psui3905/ncbi_genes_summary huggingface dataset:
MAGEA11, Official Symbol MAGEA11provided by HGNC Official Full Name MAGE family member A11provided by HGNC Primary source HGNC:HGNC:6798 See related Ensembl:ENSG00000185247 MIM:300344; AllianceGenome:HGNC:6798 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.11; MAGE11; MAGE-11; MAGEA-11 Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 1.8) See more Orthologs all
MAGEA12, Official Symbol MAGEA12provided by HGNC Official Full Name MAGE family member A12provided by HGNC Primary source HGNC:HGNC:6799 See related Ensembl:ENSG00000213401 MIM:300177; AllianceGenome:HGNC:6799 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.12; MAGE12 Summary This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014] Expression Restricted expression toward testis (RPKM 1.8) See more Orthologs all
MAGEA2, Official Symbol MAGEA2provided by HGNC Official Full Name MAGE family member A2provided by HGNC Primary source HGNC:HGNC:6800 See related Ensembl:ENSG00000268606 MIM:300173; AllianceGenome:HGNC:6800 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.2; MAGE2; MAGEA2A Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 2.8) See more Orthologs all
MAGEA2B, Official Symbol MAGEA2Bprovided by HGNC Official Full Name MAGE family member A2Bprovided by HGNC Primary source HGNC:HGNC:19340 See related Ensembl:ENSG00000183305 MIM:300549; AllianceGenome:HGNC:19340 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.2; MAGE2 Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 2.9) See more Orthologs all
MAGEA3, Official Symbol MAGEA3provided by HGNC Official Full Name MAGE family member A3provided by HGNC Primary source HGNC:HGNC:6801 See related Ensembl:ENSG00000221867 MIM:300174; AllianceGenome:HGNC:6801 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HIP8; HYPD; CT1.3; MAGE3; MAGEA6 Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 4.8) See more Orthologs all
MAGEA4, Official Symbol MAGEA4provided by HGNC Official Full Name MAGE family member A4provided by HGNC Primary source HGNC:HGNC:6802 See related Ensembl:ENSG00000147381 MIM:300175; AllianceGenome:HGNC:6802 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.4; MAGE4; MAGE4A; MAGE4B; MAGE-41; MAGE-X2 Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020] Expression Restricted expression toward testis (RPKM 13.7) See more Orthologs mouse all
MAGEA6, Official Symbol MAGEA6provided by HGNC Official Full Name MAGE family member A6provided by HGNC Primary source HGNC:HGNC:6804 See related Ensembl:ENSG00000197172 MIM:300176; AllianceGenome:HGNC:6804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.6; MAGE6; MAGE3B; MAGE-3b Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Restricted expression toward testis (RPKM 6.4) See more Orthologs all
MAGEA8, Official Symbol MAGEA8provided by HGNC Official Full Name MAGE family member A8provided by HGNC Primary source HGNC:HGNC:6806 See related Ensembl:ENSG00000156009 MIM:300341; AllianceGenome:HGNC:6806 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.8; MAGE8 Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009] Expression Restricted expression toward placenta (RPKM 6.3) See more Orthologs all
MAGEA9, Official Symbol MAGEA9provided by HGNC Official Full Name MAGE family member A9provided by HGNC Primary source HGNC:HGNC:6807 See related Ensembl:ENSG00000123584 MIM:300342; AllianceGenome:HGNC:6807 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT1.9; MAGE9 Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 5.4) See more Orthologs all
MAGEA9B, Official Symbol MAGEA9Bprovided by HGNC Official Full Name MAGE family member A9Bprovided by HGNC Primary source HGNC:HGNC:31909 See related Ensembl:ENSG00000267978 MIM:300764; AllianceGenome:HGNC:31909 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary MAGEA9B is a duplication of the MAGEA9 gene (MIM 300342) on chromosome Xq28. The 2 copies are separated by about 194 kb (Hartz, 2009).[supplied by OMIM, Mar 2009] Expression Restricted expression toward testis (RPKM 5.9) See more Orthologs all
MAGEB1, Official Symbol MAGEB1provided by HGNC Official Full Name MAGE family member B1provided by HGNC Primary source HGNC:HGNC:6808 See related Ensembl:ENSG00000214107 MIM:300097; AllianceGenome:HGNC:6808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT3.1; DAM10; MAGEL1; MAGE-Xp Summary This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 11.0) See more Orthologs all
MAGEB10, Official Symbol MAGEB10provided by HGNC Official Full Name MAGE family member B10provided by HGNC Primary source HGNC:HGNC:25377 See related Ensembl:ENSG00000177689 MIM:300761; AllianceGenome:HGNC:25377 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010] Expression Restricted expression toward testis (RPKM 1.6) See more Orthologs all
MAGEB16, Official Symbol MAGEB16provided by HGNC Official Full Name MAGE family member B16provided by HGNC Primary source HGNC:HGNC:21188 See related Ensembl:ENSG00000189023 MIM:300762; AllianceGenome:HGNC:21188 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 2.3) See more Orthologs mouse all
MAGEB17, Official Symbol MAGEB17provided by HGNC Official Full Name MAGE family member B17provided by HGNC Primary source HGNC:HGNC:17418 See related Ensembl:ENSG00000182798 MIM:300763; AllianceGenome:HGNC:17418 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
MAGEB18, Official Symbol MAGEB18provided by HGNC Official Full Name MAGE family member B18provided by HGNC Primary source HGNC:HGNC:28515 See related Ensembl:ENSG00000176774 MIM:301064; AllianceGenome:HGNC:28515 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
MAGEB2, Official Symbol MAGEB2provided by HGNC Official Full Name MAGE family member B2provided by HGNC Primary source HGNC:HGNC:6809 See related Ensembl:ENSG00000099399 MIM:300098; AllianceGenome:HGNC:6809 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAM6; CT3.2; MAGE-XP-2 Summary This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 20.5) See more Orthologs all
MAGEB3, Official Symbol MAGEB3provided by HGNC Official Full Name MAGE family member B3provided by HGNC Primary source HGNC:HGNC:6810 See related Ensembl:ENSG00000198798 MIM:300152; AllianceGenome:HGNC:6810 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT3.5 Summary This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 3.0) See more Orthologs all
MAGEB4, Official Symbol MAGEB4provided by HGNC Official Full Name MAGE family member B4provided by HGNC Primary source HGNC:HGNC:6811 See related Ensembl:ENSG00000120289 MIM:300153; AllianceGenome:HGNC:6811 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT3.6 Summary This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. [provided by RefSeq, Jul 2008] Orthologs all
MAGEB5, Official Symbol MAGEB5provided by HGNC Official Full Name MAGE family member B5provided by HGNC Primary source HGNC:HGNC:23795 See related Ensembl:ENSG00000188408 MIM:300466; AllianceGenome:HGNC:23795 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT3.3; MAGE-B5 Summary Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
MAGEB6, Official Symbol MAGEB6provided by HGNC Official Full Name MAGE family member B6provided by HGNC Primary source HGNC:HGNC:23796 See related Ensembl:ENSG00000176746 MIM:300467; AllianceGenome:HGNC:23796 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT3.4; MAGE-B6; MAGEB6A Summary This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 2.3) See more Orthologs all
MAGEB6B, Official Symbol MAGEB6Bprovided by HGNC Official Full Name MAGE family member B6Bprovided by HGNC Primary source HGNC:HGNC:28824 See related Ensembl:ENSG00000232030 AllianceGenome:HGNC:28824 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAGEB6P1 Summary Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
MAGEC1, Official Symbol MAGEC1provided by HGNC Official Full Name MAGE family member C1provided by HGNC Primary source HGNC:HGNC:6812 See related Ensembl:ENSG00000155495 MIM:300223; AllianceGenome:HGNC:6812 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT7; CT7.1 Summary This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 5.4) See more Orthologs all
