psui3905/ncbi_genes_summary huggingface dataset:
NOC2LP1, Official Symbol NOC2LP1provided by HGNC Official Full Name NOC2 like nucleolar associated transcriptional repressor pseudogene 1provided by HGNC Primary source HGNC:HGNC:52285 See related Ensembl:ENSG00000213225 AllianceGenome:HGNC:52285 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NOC3L, Official Symbol NOC3Lprovided by HGNC Official Full Name NOC3 like DNA replication regulatorprovided by HGNC Primary source HGNC:HGNC:24034 See related Ensembl:ENSG00000173145 MIM:610769; AllianceGenome:HGNC:24034 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD24; FAD24; C10orf117 Summary Enables RNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within fat cell differentiation. Located in mitochondrion; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.2), testis (RPKM 6.7) and 25 other tissues See more Orthologs mouse all
NOC4L, Official Symbol NOC4Lprovided by HGNC Official Full Name nucleolar complex associated 4 homologprovided by HGNC Primary source HGNC:HGNC:28461 See related Ensembl:ENSG00000184967 MIM:612819; AllianceGenome:HGNC:28461 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOC4; NET49; UTP19 Summary Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 11.3), spleen (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
NOCT, Official Symbol NOCTprovided by HGNC Official Full Name nocturninprovided by HGNC Primary source HGNC:HGNC:14254 See related Ensembl:ENSG00000151014 MIM:608468; AllianceGenome:HGNC:14254 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOC; CCR4L; Ccr4c; CCRN4L Summary The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 15.3), liver (RPKM 6.4) and 18 other tissues See more Orthologs mouse all
NOD1, Official Symbol NOD1provided by HGNC Official Full Name nucleotide binding oligomerization domain containing 1provided by HGNC Primary source HGNC:HGNC:16390 See related Ensembl:ENSG00000106100 MIM:605980; AllianceGenome:HGNC:16390 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CARD4; NLRC1; hNod1; CLR7.1 Summary This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in lung (RPKM 5.7), spleen (RPKM 4.5) and 24 other tissues See more Orthologs mouse all
NOD2, Official Symbol NOD2provided by HGNC Official Full Name nucleotide binding oligomerization domain containing 2provided by HGNC Primary source HGNC:HGNC:5331 See related Ensembl:ENSG00000167207 MIM:605956; AllianceGenome:HGNC:5331 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1 Summary This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014] Expression Broad expression in bone marrow (RPKM 3.3), appendix (RPKM 2.5) and 16 other tissues See more Orthologs mouse all
NODAL, Official Symbol NODALprovided by HGNC Official Full Name nodal growth differentiation factorprovided by HGNC Primary source HGNC:HGNC:7865 See related Ensembl:ENSG00000156574 MIM:601265; AllianceGenome:HGNC:7865 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTX5 Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016] Expression Low expression observed in reference dataset See more Orthologs mouse all
NOG, Official Symbol NOGprovided by HGNC Official Full Name nogginprovided by HGNC Primary source HGNC:HGNC:7866 See related Ensembl:ENSG00000183691 MIM:602991; AllianceGenome:HGNC:7866 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SYM1; SYNS1; SYNS1A Summary The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008] Orthologs mouse all
NOL10, Official Symbol NOL10provided by HGNC Official Full Name nucleolar protein 10provided by HGNC Primary source HGNC:HGNC:25862 See related Ensembl:ENSG00000115761 MIM:616197; AllianceGenome:HGNC:25862 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PQBP5 Summary Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 4.5), adrenal (RPKM 4.0) and 25 other tissues See more Orthologs mouse all
NOL11, Official Symbol NOL11provided by HGNC Official Full Name nucleolar protein 11provided by HGNC Primary source HGNC:HGNC:24557 See related Ensembl:ENSG00000130935 MIM:615366; AllianceGenome:HGNC:24557 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity. Involved in maturation of SSU-rRNA and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Located in nucleolus. Part of t-UTP complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 16.4), appendix (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
