psui3905/ncbi_genes_summary huggingface dataset:
IDNK, Official Symbol IDNKprovided by HGNC Official Full Name IDNK gluconokinaseprovided by HGNC Primary source HGNC:HGNC:31367 See related Ensembl:ENSG00000148057 MIM:611343; AllianceGenome:HGNC:31367 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hGntK; C9orf103; bA522I20.2 Summary Predicted to enable gluconokinase activity. Predicted to be involved in D-gluconate catabolic process. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 3.7), liver (RPKM 2.2) and 25 other tissues See more Orthologs mouse all
IDO1, Official Symbol IDO1provided by HGNC Official Full Name indoleamine 2,3-dioxygenase 1provided by HGNC Primary source HGNC:HGNC:6059 See related Ensembl:ENSG00000131203 MIM:147435; AllianceGenome:HGNC:6059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IDO; INDO; IDO-1 Summary This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] Expression Biased expression in placenta (RPKM 49.9), lymph node (RPKM 25.9) and 9 other tissues See more Orthologs mouse all
IDO2, Official Symbol IDO2provided by HGNC Official Full Name indoleamine 2,3-dioxygenase 2provided by HGNC Primary source HGNC:HGNC:27269 See related Ensembl:ENSG00000188676 MIM:612129; AllianceGenome:HGNC:27269 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INDOL1 Summary Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011] Expression Biased expression in placenta (RPKM 9.5), liver (RPKM 2.8) and 3 other tissues See more Orthologs mouse all
IDS, Official Symbol IDSprovided by HGNC Official Full Name iduronate 2-sulfataseprovided by HGNC Primary source HGNC:HGNC:5389 See related Ensembl:ENSG00000010404 MIM:300823; AllianceGenome:HGNC:5389 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ID2S; MPS2; SIDS Summary This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Broad expression in brain (RPKM 168.5), adrenal (RPKM 29.7) and 21 other tissues See more Orthologs mouse all
IDUA, Official Symbol IDUAprovided by HGNC Official Full Name alpha-L-iduronidaseprovided by HGNC Primary source HGNC:HGNC:5391 See related Ensembl:ENSG00000127415 MIM:252800; AllianceGenome:HGNC:5391 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IDA; MPS1; MPSI Summary This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 4.2), stomach (RPKM 4.1) and 25 other tissues See more Orthologs mouse all
IER2, Official Symbol IER2provided by HGNC Official Full Name immediate early response 2provided by HGNC Primary source HGNC:HGNC:28871 See related Ensembl:ENSG00000160888 MIM:620036; AllianceGenome:HGNC:28871 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHX1; ETR101 Summary Predicted to enable DNA binding activity. Involved in cell motility and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 98.0), bone marrow (RPKM 95.1) and 24 other tissues See more Orthologs mouse all
IER3, Official Symbol IER3provided by HGNC Official Full Name immediate early response 3provided by HGNC Primary source HGNC:HGNC:5392 See related Ensembl:ENSG00000137331 MIM:602996; AllianceGenome:HGNC:5392 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L Summary This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 75.0), urinary bladder (RPKM 74.3) and 25 other tissues See more Orthologs mouse all
IER3-AS1, Official Symbol IER3-AS1provided by HGNC Official Full Name IER3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53629 See related Ensembl:ENSG00000272273 AllianceGenome:HGNC:53629 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in urinary bladder (RPKM 62.0), bone marrow (RPKM 61.0) and 25 other tissues See more
IER3IP1, Official Symbol IER3IP1provided by HGNC Official Full Name immediate early response 3 interacting protein 1provided by HGNC Primary source HGNC:HGNC:18550 See related Ensembl:ENSG00000134049 MIM:609382; AllianceGenome:HGNC:18550 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEDS; HSPC039; PRO2309 Summary This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in kidney (RPKM 41.1), thyroid (RPKM 27.9) and 25 other tissues See more Orthologs mouse all
IER5, Official Symbol IER5provided by HGNC Official Full Name immediate early response 5provided by HGNC Primary source HGNC:HGNC:5393 See related Ensembl:ENSG00000162783 MIM:607177; AllianceGenome:HGNC:5393 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SBBI48 Summary This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008] Orthologs mouse all
