psui3905/ncbi_genes_summary huggingface dataset:
CCN5, Official Symbol CCN5provided by HGNC Official Full Name cellular communication network factor 5provided by HGNC Primary source HGNC:HGNC:12770 See related Ensembl:ENSG00000064205 MIM:603399; AllianceGenome:HGNC:12770 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT58; WISP2; CTGF-L Summary This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] Expression Biased expression in ovary (RPKM 59.2), fat (RPKM 22.7) and 9 other tissues See more Orthologs mouse all
CCN6, Official Symbol CCN6provided by HGNC Official Full Name cellular communication network factor 6provided by HGNC Primary source HGNC:HGNC:12771 See related Ensembl:ENSG00000112761 MIM:603400; AllianceGenome:HGNC:12771 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPD; LIBC; PPAC; PPRD; WISP3; WISP-3 Summary This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 1.0), skin (RPKM 0.5) and 4 other tissues See more Orthologs mouse all
CCNA1, Official Symbol CCNA1provided by HGNC Official Full Name cyclin A1provided by HGNC Primary source HGNC:HGNC:1577 See related Ensembl:ENSG00000133101 MIM:604036; AllianceGenome:HGNC:1577 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT146 Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 24.4) See more Orthologs mouse all
CCNA2, Official Symbol CCNA2provided by HGNC Official Full Name cyclin A2provided by HGNC Primary source HGNC:HGNC:1578 See related Ensembl:ENSG00000145386 MIM:123835; AllianceGenome:HGNC:1578 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCN1; CCNA Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016] Expression Broad expression in bone marrow (RPKM 15.5), lymph node (RPKM 14.7) and 20 other tissues See more Orthologs mouse all
CCNB1, Official Symbol CCNB1provided by HGNC Official Full Name cyclin B1provided by HGNC Primary source HGNC:HGNC:1579 See related Ensembl:ENSG00000134057 MIM:123836; AllianceGenome:HGNC:1579 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCNB Summary The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017] Expression Broad expression in lymph node (RPKM 19.4), testis (RPKM 14.8) and 21 other tissues See more Orthologs mouse all
CCNB1IP1, Official Symbol CCNB1IP1provided by HGNC Official Full Name cyclin B1 interacting protein 1provided by HGNC Primary source HGNC:HGNC:19437 See related Ensembl:ENSG00000100814 MIM:608249; AllianceGenome:HGNC:19437 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEI10; C14orf18 Summary HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in ovary (RPKM 41.4), thyroid (RPKM 28.8) and 24 other tissues See more Orthologs mouse all
CCNB1IP1P1, Official Symbol CCNB1IP1P1provided by HGNC Official Full Name cyclin B1 interacting protein 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:37693 See related AllianceGenome:HGNC:37693 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNB2, Official Symbol CCNB2provided by HGNC Official Full Name cyclin B2provided by HGNC Primary source HGNC:HGNC:1580 See related Ensembl:ENSG00000157456 MIM:602755; AllianceGenome:HGNC:1580 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HsT17299 Summary Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 42.1), bone marrow (RPKM 26.8) and 11 other tissues See more Orthologs mouse all
CCNB2P1, Official Symbol CCNB2P1provided by HGNC Official Full Name cyclin B2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50850 See related Ensembl:ENSG00000214998 AllianceGenome:HGNC:50850 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNB3, Official Symbol CCNB3provided by HGNC Official Full Name cyclin B3provided by HGNC Primary source HGNC:HGNC:18709 See related Ensembl:ENSG00000147082 MIM:300456; AllianceGenome:HGNC:18709 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYCB3 Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] Expression Biased expression in testis (RPKM 2.9), brain (RPKM 0.3) and 2 other tissues See more Orthologs mouse all
CCNB3P1, Official Symbol CCNB3P1provided by HGNC Official Full Name cyclin B3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50851 See related Ensembl:ENSG00000249616 AllianceGenome:HGNC:50851 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNC, Official Symbol CCNCprovided by HGNC Official Full Name cyclin Cprovided by HGNC Primary source HGNC:HGNC:1581 See related Ensembl:ENSG00000112237 MIM:123838; AllianceGenome:HGNC:1581 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CycC; SRB11; hSRB11 Summary The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 29.5), gall bladder (RPKM 20.6) and 25 other tissues See more Orthologs mouse all
