psui3905/ncbi_genes_summary huggingface dataset:
PRKAA2, Official Symbol PRKAA2provided by HGNC Official Full Name protein kinase AMP-activated catalytic subunit alpha 2provided by HGNC Primary source HGNC:HGNC:9377 See related Ensembl:ENSG00000162409 MIM:600497; AllianceGenome:HGNC:9377 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMPK; AMPK2; PRKAA; AMPKa2 Summary The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 14.0), kidney (RPKM 6.8) and 8 other tissues See more Orthologs mouse all
PRKAB1, Official Symbol PRKAB1provided by HGNC Official Full Name protein kinase AMP-activated non-catalytic subunit beta 1provided by HGNC Primary source HGNC:HGNC:9378 See related Ensembl:ENSG00000111725 MIM:602740; AllianceGenome:HGNC:9378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMPK; HAMPKb Summary The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 25.5), bone marrow (RPKM 15.9) and 25 other tissues See more Orthologs mouse all
PRKAB2, Official Symbol PRKAB2provided by HGNC Official Full Name protein kinase AMP-activated non-catalytic subunit beta 2provided by HGNC Primary source HGNC:HGNC:9379 See related Ensembl:ENSG00000131791 MIM:602741; AllianceGenome:HGNC:9379 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in duodenum (RPKM 16.7), liver (RPKM 11.0) and 25 other tissues See more Orthologs mouse all
PRKACA, Official Symbol PRKACAprovided by HGNC Official Full Name protein kinase cAMP-activated catalytic subunit alphaprovided by HGNC Primary source HGNC:HGNC:9380 See related Ensembl:ENSG00000072062 MIM:601639; AllianceGenome:HGNC:9380 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAFD1; PKACA; PPNAD4 Summary This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in heart (RPKM 62.0), adrenal (RPKM 43.9) and 25 other tissues See more Orthologs mouse all
PRKACB, Official Symbol PRKACBprovided by HGNC Official Full Name protein kinase cAMP-activated catalytic subunit betaprovided by HGNC Primary source HGNC:HGNC:9381 See related Ensembl:ENSG00000142875 MIM:176892; AllianceGenome:HGNC:9381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAFD2; PKACB; PKA C-beta Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014] Expression Broad expression in brain (RPKM 61.5), colon (RPKM 21.8) and 22 other tissues See more Orthologs mouse all
PRKACG, Official Symbol PRKACGprovided by HGNC Official Full Name protein kinase cAMP-activated catalytic subunit gammaprovided by HGNC Primary source HGNC:HGNC:9382 See related Ensembl:ENSG00000165059 MIM:176893; AllianceGenome:HGNC:9382 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAPG; PKACg; BDPLT19 Summary Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008] Orthologs all
PRKAG1, Official Symbol PRKAG1provided by HGNC Official Full Name protein kinase AMP-activated non-catalytic subunit gamma 1provided by HGNC Primary source HGNC:HGNC:9385 See related Ensembl:ENSG00000181929 MIM:602742; AllianceGenome:HGNC:9385 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMPKG Summary The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 18.1), adrenal (RPKM 16.8) and 25 other tissues See more Orthologs mouse all
PRKAG2, Official Symbol PRKAG2provided by HGNC Official Full Name protein kinase AMP-activated non-catalytic subunit gamma 2provided by HGNC Primary source HGNC:HGNC:9386 See related Ensembl:ENSG00000106617 MIM:602743; AllianceGenome:HGNC:9386 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAKG; CMH6; WPWS; AAKG2; H91620p Summary AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in heart (RPKM 15.2), prostate (RPKM 4.8) and 24 other tissues See more Orthologs mouse all
PRKAG3, Official Symbol PRKAG3provided by HGNC Official Full Name protein kinase AMP-activated non-catalytic subunit gamma 3provided by HGNC Primary source HGNC:HGNC:9387 See related Ensembl:ENSG00000115592 MIM:604976; AllianceGenome:HGNC:9387 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMPKG3; SMGMQTL Summary The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
PRKAR1A, Official Symbol PRKAR1Aprovided by HGNC Official Full Name protein kinase cAMP-dependent type I regulatory subunit alphaprovided by HGNC Primary source HGNC:HGNC:9388 See related Ensembl:ENSG00000108946 MIM:188830; AllianceGenome:HGNC:9388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1 Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in heart (RPKM 107.2), thyroid (RPKM 76.1) and 25 other tissues See more Orthologs mouse all
