psui3905/ncbi_genes_summary huggingface dataset:
CMTM6, Official Symbol CMTM6provided by HGNC Official Full Name CKLF like MARVEL transmembrane domain containing 6provided by HGNC Primary source HGNC:HGNC:19177 See related Ensembl:ENSG00000091317 MIM:607889; AllianceGenome:HGNC:19177 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKLFSF6; PRO2219 Summary This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in appendix (RPKM 47.3), thyroid (RPKM 44.1) and 25 other tissues See more Orthologs mouse all
CMTM7, Official Symbol CMTM7provided by HGNC Official Full Name CKLF like MARVEL transmembrane domain containing 7provided by HGNC Primary source HGNC:HGNC:19178 See related Ensembl:ENSG00000153551 MIM:607890; AllianceGenome:HGNC:19178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKLFSF7 Summary This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] Expression Broad expression in lymph node (RPKM 7.5), spleen (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
CMTM8, Official Symbol CMTM8provided by HGNC Official Full Name CKLF like MARVEL transmembrane domain containing 8provided by HGNC Primary source HGNC:HGNC:19179 See related Ensembl:ENSG00000170293 MIM:607891; AllianceGenome:HGNC:19179 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKLFSF8; CKLFSF8-V2 Summary This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] Expression Broad expression in liver (RPKM 5.0), lung (RPKM 5.0) and 23 other tissues See more Orthologs mouse all
CMTR1, Official Symbol CMTR1provided by HGNC Official Full Name cap methyltransferase 1provided by HGNC Primary source HGNC:HGNC:21077 See related Ensembl:ENSG00000137200 MIM:616189; AllianceGenome:HGNC:21077 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTr1; hMTr1; FTSJD2; KIAA0082 Summary Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and cap1 mRNA methylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 31.1), spleen (RPKM 12.4) and 25 other tissues See more Orthologs mouse all
CMTR2, Official Symbol CMTR2provided by HGNC Official Full Name cap methyltransferase 2provided by HGNC Primary source HGNC:HGNC:25635 See related Ensembl:ENSG00000180917 MIM:616190; AllianceGenome:HGNC:25635 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AFT; MTr2; HMTr2; FTSJD1 Summary Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and cap2 mRNA methylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.6), testis (RPKM 6.7) and 25 other tissues See more Orthologs mouse all
CMYA5, Official Symbol CMYA5provided by HGNC Official Full Name cardiomyopathy associated 5provided by HGNC Primary source HGNC:HGNC:14305 See related Ensembl:ENSG00000164309 MIM:612193; AllianceGenome:HGNC:14305 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPRYD2; TRIM76; C5orf10 Summary Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of calcineurin-NFAT signaling cascade; negative regulation of phosphoprotein phosphatase activity; and regulation of skeletal muscle adaptation. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in heart (RPKM 66.0), ovary (RPKM 8.5) and 3 other tissues See more Orthologs mouse all
CNBD1, Official Symbol CNBD1provided by HGNC Official Full Name cyclic nucleotide binding domain containing 1provided by HGNC Primary source HGNC:HGNC:26663 See related Ensembl:ENSG00000176571 AllianceGenome:HGNC:26663 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.9) See more Orthologs mouse all
CNBD2, Official Symbol CNBD2provided by HGNC Official Full Name cyclic nucleotide binding domain containing 2provided by HGNC Primary source HGNC:HGNC:16145 See related Ensembl:ENSG00000149646 AllianceGenome:HGNC:16145 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNMPD1; C20orf152 Summary Predicted to enable cAMP binding activity. Predicted to be involved in spermatogenesis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 3.5) and kidney (RPKM 0.1) See more Orthologs mouse all
CNBP, Official Symbol CNBPprovided by HGNC Official Full Name CCHC-type zinc finger nucleic acid binding proteinprovided by HGNC Primary source HGNC:HGNC:13164 See related Ensembl:ENSG00000169714 MIM:116955; AllianceGenome:HGNC:13164 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DM2; ZNF9; CNBP1; PROMM; RNF163; ZCCHC22 Summary This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in ovary (RPKM 93.4), heart (RPKM 89.1) and 25 other tissues See more Orthologs mouse all
CNDP1, Official Symbol CNDP1provided by HGNC Official Full Name carnosine dipeptidase 1provided by HGNC Primary source HGNC:HGNC:20675 See related Ensembl:ENSG00000150656 MIM:609064; AllianceGenome:HGNC:20675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CN1; CPGL2; HsT2308 Summary This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 44.8), liver (RPKM 24.2) and 1 other tissue See more Orthologs mouse all
