psui3905/ncbi_genes_summary huggingface dataset:
MAPK10-AS1, Official Symbol MAPK10-AS1provided by HGNC Official Full Name MAPK10 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40359 See related Ensembl:ENSG00000250062 AllianceGenome:HGNC:40359 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 3.4) See more
MAPK11, Official Symbol MAPK11provided by HGNC Official Full Name mitogen-activated protein kinase 11provided by HGNC Primary source HGNC:HGNC:6873 See related Ensembl:ENSG00000185386 MIM:602898; AllianceGenome:HGNC:6873 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2 Summary This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in fat (RPKM 13.9), brain (RPKM 10.1) and 22 other tissues See more Orthologs mouse all
MAPK12, Official Symbol MAPK12provided by HGNC Official Full Name mitogen-activated protein kinase 12provided by HGNC Primary source HGNC:HGNC:6874 See related Ensembl:ENSG00000188130 MIM:602399; AllianceGenome:HGNC:6874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA Summary Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 6.0), prostate (RPKM 5.7) and 24 other tissues See more Orthologs mouse all
MAPK13, Official Symbol MAPK13provided by HGNC Official Full Name mitogen-activated protein kinase 13provided by HGNC Primary source HGNC:HGNC:6875 See related Ensembl:ENSG00000156711 MIM:602899; AllianceGenome:HGNC:6875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta Summary This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Broad expression in skin (RPKM 21.7), small intestine (RPKM 17.1) and 22 other tissues See more Orthologs mouse all
MAPK14, Official Symbol MAPK14provided by HGNC Official Full Name mitogen-activated protein kinase 14provided by HGNC Primary source HGNC:HGNC:6876 See related Ensembl:ENSG00000112062 MIM:600289; AllianceGenome:HGNC:6876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 18.5), placenta (RPKM 11.7) and 25 other tissues See more Orthologs mouse all
MAPK15, Official Symbol MAPK15provided by HGNC Official Full Name mitogen-activated protein kinase 15provided by HGNC Primary source HGNC:HGNC:24667 See related Ensembl:ENSG00000181085 MIM:618616; AllianceGenome:HGNC:24667 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERK7; ERK8 Summary Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues See more Orthologs mouse all
MAPK1IP1L, Official Symbol MAPK1IP1Lprovided by HGNC Official Full Name mitogen-activated protein kinase 1 interacting protein 1 likeprovided by HGNC Primary source HGNC:HGNC:19840 See related Ensembl:ENSG00000168175 MIM:617226; AllianceGenome:HGNC:19840 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MISS; C14orf32; c14_5346 Expression Ubiquitous expression in bone marrow (RPKM 15.9), kidney (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
MAPK3, Official Symbol MAPK3provided by HGNC Official Full Name mitogen-activated protein kinase 3provided by HGNC Primary source HGNC:HGNC:6877 See related Ensembl:ENSG00000102882 MIM:601795; AllianceGenome:HGNC:6877 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in small intestine (RPKM 45.8), colon (RPKM 42.8) and 25 other tissues See more Orthologs mouse all
MAPK4, Official Symbol MAPK4provided by HGNC Official Full Name mitogen-activated protein kinase 4provided by HGNC Primary source HGNC:HGNC:6878 See related Ensembl:ENSG00000141639 MIM:176949; AllianceGenome:HGNC:6878 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERK4; ERK-4; PRKM4; p63MAPK; p63-MAPK Summary Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Biased expression in adrenal (RPKM 3.2), brain (RPKM 3.1) and 11 other tissues See more Orthologs mouse all
MAPK6, Official Symbol MAPK6provided by HGNC Official Full Name mitogen-activated protein kinase 6provided by HGNC Primary source HGNC:HGNC:6879 See related Ensembl:ENSG00000069956 MIM:602904; AllianceGenome:HGNC:6879 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERK3; PRKM6; p97MAPK; HsT17250 Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 25.2), brain (RPKM 20.8) and 25 other tissues See more Orthologs mouse all
