psui3905/ncbi_genes_summary huggingface dataset:
INMT-MINDY4, Official Symbol INMT-MINDY4provided by HGNC Official Full Name INMT-MINDY4 readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:41995 See related Ensembl:ENSG00000254959 AllianceGenome:HGNC:41995 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INMT-FAM188B Summary This locus represents rare but naturally occurring read-through transcription between the INMT (indolethylamine N-methyltransferase) and FAM188B (family with sequence similarity 188, member B) genes on chromosome 7. The read-through transcript is unlikely to produce a protein because it is a nonsense-mediated mRNA decay (NMD) candidate based on translation from the supported INMT start codon. [provided by RefSeq, Nov 2010] Expression Broad expression in lung (RPKM 13.3), testis (RPKM 8.4) and 24 other tissues See more
INO80, Official Symbol INO80provided by HGNC Official Full Name INO80 complex ATPase subunitprovided by HGNC Primary source HGNC:HGNC:26956 See related Ensembl:ENSG00000128908 MIM:610169; AllianceGenome:HGNC:26956 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INOC1; INO80A Summary This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in bone marrow (RPKM 5.6), testis (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
INO80B, Official Symbol INO80Bprovided by HGNC Official Full Name INO80 complex subunit Bprovided by HGNC Primary source HGNC:HGNC:13324 See related Ensembl:ENSG00000115274 MIM:616456; AllianceGenome:HGNC:13324 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IES2; PAPA1; hIes2; PAPA-1; ZNHIT4; HMGA1L4; HMGIYL4; PAP-1BP Summary This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in prostate (RPKM 11.1), testis (RPKM 10.6) and 25 other tissues See more Orthologs mouse all
INO80B-WBP1, Official Symbol INO80B-WBP1provided by HGNC Official Full Name INO80B-WBP1 readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:49199 See related Ensembl:ENSG00000274049 AllianceGenome:HGNC:49199 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This locus represents naturally occurring read-through transcription between the neighboring INO80B (INO80 complex subunit B) and WBP1 (WW domain-binding protein 1) genes on chromosome 2. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in thyroid (RPKM 31.5), prostate (RPKM 31.0) and 25 other tissues See more
INO80C, Official Symbol INO80Cprovided by HGNC Official Full Name INO80 complex subunit Cprovided by HGNC Primary source HGNC:HGNC:26994 See related Ensembl:ENSG00000153391 AllianceGenome:HGNC:26994 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IES6; hIes6; C18orf37 Summary Predicted to be involved in chromatin remodeling. Part of Ino80 complex and MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 20.7), esophagus (RPKM 7.5) and 24 other tissues See more Orthologs mouse all
INO80D, Official Symbol INO80Dprovided by HGNC Official Full Name INO80 complex subunit Dprovided by HGNC Primary source HGNC:HGNC:25997 See related Ensembl:ENSG00000114933 MIM:619207; AllianceGenome:HGNC:25997 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in DNA recombination and DNA repair. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 2.7), thyroid (RPKM 1.0) and 25 other tissues See more Orthologs mouse all
INO80E, Official Symbol INO80Eprovided by HGNC Official Full Name INO80 complex subunit Eprovided by HGNC Primary source HGNC:HGNC:26905 See related Ensembl:ENSG00000169592 AllianceGenome:HGNC:26905 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCDC95 Summary Predicted to be involved in DNA recombination; DNA repair; and chromatin remodeling. Located in nucleolus and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 18.0), spleen (RPKM 15.7) and 25 other tissues See more Orthologs mouse all
INPP1, Official Symbol INPP1provided by HGNC Official Full Name inositol polyphosphate-1-phosphataseprovided by HGNC Primary source HGNC:HGNC:6071 See related Ensembl:ENSG00000151689 MIM:147263; AllianceGenome:HGNC:6071 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 21.9), esophagus (RPKM 18.0) and 24 other tissues See more Orthologs mouse all
INPP4A, Official Symbol INPP4Aprovided by HGNC Official Full Name inositol polyphosphate-4-phosphatase type I Aprovided by HGNC Primary source HGNC:HGNC:6074 See related Ensembl:ENSG00000040933 MIM:600916; AllianceGenome:HGNC:6074 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INPP4; TVAS1 Summary This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in brain (RPKM 6.3), spleen (RPKM 4.2) and 24 other tissues See more Orthologs mouse all
