psui3905/ncbi_genes_summary huggingface dataset:
CD38, Official Symbol CD38provided by HGNC Official Full Name CD38 moleculeprovided by HGNC Primary source HGNC:HGNC:1667 See related Ensembl:ENSG00000004468 MIM:107270; AllianceGenome:HGNC:1667 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADPRC1; cADPR1; ADPRC 1 Summary The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Broad expression in lymph node (RPKM 11.2), brain (RPKM 10.3) and 17 other tissues See more Orthologs mouse all
CD3D, Official Symbol CD3Dprovided by HGNC Official Full Name CD3 delta subunit of T-cell receptor complexprovided by HGNC Primary source HGNC:HGNC:1673 See related Ensembl:ENSG00000167286 MIM:186790; AllianceGenome:HGNC:1673 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T3D; IMD19; CD3DELTA; CD3-DELTA Summary The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009] Expression Biased expression in lymph node (RPKM 30.2), appendix (RPKM 14.7) and 9 other tissues See more Orthologs mouse all
CD3E, Official Symbol CD3Eprovided by HGNC Official Full Name CD3 epsilon subunit of T-cell receptor complexprovided by HGNC Primary source HGNC:HGNC:1674 See related Ensembl:ENSG00000198851 MIM:186830; AllianceGenome:HGNC:1674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T3E; TCRE; IMD18; CD3epsilon Summary The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 92.6), appendix (RPKM 45.9) and 9 other tissues See more Orthologs mouse all
CD3G, Official Symbol CD3Gprovided by HGNC Official Full Name CD3 gamma subunit of T-cell receptor complexprovided by HGNC Primary source HGNC:HGNC:1675 See related Ensembl:ENSG00000160654 MIM:186740; AllianceGenome:HGNC:1675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T3G; IMD17; CD3GAMMA; CD3-GAMMA Summary The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues See more Orthologs mouse all
CD4, Official Symbol CD4provided by HGNC Official Full Name CD4 moleculeprovided by HGNC Primary source HGNC:HGNC:1678 See related Ensembl:ENSG00000010610 MIM:186940; AllianceGenome:HGNC:1678 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T4; IMD79; Leu-3; OKT4D; CD4mut Summary This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis. Expression Broad expression in spleen (RPKM 82.4), lymph node (RPKM 55.1) and 19 other tissues See more Orthologs mouse all
CD40, Official Symbol CD40provided by HGNC Official Full Name CD40 moleculeprovided by HGNC Primary source HGNC:HGNC:11919 See related Ensembl:ENSG00000101017 MIM:109535; AllianceGenome:HGNC:11919 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p50; Bp50; CDW40; TNFRSF5 Summary This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] Expression Broad expression in lymph node (RPKM 19.2), appendix (RPKM 13.7) and 23 other tissues See more Orthologs mouse all
CD40LG, Official Symbol CD40LGprovided by HGNC Official Full Name CD40 ligandprovided by HGNC Primary source HGNC:HGNC:11935 See related Ensembl:ENSG00000102245 MIM:300386; AllianceGenome:HGNC:11935 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L Summary The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 7.7), appendix (RPKM 4.4) and 10 other tissues See more Orthologs mouse all
CD44, Official Symbol CD44provided by HGNC Official Full Name CD44 molecule (Indian blood group)provided by HGNC Primary source HGNC:HGNC:1681 See related Ensembl:ENSG00000026508 MIM:107269; AllianceGenome:HGNC:1681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; H-CAM; HCELL; ECM-III; HUTCH-1; HUTCH-I; ECMR-III; Hermes-1 Summary The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] Expression Broad expression in skin (RPKM 96.7), appendix (RPKM 60.6) and 19 other tissues See more Orthologs mouse all
CD46, Official Symbol CD46provided by HGNC Official Full Name CD46 moleculeprovided by HGNC Primary source HGNC:HGNC:6953 See related Ensembl:ENSG00000117335 MIM:120920; AllianceGenome:HGNC:6953 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCP; TLX; AHUS2; MIC10; TRA2.10 Summary The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] Expression Ubiquitous expression in adrenal (RPKM 99.0), placenta (RPKM 71.8) and 25 other tissues See more Orthologs mouse all
CD46P1, Official Symbol CD46P1provided by HGNC Official Full Name CD46 molecule pseudogene 1provided by HGNC Primary source HGNC:HGNC:6959 See related Ensembl:ENSG00000244703 AllianceGenome:HGNC:6959 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCPL; CD46P; MCPL1