MAPK6-DT, Official Symbol MAPK6-DTprovided by HGNC Official Full Name MAPK6 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53900 See related Ensembl:ENSG00000259438 AllianceGenome:HGNC:53900 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as lncMAPK6
MAPK6P1, Official Symbol MAPK6P1provided by HGNC Official Full Name mitogen-activated protein kinase 6 pseudogene 1provided by HGNC Primary source HGNC:HGNC:18980 See related AllianceGenome:HGNC:18980 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Erk3ps1; MAPK6PS1
MAPK6P4, Official Symbol MAPK6P4provided by HGNC Official Full Name mitogen-activated protein kinase 6 pseudogene 4provided by HGNC Primary source HGNC:HGNC:18456 See related AllianceGenome:HGNC:18456 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Erk3ps4; MAPK6PS4
MAPK6P5, Official Symbol MAPK6P5provided by HGNC Official Full Name mitogen-activated protein kinase 6 pseudogene 5provided by HGNC Primary source HGNC:HGNC:18979 See related AllianceGenome:HGNC:18979 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAPK6PS5
MAPK6P6, Official Symbol MAPK6P6provided by HGNC Official Full Name mitogen-activated protein kinase 6 pseudogene 6provided by HGNC Primary source HGNC:HGNC:18978 See related AllianceGenome:HGNC:18978 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAPK6PS6
MAPK7, Official Symbol MAPK7provided by HGNC Official Full Name mitogen-activated protein kinase 7provided by HGNC Primary source HGNC:HGNC:6880 See related Ensembl:ENSG00000166484 MIM:602521; AllianceGenome:HGNC:6880 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BMK1; ERK4; ERK5; PRKM7 Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
MAPK8, Official Symbol MAPK8provided by HGNC Official Full Name mitogen-activated protein kinase 8provided by HGNC Primary source HGNC:HGNC:6881 See related Ensembl:ENSG00000107643 MIM:601158; AllianceGenome:HGNC:6881 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2 Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in brain (RPKM 9.4), thyroid (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
MAPK8IP1, Official Symbol MAPK8IP1provided by HGNC Official Full Name mitogen-activated protein kinase 8 interacting protein 1provided by HGNC Primary source HGNC:HGNC:6882 See related Ensembl:ENSG00000121653 MIM:604641; AllianceGenome:HGNC:6882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IB1; JIP1; JIP-1; PRKM8IP Summary This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011] Expression Biased expression in brain (RPKM 54.8), testis (RPKM 11.7) and 5 other tissues See more Orthologs mouse all
MAPK8IP1P1, Official Symbol MAPK8IP1P1provided by HGNC Official Full Name mitogen-activated protein kinase 8 interacting protein 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:6885 See related Ensembl:ENSG00000262500 AllianceGenome:HGNC:6885 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAPK8IPP; PRKM8IPP
MAPK8IP1P2, Official Symbol MAPK8IP1P2provided by HGNC Official Full Name mitogen-activated protein kinase 8 interacting protein 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:52402 See related AllianceGenome:HGNC:52402 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MAPK8IP2, Official Symbol MAPK8IP2provided by HGNC Official Full Name mitogen-activated protein kinase 8 interacting protein 2provided by HGNC Primary source HGNC:HGNC:6883 See related Ensembl:ENSG00000008735 MIM:607755; AllianceGenome:HGNC:6883 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IB2; IB-2; JIP2; PRKM8IPL Summary This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017] Expression Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues See more Orthologs mouse all
MAPK8IP3, Official Symbol MAPK8IP3provided by HGNC Official Full Name mitogen-activated protein kinase 8 interacting protein 3provided by HGNC Primary source HGNC:HGNC:6884 See related Ensembl:ENSG00000138834 MIM:605431; AllianceGenome:HGNC:6884 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as syd; JIP3; SYD2; JIP-3; JSAP1; NEDBA Summary The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 22.4), spleen (RPKM 12.7) and 24 other tissues See more Orthologs mouse all
MAPK9, Official Symbol MAPK9provided by HGNC Official Full Name mitogen-activated protein kinase 9provided by HGNC Primary source HGNC:HGNC:6886 See related Ensembl:ENSG00000050748 MIM:602896; AllianceGenome:HGNC:6886 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in brain (RPKM 22.1), thyroid (RPKM 10.2) and 25 other tissues See more Orthologs mouse all
MAPKAP1, Official Symbol MAPKAP1provided by HGNC Official Full Name MAPK associated protein 1provided by HGNC Primary source HGNC:HGNC:18752 See related Ensembl:ENSG00000119487 MIM:610558; AllianceGenome:HGNC:18752 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIP1; SIN1; JC310; SIN1b; SIN1g Summary This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 18.8), testis (RPKM 17.4) and 25 other tissues See more Orthologs mouse all
MAPKAPK2, Official Symbol MAPKAPK2provided by HGNC Official Full Name MAPK activated protein kinase 2provided by HGNC Primary source HGNC:HGNC:6887 See related Ensembl:ENSG00000162889 MIM:602006; AllianceGenome:HGNC:6887 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MK2; MK-2; MAPKAP-K2 Summary This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 54.9), heart (RPKM 45.1) and 25 other tissues See more Orthologs mouse all
MAPKAPK3, Official Symbol MAPKAPK3provided by HGNC Official Full Name MAPK activated protein kinase 3provided by HGNC Primary source HGNC:HGNC:6888 See related Ensembl:ENSG00000114738 MIM:602130; AllianceGenome:HGNC:6888 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 3PK; MK3; MK-3; MDPT3; MAPKAP3; MAPKAP-K3; MAPKAPK-3 Summary This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Expression Broad expression in heart (RPKM 55.1), bone marrow (RPKM 29.6) and 25 other tissues See more Orthologs mouse all
MAPKAPK5, Official Symbol MAPKAPK5provided by HGNC Official Full Name MAPK activated protein kinase 5provided by HGNC Primary source HGNC:HGNC:6889 See related Ensembl:ENSG00000089022 MIM:606723; AllianceGenome:HGNC:6889 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MK5; MK-5; NCFD; PRAK; MAPKAP-K5 Summary The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012] Expression Ubiquitous expression in small intestine (RPKM 3.1), colon (RPKM 2.9) and 25 other tissues See more Orthologs mouse all
MAPKAPK5-AS1, Official Symbol MAPKAPK5-AS1provided by HGNC Official Full Name MAPKAPK5 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:24091 See related Ensembl:ENSG00000234608 AllianceGenome:HGNC:24091 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAAS; C12orf47 Expression Ubiquitous expression in colon (RPKM 6.8), lymph node (RPKM 5.9) and 25 other tissues See more
MAPKAPK5P1, Official Symbol MAPKAPK5P1provided by HGNC Official Full Name MAPKAPK5 pseudogene 1provided by HGNC Primary source HGNC:HGNC:45246 See related Ensembl:ENSG00000224498 AllianceGenome:HGNC:45246 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MAPKBP1, Official Symbol MAPKBP1provided by HGNC Official Full Name mitogen-activated protein kinase binding protein 1provided by HGNC Primary source HGNC:HGNC:29536 See related Ensembl:ENSG00000137802 MIM:616786; AllianceGenome:HGNC:29536 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JNKBP1; NPHP20; JNKBP-1 Summary This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017] Expression Broad expression in testis (RPKM 16.2), skin (RPKM 11.0) and 23 other tissues See more Orthologs mouse all
MAPRE1, Official Symbol MAPRE1provided by HGNC Official Full Name microtubule associated protein RP/EB family member 1provided by HGNC Primary source HGNC:HGNC:6890 See related Ensembl:ENSG00000101367 MIM:603108; AllianceGenome:HGNC:6890 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EB1 Summary The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 71.1), thyroid (RPKM 48.1) and 25 other tissues See more Orthologs mouse all
MAPRE1P3, Official Symbol MAPRE1P3provided by HGNC Official Full Name MAPRE1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:37762 See related Ensembl:ENSG00000233204 AllianceGenome:HGNC:37762 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MAPRE2, Official Symbol MAPRE2provided by HGNC Official Full Name microtubule associated protein RP/EB family member 2provided by HGNC Primary source HGNC:HGNC:6891 See related Ensembl:ENSG00000166974 MIM:605789; AllianceGenome:HGNC:6891 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EB1; EB2; RP1; CSCSC2 Summary The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in brain (RPKM 59.8), heart (RPKM 31.4) and 24 other tissues See more Orthologs mouse all
MAPRE3, Official Symbol MAPRE3provided by HGNC Official Full Name microtubule associated protein RP/EB family member 3provided by HGNC Primary source HGNC:HGNC:6892 See related Ensembl:ENSG00000084764 MIM:605788; AllianceGenome:HGNC:6892 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EB3; RP3; EBF3; EBF3-S Summary The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 45.3), testis (RPKM 13.7) and 20 other tissues See more Orthologs mouse all
MAPRE3-AS1, Official Symbol MAPRE3-AS1provided by HGNC Official Full Name MAPRE3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40362 See related Ensembl:ENSG00000205500 AllianceGenome:HGNC:40362 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MAPT, Official Symbol MAPTprovided by HGNC Official Full Name microtubule associated protein tauprovided by HGNC Primary source HGNC:HGNC:6893 See related Ensembl:ENSG00000186868 MIM:157140; AllianceGenome:HGNC:6893 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6 Summary This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 70.2), kidney (RPKM 12.0) and 2 other tissues See more Orthologs mouse all
MAPT-IT1, Official Symbol MAPT-IT1provided by HGNC Official Full Name MAPT intronic transcript 1provided by HGNC Primary source HGNC:HGNC:43741 See related Ensembl:ENSG00000279685 AllianceGenome:HGNC:43741 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MARCHF1, Official Symbol MARCHF1provided by HGNC Official Full Name membrane associated ring-CH-type finger 1provided by HGNC Primary source HGNC:HGNC:26077 See related Ensembl:ENSG00000145416 MIM:613331; AllianceGenome:HGNC:26077 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH1; RNF171; MARCH-I Summary MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010] Expression Broad expression in lymph node (RPKM 10.3), spleen (RPKM 8.7) and 21 other tissues See more Orthologs mouse all
MARCHF10, Official Symbol MARCHF10provided by HGNC Official Full Name membrane associated ring-CH-type finger 10provided by HGNC Primary source HGNC:HGNC:26655 See related Ensembl:ENSG00000173838 MIM:613337; AllianceGenome:HGNC:26655 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF190; MARCH-X; MARCH10 Summary MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010] Expression Restricted expression toward testis (RPKM 20.7) See more Orthologs mouse all
MARCHF10-DT, Official Symbol MARCHF10-DTprovided by HGNC Official Full Name MARCHF10 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:52815 See related Ensembl:ENSG00000265000 AllianceGenome:HGNC:52815 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH10-DT Expression Low expression observed in reference dataset See more
MARCHF11, Official Symbol MARCHF11provided by HGNC Official Full Name membrane associated ring-CH-type finger 11provided by HGNC Primary source HGNC:HGNC:33609 See related Ensembl:ENSG00000183654 MIM:613338; AllianceGenome:HGNC:33609 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF226; MARCH11; MARCH-XI Summary MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010] Expression Restricted expression toward testis (RPKM 20.4) See more Orthologs mouse all
MARCHF11-AS1, Official Symbol MARCHF11-AS1provided by HGNC Official Full Name MARCHF11 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41287 See related Ensembl:ENSG00000250981 AllianceGenome:HGNC:41287 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH11-AS1 Expression Low expression observed in reference dataset See more
MARCHF2, Official Symbol MARCHF2provided by HGNC Official Full Name membrane associated ring-CH-type finger 2provided by HGNC Primary source HGNC:HGNC:28038 See related Ensembl:ENSG00000099785 MIM:613332; AllianceGenome:HGNC:28038 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH2; RNF172; HSPC240; MARCH-II Summary MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010] Expression Ubiquitous expression in fat (RPKM 20.9), heart (RPKM 12.9) and 25 other tissues See more Orthologs mouse all
MARCHF3, Official Symbol MARCHF3provided by HGNC Official Full Name membrane associated ring-CH-type finger 3provided by HGNC Primary source HGNC:HGNC:28728 See related Ensembl:ENSG00000173926 MIM:613333; AllianceGenome:HGNC:28728 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH3; RNF173; MARCH-III Summary This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013] Expression Broad expression in testis (RPKM 2.7), heart (RPKM 1.5) and 22 other tissues See more Orthologs mouse all
MARCHF4, Official Symbol MARCHF4provided by HGNC Official Full Name membrane associated ring-CH-type finger 4provided by HGNC Primary source HGNC:HGNC:29269 See related Ensembl:ENSG00000144583 MIM:608208; AllianceGenome:HGNC:29269 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH4; RNF174; MARCH-IV Summary MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010] Expression Biased expression in brain (RPKM 3.9), stomach (RPKM 1.1) and 2 other tissues See more Orthologs mouse all
MARCHF6, Official Symbol MARCHF6provided by HGNC Official Full Name membrane associated ring-CH-type finger 6provided by HGNC Primary source HGNC:HGNC:30550 See related Ensembl:ENSG00000145495 MIM:613297; AllianceGenome:HGNC:30550 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEB4; DOA10; FAME3; FCMTE3; MARCH6; RNF176; MARCH-VI Summary This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in brain (RPKM 18.9), bone marrow (RPKM 17.4) and 25 other tissues See more Orthologs mouse all
MARCHF7, Official Symbol MARCHF7provided by HGNC Official Full Name membrane associated ring-CH-type finger 7provided by HGNC Primary source HGNC:HGNC:17393 See related Ensembl:ENSG00000136536 MIM:613334; AllianceGenome:HGNC:17393 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AXO; AXOT; MARCH7; RNF177; MARCH-VII Summary MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010] Expression Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 28.8) and 25 other tissues See more Orthologs mouse all
MARCHF8, Official Symbol MARCHF8provided by HGNC Official Full Name membrane associated ring-CH-type finger 8provided by HGNC Primary source HGNC:HGNC:23356 See related Ensembl:ENSG00000165406 MIM:613335; AllianceGenome:HGNC:23356 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIR; CMIR; c-MIR; MARCH8; RNF178; MARCH-VIII Summary MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010] Expression Ubiquitous expression in testis (RPKM 18.4), bone marrow (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
MARCHF9, Official Symbol MARCHF9provided by HGNC Official Full Name membrane associated ring-CH-type finger 9provided by HGNC Primary source HGNC:HGNC:25139 See related Ensembl:ENSG00000139266 MIM:613336; AllianceGenome:HGNC:25139 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARCH9; RNF179; MARCH-IX Summary MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010] Expression Ubiquitous expression in kidney (RPKM 5.4), spleen (RPKM 4.4) and 25 other tissues See more Orthologs mouse all
MARCKS, Official Symbol MARCKSprovided by HGNC Official Full Name myristoylated alanine rich protein kinase C substrateprovided by HGNC Primary source HGNC:HGNC:6759 See related Ensembl:ENSG00000277443 MIM:177061; AllianceGenome:HGNC:6759 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MACS; 80K-L; PKCSL; PRKCSL Summary The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 86.0), colon (RPKM 50.6) and 25 other tissues See more Orthologs mouse all