psui3905/ncbi_genes_summary huggingface dataset:
PRXL2AP1, Official Symbol PRXL2AP1provided by HGNC Official Full Name peroxiredoxin like 2A pseudogene 1provided by HGNC Primary source HGNC:HGNC:52407 See related Ensembl:ENSG00000257220 AllianceGenome:HGNC:52407 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM213AP1
PRXL2B, Official Symbol PRXL2Bprovided by HGNC Official Full Name peroxiredoxin like 2Bprovided by HGNC Primary source HGNC:HGNC:28390 See related Ensembl:ENSG00000157870 AllianceGenome:HGNC:28390 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1orf93; FAM213B Summary Predicted to enable antioxidant activity and prostaglandin-F synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 15.1), small intestine (RPKM 14.9) and 24 other tissues See more Orthologs mouse all
PRXL2C, Official Symbol PRXL2Cprovided by HGNC Official Full Name peroxiredoxin like 2Cprovided by HGNC Primary source HGNC:HGNC:16881 See related Ensembl:ENSG00000158122 AllianceGenome:HGNC:16881 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAED1; C9orf21 Summary Predicted to enable antioxidant activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.8), gall bladder (RPKM 7.6) and 25 other tissues See more Orthologs mouse all
PRXL2CP1, Official Symbol PRXL2CP1provided by HGNC Official Full Name PRXL2C pseudogene 1provided by HGNC Primary source HGNC:HGNC:54977 See related AllianceGenome:HGNC:54977 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRY, Official Symbol PRYprovided by HGNC Official Full Name PTPN13 like Y-linkedprovided by HGNC Primary source HGNC:HGNC:14024 See related Ensembl:ENSG00000169789 MIM:400019; AllianceGenome:HGNC:14024 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRY1; PTPN13LY Summary This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. It encodes a protein which has a low degree of similarity to protein tyrosine phosphatase, non-receptor type 13. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more telomeric copy. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more
PRY2, Official Symbol PRY2provided by HGNC Official Full Name PTPN13 like Y-linked 2provided by HGNC Primary source HGNC:HGNC:21504 See related Ensembl:ENSG00000169807 MIM:400041; AllianceGenome:HGNC:21504 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTPN13LY2 Summary This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. It encodes a protein which has a low degree of similarity to protein tyrosine phosphatase, non-receptor type 13. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more centromeric copy. [provided by RefSeq, Jul 2008]
PRYP1, Official Symbol PRYP1provided by HGNC Official Full Name PTPN13 like Y-linked pseudogene 1provided by HGNC Primary source HGNC:HGNC:34018 See related Ensembl:ENSG00000224166 AllianceGenome:HGNC:34018 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRY4P; PRYP7
PRYP2, Official Symbol PRYP2provided by HGNC Official Full Name PTPN13 like Y-linked pseudogene 2provided by HGNC Primary source HGNC:HGNC:34019 See related Ensembl:ENSG00000231311 AllianceGenome:HGNC:34019 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRYP3, Official Symbol PRYP3provided by HGNC Official Full Name PTPN13 like Y-linked pseudogene 3provided by HGNC Primary source HGNC:HGNC:34020 See related Ensembl:ENSG00000169763 AllianceGenome:HGNC:34020 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRYP4, Official Symbol PRYP4provided by HGNC Official Full Name PTPN13 like Y-linked pseudogene 4provided by HGNC Primary source HGNC:HGNC:34021 See related Ensembl:ENSG00000172283 AllianceGenome:HGNC:34021 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSAP, Official Symbol PSAPprovided by HGNC Official Full Name prosaposinprovided by HGNC Primary source HGNC:HGNC:9498 See related Ensembl:ENSG00000197746 MIM:176801; AllianceGenome:HGNC:9498 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLBA; SAP1; SAP2; PSAPD; PARK24 Summary This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] Annotation information Note: PSAP (Gene ID: 5660) and MTCH1 (Gene ID: 23787) share the PSAP symbol/alias in common. PSAP is a widely used alternative name for mitochondrial carrier 1 (MTCH1), which can be confused with the official symbol for PSAP (prosaposin, GeneID 5660). [01 Jun 2018] Expression Ubiquitous expression in spleen (RPKM 523.6), gall bladder (RPKM 491.5) and 25 other tissues See more Orthologs mouse all
PSAPL1, Official Symbol PSAPL1provided by HGNC Official Full Name prosaposin like 1provided by HGNC Primary source HGNC:HGNC:33131 See related Ensembl:ENSG00000178597 AllianceGenome:HGNC:33131 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that is related to the glycoprotein prosaposin. Based on sequence similarity between the encoded protein and prosaposin, it is predicted that the encoded protein is a preproprotein that is proteolytically processed to generate multiple protein products. These predicted products include saposins A-like, B-like, C-like, and D-like, which may play a role in the lysosomal degradation of sphingolipids. [provided by RefSeq, Jul 2015] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Orthologs mouse all
PSAT1, Official Symbol PSAT1provided by HGNC Official Full Name phosphoserine aminotransferase 1provided by HGNC Primary source HGNC:HGNC:19129 See related Ensembl:ENSG00000135069 MIM:610936; AllianceGenome:HGNC:19129 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSA; EPIP; NLS2; PSAT; PSATD Summary This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013] Expression Biased expression in brain (RPKM 69.9), liver (RPKM 61.3) and 13 other tissues See more Orthologs mouse all
PSAT1P2, Official Symbol PSAT1P2provided by HGNC Official Full Name phosphoserine aminotransferase 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:43988 See related AllianceGenome:HGNC:43988 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSAT1P3, Official Symbol PSAT1P3provided by HGNC Official Full Name phosphoserine aminotransferase 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:43989 See related Ensembl:ENSG00000230787 AllianceGenome:HGNC:43989 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSCA, Official Symbol PSCAprovided by HGNC Official Full Name prostate stem cell antigenprovided by HGNC Primary source HGNC:HGNC:9500 See related Ensembl:ENSG00000167653 MIM:602470; AllianceGenome:HGNC:9500 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRO232; lncPSCA Summary This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] Expression Biased expression in stomach (RPKM 721.2), urinary bladder (RPKM 108.9) and 1 other tissue See more Orthologs mouse all
PSD, Official Symbol PSDprovided by HGNC Official Full Name pleckstrin and Sec7 domain containingprovided by HGNC Primary source HGNC:HGNC:9507 See related Ensembl:ENSG00000059915 MIM:602327; AllianceGenome:HGNC:9507 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TYL; EFA6; PSD1; EFA6A Summary This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Biased expression in brain (RPKM 23.5), endometrium (RPKM 9.6) and 8 other tissues See more Orthologs mouse all
PSD2, Official Symbol PSD2provided by HGNC Official Full Name pleckstrin and Sec7 domain containing 2provided by HGNC Primary source HGNC:HGNC:19092 See related Ensembl:ENSG00000146005 AllianceGenome:HGNC:19092 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EFA6C Summary Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Predicted to be located in cleavage furrow and ruffle membrane. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 11.2) and testis (RPKM 0.5) See more Orthologs mouse all
PSD2-AS1, Official Symbol PSD2-AS1provided by HGNC Official Full Name PSD2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:52765 See related AllianceGenome:HGNC:52765 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 4.8) See more
PSD3, Official Symbol PSD3provided by HGNC Official Full Name pleckstrin and Sec7 domain containing 3provided by HGNC Primary source HGNC:HGNC:19093 See related Ensembl:ENSG00000156011 MIM:614440; AllianceGenome:HGNC:19093 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EFA6D; EFA6R; HCA67 Summary Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Predicted to be located in membrane. Predicted to be active in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 17.3), adrenal (RPKM 6.3) and 19 other tissues See more Orthologs mouse all
PSD4, Official Symbol PSD4provided by HGNC Official Full Name pleckstrin and Sec7 domain containing 4provided by HGNC Primary source HGNC:HGNC:19096 See related Ensembl:ENSG00000125637 MIM:614442; AllianceGenome:HGNC:19096 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIC; EFA6B Summary Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 21.5), spleen (RPKM 20.1) and 22 other tissues See more Orthologs mouse all
PSEN1, Official Symbol PSEN1provided by HGNC Official Full Name presenilin 1provided by HGNC Primary source HGNC:HGNC:9508 See related Ensembl:ENSG00000080815 MIM:104311; AllianceGenome:HGNC:9508 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD3; FAD; PS1; PS-1; S182; PSNL1; ACNINV3 Summary Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in colon (RPKM 14.6), small intestine (RPKM 14.0) and 25 other tissues See more Orthologs mouse all
PSEN2, Official Symbol PSEN2provided by HGNC Official Full Name presenilin 2provided by HGNC Primary source HGNC:HGNC:9509 See related Ensembl:ENSG00000143801 MIM:600759; AllianceGenome:HGNC:9509 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD4; PS2; AD3L; STM2; CMD1V Summary Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 4.6), prostate (RPKM 4.4) and 25 other tissues See more Orthologs mouse all
PSENEN, Official Symbol PSENENprovided by HGNC Official Full Name presenilin enhancer, gamma-secretase subunitprovided by HGNC Primary source HGNC:HGNC:30100 See related Ensembl:ENSG00000205155 MIM:607632; AllianceGenome:HGNC:30100 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PEN2; PEN-2; MDS033; ACNINV2; MSTP064 Summary Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in testis (RPKM 43.8), lung (RPKM 19.9) and 25 other tissues See more Orthologs mouse all
PSG1, Official Symbol PSG1provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 1provided by HGNC Primary source HGNC:HGNC:9514 See related Ensembl:ENSG00000231924 MIM:176390; AllianceGenome:HGNC:9514 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1 Summary The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009] Expression Restricted expression toward placenta (RPKM 224.3) See more
PSG11, Official Symbol PSG11provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 11provided by HGNC Primary source HGNC:HGNC:9516 See related Ensembl:ENSG00000243130 MIM:176401; AllianceGenome:HGNC:9516 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSG13; PSG14; PSBG-11; PSBG-13 Summary The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] Expression Restricted expression toward placenta (RPKM 77.7) See more
PSG2, Official Symbol PSG2provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 2provided by HGNC Primary source HGNC:HGNC:9519 See related Ensembl:ENSG00000242221 MIM:176391; AllianceGenome:HGNC:9519 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEA; PSG1; PSBG2 Summary The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] Expression Restricted expression toward placenta (RPKM 263.6) See more Orthologs all
PSG3, Official Symbol PSG3provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 3provided by HGNC Primary source HGNC:HGNC:9520 See related Ensembl:ENSG00000221826 MIM:176392; AllianceGenome:HGNC:9520 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] Expression Restricted expression toward placenta (RPKM 164.7) See more
PSG4, Official Symbol PSG4provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 4provided by HGNC Primary source HGNC:HGNC:9521 See related Ensembl:ENSG00000243137 MIM:176393; AllianceGenome:HGNC:9521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSG9; PSBG-4; PSBG-9 Summary The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Restricted expression toward placenta (RPKM 137.5) See more Orthologs all
PSG5, Official Symbol PSG5provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 5provided by HGNC Primary source HGNC:HGNC:9522 See related Ensembl:ENSG00000204941 MIM:176394; AllianceGenome:HGNC:9522 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSG; FL-NCA-3 Summary The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] Expression Restricted expression toward placenta (RPKM 117.8) See more
