psui3905/ncbi_genes_summary huggingface dataset:
SCTR, Official Symbol SCTRprovided by HGNC Official Full Name secretin receptorprovided by HGNC Primary source HGNC:HGNC:10608 See related Ensembl:ENSG00000080293 MIM:182098; AllianceGenome:HGNC:10608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SR Summary The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008] Expression Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues See more Orthologs mouse all
SCTR-AS1, Official Symbol SCTR-AS1provided by HGNC Official Full Name SCTR antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40516 See related Ensembl:ENSG00000231013 AllianceGenome:HGNC:40516 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SCUBE1, Official Symbol SCUBE1provided by HGNC Official Full Name signal peptide, CUB domain and EGF like domain containing 1provided by HGNC Primary source HGNC:HGNC:13441 See related Ensembl:ENSG00000159307 MIM:611746; AllianceGenome:HGNC:13441 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011] Expression Broad expression in ovary (RPKM 8.0), testis (RPKM 5.9) and 17 other tissues See more Orthologs mouse all
SCUBE1-AS1, Official Symbol SCUBE1-AS1provided by HGNC Official Full Name SCUBE1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40635 See related Ensembl:ENSG00000203527 AllianceGenome:HGNC:40635 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
SCUBE1-AS2, Official Symbol SCUBE1-AS2provided by HGNC Official Full Name SCUBE1 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40633 See related Ensembl:ENSG00000236272 AllianceGenome:HGNC:40633 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 2.4), lung (RPKM 0.3) and 1 other tissue See more
SCUBE2, Official Symbol SCUBE2provided by HGNC Official Full Name signal peptide, CUB domain and EGF like domain containing 2provided by HGNC Primary source HGNC:HGNC:30425 See related Ensembl:ENSG00000175356 MIM:611747; AllianceGenome:HGNC:30425 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEGB1; CEGF1; CEGP1; scube/You Summary Predicted to enable calcium ion binding activity; hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in prostate (RPKM 8.1), urinary bladder (RPKM 7.3) and 20 other tissues See more Orthologs mouse all
SCUBE3, Official Symbol SCUBE3provided by HGNC Official Full Name signal peptide, CUB domain and EGF like domain containing 3provided by HGNC Primary source HGNC:HGNC:13655 See related Ensembl:ENSG00000146197 MIM:614708; AllianceGenome:HGNC:13655 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEGF3; SSFSC2 Summary This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Biased expression in thyroid (RPKM 18.5), adrenal (RPKM 1.4) and 2 other tissues See more Orthologs mouse all
SCX, Official Symbol SCXprovided by HGNC Official Full Name scleraxis bHLH transcription factorprovided by HGNC Primary source HGNC:HGNC:32322 See related Ensembl:ENSG00000260428 MIM:609067; AllianceGenome:HGNC:32322 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCXA; SCXB; bHLHa48 Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: In the NCBI Build GRCh37 reference assembly SCXA and SCXB are duplicate genes in close proximity to each other on chromosome 8. In August, 2010 the Genome Reference Consortium determined that the region contains a duplication error. The clone on which SCXA was based (AC110280.8) was be removed from the GRCh38 reference assembly and SCXB was retained and renamed to SCX. [27 Sep 2015] Expression Ubiquitous expression in appendix (RPKM 1.6), prostate (RPKM 1.6) and 25 other tissues See more Orthologs mouse all
SCYGR1, Official Symbol SCYGR1provided by HGNC Official Full Name small cysteine and glycine repeat containing 1provided by HGNC Primary source HGNC:HGNC:34218 See related Ensembl:ENSG00000284629 AllianceGenome:HGNC:34218 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-1 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022]
SCYGR10, Official Symbol SCYGR10provided by HGNC Official Full Name small cysteine and glycine repeat containing 10 (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:34221 See related Ensembl:ENSG00000284622 AllianceGenome:HGNC:34221 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28p2; KRTAP28-10 Summary This gene is a member of a large gene family that encodes keratin associated proteins (KRTAP) that play a role in hair formation. This gene belongs to a subfamily of the KRTAP family termed small cysteine and glycine repeat containing (SCYGR) genes and it resides in a cluster of SCYGR genes on chromosome 2q36.3. Allelic polymorphisms in this gene result in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Sep 2021]
