psui3905/ncbi_genes_summary huggingface dataset:
TEX264, Official Symbol TEX264provided by HGNC Official Full Name testis expressed 264, ER-phagy receptorprovided by HGNC Primary source HGNC:HGNC:30247 See related Ensembl:ENSG00000164081 AllianceGenome:HGNC:30247 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZSIG11 Summary Enables signaling receptor activity. Involved in protein-DNA covalent cross-linking repair. Acts upstream of or within reticulophagy. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum membrane; and replication fork. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 25.1), kidney (RPKM 16.6) and 25 other tissues See more Orthologs mouse all
TEX28, Official Symbol TEX28provided by HGNC Official Full Name testis expressed 28provided by HGNC Primary source HGNC:HGNC:2563 See related Ensembl:ENSG00000278057 MIM:300092; AllianceGenome:HGNC:2563 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as fTEX; MRX99; CXorf2; TEX28P1; TEX28P2 Summary Predicted to be integral component of membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 2.4) See more Orthologs mouse all
TEX28P1, Official Symbol TEX28P1provided by HGNC Official Full Name TEX28 pseudogene 1provided by HGNC Primary source HGNC:HGNC:33356 See related Ensembl:ENSG00000274962 AllianceGenome:HGNC:33356 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as pTEX
TEX28P2, Official Symbol TEX28P2provided by HGNC Official Full Name TEX28 pseudogene 2provided by HGNC Primary source HGNC:HGNC:33357 See related Ensembl:ENSG00000277008 AllianceGenome:HGNC:33357 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as pTEX; CXorf2B
TEX29, Official Symbol TEX29provided by HGNC Official Full Name testis expressed 29provided by HGNC Primary source HGNC:HGNC:20370 See related Ensembl:ENSG00000153495 AllianceGenome:HGNC:20370 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C13orf16; bA474D23.1 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 4.7) and brain (RPKM 0.3) See more Orthologs mouse all
TEX30, Official Symbol TEX30provided by HGNC Official Full Name testis expressed 30provided by HGNC Primary source HGNC:HGNC:25188 See related Ensembl:ENSG00000151287 AllianceGenome:HGNC:25188 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C13orf27 Summary Predicted to enable hydrolase activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 28.8), liver (RPKM 4.4) and 7 other tissues See more Orthologs mouse all
TEX35, Official Symbol TEX35provided by HGNC Official Full Name testis expressed 35provided by HGNC Primary source HGNC:HGNC:25366 See related Ensembl:ENSG00000240021 AllianceGenome:HGNC:25366 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSC24; C1orf49 Summary Located in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 26.3) See more Orthologs mouse all
TEX36, Official Symbol TEX36provided by HGNC Official Full Name testis expressed 36provided by HGNC Primary source HGNC:HGNC:31653 See related Ensembl:ENSG00000175018 AllianceGenome:HGNC:31653 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C10orf122; bA383C5.1 Expression Restricted expression toward testis (RPKM 3.8) See more Orthologs mouse all
TEX36-AS1, Official Symbol TEX36-AS1provided by HGNC Official Full Name TEX36 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49500 See related Ensembl:ENSG00000237675 AllianceGenome:HGNC:49500 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 7.4) See more
TEX38, Official Symbol TEX38provided by HGNC Official Full Name testis expressed 38provided by HGNC Primary source HGNC:HGNC:29589 See related Ensembl:ENSG00000186118 AllianceGenome:HGNC:29589 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as THEG4; C1orf223; ATPAF1-AS1 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 65.6) See more Orthologs mouse all
TEX41, Official Symbol TEX41provided by HGNC Official Full Name testis expressed 41provided by HGNC Primary source HGNC:HGNC:48667 See related Ensembl:ENSG00000226674 AllianceGenome:HGNC:48667 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00953; DKFZp686O1327 Expression Low expression observed in reference dataset See more
TEX44, Official Symbol TEX44provided by HGNC Official Full Name testis expressed 44provided by HGNC Primary source HGNC:HGNC:28563 See related Ensembl:ENSG00000177673 AllianceGenome:HGNC:28563 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf57 Summary Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
TEX46, Official Symbol TEX46provided by HGNC Official Full Name testis expressed 46provided by HGNC Primary source HGNC:HGNC:44651 See related Ensembl:ENSG00000227868 AllianceGenome:HGNC:44651 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEX#; C1orf234 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 14.1) See more Orthologs mouse all
