psui3905/ncbi_genes_summary huggingface dataset:
PLIN5, Official Symbol PLIN5provided by HGNC Official Full Name perilipin 5provided by HGNC Primary source HGNC:HGNC:33196 See related Ensembl:ENSG00000214456 MIM:613248; AllianceGenome:HGNC:33196 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLDP; LSDA5; LSDP5; OXPAT Summary Predicted to enable identical protein binding activity and lipase binding activity. Predicted to be involved in several processes, including negative regulation of peroxisome proliferator activated receptor signaling pathway; regulation of lipase activity; and regulation of lipid metabolic process. Located in intracellular membrane-bounded organelle and lipid droplet. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 26.3), ovary (RPKM 14.4) and 10 other tissues See more Orthologs mouse all
PLK1, Official Symbol PLK1provided by HGNC Official Full Name polo like kinase 1provided by HGNC Primary source HGNC:HGNC:9077 See related Ensembl:ENSG00000166851 MIM:602098; AllianceGenome:HGNC:9077 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLK; STPK13 Summary The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015] Expression Biased expression in testis (RPKM 20.5), lymph node (RPKM 15.8) and 13 other tissues See more Orthologs mouse all
PLK2, Official Symbol PLK2provided by HGNC Official Full Name polo like kinase 2provided by HGNC Primary source HGNC:HGNC:19699 See related Ensembl:ENSG00000145632 MIM:607023; AllianceGenome:HGNC:19699 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SNK; hSNK; hPlk2 Summary The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Expression Broad expression in spleen (RPKM 41.3), placenta (RPKM 28.6) and 25 other tissues See more Orthologs mouse all
PLK3, Official Symbol PLK3provided by HGNC Official Full Name polo like kinase 3provided by HGNC Primary source HGNC:HGNC:2154 See related Ensembl:ENSG00000173846 MIM:602913; AllianceGenome:HGNC:2154 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNK; FNK; PRK; PLK-3 Summary The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in bone marrow (RPKM 16.1), gall bladder (RPKM 12.7) and 25 other tissues See more Orthologs mouse all
PLK4, Official Symbol PLK4provided by HGNC Official Full Name polo like kinase 4provided by HGNC Primary source HGNC:HGNC:11397 See related Ensembl:ENSG00000142731 MIM:605031; AllianceGenome:HGNC:11397 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAK; STK18; MCCRP2 Summary This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Expression Biased expression in testis (RPKM 12.2), bone marrow (RPKM 8.2) and 12 other tissues See more Orthologs mouse all
PLK5, Official Symbol PLK5provided by HGNC Official Full Name polo like kinase 5 (inactive)provided by HGNC Primary source HGNC:HGNC:27001 See related Ensembl:ENSG00000185988 AllianceGenome:HGNC:27001 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLK-5; PLK5P; SgK384ps Summary Predicted to enable ATP binding activity and protein kinase activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 2.5), endometrium (RPKM 1.6) and 3 other tissues See more Orthologs mouse all
PLLP, Official Symbol PLLPprovided by HGNC Official Full Name plasmolipinprovided by HGNC Primary source HGNC:HGNC:18553 See related Ensembl:ENSG00000102934 MIM:600340; AllianceGenome:HGNC:18553 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PMLP; TM4SF11 Summary Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in compact myelin and membrane raft. Predicted to be integral component of membrane. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 41.3), stomach (RPKM 28.7) and 17 other tissues See more Orthologs mouse all
PLN, Official Symbol PLNprovided by HGNC Official Full Name phospholambanprovided by HGNC Primary source HGNC:HGNC:9080 See related Ensembl:ENSG00000198523 MIM:172405; AllianceGenome:HGNC:9080 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLB; CMD1P; CMH18 Summary The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016] Expression Biased expression in heart (RPKM 615.2), gall bladder (RPKM 62.5) and 1 other tissue See more Orthologs mouse all
PLOD1, Official Symbol PLOD1provided by HGNC Official Full Name procollagen-lysine,2-oxoglutarate 5-dioxygenase 1provided by HGNC Primary source HGNC:HGNC:9081 See related Ensembl:ENSG00000083444 MIM:153454; AllianceGenome:HGNC:9081 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LH; LH1; LLH; EDS6; PLOD; EDSKCL1 Summary Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in placenta (RPKM 47.0), endometrium (RPKM 37.3) and 25 other tissues See more Orthologs mouse all
PLOD2, Official Symbol PLOD2provided by HGNC Official Full Name procollagen-lysine,2-oxoglutarate 5-dioxygenase 2provided by HGNC Primary source HGNC:HGNC:9082 See related Ensembl:ENSG00000152952 MIM:601865; AllianceGenome:HGNC:9082 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LH2; TLH; BRKS2 Summary The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 48.4), fat (RPKM 35.4) and 19 other tissues See more Orthologs mouse all
PLOD3, Official Symbol PLOD3provided by HGNC Official Full Name procollagen-lysine,2-oxoglutarate 5-dioxygenase 3provided by HGNC Primary source HGNC:HGNC:9083 See related Ensembl:ENSG00000106397 MIM:603066; AllianceGenome:HGNC:9083 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LH3 Summary The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 21.7), endometrium (RPKM 12.9) and 25 other tissues See more Orthologs mouse all
PLP1, Official Symbol PLP1provided by HGNC Official Full Name proteolipid protein 1provided by HGNC Primary source HGNC:HGNC:9086 See related Ensembl:ENSG00000123560 MIM:300401; AllianceGenome:HGNC:9086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20 Summary This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015] Expression Restricted expression toward brain (RPKM 1259.3) See more Orthologs mouse all
PLP2, Official Symbol PLP2provided by HGNC Official Full Name proteolipid protein 2provided by HGNC Primary source HGNC:HGNC:9087 See related Ensembl:ENSG00000102007 MIM:300112; AllianceGenome:HGNC:9087 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A4; A4LSB Summary This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010] Expression Ubiquitous expression in skin (RPKM 154.7), esophagus (RPKM 126.0) and 23 other tissues See more Orthologs mouse all
PLPBP, Official Symbol PLPBPprovided by HGNC Official Full Name pyridoxal phosphate binding proteinprovided by HGNC Primary source HGNC:HGNC:9457 See related Ensembl:ENSG00000147471 MIM:604436; AllianceGenome:HGNC:9457 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPEO1; PROSC; EPVB6D Summary This gene encodes a pyridoxal 5'-phosphate binding protein involved in the homeostatic regulation of intracellular pyridoxal 5'-phosphate. This gene has a tumor suppressive effect on hepatocellular carcinoma and other solid tumors of epithelial origin. Naturally occurring mutations in this gene are associated with a pyridoxine-dependent epilepsy. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in kidney (RPKM 12.8), colon (RPKM 10.6) and 25 other tissues See more Orthologs mouse all
PLPP1, Official Symbol PLPP1provided by HGNC Official Full Name phospholipid phosphatase 1provided by HGNC Primary source HGNC:HGNC:9228 See related Ensembl:ENSG00000067113 MIM:607124; AllianceGenome:HGNC:9228 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPP1; PAP2; LLP1a; PAP-2a; PPAP2A Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] Expression Broad expression in prostate (RPKM 96.2), gall bladder (RPKM 74.3) and 22 other tissues See more Orthologs mouse all
PLPP2, Official Symbol PLPP2provided by HGNC Official Full Name phospholipid phosphatase 2provided by HGNC Primary source HGNC:HGNC:9230 See related Ensembl:ENSG00000141934 MIM:607126; AllianceGenome:HGNC:9230 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPP2; PAP-2c; PAP2-g; PPAP2C Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 23.7), duodenum (RPKM 23.0) and 17 other tissues See more Orthologs mouse all
PLPP3, Official Symbol PLPP3provided by HGNC Official Full Name phospholipid phosphatase 3provided by HGNC Primary source HGNC:HGNC:9229 See related Ensembl:ENSG00000162407 MIM:607125; AllianceGenome:HGNC:9229 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPP3; VCIP; Dri42; PAP2B; PPAP2B Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010] Expression Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues See more Orthologs mouse all
PLPP4, Official Symbol PLPP4provided by HGNC Official Full Name phospholipid phosphatase 4provided by HGNC Primary source HGNC:HGNC:23531 See related Ensembl:ENSG00000203805 AllianceGenome:HGNC:23531 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPPL2; PPAPDC1; PPAPDC1A Summary Enables diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
PLPP5, Official Symbol PLPP5provided by HGNC Official Full Name phospholipid phosphatase 5provided by HGNC Primary source HGNC:HGNC:25026 See related Ensembl:ENSG00000147535 MIM:610626; AllianceGenome:HGNC:25026 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DPPL1; HTPAP; PPAPDC1B Summary Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 24.6), duodenum (RPKM 12.1) and 25 other tissues See more Orthologs mouse all
PLPP6, Official Symbol PLPP6provided by HGNC Official Full Name phospholipid phosphatase 6provided by HGNC Primary source HGNC:HGNC:23682 See related Ensembl:ENSG00000205808 MIM:611666; AllianceGenome:HGNC:23682 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDP1; PSDP; LPRP-B; PA-PSP; PPAPDC2; bA6J24.6 Summary Enables lipid phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
PLPP7, Official Symbol PLPP7provided by HGNC Official Full Name phospholipid phosphatase 7 (inactive)provided by HGNC Primary source HGNC:HGNC:28174 See related Ensembl:ENSG00000160539 MIM:618743; AllianceGenome:HGNC:28174 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NET39; C9orf67; PPAPDC3 Summary Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to act upstream of or within negative regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in membrane and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in heart (RPKM 14.9), brain (RPKM 2.9) and 9 other tissues See more Orthologs mouse all
PLPPR1, Official Symbol PLPPR1provided by HGNC Official Full Name phospholipid phosphatase related 1provided by HGNC Primary source HGNC:HGNC:25993 See related Ensembl:ENSG00000148123 MIM:619590; AllianceGenome:HGNC:25993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRG3; LPPR1; PRG-3 Summary This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 18.9), kidney (RPKM 12.9) and 2 other tissues See more Orthologs mouse all
PLPPR2, Official Symbol PLPPR2provided by HGNC Official Full Name phospholipid phosphatase related 2provided by HGNC Primary source HGNC:HGNC:29566 See related Ensembl:ENSG00000105520 MIM:619591; AllianceGenome:HGNC:29566 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRG4; LPPR2 Summary Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 26.0), prostate (RPKM 12.8) and 25 other tissues See more Orthologs mouse all
PLPPR3, Official Symbol PLPPR3provided by HGNC Official Full Name phospholipid phosphatase related 3provided by HGNC Primary source HGNC:HGNC:23497 See related Ensembl:ENSG00000129951 MIM:610391; AllianceGenome:HGNC:23497 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPR3; PRG2; LPPR3; PRG-2 Summary The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008] Expression Biased expression in bone marrow (RPKM 2.7), brain (RPKM 2.5) and 2 other tissues See more Orthologs mouse all
PLPPR4, Official Symbol PLPPR4provided by HGNC Official Full Name phospholipid phosphatase related 4provided by HGNC Primary source HGNC:HGNC:23496 See related Ensembl:ENSG00000117600 MIM:607813; AllianceGenome:HGNC:23496 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPR4; PHP1; PRG1; LPPR4; PRG-1 Summary The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Expression Biased expression in brain (RPKM 35.4), testis (RPKM 3.7) and 2 other tissues See more Orthologs mouse all
PLPPR5, Official Symbol PLPPR5provided by HGNC Official Full Name phospholipid phosphatase related 5provided by HGNC Primary source HGNC:HGNC:31703 See related Ensembl:ENSG00000117598 MIM:617287; AllianceGenome:HGNC:31703 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAP2; PRG5; LPPR5; PAP2D Summary The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 3.8), testis (RPKM 1.2) and 1 other tissue See more Orthologs mouse all
PLRG1, Official Symbol PLRG1provided by HGNC Official Full Name pleiotropic regulator 1provided by HGNC Primary source HGNC:HGNC:9089 See related Ensembl:ENSG00000171566 MIM:605961; AllianceGenome:HGNC:9089 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cwc1; PRL1; PRP46; PRPF46; TANGO4 Summary This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 13.3) and 25 other tissues See more Orthologs mouse all
PLS1, Official Symbol PLS1provided by HGNC Official Full Name plastin 1provided by HGNC Primary source HGNC:HGNC:9090 See related Ensembl:ENSG00000120756 MIM:602734; AllianceGenome:HGNC:9090 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNA76 Summary Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010] Expression Biased expression in small intestine (RPKM 111.8), duodenum (RPKM 68.2) and 5 other tissues See more Orthologs mouse all
PLS1-AS1, Official Symbol PLS1-AS1provided by HGNC Official Full Name PLS1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40451 See related AllianceGenome:HGNC:40451 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PLS3, Official Symbol PLS3provided by HGNC Official Full Name plastin 3provided by HGNC Primary source HGNC:HGNC:9091 See related Ensembl:ENSG00000102024 MIM:300131; AllianceGenome:HGNC:9091 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BMND18; T-plastin Summary Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] Expression Ubiquitous expression in thyroid (RPKM 88.8), lung (RPKM 70.6) and 23 other tissues See more Orthologs mouse all
PLS3-AS1, Official Symbol PLS3-AS1provided by HGNC Official Full Name PLS3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50343 See related Ensembl:ENSG00000271826 AllianceGenome:HGNC:50343 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PLSCR1, Official Symbol PLSCR1provided by HGNC Official Full Name phospholipid scramblase 1provided by HGNC Primary source HGNC:HGNC:9092 See related Ensembl:ENSG00000188313 MIM:604170; AllianceGenome:HGNC:9092 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMTRA1B Summary This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses. [provided by RefSeq, May 2022] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in appendix (RPKM 43.5), gall bladder (RPKM 33.7) and 25 other tissues See more Orthologs all
PLSCR2, Official Symbol PLSCR2provided by HGNC Official Full Name phospholipid scramblase 2provided by HGNC Primary source HGNC:HGNC:16494 See related Ensembl:ENSG00000163746 MIM:607610; AllianceGenome:HGNC:16494 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
PLSCR3, Official Symbol PLSCR3provided by HGNC Official Full Name phospholipid scramblase 3provided by HGNC Primary source HGNC:HGNC:16495 See related Ensembl:ENSG00000187838 MIM:607611; AllianceGenome:HGNC:16495 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables several functions, including calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in several processes, including cardiolipin biosynthetic process; regulation of apoptotic process; and regulation of release of cytochrome c from mitochondria. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 12.9), fat (RPKM 12.1) and 25 other tissues See more Orthologs mouse all
PLSCR4, Official Symbol PLSCR4provided by HGNC Official Full Name phospholipid scramblase 4provided by HGNC Primary source HGNC:HGNC:16497 See related Ensembl:ENSG00000114698 MIM:607612; AllianceGenome:HGNC:16497 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRA1 Summary Enables CD4 receptor binding activity and enzyme binding activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to act upstream of or within cellular response to lipopolysaccharide. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 22.0), gall bladder (RPKM 21.1) and 24 other tissues See more Orthologs mouse all
PLSCR5, Official Symbol PLSCR5provided by HGNC Official Full Name phospholipid scramblase family member 5provided by HGNC Primary source HGNC:HGNC:19952 See related Ensembl:ENSG00000231213 AllianceGenome:HGNC:19952 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
PLTP, Official Symbol PLTPprovided by HGNC Official Full Name phospholipid transfer proteinprovided by HGNC Primary source HGNC:HGNC:9093 See related Ensembl:ENSG00000100979 MIM:172425; AllianceGenome:HGNC:9093 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPIFE; HDLCQ9 Summary The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 205.6), gall bladder (RPKM 89.3) and 21 other tissues See more Orthologs mouse all
PLUT, Official Symbol PLUTprovided by HGNC Official Full Name PDX1 associated lncRNA, upregulator of transcriptionprovided by HGNC Primary source HGNC:HGNC:43698 See related AllianceGenome:HGNC:43698 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLUTO; HI-LNC71; PDX1-AS1 Expression Low expression observed in reference dataset See more
PLVAP, Official Symbol PLVAPprovided by HGNC Official Full Name plasmalemma vesicle associated proteinprovided by HGNC Primary source HGNC:HGNC:13635 See related Ensembl:ENSG00000130300 MIM:607647; AllianceGenome:HGNC:13635 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PV1; FELS; PV-1; gp68; DIAR10 Summary Predicted to enable identical protein binding activity. Involved in MAPK cascade; positive regulation of cellular extravasation; and tumor necrosis factor-mediated signaling pathway. Located in cell surface. Colocalizes with caveola. Implicated in congenital diarrhea. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in thyroid (RPKM 131.8), spleen (RPKM 92.7) and 20 other tissues See more Orthologs mouse all
PLXDC1, Official Symbol PLXDC1provided by HGNC Official Full Name plexin domain containing 1provided by HGNC Primary source HGNC:HGNC:20945 See related Ensembl:ENSG00000161381 MIM:606826; AllianceGenome:HGNC:20945 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEM3; TEM7 Summary Predicted to be involved in angiogenesis and spinal cord development. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 7.4), endometrium (RPKM 6.4) and 23 other tissues See more Orthologs mouse all
PLXDC2, Official Symbol PLXDC2provided by HGNC Official Full Name plexin domain containing 2provided by HGNC Primary source HGNC:HGNC:21013 See related Ensembl:ENSG00000120594 MIM:606827; AllianceGenome:HGNC:21013 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEM7R; PLXDC2-OT Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 10.7), lung (RPKM 7.5) and 24 other tissues See more Orthologs mouse all
PLXNA1, Official Symbol PLXNA1provided by HGNC Official Full Name plexin A1provided by HGNC Primary source HGNC:HGNC:9099 See related Ensembl:ENSG00000114554 MIM:601055; AllianceGenome:HGNC:9099 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOV; NOVP; PLXN1; DWOPNED; PLEXIN-A1 Summary Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including generation of neurons; regulation of GTPase activity; and regulation of cell shape. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lung (RPKM 7.9), testis (RPKM 6.7) and 24 other tissues See more Orthologs mouse all
PLXNA2, Official Symbol PLXNA2provided by HGNC Official Full Name plexin A2provided by HGNC Primary source HGNC:HGNC:9100 See related Ensembl:ENSG00000076356 MIM:601054; AllianceGenome:HGNC:9100 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OCT; PLXN2 Summary This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 8.4), lung (RPKM 6.9) and 23 other tissues See more Orthologs mouse all
PLXNA3, Official Symbol PLXNA3provided by HGNC Official Full Name plexin A3provided by HGNC Primary source HGNC:HGNC:9101 See related Ensembl:ENSG00000130827 MIM:300022; AllianceGenome:HGNC:9101 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE Summary This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in skin (RPKM 7.2), ovary (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
PLXNA4, Official Symbol PLXNA4provided by HGNC Official Full Name plexin A4provided by HGNC Primary source HGNC:HGNC:9102 See related Ensembl:ENSG00000221866 MIM:604280; AllianceGenome:HGNC:9102 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLEXA4; PLXNA4A; PLXNA4B; FAYV2820; PRO34003 Summary Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including axon guidance; positive regulation of axonogenesis; and regulation of GTPase activity. Predicted to act upstream of or within several processes, including nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 7.3), brain (RPKM 3.4) and 14 other tissues See more Orthologs mouse all
PLXNB1, Official Symbol PLXNB1provided by HGNC Official Full Name plexin B1provided by HGNC Primary source HGNC:HGNC:9103 See related Ensembl:ENSG00000164050 MIM:601053; AllianceGenome:HGNC:9103 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEP; PLXN5; PLEXIN-B1 Summary Enables semaphorin receptor activity. Involved in several processes, including negative regulation of cell adhesion; regulation of cell shape; and semaphorin-plexin signaling pathway. Is integral component of plasma membrane. Part of semaphorin receptor complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 13.8), kidney (RPKM 13.0) and 24 other tissues See more Orthologs mouse all
PLXNB2, Official Symbol PLXNB2provided by HGNC Official Full Name plexin B2provided by HGNC Primary source HGNC:HGNC:9104 See related Ensembl:ENSG00000196576 MIM:604293; AllianceGenome:HGNC:9104 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MM1; PLEXB2; lncFAL; Nbla00445; dJ402G11.3 Summary Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues See more Orthologs mouse all
PLXNB3, Official Symbol PLXNB3provided by HGNC Official Full Name plexin B3provided by HGNC Primary source HGNC:HGNC:9105 See related Ensembl:ENSG00000198753 MIM:300214; AllianceGenome:HGNC:9105 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLEXR; PLXN6; PLEXB3 Summary The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Broad expression in brain (RPKM 10.9), salivary gland (RPKM 4.4) and 16 other tissues See more Orthologs mouse all