SCYGR2, Official Symbol SCYGR2provided by HGNC Official Full Name small cysteine and glycine repeat containing 2provided by HGNC Primary source HGNC:HGNC:34220 See related Ensembl:ENSG00000284643 AllianceGenome:HGNC:34220 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-2 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022]
SCYGR3, Official Symbol SCYGR3provided by HGNC Official Full Name small cysteine and glycine repeat containing 3provided by HGNC Primary source HGNC:HGNC:34222 See related Ensembl:ENSG00000284704 AllianceGenome:HGNC:34222 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-3 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
SCYGR4, Official Symbol SCYGR4provided by HGNC Official Full Name small cysteine and glycine repeat containing 4provided by HGNC Primary source HGNC:HGNC:34223 See related Ensembl:ENSG00000284631 AllianceGenome:HGNC:34223 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-4 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022]
SCYGR5, Official Symbol SCYGR5provided by HGNC Official Full Name small cysteine and glycine repeat containing 5provided by HGNC Primary source HGNC:HGNC:34224 See related Ensembl:ENSG00000284667 AllianceGenome:HGNC:34224 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-5 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022]
SCYGR6, Official Symbol SCYGR6provided by HGNC Official Full Name small cysteine and glycine repeat containing 6provided by HGNC Primary source HGNC:HGNC:34225 See related Ensembl:ENSG00000284725 AllianceGenome:HGNC:34225 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-6 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
SCYGR7, Official Symbol SCYGR7provided by HGNC Official Full Name small cysteine and glycine repeat containing 7provided by HGNC Primary source HGNC:HGNC:34226 See related Ensembl:ENSG00000284718 AllianceGenome:HGNC:34226 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-7 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
SCYGR8, Official Symbol SCYGR8provided by HGNC Official Full Name small cysteine and glycine repeat containing 8provided by HGNC Primary source HGNC:HGNC:34227 See related Ensembl:ENSG00000284635 AllianceGenome:HGNC:34227 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-8 Summary Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
SCYGR9, Official Symbol SCYGR9provided by HGNC Official Full Name small cysteine and glycine repeat containing 9 (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:34219 See related Ensembl:ENSG00000285843 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRTAP28-9; KRTAP28p1
SCYL1, Official Symbol SCYL1provided by HGNC Official Full Name SCY1 like pseudokinase 1provided by HGNC Primary source HGNC:HGNC:14372 See related Ensembl:ENSG00000142186 MIM:607982; AllianceGenome:HGNC:14372 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; SCAR21 Summary This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 23.2), ovary (RPKM 22.4) and 25 other tissues See more Orthologs mouse all
SCYL2, Official Symbol SCYL2provided by HGNC Official Full Name SCY1 like pseudokinase 2provided by HGNC Primary source HGNC:HGNC:19286 See related Ensembl:ENSG00000136021 MIM:616365; AllianceGenome:HGNC:19286 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AMC4; AMCNACC; CVAK104 Summary The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in colon (RPKM 12.7), esophagus (RPKM 10.5) and 25 other tissues See more Orthologs mouse all
SCYL2P1, Official Symbol SCYL2P1provided by HGNC Official Full Name SCYL2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54685 See related Ensembl:ENSG00000213090 AllianceGenome:HGNC:54685 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SCYL3, Official Symbol SCYL3provided by HGNC Official Full Name SCY1 like pseudokinase 3provided by HGNC Primary source HGNC:HGNC:19285 See related Ensembl:ENSG00000000457 MIM:608192; AllianceGenome:HGNC:19285 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PACE1; PACE-1 Summary This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012] Expression Ubiquitous expression in lymph node (RPKM 4.6), testis (RPKM 4.3) and 25 other tissues See more Orthologs mouse all
SDAD1, Official Symbol SDAD1provided by HGNC Official Full Name SDA1 domain containing 1provided by HGNC Primary source HGNC:HGNC:25537 See related Ensembl:ENSG00000198301 AllianceGenome:HGNC:25537 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Sda1 Summary Predicted to be involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 19.5), thyroid (RPKM 18.4) and 25 other tissues See more Orthologs mouse all