TEX47, Official Symbol TEX47provided by HGNC Official Full Name testis expressed 47provided by HGNC Primary source HGNC:HGNC:22402 See related Ensembl:ENSG00000164645 AllianceGenome:HGNC:22402 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DYBLUF; C7orf62 Expression Restricted expression toward testis (RPKM 4.5) See more Orthologs mouse all
TEX48, Official Symbol TEX48provided by HGNC Official Full Name testis expressed 48provided by HGNC Primary source HGNC:HGNC:52393 See related Ensembl:ENSG00000230601 AllianceGenome:HGNC:52393 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 6.4) See more Orthologs mouse all
TEX50, Official Symbol TEX50provided by HGNC Official Full Name testis expressed 50provided by HGNC Primary source HGNC:HGNC:52382 See related Ensembl:ENSG00000232113 AllianceGenome:HGNC:52382 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 6.6) See more Orthologs mouse all
TEX51, Official Symbol TEX51provided by HGNC Official Full Name testis expressed 51provided by HGNC Primary source HGNC:HGNC:52387 See related Ensembl:ENSG00000237524 AllianceGenome:HGNC:52387 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 12.6) See more Orthologs mouse all
TEX52, Official Symbol TEX52provided by HGNC Official Full Name testis expressed 52provided by HGNC Primary source HGNC:HGNC:53643 See related Ensembl:ENSG00000283297 AllianceGenome:HGNC:53643 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 2.6), skin (RPKM 1.1) and 15 other tissues See more Orthologs mouse all
TEX53, Official Symbol TEX53provided by HGNC Official Full Name testis expressed 53provided by HGNC Primary source HGNC:HGNC:53655 See related Ensembl:ENSG00000230054 AllianceGenome:HGNC:53655 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 2.6) and spleen (RPKM 0.2) See more Orthologs mouse all
TEX54, Official Symbol TEX54provided by HGNC Official Full Name testis expressed 54provided by HGNC Primary source HGNC:HGNC:53729 See related Ensembl:ENSG00000283268 AllianceGenome:HGNC:53729 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs mouse all
TEX55, Official Symbol TEX55provided by HGNC Official Full Name testis expressed 55provided by HGNC Primary source HGNC:HGNC:26553 See related Ensembl:ENSG00000163424 AllianceGenome:HGNC:26553 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSCPA; C3orf30 Summary Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 46.8) See more Orthologs mouse all
TEX9, Official Symbol TEX9provided by HGNC Official Full Name testis expressed 9provided by HGNC Primary source HGNC:HGNC:29585 See related Ensembl:ENSG00000151575 AllianceGenome:HGNC:29585 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 5.0), thyroid (RPKM 4.2) and 23 other tissues See more Orthologs mouse all
TF, Official Symbol TFprovided by HGNC Official Full Name transferrinprovided by HGNC Primary source HGNC:HGNC:11740 See related Ensembl:ENSG00000091513 MIM:190000; AllianceGenome:HGNC:11740 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TFQTL1; PRO1557; PRO2086; HEL-S-71p Summary This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] Expression Restricted expression toward liver (RPKM 1622.3) See more Orthologs mouse all
TFAM, Official Symbol TFAMprovided by HGNC Official Full Name transcription factor A, mitochondrialprovided by HGNC Primary source HGNC:HGNC:11741 See related Ensembl:ENSG00000108064 MIM:600438; AllianceGenome:HGNC:11741 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15 Summary This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in testis (RPKM 11.2), thyroid (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
TFAMP2, Official Symbol TFAMP2provided by HGNC Official Full Name transcription factor A, mitochondrial pseudogene 2provided by HGNC Primary source HGNC:HGNC:11638 See related AllianceGenome:HGNC:11638 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTTF1; TCF6L3
TFAP2A, Official Symbol TFAP2Aprovided by HGNC Official Full Name transcription factor AP-2 alphaprovided by HGNC Primary source HGNC:HGNC:11742 See related Ensembl:ENSG00000137203 MIM:107580; AllianceGenome:HGNC:11742 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AP-2; BOFS; AP2TF; TFAP2; AP-2alpha Summary The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] Expression Biased expression in skin (RPKM 17.3), placenta (RPKM 12.3) and 5 other tissues See more Orthologs mouse all
TFAP2A-AS2, Official Symbol TFAP2A-AS2provided by HGNC Official Full Name TFAP2A antisense RNA 2provided by HGNC Primary source HGNC:HGNC:52289 See related Ensembl:ENSG00000285278 MIM:617136; AllianceGenome:HGNC:52289 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HIPSTR Summary The product of this intronless gene is a capped lncRNA that is nuclear-enriched and associated with chromatin. The encoded transcript may be involved in the regulation of developmental gene expression in a context-dependent manner, functioning as a repressor in non-pluripotent cells and an activator in pluripotent cells. Transcription of this gene is activated in 8-cell human embryos during the major wave of zygotic genome activation, independently of and prior to the activation of TFAP2A, an overlapping gene found on the opposite strand. Expression of this gene is characterized by high cell-to-cell variability in the cells of totipotent human embryos and in stable cell lines. [provided by RefSeq, Mar 2017]
TFAP2B, Official Symbol TFAP2Bprovided by HGNC Official Full Name transcription factor AP-2 betaprovided by HGNC Primary source HGNC:HGNC:11743 See related Ensembl:ENSG00000008196 MIM:601601; AllianceGenome:HGNC:11743 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDA2; AP-2B; AP2-B; AP-2beta Summary This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 3.0), skin (RPKM 2.7) and 4 other tissues See more Orthologs mouse all
TFAP2C, Official Symbol TFAP2Cprovided by HGNC Official Full Name transcription factor AP-2 gammaprovided by HGNC Primary source HGNC:HGNC:11744 See related Ensembl:ENSG00000087510 MIM:601602; AllianceGenome:HGNC:11744 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERF1; TFAP2G; hAP-2g; AP2-GAMMA Summary The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 24.1), placenta (RPKM 10.9) and 6 other tissues See more Orthologs mouse all
TFAP2D, Official Symbol TFAP2Dprovided by HGNC Official Full Name transcription factor AP-2 deltaprovided by HGNC Primary source HGNC:HGNC:15581 See related Ensembl:ENSG00000008197 MIM:610161; AllianceGenome:HGNC:15581 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TFAP2BL1; AP-2delta Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure development; regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within inferior colliculus development; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
TFAP2E, Official Symbol TFAP2Eprovided by HGNC Official Full Name transcription factor AP-2 epsilonprovided by HGNC Primary source HGNC:HGNC:30774 See related Ensembl:ENSG00000116819 MIM:614428; AllianceGenome:HGNC:30774 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AP2E; AP-2epsilon Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in anatomical structure development; regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 1.5), lymph node (RPKM 1.1) and 22 other tissues See more Orthologs mouse all
TFAP2E-AS1, Official Symbol TFAP2E-AS1provided by HGNC Official Full Name TFAP2E antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41274 See related Ensembl:ENSG00000239636 AllianceGenome:HGNC:41274 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in bone marrow (RPKM 1.1), spleen (RPKM 0.8) and 17 other tissues See more
TFAP4, Official Symbol TFAP4provided by HGNC Official Full Name transcription factor AP-4provided by HGNC Primary source HGNC:HGNC:11745 See related Ensembl:ENSG00000090447 MIM:600743; AllianceGenome:HGNC:11745 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AP-4; bHLHc41 Summary Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009] Expression Ubiquitous expression in ovary (RPKM 4.0), spleen (RPKM 3.0) and 25 other tissues See more Orthologs mouse all
TFB1M, Official Symbol TFB1Mprovided by HGNC Official Full Name transcription factor B1, mitochondrialprovided by HGNC Primary source HGNC:HGNC:17037 See related Ensembl:ENSG00000029639 MIM:607033; AllianceGenome:HGNC:17037 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI75; mtTFB; CGI-75; mtTFB1 Summary The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010] Expression Ubiquitous expression in testis (RPKM 2.2), adrenal (RPKM 1.8) and 25 other tissues See more Orthologs mouse all
TFB2M, Official Symbol TFB2Mprovided by HGNC Official Full Name transcription factor B2, mitochondrialprovided by HGNC Primary source HGNC:HGNC:18559 See related Ensembl:ENSG00000162851 MIM:607055; AllianceGenome:HGNC:18559 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hkp1; hTFB2M; mtTFB2; h-mtTFB; h-mtTFB2 Summary Enables mitochondrial transcription factor activity. Involved in transcription initiation from mitochondrial promoter. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 13.7), kidney (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
TFCP2, Official Symbol TFCP2provided by HGNC Official Full Name transcription factor CP2provided by HGNC Primary source HGNC:HGNC:11748 See related Ensembl:ENSG00000135457 MIM:189889; AllianceGenome:HGNC:11748 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LSF; SEF; LBP1C; LSF1D; TFCP2C Summary This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in appendix (RPKM 10.8), lymph node (RPKM 10.8) and 25 other tissues See more Orthologs mouse all