MAGEC2, Official Symbol MAGEC2provided by HGNC Official Full Name MAGE family member C2provided by HGNC Primary source HGNC:HGNC:13574 See related Ensembl:ENSG00000046774 MIM:300468; AllianceGenome:HGNC:13574 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT10; HCA587; MAGEE1 Summary This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009] Expression Restricted expression toward testis (RPKM 15.6) See more Orthologs all
MAGEC3, Official Symbol MAGEC3provided by HGNC Official Full Name MAGE family member C3provided by HGNC Primary source HGNC:HGNC:23798 See related Ensembl:ENSG00000165509 MIM:300469; AllianceGenome:HGNC:23798 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCA2; CT7.2; MAGEC4; MAGE-C3 Summary This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
MAGED1, Official Symbol MAGED1provided by HGNC Official Full Name MAGE family member D1provided by HGNC Primary source HGNC:HGNC:6813 See related Ensembl:ENSG00000179222 MIM:300224; AllianceGenome:HGNC:6813 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRAGE; DLXIN-1 Summary This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 56.4), placenta (RPKM 55.0) and 25 other tissues See more Orthologs all
MAGED2, Official Symbol MAGED2provided by HGNC Official Full Name MAGE family member D2provided by HGNC Primary source HGNC:HGNC:16353 See related Ensembl:ENSG00000102316 MIM:300470; AllianceGenome:HGNC:16353 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 11B6; BCG1; BCG-1; HCA10; BARTS5; MAGE-D2 Summary This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in ovary (RPKM 106.4), prostate (RPKM 98.0) and 25 other tissues See more Orthologs mouse all
MAGED4, Official Symbol MAGED4provided by HGNC Official Full Name MAGE family member D4provided by HGNC Primary source HGNC:HGNC:23793 See related Ensembl:ENSG00000154545 MIM:300702; AllianceGenome:HGNC:23793 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAGE1; MAGEE1; MAGE-D4; MAGE-E1 Summary Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: There are two highly similar MAGED4 loci on the X chromosome, MAGED4 and MAGED4B. [04 Jan 2013] Expression Broad expression in brain (RPKM 36.4), endometrium (RPKM 15.3) and 14 other tissues See more Orthologs all
MAGED4B, Official Symbol MAGED4Bprovided by HGNC Official Full Name MAGE family member D4Bprovided by HGNC Primary source HGNC:HGNC:22880 See related Ensembl:ENSG00000187243 MIM:300765; AllianceGenome:HGNC:22880 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the MAGED gene family. It is expressed only in brain and ovary, and some transcript variants of this gene are specifically expressed in glioma cells. This gene is clustered with other MAGED genes on chromosome Xp11. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] Annotation information Note: There are two highly similar MAGED4 loci on the X chromosome. In June, 2007, the name of this locus was changed from MAGED4 to MAGED4B to conform to the annotation of the underlying clone. [20 Jun 2007] Expression Broad expression in brain (RPKM 32.3), endometrium (RPKM 13.7) and 14 other tissues See more
MAGEE1, Official Symbol MAGEE1provided by HGNC Official Full Name MAGE family member E1provided by HGNC Primary source HGNC:HGNC:24934 See related Ensembl:ENSG00000198934 MIM:300759; AllianceGenome:HGNC:24934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCA1; DAMAGE Summary This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010] Orthologs mouse all
MAGEE2, Official Symbol MAGEE2provided by HGNC Official Full Name MAGE family member E2provided by HGNC Primary source HGNC:HGNC:24935 See related Ensembl:ENSG00000186675 MIM:300760; AllianceGenome:HGNC:24935 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCA3 Summary This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011] Orthologs mouse all
MAGEF1, Official Symbol MAGEF1provided by HGNC Official Full Name MAGE family member F1provided by HGNC Primary source HGNC:HGNC:29639 See related Ensembl:ENSG00000177383 MIM:609267; AllianceGenome:HGNC:29639 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAGE-F1 Summary This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008] Orthologs all
MAGEH1, Official Symbol MAGEH1provided by HGNC Official Full Name MAGE family member H1provided by HGNC Primary source HGNC:HGNC:24092 See related Ensembl:ENSG00000187601 MIM:300548; AllianceGenome:HGNC:24092 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APR1; APR-1; MAGEH Summary This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013] Orthologs mouse all
MAGEL2, Official Symbol MAGEL2provided by HGNC Official Full Name MAGE family member L2provided by HGNC Primary source HGNC:HGNC:6814 See related Ensembl:ENSG00000254585 MIM:605283; AllianceGenome:HGNC:6814 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PWLS; nM15; NDNL1; SHFYNG Summary Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010] Orthologs mouse all
MAGI1, Official Symbol MAGI1provided by HGNC Official Full Name membrane associated guanylate kinase, WW and PDZ domain containing 1provided by HGNC Primary source HGNC:HGNC:946 See related Ensembl:ENSG00000151276 MIM:602625; AllianceGenome:HGNC:946 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIP3; BAP1; WWP3; AIP-3; BAP-1; BAIAP1; MAGI-1; Magi1d; TNRC19; MAGI-1b Summary The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 5.4), brain (RPKM 4.9) and 24 other tissues See more Orthologs mouse all
MAGI1-AS1, Official Symbol MAGI1-AS1provided by HGNC Official Full Name MAGI1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40091 See related Ensembl:ENSG00000240175 AllianceGenome:HGNC:40091 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MAGI1-IT1, Official Symbol MAGI1-IT1provided by HGNC Official Full Name MAGI1 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:42436 See related Ensembl:ENSG00000272610 AllianceGenome:HGNC:42436 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MAGI2, Official Symbol MAGI2provided by HGNC Official Full Name membrane associated guanylate kinase, WW and PDZ domain containing 2provided by HGNC Primary source HGNC:HGNC:18957 See related Ensembl:ENSG00000187391 MIM:606382; AllianceGenome:HGNC:18957 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; NPHS15; ACVRIP1 Summary The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Broad expression in brain (RPKM 4.1), thyroid (RPKM 1.2) and 16 other tissues See more Orthologs mouse all
MAGI2-AS2, Official Symbol MAGI2-AS2provided by HGNC Official Full Name MAGI2 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40861 See related Ensembl:ENSG00000226978 AllianceGenome:HGNC:40861 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MAGI2-AS3, Official Symbol MAGI2-AS3provided by HGNC Official Full Name MAGI2 antisense RNA 3provided by HGNC Primary source HGNC:HGNC:40862 See related Ensembl:ENSG00000234456 AllianceGenome:HGNC:40862 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in fat (RPKM 9.7), ovary (RPKM 7.7) and 23 other tissues See more
MAGI3, Official Symbol MAGI3provided by HGNC Official Full Name membrane associated guanylate kinase, WW and PDZ domain containing 3provided by HGNC Primary source HGNC:HGNC:29647 See related Ensembl:ENSG00000081026 MIM:615943; AllianceGenome:HGNC:29647 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAGI-3; dJ730K3.2 Summary Predicted to enable frizzled binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lung (RPKM 6.5), thyroid (RPKM 5.4) and 24 other tissues See more Orthologs mouse all
MAGIX, Official Symbol MAGIXprovided by HGNC Official Full Name MAGI family member, X-linkedprovided by HGNC Primary source HGNC:HGNC:30006 See related Ensembl:ENSG00000269313 AllianceGenome:HGNC:30006 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JM10; PDZX Expression Ubiquitous expression in stomach (RPKM 1.5), kidney (RPKM 1.3) and 25 other tissues See more Orthologs mouse all
MAGOH, Official Symbol MAGOHprovided by HGNC Official Full Name mago homolog, exon junction complex subunitprovided by HGNC Primary source HGNC:HGNC:6815 See related Ensembl:ENSG00000162385 MIM:602603; AllianceGenome:HGNC:6815 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAGOH1; MAGOHA Summary Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 28.8), colon (RPKM 24.3) and 25 other tissues See more Orthologs mouse all