SDAD1-AS1, Official Symbol SDAD1-AS1provided by HGNC Official Full Name SDAD1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41106 See related Ensembl:ENSG00000245928 AllianceGenome:HGNC:41106 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
SDAD1P1, Official Symbol SDAD1P1provided by HGNC Official Full Name SDA1 domain containing 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:31403 See related Ensembl:ENSG00000228451 AllianceGenome:HGNC:31403 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDAD1P3, Official Symbol SDAD1P3provided by HGNC Official Full Name SDA1 domain containing 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:39260 See related Ensembl:ENSG00000227707 AllianceGenome:HGNC:39260 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDAD1P4, Official Symbol SDAD1P4provided by HGNC Official Full Name SDA1 domain containing 1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:39261 See related Ensembl:ENSG00000236803 AllianceGenome:HGNC:39261 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDC1, Official Symbol SDC1provided by HGNC Official Full Name syndecan 1provided by HGNC Primary source HGNC:HGNC:10658 See related Ensembl:ENSG00000115884 MIM:186355; AllianceGenome:HGNC:10658 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDC; CD138; SYND1; syndecan Summary The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 110.6), skin (RPKM 101.9) and 14 other tissues See more Orthologs mouse all
SDC2, Official Symbol SDC2provided by HGNC Official Full Name syndecan 2provided by HGNC Primary source HGNC:HGNC:10659 See related Ensembl:ENSG00000169439 MIM:142460; AllianceGenome:HGNC:10659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSPG; CD362; HSPG1; SYND2 Summary The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 143.2), liver (RPKM 70.5) and 19 other tissues See more Orthologs mouse all
SDC3, Official Symbol SDC3provided by HGNC Official Full Name syndecan 3provided by HGNC Primary source HGNC:HGNC:10660 See related Ensembl:ENSG00000162512 MIM:186357; AllianceGenome:HGNC:10660 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDCN; SYND3 Summary The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009] Expression Broad expression in brain (RPKM 64.6), spleen (RPKM 56.5) and 21 other tissues See more Orthologs mouse all
SDC4, Official Symbol SDC4provided by HGNC Official Full Name syndecan 4provided by HGNC Primary source HGNC:HGNC:10661 See related Ensembl:ENSG00000124145 MIM:600017; AllianceGenome:HGNC:10661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SYND4 Summary The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 189.5), lung (RPKM 100.6) and 23 other tissues See more Orthologs mouse all
SDCBP, Official Symbol SDCBPprovided by HGNC Official Full Name syndecan binding proteinprovided by HGNC Primary source HGNC:HGNC:10662 See related Ensembl:ENSG00000137575 MIM:602217; AllianceGenome:HGNC:10662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ST1; MDA9; SYCL; MDA-9; SDCBP1; TACIP18 Summary The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in placenta (RPKM 77.0), gall bladder (RPKM 73.7) and 25 other tissues See more Orthologs mouse all
SDCBP2, Official Symbol SDCBP2provided by HGNC Official Full Name syndecan binding protein 2provided by HGNC Primary source HGNC:HGNC:15756 See related Ensembl:ENSG00000125775 MIM:617358; AllianceGenome:HGNC:15756 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ST2; ST-2; SITAC; SITAC18 Summary The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011] Expression Biased expression in duodenum (RPKM 54.3), small intestine (RPKM 53.5) and 8 other tissues See more Orthologs mouse all
SDCBP2-AS1, Official Symbol SDCBP2-AS1provided by HGNC Official Full Name SDCBP2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44314 See related Ensembl:ENSG00000234684 AllianceGenome:HGNC:44314 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in adrenal (RPKM 1.8), thyroid (RPKM 1.5) and 25 other tissues See more
SDCBP2P1, Official Symbol SDCBP2P1provided by HGNC Official Full Name syndecan binding protein 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44685 See related Ensembl:ENSG00000223389 AllianceGenome:HGNC:44685 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDCBPP1, Official Symbol SDCBPP1provided by HGNC Official Full Name syndecan binding protein pseudogene 1provided by HGNC Primary source HGNC:HGNC:44684 See related Ensembl:ENSG00000226705 AllianceGenome:HGNC:44684 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDCBPP2, Official Symbol SDCBPP2provided by HGNC Official Full Name syndecan binding protein pseudogene 2provided by HGNC Primary source HGNC:HGNC:44686 See related AllianceGenome:HGNC:44686 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDCBPP3, Official Symbol SDCBPP3provided by HGNC Official Full Name syndecan binding protein pseudogene 3provided by HGNC Primary source HGNC:HGNC:44687 See related Ensembl:ENSG00000232801 AllianceGenome:HGNC:44687 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDCCAG8, Official Symbol SDCCAG8provided by HGNC Official Full Name SHH signaling and ciliogenesis regulator SDCCAG8provided by HGNC Primary source HGNC:HGNC:10671 See related Ensembl:ENSG00000054282 MIM:613524; AllianceGenome:HGNC:10671 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BBS16; CCCAP; SLSN7; NPHP10; hCCCAP; HSPC085; NY-CO-8; CCCAP SLSN7 Summary This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in thyroid (RPKM 5.5), lung (RPKM 3.0) and 25 other tissues See more Orthologs mouse all
SDE2, Official Symbol SDE2provided by HGNC Official Full Name SDE2 telomere maintenance homologprovided by HGNC Primary source HGNC:HGNC:26643 See related Ensembl:ENSG00000143751 AllianceGenome:HGNC:26643 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1orf55; dJ671D7.1 Summary Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 11.6), thyroid (RPKM 7.7) and 25 other tissues See more Orthologs mouse all
SDF2, Official Symbol SDF2provided by HGNC Official Full Name stromal cell derived factor 2provided by HGNC Primary source HGNC:HGNC:10675 See related Ensembl:ENSG00000132581 MIM:602934; AllianceGenome:HGNC:10675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. Alternate splicing results in both coding and non-coding variants. A pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in adrenal (RPKM 19.5), placenta (RPKM 16.0) and 25 other tissues See more Orthologs mouse all
SDF2L1, Official Symbol SDF2L1provided by HGNC Official Full Name stromal cell derived factor 2 like 1provided by HGNC Primary source HGNC:HGNC:10676 See related Ensembl:ENSG00000128228 MIM:607551; AllianceGenome:HGNC:10676 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables misfolded protein binding activity. Involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 15.5), stomach (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
SDF4, Official Symbol SDF4provided by HGNC Official Full Name stromal cell derived factor 4provided by HGNC Primary source HGNC:HGNC:24188 See related Ensembl:ENSG00000078808 MIM:614282; AllianceGenome:HGNC:24188 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cab45; SDF-4 Summary This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in colon (RPKM 31.3), kidney (RPKM 26.5) and 25 other tissues See more Orthologs mouse all
SDHA, Official Symbol SDHAprovided by HGNC Official Full Name succinate dehydrogenase complex flavoprotein subunit Aprovided by HGNC Primary source HGNC:HGNC:10680 See related Ensembl:ENSG00000073578 MIM:600857; AllianceGenome:HGNC:10680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FP; PGL5; SDH1; SDH2; SDHF; CMD1GG; MC2DN1; NDAXOA Summary This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] Expression Ubiquitous expression in heart (RPKM 63.7), kidney (RPKM 34.3) and 24 other tissues See more Orthologs mouse all
SDHAF1, Official Symbol SDHAF1provided by HGNC Official Full Name succinate dehydrogenase complex assembly factor 1provided by HGNC Primary source HGNC:HGNC:33867 See related Ensembl:ENSG00000205138 MIM:612848; AllianceGenome:HGNC:33867 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYRM8; MC2DN2 Summary The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010] Orthologs mouse all
SDHAF2, Official Symbol SDHAF2provided by HGNC Official Full Name succinate dehydrogenase complex assembly factor 2provided by HGNC Primary source HGNC:HGNC:26034 See related Ensembl:ENSG00000167985 MIM:613019; AllianceGenome:HGNC:26034 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGL2; SDH5; hSDH5; C11orf79 Summary This gene encodes a mitochondrial assembly factor needed for the flavination of a succinate dehydrogenase complex subunit (SDHA), which is required for activity of the succinate dehydrogenase complex. Mutations in this gene are associated with paraganglioma. [provided by RefSeq, May 2022] Expression Ubiquitous expression in lymph node (RPKM 19.3), adrenal (RPKM 17.1) and 25 other tissues See more Orthologs mouse all
SDHAF3, Official Symbol SDHAF3provided by HGNC Official Full Name succinate dehydrogenase complex assembly factor 3provided by HGNC Primary source HGNC:HGNC:21752 See related Ensembl:ENSG00000196636 MIM:615773; AllianceGenome:HGNC:21752 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACN9; DC11; Sdh7; LYRM10 Summary Predicted to be involved in mitochondrial respiratory chain complex II assembly; regulation of gluconeogenesis; and succinate metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 6.5), testis (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