CNDP2, Official Symbol CNDP2provided by HGNC Official Full Name carnosine dipeptidase 2provided by HGNC Primary source HGNC:HGNC:24437 See related Ensembl:ENSG00000133313 MIM:169800; AllianceGenome:HGNC:24437 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CN2; CPGL; PEPA; HsT2298; HEL-S-13 Summary CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in kidney (RPKM 58.4), small intestine (RPKM 41.5) and 24 other tissues See more Orthologs mouse all
CNEP1R1, Official Symbol CNEP1R1provided by HGNC Official Full Name CTD nuclear envelope phosphatase 1 regulatory subunit 1provided by HGNC Primary source HGNC:HGNC:26759 See related Ensembl:ENSG00000205423 MIM:616869; AllianceGenome:HGNC:26759 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEP1R1; TMP125; NEP1-R1; TMEM188; C16orf69 Summary This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in testis (RPKM 11.2), appendix (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
CNEP1R1P1, Official Symbol CNEP1R1P1provided by HGNC Official Full Name CNEP1R1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:55037 See related Ensembl:ENSG00000180284 AllianceGenome:HGNC:55037 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNFN, Official Symbol CNFNprovided by HGNC Official Full Name cornifelinprovided by HGNC Primary source HGNC:HGNC:30183 See related Ensembl:ENSG00000105427 MIM:611764; AllianceGenome:HGNC:30183 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLAC8L2 Summary Predicted to be involved in keratinization. Located in cornified envelope. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in esophagus (RPKM 174.2) and skin (RPKM 39.8) See more Orthologs mouse all
CNGA1, Official Symbol CNGA1provided by HGNC Official Full Name cyclic nucleotide gated channel subunit alpha 1provided by HGNC Primary source HGNC:HGNC:2148 See related Ensembl:ENSG00000198515 MIM:123825; AllianceGenome:HGNC:2148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha Summary The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Multiple transcript variants have been found for this gene. [provided by RefSeq, Oct 2019] Expression Broad expression in liver (RPKM 2.5), small intestine (RPKM 1.6) and 17 other tissues See more Orthologs mouse all
CNGA2, Official Symbol CNGA2provided by HGNC Official Full Name cyclic nucleotide gated channel subunit alpha 2provided by HGNC Primary source HGNC:HGNC:2149 See related Ensembl:ENSG00000183862 MIM:300338; AllianceGenome:HGNC:2149 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA Summary The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
CNGA3, Official Symbol CNGA3provided by HGNC Official Full Name cyclic nucleotide gated channel subunit alpha 3provided by HGNC Primary source HGNC:HGNC:2150 See related Ensembl:ENSG00000144191 MIM:600053; AllianceGenome:HGNC:2150 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNG3; ACHM2; CCNC1; CCNCa; CNCG3; CCNCalpha Summary This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
CNGA4, Official Symbol CNGA4provided by HGNC Official Full Name cyclic nucleotide gated channel subunit alpha 4provided by HGNC Primary source HGNC:HGNC:2152 See related Ensembl:ENSG00000132259 MIM:609472; AllianceGenome:HGNC:2152 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA Summary CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008] Expression Biased expression in testis (RPKM 2.8), lung (RPKM 0.7) and 3 other tissues See more Orthologs mouse all
CNGB1, Official Symbol CNGB1provided by HGNC Official Full Name cyclic nucleotide gated channel subunit beta 1provided by HGNC Primary source HGNC:HGNC:2151 See related Ensembl:ENSG00000070729 MIM:600724; AllianceGenome:HGNC:2151 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNG4; GAR1; GARP; RP45; CNCG2; CNCG4; GARP2; RCNC2; RCNCb; CNCG3L; CNGB1B; RCNCbeta Summary In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all
CNGB3, Official Symbol CNGB3provided by HGNC Official Full Name cyclic nucleotide gated channel subunit beta 3provided by HGNC Primary source HGNC:HGNC:2153 See related Ensembl:ENSG00000170289 MIM:605080; AllianceGenome:HGNC:2153 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACHM1 Summary This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010] Expression Biased expression in testis (RPKM 1.1), endometrium (RPKM 0.1) and 1 other tissue See more Orthologs mouse all
CNIH1, Official Symbol CNIH1provided by HGNC Official Full Name cornichon family AMPA receptor auxiliary protein 1provided by HGNC Primary source HGNC:HGNC:19431 See related Ensembl:ENSG00000100528 MIM:611287; AllianceGenome:HGNC:19431 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNIH; CNIL; CNIH-1; TGAM77 Summary Predicted to be involved in immune response and signal transduction. Predicted to be located in ER to Golgi transport vesicle membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in liver (RPKM 47.9), duodenum (RPKM 41.3) and 25 other tissues See more Orthologs mouse all
CNIH2, Official Symbol CNIH2provided by HGNC Official Full Name cornichon family AMPA receptor auxiliary protein 2provided by HGNC Primary source HGNC:HGNC:28744 See related Ensembl:ENSG00000174871 MIM:611288; AllianceGenome:HGNC:28744 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cnil; CNIH-2 Summary The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Biased expression in brain (RPKM 22.4), adrenal (RPKM 2.7) and 1 other tissue See more Orthologs mouse all
CNIH3, Official Symbol CNIH3provided by HGNC Official Full Name cornichon family AMPA receptor auxiliary protein 3provided by HGNC Primary source HGNC:HGNC:26802 See related Ensembl:ENSG00000143786 AllianceGenome:HGNC:26802 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNIH-3 Summary Predicted to enable channel regulator activity. Involved in regulation of AMPA receptor activity. Predicted to be located in dendritic shaft and postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendrite and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 4.8), testis (RPKM 1.6) and 10 other tissues See more Orthologs mouse all
CNIH4, Official Symbol CNIH4provided by HGNC Official Full Name cornichon family AMPA receptor auxiliary protein 4provided by HGNC Primary source HGNC:HGNC:25013 See related Ensembl:ENSG00000143771 MIM:617483; AllianceGenome:HGNC:25013 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNIH2; CNIH-4; HSPC163 Summary Enables CCR5 chemokine receptor binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 7.6), colon (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
CNKSR1, Official Symbol CNKSR1provided by HGNC Official Full Name connector enhancer of kinase suppressor of Ras 1provided by HGNC Primary source HGNC:HGNC:19700 See related Ensembl:ENSG00000142675 MIM:603272; AllianceGenome:HGNC:19700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNK; CNK1 Summary This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Broad expression in skin (RPKM 7.6), thyroid (RPKM 6.2) and 20 other tissues See more Orthologs mouse all
CNKSR2, Official Symbol CNKSR2provided by HGNC Official Full Name connector enhancer of kinase suppressor of Ras 2provided by HGNC Primary source HGNC:HGNC:19701 See related Ensembl:ENSG00000149970 MIM:300724; AllianceGenome:HGNC:19701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNK2; KSR2; MAGUIN; MRXSHG Summary This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Biased expression in brain (RPKM 9.7), adrenal (RPKM 1.3) and 2 other tissues See more Orthologs mouse all
CNKSR3, Official Symbol CNKSR3provided by HGNC Official Full Name CNKSR family member 3provided by HGNC Primary source HGNC:HGNC:23034 See related Ensembl:ENSG00000153721 MIM:617476; AllianceGenome:HGNC:23034 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNK3; MAGI1; CNK3/IPCEF1 Summary Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Predicted to act upstream of or within positive regulation of sodium ion transmembrane transporter activity. Predicted to be located in apical plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 6.3), kidney (RPKM 5.3) and 24 other tissues See more Orthologs mouse all
CNMD, Official Symbol CNMDprovided by HGNC Official Full Name chondromodulinprovided by HGNC Primary source HGNC:HGNC:17005 See related Ensembl:ENSG00000136110 MIM:605147; AllianceGenome:HGNC:17005 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHM1; CHM-I; LECT1; BRICD3; MYETS1 Summary This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in thyroid (RPKM 1.5), salivary gland (RPKM 1.3) and 3 other tissues See more Orthologs mouse all
CNN1, Official Symbol CNN1provided by HGNC Official Full Name calponin 1provided by HGNC Primary source HGNC:HGNC:2155 See related Ensembl:ENSG00000130176 MIM:600806; AllianceGenome:HGNC:2155 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMCC; Sm-Calp; HEL-S-14 Summary Predicted to enable actin binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in urinary bladder (RPKM 288.3), endometrium (RPKM 280.5) and 11 other tissues See more Orthologs mouse all
CNN2, Official Symbol CNN2provided by HGNC Official Full Name calponin 2provided by HGNC Primary source HGNC:HGNC:2156 See related Ensembl:ENSG00000064666 MIM:602373; AllianceGenome:HGNC:2156 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in lymph node (RPKM 70.8), appendix (RPKM 62.8) and 24 other tissues See more Orthologs mouse all
CNN2P10, Official Symbol CNN2P10provided by HGNC Official Full Name calponin 2 pseudogene 10provided by HGNC Primary source HGNC:HGNC:39535 See related Ensembl:ENSG00000232223 AllianceGenome:HGNC:39535 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNN2P6, Official Symbol CNN2P6provided by HGNC Official Full Name calponin 2 pseudogene 6provided by HGNC Primary source HGNC:HGNC:39531 See related Ensembl:ENSG00000213854 AllianceGenome:HGNC:39531 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNN2P9, Official Symbol CNN2P9provided by HGNC Official Full Name calponin 2 pseudogene 9provided by HGNC Primary source HGNC:HGNC:39534 See related AllianceGenome:HGNC:39534 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNN3, Official Symbol CNN3provided by HGNC Official Full Name calponin 3provided by HGNC Primary source HGNC:HGNC:2157 See related Ensembl:ENSG00000117519 MIM:602374; AllianceGenome:HGNC:2157 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 52.9), placenta (RPKM 49.2) and 24 other tissues See more Orthologs mouse all
CNNM1, Official Symbol CNNM1provided by HGNC Official Full Name cyclin and CBS domain divalent metal cation transport mediator 1provided by HGNC Primary source HGNC:HGNC:102 See related Ensembl:ENSG00000119946 MIM:607802; AllianceGenome:HGNC:102 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACDP1; CLP-1 Summary This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Biased expression in testis (RPKM 7.0), brain (RPKM 4.2) and 7 other tissues See more Orthologs mouse all
CNNM2, Official Symbol CNNM2provided by HGNC Official Full Name cyclin and CBS domain divalent metal cation transport mediator 2provided by HGNC Primary source HGNC:HGNC:103 See related Ensembl:ENSG00000148842 MIM:607803; AllianceGenome:HGNC:103 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACDP2; HOMG6; HOMGSMR Summary This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in kidney (RPKM 2.4), placenta (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
CNNM3, Official Symbol CNNM3provided by HGNC Official Full Name cyclin and CBS domain divalent metal cation transport mediator 3provided by HGNC Primary source HGNC:HGNC:104 See related Ensembl:ENSG00000168763 MIM:607804; AllianceGenome:HGNC:104 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACDP3 Summary Predicted to enable transmembrane transporter activity. Predicted to be involved in ion transport; magnesium ion homeostasis; and transmembrane transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 7.6), small intestine (RPKM 6.3) and 25 other tissues See more Orthologs mouse all
CNNM3-DT, Official Symbol CNNM3-DTprovided by HGNC Official Full Name CNNM3 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53592 See related Ensembl:ENSG00000273265 AllianceGenome:HGNC:53592 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in colon (RPKM 19.7), testis (RPKM 14.1) and 24 other tissues See more
CNNM4, Official Symbol CNNM4provided by HGNC Official Full Name cyclin and CBS domain divalent metal cation transport mediator 4provided by HGNC Primary source HGNC:HGNC:105 See related Ensembl:ENSG00000158158 MIM:607805; AllianceGenome:HGNC:105 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACDP4 Summary This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010] Expression Broad expression in colon (RPKM 26.1), thyroid (RPKM 9.4) and 23 other tissues See more Orthologs mouse all
CNOT1, Official Symbol CNOT1provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 1provided by HGNC Primary source HGNC:HGNC:7877 See related Ensembl:ENSG00000125107 MIM:604917; AllianceGenome:HGNC:7877 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOT1; CDC39; HPE12; NOT1H; VIBOS; AD-005 Summary Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in holoprosencephaly. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 56.3), esophagus (RPKM 28.6) and 25 other tissues See more Orthologs mouse all
CNOT10, Official Symbol CNOT10provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 10provided by HGNC Primary source HGNC:HGNC:23817 See related Ensembl:ENSG00000182973 AllianceGenome:HGNC:23817 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 18.8), thyroid (RPKM 7.6) and 24 other tissues See more Orthologs mouse all
CNOT10-AS1, Official Symbol CNOT10-AS1provided by HGNC Official Full Name CNOT10 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41031 See related AllianceGenome:HGNC:41031 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