MAGOHB, Official Symbol MAGOHBprovided by HGNC Official Full Name mago homolog B, exon junction complex subunitprovided by HGNC Primary source HGNC:HGNC:25504 See related Ensembl:ENSG00000111196 MIM:619552; AllianceGenome:HGNC:25504 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGN2; mago; magoh Summary Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 3.2), appendix (RPKM 3.0) and 25 other tissues See more Orthologs mouse all
MAGT1, Official Symbol MAGT1provided by HGNC Official Full Name magnesium transporter 1provided by HGNC Primary source HGNC:HGNC:28880 See related Ensembl:ENSG00000102158 MIM:300715; AllianceGenome:HGNC:28880 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IAP; XMEN; MRX95; OST3B; CDG1CC; PRO0756; SLC58A1; bA217H1.1 Summary This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in thyroid (RPKM 54.7), kidney (RPKM 22.6) and 25 other tissues See more Orthologs mouse all
MAIP1, Official Symbol MAIP1provided by HGNC Official Full Name matrix AAA peptidase interacting protein 1provided by HGNC Primary source HGNC:HGNC:26198 See related Ensembl:ENSG00000162972 MIM:617267; AllianceGenome:HGNC:26198 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf47 Summary Predicted to enable ribosome binding activity. Involved in calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and protein insertion into mitochondrial membrane. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 12.0), liver (RPKM 9.3) and 25 other tissues See more Orthologs mouse all
MAJIN, Official Symbol MAJINprovided by HGNC Official Full Name membrane anchored junction proteinprovided by HGNC Primary source HGNC:HGNC:27441 See related Ensembl:ENSG00000168070 MIM:617130; AllianceGenome:HGNC:27441 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C11orf85 Summary Predicted to enable DNA binding activity. Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to be located in chromosome, telomeric region. Predicted to be integral component of nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 5.4) See more Orthologs mouse all
MAK, Official Symbol MAKprovided by HGNC Official Full Name male germ cell associated kinaseprovided by HGNC Primary source HGNC:HGNC:6816 See related Ensembl:ENSG00000111837 MIM:154235; AllianceGenome:HGNC:6816 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP62 Summary The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Biased expression in testis (RPKM 3.9), lung (RPKM 0.4) and 3 other tissues See more Orthologs mouse all
MAK16, Official Symbol MAK16provided by HGNC Official Full Name MAK16 homologprovided by HGNC Primary source HGNC:HGNC:13703 See related Ensembl:ENSG00000198042 AllianceGenome:HGNC:13703 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RBM13; MAK16L Summary Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 5.6), appendix (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
MAL, Official Symbol MALprovided by HGNC Official Full Name mal, T cell differentiation proteinprovided by HGNC Primary source HGNC:HGNC:6817 See related Ensembl:ENSG00000172005 MIM:188860; AllianceGenome:HGNC:6817 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MVP17; VIP17 Summary The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012] Annotation information Note: MAL (Gene ID: 4118), TIRAP (Gene ID: 114609), and MKL1 (Gene ID: 57591) share the MAL symbol/alias in common. MAL is a widely used alternative name for TIR domain containing adaptor protein (TIRAP) and megakaryoblastic leukemia (translocation) 1 (MKL1). [23 May 2018] Expression Biased expression in esophagus (RPKM 937.0) and kidney (RPKM 115.6) See more Orthologs mouse all
MAL2, Official Symbol MAL2provided by HGNC Official Full Name mal, T cell differentiation protein 2provided by HGNC Primary source HGNC:HGNC:13634 See related Ensembl:ENSG00000147676 MIM:609684; AllianceGenome:HGNC:13634 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 140.3), thyroid (RPKM 100.0) and 16 other tissues See more Orthologs mouse all
MAL2-AS1, Official Symbol MAL2-AS1provided by HGNC Official Full Name MAL2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53626 See related Ensembl:ENSG00000253972 AllianceGenome:HGNC:53626 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more