INPP4B, Official Symbol INPP4Bprovided by HGNC Official Full Name inositol polyphosphate-4-phosphatase type II Bprovided by HGNC Primary source HGNC:HGNC:6075 See related Ensembl:ENSG00000109452 MIM:607494; AllianceGenome:HGNC:6075 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 24 other tissues See more Orthologs mouse all
INPP5A, Official Symbol INPP5Aprovided by HGNC Official Full Name inositol polyphosphate-5-phosphatase Aprovided by HGNC Primary source HGNC:HGNC:6076 See related Ensembl:ENSG00000068383 MIM:600106; AllianceGenome:HGNC:6076 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 5PTASE Summary The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 7.6), testis (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
INPP5B, Official Symbol INPP5Bprovided by HGNC Official Full Name inositol polyphosphate-5-phosphatase Bprovided by HGNC Primary source HGNC:HGNC:6077 See related Ensembl:ENSG00000204084 MIM:147264; AllianceGenome:HGNC:6077 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 5PTase Summary This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in lymph node (RPKM 6.6), ovary (RPKM 6.5) and 25 other tissues See more Orthologs mouse all
INPP5D, Official Symbol INPP5Dprovided by HGNC Official Full Name inositol polyphosphate-5-phosphatase Dprovided by HGNC Primary source HGNC:HGNC:6079 See related Ensembl:ENSG00000168918 MIM:601582; AllianceGenome:HGNC:6079 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship Summary This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020] Expression Broad expression in lymph node (RPKM 33.2), spleen (RPKM 31.1) and 21 other tissues See more Orthologs mouse all
INPP5E, Official Symbol INPP5Eprovided by HGNC Official Full Name inositol polyphosphate-5-phosphatase Eprovided by HGNC Primary source HGNC:HGNC:21474 See related Ensembl:ENSG00000148384 MIM:613037; AllianceGenome:HGNC:21474 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin Summary The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in testis (RPKM 7.5), spleen (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
INPP5F, Official Symbol INPP5Fprovided by HGNC Official Full Name inositol polyphosphate-5-phosphatase Fprovided by HGNC Primary source HGNC:HGNC:17054 See related Ensembl:ENSG00000198825 MIM:609389; AllianceGenome:HGNC:17054 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAC2; hSAC2; MSTP007; MSTPO47 Summary The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] Expression Broad expression in brain (RPKM 17.8), testis (RPKM 4.5) and 22 other tissues See more Orthologs mouse all
INPP5J, Official Symbol INPP5Jprovided by HGNC Official Full Name inositol polyphosphate-5-phosphatase Jprovided by HGNC Primary source HGNC:HGNC:8956 See related Ensembl:ENSG00000185133 MIM:606481; AllianceGenome:HGNC:8956 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIPP; INPP5; PIB5PA Summary Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 63.8), small intestine (RPKM 7.6) and 4 other tissues See more Orthologs mouse all
INPP5K, Official Symbol INPP5Kprovided by HGNC Official Full Name inositol polyphosphate-5-phosphatase Kprovided by HGNC Primary source HGNC:HGNC:33882 See related Ensembl:ENSG00000132376 MIM:607875; AllianceGenome:HGNC:33882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPS; SKIP; MDCCAID Summary This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in fat (RPKM 17.9), lung (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
INPPL1, Official Symbol INPPL1provided by HGNC Official Full Name inositol polyphosphate phosphatase like 1provided by HGNC Primary source HGNC:HGNC:6080 See related Ensembl:ENSG00000165458 MIM:600829; AllianceGenome:HGNC:6080 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPSMD; SHIP2 Summary The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009] Expression Ubiquitous expression in placenta (RPKM 19.8), thyroid (RPKM 19.6) and 25 other tissues See more Orthologs mouse all
INS, Official Symbol INSprovided by HGNC Official Full Name insulinprovided by HGNC Primary source HGNC:HGNC:6081 See related Ensembl:ENSG00000254647 MIM:176730; AllianceGenome:HGNC:6081 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IDDM; ILPR; IRDN; IDDM1; IDDM2; PNDM4; MODY10 Summary This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020] Expression Restricted expression toward pancreas (RPKM 671.7) See more Orthologs mouse all
INS-IGF2, Official Symbol INS-IGF2provided by HGNC Official Full Name INS-IGF2 readthroughprovided by HGNC Primary source HGNC:HGNC:33527 See related Ensembl:ENSG00000129965 AllianceGenome:HGNC:33527 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INSIGF Summary This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 1227.5) and liver (RPKM 104.8) See more Orthologs all
INSC, Official Symbol INSCprovided by HGNC Official Full Name INSC spindle orientation adaptor proteinprovided by HGNC Primary source HGNC:HGNC:33116 See related Ensembl:ENSG00000188487 MIM:610668; AllianceGenome:HGNC:33116 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
INSIG1, Official Symbol INSIG1provided by HGNC Official Full Name insulin induced gene 1provided by HGNC Primary source HGNC:HGNC:6083 See related Ensembl:ENSG00000186480 MIM:602055; AllianceGenome:HGNC:6083 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL6 Summary This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] Expression Ubiquitous expression in liver (RPKM 104.0), fat (RPKM 35.8) and 24 other tissues See more Orthologs mouse all
INSIG1-DT, Official Symbol INSIG1-DTprovided by HGNC Official Full Name INSIG1 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55155 See related AllianceGenome:HGNC:55155 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in brain (RPKM 1.9), testis (RPKM 1.8) and 25 other tissues See more
INSIG2, Official Symbol INSIG2provided by HGNC Official Full Name insulin induced gene 2provided by HGNC Primary source HGNC:HGNC:20452 See related Ensembl:ENSG00000125629 MIM:608660; AllianceGenome:HGNC:20452 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INSIG-2 Summary The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 12.3), lung (RPKM 10.5) and 25 other tissues See more Orthologs mouse all
INSL3, Official Symbol INSL3provided by HGNC Official Full Name insulin like 3provided by HGNC Primary source HGNC:HGNC:6086 See related Ensembl:ENSG00000248099 MIM:146738; AllianceGenome:HGNC:6086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RLF; RLNL; ley-I-L Summary This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012] Expression Restricted expression toward testis (RPKM 240.7) See more Orthologs mouse all
INSL4, Official Symbol INSL4provided by HGNC Official Full Name insulin like 4provided by HGNC Primary source HGNC:HGNC:6087 See related Ensembl:ENSG00000120211 MIM:600910; AllianceGenome:HGNC:6087 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPIL; PLACENTIN Summary INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008] Expression Restricted expression toward placenta (RPKM 30.0) See more Orthologs all
INSL5, Official Symbol INSL5provided by HGNC Official Full Name insulin like 5provided by HGNC Primary source HGNC:HGNC:6088 See related Ensembl:ENSG00000172410 MIM:606413; AllianceGenome:HGNC:6088 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRO182; UNQ156 Summary The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008] Expression Restricted expression toward colon (RPKM 81.8) See more Orthologs mouse all
INSL6, Official Symbol INSL6provided by HGNC Official Full Name insulin like 6provided by HGNC Primary source HGNC:HGNC:6089 See related Ensembl:ENSG00000120210 MIM:606414; AllianceGenome:HGNC:6089 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIF1 Summary The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 6.0) See more Orthologs mouse all
INSM1, Official Symbol INSM1provided by HGNC Official Full Name INSM transcriptional repressor 1provided by HGNC Primary source HGNC:HGNC:6090 See related Ensembl:ENSG00000173404 MIM:600010; AllianceGenome:HGNC:6090 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IA1; IA-1 Summary Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008] Orthologs mouse all
INSM2, Official Symbol INSM2provided by HGNC Official Full Name INSM transcriptional repressor 2provided by HGNC Primary source HGNC:HGNC:17539 See related Ensembl:ENSG00000168348 MIM:614027; AllianceGenome:HGNC:17539 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IA6; IA-6; mlt1 Summary Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
INSR, Official Symbol INSRprovided by HGNC Official Full Name insulin receptorprovided by HGNC Primary source HGNC:HGNC:6091 See related Ensembl:ENSG00000171105 MIM:147670; AllianceGenome:HGNC:6091 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HHF5; CD220 Summary This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in kidney (RPKM 16.5), spleen (RPKM 15.9) and 25 other tissues See more Orthologs mouse all
INSRR, Official Symbol INSRRprovided by HGNC Official Full Name insulin receptor related receptorprovided by HGNC Primary source HGNC:HGNC:6093 See related Ensembl:ENSG00000027644 MIM:147671; AllianceGenome:HGNC:6093 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRR Summary Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 1.2), testis (RPKM 1.1) and 5 other tissues See more Orthologs mouse all
INSYN1, Official Symbol INSYN1provided by HGNC Official Full Name inhibitory synaptic factor 1provided by HGNC Primary source HGNC:HGNC:33753 See related Ensembl:ENSG00000205363 MIM:617128; AllianceGenome:HGNC:33753 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C15orf59 Summary Predicted to be involved in inhibitory postsynaptic potential. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 6.6), heart (RPKM 2.3) and 12 other tissues See more Orthologs mouse all
INSYN1-AS1, Official Symbol INSYN1-AS1provided by HGNC Official Full Name INSYN1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51422 See related AllianceGenome:HGNC:51422 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C15orf59-AS1 Expression Biased expression in testis (RPKM 3.2), brain (RPKM 0.7) and 1 other tissue See more
INSYN2A, Official Symbol INSYN2Aprovided by HGNC Official Full Name inhibitory synaptic factor 2Aprovided by HGNC Primary source HGNC:HGNC:33859 See related Ensembl:ENSG00000188916 MIM:617129; AllianceGenome:HGNC:33859 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INSYN2; FAM196A; C10orf141 Summary Predicted to be involved in inhibitory postsynaptic potential. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
INSYN2B, Official Symbol INSYN2Bprovided by HGNC Official Full Name inhibitory synaptic factor family member 2Bprovided by HGNC Primary source HGNC:HGNC:37271 See related Ensembl:ENSG00000204767 AllianceGenome:HGNC:37271 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C5orf57; FAM196B Expression Biased expression in brain (RPKM 3.1), salivary gland (RPKM 1.3) and 8 other tissues See more Orthologs mouse all
INTS1, Official Symbol INTS1provided by HGNC Official Full Name integrator complex subunit 1provided by HGNC Primary source HGNC:HGNC:24555 See related Ensembl:ENSG00000164880 MIM:611345; AllianceGenome:HGNC:24555 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT1; NET28; NDCAGF Summary INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 20.1), kidney (RPKM 10.8) and 25 other tissues See more Orthologs mouse all
INTS10, Official Symbol INTS10provided by HGNC Official Full Name integrator complex subunit 10provided by HGNC Primary source HGNC:HGNC:25548 See related Ensembl:ENSG00000104613 MIM:611353; AllianceGenome:HGNC:25548 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT10; C8orf35 Summary INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
INTS11, Official Symbol INTS11provided by HGNC Official Full Name integrator complex subunit 11provided by HGNC Primary source HGNC:HGNC:26052 See related Ensembl:ENSG00000127054 MIM:611354; AllianceGenome:HGNC:26052 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RC68; INT11; PSF3L; RC-68; CPSF3L; CPSF73L; NEDMLOB Summary The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 35.0), endometrium (RPKM 21.3) and 25 other tissues See more Orthologs mouse all
INTS12, Official Symbol INTS12provided by HGNC Official Full Name integrator complex subunit 12provided by HGNC Primary source HGNC:HGNC:25067 See related Ensembl:ENSG00000138785 MIM:611355; AllianceGenome:HGNC:25067 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT12; PHF22; SBBI22 Summary INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in thyroid (RPKM 6.3), bone marrow (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
INTS13, Official Symbol INTS13provided by HGNC Official Full Name integrator complex subunit 13provided by HGNC Primary source HGNC:HGNC:20174 See related Ensembl:ENSG00000064102 MIM:615079; AllianceGenome:HGNC:20174 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASUN; GCT1; NET48; Mat89Bb; SPATA30; C12orf11 Summary Involved in regulation of mitotic cell cycle. Acts upstream of or within centrosome localization; mitotic spindle organization; and protein localization to nuclear envelope. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 8.5), lymph node (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
INTS14, Official Symbol INTS14provided by HGNC Official Full Name integrator complex subunit 14provided by HGNC Primary source HGNC:HGNC:25372 See related Ensembl:ENSG00000138614 AllianceGenome:HGNC:25372 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWA9; C15orf44 Summary Predicted to be involved in snRNA 3'-end processing. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 12.8), testis (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
INTS3, Official Symbol INTS3provided by HGNC Official Full Name integrator complex subunit 3provided by HGNC Primary source HGNC:HGNC:26153 See related Ensembl:ENSG00000143624 MIM:611347; AllianceGenome:HGNC:26153 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT3; SOSSA; SOSS-A; C1orf60; C1orf193 Summary The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016] Expression Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues See more Orthologs mouse all
INTS4, Official Symbol INTS4provided by HGNC Official Full Name integrator complex subunit 4provided by HGNC Primary source HGNC:HGNC:25048 See related Ensembl:ENSG00000149262 MIM:611348; AllianceGenome:HGNC:25048 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT4; MST093 Summary INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in lymph node (RPKM 4.0), appendix (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
INTS4P2, Official Symbol INTS4P2provided by HGNC Official Full Name integrator complex subunit 4 pseudogene 2provided by HGNC Primary source HGNC:HGNC:22351 See related Ensembl:ENSG00000273024 AllianceGenome:HGNC:22351 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INTS4L2 Expression Ubiquitous expression in testis (RPKM 3.6), appendix (RPKM 3.0) and 25 other tissues See more
INTS5, Official Symbol INTS5provided by HGNC Official Full Name integrator complex subunit 5provided by HGNC Primary source HGNC:HGNC:29352 See related Ensembl:ENSG00000185085 MIM:611349; AllianceGenome:HGNC:29352 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT5; KIAA1698 Summary The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016] Expression Ubiquitous expression in ovary (RPKM 6.3), thyroid (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
INTS6, Official Symbol INTS6provided by HGNC Official Full Name integrator complex subunit 6provided by HGNC Primary source HGNC:HGNC:14879 See related Ensembl:ENSG00000102786 MIM:604331; AllianceGenome:HGNC:14879 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HDB; INT6; DBI-1; DDX26; DICE1; DDX26A; Notchl2 Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015] Expression Broad expression in testis (RPKM 13.0), thyroid (RPKM 3.7) and 25 other tissues See more Orthologs mouse all
INTS6-AS1, Official Symbol INTS6-AS1provided by HGNC Official Full Name INTS6 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:42691 See related Ensembl:ENSG00000236778 AllianceGenome:HGNC:42691 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 4.1), lymph node (RPKM 2.5) and 25 other tissues See more
INTS6L, Official Symbol INTS6Lprovided by HGNC Official Full Name integrator complex subunit 6 likeprovided by HGNC Primary source HGNC:HGNC:27334 See related Ensembl:ENSG00000165359 AllianceGenome:HGNC:27334 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX26B Summary Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 6.8), bone marrow (RPKM 4.6) and 23 other tissues See more Orthologs mouse all
INTS6L-AS1, Official Symbol INTS6L-AS1provided by HGNC Official Full Name INTS6L antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41180 See related Ensembl:ENSG00000225235 AllianceGenome:HGNC:41180 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX26B-AS1 Expression Low expression observed in reference dataset See more
INTS6P1, Official Symbol INTS6P1provided by HGNC Official Full Name integrator complex subunit 6 pseudogene 1provided by HGNC Primary source HGNC:HGNC:43921 See related Ensembl:ENSG00000250492 AllianceGenome:HGNC:43921 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
INTS7, Official Symbol INTS7provided by HGNC Official Full Name integrator complex subunit 7provided by HGNC Primary source HGNC:HGNC:24484 See related Ensembl:ENSG00000143493 MIM:611350; AllianceGenome:HGNC:24484 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT7; C1orf73 Summary This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Broad expression in testis (RPKM 9.9), lymph node (RPKM 3.5) and 24 other tissues See more Orthologs mouse all