IER5L, Official Symbol IER5Lprovided by HGNC Official Full Name immediate early response 5 likeprovided by HGNC Primary source HGNC:HGNC:23679 See related Ensembl:ENSG00000188483 AllianceGenome:HGNC:23679 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bA247A12.2 Orthologs mouse all
IFFO1, Official Symbol IFFO1provided by HGNC Official Full Name intermediate filament family orphan 1provided by HGNC Primary source HGNC:HGNC:24970 See related Ensembl:ENSG00000010295 MIM:610495; AllianceGenome:HGNC:24970 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFFO; HOM-TES-103 Summary This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in spleen (RPKM 12.7), lymph node (RPKM 8.2) and 24 other tissues See more Orthologs mouse all
IFFO2, Official Symbol IFFO2provided by HGNC Official Full Name intermediate filament family orphan 2provided by HGNC Primary source HGNC:HGNC:27006 See related Ensembl:ENSG00000169991 AllianceGenome:HGNC:27006 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 29.4), esophagus (RPKM 16.7) and 18 other tissues See more Orthologs mouse all
IFI16, Official Symbol IFI16provided by HGNC Official Full Name interferon gamma inducible protein 16provided by HGNC Primary source HGNC:HGNC:5395 See related Ensembl:ENSG00000163565 MIM:147586; AllianceGenome:HGNC:5395 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PYHIN2; IFNGIP1 Summary This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] Expression Ubiquitous expression in lymph node (RPKM 45.3), appendix (RPKM 41.3) and 24 other tissues See more Orthologs all
IFI27, Official Symbol IFI27provided by HGNC Official Full Name interferon alpha inducible protein 27provided by HGNC Primary source HGNC:HGNC:5397 See related Ensembl:ENSG00000165949 MIM:600009; AllianceGenome:HGNC:5397 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P27; ISG12; FAM14D; ISG12A Summary Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Involved in several processes, including cellular protein metabolic process; defense response to other organism; and extrinsic apoptotic signaling pathway. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of protein export from nucleus. Located in mitochondrial membrane and nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in stomach (RPKM 224.1), spleen (RPKM 211.7) and 21 other tissues See more Orthologs all
IFI27L1, Official Symbol IFI27L1provided by HGNC Official Full Name interferon alpha inducible protein 27 like 1provided by HGNC Primary source HGNC:HGNC:19754 See related Ensembl:ENSG00000165948 MIM:611320; AllianceGenome:HGNC:19754 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM14B; ISG12C Summary Involved in apoptotic process. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 8.5), adrenal (RPKM 3.1) and 23 other tissues See more Orthologs all
IFI27L2, Official Symbol IFI27L2provided by HGNC Official Full Name interferon alpha inducible protein 27 like 2provided by HGNC Primary source HGNC:HGNC:19753 See related Ensembl:ENSG00000119632 MIM:611319; AllianceGenome:HGNC:19753 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLH29; FAM14A; ISG12B Summary Involved in apoptotic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 32.8), brain (RPKM 28.7) and 25 other tissues See more Orthologs mouse all
IFI30, Official Symbol IFI30provided by HGNC Official Full Name IFI30 lysosomal thiol reductaseprovided by HGNC Primary source HGNC:HGNC:5398 See related Ensembl:ENSG00000216490 MIM:604664; AllianceGenome:HGNC:5398 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GILT; IP30; IP-30; IFI-30 Summary The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 362.8), lung (RPKM 227.6) and 16 other tissues See more Orthologs mouse all
IFI35, Official Symbol IFI35provided by HGNC Official Full Name interferon induced protein 35provided by HGNC Primary source HGNC:HGNC:5399 See related Ensembl:ENSG00000068079 MIM:600735; AllianceGenome:HGNC:5399 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFP35 Summary Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of signal transduction. Located in several cellular components, including cytosol; extracellular space; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 18.2), appendix (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