NOL12, Official Symbol NOL12provided by HGNC Official Full Name nucleolar protein 12provided by HGNC Primary source HGNC:HGNC:28585 See related Ensembl:ENSG00000273899 AllianceGenome:HGNC:28585 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Nop25; dJ37E16.7 Summary Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.5), skin (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
NOL3, Official Symbol NOL3provided by HGNC Official Full Name nucleolar protein 3provided by HGNC Primary source HGNC:HGNC:7869 See related Ensembl:ENSG00000140939 MIM:605235; AllianceGenome:HGNC:7869 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC; FCM; MYP; NOP; NOP30; MYOCL1 Summary This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Expression Ubiquitous expression in skin (RPKM 15.7), prostate (RPKM 15.6) and 24 other tissues See more Orthologs mouse all
NOL4, Official Symbol NOL4provided by HGNC Official Full Name nucleolar protein 4provided by HGNC Primary source HGNC:HGNC:7870 See related Ensembl:ENSG00000101746 MIM:603577; AllianceGenome:HGNC:7870 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOLP; CT125; HRIHFB2255 Summary Predicted to enable RNA binding activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 3.8), testis (RPKM 3.2) and 4 other tissues See more Orthologs mouse all
NOL4L, Official Symbol NOL4Lprovided by HGNC Official Full Name nucleolar protein 4 likeprovided by HGNC Primary source HGNC:HGNC:16106 See related Ensembl:ENSG00000197183 MIM:618893; AllianceGenome:HGNC:16106 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C20orf112; C20orf113 Summary Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 8.2), small intestine (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
NOL4L-DT, Official Symbol NOL4L-DTprovided by HGNC Official Full Name NOL4L divergent transcriptprovided by HGNC Primary source HGNC:HGNC:44310 See related Ensembl:ENSG00000204393 AllianceGenome:HGNC:44310 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
NOL6, Official Symbol NOL6provided by HGNC Official Full Name nucleolar protein 6provided by HGNC Primary source HGNC:HGNC:19910 See related Ensembl:ENSG00000165271 MIM:611532; AllianceGenome:HGNC:19910 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRAP; UTP22; bA311H10.1 Summary The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 9.6), skin (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
NOL7, Official Symbol NOL7provided by HGNC Official Full Name nucleolar protein 7provided by HGNC Primary source HGNC:HGNC:21040 See related Ensembl:ENSG00000225921 MIM:611533; AllianceGenome:HGNC:21040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PQBP3; RARG-1; C6orf90; dJ223E5.2 Summary The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in testis (RPKM 25.5), thyroid (RPKM 22.2) and 25 other tissues See more Orthologs mouse all
NOL8, Official Symbol NOL8provided by HGNC Official Full Name nucleolar protein 8provided by HGNC Primary source HGNC:HGNC:23387 See related Ensembl:ENSG00000198000 MIM:611534; AllianceGenome:HGNC:23387 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOP132; C9orf34; bA62C3.3; bA62C3.4 Summary NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in lymph node (RPKM 8.0), appendix (RPKM 6.7) and 25 other tissues See more Orthologs mouse all
NOL8P1, Official Symbol NOL8P1provided by HGNC Official Full Name nucleolar protein 8 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49557 See related Ensembl:ENSG00000248327 AllianceGenome:HGNC:49557 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NOL9, Official Symbol NOL9provided by HGNC Official Full Name nucleolar protein 9provided by HGNC Primary source HGNC:HGNC:26265 See related Ensembl:ENSG00000162408 MIM:620304; AllianceGenome:HGNC:26265 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Grc3; NET6 Summary Enables polynucleotide 5'-hydroxyl-kinase activity. Involved in maturation of 5.8S rRNA. Located in intermediate filament cytoskeleton and nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 3.0), bone marrow (RPKM 2.3) and 25 other tissues See more Orthologs mouse all
NOLC1, Official Symbol NOLC1provided by HGNC Official Full Name nucleolar and coiled-body phosphoprotein 1provided by HGNC Primary source HGNC:HGNC:15608 See related Ensembl:ENSG00000166197 MIM:602394; AllianceGenome:HGNC:15608 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P130; Srp40; NOPP130; NOPP140; NS5ATP13 Summary Enables protein heterodimerization activity and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 23.0), thyroid (RPKM 22.8) and 25 other tissues See more Orthologs mouse all
NOLC1P1, Official Symbol NOLC1P1provided by HGNC Official Full Name NOLC1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54890 See related Ensembl:ENSG00000225271 AllianceGenome:HGNC:54890 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NOM1, Official Symbol NOM1provided by HGNC Official Full Name nucleolar protein with MIF4G domain 1provided by HGNC Primary source HGNC:HGNC:13244 See related Ensembl:ENSG00000146909 MIM:611269; AllianceGenome:HGNC:13244 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SGD1; C7orf3; PPP1R113 Summary Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
NOMO1, Official Symbol NOMO1provided by HGNC Official Full Name NODAL modulator 1provided by HGNC Primary source HGNC:HGNC:30060 See related Ensembl:ENSG00000103512 MIM:609157; AllianceGenome:HGNC:30060 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PM5; Nomo Summary This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 58.5), heart (RPKM 50.3) and 25 other tissues See more Orthologs all
NOMO2, Official Symbol NOMO2provided by HGNC Official Full Name NODAL modulator 2provided by HGNC Primary source HGNC:HGNC:22652 See related Ensembl:ENSG00000185164 MIM:609158; AllianceGenome:HGNC:22652 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PM5; Nomo Summary This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Annotation information Annotation category: suggests misassembly Expression Ubiquitous expression in brain (RPKM 58.0), heart (RPKM 50.7) and 25 other tissues See more Orthologs all
NOMO3, Official Symbol NOMO3provided by HGNC Official Full Name NODAL modulator 3provided by HGNC Primary source HGNC:HGNC:25242 See related Ensembl:ENSG00000103226 MIM:609159; AllianceGenome:HGNC:25242 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Nomo Summary This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 58.4), heart (RPKM 50.4) and 25 other tissues See more
NONO, Official Symbol NONOprovided by HGNC Official Full Name non-POU domain containing octamer bindingprovided by HGNC Primary source HGNC:HGNC:7871 See related Ensembl:ENSG00000147140 MIM:300084; AllianceGenome:HGNC:7871 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114 Summary This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009] Expression Ubiquitous expression in ovary (RPKM 81.7), lymph node (RPKM 64.3) and 25 other tissues See more Orthologs mouse all
NOP10, Official Symbol NOP10provided by HGNC Official Full Name NOP10 ribonucleoproteinprovided by HGNC Primary source HGNC:HGNC:14378 See related Ensembl:ENSG00000182117 MIM:606471; AllianceGenome:HGNC:14378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKCB1; NOLA3; CHINE2; NOP10P; PFBMFT9 Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 45.9), spleen (RPKM 43.6) and 25 other tissues See more Orthologs mouse all
NOP14, Official Symbol NOP14provided by HGNC Official Full Name NOP14 nucleolar proteinprovided by HGNC Primary source HGNC:HGNC:16821 See related Ensembl:ENSG00000087269 MIM:611526; AllianceGenome:HGNC:16821 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UTP2; NOL14; C4orf9; RES425; RES4-25 Summary This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in lymph node (RPKM 10.9), appendix (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
NOP16, Official Symbol NOP16provided by HGNC Official Full Name NOP16 nucleolar proteinprovided by HGNC Primary source HGNC:HGNC:26934 See related Ensembl:ENSG00000048162 MIM:612861; AllianceGenome:HGNC:26934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSPC111; HSPC185 Summary This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in colon (RPKM 17.7), appendix (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
NOP2, Official Symbol NOP2provided by HGNC Official Full Name NOP2 nucleolar proteinprovided by HGNC Primary source HGNC:HGNC:7867 See related Ensembl:ENSG00000111641 MIM:164031; AllianceGenome:HGNC:7867 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOL1; p120; NSUN1; NOP120 Summary Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 12.9), bone marrow (RPKM 12.9) and 25 other tissues See more Orthologs mouse all
NOP53, Official Symbol NOP53provided by HGNC Official Full Name NOP53 ribosome biogenesis factorprovided by HGNC Primary source HGNC:HGNC:4333 See related Ensembl:ENSG00000105373 MIM:605691; AllianceGenome:HGNC:4333 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PICT1; PICT-1; GLTSCR2 Summary Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabolic process; and regulation of intracellular signal transduction. Located in cytosol; fibrillar center; and nucleoplasm. Colocalizes with rDNA heterochromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 175.8), spleen (RPKM 136.0) and 25 other tissues See more Orthologs mouse all
NOP53-AS1, Official Symbol NOP53-AS1provided by HGNC Official Full Name NOP53 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51587 See related Ensembl:ENSG00000269656 AllianceGenome:HGNC:51587 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLTSCR2-AS1 Expression Ubiquitous expression in skin (RPKM 3.3), lymph node (RPKM 2.7) and 25 other tissues See more
NOP56, Official Symbol NOP56provided by HGNC Official Full Name NOP56 ribonucleoproteinprovided by HGNC Primary source HGNC:HGNC:15911 See related Ensembl:ENSG00000101361 MIM:614154; AllianceGenome:HGNC:15911 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOL5A; SCA36 Summary Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in lymph node (RPKM 34.3), appendix (RPKM 31.9) and 25 other tissues See more Orthologs mouse all
NOP56P2, Official Symbol NOP56P2provided by HGNC Official Full Name NOP56 ribonucleoprotein pseudogene 2provided by HGNC Primary source HGNC:HGNC:49800 See related Ensembl:ENSG00000226626 AllianceGenome:HGNC:49800 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NOP58, Official Symbol NOP58provided by HGNC Official Full Name NOP58 ribonucleoproteinprovided by HGNC Primary source HGNC:HGNC:29926 See related Ensembl:ENSG00000055044 MIM:616742; AllianceGenome:HGNC:29926 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOP5; HSPC120; NOP5/NOP58 Summary The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in bone marrow (RPKM 29.6), lymph node (RPKM 29.1) and 25 other tissues See more Orthologs mouse all
NOP9, Official Symbol NOP9provided by HGNC Official Full Name NOP9 nucleolar proteinprovided by HGNC Primary source HGNC:HGNC:19826 See related Ensembl:ENSG00000196943 MIM:618308; AllianceGenome:HGNC:19826 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HP08474; C14orf21 Summary Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 25.7), liver (RPKM 25.0) and 25 other tissues See more Orthologs mouse all
NORAD, Official Symbol NORADprovided by HGNC Official Full Name non-coding RNA activated by DNA damageprovided by HGNC Primary source HGNC:HGNC:44311 See related Ensembl:ENSG00000260032 MIM:617037; AllianceGenome:HGNC:44311 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00657
NOS1, Official Symbol NOS1provided by HGNC Official Full Name nitric oxide synthase 1provided by HGNC Primary source HGNC:HGNC:7872 See related Ensembl:ENSG00000089250 MIM:163731; AllianceGenome:HGNC:7872 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOS; bNOS; nNOS; IHPS1; N-NOS; NC-NOS Summary The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011] Expression Biased expression in brain (RPKM 1.1), kidney (RPKM 1.0) and 11 other tissues See more Orthologs mouse all
NOS1AP, Official Symbol NOS1APprovided by HGNC Official Full Name nitric oxide synthase 1 adaptor proteinprovided by HGNC Primary source HGNC:HGNC:16859 See related Ensembl:ENSG00000198929 MIM:605551; AllianceGenome:HGNC:16859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAPON; NPHS22; 6330408P19Rik Summary This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009] Expression Biased expression in brain (RPKM 5.4), adrenal (RPKM 1.1) and 11 other tissues See more Orthologs mouse all
NOS2, Official Symbol NOS2provided by HGNC Official Full Name nitric oxide synthase 2provided by HGNC Primary source HGNC:HGNC:7873 See related Ensembl:ENSG00000007171 MIM:163730; AllianceGenome:HGNC:7873 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOS; INOS; NOS2A; HEP-NOS Summary Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] Expression Biased expression in small intestine (RPKM 10.3), appendix (RPKM 7.9) and 5 other tissues See more Orthologs mouse all
NOS2P4, Official Symbol NOS2P4provided by HGNC Official Full Name nitric oxide synthase 2 pseudogene 4provided by HGNC Primary source HGNC:HGNC:50720 See related Ensembl:ENSG00000264892 AllianceGenome:HGNC:50720 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NOS3, Official Symbol NOS3provided by HGNC Official Full Name nitric oxide synthase 3provided by HGNC Primary source HGNC:HGNC:7876 See related Ensembl:ENSG00000164867 MIM:163729; AllianceGenome:HGNC:7876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as eNOS; ECNOS Summary Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016] Expression Biased expression in spleen (RPKM 28.4), placenta (RPKM 4.0) and 11 other tissues See more Orthologs mouse all
NOSIP, Official Symbol NOSIPprovided by HGNC Official Full Name nitric oxide synthase interacting proteinprovided by HGNC Primary source HGNC:HGNC:17946 See related Ensembl:ENSG00000142546 MIM:616759; AllianceGenome:HGNC:17946 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-25 Summary The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in testis (RPKM 21.1), lymph node (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
NOSTRIN, Official Symbol NOSTRINprovided by HGNC Official Full Name nitric oxide synthase traffickingprovided by HGNC Primary source HGNC:HGNC:20203 See related Ensembl:ENSG00000163072 MIM:607496; AllianceGenome:HGNC:20203 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DaIP2 Summary Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in fat (RPKM 8.2), lung (RPKM 6.6) and 24 other tissues See more Orthologs mouse all
NOTCH1, Official Symbol NOTCH1provided by HGNC Official Full Name notch receptor 1provided by HGNC Primary source HGNC:HGNC:7881 See related Ensembl:ENSG00000148400 MIM:190198; AllianceGenome:HGNC:7881 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hN1; AOS5; TAN1; AOVD1 Summary This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in fat (RPKM 9.4), spleen (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
NOTCH2, Official Symbol NOTCH2provided by HGNC Official Full Name notch receptor 2provided by HGNC Primary source HGNC:HGNC:7882 See related Ensembl:ENSG00000134250 MIM:600275; AllianceGenome:HGNC:7882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hN2; AGS2; HJCYS Summary This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in testis (RPKM 12.9), ovary (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
NOTCH2NLA, Official Symbol NOTCH2NLAprovided by HGNC Official Full Name notch 2 N-terminal like Aprovided by HGNC Primary source HGNC:HGNC:31862 See related Ensembl:ENSG00000264343 MIM:618023; AllianceGenome:HGNC:31862 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2N; NOTCH2NL Summary Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 12.1), skin (RPKM 6.6) and 25 other tissues See more
NOTCH2NLB, Official Symbol NOTCH2NLBprovided by HGNC Official Full Name notch 2 N-terminal like Bprovided by HGNC Primary source HGNC:HGNC:53923 See related Ensembl:ENSG00000286019 MIM:618024; AllianceGenome:HGNC:53923 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2N; NOTCH2NL; NOTCH2NLA Summary Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.7), skin (RPKM 4.9) and 25 other tissues See more
NOTCH2NLC, Official Symbol NOTCH2NLCprovided by HGNC Official Full Name notch 2 N-terminal like Cprovided by HGNC Primary source HGNC:HGNC:53924 See related Ensembl:ENSG00000286219 MIM:618025; AllianceGenome:HGNC:53924 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N2N; ETM6; NIID; OPDM3; NOTCH2NL; NOTCH2NLA Summary Predicted to enable calcium ion binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. Implicated in essential tremor. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 3.9), bone marrow (RPKM 2.8) and 25 other tissues See more