psui3905/ncbi_genes_summary huggingface dataset:
UGT2B17, Official Symbol UGT2B17provided by HGNC Official Full Name UDP glucuronosyltransferase family 2 member B17provided by HGNC Primary source HGNC:HGNC:12547 See related Ensembl:ENSG00000197888 MIM:601903; AllianceGenome:HGNC:12547 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BMND12; UDPGT2B17 Summary This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010] Expression Biased expression in small intestine (RPKM 270.0), colon (RPKM 223.4) and 4 other tissues See more Orthologs all
UGT2B26P, Official Symbol UGT2B26Pprovided by HGNC Official Full Name UDP glucuronosyltransferase family 2 member B26, pseudogeneprovided by HGNC Primary source HGNC:HGNC:12550 See related Ensembl:ENSG00000250919 AllianceGenome:HGNC:12550 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UGT2B28, Official Symbol UGT2B28provided by HGNC Official Full Name UDP glucuronosyltransferase family 2 member B28provided by HGNC Primary source HGNC:HGNC:13479 See related Ensembl:ENSG00000135226 MIM:606497; AllianceGenome:HGNC:13479 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011] Expression Biased expression in gall bladder (RPKM 10.0) and salivary gland (RPKM 0.9) See more
UGT2B4, Official Symbol UGT2B4provided by HGNC Official Full Name UDP glucuronosyltransferase family 2 member B4provided by HGNC Primary source HGNC:HGNC:12553 See related Ensembl:ENSG00000156096 MIM:600067; AllianceGenome:HGNC:12553 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLUG25; UDPGTH1; UGT2B11; UDPGT2B4; UDPGTh-1 Summary Enables glucuronosyltransferase activity. Involved in cellular glucuronidation and estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward liver (RPKM 259.3) See more Orthologs all
UGT2B7, Official Symbol UGT2B7provided by HGNC Official Full Name UDP glucuronosyltransferase family 2 member B7provided by HGNC Primary source HGNC:HGNC:12554 See related Ensembl:ENSG00000171234 MIM:600068; AllianceGenome:HGNC:12554 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UGT2B9; UDPGTH2; UDPGT2B7; UDPGTh-2; UDPGT 2B7; UDPGT 2B9 Summary The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017] Expression Biased expression in kidney (RPKM 335.9), liver (RPKM 240.7) and 2 other tissues See more Orthologs all
UGT3A1, Official Symbol UGT3A1provided by HGNC Official Full Name UDP glycosyltransferase family 3 member A1provided by HGNC Primary source HGNC:HGNC:26625 See related Ensembl:ENSG00000145626 MIM:616383; AllianceGenome:HGNC:26625 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables glucuronosyltransferase activity. Part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 14.9), liver (RPKM 11.3) and 3 other tissues See more Orthologs mouse all
UGT3A2, Official Symbol UGT3A2provided by HGNC Official Full Name UDP glycosyltransferase family 3 member A2provided by HGNC Primary source HGNC:HGNC:27266 See related Ensembl:ENSG00000168671 MIM:616384; AllianceGenome:HGNC:27266 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables UDP-glycosyltransferase activity. Acts upstream of or within cellular response to genistein. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 4.5), bone marrow (RPKM 1.8) and 5 other tissues See more Orthologs mouse all
UGT8, Official Symbol UGT8provided by HGNC Official Full Name UDP glycosyltransferase 8provided by HGNC Primary source HGNC:HGNC:12555 See related Ensembl:ENSG00000174607 MIM:601291; AllianceGenome:HGNC:12555 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGT; UGT4 Summary The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] Expression Biased expression in brain (RPKM 15.7), colon (RPKM 5.2) and 10 other tissues See more Orthologs mouse all
UHMK1, Official Symbol UHMK1provided by HGNC Official Full Name U2AF homology motif kinase 1provided by HGNC Primary source HGNC:HGNC:19683 See related Ensembl:ENSG00000152332 MIM:608849; AllianceGenome:HGNC:19683 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIS; KIST; P-CIP2 Summary The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Ubiquitous expression in kidney (RPKM 18.6), lymph node (RPKM 18.0) and 25 other tissues See more Orthologs mouse all
UHRF1, Official Symbol UHRF1provided by HGNC Official Full Name ubiquitin like with PHD and ring finger domains 1provided by HGNC Primary source HGNC:HGNC:12556 See related Ensembl:ENSG00000276043 MIM:607990; AllianceGenome:HGNC:12556 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95 Summary This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] Expression Broad expression in bone marrow (RPKM 7.7), lymph node (RPKM 6.3) and 14 other tissues See more Orthologs mouse all