PSG6, Official Symbol PSG6provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 6provided by HGNC Primary source HGNC:HGNC:9523 See related Ensembl:ENSG00000170848 MIM:176395; AllianceGenome:HGNC:9523 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSG10; PSGGB; PSBG-6; PSBG-10; PSBG-12 Summary This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012] Expression Restricted expression toward placenta (RPKM 62.8) See more
PSG7, Official Symbol PSG7provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 7provided by HGNC Primary source HGNC:HGNC:9524 See related Ensembl:ENSG00000221878 MIM:176396; AllianceGenome:HGNC:9524 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSG1; PSGGA; PSBG-7; PS-beta-G-7 Summary This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Restricted expression toward placenta (RPKM 24.2) See more Orthologs all
PSG8, Official Symbol PSG8provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 8provided by HGNC Primary source HGNC:HGNC:9525 See related Ensembl:ENSG00000124467 MIM:176397; AllianceGenome:HGNC:9525 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSG1 Summary The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] Expression Restricted expression toward placenta (RPKM 46.5) See more
PSG8-AS1, Official Symbol PSG8-AS1provided by HGNC Official Full Name PSG8 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:52550 See related Ensembl:ENSG00000225877 AllianceGenome:HGNC:52550 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PSG9, Official Symbol PSG9provided by HGNC Official Full Name pregnancy specific beta-1-glycoprotein 9provided by HGNC Primary source HGNC:HGNC:9526 See related Ensembl:ENSG00000183668 MIM:176398; AllianceGenome:HGNC:9526 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PS34; PSG11; PSGII; PSBG-9; PSBG-11 Summary The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014] Expression Restricted expression toward placenta (RPKM 51.2) See more Orthologs all
PSIP1, Official Symbol PSIP1provided by HGNC Official Full Name PC4 and SRSF1 interacting protein 1provided by HGNC Primary source HGNC:HGNC:9527 See related Ensembl:ENSG00000164985 MIM:603620; AllianceGenome:HGNC:9527 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p52; p75; PAIP; DFS70; LEDGF; PSIP2 Summary Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 41.2), ovary (RPKM 33.4) and 24 other tissues See more Orthologs mouse all
PSKH1, Official Symbol PSKH1provided by HGNC Official Full Name protein serine kinase H1provided by HGNC Primary source HGNC:HGNC:9529 See related Ensembl:ENSG00000159792 MIM:177015; AllianceGenome:HGNC:9529 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable protein kinase activity. Predicted to act upstream of or within determination of left/right symmetry; heart development; and protein phosphorylation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 16.5), ovary (RPKM 12.3) and 25 other tissues See more Orthologs mouse all
PSKH2, Official Symbol PSKH2provided by HGNC Official Full Name protein serine kinase H2provided by HGNC Primary source HGNC:HGNC:18997 See related Ensembl:ENSG00000147613 MIM:620394; AllianceGenome:HGNC:18997 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PSMA1, Official Symbol PSMA1provided by HGNC Official Full Name proteasome 20S subunit alpha 1provided by HGNC Primary source HGNC:HGNC:9530 See related Ensembl:ENSG00000129084 MIM:602854; AllianceGenome:HGNC:9530 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NU; HC2; PROS30; HEL-S-275 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009] Expression Ubiquitous expression in appendix (RPKM 35.7), placenta (RPKM 35.1) and 25 other tissues See more Orthologs mouse all
PSMA2, Official Symbol PSMA2provided by HGNC Official Full Name proteasome 20S subunit alpha 2provided by HGNC Primary source HGNC:HGNC:9531 See related Ensembl:ENSG00000106588 MIM:176842; AllianceGenome:HGNC:9531 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MU; HC3; PSC2; PMSA2 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 64.0), fat (RPKM 48.4) and 25 other tissues See more Orthologs mouse all
PSMA2P3, Official Symbol PSMA2P3provided by HGNC Official Full Name proteasome subunit alpha 2 pseudogene 3provided by HGNC Primary source HGNC:HGNC:43834 See related Ensembl:ENSG00000227890 AllianceGenome:HGNC:43834 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSMA2L
PSMA3, Official Symbol PSMA3provided by HGNC Official Full Name proteasome 20S subunit alpha 3provided by HGNC Primary source HGNC:HGNC:9532 See related Ensembl:ENSG00000100567 MIM:176843; AllianceGenome:HGNC:9532 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC8; PSC3 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in appendix (RPKM 46.2), lymph node (RPKM 44.1) and 25 other tissues See more Orthologs mouse all
PSMA3-AS1, Official Symbol PSMA3-AS1provided by HGNC Official Full Name PSMA3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:26445 See related Ensembl:ENSG00000257621 AllianceGenome:HGNC:26445 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in lymph node (RPKM 21.4), spleen (RPKM 19.8) and 25 other tissues See more
PSMA4, Official Symbol PSMA4provided by HGNC Official Full Name proteasome 20S subunit alpha 4provided by HGNC Primary source HGNC:HGNC:9533 See related Ensembl:ENSG00000041357 MIM:176846; AllianceGenome:HGNC:9533 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC9; PSC9; HsT17706 Summary This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016] Expression Ubiquitous expression in appendix (RPKM 63.8), lymph node (RPKM 63.8) and 25 other tissues See more Orthologs mouse all
PSMA5, Official Symbol PSMA5provided by HGNC Official Full Name proteasome 20S subunit alpha 5provided by HGNC Primary source HGNC:HGNC:9534 See related Ensembl:ENSG00000143106 MIM:176844; AllianceGenome:HGNC:9534 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSC5; ZETA Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in lymph node (RPKM 14.6), appendix (RPKM 13.2) and 25 other tissues See more Orthologs mouse all
PSMA5P1, Official Symbol PSMA5P1provided by HGNC Official Full Name PSMA5 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54966 See related Ensembl:ENSG00000235136 AllianceGenome:HGNC:54966 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMA6, Official Symbol PSMA6provided by HGNC Official Full Name proteasome 20S subunit alpha 6provided by HGNC Primary source HGNC:HGNC:9535 See related Ensembl:ENSG00000100902 MIM:602855; AllianceGenome:HGNC:9535 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IOTA; p27K; PROS27 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in testis (RPKM 34.7), colon (RPKM 23.0) and 25 other tissues See more Orthologs mouse all
PSMA6P3, Official Symbol PSMA6P3provided by HGNC Official Full Name proteasome subunit alpha 6 pseudogene 3provided by HGNC Primary source HGNC:HGNC:39608 See related Ensembl:ENSG00000233767 AllianceGenome:HGNC:39608 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMA7, Official Symbol PSMA7provided by HGNC Official Full Name proteasome 20S subunit alpha 7provided by HGNC Primary source HGNC:HGNC:9536 See related Ensembl:ENSG00000101182 MIM:606607; AllianceGenome:HGNC:9536 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6; HSPC; RC6-1; XAPC7; HEL-S-276 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in fat (RPKM 92.5), appendix (RPKM 63.9) and 25 other tissues See more Orthologs mouse all
PSMA8, Official Symbol PSMA8provided by HGNC Official Full Name proteasome 20S subunit alpha 8provided by HGNC Primary source HGNC:HGNC:22985 See related Ensembl:ENSG00000154611 MIM:617841; AllianceGenome:HGNC:22985 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSMA7L Summary Predicted to be involved in meiotic cell cycle and proteasomal protein catabolic process. Located in extracellular exosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 11.3) See more Orthologs mouse all
PSMB1, Official Symbol PSMB1provided by HGNC Official Full Name proteasome 20S subunit beta 1provided by HGNC Primary source HGNC:HGNC:9537 See related Ensembl:ENSG00000008018 MIM:602017; AllianceGenome:HGNC:9537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC5; PSC5; PMSB1; NEDMHAL Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 83.1), fat (RPKM 75.6) and 25 other tissues See more Orthologs mouse all