psui3905/ncbi_genes_summary huggingface dataset:
PANK2-AS1, Official Symbol PANK2-AS1provided by HGNC Official Full Name PANK2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40732 See related AllianceGenome:HGNC:40732 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PANK3, Official Symbol PANK3provided by HGNC Official Full Name pantothenate kinase 3provided by HGNC Primary source HGNC:HGNC:19365 See related Ensembl:ENSG00000120137 MIM:606161; AllianceGenome:HGNC:19365 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 27.0), colon (RPKM 21.4) and 25 other tissues See more Orthologs mouse all
PANK4, Official Symbol PANK4provided by HGNC Official Full Name pantothenate kinase 4 (inactive)provided by HGNC Primary source HGNC:HGNC:19366 See related Ensembl:ENSG00000157881 MIM:606162; AllianceGenome:HGNC:19366 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTRCT49 Summary This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 4.0), heart (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
PANO1, Official Symbol PANO1provided by HGNC Official Full Name proapoptotic nucleolar protein 1provided by HGNC Primary source HGNC:HGNC:51237 See related Ensembl:ENSG00000288675 AllianceGenome:HGNC:51237 Gene type protein coding RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PANO Summary Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of apoptotic process; and regulation of protein stability. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
PANTR1, Official Symbol PANTR1provided by HGNC Official Full Name POU3F3 adjacent non-coding transcript 1provided by HGNC Primary source HGNC:HGNC:49513 See related Ensembl:ENSG00000233639 MIM:618169; AllianceGenome:HGNC:49513 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01158; linc-Brn1a; linc-POU3F3 Summary Predicted to act upstream of or within regulation of gene expression. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 2.2) and kidney (RPKM 1.6) See more Orthologs mouse all
PANX1, Official Symbol PANX1provided by HGNC Official Full Name pannexin 1provided by HGNC Primary source HGNC:HGNC:8599 See related Ensembl:ENSG00000110218 MIM:608420; AllianceGenome:HGNC:8599 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PX1; MRS1; OOMD7; OZEMA7; UNQ2529 Summary The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 7.4), appendix (RPKM 5.7) and 25 other tissues See more Orthologs mouse all
PANX2, Official Symbol PANX2provided by HGNC Official Full Name pannexin 2provided by HGNC Primary source HGNC:HGNC:8600 See related Ensembl:ENSG00000073150 MIM:608421; AllianceGenome:HGNC:8600 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PX2; hPANX2 Summary The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] Expression Broad expression in brain (RPKM 3.4), kidney (RPKM 1.1) and 16 other tissues See more Orthologs mouse all
PANX3, Official Symbol PANX3provided by HGNC Official Full Name pannexin 3provided by HGNC Primary source HGNC:HGNC:20573 See related Ensembl:ENSG00000154143 MIM:608422; AllianceGenome:HGNC:20573 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PX3 Summary The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
PAOX, Official Symbol PAOXprovided by HGNC Official Full Name polyamine oxidaseprovided by HGNC Primary source HGNC:HGNC:20837 See related Ensembl:ENSG00000148832 MIM:615853; AllianceGenome:HGNC:20837 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAO Summary Enables polyamine oxidase activity. Involved in polyamine metabolic process and positive regulation of spermidine biosynthetic process. Predicted to be located in cytosol and peroxisomal matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 17.7), spleen (RPKM 4.1) and 20 other tissues See more Orthologs mouse all
PAPLN, Official Symbol PAPLNprovided by HGNC Official Full Name papilin, proteoglycan like sulfated glycoproteinprovided by HGNC Primary source HGNC:HGNC:19262 See related Ensembl:ENSG00000100767 MIM:617785; AllianceGenome:HGNC:19262 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPN Summary Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 9.2), kidney (RPKM 8.9) and 22 other tissues See more Orthologs mouse all
PAPOLA, Official Symbol PAPOLAprovided by HGNC Official Full Name poly(A) polymerase alphaprovided by HGNC Primary source HGNC:HGNC:14981 See related Ensembl:ENSG00000090060 MIM:605553; AllianceGenome:HGNC:14981 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAP; PAP-alpha Summary The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in testis (RPKM 27.7), thyroid (RPKM 22.4) and 25 other tissues See more Orthologs mouse all
