psui3905/ncbi_genes_summary huggingface dataset:
TNFRSF4, Official Symbol TNFRSF4provided by HGNC Official Full Name TNF receptor superfamily member 4provided by HGNC Primary source HGNC:HGNC:11918 See related Ensembl:ENSG00000186827 MIM:600315; AllianceGenome:HGNC:11918 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OX40; ACT35; CD134; IMD16; TXGP1L Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues See more Orthologs mouse all
TNFRSF6B, Official Symbol TNFRSF6Bprovided by HGNC Official Full Name TNF receptor superfamily member 6bprovided by HGNC Primary source HGNC:HGNC:11921 See related Ensembl:ENSG00000243509 MIM:603361; AllianceGenome:HGNC:11921 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M68; TR6; DCR3; M68E; DJ583P15.1.1 Summary This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011] Expression Broad expression in appendix (RPKM 7.2), spleen (RPKM 3.2) and 20 other tissues See more Orthologs all
TNFRSF8, Official Symbol TNFRSF8provided by HGNC Official Full Name TNF receptor superfamily member 8provided by HGNC Primary source HGNC:HGNC:11923 See related Ensembl:ENSG00000120949 MIM:153243; AllianceGenome:HGNC:11923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD30; Ki-1; D1S166E Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 1.3), fat (RPKM 1.0) and 17 other tissues See more Orthologs mouse all
TNFRSF9, Official Symbol TNFRSF9provided by HGNC Official Full Name TNF receptor superfamily member 9provided by HGNC Primary source HGNC:HGNC:11924 See related Ensembl:ENSG00000049249 MIM:602250; AllianceGenome:HGNC:11924 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILA; 4-1BB; CD137; CDw137; IMD109 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 2.6), appendix (RPKM 1.1) and 6 other tissues See more Orthologs mouse all
TNFSF10, Official Symbol TNFSF10provided by HGNC Official Full Name TNF superfamily member 10provided by HGNC Primary source HGNC:HGNC:11925 See related Ensembl:ENSG00000121858 MIM:603598; AllianceGenome:HGNC:11925 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in lung (RPKM 64.9), placenta (RPKM 44.9) and 21 other tissues See more Orthologs mouse all
TNFSF11, Official Symbol TNFSF11provided by HGNC Official Full Name TNF superfamily member 11provided by HGNC Primary source HGNC:HGNC:11926 See related Ensembl:ENSG00000120659 MIM:602642; AllianceGenome:HGNC:11926 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2 Summary This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 4.9), appendix (RPKM 2.0) and 6 other tissues See more Orthologs mouse all
TNFSF12, Official Symbol TNFSF12provided by HGNC Official Full Name TNF superfamily member 12provided by HGNC Primary source HGNC:HGNC:11927 See related Ensembl:ENSG00000239697 MIM:602695; AllianceGenome:HGNC:11927 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APO3L; DR3LG; TWEAK; TNLG4A Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in fat (RPKM 27.5), lung (RPKM 20.2) and 25 other tissues See more Orthologs mouse all
TNFSF12-TNFSF13, Official Symbol TNFSF12-TNFSF13provided by HGNC Official Full Name TNFSF12-TNFSF13 readthroughprovided by HGNC Primary source HGNC:HGNC:33537 See related Ensembl:ENSG00000248871 AllianceGenome:HGNC:33537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TWE-PRIL Summary This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 41.7), gall bladder (RPKM 26.6) and 25 other tissues See more Orthologs all
TNFSF13, Official Symbol TNFSF13provided by HGNC Official Full Name TNF superfamily member 13provided by HGNC Primary source HGNC:HGNC:11928 See related Ensembl:ENSG00000161955 MIM:604472; AllianceGenome:HGNC:11928 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715 Summary The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in lung (RPKM 37.5), gall bladder (RPKM 25.6) and 25 other tissues See more Orthologs mouse all
TNFSF13B, Official Symbol TNFSF13Bprovided by HGNC Official Full Name TNF superfamily member 13bprovided by HGNC Primary source HGNC:HGNC:11929 See related Ensembl:ENSG00000102524 MIM:603969; AllianceGenome:HGNC:11929 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20 Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] Expression Broad expression in appendix (RPKM 11.4), lymph node (RPKM 7.1) and 21 other tissues See more Orthologs mouse all
