psui3905/ncbi_genes_summary huggingface dataset:
MICB, Official Symbol MICBprovided by HGNC Official Full Name MHC class I polypeptide-related sequence Bprovided by HGNC Primary source HGNC:HGNC:7091 See related Ensembl:ENSG00000204516 IMGT/GENE-DB:MICB; MIM:602436; AllianceGenome:HGNC:7091 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PERB11.2 Summary This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Broad expression in lymph node (RPKM 4.7), bone marrow (RPKM 4.2) and 20 other tissues See more Orthologs all
MICB-DT, Official Symbol MICB-DTprovided by HGNC Official Full Name MICB divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53632 See related Ensembl:ENSG00000286940 AllianceGenome:HGNC:53632 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCONS_00012692 Expression Low expression observed in reference dataset See more
MICF, Official Symbol MICFprovided by HGNC Official Full Name MHC class I polypeptide-related sequence F (pseudogene)provided by HGNC Primary source HGNC:HGNC:16801 See related AllianceGenome:HGNC:16801 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MICOS10, Official Symbol MICOS10provided by HGNC Official Full Name mitochondrial contact site and cristae organizing system subunit 10provided by HGNC Primary source HGNC:HGNC:32068 See related Ensembl:ENSG00000173436 MIM:616574; AllianceGenome:HGNC:32068 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIO10; Mic10; MINOS1; C1orf151 Summary Predicted to be involved in inner mitochondrial membrane organization. Located in mitochondrion. Part of MIB complex; MICOS complex; and SAM complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 13.8), kidney (RPKM 11.9) and 25 other tissues See more Orthologs mouse all
MICOS13, Official Symbol MICOS13provided by HGNC Official Full Name mitochondrial contact site and cristae organizing system subunit 13provided by HGNC Primary source HGNC:HGNC:33702 See related Ensembl:ENSG00000174917 MIM:616658; AllianceGenome:HGNC:33702 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P117; QIL1; MIC12; MIC13; C19orf70 Summary Involved in cristae formation. Located in mitochondrial crista junction and nucleoplasm. Part of MICOS complex. Implicated in combined oxidative phosphorylation deficiency 37. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 20.0), testis (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
MICU1, Official Symbol MICU1provided by HGNC Official Full Name mitochondrial calcium uptake 1provided by HGNC Primary source HGNC:HGNC:1530 See related Ensembl:ENSG00000107745 MIM:605084; AllianceGenome:HGNC:1530 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CALC; EFHA3; MPXPS; CBARA1; ara CALC Summary This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] Expression Ubiquitous expression in kidney (RPKM 30.5), adrenal (RPKM 20.9) and 25 other tissues See more Orthologs mouse all
MICU2, Official Symbol MICU2provided by HGNC Official Full Name mitochondrial calcium uptake 2provided by HGNC Primary source HGNC:HGNC:31830 See related Ensembl:ENSG00000165487 MIM:610632; AllianceGenome:HGNC:31830 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EFHA1; 1110008L20Rik Summary Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 25.3), adrenal (RPKM 19.4) and 25 other tissues See more Orthologs mouse all
MICU3, Official Symbol MICU3provided by HGNC Official Full Name mitochondrial calcium uptake family member 3provided by HGNC Primary source HGNC:HGNC:27820 See related Ensembl:ENSG00000155970 MIM:610633; AllianceGenome:HGNC:27820 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EFHA2 Summary Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be located in mitochondrial inner membrane. Predicted to be part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 2.9), adrenal (RPKM 1.3) and 23 other tissues See more Orthologs mouse all
MID1, Official Symbol MID1provided by HGNC Official Full Name midline 1provided by HGNC Primary source HGNC:HGNC:7095 See related Ensembl:ENSG00000101871 MIM:300552; AllianceGenome:HGNC:7095 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OS; FXY; OSX; GBBB; OGS1; XPRF; BBBG1; GBBB1; MIDIN; RNF59; ZNFXY; TRIM18 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in prostate (RPKM 2.5), urinary bladder (RPKM 2.3) and 24 other tissues See more Orthologs mouse all