IFI44, Official Symbol IFI44provided by HGNC Official Full Name interferon induced protein 44provided by HGNC Primary source HGNC:HGNC:16938 See related Ensembl:ENSG00000137965 MIM:610468; AllianceGenome:HGNC:16938 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p44; TLDC5; MTAP44 Summary Predicted to be involved in immune response. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 19.2), spleen (RPKM 17.3) and 24 other tissues See more Orthologs all
IFI44L, Official Symbol IFI44Lprovided by HGNC Official Full Name interferon induced protein 44 likeprovided by HGNC Primary source HGNC:HGNC:17817 See related Ensembl:ENSG00000137959 MIM:613975; AllianceGenome:HGNC:17817 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GS3686; TLDC5B; C1orf29 Summary Predicted to enable GTP binding activity. Involved in defense response to virus. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 16.8), bone marrow (RPKM 13.1) and 23 other tissues See more Orthologs mouse all
IFI6, Official Symbol IFI6provided by HGNC Official Full Name interferon alpha inducible protein 6provided by HGNC Primary source HGNC:HGNC:4054 See related Ensembl:ENSG00000126709 MIM:147572; AllianceGenome:HGNC:4054 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 6-16; G1P3; FAM14C; IFI616; IFI-6-16 Summary This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 111.6), salivary gland (RPKM 40.6) and 21 other tissues See more Orthologs all
IFIH1, Official Symbol IFIH1provided by HGNC Official Full Name interferon induced with helicase C domain 1provided by HGNC Primary source HGNC:HGNC:18873 See related Ensembl:ENSG00000115267 MIM:606951; AllianceGenome:HGNC:18873 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGS7; Hlcd; MDA5; IMD95; MDA-5; RLR-2; IDDM19; SGMRT1 Summary IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in spleen (RPKM 10.9), appendix (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
IFIT1, Official Symbol IFIT1provided by HGNC Official Full Name interferon induced protein with tetratricopeptide repeats 1provided by HGNC Primary source HGNC:HGNC:5407 See related Ensembl:ENSG00000185745 MIM:147690; AllianceGenome:HGNC:5407 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C56; P56; G10P1; IFI56; ISG56; IFI-56; IFIT-1; IFNAI1; RNM561; IFI-56K Summary This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in adrenal (RPKM 10.7), spleen (RPKM 10.7) and 25 other tissues See more Orthologs all
IFIT1B, Official Symbol IFIT1Bprovided by HGNC Official Full Name interferon induced protein with tetratricopeptide repeats 1Bprovided by HGNC Primary source HGNC:HGNC:23442 See related Ensembl:ENSG00000204010 AllianceGenome:HGNC:23442 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFIT1L; bA149I23.6 Summary Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward bone marrow (RPKM 10.2) See more Orthologs all
IFIT2, Official Symbol IFIT2provided by HGNC Official Full Name interferon induced protein with tetratricopeptide repeats 2provided by HGNC Primary source HGNC:HGNC:5409 See related Ensembl:ENSG00000119922 MIM:147040; AllianceGenome:HGNC:5409 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; ISG-54; GARG-39; IFI-54K; ISG-54K; ISG-54 K Summary Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 19.8), spleen (RPKM 15.9) and 24 other tissues See more Orthologs mouse all
IFIT3, Official Symbol IFIT3provided by HGNC Official Full Name interferon induced protein with tetratricopeptide repeats 3provided by HGNC Primary source HGNC:HGNC:5411 See related Ensembl:ENSG00000119917 MIM:604650; AllianceGenome:HGNC:5411 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49 Summary Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell population proliferation; and response to virus. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 22.6), lung (RPKM 21.1) and 24 other tissues See more Orthologs all
IFIT5, Official Symbol IFIT5provided by HGNC Official Full Name interferon induced protein with tetratricopeptide repeats 5provided by HGNC Primary source HGNC:HGNC:13328 See related Ensembl:ENSG00000152778 MIM:616135; AllianceGenome:HGNC:13328 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P58; RI58; ISG58 Summary Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 7.8), lung (RPKM 7.7) and 25 other tissues See more Orthologs all