PAPOLA-DT, Official Symbol PAPOLA-DTprovided by HGNC Official Full Name PAPOLA divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55380 See related AllianceGenome:HGNC:55380 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PAPOLB, Official Symbol PAPOLBprovided by HGNC Official Full Name poly(A) polymerase betaprovided by HGNC Primary source HGNC:HGNC:15970 See related Ensembl:ENSG00000218823 MIM:607436; AllianceGenome:HGNC:15970 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAPT; TPAP Summary Predicted to enable polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
PAPOLG, Official Symbol PAPOLGprovided by HGNC Official Full Name poly(A) polymerase gammaprovided by HGNC Primary source HGNC:HGNC:14982 See related Ensembl:ENSG00000115421 MIM:616865; AllianceGenome:HGNC:14982 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 5.8), testis (RPKM 3.7) and 25 other tissues See more Orthologs mouse all
PAPPA, Official Symbol PAPPAprovided by HGNC Official Full Name pappalysin 1provided by HGNC Primary source HGNC:HGNC:8602 See related Ensembl:ENSG00000182752 MIM:176385; AllianceGenome:HGNC:8602 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase Summary This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017] Expression Biased expression in placenta (RPKM 34.5) and kidney (RPKM 1.5) See more Orthologs mouse all
PAPPA-AS1, Official Symbol PAPPA-AS1provided by HGNC Official Full Name PAPPA antisense RNA 1provided by HGNC Primary source HGNC:HGNC:35152 See related Ensembl:ENSG00000256040 MIM:610689; AllianceGenome:HGNC:35152 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIPAS; TAF4B; PAPPAS; TAF2C2; PAPPAAS; PAPPA-AS; TAFII105; NCRNA00156 Summary Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
PAPPA2, Official Symbol PAPPA2provided by HGNC Official Full Name pappalysin 2provided by HGNC Primary source HGNC:HGNC:14615 See related Ensembl:ENSG00000116183 MIM:619485; AllianceGenome:HGNC:14615 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SSDA; PAPPE; PLAC3; PAPP-E; PAPP-A2 Summary This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] Expression Biased expression in placenta (RPKM 23.7), kidney (RPKM 2.2) and 1 other tissue See more Orthologs mouse all
PAPSS1, Official Symbol PAPSS1provided by HGNC Official Full Name 3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by HGNC Primary source HGNC:HGNC:8603 See related Ensembl:ENSG00000138801 MIM:603262; AllianceGenome:HGNC:8603 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SK1; PAPSS; ATPSK1 Summary Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in endometrium (RPKM 32.6), brain (RPKM 30.3) and 25 other tissues See more Orthologs mouse all
PAPSS2, Official Symbol PAPSS2provided by HGNC Official Full Name 3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by HGNC Primary source HGNC:HGNC:8604 See related Ensembl:ENSG00000198682 MIM:603005; AllianceGenome:HGNC:8604 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SK2; BCYM4; ATPSK2 Summary Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in adrenal (RPKM 79.2), lung (RPKM 47.5) and 18 other tissues See more Orthologs mouse all
PAQR3, Official Symbol PAQR3provided by HGNC Official Full Name progestin and adipoQ receptor family member 3provided by HGNC Primary source HGNC:HGNC:30130 See related Ensembl:ENSG00000163291 MIM:614577; AllianceGenome:HGNC:30130 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RKTG Summary This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017] Expression Broad expression in testis (RPKM 20.7), brain (RPKM 8.5) and 24 other tissues See more Orthologs mouse all
PAQR4, Official Symbol PAQR4provided by HGNC Official Full Name progestin and adipoQ receptor family member 4provided by HGNC Primary source HGNC:HGNC:26386 See related Ensembl:ENSG00000162073 MIM:614578; AllianceGenome:HGNC:26386 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable signaling receptor activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 16.0), bone marrow (RPKM 6.3) and 22 other tissues See more Orthologs mouse all
PAQR5, Official Symbol PAQR5provided by HGNC Official Full Name progestin and adipoQ receptor family member 5provided by HGNC Primary source HGNC:HGNC:29645 See related Ensembl:ENSG00000137819 MIM:607781; AllianceGenome:HGNC:29645 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MPRG Summary Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 13.9), adrenal (RPKM 5.4) and 9 other tissues See more Orthologs mouse all