MID1IP1, Official Symbol MID1IP1provided by HGNC Official Full Name MID1 interacting protein 1provided by HGNC Primary source HGNC:HGNC:20715 See related Ensembl:ENSG00000165175 MIM:300961; AllianceGenome:HGNC:20715 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S14R; MIG12; THRSPL; G12-like; STRAIT11499 Summary Predicted to enable identical protein binding activity and protein C-terminus binding activity. Predicted to be involved in several processes, including negative regulation of microtubule depolymerization; positive regulation of fatty acid biosynthetic process; and protein polymerization. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 21.2), fat (RPKM 16.5) and 25 other tissues See more Orthologs mouse all
MID2, Official Symbol MID2provided by HGNC Official Full Name midline 2provided by HGNC Primary source HGNC:HGNC:7096 See related Ensembl:ENSG00000080561 MIM:300204; AllianceGenome:HGNC:7096 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FXY2; RNF60; TRIM1; MRX101; XLID101 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] Expression Ubiquitous expression in thyroid (RPKM 3.8), fat (RPKM 3.4) and 24 other tissues See more Orthologs mouse all
MIDEAS, Official Symbol MIDEASprovided by HGNC Official Full Name mitotic deacetylase associated SANT domain proteinprovided by HGNC Primary source HGNC:HGNC:19853 See related Ensembl:ENSG00000156030 AllianceGenome:HGNC:19853 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LSR68; ELMSAN1; C14orf43; c14_5541; C14orf117 Summary Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 10.0), ovary (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
MIDN, Official Symbol MIDNprovided by HGNC Official Full Name midnolinprovided by HGNC Primary source HGNC:HGNC:16298 See related Ensembl:ENSG00000167470 MIM:606700; AllianceGenome:HGNC:16298 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Stx Summary Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of glucokinase activity and negative regulation of insulin secretion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 27.5), gall bladder (RPKM 18.8) and 25 other tissues See more Orthologs mouse all
MIEF1, Official Symbol MIEF1provided by HGNC Official Full Name mitochondrial elongation factor 1provided by HGNC Primary source HGNC:HGNC:25979 See related Ensembl:ENSG00000100335 MIM:615497; AllianceGenome:HGNC:25979 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D3A; MID51; L0R8F8; SMCR7L; AltMIEF1; HSU79252; MIEF1-MP; dJ1104E15.3 Summary Enables ADP binding activity; GDP binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of mitochondrial fission; positive regulation of mitochondrial translation; and positive regulation of protein targeting to membrane. Located in mitochondrial matrix and mitochondrial outer membrane. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 13.7), kidney (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
MIEF2, Official Symbol MIEF2provided by HGNC Official Full Name mitochondrial elongation factor 2provided by HGNC Primary source HGNC:HGNC:17920 See related Ensembl:ENSG00000177427 MIM:615498; AllianceGenome:HGNC:17920 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D3B; MID49; SMCR7; COXPD49 Summary This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] Expression Ubiquitous expression in ovary (RPKM 4.6), kidney (RPKM 4.0) and 25 other tissues See more Orthologs mouse all
MIEN1, Official Symbol MIEN1provided by HGNC Official Full Name migration and invasion enhancer 1provided by HGNC Primary source HGNC:HGNC:28230 See related Ensembl:ENSG00000141741 MIM:611802; AllianceGenome:HGNC:28230 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C35; ORB3; XTP4; RDX12; C17orf37 Summary Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is intrinsic component of the cytoplasmic side of the plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 15.4), esophagus (RPKM 14.3) and 25 other tissues See more Orthologs mouse all
MIER1, Official Symbol MIER1provided by HGNC Official Full Name MIER1 transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:29657 See related Ensembl:ENSG00000198160 MIM:616848; AllianceGenome:HGNC:29657 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ER1; MI-ER1 Summary This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013] Expression Ubiquitous expression in bone marrow (RPKM 19.6), colon (RPKM 10.3) and 24 other tissues See more Orthologs mouse all
MIER2, Official Symbol MIER2provided by HGNC Official Full Name MIER family member 2provided by HGNC Primary source HGNC:HGNC:29210 See related Ensembl:ENSG00000105556 MIM:620092; AllianceGenome:HGNC:29210 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mi-er2; KIAA1193 Summary Enables histone deacetylase binding activity. Contributes to histone deacetylase activity. Involved in histone deacetylation. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 6.0), spleen (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