IFITM1, Official Symbol IFITM1provided by HGNC Official Full Name interferon induced transmembrane protein 1provided by HGNC Primary source HGNC:HGNC:5412 See related Ensembl:ENSG00000185885 MIM:604456; AllianceGenome:HGNC:5412 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 9-27; CD225; IFI17; LEU13; DSPA2a Summary Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues See more Orthologs all
IFITM10, Official Symbol IFITM10provided by HGNC Official Full Name interferon induced transmembrane protein 10provided by HGNC Primary source HGNC:HGNC:40022 See related Ensembl:ENSG00000244242 MIM:618293; AllianceGenome:HGNC:40022 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DSPA3 Summary Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in adrenal (RPKM 13.9), brain (RPKM 6.2) and 11 other tissues See more Orthologs mouse all
IFITM2, Official Symbol IFITM2provided by HGNC Official Full Name interferon induced transmembrane protein 2provided by HGNC Primary source HGNC:HGNC:5413 See related Ensembl:ENSG00000185201 MIM:605578; AllianceGenome:HGNC:5413 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 1-8D; DSPA2c Summary Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in appendix (RPKM 262.7), spleen (RPKM 209.9) and 23 other tissues See more Orthologs all
IFITM3, Official Symbol IFITM3provided by HGNC Official Full Name interferon induced transmembrane protein 3provided by HGNC Primary source HGNC:HGNC:5414 See related Ensembl:ENSG00000142089 MIM:605579; AllianceGenome:HGNC:5414 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 1-8U; IP15; DSPA2b Summary Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in liver (RPKM 370.9), placenta (RPKM 358.2) and 25 other tissues See more Orthologs all
IFITM3P7, Official Symbol IFITM3P7provided by HGNC Official Full Name IFITM3 pseudogene 7provided by HGNC Primary source HGNC:HGNC:54546 See related AllianceGenome:HGNC:54546 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IFITM5, Official Symbol IFITM5provided by HGNC Official Full Name interferon induced transmembrane protein 5provided by HGNC Primary source HGNC:HGNC:16644 See related Ensembl:ENSG00000206013 MIM:614757; AllianceGenome:HGNC:16644 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OI5; BRIL; DSPA1; Hrmp1; fragilis4 Summary This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012] Expression Low expression observed in reference dataset See more Orthologs mouse all
IFITM8P, Official Symbol IFITM8Pprovided by HGNC Official Full Name interferon induced transmembrane protein 8 pseudogeneprovided by HGNC Primary source HGNC:HGNC:32202 See related AllianceGenome:HGNC:32202 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IFITM9P, Official Symbol IFITM9Pprovided by HGNC Official Full Name interferon induced transmembrane protein 9 pseudogeneprovided by HGNC Primary source HGNC:HGNC:33972 See related Ensembl:ENSG00000213275 AllianceGenome:HGNC:33972 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IFNA1, Official Symbol IFNA1provided by HGNC Official Full Name interferon alpha 1provided by HGNC Primary source HGNC:HGNC:5417 See related Ensembl:ENSG00000197919 MIM:147660; AllianceGenome:HGNC:5417 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFL; IFN; IFNA@; IFNA13; leIF D; IFN-ALPHA; IFN-alphaD Summary This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
IFNA10, Official Symbol IFNA10provided by HGNC Official Full Name interferon alpha 10provided by HGNC Primary source HGNC:HGNC:5418 See related Ensembl:ENSG00000186803 MIM:147577; AllianceGenome:HGNC:5418 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFN-alphaC Summary This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
IFNA11P, Official Symbol IFNA11Pprovided by HGNC Official Full Name interferon alpha 11, pseudogeneprovided by HGNC Primary source HGNC:HGNC:5442 See related Ensembl:ENSG00000231195 AllianceGenome:HGNC:5442 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFNP11
IFNA12P, Official Symbol IFNA12Pprovided by HGNC Official Full Name interferon alpha 12, pseudogeneprovided by HGNC Primary source HGNC:HGNC:5443 See related AllianceGenome:HGNC:5443 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFNP12; IFNWP12