CD47, Official Symbol CD47provided by HGNC Official Full Name CD47 moleculeprovided by HGNC Primary source HGNC:HGNC:1682 See related Ensembl:ENSG00000196776 MIM:601028; AllianceGenome:HGNC:1682 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IAP; OA3; MER6 Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in lung (RPKM 24.2), brain (RPKM 20.9) and 24 other tissues See more Orthologs mouse all
CD48, Official Symbol CD48provided by HGNC Official Full Name CD48 moleculeprovided by HGNC Primary source HGNC:HGNC:1683 See related Ensembl:ENSG00000117091 MIM:109530; AllianceGenome:HGNC:1683 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102 Summary This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Biased expression in lymph node (RPKM 70.5), spleen (RPKM 47.2) and 9 other tissues See more Orthologs mouse all
CD5, Official Symbol CD5provided by HGNC Official Full Name CD5 moleculeprovided by HGNC Primary source HGNC:HGNC:1685 See related Ensembl:ENSG00000110448 MIM:153340; AllianceGenome:HGNC:1685 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T1; LEU1 Summary This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016] Expression Biased expression in lymph node (RPKM 19.1), appendix (RPKM 11.9) and 10 other tissues See more Orthologs mouse all
CD52, Official Symbol CD52provided by HGNC Official Full Name CD52 moleculeprovided by HGNC Primary source HGNC:HGNC:1804 See related Ensembl:ENSG00000169442 MIM:114280; AllianceGenome:HGNC:1804 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HE5; CDW52; EDDM5 Summary Involved in positive regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region and plasma membrane. Predicted to be intrinsic component of plasma membrane. Predicted to be active in sperm midpiece. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 265.0), spleen (RPKM 195.7) and 9 other tissues See more Orthologs mouse all
CD53, Official Symbol CD53provided by HGNC Official Full Name CD53 moleculeprovided by HGNC Primary source HGNC:HGNC:1686 See related Ensembl:ENSG00000143119 MIM:151525; AllianceGenome:HGNC:1686 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MOX44; TSPAN25 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Biased expression in lymph node (RPKM 181.8), appendix (RPKM 156.6) and 12 other tissues See more Orthologs mouse all
CD55, Official Symbol CD55provided by HGNC Official Full Name CD55 molecule (Cromer blood group)provided by HGNC Primary source HGNC:HGNC:2665 See related Ensembl:ENSG00000196352 MIM:125240; AllianceGenome:HGNC:2665 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CR; TC; DAF; CROM; CHAPLE Summary This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014] Expression Broad expression in lung (RPKM 90.6), adrenal (RPKM 63.8) and 23 other tissues See more Orthologs mouse all
CD58, Official Symbol CD58provided by HGNC Official Full Name CD58 moleculeprovided by HGNC Primary source HGNC:HGNC:1688 See related Ensembl:ENSG00000116815 MIM:153420; AllianceGenome:HGNC:1688 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ag3; LFA3; LFA-3 Summary This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] Expression Low expression observed in reference dataset See more Orthologs all
CD59, Official Symbol CD59provided by HGNC Official Full Name CD59 molecule (CD59 blood group)provided by HGNC Primary source HGNC:HGNC:1689 See related Ensembl:ENSG00000085063 MIM:107271; AllianceGenome:HGNC:1689 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20 Summary This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in gall bladder (RPKM 62.1), lung (RPKM 52.8) and 25 other tissues See more Orthologs all
CD5L, Official Symbol CD5Lprovided by HGNC Official Full Name CD5 molecule likeprovided by HGNC Primary source HGNC:HGNC:1690 See related Ensembl:ENSG00000073754 MIM:602592; AllianceGenome:HGNC:1690 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward spleen (RPKM 260.3) See more Orthologs mouse all
CD6, Official Symbol CD6provided by HGNC Official Full Name CD6 moleculeprovided by HGNC Primary source HGNC:HGNC:1691 See related Ensembl:ENSG00000013725 MIM:186720; AllianceGenome:HGNC:1691 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TP120 Summary This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Biased expression in lymph node (RPKM 22.7), appendix (RPKM 13.7) and 9 other tissues See more Orthologs mouse all