PRKAR1AP1, Official Symbol PRKAR1AP1provided by HGNC Official Full Name protein kinase cAMP-dependent type I regulatory subunit alpha pseudogene 1provided by HGNC Primary source HGNC:HGNC:9389 See related Ensembl:ENSG00000233401 AllianceGenome:HGNC:9389 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRKAR1AP
PRKAR1B, Official Symbol PRKAR1Bprovided by HGNC Official Full Name protein kinase cAMP-dependent type I regulatory subunit betaprovided by HGNC Primary source HGNC:HGNC:9390 See related Ensembl:ENSG00000188191 MIM:176911; AllianceGenome:HGNC:9390 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MASNS; PRKAR1 Summary The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015] Expression Biased expression in brain (RPKM 53.5), ovary (RPKM 6.9) and 11 other tissues See more Orthologs mouse all
PRKAR1B-AS1, Official Symbol PRKAR1B-AS1provided by HGNC Official Full Name PRKAR1B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40470 See related Ensembl:ENSG00000237181 AllianceGenome:HGNC:40470 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in lymph node (RPKM 1.7), spleen (RPKM 1.6) and 22 other tissues See more
PRKAR1B-AS2, Official Symbol PRKAR1B-AS2provided by HGNC Official Full Name PRKAR1B antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40469 See related Ensembl:ENSG00000229380 AllianceGenome:HGNC:40469 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in kidney (RPKM 1.5), pancreas (RPKM 0.5) and 4 other tissues See more
PRKAR2A, Official Symbol PRKAR2Aprovided by HGNC Official Full Name protein kinase cAMP-dependent type II regulatory subunit alphaprovided by HGNC Primary source HGNC:HGNC:9391 See related Ensembl:ENSG00000114302 MIM:176910; AllianceGenome:HGNC:9391 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKR2; PRKAR2 Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 11.3), colon (RPKM 10.8) and 25 other tissues See more Orthologs mouse all
PRKAR2A-AS1, Official Symbol PRKAR2A-AS1provided by HGNC Official Full Name PRKAR2A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40471 See related Ensembl:ENSG00000224424 AllianceGenome:HGNC:40471 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 1.9), brain (RPKM 0.5) and 18 other tissues See more
PRKAR2B, Official Symbol PRKAR2Bprovided by HGNC Official Full Name protein kinase cAMP-dependent type II regulatory subunit betaprovided by HGNC Primary source HGNC:HGNC:9392 See related Ensembl:ENSG00000005249 MIM:176912; AllianceGenome:HGNC:9392 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRKAR2; RII-BETA Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 215.5), adrenal (RPKM 38.6) and 7 other tissues See more Orthologs mouse all
PRKCA, Official Symbol PRKCAprovided by HGNC Official Full Name protein kinase C alphaprovided by HGNC Primary source HGNC:HGNC:9393 See related Ensembl:ENSG00000154229 MIM:176960; AllianceGenome:HGNC:9393 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 12.7), adrenal (RPKM 6.5) and 22 other tissues See more Orthologs mouse all
PRKCB, Official Symbol PRKCBprovided by HGNC Official Full Name protein kinase C betaprovided by HGNC Primary source HGNC:HGNC:9395 See related Ensembl:ENSG00000166501 MIM:176970; AllianceGenome:HGNC:9395 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKCB; PRKCB1; PRKCB2; PKCI(2); PKCbeta; PKC-beta Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 51.2), lymph node (RPKM 21.8) and 9 other tissues See more Orthologs mouse all
PRKCD, Official Symbol PRKCDprovided by HGNC Official Full Name protein kinase C deltaprovided by HGNC Primary source HGNC:HGNC:9399 See related Ensembl:ENSG00000163932 MIM:176977; AllianceGenome:HGNC:9399 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAY1; PKCD; ALPS3; CVID9; nPKC-delta Summary The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in adrenal (RPKM 23.1), bone marrow (RPKM 21.7) and 25 other tissues See more Orthologs mouse all
PRKCE, Official Symbol PRKCEprovided by HGNC Official Full Name protein kinase C epsilonprovided by HGNC Primary source HGNC:HGNC:9401 See related Ensembl:ENSG00000171132 MIM:176975; AllianceGenome:HGNC:9401 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKCE; nPKC-epsilon Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues See more Orthologs mouse all