TFCP2L1, Official Symbol TFCP2L1provided by HGNC Official Full Name transcription factor CP2 like 1provided by HGNC Primary source HGNC:HGNC:17925 See related Ensembl:ENSG00000115112 MIM:609785; AllianceGenome:HGNC:17925 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LBP9; CRTR1; LBP-9 Summary Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and membrane. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 25.1), salivary gland (RPKM 23.9) and 10 other tissues See more Orthologs mouse all
TFDP1, Official Symbol TFDP1provided by HGNC Official Full Name transcription factor Dp-1provided by HGNC Primary source HGNC:HGNC:11749 See related Ensembl:ENSG00000198176 MIM:189902; AllianceGenome:HGNC:11749 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DP1; DILC; Dp-1; DRTF1 Summary This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009] Expression Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues See more Orthologs mouse all
TFDP1P3, Official Symbol TFDP1P3provided by HGNC Official Full Name TFDP1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:54931 See related AllianceGenome:HGNC:54931 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TFDP2, Official Symbol TFDP2provided by HGNC Official Full Name transcription factor Dp-2provided by HGNC Primary source HGNC:HGNC:11751 See related Ensembl:ENSG00000114126 MIM:602160; AllianceGenome:HGNC:11751 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DP2 Summary The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Ubiquitous expression in ovary (RPKM 7.2), testis (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
TFDP3, Official Symbol TFDP3provided by HGNC Official Full Name transcription factor Dp family member 3provided by HGNC Primary source HGNC:HGNC:24603 See related Ensembl:ENSG00000183434 MIM:300772; AllianceGenome:HGNC:24603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DP4; CT30; HCA661 Summary This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010] Orthologs all
TFE3, Official Symbol TFE3provided by HGNC Official Full Name transcription factor binding to IGHM enhancer 3provided by HGNC Primary source HGNC:HGNC:11752 See related Ensembl:ENSG00000068323 MIM:314310; AllianceGenome:HGNC:11752 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TFEA; RCCP2; RCCX1; MRXSPF; bHLHe33 Summary This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in fat (RPKM 31.1), adrenal (RPKM 17.6) and 25 other tissues See more Orthologs mouse all
TFEB, Official Symbol TFEBprovided by HGNC Official Full Name transcription factor EBprovided by HGNC Primary source HGNC:HGNC:11753 See related Ensembl:ENSG00000112561 MIM:600744; AllianceGenome:HGNC:11753 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCFEB; BHLHE35; ALPHATFEB Summary Enables DNA-binding transcription factor activity; enzyme binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to amino acid starvation; lysosome localization; and positive regulation of autophagy. Located in cytosol; lysosomal membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 9.7), lymph node (RPKM 8.3) and 25 other tissues See more Orthologs mouse all
TFEC, Official Symbol TFECprovided by HGNC Official Full Name transcription factor ECprovided by HGNC Primary source HGNC:HGNC:11754 See related Ensembl:ENSG00000105967 MIM:604732; AllianceGenome:HGNC:11754 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCFEC; TFE-C; TFECL; TFEC-L; bHLHe34; hTFEC-L Summary This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] Expression Broad expression in kidney (RPKM 6.5), appendix (RPKM 6.1) and 17 other tissues See more Orthologs mouse all
TFF1, Official Symbol TFF1provided by HGNC Official Full Name trefoil factor 1provided by HGNC Primary source HGNC:HGNC:11755 See related Ensembl:ENSG00000160182 MIM:113710; AllianceGenome:HGNC:11755 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as pS2; BCEI; HPS2; HP1.A; pNR-2; D21S21 Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Expression Restricted expression toward stomach (RPKM 2677.9) See more Orthologs mouse all
TFF2, Official Symbol TFF2provided by HGNC Official Full Name trefoil factor 2provided by HGNC Primary source HGNC:HGNC:11756 See related Ensembl:ENSG00000160181 MIM:182590; AllianceGenome:HGNC:11756 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SP; SML1 Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Expression Restricted expression toward stomach (RPKM 2591.2) See more Orthologs mouse all
TFF3, Official Symbol TFF3provided by HGNC Official Full Name trefoil factor 3provided by HGNC Primary source HGNC:HGNC:11757 See related Ensembl:ENSG00000160180 MIM:600633; AllianceGenome:HGNC:11757 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ITF; P1B; TFI Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Expression Biased expression in colon (RPKM 367.8), thyroid (RPKM 187.9) and 4 other tissues See more Orthologs mouse all