CCND1, Official Symbol CCND1provided by HGNC Official Full Name cyclin D1provided by HGNC Primary source HGNC:HGNC:1582 See related Ensembl:ENSG00000110092 MIM:168461; AllianceGenome:HGNC:1582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCL1; PRAD1; U21B31; D11S287E Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019] Expression Ubiquitous expression in skin (RPKM 61.4), liver (RPKM 56.0) and 24 other tissues See more Orthologs mouse all
CCND2, Official Symbol CCND2provided by HGNC Official Full Name cyclin D2provided by HGNC Primary source HGNC:HGNC:1583 See related Ensembl:ENSG00000118971 MIM:123833; AllianceGenome:HGNC:1583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MPPH3; KIAK0002 Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014] Expression Ubiquitous expression in adrenal (RPKM 22.1), heart (RPKM 18.6) and 24 other tissues See more Orthologs mouse all
CCND2-AS1, Official Symbol CCND2-AS1provided by HGNC Official Full Name CCND2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49398 See related Ensembl:ENSG00000255920 AllianceGenome:HGNC:49398 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCND2-AS2 Expression Ubiquitous expression in adrenal (RPKM 4.8), brain (RPKM 4.4) and 25 other tissues See more
CCND3, Official Symbol CCND3provided by HGNC Official Full Name cyclin D3provided by HGNC Primary source HGNC:HGNC:1585 See related Ensembl:ENSG00000112576 MIM:123834; AllianceGenome:HGNC:1585 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] Expression Broad expression in bone marrow (RPKM 45.2), lymph node (RPKM 40.1) and 24 other tissues See more Orthologs mouse all
CCND3P1, Official Symbol CCND3P1provided by HGNC Official Full Name cyclin D3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:1586 See related Ensembl:ENSG00000224473 AllianceGenome:HGNC:1586 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCND3P
CCND3P2, Official Symbol CCND3P2provided by HGNC Official Full Name cyclin D3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:50852 See related Ensembl:ENSG00000265836 AllianceGenome:HGNC:50852 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNDBP1, Official Symbol CCNDBP1provided by HGNC Official Full Name cyclin D1 binding protein 1provided by HGNC Primary source HGNC:HGNC:1587 See related Ensembl:ENSG00000166946 MIM:607089; AllianceGenome:HGNC:1587 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HHM; DIP1; GCIP Summary This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009] Expression Ubiquitous expression in bone marrow (RPKM 23.1), placenta (RPKM 18.5) and 25 other tissues See more Orthologs mouse all
CCNE1, Official Symbol CCNE1provided by HGNC Official Full Name cyclin E1provided by HGNC Primary source HGNC:HGNC:1589 See related Ensembl:ENSG00000105173 MIM:123837; AllianceGenome:HGNC:1589 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCNE; pCCNE1 Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016] Expression Biased expression in placenta (RPKM 16.5), bone marrow (RPKM 11.3) and 12 other tissues See more Orthologs mouse all
CCNE2, Official Symbol CCNE2provided by HGNC Official Full Name cyclin E2provided by HGNC Primary source HGNC:HGNC:1590 See related Ensembl:ENSG00000175305 MIM:603775; AllianceGenome:HGNC:1590 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYCE2 Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 6.8), bone marrow (RPKM 6.2) and 20 other tissues See more Orthologs mouse all
CCNF, Official Symbol CCNFprovided by HGNC Official Full Name cyclin Fprovided by HGNC Primary source HGNC:HGNC:1591 See related Ensembl:ENSG00000162063 MIM:600227; AllianceGenome:HGNC:1591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBX1; FBXO1; FTDALS5 Summary This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 3.5), bone marrow (RPKM 2.7) and 24 other tissues See more Orthologs mouse all
CCNG1, Official Symbol CCNG1provided by HGNC Official Full Name cyclin G1provided by HGNC Primary source HGNC:HGNC:1592 See related Ensembl:ENSG00000113328 MIM:601578; AllianceGenome:HGNC:1592 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCNG Summary The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 74.2), small intestine (RPKM 61.6) and 25 other tissues See more Orthologs mouse all
CCNG1P1, Official Symbol CCNG1P1provided by HGNC Official Full Name cyclin G1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39177 See related Ensembl:ENSG00000218991 AllianceGenome:HGNC:39177 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNG2, Official Symbol CCNG2provided by HGNC Official Full Name cyclin G2provided by HGNC Primary source HGNC:HGNC:1593 See related Ensembl:ENSG00000138764 MIM:603203; AllianceGenome:HGNC:1593 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 25.3), prostate (RPKM 20.5) and 24 other tissues See more Orthologs mouse all
CCNG2P1, Official Symbol CCNG2P1provided by HGNC Official Full Name cyclin G2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50853 See related Ensembl:ENSG00000258112 AllianceGenome:HGNC:50853 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNH, Official Symbol CCNHprovided by HGNC Official Full Name cyclin Hprovided by HGNC Primary source HGNC:HGNC:1594 See related Ensembl:ENSG00000134480 MIM:601953; AllianceGenome:HGNC:1594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAK; p34; p37; CycH Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010] Expression Ubiquitous expression in placenta (RPKM 15.0), testis (RPKM 11.2) and 25 other tissues See more Orthologs mouse all
CCNI, Official Symbol CCNIprovided by HGNC Official Full Name cyclin Iprovided by HGNC Primary source HGNC:HGNC:1595 See related Ensembl:ENSG00000118816 MIM:618783; AllianceGenome:HGNC:1595 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYI; CYC1; CCNI1 Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in thyroid (RPKM 185.4), ovary (RPKM 178.6) and 25 other tissues See more Orthologs mouse all
CCNI2, Official Symbol CCNI2provided by HGNC Official Full Name cyclin I family member 2provided by HGNC Primary source HGNC:HGNC:33869 See related Ensembl:ENSG00000205089 MIM:620419; AllianceGenome:HGNC:33869 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 13.3), adrenal (RPKM 2.6) and 18 other tissues See more Orthologs all
CCNJ, Official Symbol CCNJprovided by HGNC Official Full Name cyclin Jprovided by HGNC Primary source HGNC:HGNC:23434 See related Ensembl:ENSG00000107443 MIM:620395; AllianceGenome:HGNC:23434 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bA690P14.1 Summary Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 3.4), testis (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
CCNJL, Official Symbol CCNJLprovided by HGNC Official Full Name cyclin J likeprovided by HGNC Primary source HGNC:HGNC:25876 See related Ensembl:ENSG00000135083 AllianceGenome:HGNC:25876 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 4.2), lung (RPKM 2.2) and 18 other tissues See more Orthologs mouse all
CCNK, Official Symbol CCNKprovided by HGNC Official Full Name cyclin Kprovided by HGNC Primary source HGNC:HGNC:1596 See related Ensembl:ENSG00000090061 MIM:603544; AllianceGenome:HGNC:1596 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPR4; IDDHDF Summary The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 33.7), testis (RPKM 31.2) and 25 other tissues See more Orthologs mouse all
CCNL1, Official Symbol CCNL1provided by HGNC Official Full Name cyclin L1provided by HGNC Primary source HGNC:HGNC:20569 See related Ensembl:ENSG00000163660 MIM:613384; AllianceGenome:HGNC:20569 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANIA6A; BM-001; PRO1073; ania-6a Summary Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 197.4), appendix (RPKM 28.6) and 17 other tissues See more Orthologs mouse all
CCNL2, Official Symbol CCNL2provided by HGNC Official Full Name cyclin L2provided by HGNC Primary source HGNC:HGNC:20570 See related Ensembl:ENSG00000221978 MIM:613482; AllianceGenome:HGNC:20570 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO Summary The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in skin (RPKM 45.3), endometrium (RPKM 44.2) and 25 other tissues See more Orthologs mouse all
CCNO, Official Symbol CCNOprovided by HGNC Official Full Name cyclin Oprovided by HGNC Primary source HGNC:HGNC:18576 See related Ensembl:ENSG00000152669 MIM:607752; AllianceGenome:HGNC:18576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCNU; UDG2; CILD29 Summary This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014] Annotation information Note: Due to a common symbol (UNG2) for the specific nuclear isoform of the UNG gene (GeneID 7374) and as a previous symbol for the CCNO gene (GeneID 10309), incorrect attributions of uracil DNA glycosylase activity have been made for CCNO in the scientific literature. CCNO was correctly identified as a cyclin protein family member in PubMed ID: 8419333. HIV-1 interacts with the UNG gene and not with the CCNO gene. [13 Feb 2013] Expression Broad expression in testis (RPKM 3.3), stomach (RPKM 2.3) and 16 other tissues See more Orthologs mouse all
CCNP, Official Symbol CCNPprovided by HGNC Official Full Name cyclin Pprovided by HGNC Primary source HGNC:HGNC:25805 See related Ensembl:ENSG00000105219 MIM:620396; AllianceGenome:HGNC:25805 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNTD2 Summary Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
CCNQ, Official Symbol CCNQprovided by HGNC Official Full Name cyclin Qprovided by HGNC Primary source HGNC:HGNC:28434 See related Ensembl:ENSG00000262919 MIM:300708; AllianceGenome:HGNC:28434 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CycM; FAM58A Summary Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in spleen (RPKM 3.6), placenta (RPKM 3.2) and 25 other tissues See more Orthologs mouse all
CCNT1, Official Symbol CCNT1provided by HGNC Official Full Name cyclin T1provided by HGNC Primary source HGNC:HGNC:1599 See related Ensembl:ENSG00000129315 MIM:143055; AllianceGenome:HGNC:1599 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCNT; CYCT1; HIVE1 Summary This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] Expression Ubiquitous expression in bone marrow (RPKM 11.5), testis (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
CCNT2, Official Symbol CCNT2provided by HGNC Official Full Name cyclin T2provided by HGNC Primary source HGNC:HGNC:1600 See related Ensembl:ENSG00000082258 MIM:603862; AllianceGenome:HGNC:1600 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYCT2 Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] Expression Ubiquitous expression in bone marrow (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
CCNT2-AS1, Official Symbol CCNT2-AS1provided by HGNC Official Full Name CCNT2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40130 See related AllianceGenome:HGNC:40130 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in kidney (RPKM 4.2), ovary (RPKM 3.1) and 24 other tissues See more
CCNT2P1, Official Symbol CCNT2P1provided by HGNC Official Full Name cyclin T2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39178 See related AllianceGenome:HGNC:39178 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNY, Official Symbol CCNYprovided by HGNC Official Full Name cyclin Yprovided by HGNC Primary source HGNC:HGNC:23354 See related Ensembl:ENSG00000108100 MIM:612786; AllianceGenome:HGNC:23354 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCNX; CFP1; CBCP1; C10orf9 Summary Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009] Expression Ubiquitous expression in testis (RPKM 35.4), brain (RPKM 17.2) and 25 other tissues See more Orthologs mouse all
CCNYL1, Official Symbol CCNYL1provided by HGNC Official Full Name cyclin Y like 1provided by HGNC Primary source HGNC:HGNC:26868 See related Ensembl:ENSG00000163249 AllianceGenome:HGNC:26868 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within flagellated sperm motility; regulation of protein kinase activity; and spermatogenesis. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 8.2), testis (RPKM 7.9) and 25 other tissues See more Orthologs mouse all
CCNYL4, Official Symbol CCNYL4provided by HGNC Official Full Name cyclin Y like 4 (pseudogene)provided by HGNC Primary source HGNC:HGNC:54655 See related AllianceGenome:HGNC:54655 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
CCNYL6, Official Symbol CCNYL6provided by HGNC Official Full Name cyclin Y like 6 (pseudogene)provided by HGNC Primary source HGNC:HGNC:54657 See related Ensembl:ENSG00000269845 AllianceGenome:HGNC:54657 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCNYL7, Official Symbol CCNYL7provided by HGNC Official Full Name cyclin Y like 7 (pseudogene)provided by HGNC Primary source HGNC:HGNC:54659 See related Ensembl:ENSG00000261528 AllianceGenome:HGNC:54659 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CCP110, Official Symbol CCP110provided by HGNC Official Full Name centriolar coiled-coil protein 110provided by HGNC Primary source HGNC:HGNC:24342 See related Ensembl:ENSG00000103540 MIM:609544; AllianceGenome:HGNC:24342 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP110; Cep110 Summary Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 21.6), brain (RPKM 10.5) and 22 other tissues See more Orthologs mouse all
CCPG1, Official Symbol CCPG1provided by HGNC Official Full Name cell cycle progression 1provided by HGNC Primary source HGNC:HGNC:24227 See related Ensembl:ENSG00000260916 MIM:611326; AllianceGenome:HGNC:24227 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPR8 Summary Involved in positive regulation of cell cycle and positive regulation of cell population proliferation. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 34.7), gall bladder (RPKM 22.2) and 25 other tissues See more Orthologs mouse all