PRKCG, Official Symbol PRKCGprovided by HGNC Official Full Name protein kinase C gammaprovided by HGNC Primary source HGNC:HGNC:9402 See related Ensembl:ENSG00000126583 MIM:176980; AllianceGenome:HGNC:9402 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKCC; PKCG; SCA14; PKCI(3); PKCgamma; PKC-gamma Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Biased expression in brain (RPKM 15.6) and testis (RPKM 1.4) See more Orthologs mouse all
PRKCH, Official Symbol PRKCHprovided by HGNC Official Full Name protein kinase C etaprovided by HGNC Primary source HGNC:HGNC:9403 See related Ensembl:ENSG00000027075 MIM:605437; AllianceGenome:HGNC:9403 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKCL; PKC-L; PRKCL; uORF2; nPKC-eta Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in lymph node (RPKM 18.8), spleen (RPKM 14.7) and 24 other tissues See more Orthologs mouse all
PRKCI, Official Symbol PRKCIprovided by HGNC Official Full Name protein kinase C iotaprovided by HGNC Primary source HGNC:HGNC:9404 See related Ensembl:ENSG00000163558 MIM:600539; AllianceGenome:HGNC:9404 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKCI; DXS1179E; nPKC-iota Summary This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in stomach (RPKM 19.1), thyroid (RPKM 17.9) and 24 other tissues See more Orthologs mouse all
PRKCIP1, Official Symbol PRKCIP1provided by HGNC Official Full Name PRKCI pseudogene 1provided by HGNC Primary source HGNC:HGNC:55035 See related AllianceGenome:HGNC:55035 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRKCQ, Official Symbol PRKCQprovided by HGNC Official Full Name protein kinase C thetaprovided by HGNC Primary source HGNC:HGNC:9410 See related Ensembl:ENSG00000065675 MIM:600448; AllianceGenome:HGNC:9410 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRKCT; nPKC-theta Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 4.0), lymph node (RPKM 2.9) and 17 other tissues See more Orthologs mouse all
PRKCQ-AS1, Official Symbol PRKCQ-AS1provided by HGNC Official Full Name PRKCQ antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44689 See related Ensembl:ENSG00000237943 AllianceGenome:HGNC:44689 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in lymph node (RPKM 5.5), appendix (RPKM 3.6) and 18 other tissues See more
PRKCSH, Official Symbol PRKCSHprovided by HGNC Official Full Name protein kinase C substrate 80K-Hprovided by HGNC Primary source HGNC:HGNC:9411 See related Ensembl:ENSG00000130175 MIM:177060; AllianceGenome:HGNC:9411 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GIIB; PCLD; PLD1; 80K-H; G19P1; PCLD1; PKCSH; AGE-R2; GIIbeta; VASAP-60; GluIIbeta Summary This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in ovary (RPKM 74.5), thyroid (RPKM 56.4) and 25 other tissues See more Orthologs mouse all
PRKCZ, Official Symbol PRKCZprovided by HGNC Official Full Name protein kinase C zetaprovided by HGNC Primary source HGNC:HGNC:9412 See related Ensembl:ENSG00000067606 MIM:176982; AllianceGenome:HGNC:9412 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKC2; PKC-ZETA Summary Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues See more Orthologs mouse all
PRKCZ-AS1, Official Symbol PRKCZ-AS1provided by HGNC Official Full Name PRKCZ antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40477 See related Ensembl:ENSG00000182873 AllianceGenome:HGNC:40477 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 2.5), small intestine (RPKM 2.2) and 23 other tissues See more Orthologs all
PRKD1, Official Symbol PRKD1provided by HGNC Official Full Name protein kinase D1provided by HGNC Primary source HGNC:HGNC:9407 See related Ensembl:ENSG00000184304 MIM:605435; AllianceGenome:HGNC:9407 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKD; PKCM; CHDED; PRKCM; PKC-MU Summary The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017] Expression Broad expression in testis (RPKM 3.2), prostate (RPKM 2.7) and 22 other tissues See more Orthologs mouse all