CNOT11, Official Symbol CNOT11provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 11provided by HGNC Primary source HGNC:HGNC:25217 See related Ensembl:ENSG00000158435 AllianceGenome:HGNC:25217 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C40; C2orf29 Summary Predicted to be involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues See more Orthologs mouse all
CNOT2, Official Symbol CNOT2provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 2provided by HGNC Primary source HGNC:HGNC:7878 See related Ensembl:ENSG00000111596 MIM:604909; AllianceGenome:HGNC:7878 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOT2; CDC36; NOT2H; HSPC131; IDNADFS Summary This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in bone marrow (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues See more Orthologs mouse all
CNOT3, Official Symbol CNOT3provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 3provided by HGNC Primary source HGNC:HGNC:7879 See related Ensembl:ENSG00000088038 MIM:604910; AllianceGenome:HGNC:7879 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOT3; LENG2; NOT3H; IDDSADF Summary Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 13.9), spleen (RPKM 9.7) and 25 other tissues See more Orthologs mouse all
CNOT4, Official Symbol CNOT4provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 4provided by HGNC Primary source HGNC:HGNC:7880 See related Ensembl:ENSG00000080802 MIM:604911; AllianceGenome:HGNC:7880 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOT4; NOT4H; CLONE243 Summary The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] Expression Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
CNOT4P1, Official Symbol CNOT4P1provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39272 See related Ensembl:ENSG00000236704 AllianceGenome:HGNC:39272 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNOT6, Official Symbol CNOT6provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 6provided by HGNC Primary source HGNC:HGNC:14099 See related Ensembl:ENSG00000113300 MIM:608951; AllianceGenome:HGNC:14099 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCR4; Ccr4a Summary This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in testis (RPKM 8.0), urinary bladder (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
CNOT6L, Official Symbol CNOT6Lprovided by HGNC Official Full Name CCR4-NOT transcription complex subunit 6 likeprovided by HGNC Primary source HGNC:HGNC:18042 See related Ensembl:ENSG00000138767 MIM:618069; AllianceGenome:HGNC:18042 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCR4b Summary Predicted to enable poly(A)-specific ribonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
CNOT6LP1, Official Symbol CNOT6LP1provided by HGNC Official Full Name CNOT6L pseudogene 1provided by HGNC Primary source HGNC:HGNC:32355 See related AllianceGenome:HGNC:32355 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNOT7, Official Symbol CNOT7provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 7provided by HGNC Primary source HGNC:HGNC:14101 See related Ensembl:ENSG00000198791 MIM:604913; AllianceGenome:HGNC:14101 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAF1; CAF-1; Caf1a; hCAF-1 Summary The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues See more Orthologs mouse all
CNOT7P1, Official Symbol CNOT7P1provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 7 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44248 See related AllianceGenome:HGNC:44248 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNOT7P2, Official Symbol CNOT7P2provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 7 pseudogene 2provided by HGNC Primary source HGNC:HGNC:44249 See related AllianceGenome:HGNC:44249 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CNOT8, Official Symbol CNOT8provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 8provided by HGNC Primary source HGNC:HGNC:9207 See related Ensembl:ENSG00000155508 MIM:603731; AllianceGenome:HGNC:9207 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAF1; POP2; CALIF; Caf1b; hCAF1 Summary Enables poly(A)-specific ribonuclease activity. Involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 22.1), lymph node (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
CNOT9, Official Symbol CNOT9provided by HGNC Official Full Name CCR4-NOT transcription complex subunit 9provided by HGNC Primary source HGNC:HGNC:10445 See related Ensembl:ENSG00000144580 MIM:612054; AllianceGenome:HGNC:10445 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCD1; CAF40; CT129; RCD-1; RQCD1 Summary This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues See more Orthologs mouse all