UHRF2, Official Symbol UHRF2provided by HGNC Official Full Name ubiquitin like with PHD and ring finger domains 2provided by HGNC Primary source HGNC:HGNC:12557 See related Ensembl:ENSG00000147854 MIM:615211; AllianceGenome:HGNC:12557 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIRF; URF2; RNF107; TDRD23 Summary This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in bone marrow (RPKM 16.7), lymph node (RPKM 12.5) and 25 other tissues See more Orthologs mouse all
UICLM, Official Symbol UICLMprovided by HGNC Official Full Name up-regulated in colorectal cancer liver metastasisprovided by HGNC Primary source HGNC:HGNC:54869 See related Ensembl:ENSG00000233392 AllianceGenome:HGNC:54869 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CROCC2-AS1 Expression Biased expression in spleen (RPKM 4.9), lymph node (RPKM 1.7) and 2 other tissues See more
UIMC1, Official Symbol UIMC1provided by HGNC Official Full Name ubiquitin interaction motif containing 1provided by HGNC Primary source HGNC:HGNC:30298 See related Ensembl:ENSG00000087206 MIM:609433; AllianceGenome:HGNC:30298 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAP80; X2HRIP110 Summary This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Broad expression in testis (RPKM 26.7), bone marrow (RPKM 12.5) and 24 other tissues See more Orthologs mouse all
ULBP1, Official Symbol ULBP1provided by HGNC Official Full Name UL16 binding protein 1provided by HGNC Primary source HGNC:HGNC:14893 See related Ensembl:ENSG00000111981 MIM:605697; AllianceGenome:HGNC:14893 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2DL-1; RAET1I; NKG2DL1 Summary The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression Biased expression in testis (RPKM 1.6), lung (RPKM 0.5) and 3 other tissues See more Orthologs mouse all
ULBP2, Official Symbol ULBP2provided by HGNC Official Full Name UL16 binding protein 2provided by HGNC Primary source HGNC:HGNC:14894 See related Ensembl:ENSG00000131015 MIM:605698; AllianceGenome:HGNC:14894 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha Summary This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015] Expression Biased expression in esophagus (RPKM 5.0), lung (RPKM 1.3) and 11 other tissues See more Orthologs all
ULBP3, Official Symbol ULBP3provided by HGNC Official Full Name UL16 binding protein 3provided by HGNC Primary source HGNC:HGNC:14895 See related Ensembl:ENSG00000131019 MIM:605699; AllianceGenome:HGNC:14895 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2DL-3; RAET1N; NKG2DL3 Summary The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015] Expression Broad expression in testis (RPKM 3.9), thyroid (RPKM 2.5) and 17 other tissues See more Orthologs all
ULK1, Official Symbol ULK1provided by HGNC Official Full Name unc-51 like autophagy activating kinase 1provided by HGNC Primary source HGNC:HGNC:12558 See related Ensembl:ENSG00000177169 MIM:603168; AllianceGenome:HGNC:12558 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATG1; ATG1A; UNC51; hATG1; Unc51.1 Summary Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues See more Orthologs mouse all
ULK2, Official Symbol ULK2provided by HGNC Official Full Name unc-51 like autophagy activating kinase 2provided by HGNC Primary source HGNC:HGNC:13480 See related Ensembl:ENSG00000083290 MIM:608650; AllianceGenome:HGNC:13480 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATG1B; Unc51.2 Summary This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008] Expression Broad expression in testis (RPKM 16.5), brain (RPKM 7.4) and 21 other tissues See more Orthologs mouse all
ULK3, Official Symbol ULK3provided by HGNC Official Full Name unc-51 like kinase 3provided by HGNC Primary source HGNC:HGNC:19703 See related Ensembl:ENSG00000140474 MIM:613472; AllianceGenome:HGNC:19703 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables protein serine/threonine kinase activity. Involved in several processes, including fibroblast activation; protein autophosphorylation; and regulation of smoothened signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 31.2), small intestine (RPKM 22.9) and 25 other tissues See more Orthologs mouse all
ULK4, Official Symbol ULK4provided by HGNC Official Full Name unc-51 like kinase 4provided by HGNC Primary source HGNC:HGNC:15784 See related Ensembl:ENSG00000168038 MIM:617010; AllianceGenome:HGNC:15784 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM7C1; REC01035 Summary This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016] Expression Broad expression in testis (RPKM 5.0), thyroid (RPKM 0.8) and 16 other tissues See more Orthologs mouse all