TNFSF14, Official Symbol TNFSF14provided by HGNC Official Full Name TNF superfamily member 14provided by HGNC Primary source HGNC:HGNC:11930 See related Ensembl:ENSG00000125735 MIM:604520; AllianceGenome:HGNC:11930 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LTg; CD258; HVEML; LIGHT Summary The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 1.5), appendix (RPKM 0.9) and 18 other tissues See more Orthologs mouse all
TNFSF15, Official Symbol TNFSF15provided by HGNC Official Full Name TNF superfamily member 15provided by HGNC Primary source HGNC:HGNC:11931 See related Ensembl:ENSG00000181634 MIM:604052; AllianceGenome:HGNC:11931 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TL1; TL1A; VEGI; TNLG1B; VEGI192A Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Expression Broad expression in duodenum (RPKM 4.3), urinary bladder (RPKM 3.6) and 17 other tissues See more Orthologs mouse all
TNFSF18, Official Symbol TNFSF18provided by HGNC Official Full Name TNF superfamily member 18provided by HGNC Primary source HGNC:HGNC:11932 See related Ensembl:ENSG00000120337 MIM:603898; AllianceGenome:HGNC:11932 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TL6; AITRL; GITRL; TNLG2A; hGITRL Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 1.2), brain (RPKM 1.0) and 16 other tissues See more Orthologs mouse all
TNFSF4, Official Symbol TNFSF4provided by HGNC Official Full Name TNF superfamily member 4provided by HGNC Primary source HGNC:HGNC:11934 See related Ensembl:ENSG00000117586 MIM:603594; AllianceGenome:HGNC:11934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B Summary This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all
TNFSF8, Official Symbol TNFSF8provided by HGNC Official Full Name TNF superfamily member 8provided by HGNC Primary source HGNC:HGNC:11938 See related Ensembl:ENSG00000106952 MIM:603875; AllianceGenome:HGNC:11938 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD153; CD30L; CD30LG; TNLG3A Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Expression Biased expression in lymph node (RPKM 9.3), appendix (RPKM 6.6) and 11 other tissues See more Orthologs mouse all
TNFSF9, Official Symbol TNFSF9provided by HGNC Official Full Name TNF superfamily member 9provided by HGNC Primary source HGNC:HGNC:11939 See related Ensembl:ENSG00000125657 MIM:606182; AllianceGenome:HGNC:11939 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD137L; TNLG5A; 4-1BB-L Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008] Expression Broad expression in colon (RPKM 1.1), bone marrow (RPKM 1.0) and 18 other tissues See more Orthologs mouse all
TNIK, Official Symbol TNIKprovided by HGNC Official Full Name TRAF2 and NCK interacting kinaseprovided by HGNC Primary source HGNC:HGNC:30765 See related Ensembl:ENSG00000154310 MIM:610005; AllianceGenome:HGNC:30765 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT54 Summary Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017] Expression Broad expression in brain (RPKM 10.5), small intestine (RPKM 7.1) and 20 other tissues See more Orthologs mouse all
TNIP1, Official Symbol TNIP1provided by HGNC Official Full Name TNFAIP3 interacting protein 1provided by HGNC Primary source HGNC:HGNC:16903 See related Ensembl:ENSG00000145901 MIM:607714; AllianceGenome:HGNC:16903 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VAN; NAF1; ABIN-1; nip40-1 Summary This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in fat (RPKM 55.9), spleen (RPKM 36.4) and 25 other tissues See more Orthologs mouse all
TNIP2, Official Symbol TNIP2provided by HGNC Official Full Name TNFAIP3 interacting protein 2provided by HGNC Primary source HGNC:HGNC:19118 See related Ensembl:ENSG00000168884 MIM:610669; AllianceGenome:HGNC:19118 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLIP; ABIN2; FLIP1 Summary This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014] Expression Ubiquitous expression in small intestine (RPKM 12.1), colon (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
TNIP3, Official Symbol TNIP3provided by HGNC Official Full Name TNFAIP3 interacting protein 3provided by HGNC Primary source HGNC:HGNC:19315 See related Ensembl:ENSG00000050730 MIM:608019; AllianceGenome:HGNC:19315 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIND; ABIN-3 Summary Enables polyubiquitin modification-dependent protein binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB signaling; and toll-like receptor signaling pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in appendix (RPKM 1.2), lymph node (RPKM 0.4) and 11 other tissues See more Orthologs mouse all
TNK1, Official Symbol TNK1provided by HGNC Official Full Name tyrosine kinase non receptor 1provided by HGNC Primary source HGNC:HGNC:11940 See related Ensembl:ENSG00000174292 MIM:608076; AllianceGenome:HGNC:11940 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KOS1 Summary The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in stomach (RPKM 6.3), duodenum (RPKM 4.1) and 23 other tissues See more Orthologs mouse all
TNK2, Official Symbol TNK2provided by HGNC Official Full Name tyrosine kinase non receptor 2provided by HGNC Primary source HGNC:HGNC:19297 See related Ensembl:ENSG00000061938 MIM:606994; AllianceGenome:HGNC:19297 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACK; ACK1; ACK-1; p21cdc42Hs Summary This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues See more Orthologs mouse all
TNKS, Official Symbol TNKSprovided by HGNC Official Full Name tankyraseprovided by HGNC Primary source HGNC:HGNC:11941 See related Ensembl:ENSG00000173273 MIM:603303; AllianceGenome:HGNC:11941 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a Summary Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 8.6), brain (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
TNKS1BP1, Official Symbol TNKS1BP1provided by HGNC Official Full Name tankyrase 1 binding protein 1provided by HGNC Primary source HGNC:HGNC:19081 See related Ensembl:ENSG00000149115 MIM:607104; AllianceGenome:HGNC:19081 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNOT12; TAB182 Summary Enables ankyrin repeat binding activity and enzyme binding activity. Involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Located in several cellular components, including actin cytoskeleton; adherens junction; and heterochromatin. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 32.4), fat (RPKM 31.8) and 24 other tissues See more Orthologs mouse all
TNKS2, Official Symbol TNKS2provided by HGNC Official Full Name tankyrase 2provided by HGNC Primary source HGNC:HGNC:15677 See related Ensembl:ENSG00000107854 MIM:607128; AllianceGenome:HGNC:15677 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c Summary Enables NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues See more Orthologs mouse all
TNMD, Official Symbol TNMDprovided by HGNC Official Full Name tenomodulinprovided by HGNC Primary source HGNC:HGNC:17757 See related Ensembl:ENSG00000000005 MIM:300459; AllianceGenome:HGNC:17757 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEM; CHM1L; BRICD4 Summary This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009] Expression Biased expression in fat (RPKM 8.0), placenta (RPKM 1.2) and 2 other tissues See more Orthologs mouse all
TNN, Official Symbol TNNprovided by HGNC Official Full Name tenascin Nprovided by HGNC Primary source HGNC:HGNC:22942 See related Ensembl:ENSG00000120332 MIM:617472; AllianceGenome:HGNC:22942 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNW; TN-W Summary Predicted to enable integrin binding activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; and negative regulation of osteoblast differentiation. Predicted to act upstream of or within axonogenesis. Predicted to be located in extracellular matrix and neuron projection. Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 11.1), thyroid (RPKM 1.5) and 2 other tissues See more Orthologs mouse all
TNNC1, Official Symbol TNNC1provided by HGNC Official Full Name troponin C1, slow skeletal and cardiac typeprovided by HGNC Primary source HGNC:HGNC:11943 See related Ensembl:ENSG00000114854 MIM:191040; AllianceGenome:HGNC:11943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNC; TN-C; TNNC; CMD1Z; CMH13 Summary Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008] Expression Restricted expression toward heart (RPKM 1964.8) See more Orthologs mouse all
TNNC2, Official Symbol TNNC2provided by HGNC Official Full Name troponin C2, fast skeletal typeprovided by HGNC Primary source HGNC:HGNC:11944 See related Ensembl:ENSG00000101470 MIM:191039; AllianceGenome:HGNC:11944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAP85; CFAP85; CMYP15; MYONRI Summary Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 45.9) and esophagus (RPKM 37.4) See more Orthologs mouse all
TNNI1, Official Symbol TNNI1provided by HGNC Official Full Name troponin I1, slow skeletal typeprovided by HGNC Primary source HGNC:HGNC:11945 See related Ensembl:ENSG00000159173 MIM:191042; AllianceGenome:HGNC:11945 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNN1; SSTNI Summary Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 22.0), prostate (RPKM 20.7) and 2 other tissues See more Orthologs mouse all