IFNA13, Official Symbol IFNA13provided by HGNC Official Full Name interferon alpha 13provided by HGNC Primary source HGNC:HGNC:5419 See related Ensembl:ENSG00000233816 MIM:147578; AllianceGenome:HGNC:5419 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
IFNA14, Official Symbol IFNA14provided by HGNC Official Full Name interferon alpha 14provided by HGNC Primary source HGNC:HGNC:5420 See related Ensembl:ENSG00000228083 MIM:147579; AllianceGenome:HGNC:5420 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEIF2H; IFN-alphaH Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
IFNA16, Official Symbol IFNA16provided by HGNC Official Full Name interferon alpha 16provided by HGNC Primary source HGNC:HGNC:5421 See related Ensembl:ENSG00000147885 MIM:147580; AllianceGenome:HGNC:5421 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFN-alphaO; IFN-alpha-16 Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
IFNA17, Official Symbol IFNA17provided by HGNC Official Full Name interferon alpha 17provided by HGNC Primary source HGNC:HGNC:5422 See related Ensembl:ENSG00000234829 MIM:147583; AllianceGenome:HGNC:5422 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFNA; INFA; LEIF2C1; IFN-alphaI Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in Crimean-Congo hemorrhagic fever and sarcoidosis. [provided by Alliance of Genome Resources, Apr 2022]
IFNA2, Official Symbol IFNA2provided by HGNC Official Full Name interferon alpha 2provided by HGNC Primary source HGNC:HGNC:5423 See related Ensembl:ENSG00000188379 MIM:147562; AllianceGenome:HGNC:5423 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFNA; IFNA2B; leIF A; IFN-alphaA; IFN-alpha-2 Summary This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Orthologs all
IFNA20P, Official Symbol IFNA20Pprovided by HGNC Official Full Name interferon alpha 20, pseudogeneprovided by HGNC Primary source HGNC:HGNC:5444 See related Ensembl:ENSG00000226393 AllianceGenome:HGNC:5444 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFNP20
IFNA21, Official Symbol IFNA21provided by HGNC Official Full Name interferon alpha 21provided by HGNC Primary source HGNC:HGNC:5424 See related Ensembl:ENSG00000137080 MIM:147584; AllianceGenome:HGNC:5424 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LeIF F; leIF-F; IFN-alphaI Summary This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011] Orthologs all
IFNA4, Official Symbol IFNA4provided by HGNC Official Full Name interferon alpha 4provided by HGNC Primary source HGNC:HGNC:5425 See related Ensembl:ENSG00000236637 MIM:147564; AllianceGenome:HGNC:5425 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INFA4; IFN-alpha4a Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
IFNA5, Official Symbol IFNA5provided by HGNC Official Full Name interferon alpha 5provided by HGNC Primary source HGNC:HGNC:5426 See related Ensembl:ENSG00000147873 MIM:147565; AllianceGenome:HGNC:5426 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INA5; INFA5; leIF G; IFN-alphaG; IFN-alpha-5 Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
IFNA6, Official Symbol IFNA6provided by HGNC Official Full Name interferon alpha 6provided by HGNC Primary source HGNC:HGNC:5427 See related Ensembl:ENSG00000120235 MIM:147566; AllianceGenome:HGNC:5427 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFN-alphaK Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of anogenital venereal wart. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
IFNA7, Official Symbol IFNA7provided by HGNC Official Full Name interferon alpha 7provided by HGNC Primary source HGNC:HGNC:5428 See related Ensembl:ENSG00000214042 MIM:147567; AllianceGenome:HGNC:5428 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFNA-J; IFN-alphaJ Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
IFNA8, Official Symbol IFNA8provided by HGNC Official Full Name interferon alpha 8provided by HGNC Primary source HGNC:HGNC:5429 See related Ensembl:ENSG00000120242 MIM:147568; AllianceGenome:HGNC:5429 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFN-alphaB Summary Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to act upstream of or within defense response to virus. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all