PAQR5-DT, Official Symbol PAQR5-DTprovided by HGNC Official Full Name PAQR5 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55353 See related Ensembl:ENSG00000261634 AllianceGenome:HGNC:55353 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in kidney (RPKM 3.1) and lung (RPKM 0.8) See more
PAQR6, Official Symbol PAQR6provided by HGNC Official Full Name progestin and adipoQ receptor family member 6provided by HGNC Primary source HGNC:HGNC:30132 See related Ensembl:ENSG00000160781 MIM:614579; AllianceGenome:HGNC:30132 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRdelta Summary Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 24.4), skin (RPKM 3.1) and 2 other tissues See more Orthologs mouse all
PAQR7, Official Symbol PAQR7provided by HGNC Official Full Name progestin and adipoQ receptor family member 7provided by HGNC Primary source HGNC:HGNC:23146 See related Ensembl:ENSG00000182749 MIM:607779; AllianceGenome:HGNC:23146 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as mSR; MPRA; PGLP Summary Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 22.0), testis (RPKM 21.9) and 22 other tissues See more Orthologs mouse all
PAQR8, Official Symbol PAQR8provided by HGNC Official Full Name progestin and adipoQ receptor family member 8provided by HGNC Primary source HGNC:HGNC:15708 See related Ensembl:ENSG00000170915 MIM:607780; AllianceGenome:HGNC:15708 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MPRB; LMPB1; C6orf33 Summary Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 26.8), colon (RPKM 23.1) and 21 other tissues See more Orthologs mouse all
PAQR9, Official Symbol PAQR9provided by HGNC Official Full Name progestin and adipoQ receptor family member 9provided by HGNC Primary source HGNC:HGNC:30131 See related Ensembl:ENSG00000188582 MIM:614580; AllianceGenome:HGNC:30131 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLNC1 Summary Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
PAQR9-AS1, Official Symbol PAQR9-AS1provided by HGNC Official Full Name PAQR9 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50861 See related Ensembl:ENSG00000241570 AllianceGenome:HGNC:50861 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in liver (RPKM 2.1), testis (RPKM 1.6) and 8 other tissues See more
PARD3, Official Symbol PARD3provided by HGNC Official Full Name par-3 family cell polarity regulatorprovided by HGNC Primary source HGNC:HGNC:16051 See related Ensembl:ENSG00000148498 MIM:606745; AllianceGenome:HGNC:16051 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Baz; ASIP; PAR3; PARD-3; PARD3A; SE2-5T2; PPP1R118; SE2-5L16; SE2-5LT1; PAR3alpha Summary This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in esophagus (RPKM 6.9), skin (RPKM 6.8) and 24 other tissues See more Orthologs mouse all
PARD3B, Official Symbol PARD3Bprovided by HGNC Official Full Name par-3 family cell polarity regulator betaprovided by HGNC Primary source HGNC:HGNC:14446 See related Ensembl:ENSG00000116117 MIM:619353; AllianceGenome:HGNC:14446 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAR3B; PAR3L; ALS2CR19; PAR3beta Summary Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Located in cell junction. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 1.4), fat (RPKM 1.3) and 24 other tissues See more Orthologs mouse all
PARD6A, Official Symbol PARD6Aprovided by HGNC Official Full Name par-6 family cell polarity regulator alphaprovided by HGNC Primary source HGNC:HGNC:15943 See related Ensembl:ENSG00000102981 MIM:607484; AllianceGenome:HGNC:15943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha Summary This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 9.8), brain (RPKM 5.0) and 23 other tissues See more Orthologs mouse all
PARD6B, Official Symbol PARD6Bprovided by HGNC Official Full Name par-6 family cell polarity regulator betaprovided by HGNC Primary source HGNC:HGNC:16245 See related Ensembl:ENSG00000124171 MIM:608975; AllianceGenome:HGNC:16245 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAR6B Summary This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 9.5), lung (RPKM 3.4) and 17 other tissues See more Orthologs mouse all
PARD6G, Official Symbol PARD6Gprovided by HGNC Official Full Name par-6 family cell polarity regulator gammaprovided by HGNC Primary source HGNC:HGNC:16076 See related Ensembl:ENSG00000178184 MIM:608976; AllianceGenome:HGNC:16076 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAR-6G; PAR6gamma Summary Predicted to enable protein kinase C binding activity. Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be located in cytosol and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 15.6), esophagus (RPKM 5.7) and 15 other tissues See more Orthologs mouse all
PARD6G-AS1, Official Symbol PARD6G-AS1provided by HGNC Official Full Name PARD6G antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44109 See related Ensembl:ENSG00000267270 AllianceGenome:HGNC:44109 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PARG, Official Symbol PARGprovided by HGNC Official Full Name poly(ADP-ribose) glycohydrolaseprovided by HGNC Primary source HGNC:HGNC:8605 See related Ensembl:ENSG00000227345 MIM:603501; AllianceGenome:HGNC:8605 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARG99 Summary Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in kidney (RPKM 6.5), testis (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
PARK7, Official Symbol PARK7provided by HGNC Official Full Name Parkinsonism associated deglycaseprovided by HGNC Primary source HGNC:HGNC:16369 See related Ensembl:ENSG00000116288 MIM:602533; AllianceGenome:HGNC:16369 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DJ1; DJ-1; GATD2; HEL-S-67p Summary The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 125.5), thyroid (RPKM 111.2) and 25 other tissues See more Orthologs mouse all
PARK7P1, Official Symbol PARK7P1provided by HGNC Official Full Name PARK7 pseudogene 1provided by HGNC Primary source HGNC:HGNC:55066 See related Ensembl:ENSG00000257243 AllianceGenome:HGNC:55066 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PARK7P2, Official Symbol PARK7P2provided by HGNC Official Full Name PARK7 pseudogene 2provided by HGNC Primary source HGNC:HGNC:55067 See related AllianceGenome:HGNC:55067 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PARL, Official Symbol PARLprovided by HGNC Official Full Name presenilin associated rhomboid likeprovided by HGNC Primary source HGNC:HGNC:18253 See related Ensembl:ENSG00000175193 MIM:607858; AllianceGenome:HGNC:18253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2 Summary This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016] Expression Ubiquitous expression in fat (RPKM 16.5), colon (RPKM 14.6) and 25 other tissues See more Orthologs mouse all
PARM1, Official Symbol PARM1provided by HGNC Official Full Name prostate androgen-regulated mucin-like protein 1provided by HGNC Primary source HGNC:HGNC:24536 See related Ensembl:ENSG00000169116 MIM:617688; AllianceGenome:HGNC:24536 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WSC4; Cipar1; PARM-1; DKFZP564O0823 Summary Predicted to be involved in positive regulation of telomerase activity. Located in several cellular components, including Golgi apparatus; endosome; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in thyroid (RPKM 83.3), colon (RPKM 61.9) and 21 other tissues See more Orthologs mouse all
PARM1-AS1, Official Symbol PARM1-AS1provided by HGNC Official Full Name PARM1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41051 See related Ensembl:ENSG00000249717 AllianceGenome:HGNC:41051 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PARN, Official Symbol PARNprovided by HGNC Official Full Name poly(A)-specific ribonucleaseprovided by HGNC Primary source HGNC:HGNC:8609 See related Ensembl:ENSG00000140694 MIM:604212; AllianceGenome:HGNC:8609 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAN; DKCB6; PFBMFT4 Summary The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in thyroid (RPKM 11.4), testis (RPKM 9.5) and 25 other tissues See more Orthologs mouse all
PARP1, Official Symbol PARP1provided by HGNC Official Full Name poly(ADP-ribose) polymerase 1provided by HGNC Primary source HGNC:HGNC:270 See related Ensembl:ENSG00000143799 MIM:173870; AllianceGenome:HGNC:270 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP Summary This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 71.4), appendix (RPKM 40.9) and 25 other tissues See more Orthologs mouse all
PARP10, Official Symbol PARP10provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 10provided by HGNC Primary source HGNC:HGNC:25895 See related Ensembl:ENSG00000178685 MIM:609564; AllianceGenome:HGNC:25895 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTD10 Summary Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in spleen (RPKM 25.6), lymph node (RPKM 16.2) and 25 other tissues See more Orthologs mouse all
PARP11, Official Symbol PARP11provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 11provided by HGNC Primary source HGNC:HGNC:1186 See related Ensembl:ENSG00000111224 MIM:616706; AllianceGenome:HGNC:1186 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTD11; MIB006; C12orf6 Summary Enables NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues See more Orthologs mouse all
PARP11-AS1, Official Symbol PARP11-AS1provided by HGNC Official Full Name PARP11 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40103 See related Ensembl:ENSG00000256862 AllianceGenome:HGNC:40103 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 3.2), lymph node (RPKM 0.7) and 2 other tissues See more
PARP12, Official Symbol PARP12provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 12provided by HGNC Primary source HGNC:HGNC:21919 See related Ensembl:ENSG00000059378 MIM:612481; AllianceGenome:HGNC:21919 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZC3H1; ARTD12; MST109; MSTP109; ZC3HDC1 Summary Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 11.7), small intestine (RPKM 11.3) and 25 other tissues See more Orthologs mouse all
PARP14, Official Symbol PARP14provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 14provided by HGNC Primary source HGNC:HGNC:29232 See related Ensembl:ENSG00000173193 MIM:610028; AllianceGenome:HGNC:29232 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAL2; ARTD8; pART8; PARP-14 Summary This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in spleen (RPKM 17.4), appendix (RPKM 15.1) and 24 other tissues See more Orthologs mouse all
PARP15, Official Symbol PARP15provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 15provided by HGNC Primary source HGNC:HGNC:26876 See related Ensembl:ENSG00000173200 MIM:612066; AllianceGenome:HGNC:26876 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAL3; ARTD7; pART7 Summary Enables NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II; protein mono-ADP-ribosylation; and protein poly-ADP-ribosylation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in spleen (RPKM 9.7), lymph node (RPKM 8.3) and 8 other tissues See more Orthologs all
PARP16, Official Symbol PARP16provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 16provided by HGNC Primary source HGNC:HGNC:26040 See related Ensembl:ENSG00000138617 MIM:620391; AllianceGenome:HGNC:26040 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTD15; pART15; C15orf30 Summary Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of protein serine/threonine kinase activity; and protein ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
PARP1P1, Official Symbol PARP1P1provided by HGNC Official Full Name poly(ADP-ribose) polymerase 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:275 See related Ensembl:ENSG00000227105 AllianceGenome:HGNC:275 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPOLP1; ADPRTP1
PARP2, Official Symbol PARP2provided by HGNC Official Full Name poly(ADP-ribose) polymerase 2provided by HGNC Primary source HGNC:HGNC:272 See related Ensembl:ENSG00000129484 MIM:607725; AllianceGenome:HGNC:272 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2 Summary This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues See more Orthologs mouse all
PARP3, Official Symbol PARP3provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 3provided by HGNC Primary source HGNC:HGNC:273 See related Ensembl:ENSG00000041880 MIM:607726; AllianceGenome:HGNC:273 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3 Summary The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues See more Orthologs mouse all
PARP4, Official Symbol PARP4provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 4provided by HGNC Primary source HGNC:HGNC:271 See related Ensembl:ENSG00000102699 MIM:607519; AllianceGenome:HGNC:271 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1 Summary This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 22.5), small intestine (RPKM 20.2) and 25 other tissues See more Orthologs mouse all
PARP4P1, Official Symbol PARP4P1provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:18500 See related Ensembl:ENSG00000237917 AllianceGenome:HGNC:18500 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARP4P; ADPRTL1P; PARP4PY1
PARP4P2, Official Symbol PARP4P2provided by HGNC Official Full Name poly(ADP-ribose) polymerase family member 4 pseudogene 2provided by HGNC Primary source HGNC:HGNC:37760 See related Ensembl:ENSG00000224976 AllianceGenome:HGNC:37760 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo