psui3905/ncbi_genes_summary huggingface dataset:
VASH1, Official Symbol VASH1provided by HGNC Official Full Name vasohibin 1provided by HGNC Primary source HGNC:HGNC:19964 See related Ensembl:ENSG00000071246 MIM:609011; AllianceGenome:HGNC:19964 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTCP 1; KIAA1036 Summary Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 12.0), placenta (RPKM 11.8) and 25 other tissues See more Orthologs mouse all
VASH1-AS1, Official Symbol VASH1-AS1provided by HGNC Official Full Name VASH1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53215 See related Ensembl:ENSG00000258301 AllianceGenome:HGNC:53215 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in lung (RPKM 27.5), spleen (RPKM 26.1) and 25 other tissues See more
VASH2, Official Symbol VASH2provided by HGNC Official Full Name vasohibin 2provided by HGNC Primary source HGNC:HGNC:25723 See related Ensembl:ENSG00000143494 MIM:610471; AllianceGenome:HGNC:25723 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables actin binding activity; metallocarboxypeptidase activity; and microtubule binding activity. Involved in axon development and proteolysis. Acts upstream of or within cell-cell fusion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 1.7), esophagus (RPKM 1.3) and 20 other tissues See more Orthologs mouse all
VASN, Official Symbol VASNprovided by HGNC Official Full Name vasorinprovided by HGNC Primary source HGNC:HGNC:18517 See related Ensembl:ENSG00000168140 MIM:608843; AllianceGenome:HGNC:18517 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLITL2 Summary Enables transforming growth factor beta binding activity. Involved in negative regulation of epithelial to mesenchymal transition and negative regulation of transforming growth factor beta receptor signaling pathway. Located in cell surface and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in placenta (RPKM 16.9), kidney (RPKM 16.4) and 24 other tissues See more Orthologs mouse all
VASP, Official Symbol VASPprovided by HGNC Official Full Name vasodilator stimulated phosphoproteinprovided by HGNC Primary source HGNC:HGNC:12652 See related Ensembl:ENSG00000125753 MIM:601703; AllianceGenome:HGNC:12652 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in appendix (RPKM 50.6), spleen (RPKM 48.4) and 25 other tissues See more Orthologs mouse all
VAT1, Official Symbol VAT1provided by HGNC Official Full Name vesicle amine transport 1provided by HGNC Primary source HGNC:HGNC:16919 See related Ensembl:ENSG00000108828 MIM:604631; AllianceGenome:HGNC:16919 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VATI Summary Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 107.1), ovary (RPKM 104.4) and 25 other tissues See more Orthologs mouse all
VAT1L, Official Symbol VAT1Lprovided by HGNC Official Full Name vesicle amine transport 1 likeprovided by HGNC Primary source HGNC:HGNC:29315 See related Ensembl:ENSG00000171724 MIM:620202; AllianceGenome:HGNC:29315 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable oxidoreductase activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in adrenal (RPKM 44.1), brain (RPKM 16.6) and 3 other tissues See more Orthologs mouse all
VAV1, Official Symbol VAV1provided by HGNC Official Full Name vav guanine nucleotide exchange factor 1provided by HGNC Primary source HGNC:HGNC:12657 See related Ensembl:ENSG00000141968 MIM:164875; AllianceGenome:HGNC:12657 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VAV Summary This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] Expression Broad expression in lymph node (RPKM 23.7), appendix (RPKM 21.5) and 16 other tissues See more Orthologs mouse all
VAV2, Official Symbol VAV2provided by HGNC Official Full Name vav guanine nucleotide exchange factor 2provided by HGNC Primary source HGNC:HGNC:12658 See related Ensembl:ENSG00000160293 MIM:600428; AllianceGenome:HGNC:12658 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VAV-2 Summary VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in adrenal (RPKM 10.2), small intestine (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
VAV3, Official Symbol VAV3provided by HGNC Official Full Name vav guanine nucleotide exchange factor 3provided by HGNC Primary source HGNC:HGNC:12659 See related Ensembl:ENSG00000134215 MIM:605541; AllianceGenome:HGNC:12659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 10.0), skin (RPKM 8.3) and 17 other tissues See more Orthologs mouse all
VAV3-AS1, Official Symbol VAV3-AS1provided by HGNC Official Full Name VAV3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40608 See related Ensembl:ENSG00000230489 AllianceGenome:HGNC:40608 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
VAX1, Official Symbol VAX1provided by HGNC Official Full Name ventral anterior homeobox 1provided by HGNC Primary source HGNC:HGNC:12660 See related Ensembl:ENSG00000148704 MIM:604294; AllianceGenome:HGNC:12660 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCOPS11 Summary This gene encodes a homeo-domain containing protein from a class of homeobox transcription factors which are conserved in vertebrates. Genes of this family are involved in the regulation of body development and morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies in the vicinity of the EMX homeobox gene family. Another member of VAX family is located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
VAX2, Official Symbol VAX2provided by HGNC Official Full Name ventral anterior homeobox 2provided by HGNC Primary source HGNC:HGNC:12661 See related Ensembl:ENSG00000116035 MIM:604295; AllianceGenome:HGNC:12661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRES93 Summary This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. [provided by RefSeq, Sep 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
VBP1, Official Symbol VBP1provided by HGNC Official Full Name VHL binding protein 1provided by HGNC Primary source HGNC:HGNC:12662 See related Ensembl:ENSG00000155959 MIM:300133; AllianceGenome:HGNC:12662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFD3; PFDN3; VBP-1; HIBBJ46 Summary The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in brain (RPKM 27.3), heart (RPKM 18.7) and 25 other tissues See more Orthologs mouse all
VCAM1, Official Symbol VCAM1provided by HGNC Official Full Name vascular cell adhesion molecule 1provided by HGNC Primary source HGNC:HGNC:12663 See related Ensembl:ENSG00000162692 MIM:192225; AllianceGenome:HGNC:12663 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD106; INCAM-100 Summary This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] Expression Biased expression in spleen (RPKM 208.8), lymph node (RPKM 52.3) and 7 other tissues See more Orthologs mouse all
VCAN, Official Symbol VCANprovided by HGNC Official Full Name versicanprovided by HGNC Primary source HGNC:HGNC:2464 See related Ensembl:ENSG00000038427 MIM:118661; AllianceGenome:HGNC:2464 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WGN; ERVR; GHAP; PG-M; WGN1; CSPG2 Summary This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] Expression Broad expression in appendix (RPKM 45.0), placenta (RPKM 35.3) and 15 other tissues See more Orthologs mouse all
VCAN-AS1, Official Symbol VCAN-AS1provided by HGNC Official Full Name VCAN antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40163 See related Ensembl:ENSG00000249835 AllianceGenome:HGNC:40163 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
VCL, Official Symbol VCLprovided by HGNC Official Full Name vinculinprovided by HGNC Primary source HGNC:HGNC:12665 See related Ensembl:ENSG00000035403 MIM:193065; AllianceGenome:HGNC:12665 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MV; MVCL; CMD1W; CMH15; HEL114 Summary Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 87.7), prostate (RPKM 70.2) and 25 other tissues See more Orthologs mouse all
VCP, Official Symbol VCPprovided by HGNC Official Full Name valosin containing proteinprovided by HGNC Primary source HGNC:HGNC:12666 See related Ensembl:ENSG00000165280 MIM:601023; AllianceGenome:HGNC:12666 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p97; TERA; CDC48; FTDALS6 Summary This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in appendix (RPKM 60.7), thyroid (RPKM 56.9) and 25 other tissues See more Orthologs mouse all
VCPIP1, Official Symbol VCPIP1provided by HGNC Official Full Name valosin containing protein interacting protein 1provided by HGNC Primary source HGNC:HGNC:30897 See related Ensembl:ENSG00000175073 MIM:611745; AllianceGenome:HGNC:30897 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUBA3; VCIP135 Summary Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 10.6), spleen (RPKM 6.5) and 25 other tissues See more Orthologs mouse all
VCPKMT, Official Symbol VCPKMTprovided by HGNC Official Full Name valosin containing protein lysine methyltransferaseprovided by HGNC Primary source HGNC:HGNC:20352 See related Ensembl:ENSG00000100483 MIM:615260; AllianceGenome:HGNC:20352 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VCP-KMT; METTL21D; C14orf138 Summary Enables ATPase binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of ATPase activity and peptidyl-lysine trimethylation. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 3.1), testis (RPKM 3.0) and 25 other tissues See more Orthologs mouse all
VCX, Official Symbol VCXprovided by HGNC Official Full Name variable charge X-linkedprovided by HGNC Primary source HGNC:HGNC:12667 See related Ensembl:ENSG00000182583 MIM:300229; AllianceGenome:HGNC:12667 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VCX1; VCXB1; VCX-B1; VCX10R; VCX-10r Summary This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 23.7) See more Orthologs all
VCX2, Official Symbol VCX2provided by HGNC Official Full Name variable charge X-linked 2provided by HGNC Primary source HGNC:HGNC:18158 See related Ensembl:ENSG00000177504 MIM:300532; AllianceGenome:HGNC:18158 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VCXB; VCX2R; VCX-2r Summary This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes that are expressed exclusively in male germ cells. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This gene contains two copies of a 30 nt tandem repeat. Deletion of a nearby member of this family was implicated in cognitive disability. [provided by RefSeq, Feb 2015] Expression Restricted expression toward testis (RPKM 16.4) See more
VCX3A, Official Symbol VCX3Aprovided by HGNC Official Full Name variable charge X-linked 3Aprovided by HGNC Primary source HGNC:HGNC:18159 See related Ensembl:ENSG00000169059 MIM:300533; AllianceGenome:HGNC:18159 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VCX3; VCXA; VCX-A; VCX8R; VCX-8r Summary This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 27.7) See more Orthologs all
VCX3B, Official Symbol VCX3Bprovided by HGNC Official Full Name variable charge X-linked 3Bprovided by HGNC Primary source HGNC:HGNC:31838 See related Ensembl:ENSG00000205642 MIM:300981; AllianceGenome:HGNC:31838 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VCXC; VCX-C Summary This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22, and the Y-linked members are two identical copies of the gene within a palindromic region on chromosome Yq11. The family members share a high degree of sequence identity, with the exception that a 30-nt unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This family member, as represented by the reference genome allele, contains 14 copies of the 30-nt repeat unit. VCX/Y genes encode small and highly charged proteins containing putative bipartite nuclear localization signals. Although the exact function of this family member has yet to be determined, a role in mRNA stability regulation can be inferred from the ability of the highly similar family member, VCX-A, to inhibit mRNA decapping. A possible role in the regulation of ribosome assembly during spermatogenesis has also been suggested. [provided by RefSeq, Aug 2010] Expression Restricted expression toward testis (RPKM 26.5) See more Orthologs all
VCY, Official Symbol VCYprovided by HGNC Official Full Name variable charge Y-linkedprovided by HGNC Primary source HGNC:HGNC:12668 See related Ensembl:ENSG00000129864 MIM:400012; AllianceGenome:HGNC:12668 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPY1; VCY1; VCY1A Summary The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 20.6) See more
VCY1B, Official Symbol VCY1Bprovided by HGNC Official Full Name variable charge Y-linked 1Bprovided by HGNC Primary source HGNC:HGNC:31751 See related Ensembl:ENSG00000129862 MIM:400050; AllianceGenome:HGNC:31751 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPY1B Summary The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 20.7) See more
VDAC1, Official Symbol VDAC1provided by HGNC Official Full Name voltage dependent anion channel 1provided by HGNC Primary source HGNC:HGNC:12669 See related Ensembl:ENSG00000213585 MIM:604492; AllianceGenome:HGNC:12669 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PORIN; VDAC-1 Summary This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010] Expression Ubiquitous expression in heart (RPKM 107.1), duodenum (RPKM 94.9) and 25 other tissues See more Orthologs mouse all
VDAC1P11, Official Symbol VDAC1P11provided by HGNC Official Full Name voltage dependent anion channel 1 pseudogene 11provided by HGNC Primary source HGNC:HGNC:37480 See related AllianceGenome:HGNC:37480 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
VDAC1P12, Official Symbol VDAC1P12provided by HGNC Official Full Name voltage dependent anion channel 1 pseudogene 12provided by HGNC Primary source HGNC:HGNC:39680 See related AllianceGenome:HGNC:39680 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
VDAC1P13, Official Symbol VDAC1P13provided by HGNC Official Full Name voltage dependent anion channel 1 pseudogene 13provided by HGNC Primary source HGNC:HGNC:50515 See related Ensembl:ENSG00000232526 AllianceGenome:HGNC:50515 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
VDAC1P9, Official Symbol VDAC1P9provided by HGNC Official Full Name voltage dependent anion channel 1 pseudogene 9provided by HGNC Primary source HGNC:HGNC:37484 See related Ensembl:ENSG00000232366 AllianceGenome:HGNC:37484 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
VDAC2, Official Symbol VDAC2provided by HGNC Official Full Name voltage dependent anion channel 2provided by HGNC Primary source HGNC:HGNC:12672 See related Ensembl:ENSG00000165637 MIM:193245; AllianceGenome:HGNC:12672 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POR Summary This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Ubiquitous expression in heart (RPKM 81.3), esophagus (RPKM 66.2) and 25 other tissues See more Orthologs mouse all
VDAC2P1, Official Symbol VDAC2P1provided by HGNC Official Full Name VDAC2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:12673 See related AllianceGenome:HGNC:12673 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VDAC2P
VDAC2P4, Official Symbol VDAC2P4provided by HGNC Official Full Name VDAC2 pseudogene 4provided by HGNC Primary source HGNC:HGNC:51932 See related Ensembl:ENSG00000234682 AllianceGenome:HGNC:51932 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
VDAC3, Official Symbol VDAC3provided by HGNC Official Full Name voltage dependent anion channel 3provided by HGNC Primary source HGNC:HGNC:12674 See related Ensembl:ENSG00000078668 MIM:610029; AllianceGenome:HGNC:12674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VDAC-3; HD-VDAC3 Summary This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in heart (RPKM 97.4), testis (RPKM 53.6) and 25 other tissues See more Orthologs mouse all
VDAC3P1, Official Symbol VDAC3P1provided by HGNC Official Full Name voltage dependent anion channel 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:20722 See related AllianceGenome:HGNC:20722 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VDAC3P
VDR, Official Symbol VDRprovided by HGNC Official Full Name vitamin D receptorprovided by HGNC Primary source HGNC:HGNC:12679 See related Ensembl:ENSG00000111424 MIM:601769; AllianceGenome:HGNC:12679 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR1I1; PPP1R163 Summary This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018] Expression Broad expression in small intestine (RPKM 24.6), duodenum (RPKM 24.1) and 14 other tissues See more Orthologs mouse all
VEGFA, Official Symbol VEGFAprovided by HGNC Official Full Name vascular endothelial growth factor Aprovided by HGNC Primary source HGNC:HGNC:12680 See related Ensembl:ENSG00000112715 MIM:192240; AllianceGenome:HGNC:12680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VPF; VEGF; MVCD1; L-VEGF Summary This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Broad expression in thyroid (RPKM 146.9), prostate (RPKM 69.5) and 21 other tissues See more Orthologs mouse all
VEGFB, Official Symbol VEGFBprovided by HGNC Official Full Name vascular endothelial growth factor Bprovided by HGNC Primary source HGNC:HGNC:12681 See related Ensembl:ENSG00000173511 MIM:601398; AllianceGenome:HGNC:12681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VRF; VEGFL Summary This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011] Expression Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues See more Orthologs mouse all
VEGFC, Official Symbol VEGFCprovided by HGNC Official Full Name vascular endothelial growth factor Cprovided by HGNC Primary source HGNC:HGNC:12682 See related Ensembl:ENSG00000150630 MIM:601528; AllianceGenome:HGNC:12682 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VRP; Flt4-L; LMPH1D; LMPHM4 Summary The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014] Expression Broad expression in thyroid (RPKM 17.4), placenta (RPKM 7.1) and 21 other tissues See more Orthologs mouse all
VEGFD, Official Symbol VEGFDprovided by HGNC Official Full Name vascular endothelial growth factor Dprovided by HGNC Primary source HGNC:HGNC:3708 See related Ensembl:ENSG00000165197 MIM:300091; AllianceGenome:HGNC:3708 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIGF; VEGF-D Summary The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011] Expression Biased expression in lung (RPKM 21.7), fat (RPKM 4.7) and 9 other tissues See more Orthologs mouse all
VENTX, Official Symbol VENTXprovided by HGNC Official Full Name VENT homeoboxprovided by HGNC Primary source HGNC:HGNC:13639 See related Ensembl:ENSG00000151650 MIM:607158; AllianceGenome:HGNC:13639 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NA88A; HPX42B; VENTX2 Summary This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 1.9), spleen (RPKM 1.1) and 24 other tissues See more Orthologs mouse all
VENTXP1, Official Symbol VENTXP1provided by HGNC Official Full Name VENT homeobox pseudogene 1provided by HGNC Primary source HGNC:HGNC:30900 See related Ensembl:ENSG00000259849 AllianceGenome:HGNC:30900 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT18; NA88A; VENTX2P1 Summary Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the Vent homeobox gene family. [provided by RefSeq, Jul 2008]
VENTXP2, Official Symbol VENTXP2provided by HGNC Official Full Name VENT homeobox pseudogene 2provided by HGNC Primary source HGNC:HGNC:30901 See related Ensembl:ENSG00000215037 AllianceGenome:HGNC:30901 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the VENT homeobox gene family [provided by RefSeq, Mar 2013]
VEPH1, Official Symbol VEPH1provided by HGNC Official Full Name ventricular zone expressed PH domain containing 1provided by HGNC Primary source HGNC:HGNC:25735 See related Ensembl:ENSG00000197415 MIM:609594; AllianceGenome:HGNC:25735 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MELT; VEPH Summary Predicted to enable phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lung (RPKM 12.0), adrenal (RPKM 8.2) and 8 other tissues See more Orthologs mouse all
VEZF1, Official Symbol VEZF1provided by HGNC Official Full Name vascular endothelial zinc finger 1provided by HGNC Primary source HGNC:HGNC:12949 See related Ensembl:ENSG00000136451 MIM:606747; AllianceGenome:HGNC:12949 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DB1; CMD1OO; ZNF161 Summary Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008] Expression Ubiquitous expression in thyroid (RPKM 19.6), endometrium (RPKM 18.2) and 25 other tissues See more Orthologs mouse all