SDHAF4, Official Symbol SDHAF4provided by HGNC Official Full Name succinate dehydrogenase complex assembly factor 4provided by HGNC Primary source HGNC:HGNC:20957 See related Ensembl:ENSG00000154079 MIM:619198; AllianceGenome:HGNC:20957 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Sdh8; C6orf57 Summary Predicted to enable enzyme activator activity. Involved in cellular respiration and mitochondrial respiratory chain complex II assembly. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 12.9), brain (RPKM 11.1) and 25 other tissues See more Orthologs mouse all
SDHAP2, Official Symbol SDHAP2provided by HGNC Official Full Name SDHA pseudogene 2provided by HGNC Primary source HGNC:HGNC:27408 See related Ensembl:ENSG00000242086 AllianceGenome:HGNC:27408 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDHAL2; SDHALP2 Expression Ubiquitous expression in endometrium (RPKM 12.3), testis (RPKM 12.1) and 25 other tissues See more
SDHB, Official Symbol SDHBprovided by HGNC Official Full Name succinate dehydrogenase complex iron sulfur subunit Bprovided by HGNC Primary source HGNC:HGNC:10681 See related Ensembl:ENSG00000117118 MIM:185470; AllianceGenome:HGNC:10681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP; MC2DN4 Summary This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency. [provided by RefSeq, Jun 2022] Expression Ubiquitous expression in heart (RPKM 84.5), kidney (RPKM 76.7) and 25 other tissues See more Orthologs mouse all
SDHC, Official Symbol SDHCprovided by HGNC Official Full Name succinate dehydrogenase complex subunit Cprovided by HGNC Primary source HGNC:HGNC:10682 See related Ensembl:ENSG00000143252 MIM:602413; AllianceGenome:HGNC:10682 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYBL; PGL3; QPS1; SDH3; CYB560 Summary This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013] Expression Ubiquitous expression in kidney (RPKM 80.5), liver (RPKM 66.7) and 25 other tissues See more Orthologs mouse all
SDHD, Official Symbol SDHDprovided by HGNC Official Full Name succinate dehydrogenase complex subunit Dprovided by HGNC Primary source HGNC:HGNC:10683 See related Ensembl:ENSG00000204370 MIM:602690; AllianceGenome:HGNC:10683 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGL; CBT1; CWS3; PGL1; QPs3; SDH4; cybS; CII-4; MC2DN3 Summary This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013] Expression Ubiquitous expression in kidney (RPKM 95.3), duodenum (RPKM 84.6) and 25 other tissues See more Orthologs mouse all
SDHDP1, Official Symbol SDHDP1provided by HGNC Official Full Name succinate dehydrogenase complex subunit D pseudogene 1provided by HGNC Primary source HGNC:HGNC:10684 See related AllianceGenome:HGNC:10684 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SDK1, Official Symbol SDK1provided by HGNC Official Full Name sidekick cell adhesion molecule 1provided by HGNC Primary source HGNC:HGNC:19307 See related Ensembl:ENSG00000146555 MIM:607216; AllianceGenome:HGNC:19307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016] Expression Broad expression in endometrium (RPKM 2.3), spleen (RPKM 2.1) and 22 other tissues See more Orthologs mouse all
SDK2, Official Symbol SDK2provided by HGNC Official Full Name sidekick cell adhesion molecule 2provided by HGNC Primary source HGNC:HGNC:19308 See related Ensembl:ENSG00000069188 MIM:607217; AllianceGenome:HGNC:19308 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 6.4), spleen (RPKM 1.7) and 8 other tissues See more Orthologs mouse all
SDR16C5, Official Symbol SDR16C5provided by HGNC Official Full Name short chain dehydrogenase/reductase family 16C member 5provided by HGNC Primary source HGNC:HGNC:30311 See related Ensembl:ENSG00000170786 MIM:608989; AllianceGenome:HGNC:30311 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDH#2; RDHE2; EPHD-2; RDH-E2; retSDR2 Summary This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in skin (RPKM 15.8), esophagus (RPKM 9.7) and 7 other tissues See more Orthologs all
SDR16C6P, Official Symbol SDR16C6Pprovided by HGNC Official Full Name short chain dehydrogenase/reductase family 16C member 6, pseudogeneprovided by HGNC Primary source HGNC:HGNC:35413 See related Ensembl:ENSG00000253542 AllianceGenome:HGNC:35413 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR16C6 Expression Low expression observed in reference dataset See more