MIER3, Official Symbol MIER3provided by HGNC Official Full Name MIER family member 3provided by HGNC Primary source HGNC:HGNC:26678 See related Ensembl:ENSG00000155545 MIM:620100; AllianceGenome:HGNC:26678 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 18.3), duodenum (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
MIF, Official Symbol MIFprovided by HGNC Official Full Name macrophage migration inhibitory factorprovided by HGNC Primary source HGNC:HGNC:7097 See related Ensembl:ENSG00000240972 MIM:153620; AllianceGenome:HGNC:7097 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GIF; GLIF; MMIF Summary This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 164.4), prostate (RPKM 93.1) and 21 other tissues See more Orthologs mouse all
MIF4GD, Official Symbol MIF4GDprovided by HGNC Official Full Name MIF4G domain containingprovided by HGNC Primary source HGNC:HGNC:24030 See related Ensembl:ENSG00000125457 MIM:612072; AllianceGenome:HGNC:24030 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIFD; AD023; SLIP1 Summary This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] Expression Ubiquitous expression in lymph node (RPKM 9.4), bone marrow (RPKM 8.3) and 25 other tissues See more Orthologs mouse all
MIF4GD-DT, Official Symbol MIF4GD-DTprovided by HGNC Official Full Name MIF4GD divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55335 See related Ensembl:ENSG00000263843 AllianceGenome:HGNC:55335 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MIGA1, Official Symbol MIGA1provided by HGNC Official Full Name mitoguardin 1provided by HGNC Primary source HGNC:HGNC:24741 See related Ensembl:ENSG00000180488 MIM:616773; AllianceGenome:HGNC:24741 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM73A Summary Enables protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Located in mitochondrion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 8.8), thyroid (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
MIGA2, Official Symbol MIGA2provided by HGNC Official Full Name mitoguardin 2provided by HGNC Primary source HGNC:HGNC:23621 See related Ensembl:ENSG00000148343 MIM:616774; AllianceGenome:HGNC:23621 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM73B; C9orf54 Summary Enables protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 12.6), small intestine (RPKM 10.8) and 25 other tissues See more Orthologs mouse all
MIIP, Official Symbol MIIPprovided by HGNC Official Full Name migration and invasion inhibitory proteinprovided by HGNC Primary source HGNC:HGNC:25715 See related Ensembl:ENSG00000116691 MIM:608772; AllianceGenome:HGNC:25715 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IIP45 Summary This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 8.7) and 24 other tissues See more Orthologs mouse all
MILR1, Official Symbol MILR1provided by HGNC Official Full Name mast cell immunoglobulin like receptor 1provided by HGNC Primary source HGNC:HGNC:27570 See related Ensembl:ENSG00000271605 AllianceGenome:HGNC:27570 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCA32; MCA-32; C17orf60; Allergin-1 Summary Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell-cell adhesion via plasma-membrane adhesion molecules; mast cell degranulation; and negative regulation of mast cell activation. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in appendix (RPKM 7.6), lymph node (RPKM 6.4) and 21 other tissues See more Orthologs mouse all
MIMT1, Official Symbol MIMT1provided by HGNC Official Full Name MER1 repeat containing imprinted transcript 1provided by HGNC Primary source HGNC:HGNC:33464 See related Ensembl:ENSG00000268654 MIM:620407; AllianceGenome:HGNC:33464 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIM1; LINC00067; NCRNA00067 Expression Biased expression in testis (RPKM 3.5), ovary (RPKM 1.3) and 3 other tissues See more
MINAR1, Official Symbol MINAR1provided by HGNC Official Full Name membrane integral NOTCH2 associated receptor 1provided by HGNC Primary source HGNC:HGNC:29172 See related Ensembl:ENSG00000169330 MIM:618054; AllianceGenome:HGNC:29172 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBTOR; KIAA1024 Summary Involved in several processes, including negative regulation of TOR signaling; negative regulation of angiogenesis; and negative regulation of protein ubiquitination. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in adrenal (RPKM 4.7), salivary gland (RPKM 0.6) and 1 other tissue See more Orthologs mouse all
MINAR2, Official Symbol MINAR2provided by HGNC Official Full Name membrane integral NOTCH2 associated receptor 2provided by HGNC Primary source HGNC:HGNC:33914 See related Ensembl:ENSG00000186367 MIM:620215; AllianceGenome:HGNC:33914 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB120; KIAA1024L Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
MINCR, Official Symbol MINCRprovided by HGNC Official Full Name MYC-induced long non-coding RNAprovided by HGNC Primary source HGNC:HGNC:51653 See related Ensembl:ENSG00000253716 AllianceGenome:HGNC:51653 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01604 Expression Ubiquitous expression in fat (RPKM 4.1), thyroid (RPKM 2.9) and 25 other tissues See more
MINDY1, Official Symbol MINDY1provided by HGNC Official Full Name MINDY lysine 48 deubiquitinase 1provided by HGNC Primary source HGNC:HGNC:25648 See related Ensembl:ENSG00000143409 MIM:618407; AllianceGenome:HGNC:25648 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM63A; MINDY-1 Summary Enables K48-linked polyubiquitin modification-dependent protein binding activity; Lys48-specific deubiquitinase activity; and cysteine-type carboxypeptidase activity. Predicted to be involved in protein K48-linked deubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 17.7), testis (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
MINDY2, Official Symbol MINDY2provided by HGNC Official Full Name MINDY lysine 48 deubiquitinase 2provided by HGNC Primary source HGNC:HGNC:26954 See related Ensembl:ENSG00000128923 MIM:618408; AllianceGenome:HGNC:26954 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM63B Summary Enables cysteine-type peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in protein K48-linked deubiquitination. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.3), fat (RPKM 6.3) and 25 other tissues See more Orthologs mouse all
MINDY3, Official Symbol MINDY3provided by HGNC Official Full Name MINDY lysine 48 deubiquitinase 3provided by HGNC Primary source HGNC:HGNC:23578 See related Ensembl:ENSG00000148481 MIM:611649; AllianceGenome:HGNC:23578 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CARP; DERP5; my042; MST126; FAM188A; MSTP126; C10orf97 Summary The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in bone marrow (RPKM 5.8), adrenal (RPKM 4.8) and 25 other tissues See more Orthologs mouse all
MINDY4, Official Symbol MINDY4provided by HGNC Official Full Name MINDY lysine 48 deubiquitinase 4provided by HGNC Primary source HGNC:HGNC:21916 See related Ensembl:ENSG00000106125 AllianceGenome:HGNC:21916 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AQP1; AQP-1; CHIP28; C7orf67; FAM188B Summary Predicted to enable Lys48-specific deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 8.1), lung (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
MINDY4B, Official Symbol MINDY4Bprovided by HGNC Official Full Name MINDY family member 4Bprovided by HGNC Primary source HGNC:HGNC:35475 See related Ensembl:ENSG00000214237 AllianceGenome:HGNC:35475 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3orf76; FAM188B2 Summary Predicted to enable Lys48-specific deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
MINK1, Official Symbol MINK1provided by HGNC Official Full Name misshapen like kinase 1provided by HGNC Primary source HGNC:HGNC:17565 See related Ensembl:ENSG00000141503 MIM:609426; AllianceGenome:HGNC:17565 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B55; ZC3; MINK; YSK2; MAP4K6; MEKKK 6 Summary This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in skin (RPKM 48.7), brain (RPKM 31.3) and 25 other tissues See more Orthologs mouse all
MINPP1, Official Symbol MINPP1provided by HGNC Official Full Name multiple inositol-polyphosphate phosphatase 1provided by HGNC Primary source HGNC:HGNC:7102 See related Ensembl:ENSG00000107789 MIM:605391; AllianceGenome:HGNC:7102 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIPP; PCH16; HIPER1; MINPP2 Summary This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009] Expression Ubiquitous expression in bone marrow (RPKM 5.4), adrenal (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
MIOS, Official Symbol MIOSprovided by HGNC Official Full Name meiosis regulator for oocyte developmentprovided by HGNC Primary source HGNC:HGNC:21905 See related Ensembl:ENSG00000164654 MIM:615359; AllianceGenome:HGNC:21905 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIO; Sea4; Yulink Summary Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 7.9), testis (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
MIOX, Official Symbol MIOXprovided by HGNC Official Full Name myo-inositol oxygenaseprovided by HGNC Primary source HGNC:HGNC:14522 See related Ensembl:ENSG00000100253 MIM:606774; AllianceGenome:HGNC:14522 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALDRL6 Summary Enables ferric iron binding activity and inositol oxygenase activity. Involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward kidney (RPKM 162.3) See more Orthologs mouse all
MIOXP1, Official Symbol MIOXP1provided by HGNC Official Full Name myo-inositol oxygenase pseudogene 1provided by HGNC Primary source HGNC:HGNC:50748 See related Ensembl:ENSG00000253292 AllianceGenome:HGNC:50748 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MIP, Official Symbol MIPprovided by HGNC Official Full Name major intrinsic protein of lens fiberprovided by HGNC Primary source HGNC:HGNC:7103 See related Ensembl:ENSG00000135517 MIM:154050; AllianceGenome:HGNC:7103 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AQP0; LIM1; MP26; MIP26; CTRCT15 Summary Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
MIPEP, Official Symbol MIPEPprovided by HGNC Official Full Name mitochondrial intermediate peptidaseprovided by HGNC Primary source HGNC:HGNC:7104 See related Ensembl:ENSG00000027001 MIM:602241; AllianceGenome:HGNC:7104 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIP; HMIP; COXPD31 Summary The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 8.2), skin (RPKM 7.7) and 25 other tissues See more Orthologs mouse all
MIPOL1, Official Symbol MIPOL1provided by HGNC Official Full Name mirror-image polydactyly 1provided by HGNC Primary source HGNC:HGNC:21460 See related Ensembl:ENSG00000151338 MIM:606850; AllianceGenome:HGNC:21460 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCDC193 Summary This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2010] Expression Broad expression in prostate (RPKM 1.7), testis (RPKM 0.6) and 20 other tissues See more Orthologs mouse all
MIR1-1, Official Symbol MIR1-1provided by HGNC Official Full Name microRNA 1-1provided by HGNC Primary source HGNC:HGNC:31499 See related Ensembl:ENSG00000199017 MIM:609326; miRBase:MI0000651; AllianceGenome:HGNC:31499 Gene type ncRNA RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIRN1-1; mir-1-1; miRNA1-1; hsa-mir-1-1 Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR1-1HG, Official Symbol MIR1-1HGprovided by HGNC Official Full Name MIR1-1 host geneprovided by HGNC Primary source HGNC:HGNC:16159 See related Ensembl:ENSG00000174407 AllianceGenome:HGNC:16159 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C20orf166; MIR133A2HG Expression Biased expression in heart (RPKM 1.7), prostate (RPKM 1.3) and 3 other tissues See more Orthologs all
MIR1-2, Official Symbol MIR1-2provided by HGNC Official Full Name microRNA 1-2provided by HGNC Primary source HGNC:HGNC:31500 See related Ensembl:ENSG00000284453 MIM:610252; miRBase:MI0000437; AllianceGenome:HGNC:31500 Gene type ncRNA RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIRN1-2; mir-1-2; miRNA1-2; hsa-mir-1-2 Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR100, Official Symbol MIR100provided by HGNC Official Full Name microRNA 100provided by HGNC Primary source HGNC:HGNC:31487 See related Ensembl:ENSG00000207994 MIM:613186; miRBase:MI0000102; AllianceGenome:HGNC:31487 Gene type ncRNA RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIRN100; miR-100 Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR100HG, Official Symbol MIR100HGprovided by HGNC Official Full Name mir-100-let-7a-2-mir-125b-1 cluster host geneprovided by HGNC Primary source HGNC:HGNC:39522 See related Ensembl:ENSG00000255248 MIM:615965; AllianceGenome:HGNC:39522 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGD1; lncRNA-N2; linc-NeD125 Summary This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division. [provided by RefSeq, May 2016] Expression Broad expression in ovary (RPKM 32.2), gall bladder (RPKM 20.3) and 18 other tissues See more Orthologs mouse all
MIR101-1, Official Symbol MIR101-1provided by HGNC Official Full Name microRNA 101-1provided by HGNC Primary source HGNC:HGNC:31488 See related Ensembl:ENSG00000199135 MIM:612511; miRBase:MI0000103; AllianceGenome:HGNC:31488 Gene type ncRNA RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIRN101-1; mir-101-1 Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR101-2, Official Symbol MIR101-2provided by HGNC Official Full Name microRNA 101-2provided by HGNC Primary source HGNC:HGNC:31489 See related Ensembl:ENSG00000199065 MIM:612512; miRBase:MI0000739; AllianceGenome:HGNC:31489 Gene type ncRNA RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIRN101-2; mir-101-2 Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]