PRKD2, Official Symbol PRKD2provided by HGNC Official Full Name protein kinase D2provided by HGNC Primary source HGNC:HGNC:17293 See related Ensembl:ENSG00000105287 MIM:607074; AllianceGenome:HGNC:17293 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKD2; HSPC187; nPKC-D2 Summary The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Annotation information Note: PKD2 (GeneID: 5311) and PRKD2 (GeneID: 25865) share the PKD2 symbol/alias in common. PKD2 is a widely used alternative name for protein kinase D2 (PRKD2), which can be confused with the official symbol for PKD2/polycystin-2/polycystic kidney disease 2. [19 Jun 2018] Expression Ubiquitous expression in spleen (RPKM 19.7), lymph node (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
PRKD3, Official Symbol PRKD3provided by HGNC Official Full Name protein kinase D3provided by HGNC Primary source HGNC:HGNC:9408 See related Ensembl:ENSG00000115825 MIM:607077; AllianceGenome:HGNC:9408 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPK2; PKD3; PRKCN; PKC-NU; nPKC-NU Summary This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in lymph node (RPKM 16.0), testis (RPKM 14.3) and 25 other tissues See more Orthologs mouse all
PRKDC, Official Symbol PRKDCprovided by HGNC Official Full Name protein kinase, DNA-activated, catalytic subunitprovided by HGNC Primary source HGNC:HGNC:9413 See related Ensembl:ENSG00000253729 MIM:600899; AllianceGenome:HGNC:9413 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYRC; p350; DNAPK; DNPK1; HYRC1; IMD26; XRCC7; DNAPKc; DNA-PKC; DNA-PKcs Summary This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010] Expression Ubiquitous expression in testis (RPKM 10.8), lymph node (RPKM 10.6) and 25 other tissues See more Orthologs mouse all
PRKG1, Official Symbol PRKG1provided by HGNC Official Full Name protein kinase cGMP-dependent 1provided by HGNC Primary source HGNC:HGNC:9414 See related Ensembl:ENSG00000185532 MIM:176894; AllianceGenome:HGNC:9414 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKG; cGK; AAT8; PKG1; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha Summary Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in endometrium (RPKM 4.7), lung (RPKM 4.4) and 22 other tissues See more Orthologs mouse all
PRKG2, Official Symbol PRKG2provided by HGNC Official Full Name protein kinase cGMP-dependent 2provided by HGNC Primary source HGNC:HGNC:9416 See related Ensembl:ENSG00000138669 MIM:601591; AllianceGenome:HGNC:9416 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMD4; PKG2; SMDP; cGK2; cGKII; PRKGR2 Summary This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018] Expression Biased expression in prostate (RPKM 4.2), small intestine (RPKM 4.1) and 11 other tissues See more Orthologs mouse all
PRKG2-AS1, Official Symbol PRKG2-AS1provided by HGNC Official Full Name PRKG2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40478 See related Ensembl:ENSG00000251059 AllianceGenome:HGNC:40478 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.5) See more
PRKN, Official Symbol PRKNprovided by HGNC Official Full Name parkin RBR E3 ubiquitin protein ligaseprovided by HGNC Primary source HGNC:HGNC:8607 See related Ensembl:ENSG00000185345 MIM:602544; AllianceGenome:HGNC:8607 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDJ; AR-JP; LPRS2; PARK2 Summary The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008] Expression Broad expression in heart (RPKM 3.6), kidney (RPKM 3.5) and 21 other tissues See more Orthologs mouse all
PRKRA, Official Symbol PRKRAprovided by HGNC Official Full Name protein activator of interferon induced protein kinase EIF2AK2provided by HGNC Primary source HGNC:HGNC:9438 See related Ensembl:ENSG00000180228 MIM:603424; AllianceGenome:HGNC:9438 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAX; PACT; DYT16; HSD14 Summary This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in testis (RPKM 15.5), endometrium (RPKM 12.4) and 25 other tissues See more Orthologs mouse all
PRKRIP1, Official Symbol PRKRIP1provided by HGNC Official Full Name PRKR interacting protein 1provided by HGNC Primary source HGNC:HGNC:21894 See related Ensembl:ENSG00000128563 MIM:617458; AllianceGenome:HGNC:21894 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C114; KRBOX3 Summary Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 12.5), lymph node (RPKM 10.7) and 25 other tissues See more Orthologs mouse all