CD63, Official Symbol CD63provided by HGNC Official Full Name CD63 moleculeprovided by HGNC Primary source HGNC:HGNC:1692 See related Ensembl:ENSG00000135404 MIM:155740; AllianceGenome:HGNC:1692 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD1; MLA1; ME491; HOP-26; OMA81H; Pltgp40; TSPAN30 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in fat (RPKM 184.8), colon (RPKM 181.1) and 25 other tissues See more Orthologs mouse all
CD68, Official Symbol CD68provided by HGNC Official Full Name CD68 moleculeprovided by HGNC Primary source HGNC:HGNC:1693 See related Ensembl:ENSG00000129226 MIM:153634; AllianceGenome:HGNC:1693 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP110; LAMP4; SCARD1 Summary This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 159.3), lung (RPKM 115.5) and 19 other tissues See more Orthologs mouse all
CD69, Official Symbol CD69provided by HGNC Official Full Name CD69 moleculeprovided by HGNC Primary source HGNC:HGNC:1694 See related Ensembl:ENSG00000110848 MIM:107273; AllianceGenome:HGNC:1694 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26 Summary This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011] Expression Biased expression in bone marrow (RPKM 55.9), lymph node (RPKM 41.3) and 13 other tissues See more Orthologs all
CD7, Official Symbol CD7provided by HGNC Official Full Name CD7 moleculeprovided by HGNC Primary source HGNC:HGNC:1695 See related Ensembl:ENSG00000173762 MIM:186820; AllianceGenome:HGNC:1695 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP40; TP41; Tp40; LEU-9 Summary This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 5.2), appendix (RPKM 4.1) and 12 other tissues See more Orthologs mouse all
CD70, Official Symbol CD70provided by HGNC Official Full Name CD70 moleculeprovided by HGNC Primary source HGNC:HGNC:11937 See related Ensembl:ENSG00000125726 MIM:602840; AllianceGenome:HGNC:11937 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
CD72, Official Symbol CD72provided by HGNC Official Full Name CD72 moleculeprovided by HGNC Primary source HGNC:HGNC:1696 See related Ensembl:ENSG00000137101 MIM:107272; AllianceGenome:HGNC:1696 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYB2; CD72b Summary Predicted to enable signaling receptor binding activity. Predicted to be involved in cell adhesion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 32.2), spleen (RPKM 30.4) and 4 other tissues See more Orthologs mouse all
CD74, Official Symbol CD74provided by HGNC Official Full Name CD74 moleculeprovided by HGNC Primary source HGNC:HGNC:1697 See related Ensembl:ENSG00000019582 MIM:142790; AllianceGenome:HGNC:1697 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as II; p33; CLIP; DHLAG; HLADG; Ia-GAMMA Summary The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] Expression Broad expression in spleen (RPKM 1835.3), lymph node (RPKM 1421.7) and 24 other tissues See more Orthologs mouse all
CD79A, Official Symbol CD79Aprovided by HGNC Official Full Name CD79a moleculeprovided by HGNC Primary source HGNC:HGNC:1698 See related Ensembl:ENSG00000105369 MIM:112205; AllianceGenome:HGNC:1698 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGA; MB1; MB-1; IGAlpha Summary The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 171.0), spleen (RPKM 119.8) and 7 other tissues See more Orthologs mouse all
CD79B, Official Symbol CD79Bprovided by HGNC Official Full Name CD79b moleculeprovided by HGNC Primary source HGNC:HGNC:1699 See related Ensembl:ENSG00000007312 MIM:147245; AllianceGenome:HGNC:1699 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B29; IGB; AGM6; Igbeta Summary The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues See more Orthologs mouse all
CD80, Official Symbol CD80provided by HGNC Official Full Name CD80 moleculeprovided by HGNC Primary source HGNC:HGNC:1700 See related Ensembl:ENSG00000121594 MIM:112203; AllianceGenome:HGNC:1700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1 Summary The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in appendix (RPKM 2.0), lymph node (RPKM 1.9) and 24 other tissues See more Orthologs mouse all
CD81, Official Symbol CD81provided by HGNC Official Full Name CD81 moleculeprovided by HGNC Primary source HGNC:HGNC:1701 See related Ensembl:ENSG00000110651 MIM:186845; AllianceGenome:HGNC:1701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S5.7; CVID6; TAPA1; TSPAN28 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in endometrium (RPKM 241.8), fat (RPKM 237.1) and 25 other tissues See more Orthologs mouse all
CD81-AS1, Official Symbol CD81-AS1provided by HGNC Official Full Name CD81 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49384 See related Ensembl:ENSG00000238184 AllianceGenome:HGNC:49384 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in fat (RPKM 5.1), endometrium (RPKM 3.8) and 25 other tissues See more
CD82, Official Symbol CD82provided by HGNC Official Full Name CD82 moleculeprovided by HGNC Primary source HGNC:HGNC:6210 See related Ensembl:ENSG00000085117 MIM:600623; AllianceGenome:HGNC:6210 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27 Summary This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 44.7), bone marrow (RPKM 32.0) and 25 other tissues See more Orthologs mouse all
CD83, Official Symbol CD83provided by HGNC Official Full Name CD83 moleculeprovided by HGNC Primary source HGNC:HGNC:1703 See related Ensembl:ENSG00000112149 MIM:604534; AllianceGenome:HGNC:1703 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BL11; HB15 Summary The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Broad expression in bone marrow (RPKM 72.2), lymph node (RPKM 25.8) and 14 other tissues See more Orthologs mouse all
CD83P1, Official Symbol CD83P1provided by HGNC Official Full Name CD83 molecule pseudogene 1provided by HGNC Primary source HGNC:HGNC:13946 See related Ensembl:ENSG00000219738 AllianceGenome:HGNC:13946 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD83P; HB15p; b34I8.3
CD84, Official Symbol CD84provided by HGNC Official Full Name CD84 moleculeprovided by HGNC Primary source HGNC:HGNC:1704 See related Ensembl:ENSG00000066294 MIM:604513; AllianceGenome:HGNC:1704 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LY9B; hCD84; mCD84; SLAMF5 Summary This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] Expression Broad expression in lymph node (RPKM 12.0), appendix (RPKM 11.0) and 19 other tissues See more Orthologs mouse all
CD84P1, Official Symbol CD84P1provided by HGNC Official Full Name CD84 pseudogene 1provided by HGNC Primary source HGNC:HGNC:55159 Gene type pseudo Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
CD86, Official Symbol CD86provided by HGNC Official Full Name CD86 moleculeprovided by HGNC Primary source HGNC:HGNC:1705 See related Ensembl:ENSG00000114013 MIM:601020; AllianceGenome:HGNC:1705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B70; B7-2; B7.2; LAB72; CD28LG2 Summary This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011] Expression Broad expression in appendix (RPKM 16.6), lymph node (RPKM 11.0) and 16 other tissues See more Orthologs mouse all
CD8A, Official Symbol CD8Aprovided by HGNC Official Full Name CD8 subunit alphaprovided by HGNC Primary source HGNC:HGNC:1706 See related Ensembl:ENSG00000153563 MIM:186910; AllianceGenome:HGNC:1706 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD8; p32; Leu2; CD8alpha Summary The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis. Expression Biased expression in spleen (RPKM 38.0), lymph node (RPKM 12.5) and 8 other tissues See more Orthologs mouse all
CD8B, Official Symbol CD8Bprovided by HGNC Official Full Name CD8 subunit betaprovided by HGNC Primary source HGNC:HGNC:1707 See related Ensembl:ENSG00000172116 MIM:186730; AllianceGenome:HGNC:1707 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LY3; P37; LEU2; LYT3; Ly-3; CD8B1; CD8beta Summary The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010] Expression Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues See more Orthologs mouse all
CD8B2, Official Symbol CD8B2provided by HGNC Official Full Name CD8B family member 2provided by HGNC Primary source HGNC:HGNC:1708 See related Ensembl:ENSG00000254126 AllianceGenome:HGNC:1708 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD8BP Summary Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in adaptive immune response and regulation of immune response. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
CD9, Official Symbol CD9provided by HGNC Official Full Name CD9 moleculeprovided by HGNC Primary source HGNC:HGNC:1709 See related Ensembl:ENSG00000010278 MIM:143030; AllianceGenome:HGNC:1709 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIC3; MRP-1; BTCC-1; DRAP-27; TSPAN29; TSPAN-29 Summary This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011] Expression Broad expression in esophagus (RPKM 210.8), prostate (RPKM 168.1) and 21 other tissues See more Orthologs mouse all