TNNI2, Official Symbol TNNI2provided by HGNC Official Full Name troponin I2, fast skeletal typeprovided by HGNC Primary source HGNC:HGNC:11946 See related Ensembl:ENSG00000130598 MIM:191043; AllianceGenome:HGNC:11946 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DA2B; FSSV; DA2B1; fsTnI; AMCD2B Summary This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] Expression Biased expression in esophagus (RPKM 41.2), prostate (RPKM 27.4) and 5 other tissues See more Orthologs mouse all
TNNI3, Official Symbol TNNI3provided by HGNC Official Full Name troponin I3, cardiac typeprovided by HGNC Primary source HGNC:HGNC:11947 See related Ensembl:ENSG00000129991 MIM:191044; AllianceGenome:HGNC:11947 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF Summary Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis. Expression Restricted expression toward heart (RPKM 1543.0) See more Orthologs mouse all
TNNI3K, Official Symbol TNNI3Kprovided by HGNC Official Full Name TNNI3 interacting kinaseprovided by HGNC Primary source HGNC:HGNC:19661 See related Ensembl:ENSG00000116783 MIM:613932; AllianceGenome:HGNC:19661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CARK; CCDD Summary This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012] Expression Biased expression in heart (RPKM 19.3), testis (RPKM 1.3) and 1 other tissue See more Orthologs mouse all
TNNT1, Official Symbol TNNT1provided by HGNC Official Full Name troponin T1, slow skeletal typeprovided by HGNC Primary source HGNC:HGNC:11948 See related Ensembl:ENSG00000105048 MIM:191041; AllianceGenome:HGNC:11948 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANM; TNT; NEM5; STNT; TNTS Summary This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 142.1), prostate (RPKM 132.0) and 2 other tissues See more Orthologs mouse all
TNNT2, Official Symbol TNNT2provided by HGNC Official Full Name troponin T2, cardiac typeprovided by HGNC Primary source HGNC:HGNC:11949 See related Ensembl:ENSG00000118194 MIM:191045; AllianceGenome:HGNC:11949 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6 Summary This gene encodes the cardiac isoform of troponin T. The encoded protein is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. [provided by RefSeq, May 2022] Expression Restricted expression toward heart (RPKM 1647.3) See more Orthologs mouse all
TNNT3, Official Symbol TNNT3provided by HGNC Official Full Name troponin T3, fast skeletal typeprovided by HGNC Primary source HGNC:HGNC:11950 See related Ensembl:ENSG00000130595 MIM:600692; AllianceGenome:HGNC:11950 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNTF; DA2B2; beta-TnTF Summary The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009] Expression Biased expression in esophagus (RPKM 25.1), prostate (RPKM 20.2) and 6 other tissues See more Orthologs mouse all
TNP1, Official Symbol TNP1provided by HGNC Official Full Name transition protein 1provided by HGNC Primary source HGNC:HGNC:11951 See related Ensembl:ENSG00000118245 MIM:190231; AllianceGenome:HGNC:11951 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TP1 Summary Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008] Expression Restricted expression toward testis (RPKM 903.2) See more Orthologs mouse all
TNP2, Official Symbol TNP2provided by HGNC Official Full Name transition protein 2provided by HGNC Primary source HGNC:HGNC:11952 See related Ensembl:ENSG00000178279 MIM:190232; AllianceGenome:HGNC:11952 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TP2 Summary Predicted to enable zinc ion binding activity. Predicted to be involved in positive regulation of protein processing; single fertilization; and spermatogenesis, exchange of chromosomal proteins. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in nucleus. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 12.9) See more Orthologs mouse all
TNPO1, Official Symbol TNPO1provided by HGNC Official Full Name transportin 1provided by HGNC Primary source HGNC:HGNC:6401 See related Ensembl:ENSG00000083312 MIM:602901; AllianceGenome:HGNC:6401 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIP; TRN; IPO2; MIP1; KPNB2 Summary This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018] Expression Ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.9) and 25 other tissues See more Orthologs mouse all