psui3905/ncbi_genes_summary huggingface dataset:
SLC9A4, Official Symbol SLC9A4provided by HGNC Official Full Name solute carrier family 9 member A4provided by HGNC Primary source HGNC:HGNC:11077 See related Ensembl:ENSG00000180251 MIM:600531; AllianceGenome:HGNC:11077 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHE4 Summary Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within epithelial cell development and gastric acid secretion. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and vacuolar membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in stomach (RPKM 24.9) and kidney (RPKM 5.2) See more Orthologs mouse all
SLC9A5, Official Symbol SLC9A5provided by HGNC Official Full Name solute carrier family 9 member A5provided by HGNC Primary source HGNC:HGNC:11078 See related Ensembl:ENSG00000135740 MIM:600477; AllianceGenome:HGNC:11078 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHE5 Summary Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Implicated in end stage renal disease. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in spleen (RPKM 6.3), testis (RPKM 2.2) and 7 other tissues See more Orthologs mouse all
SLC9A6, Official Symbol SLC9A6provided by HGNC Official Full Name solute carrier family 9 member A6provided by HGNC Primary source HGNC:HGNC:11079 See related Ensembl:ENSG00000198689 MIM:300231; AllianceGenome:HGNC:11079 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRSA; NHE6; MRXSCH Summary This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] Expression Ubiquitous expression in brain (RPKM 26.2), adrenal (RPKM 4.9) and 23 other tissues See more Orthologs mouse all
SLC9A7, Official Symbol SLC9A7provided by HGNC Official Full Name solute carrier family 9 member A7provided by HGNC Primary source HGNC:HGNC:17123 See related Ensembl:ENSG00000065923 MIM:300368; AllianceGenome:HGNC:17123 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHE7; NHE-7; MRX108; SLC9A6 Summary This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] Expression Broad expression in brain (RPKM 6.0), lymph node (RPKM 3.6) and 24 other tissues See more Orthologs mouse all
SLC9A7P1, Official Symbol SLC9A7P1provided by HGNC Official Full Name solute carrier family 9 member 7 pseudogene 1provided by HGNC Primary source HGNC:HGNC:32679 See related Ensembl:ENSG00000227825 AllianceGenome:HGNC:32679 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SLC9A8, Official Symbol SLC9A8provided by HGNC Official Full Name solute carrier family 9 member A8provided by HGNC Primary source HGNC:HGNC:20728 See related Ensembl:ENSG00000197818 MIM:612730; AllianceGenome:HGNC:20728 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHE8; NHE-8 Summary Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009] Expression Ubiquitous expression in bone marrow (RPKM 8.0), testis (RPKM 5.3) and 25 other tissues See more Orthologs mouse all
SLC9A9, Official Symbol SLC9A9provided by HGNC Official Full Name solute carrier family 9 member A9provided by HGNC Primary source HGNC:HGNC:20653 See related Ensembl:ENSG00000181804 MIM:608396; AllianceGenome:HGNC:20653 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHE9; AUTS16 Summary This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity disorder. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in lymph node (RPKM 3.2), esophagus (RPKM 3.0) and 24 other tissues See more Orthologs mouse all
SLC9A9-AS1, Official Symbol SLC9A9-AS1provided by HGNC Official Full Name SLC9A9 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40928 See related Ensembl:ENSG00000240012 AllianceGenome:HGNC:40928 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
SLC9B1, Official Symbol SLC9B1provided by HGNC Official Full Name solute carrier family 9 member B1provided by HGNC Primary source HGNC:HGNC:24244 See related Ensembl:ENSG00000164037 MIM:611527; AllianceGenome:HGNC:24244 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHA1; NHEDC1 Summary The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] Expression Broad expression in testis (RPKM 16.0), kidney (RPKM 1.8) and 17 other tissues See more Orthologs mouse all
SLC9B1P1, Official Symbol SLC9B1P1provided by HGNC Official Full Name solute carrier family 9 member B1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:37492 See related Ensembl:ENSG00000183704 AllianceGenome:HGNC:37492 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHEDC1P1 Summary Predicted to enable solute:proton antiporter activity. Predicted to be involved in proton transmembrane transport and sodium ion transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
SLC9B1P2, Official Symbol SLC9B1P2provided by HGNC Official Full Name solute carrier family 9 member B1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:37493 See related Ensembl:ENSG00000214329 AllianceGenome:HGNC:37493 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHEDC1P2
SLC9B2, Official Symbol SLC9B2provided by HGNC Official Full Name solute carrier family 9 member B2provided by HGNC Primary source HGNC:HGNC:25143 See related Ensembl:ENSG00000164038 MIM:611789; AllianceGenome:HGNC:25143 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHA2; NHE10; NHEDC2 Summary Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008] Expression Broad expression in brain (RPKM 4.9), liver (RPKM 4.7) and 21 other tissues See more Orthologs mouse all
SLC9C1, Official Symbol SLC9C1provided by HGNC Official Full Name solute carrier family 9 member C1provided by HGNC Primary source HGNC:HGNC:31401 See related Ensembl:ENSG00000172139 MIM:612738; AllianceGenome:HGNC:31401 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHE; NHE-10; SLC9A10; sperm-NHE Summary Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within flagellated sperm motility. Predicted to be located in motile cilium. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 3.5) and skin (RPKM 0.5) See more Orthologs mouse all
SLC9C2, Official Symbol SLC9C2provided by HGNC Official Full Name solute carrier family 9 member C2 (putative)provided by HGNC Primary source HGNC:HGNC:28664 See related Ensembl:ENSG00000162753 MIM:620338; AllianceGenome:HGNC:28664 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHE11; SLC9A11 Summary Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 4.6) See more Orthologs mouse all
SLCO1A2, Official Symbol SLCO1A2provided by HGNC Official Full Name solute carrier organic anion transporter family member 1A2provided by HGNC Primary source HGNC:HGNC:10956 See related Ensembl:ENSG00000084453 MIM:602883; AllianceGenome:HGNC:10956 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OATP; OATP-A; OATP1A2; SLC21A3 Summary This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008] Expression Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues See more Orthologs all
SLCO1B1, Official Symbol SLCO1B1provided by HGNC Official Full Name solute carrier organic anion transporter family member 1B1provided by HGNC Primary source HGNC:HGNC:10959 See related Ensembl:ENSG00000134538 MIM:604843; AllianceGenome:HGNC:10959 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6 Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] Expression Restricted expression toward liver (RPKM 119.3) See more Orthologs all
SLCO1B3, Official Symbol SLCO1B3provided by HGNC Official Full Name solute carrier organic anion transporter family member 1B3provided by HGNC Primary source HGNC:HGNC:10961 See related Ensembl:ENSG00000111700 MIM:605495; AllianceGenome:HGNC:10961 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LST3; HBLRR; LST-2; OATP8; OATP-8; OATP1B3; SLC21A8; LST-3TM13 Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017] Expression Restricted expression toward liver (RPKM 30.2) See more Orthologs mouse all
SLCO1B3-SLCO1B7, Official Symbol SLCO1B3-SLCO1B7provided by HGNC Official Full Name SLCO1B3-SLCO1B7 readthroughprovided by HGNC Primary source HGNC:HGNC:54403 See related Ensembl:ENSG00000257046 AllianceGenome:HGNC:54403 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LST-3TM12; OATP1B3-1B7 Summary This locus represents naturally occurring readthrough transcription between the neighboring SLCO1B3 (solute carrier organic anion transporter family member 1B3) and SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)) genes on chromosome 12. The readthrough transcript encodes a protein that shares sequence identity with both the upstream and downstream genes. [provided by RefSeq, Jun 2019]
SLCO1C1, Official Symbol SLCO1C1provided by HGNC Official Full Name solute carrier organic anion transporter family member 1C1provided by HGNC Primary source HGNC:HGNC:13819 See related Ensembl:ENSG00000139155 MIM:613389; AllianceGenome:HGNC:13819 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OATP1; OATPF; OATP-F; OATP14; OATP1C1; OATPRP5; OATP-RP5; SLC21A14 Summary This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009] Expression Biased expression in brain (RPKM 4.0), fat (RPKM 0.5) and 3 other tissues See more Orthologs mouse all
SLCO2A1, Official Symbol SLCO2A1provided by HGNC Official Full Name solute carrier organic anion transporter family member 2A1provided by HGNC Primary source HGNC:HGNC:10955 See related Ensembl:ENSG00000174640 MIM:601460; AllianceGenome:HGNC:10955 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGT; MATR1; PHOAD; PHOAR2; OATP2A1; SLC21A2 Summary This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011] Expression Broad expression in lung (RPKM 28.3), thyroid (RPKM 27.0) and 20 other tissues See more Orthologs mouse all
SLCO2B1, Official Symbol SLCO2B1provided by HGNC Official Full Name solute carrier organic anion transporter family member 2B1provided by HGNC Primary source HGNC:HGNC:10962 See related Ensembl:ENSG00000137491 MIM:604988; AllianceGenome:HGNC:10962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OATPB; OATP-B; OATP2B1; SLC21A9 Summary This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010] Expression Broad expression in liver (RPKM 44.0), lung (RPKM 34.3) and 23 other tissues See more Orthologs mouse all
SLCO3A1, Official Symbol SLCO3A1provided by HGNC Official Full Name solute carrier organic anion transporter family member 3A1provided by HGNC Primary source HGNC:HGNC:10952 See related Ensembl:ENSG00000176463 MIM:612435; AllianceGenome:HGNC:10952 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OATPD; OATP-D; OATP3A1; OATPRP3; OATP-RP3; SLC21A11 Summary Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of protein phosphorylation; and prostaglandin transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 11.4), lung (RPKM 6.4) and 23 other tissues See more Orthologs mouse all
SLCO4A1, Official Symbol SLCO4A1provided by HGNC Official Full Name solute carrier organic anion transporter family member 4A1provided by HGNC Primary source HGNC:HGNC:10953 See related Ensembl:ENSG00000101187 MIM:612436; AllianceGenome:HGNC:10953 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POAT; OATP1; OATPE; OATP-E; OATP4A1; OATPRP1; SLC21A12 Summary Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 2.4), endometrium (RPKM 1.6) and 23 other tissues See more Orthologs mouse all
SLCO4A1-AS1, Official Symbol SLCO4A1-AS1provided by HGNC Official Full Name SLCO4A1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40537 See related Ensembl:ENSG00000232803 AllianceGenome:HGNC:40537 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in salivary gland (RPKM 4.9), esophagus (RPKM 3.0) and 20 other tissues See more
SLCO4C1, Official Symbol SLCO4C1provided by HGNC Official Full Name solute carrier organic anion transporter family member 4C1provided by HGNC Primary source HGNC:HGNC:23612 See related Ensembl:ENSG00000173930 MIM:609013; AllianceGenome:HGNC:23612 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OATPX; OATP-H; OATP-M1; OATP4C1; PRO2176; SLC21A20 Summary SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008] Expression Biased expression in kidney (RPKM 21.4), lung (RPKM 4.2) and 4 other tissues See more Orthologs mouse all
SLCO5A1, Official Symbol SLCO5A1provided by HGNC Official Full Name solute carrier organic anion transporter family member 5A1provided by HGNC Primary source HGNC:HGNC:19046 See related Ensembl:ENSG00000137571 MIM:613543; AllianceGenome:HGNC:19046 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OATPJ; OATP-J; OATP5A1; OATPRP4; OATP-RP4; SLC21A15 Summary Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in small intestine (RPKM 68.6), ovary (RPKM 66.6) and 25 other tissues See more Orthologs mouse all
SLCO6A1, Official Symbol SLCO6A1provided by HGNC Official Full Name solute carrier organic anion transporter family member 6A1provided by HGNC Primary source HGNC:HGNC:23613 See related Ensembl:ENSG00000205359 MIM:613365; AllianceGenome:HGNC:23613 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GST; CT48; OATPY; OATP-I; OATP6A1 Summary Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 7.9) See more Orthologs mouse all
SLED1, Gene symbol SLED1 Gene description proteoglycan 3, pro eosinophil major basic protein 2 pseudogene See related Ensembl:ENSG00000249138 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SLF1, Official Symbol SLF1provided by HGNC Official Full Name SMC5-SMC6 complex localization factor 1provided by HGNC Primary source HGNC:HGNC:25408 See related Ensembl:ENSG00000133302 MIM:618467; AllianceGenome:HGNC:25408 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRCTx; BRCTD1; ANKRD32 Summary Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in nucleoplasm and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 3.1), bone marrow (RPKM 1.1) and 23 other tissues See more Orthologs mouse all
SLF2, Official Symbol SLF2provided by HGNC Official Full Name SMC5-SMC6 complex localization factor 2provided by HGNC Primary source HGNC:HGNC:17814 See related Ensembl:ENSG00000119906 MIM:610348; AllianceGenome:HGNC:17814 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATELS1; C10orf6; FAM178A Summary Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in chromatin; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 12.5), ovary (RPKM 7.5) and 24 other tissues See more Orthologs mouse all
SLFN11, Official Symbol SLFN11provided by HGNC Official Full Name schlafen family member 11provided by HGNC Primary source HGNC:HGNC:26633 See related Ensembl:ENSG00000172716 MIM:614953; AllianceGenome:HGNC:26633 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLFN8/9 Summary Enables tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lung (RPKM 14.8), thyroid (RPKM 12.0) and 24 other tissues See more Orthologs all
SLFN12, Official Symbol SLFN12provided by HGNC Official Full Name schlafen family member 12provided by HGNC Primary source HGNC:HGNC:25500 See related Ensembl:ENSG00000172123 MIM:614955; AllianceGenome:HGNC:25500 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLFN3 Summary Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 3.5), urinary bladder (RPKM 3.0) and 24 other tissues See more Orthologs all
SLFN13, Official Symbol SLFN13provided by HGNC Official Full Name schlafen family member 13provided by HGNC Primary source HGNC:HGNC:26481 See related Ensembl:ENSG00000154760 MIM:614957; AllianceGenome:HGNC:26481 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLFN10; hSLFN13 Summary Enables endoribonuclease activity. Involved in rRNA catabolic process and tRNA catabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 5.2), spleen (RPKM 4.2) and 24 other tissues See more Orthologs all
SLFN14, Official Symbol SLFN14provided by HGNC Official Full Name schlafen family member 14provided by HGNC Primary source HGNC:HGNC:32689 See related Ensembl:ENSG00000236320 MIM:614958; AllianceGenome:HGNC:32689 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDPLT20 Summary The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016] Expression Biased expression in bone marrow (RPKM 1.6), spleen (RPKM 0.3) and 6 other tissues See more Orthologs mouse all
SLFN5, Official Symbol SLFN5provided by HGNC Official Full Name schlafen family member 5provided by HGNC Primary source HGNC:HGNC:28286 See related Ensembl:ENSG00000166750 MIM:614952; AllianceGenome:HGNC:28286 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 15.8), urinary bladder (RPKM 14.2) and 24 other tissues See more Orthologs all
SLFNL1, Official Symbol SLFNL1provided by HGNC Official Full Name schlafen like 1provided by HGNC Primary source HGNC:HGNC:26313 See related Ensembl:ENSG00000171790 AllianceGenome:HGNC:26313 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ATP binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 12.5) and lung (RPKM 0.6) See more Orthologs mouse all
SLFNL1-AS1, Official Symbol SLFNL1-AS1provided by HGNC Official Full Name SLFNL1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44126 See related Ensembl:ENSG00000281207 AllianceGenome:HGNC:44126 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 6.8), salivary gland (RPKM 0.9) and 14 other tissues See more
SLIRP, Official Symbol SLIRPprovided by HGNC Official Full Name SRA stem-loop interacting RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:20495 See related Ensembl:ENSG00000119705 MIM:610211; AllianceGenome:HGNC:20495 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DC50; PD04872; C14orf156 Summary Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in colon (RPKM 31.5), kidney (RPKM 28.3) and 25 other tissues See more Orthologs mouse all
SLIRPP2, Official Symbol SLIRPP2provided by HGNC Official Full Name SLIRP. pseudogene 2provided by HGNC Primary source HGNC:HGNC:55150 See related Ensembl:ENSG00000249277 AllianceGenome:HGNC:55150 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SLIT1, Official Symbol SLIT1provided by HGNC Official Full Name slit guidance ligand 1provided by HGNC Primary source HGNC:HGNC:11085 See related Ensembl:ENSG00000187122 MIM:603742; AllianceGenome:HGNC:11085 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEGF4; SLIL1; SLIT3; SLIT-1 Summary Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 15.8) and thyroid (RPKM 1.3) See more Orthologs mouse all
SLIT1-AS1, Official Symbol SLIT1-AS1provided by HGNC Official Full Name SLIT1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51198 See related Ensembl:ENSG00000234855 AllianceGenome:HGNC:51198 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 10.0) See more
SLIT2, Official Symbol SLIT2provided by HGNC Official Full Name slit guidance ligand 2provided by HGNC Primary source HGNC:HGNC:11086 See related Ensembl:ENSG00000145147 MIM:603746; AllianceGenome:HGNC:11086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLIL3; Slit-2 Summary This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Broad expression in lung (RPKM 13.1), adrenal (RPKM 9.9) and 21 other tissues See more Orthologs mouse all
SLIT2-IT1, Official Symbol SLIT2-IT1provided by HGNC Official Full Name SLIT2 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41383 See related Ensembl:ENSG00000248228 AllianceGenome:HGNC:41383 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 10.1) See more
SLIT3, Official Symbol SLIT3provided by HGNC Official Full Name slit guidance ligand 3provided by HGNC Primary source HGNC:HGNC:11087 See related Ensembl:ENSG00000184347 MIM:603745; AllianceGenome:HGNC:11087 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEGF5; SLIL2; SLIT1; slit2; Slit-3 Summary The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] Expression Broad expression in fat (RPKM 23.0), gall bladder (RPKM 21.4) and 22 other tissues See more Orthologs mouse all
SLITRK1, Official Symbol SLITRK1provided by HGNC Official Full Name SLIT and NTRK like family member 1provided by HGNC Primary source HGNC:HGNC:20297 See related Ensembl:ENSG00000178235 MIM:609678; AllianceGenome:HGNC:20297 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTM; LRRC12 Summary This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Restricted expression toward brain (RPKM 10.6) See more Orthologs mouse all
SLITRK2, Official Symbol SLITRK2provided by HGNC Official Full Name SLIT and NTRK like family member 2provided by HGNC Primary source HGNC:HGNC:13449 See related Ensembl:ENSG00000185985 MIM:300561; AllianceGenome:HGNC:13449 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXorf1; CXorf2; SLITL1; TMEM257; XLID111 Summary This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010] Expression Biased expression in brain (RPKM 6.9), spleen (RPKM 1.8) and 2 other tissues See more Orthologs mouse all
SLITRK3, Official Symbol SLITRK3provided by HGNC Official Full Name SLIT and NTRK like family member 3provided by HGNC Primary source HGNC:HGNC:23501 See related Ensembl:ENSG00000121871 MIM:609679; AllianceGenome:HGNC:23501 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the Slitrk family of structurally related transmembrane proteins that are involved in controlling neurite outgrowth. The encoded protein contains two leucine-rich repeat (LRR) domains and a C-terminal domain that is partially similar to Trk neurotrophin receptor protein. Enhanced expression of this gene was found in tissue from several different types of tumors. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Jan 2016] Expression Biased expression in brain (RPKM 6.5), esophagus (RPKM 2.6) and 6 other tissues See more Orthologs mouse all
SLITRK4, Official Symbol SLITRK4provided by HGNC Official Full Name SLIT and NTRK like family member 4provided by HGNC Primary source HGNC:HGNC:23502 See related Ensembl:ENSG00000179542 MIM:300562; AllianceGenome:HGNC:23502 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Biased expression in adrenal (RPKM 4.6), brain (RPKM 4.3) and 9 other tissues See more Orthologs mouse all
SLITRK5, Official Symbol SLITRK5provided by HGNC Official Full Name SLIT and NTRK like family member 5provided by HGNC Primary source HGNC:HGNC:20295 See related Ensembl:ENSG00000165300 MIM:609680; AllianceGenome:HGNC:20295 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC11; bA364G4.2 Summary Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008] Expression Biased expression in brain (RPKM 5.9), thyroid (RPKM 2.1) and 4 other tissues See more Orthologs mouse all
SLITRK6, Official Symbol SLITRK6provided by HGNC Official Full Name SLIT and NTRK like family member 6provided by HGNC Primary source HGNC:HGNC:23503 See related Ensembl:ENSG00000184564 MIM:609681; AllianceGenome:HGNC:23503 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNMYP Summary This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014] Expression Biased expression in urinary bladder (RPKM 12.2), salivary gland (RPKM 7.4) and 11 other tissues See more Orthologs mouse all
SLK, Official Symbol SLKprovided by HGNC Official Full Name STE20 like kinaseprovided by HGNC Primary source HGNC:HGNC:11088 See related Ensembl:ENSG00000065613 MIM:616563; AllianceGenome:HGNC:11088 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOSK; STK2; se20-9; bA16H23.1 Summary Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 35.4), lung (RPKM 15.9) and 25 other tissues See more Orthologs mouse all
SLMAP, Official Symbol SLMAPprovided by HGNC Official Full Name sarcolemma associated proteinprovided by HGNC Primary source HGNC:HGNC:16643 See related Ensembl:ENSG00000163681 MIM:602701; AllianceGenome:HGNC:16643 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLAP Summary This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] Expression Ubiquitous expression in heart (RPKM 29.5), esophagus (RPKM 29.0) and 24 other tissues See more Orthologs mouse all
SLN, Official Symbol SLNprovided by HGNC Official Full Name sarcolipinprovided by HGNC Primary source HGNC:HGNC:11089 See related Ensembl:ENSG00000170290 MIM:602203; AllianceGenome:HGNC:11089 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 82.3), esophagus (RPKM 53.1) and 2 other tissues See more Orthologs mouse all