acquired cases have been reported with little human-to-human transmission reported in the community. Although most cases of MERS have occurred in Saudi Arabia and the United Arab Emirates, cases have been reported in Europe, the USA, and Asia in people who travelled from the Middle East or their contacts. Clinical features of MERS range from asymptomatic or mild disease to acute respiratory distress syndrome and multiorgan failure resulting in death, especially in individuals with underlying comorbidities. No specifi c drug treatment exists for MERS and infection prevention and control measures are crucial to prevent spread in health-care facilities. MERS-CoV continues to be an endemic, low-level public health threat. However, the virus could mutate to have increased interhuman transmissibility, increasing its pandemic potential.

A: Seminar Middle East respiratory syndrome
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Q: The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga genus. This type of triterpenoid glycoside possesses several important biological activities. More than 120 cycloartane triterpene glycosides have been isolated from Cimicifuga simplex Wormsk. The aim of this review article is to summarize all the major findings based on the available scientific literatures on C. simplex, with a focus on the identified 9,19-cyclolanostane triterpenoid glycosides. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed. Cimicifuga simplex; Ranunculaceae; Cycloartenol triterpenoid saponins; Biological effects [CLC Number] R284, R965 [Document code] A [Article ID] These authors have no any conflict of interest to declare. Published by Elsevier B.V. All rights reserved and biological perspectives. C. simplex, also known as Ku lou ya gen and Long yan gen, is an important species in the original Chinese drug Shengma. In Chinese traditional medicine, as along with other Cimicifuga species, it has been used to clear heat, relieve toxicity, disperse exterior pathogen, promote eruption, and lift spirit [3] . Plant-based formulations for various medicinal applications use different preparation methods, including powders, alcohol extracts, water extracts, and honey processed pills. The roots of C. simplex have been used to treat headache, toothache, aphtha, sore throat, measles, rectocele, and uterine prolapse [11] . The most important biologically active components of C. simplex are the cycloartenol triterpenoid saponins which have good immunosuppressive activities [12] . C. simplex Wormsk. ex DC. (Shengma in Chinese) is a deciduous perennial herb, and is widely distributed in China [13] . Currently, more than 120 cycloartane-type triterpenoids from Cimicifuga simplex have been isolated by several groups [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] , including compounds of cycloartanol type, 16,23-dione type, shengmanol type, hydroshengmanol type, cimifugenin type, cimiacerogenin type, and the cimigenol type. The chemical structures of these cycloartenol triterpenoid saponins are shown in Fig.s 17 and are listed in Table 1 . The isolation scheme WU Lun, et al. / Chin J Nat Med, 2015, 13(2): 8189 -82 -for the 9,19-cyclolanostane triterpenoid glycosides from C. simplex is shown in Fig. 8 .

A:
Cycloartenol triterpenoid saponins from Cimicifuga simplex (Ranunculaceae) and their biological effects
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