TFG, Official Symbol TFGprovided by HGNC Official Full Name trafficking from ER to golgi regulatorprovided by HGNC Primary source HGNC:HGNC:11758 See related Ensembl:ENSG00000114354 MIM:602498; AllianceGenome:HGNC:11758 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TF6; HMSNP; SPG57; TRKT3 Summary There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] Expression Ubiquitous expression in duodenum (RPKM 35.2), placenta (RPKM 33.3) and 25 other tissues See more Orthologs mouse all
TFGP1, Official Symbol TFGP1provided by HGNC Official Full Name TFG pseudogene 1provided by HGNC Primary source HGNC:HGNC:55068 See related Ensembl:ENSG00000217227 AllianceGenome:HGNC:55068 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TFIP11, Official Symbol TFIP11provided by HGNC Official Full Name tuftelin interacting protein 11provided by HGNC Primary source HGNC:HGNC:17165 See related Ensembl:ENSG00000100109 MIM:612747; AllianceGenome:HGNC:17165 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTR1; STIP; TIP39; STIP-1; Spp382; bK445C9.6 Summary This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] Expression Ubiquitous expression in testis (RPKM 20.2), bone marrow (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
TFIP11-DT, Official Symbol TFIP11-DTprovided by HGNC Official Full Name TFIP11 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55374 See related Ensembl:ENSG00000261188 AllianceGenome:HGNC:55374 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in thyroid (RPKM 3.2), brain (RPKM 3.0) and 25 other tissues See more
TFPI, Official Symbol TFPIprovided by HGNC Official Full Name tissue factor pathway inhibitorprovided by HGNC Primary source HGNC:HGNC:11760 See related Ensembl:ENSG00000003436 MIM:152310; AllianceGenome:HGNC:11760 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPI; TFI; LACI; TFPI1 Summary This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016] Expression Broad expression in liver (RPKM 42.6), placenta (RPKM 39.9) and 20 other tissues See more Orthologs mouse all
TFPI2, Official Symbol TFPI2provided by HGNC Official Full Name tissue factor pathway inhibitor 2provided by HGNC Primary source HGNC:HGNC:11761 See related Ensembl:ENSG00000105825 MIM:600033; AllianceGenome:HGNC:11761 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP5; REF1; TFPI-2 Summary This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Biased expression in placenta (RPKM 566.0) and fat (RPKM 18.9) See more Orthologs mouse all
TFPI2-DT, Official Symbol TFPI2-DTprovided by HGNC Official Full Name TFPI2 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:40581 See related Ensembl:ENSG00000234695 AllianceGenome:HGNC:40581 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward placenta (RPKM 88.0) See more
TFPT, Official Symbol TFPTprovided by HGNC Official Full Name TCF3 fusion partnerprovided by HGNC Primary source HGNC:HGNC:13630 See related Ensembl:ENSG00000105619 MIM:609519; AllianceGenome:HGNC:13630 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FB1; amida; INO80F Summary Predicted to enable DNA binding activity and protein kinase binding activity. Involved in apoptotic signaling pathway. Located in nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 11.2), prostate (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
TFR2, Official Symbol TFR2provided by HGNC Official Full Name transferrin receptor 2provided by HGNC Primary source HGNC:HGNC:11762 See related Ensembl:ENSG00000106327 MIM:604720; AllianceGenome:HGNC:11762 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HFE3; TFRC2 Summary This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] Expression Restricted expression toward liver (RPKM 143.5) See more Orthologs mouse all
TFRC, Official Symbol TFRCprovided by HGNC Official Full Name transferrin receptorprovided by HGNC Primary source HGNC:HGNC:11763 See related Ensembl:ENSG00000072274 MIM:190010; AllianceGenome:HGNC:11763 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46 Summary This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] Expression Broad expression in bone marrow (RPKM 101.5), placenta (RPKM 60.5) and 23 other tissues See more Orthologs mouse all
TG, Official Symbol TGprovided by HGNC Official Full Name thyroglobulinprovided by HGNC Primary source HGNC:HGNC:11764 See related Ensembl:ENSG00000042832 MIM:188450; AllianceGenome:HGNC:11764 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TGN; AITD3 Summary Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009] Expression Restricted expression toward thyroid (RPKM 4323.9) See more Orthologs mouse all