ULK4P1, Official Symbol ULK4P1provided by HGNC Official Full Name ULK4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:15775 See related Ensembl:ENSG00000291023 AllianceGenome:HGNC:15775 Gene type pseudo RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D-X; FAM7A1 Expression Broad expression in testis (RPKM 7.6), fat (RPKM 3.5) and 17 other tissues See more
ULK4P2, Official Symbol ULK4P2provided by HGNC Official Full Name ULK4 pseudogene 2provided by HGNC Primary source HGNC:HGNC:15776 See related Ensembl:ENSG00000290723 AllianceGenome:HGNC:15776 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D-X; FAM7A2 Expression Broad expression in testis (RPKM 7.0), fat (RPKM 3.4) and 17 other tissues See more
ULK4P3, Official Symbol ULK4P3provided by HGNC Official Full Name ULK4 pseudogene 3provided by HGNC Primary source HGNC:HGNC:15777 See related Ensembl:ENSG00000290997 AllianceGenome:HGNC:15777 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D-X; FAM7A3 Expression Broad expression in testis (RPKM 5.6), fat (RPKM 2.2) and 14 other tissues See more
UMAD1, Official Symbol UMAD1provided by HGNC Official Full Name UBAP1-MVB12-associated (UMA) domain containing 1provided by HGNC Primary source HGNC:HGNC:48955 See related Ensembl:ENSG00000219545 AllianceGenome:HGNC:48955 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPA3OS; RPA3-AS1 Expression Ubiquitous expression in thyroid (RPKM 13.8), adrenal (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
UMLILO, Official Symbol UMLILOprovided by HGNC Official Full Name upstream master lncRNA of the inflammatory chemokine locusprovided by HGNC Primary source HGNC:HGNC:51824 See related AllianceGenome:HGNC:51824 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
UMOD, Official Symbol UMODprovided by HGNC Official Full Name uromodulinprovided by HGNC Primary source HGNC:HGNC:12559 See related Ensembl:ENSG00000169344 MIM:191845; AllianceGenome:HGNC:12559 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADTKD1; ADMCKD2 Summary The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Restricted expression toward kidney (RPKM 990.9) See more Orthologs mouse all
UMODL1, Official Symbol UMODL1provided by HGNC Official Full Name uromodulin like 1provided by HGNC Primary source HGNC:HGNC:12560 See related Ensembl:ENSG00000177398 MIM:613859; AllianceGenome:HGNC:12560 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be an extracellular matrix structural constituent. Predicted to be involved in neutrophil migration. Predicted to act upstream of or within several processes, including adipose tissue development; cellular response to gonadotropin-releasing hormone; and regulation of ovarian follicle development. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be integral component of membrane. Predicted to be active in apical plasma membrane; cell surface; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
UMODL1-AS1, Official Symbol UMODL1-AS1provided by HGNC Official Full Name UMODL1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:23821 See related Ensembl:ENSG00000184385 AllianceGenome:HGNC:23821 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C21orf128 Expression Low expression observed in reference dataset See more
UMPS, Official Symbol UMPSprovided by HGNC Official Full Name uridine monophosphate synthetaseprovided by HGNC Primary source HGNC:HGNC:12563 See related Ensembl:ENSG00000114491 MIM:613891; AllianceGenome:HGNC:12563 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPRT Summary This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in placenta (RPKM 3.1), esophagus (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
UNC119, Official Symbol UNC119provided by HGNC Official Full Name unc-119 lipid binding chaperoneprovided by HGNC Primary source HGNC:HGNC:12565 See related Ensembl:ENSG00000109103 MIM:604011; AllianceGenome:HGNC:12565 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRG4; POC7; IMD13; POC7A; CORD24 Summary This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 17.1), bone marrow (RPKM 16.7) and 25 other tissues See more Orthologs mouse all
UNC119B, Official Symbol UNC119Bprovided by HGNC Official Full Name unc-119 lipid binding chaperone Bprovided by HGNC Primary source HGNC:HGNC:16488 See related Ensembl:ENSG00000175970 AllianceGenome:HGNC:16488 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POC7B Summary Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 22.0), ovary (RPKM 19.5) and 24 other tissues See more Orthologs mouse all
UNC13A, Official Symbol UNC13Aprovided by HGNC Official Full Name unc-13 homolog Aprovided by HGNC Primary source HGNC:HGNC:23150 See related Ensembl:ENSG00000130477 MIM:609894; AllianceGenome:HGNC:23150 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Munc13-1 Summary This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012] Expression Biased expression in brain (RPKM 22.6), adrenal (RPKM 1.5) and 1 other tissue See more Orthologs mouse all
UNC13B, Official Symbol UNC13Bprovided by HGNC Official Full Name unc-13 homolog Bprovided by HGNC Primary source HGNC:HGNC:12566 See related Ensembl:ENSG00000198722 MIM:605836; AllianceGenome:HGNC:12566 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC13; MUNC13; Unc13h2; munc13-2 Summary This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 12.8), kidney (RPKM 6.6) and 23 other tissues See more Orthologs mouse all
UNC13C, Official Symbol UNC13Cprovided by HGNC Official Full Name unc-13 homolog Cprovided by HGNC Primary source HGNC:HGNC:23149 See related Ensembl:ENSG00000137766 MIM:614568; AllianceGenome:HGNC:23149 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Predicted to be involved in several processes, including glutamatergic synaptic transmission; regulated exocytosis; and synaptic vesicle maturation. Predicted to be located in presynaptic active zone. Predicted to be active in several cellular components, including axon terminus; parallel fiber to Purkinje cell synapse; and presynaptic active zone cytoplasmic component. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 3.2), thyroid (RPKM 0.4) and 4 other tissues See more Orthologs mouse all
UNC13D, Official Symbol UNC13Dprovided by HGNC Official Full Name unc-13 homolog Dprovided by HGNC Primary source HGNC:HGNC:23147 See related Ensembl:ENSG00000092929 MIM:608897; AllianceGenome:HGNC:23147 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHL3; HLH3; HPLH3; Munc13-4 Summary This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 20.9), lung (RPKM 16.7) and 21 other tissues See more Orthologs mouse all
UNC45A, Official Symbol UNC45Aprovided by HGNC Official Full Name unc-45 myosin chaperone Aprovided by HGNC Primary source HGNC:HGNC:30594 See related Ensembl:ENSG00000140553 MIM:611219; AllianceGenome:HGNC:30594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OOHE; SMAP1; SMAP-1; GCUNC45; UNC-45A; GC-UNC45; GCUNC-45; IRO039700 Summary This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018] Expression Ubiquitous expression in prostate (RPKM 14.4), skin (RPKM 14.0) and 25 other tissues See more Orthologs mouse all
UNC45B, Official Symbol UNC45Bprovided by HGNC Official Full Name unc-45 myosin chaperone Bprovided by HGNC Primary source HGNC:HGNC:14304 See related Ensembl:ENSG00000141161 MIM:611220; AllianceGenome:HGNC:14304 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMYA4; MFM11; UNC45; CTRCT43; SMUNC45; UNC-45B Summary This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Restricted expression toward heart (RPKM 36.4) See more Orthologs mouse all
UNC50, Official Symbol UNC50provided by HGNC Official Full Name unc-50 inner nuclear membrane RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:16046 See related Ensembl:ENSG00000115446 MIM:617826; AllianceGenome:HGNC:16046 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as URP; GMH1; UNCL; HSD23; PDLs22 Summary Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Predicted to be located in Golgi apparatus and nuclear inner membrane. Predicted to be integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 28.7), testis (RPKM 24.9) and 25 other tissues See more Orthologs mouse all
UNC5A, Official Symbol UNC5Aprovided by HGNC Official Full Name unc-5 netrin receptor Aprovided by HGNC Primary source HGNC:HGNC:12567 See related Ensembl:ENSG00000113763 MIM:607869; AllianceGenome:HGNC:12567 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC5H1 Summary UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004] Expression Biased expression in brain (RPKM 7.1) and adrenal (RPKM 2.6) See more Orthologs mouse all
UNC5B, Official Symbol UNC5Bprovided by HGNC Official Full Name unc-5 netrin receptor Bprovided by HGNC Primary source HGNC:HGNC:12568 See related Ensembl:ENSG00000107731 MIM:607870; AllianceGenome:HGNC:12568 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC5H2; p53RDL1 Summary This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in brain (RPKM 4.8), gall bladder (RPKM 4.7) and 24 other tissues See more Orthologs mouse all
UNC5B-AS1, Official Symbol UNC5B-AS1provided by HGNC Official Full Name UNC5B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:45096 See related Ensembl:ENSG00000237512 AllianceGenome:HGNC:45096 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UASR1; TP53LC05 Expression Biased expression in stomach (RPKM 9.7) and heart (RPKM 1.2) See more
UNC5C, Official Symbol UNC5Cprovided by HGNC Official Full Name unc-5 netrin receptor Cprovided by HGNC Primary source HGNC:HGNC:12569 See related Ensembl:ENSG00000182168 MIM:603610; AllianceGenome:HGNC:12569 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC5H3 Summary This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 2.7), adrenal (RPKM 2.7) and 21 other tissues See more Orthologs mouse all
UNC5C-AS1, Official Symbol UNC5C-AS1provided by HGNC Official Full Name UNC5C antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55246 See related AllianceGenome:HGNC:55246 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in thyroid (RPKM 2.8), brain (RPKM 2.7) and 19 other tissues See more
UNC5CL, Official Symbol UNC5CLprovided by HGNC Official Full Name unc-5 family C-terminal likeprovided by HGNC Primary source HGNC:HGNC:21203 See related Ensembl:ENSG00000124602 MIM:617464; AllianceGenome:HGNC:21203 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZUD; MUXA Summary Enables peptidase activity. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of JNK cascade. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 20.3), small intestine (RPKM 16.3) and 6 other tissues See more Orthologs mouse all
UNC5D, Official Symbol UNC5Dprovided by HGNC Official Full Name unc-5 netrin receptor Dprovided by HGNC Primary source HGNC:HGNC:18634 See related Ensembl:ENSG00000156687 MIM:616466; AllianceGenome:HGNC:18634 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Unc5h4; PRO34692 Summary Predicted to enable netrin receptor activity. Involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 2.7), duodenum (RPKM 2.4) and 8 other tissues See more Orthologs mouse all
UNC79, Official Symbol UNC79provided by HGNC Official Full Name unc-79 homolog, NALCN channel complex subunitprovided by HGNC Primary source HGNC:HGNC:19966 See related Ensembl:ENSG00000133958 MIM:616884; AllianceGenome:HGNC:19966 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA1409 Summary The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided by RefSeq, Sep 2016] Expression Biased expression in brain (RPKM 2.1), testis (RPKM 1.1) and 3 other tissues See more Orthologs mouse all
UNC80, Official Symbol UNC80provided by HGNC Official Full Name unc-80 homolog, NALCN channel complex subunitprovided by HGNC Primary source HGNC:HGNC:26582 See related Ensembl:ENSG00000144406 MIM:612636; AllianceGenome:HGNC:26582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNC-80; C2orf21 Summary The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016] Expression Biased expression in brain (RPKM 5.6), adrenal (RPKM 2.1) and 3 other tissues See more Orthologs mouse all
UNC93A, Official Symbol UNC93Aprovided by HGNC Official Full Name unc-93 homolog Aprovided by HGNC Primary source HGNC:HGNC:12570 See related Ensembl:ENSG00000112494 MIM:607995; AllianceGenome:HGNC:12570 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Unc-93A; dJ366N23.1; dJ366N23.2 Summary Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 2.6), duodenum (RPKM 2.2) and 5 other tissues See more Orthologs all
UNC93B1, Official Symbol UNC93B1provided by HGNC Official Full Name unc-93 homolog B1, TLR signaling regulatorprovided by HGNC Primary source HGNC:HGNC:13481 See related Ensembl:ENSG00000110057 MIM:608204; AllianceGenome:HGNC:13481 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IIAE1; UNC93; UNC93B; Unc-93B1 Summary This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014] Expression Broad expression in spleen (RPKM 27.3), lung (RPKM 14.0) and 24 other tissues See more Orthologs mouse all
UNC93B6, Official Symbol UNC93B6provided by HGNC Official Full Name unc-93 homolog B6 (pseudogene)provided by HGNC Primary source HGNC:HGNC:34053 See related Ensembl:ENSG00000255562 AllianceGenome:HGNC:34053 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UNC93B7, Official Symbol UNC93B7provided by HGNC Official Full Name unc-93 homolog B7 (pseudogene)provided by HGNC Primary source HGNC:HGNC:44036 See related AllianceGenome:HGNC:44036 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UNC93B8, Official Symbol UNC93B8provided by HGNC Official Full Name unc-93 homolog B8 (pseudogene)provided by HGNC Primary source HGNC:HGNC:44037 See related Ensembl:ENSG00000249272 AllianceGenome:HGNC:44037 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo