psui3905/ncbi_genes_summary huggingface dataset:
XRN1, Official Symbol XRN1provided by HGNC Official Full Name 5'-3' exoribonuclease 1provided by HGNC Primary source HGNC:HGNC:30654 See related Ensembl:ENSG00000114127 MIM:607994; AllianceGenome:HGNC:30654 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEP1 Summary This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in appendix (RPKM 6.9), lymph node (RPKM 6.5) and 25 other tissues See more Orthologs mouse all
XRN2, Official Symbol XRN2provided by HGNC Official Full Name 5'-3' exoribonuclease 2provided by HGNC Primary source HGNC:HGNC:12836 See related Ensembl:ENSG00000088930 MIM:608851; AllianceGenome:HGNC:12836 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in appendix (RPKM 21.1), thyroid (RPKM 20.8) and 25 other tissues See more Orthologs mouse all
XRRA1, Official Symbol XRRA1provided by HGNC Official Full Name X-ray radiation resistance associated 1provided by HGNC Primary source HGNC:HGNC:18868 See related Ensembl:ENSG00000166435 MIM:609788; AllianceGenome:HGNC:18868 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in response to X-ray. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 10.6), thyroid (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
XXYLT1, Official Symbol XXYLT1provided by HGNC Official Full Name xyloside xylosyltransferase 1provided by HGNC Primary source HGNC:HGNC:26639 See related Ensembl:ENSG00000173950 MIM:614552; AllianceGenome:HGNC:26639 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3orf21 Summary Enables magnesium ion binding activity; manganese ion binding activity; and xylosyl alpha-1,3-xylosyltransferase activity. Involved in O-glycan processing. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 1.4), esophagus (RPKM 1.2) and 24 other tissues See more Orthologs mouse all
XXYLT1-AS1, Official Symbol XXYLT1-AS1provided by HGNC Official Full Name XXYLT1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41153 See related Ensembl:ENSG00000233303 AllianceGenome:HGNC:41153 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
XYLB, Official Symbol XYLBprovided by HGNC Official Full Name xylulokinaseprovided by HGNC Primary source HGNC:HGNC:12839 See related Ensembl:ENSG00000093217 MIM:604049; AllianceGenome:HGNC:12839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009] Expression Broad expression in liver (RPKM 5.0), kidney (RPKM 3.6) and 18 other tissues See more Orthologs mouse all
XYLT1, Official Symbol XYLT1provided by HGNC Official Full Name xylosyltransferase 1provided by HGNC Primary source HGNC:HGNC:15516 See related Ensembl:ENSG00000103489 MIM:608124; AllianceGenome:HGNC:15516 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XT1; XTI; XT-I; DBQD2; XYLTI; PXYLT1; xylT-I Summary This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009] Expression Ubiquitous expression in brain (RPKM 5.2), placenta (RPKM 4.3) and 24 other tissues See more Orthologs mouse all
XYLT2, Official Symbol XYLT2provided by HGNC Official Full Name xylosyltransferase 2provided by HGNC Primary source HGNC:HGNC:15517 See related Ensembl:ENSG00000015532 MIM:608125; AllianceGenome:HGNC:15517 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SOS; XT2; XT-II; PXYLT2; xylT-II Summary The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] Expression Ubiquitous expression in stomach (RPKM 12.9), testis (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
YAE1, Official Symbol YAE1provided by HGNC Official Full Name YAE1 maturation factor of ABCE1provided by HGNC Primary source HGNC:HGNC:24857 See related Ensembl:ENSG00000241127 AllianceGenome:HGNC:24857 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CIAB2; GK003; YAE1D1; C7orf36 Summary Involved in protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 3.0), endometrium (RPKM 2.4) and 25 other tissues See more Orthologs mouse all
YAF2, Official Symbol YAF2provided by HGNC Official Full Name YY1 associated factor 2provided by HGNC Primary source HGNC:HGNC:17363 See related Ensembl:ENSG00000015153 MIM:607534; AllianceGenome:HGNC:17363 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in heart (RPKM 3.8), brain (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
YAP1, Official Symbol YAP1provided by HGNC Official Full Name Yes1 associated transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:16262 See related Ensembl:ENSG00000137693 MIM:606608; AllianceGenome:HGNC:16262 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YAP; YKI; COB1; YAP2; YAP-1; YAP65 Summary This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in thyroid (RPKM 45.0), endometrium (RPKM 38.7) and 23 other tissues See more Orthologs mouse all
YAP1P1, Official Symbol YAP1P1provided by HGNC Official Full Name YAP1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:38016 See related Ensembl:ENSG00000220494 AllianceGenome:HGNC:38016 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YARS1, Official Symbol YARS1provided by HGNC Official Full Name tyrosyl-tRNA synthetase 1provided by HGNC Primary source HGNC:HGNC:12840 See related Ensembl:ENSG00000134684 MIM:603623; AllianceGenome:HGNC:12840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YRS; YTS; YARS; TYRRS; CMTDIC; IMNEPD2 Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 25.7), brain (RPKM 24.4) and 25 other tissues See more Orthologs mouse all
YARS2, Official Symbol YARS2provided by HGNC Official Full Name tyrosyl-tRNA synthetase 2provided by HGNC Primary source HGNC:HGNC:24249 See related Ensembl:ENSG00000139131 MIM:610957; AllianceGenome:HGNC:24249 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TYRRS; CGI-04; MLASA2; MT-TYRRS Summary This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in brain (RPKM 10.0), endometrium (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
YBEY, Official Symbol YBEYprovided by HGNC Official Full Name ybeY metalloendoribonucleaseprovided by HGNC Primary source HGNC:HGNC:1299 See related Ensembl:ENSG00000182362 MIM:617461; AllianceGenome:HGNC:1299 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C21orf57 Summary This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Broad expression in testis (RPKM 8.0), thyroid (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
YBX1, Official Symbol YBX1provided by HGNC Official Full Name Y-box binding protein 1provided by HGNC Primary source HGNC:HGNC:8014 See related Ensembl:ENSG00000065978 MIM:154030; AllianceGenome:HGNC:8014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1 Summary This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in testis (RPKM 220.6), fat (RPKM 121.2) and 25 other tissues See more Orthologs mouse all
YBX1P2, Official Symbol YBX1P2provided by HGNC Official Full Name Y-box binding protein 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:22635 See related AllianceGenome:HGNC:22635 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YBX1P3, Official Symbol YBX1P3provided by HGNC Official Full Name Y-box binding protein 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:42424 See related AllianceGenome:HGNC:42424 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YBX1P4, Official Symbol YBX1P4provided by HGNC Official Full Name Y-box binding protein 1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:42425 See related Ensembl:ENSG00000213188 AllianceGenome:HGNC:42425 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YBX1P8, Official Symbol YBX1P8provided by HGNC Official Full Name Y-box binding protein 1 pseudogene 8provided by HGNC Primary source HGNC:HGNC:42429 See related AllianceGenome:HGNC:42429 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YBX1P9, Official Symbol YBX1P9provided by HGNC Official Full Name Y-box binding protein 1 pseudogene 9provided by HGNC Primary source HGNC:HGNC:42430 See related Ensembl:ENSG00000236994 AllianceGenome:HGNC:42430 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YBX2, Official Symbol YBX2provided by HGNC Official Full Name Y-box binding protein 2provided by HGNC Primary source HGNC:HGNC:17948 See related Ensembl:ENSG00000006047 MIM:611447; AllianceGenome:HGNC:17948 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBPC; MSY2; CSDA3; CONTRIN Summary This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012] Expression Restricted expression toward testis (RPKM 189.1) See more Orthologs mouse all
YBX3, Official Symbol YBX3provided by HGNC Official Full Name Y-box binding protein 3provided by HGNC Primary source HGNC:HGNC:2428 See related Ensembl:ENSG00000060138 MIM:603437; AllianceGenome:HGNC:2428 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSDA; DBPA; CSDA1; ZONAB Summary Enables RNA binding activity. Involved in cellular hyperosmotic response; cellular response to tumor necrosis factor; and negative regulation of programmed cell death. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 175.4), skin (RPKM 131.9) and 23 other tissues See more Orthologs mouse all
YDJC, Official Symbol YDJCprovided by HGNC Official Full Name YdjC chitooligosaccharide deacetylase homologprovided by HGNC Primary source HGNC:HGNC:27158 See related Ensembl:ENSG00000161179 MIM:619770; AllianceGenome:HGNC:27158 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable deacetylase activity and magnesium ion binding activity. Predicted to be involved in carbohydrate metabolic process. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 4.9), colon (RPKM 4.2) and 25 other tissues See more Orthologs mouse all
YEATS2, Official Symbol YEATS2provided by HGNC Official Full Name YEATS domain containing 2provided by HGNC Primary source HGNC:HGNC:25489 See related Ensembl:ENSG00000163872 MIM:613373; AllianceGenome:HGNC:25489 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAME4 Summary Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017] Expression Ubiquitous expression in ovary (RPKM 7.4), brain (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
YEATS4, Official Symbol YEATS4provided by HGNC Official Full Name YEATS domain containing 4provided by HGNC Primary source HGNC:HGNC:24859 See related Ensembl:ENSG00000127337 MIM:602116; AllianceGenome:HGNC:24859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik Summary The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] Expression Broad expression in testis (RPKM 7.3), bone marrow (RPKM 4.6) and 25 other tissues See more Orthologs mouse all
YES1, Official Symbol YES1provided by HGNC Official Full Name YES proto-oncogene 1, Src family tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:12841 See related Ensembl:ENSG00000176105 MIM:164880; AllianceGenome:HGNC:12841 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Yes; c-yes; HsT441; P61-YES Summary This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues See more Orthologs mouse all
YIF1A, Official Symbol YIF1Aprovided by HGNC Official Full Name Yip1 interacting factor homolog A, membrane trafficking proteinprovided by HGNC Primary source HGNC:HGNC:16688 See related Ensembl:ENSG00000174851 MIM:611484; AllianceGenome:HGNC:16688 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 54TM; YIF1; YIF1P; FinGER7 Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 11.2), liver (RPKM 9.6) and 25 other tissues See more Orthologs mouse all
YIF1B, Official Symbol YIF1Bprovided by HGNC Official Full Name Yip1 interacting factor homolog B, membrane trafficking proteinprovided by HGNC Primary source HGNC:HGNC:30511 See related Ensembl:ENSG00000167645 MIM:619109; AllianceGenome:HGNC:30511 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FinGER8; KABAMAS Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein targeting to membrane; and sperm axoneme assembly. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 13.5), small intestine (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
YIPF1, Official Symbol YIPF1provided by HGNC Official Full Name Yip1 domain family member 1provided by HGNC Primary source HGNC:HGNC:25231 See related Ensembl:ENSG00000058799 MIM:617521; AllianceGenome:HGNC:25231 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FinGER1; DJ167A19.1 Summary Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle-mediated transport. Located in several cellular components, including Golgi apparatus subcompartment; nucleoplasm; and transport vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 28.9), prostate (RPKM 18.8) and 25 other tissues See more Orthologs mouse all
YIPF2, Official Symbol YIPF2provided by HGNC Official Full Name Yip1 domain family member 2provided by HGNC Primary source HGNC:HGNC:28476 See related Ensembl:ENSG00000130733 MIM:617522; AllianceGenome:HGNC:28476 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FinGER2 Summary Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle-mediated transport. Located in Golgi apparatus subcompartment and transport vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 22.9), placenta (RPKM 21.1) and 25 other tissues See more Orthologs mouse all
YIPF3, Official Symbol YIPF3provided by HGNC Official Full Name Yip1 domain family member 3provided by HGNC Primary source HGNC:HGNC:21023 See related Ensembl:ENSG00000137207 MIM:609775; AllianceGenome:HGNC:21023 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLIP1; FinGER3; C6orf109; dJ337H4.3 Summary Predicted to be involved in cell differentiation. Located in Golgi apparatus and transport vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 36.5), prostate (RPKM 33.2) and 25 other tissues See more Orthologs mouse all
YIPF4, Official Symbol YIPF4provided by HGNC Official Full Name Yip1 domain family member 4provided by HGNC Primary source HGNC:HGNC:28145 See related Ensembl:ENSG00000119820 MIM:617534; AllianceGenome:HGNC:28145 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FinGER4; Nbla11189 Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 14.7), fat (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
YIPF5, Official Symbol YIPF5provided by HGNC Official Full Name Yip1 domain family member 5provided by HGNC Primary source HGNC:HGNC:24877 See related Ensembl:ENSG00000145817 MIM:611483; AllianceGenome:HGNC:24877 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEDS2; SB140; SMAP5; YIP1A; SMAP-5; FinGER5 Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; regulation of ER to Golgi vesicle-mediated transport; and vesicle fusion with Golgi apparatus. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 14.2), thyroid (RPKM 12.3) and 25 other tissues See more Orthologs mouse all
YIPF6, Official Symbol YIPF6provided by HGNC Official Full Name Yip1 domain family member 6provided by HGNC Primary source HGNC:HGNC:28304 See related Ensembl:ENSG00000181704 MIM:300996; AllianceGenome:HGNC:28304 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FinGER6 Summary Predicted to enable identical protein binding activity. Predicted to act upstream of or within intestinal epithelial cell development. Located in Golgi apparatus subcompartment and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 11.2), prostate (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
YIPF7, Official Symbol YIPF7provided by HGNC Official Full Name Yip1 domain family member 7provided by HGNC Primary source HGNC:HGNC:26825 See related Ensembl:ENSG00000177752 MIM:619754; AllianceGenome:HGNC:26825 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FinGER9 Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
YJEFN3, Official Symbol YJEFN3provided by HGNC Official Full Name YjeF N-terminal domain containing 3provided by HGNC Primary source HGNC:HGNC:24785 See related Ensembl:ENSG00000250067 MIM:618607; AllianceGenome:HGNC:24785 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable NADHX epimerase activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; membrane raft distribution; and negative regulation of angiogenesis. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 3.9), brain (RPKM 3.2) and 23 other tissues See more Orthologs mouse all
YJU2, Official Symbol YJU2provided by HGNC Official Full Name YJU2 splicing factor homologprovided by HGNC Primary source HGNC:HGNC:25518 See related Ensembl:ENSG00000105248 AllianceGenome:HGNC:25518 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCDC94 Summary Predicted to enable metal ion binding activity. Predicted to be involved in RNA splicing and negative regulation of DNA damage response, signal transduction by p53 class mediator. Part of U2-type catalytic step 1 spliceosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 15.6), ovary (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
YKT6, Official Symbol YKT6provided by HGNC Official Full Name YKT6 v-SNARE homologprovided by HGNC Primary source HGNC:HGNC:16959 See related Ensembl:ENSG00000106636 MIM:606209; AllianceGenome:HGNC:16959 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 24.8), colon (RPKM 21.7) and 25 other tissues See more Orthologs mouse all
YLPM1, Official Symbol YLPM1provided by HGNC Official Full Name YLP motif containing 1provided by HGNC Primary source HGNC:HGNC:17798 See related Ensembl:ENSG00000119596 MIM:619766; AllianceGenome:HGNC:17798 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZAP3; ZAP113; PPP1R169; C14orf170 Summary Enables RNA binding activity. Predicted to be involved in regulation of telomere maintenance. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 14.0), brain (RPKM 9.5) and 25 other tissues See more Orthologs mouse all
YME1L1, Official Symbol YME1L1provided by HGNC Official Full Name YME1 like 1 ATPaseprovided by HGNC Primary source HGNC:HGNC:12843 See related Ensembl:ENSG00000136758 MIM:607472; AllianceGenome:HGNC:12843 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTSH; MEG4; PAMP; OPA11; YME1L Summary The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in thyroid (RPKM 32.8), testis (RPKM 26.7) and 25 other tissues See more Orthologs mouse all
YME1L1P1, Official Symbol YME1L1P1provided by HGNC Official Full Name YME1L1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:12844 See related Ensembl:ENSG00000236831 AllianceGenome:HGNC:12844 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YME1L2
YOD1, Official Symbol YOD1provided by HGNC Official Full Name YOD1 deubiquitinaseprovided by HGNC Primary source HGNC:HGNC:25035 See related Ensembl:ENSG00000180667 MIM:612023; AllianceGenome:HGNC:25035 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUBA8; OTUD2; PRO0907 Summary Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] Expression Broad expression in bone marrow (RPKM 24.5), esophagus (RPKM 15.7) and 23 other tissues See more Orthologs mouse all
YPEL1, Official Symbol YPEL1provided by HGNC Official Full Name yippee like 1provided by HGNC Primary source HGNC:HGNC:12845 See related Ensembl:ENSG00000100027 MIM:608082; AllianceGenome:HGNC:12845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKSG3 Summary This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. [provided by RefSeq, Feb 2015] Expression Broad expression in testis (RPKM 12.9), brain (RPKM 4.5) and 25 other tissues See more Orthologs mouse all
YPEL2, Official Symbol YPEL2provided by HGNC Official Full Name yippee like 2provided by HGNC Primary source HGNC:HGNC:18326 See related Ensembl:ENSG00000175155 MIM:609723; AllianceGenome:HGNC:18326 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKSG4 Summary Predicted to enable metal ion binding activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 5.3), bone marrow (RPKM 5.1) and 25 other tissues See more Orthologs mouse all
YPEL3, Official Symbol YPEL3provided by HGNC Official Full Name yippee like 3provided by HGNC Primary source HGNC:HGNC:18327 See related Ensembl:ENSG00000090238 MIM:609724; AllianceGenome:HGNC:18327 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity. Involved in positive regulation of cellular senescence. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 26.2), brain (RPKM 22.3) and 25 other tissues See more Orthologs mouse all
YPEL4, Official Symbol YPEL4provided by HGNC Official Full Name yippee like 4provided by HGNC Primary source HGNC:HGNC:18328 See related Ensembl:ENSG00000166793 MIM:609725; AllianceGenome:HGNC:18328 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 4.8), bone marrow (RPKM 3.2) and 12 other tissues See more Orthologs mouse all
YPEL5, Official Symbol YPEL5provided by HGNC Official Full Name yippee like 5provided by HGNC Primary source HGNC:HGNC:18329 See related Ensembl:ENSG00000119801 MIM:609726; AllianceGenome:HGNC:18329 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-127 Summary Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 117.0), testis (RPKM 35.1) and 24 other tissues See more Orthologs mouse all
YRDC, Official Symbol YRDCprovided by HGNC Official Full Name yrdC N6-threonylcarbamoyltransferase domain containingprovided by HGNC Primary source HGNC:HGNC:28905 See related Ensembl:ENSG00000196449 MIM:612276; AllianceGenome:HGNC:28905 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRIP; SUA5; DRIP3; GAMOS10 Summary Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Acts upstream of or within negative regulation of transport. Predicted to be located in membrane and mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 17.4), testis (RPKM 11.7) and 25 other tissues See more Orthologs mouse all
YRDCP1, Official Symbol YRDCP1provided by HGNC Official Full Name yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 1provided by HGNC Primary source HGNC:HGNC:39919 See related Ensembl:ENSG00000278486 AllianceGenome:HGNC:39919 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YRDCP2, Official Symbol YRDCP2provided by HGNC Official Full Name yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 2provided by HGNC Primary source HGNC:HGNC:39920 See related Ensembl:ENSG00000236745 AllianceGenome:HGNC:39920 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YRDCP3, Official Symbol YRDCP3provided by HGNC Official Full Name yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 3provided by HGNC Primary source HGNC:HGNC:39921 See related Ensembl:ENSG00000230859 AllianceGenome:HGNC:39921 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
YTHDC1, Official Symbol YTHDC1provided by HGNC Official Full Name YTH N6-methyladenosine RNA binding protein C1provided by HGNC Primary source HGNC:HGNC:30626 See related Ensembl:ENSG00000083896 MIM:617283; AllianceGenome:HGNC:30626 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YT521; YT521-B Summary Enables N6-methyladenosine-containing RNA binding activity. Involved in mRNA export from nucleus; mRNA splice site selection; and regulation of gene expression. Located in nuclear speck and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 22.7), ovary (RPKM 15.2) and 25 other tissues See more Orthologs mouse all
YTHDC2, Official Symbol YTHDC2provided by HGNC Official Full Name YTH N6-methyladenosine RNA binding protein C2provided by HGNC Primary source HGNC:HGNC:24721 See related Ensembl:ENSG00000047188 MIM:616530; AllianceGenome:HGNC:24721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAHL; hYTHDC2 Summary This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in testis (RPKM 9.0), lymph node (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
YTHDF1, Official Symbol YTHDF1provided by HGNC Official Full Name YTH N6-methyladenosine RNA binding protein F1provided by HGNC Primary source HGNC:HGNC:15867 See related Ensembl:ENSG00000149658 MIM:616529; AllianceGenome:HGNC:15867 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DF1; C20orf21 Summary Enables N6-methyladenosine-containing RNA binding activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 18.6), bone marrow (RPKM 15.2) and 25 other tissues See more Orthologs mouse all
YTHDF1P1, Official Symbol YTHDF1P1provided by HGNC Official Full Name YTH domain family member 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:31681 See related Ensembl:ENSG00000251389 AllianceGenome:HGNC:31681 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YTHDF1P
YTHDF2, Official Symbol YTHDF2provided by HGNC Official Full Name YTH N6-methyladenosine RNA binding protein F2provided by HGNC Primary source HGNC:HGNC:31675 See related Ensembl:ENSG00000198492 MIM:610640; AllianceGenome:HGNC:31675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DF2; CAHL; HGRG8; NY-REN-2 Summary This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in bone marrow (RPKM 23.8), testis (RPKM 20.2) and 25 other tissues See more Orthologs mouse all