psui3905/ncbi_genes_summary huggingface dataset:
CLDN1, Official Symbol CLDN1provided by HGNC Official Full Name claudin 1provided by HGNC Primary source HGNC:HGNC:2032 See related Ensembl:ENSG00000163347 MIM:603718; AllianceGenome:HGNC:2032 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLD1; SEMP1; ILVASC Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 138.8), liver (RPKM 107.2) and 6 other tissues See more Orthologs mouse all
CLDN10, Official Symbol CLDN10provided by HGNC Official Full Name claudin 10provided by HGNC Primary source HGNC:HGNC:2033 See related Ensembl:ENSG00000134873 MIM:617579; AllianceGenome:HGNC:2033 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSPL; HELIX; OSP-L; CPETRL3 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010] Expression Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues See more Orthologs mouse all
CLDN10-AS1, Official Symbol CLDN10-AS1provided by HGNC Official Full Name CLDN10 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39907 See related Ensembl:ENSG00000223392 AllianceGenome:HGNC:39907 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in salivary gland (RPKM 1.9), kidney (RPKM 0.6) and 1 other tissue See more
CLDN11, Official Symbol CLDN11provided by HGNC Official Full Name claudin 11provided by HGNC Primary source HGNC:HGNC:8514 See related Ensembl:ENSG00000013297 MIM:601326; AllianceGenome:HGNC:8514 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSP; OTM; HLD22 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010] Expression Biased expression in testis (RPKM 84.9), brain (RPKM 41.6) and 2 other tissues See more Orthologs mouse all
CLDN12, Official Symbol CLDN12provided by HGNC Official Full Name claudin 12provided by HGNC Primary source HGNC:HGNC:2034 See related Ensembl:ENSG00000157224 MIM:611232; AllianceGenome:HGNC:2034 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011] Expression Ubiquitous expression in colon (RPKM 15.9), prostate (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
CLDN14, Official Symbol CLDN14provided by HGNC Official Full Name claudin 14provided by HGNC Primary source HGNC:HGNC:2035 See related Ensembl:ENSG00000159261 MIM:605608; AllianceGenome:HGNC:2035 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB29 Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010] Expression Biased expression in liver (RPKM 3.1) and kidney (RPKM 1.4) See more Orthologs mouse all
CLDN15, Official Symbol CLDN15provided by HGNC Official Full Name claudin 15provided by HGNC Primary source HGNC:HGNC:2036 See related Ensembl:ENSG00000106404 MIM:615778; AllianceGenome:HGNC:2036 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010] Expression Biased expression in duodenum (RPKM 65.8), small intestine (RPKM 50.2) and 8 other tissues See more Orthologs mouse all
CLDN16, Official Symbol CLDN16provided by HGNC Official Full Name claudin 16provided by HGNC Primary source HGNC:HGNC:2037 See related Ensembl:ENSG00000113946 MIM:603959; AllianceGenome:HGNC:2037 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOMG3; PCLN1 Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010] Expression Biased expression in kidney (RPKM 20.4), thyroid (RPKM 4.2) and 1 other tissue See more Orthologs mouse all
CLDN17, Official Symbol CLDN17provided by HGNC Official Full Name claudin 17provided by HGNC Primary source HGNC:HGNC:2038 See related Ensembl:ENSG00000156282 MIM:617005; AllianceGenome:HGNC:2038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010] Orthologs mouse all
CLDN18, Official Symbol CLDN18provided by HGNC Official Full Name claudin 18provided by HGNC Primary source HGNC:HGNC:2039 See related Ensembl:ENSG00000066405 MIM:609210; AllianceGenome:HGNC:2039 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFTA5; SFTPJ Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010] Expression Biased expression in stomach (RPKM 335.4) and lung (RPKM 153.8) See more Orthologs mouse all
CLDN19, Official Symbol CLDN19provided by HGNC Official Full Name claudin 19provided by HGNC Primary source HGNC:HGNC:2040 See related Ensembl:ENSG00000164007 MIM:610036; AllianceGenome:HGNC:2040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOMG5 Summary The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010] Expression Biased expression in kidney (RPKM 11.6) and placenta (RPKM 4.9) See more Orthologs mouse all
CLDN2, Official Symbol CLDN2provided by HGNC Official Full Name claudin 2provided by HGNC Primary source HGNC:HGNC:2041 See related Ensembl:ENSG00000165376 MIM:300520; AllianceGenome:HGNC:2041 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OAZON; claudin-2 Summary This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010] Expression Biased expression in kidney (RPKM 67.4), gall bladder (RPKM 59.4) and 4 other tissues See more Orthologs mouse all
CLDN20, Official Symbol CLDN20provided by HGNC Official Full Name claudin 20provided by HGNC Primary source HGNC:HGNC:2042 See related Ensembl:ENSG00000171217 AllianceGenome:HGNC:2042 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
CLDN22, Official Symbol CLDN22provided by HGNC Official Full Name claudin 22provided by HGNC Primary source HGNC:HGNC:2044 See related Ensembl:ENSG00000177300 AllianceGenome:HGNC:2044 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLDN21 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010] Orthologs all
CLDN23, Official Symbol CLDN23provided by HGNC Official Full Name claudin 23provided by HGNC Primary source HGNC:HGNC:17591 See related Ensembl:ENSG00000253958 MIM:609203; AllianceGenome:HGNC:17591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLDNL; hCG1646163 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010] Orthologs mouse all
CLDN24, Official Symbol CLDN24provided by HGNC Official Full Name claudin 24provided by HGNC Primary source HGNC:HGNC:37200 See related Ensembl:ENSG00000185758 AllianceGenome:HGNC:37200 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLDN21 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in the genome.[provided by RefSeq, Aug 2010] Orthologs all
CLDN25, Official Symbol CLDN25provided by HGNC Official Full Name claudin 25provided by HGNC Primary source HGNC:HGNC:37218 See related Ensembl:ENSG00000228607 AllianceGenome:HGNC:37218 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010] Orthologs mouse all
CLDN3, Official Symbol CLDN3provided by HGNC Official Full Name claudin 3provided by HGNC Primary source HGNC:HGNC:2045 See related Ensembl:ENSG00000165215 MIM:602910; AllianceGenome:HGNC:2045 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RVP1; HRVP1; C7orf1; CPE-R2; CPETR2 Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008] Orthologs mouse all
CLDN34, Official Symbol CLDN34provided by HGNC Official Full Name claudin 34provided by HGNC Primary source HGNC:HGNC:51259 See related Ensembl:ENSG00000234469 AllianceGenome:HGNC:51259 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be integral component of membrane. Predicted to be active in bicellular tight junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
CLDN4, Official Symbol CLDN4provided by HGNC Official Full Name claudin 4provided by HGNC Primary source HGNC:HGNC:2046 See related Ensembl:ENSG00000189143 MIM:602909; AllianceGenome:HGNC:2046 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R Summary The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013] Orthologs mouse all
CLDN5, Official Symbol CLDN5provided by HGNC Official Full Name claudin 5provided by HGNC Primary source HGNC:HGNC:2047 See related Ensembl:ENSG00000184113 MIM:602101; AllianceGenome:HGNC:2047 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AWAL; BEC1; TMVCF; TMDVCF; CPETRL1 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018] Expression Biased expression in fat (RPKM 51.6), lung (RPKM 14.0) and 6 other tissues See more Orthologs mouse all
CLDN6, Official Symbol CLDN6provided by HGNC Official Full Name claudin 6provided by HGNC Primary source HGNC:HGNC:2048 See related Ensembl:ENSG00000184697 MIM:615798; AllianceGenome:HGNC:2048 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
CLDN7, Official Symbol CLDN7provided by HGNC Official Full Name claudin 7provided by HGNC Primary source HGNC:HGNC:2049 See related Ensembl:ENSG00000181885 MIM:609131; AllianceGenome:HGNC:2049 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] Expression Biased expression in colon (RPKM 107.5), small intestine (RPKM 93.5) and 12 other tissues See more Orthologs mouse all
CLDN8, Official Symbol CLDN8provided by HGNC Official Full Name claudin 8provided by HGNC Primary source HGNC:HGNC:2050 See related Ensembl:ENSG00000156284 MIM:611231; AllianceGenome:HGNC:2050 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEL-S-79 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010] Orthologs mouse all
CLDN9, Official Symbol CLDN9provided by HGNC Official Full Name claudin 9provided by HGNC Primary source HGNC:HGNC:2051 See related Ensembl:ENSG00000213937 MIM:615799; AllianceGenome:HGNC:2051 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB116 Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010] Orthologs mouse all
CLDND1, Official Symbol CLDND1provided by HGNC Official Full Name claudin domain containing 1provided by HGNC Primary source HGNC:HGNC:1322 See related Ensembl:ENSG00000080822 MIM:619677; AllianceGenome:HGNC:1322 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Z38; C3orf4; GENX-3745 Summary Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 128.7), testis (RPKM 51.4) and 23 other tissues See more Orthologs mouse all
CLDND2, Official Symbol CLDND2provided by HGNC Official Full Name claudin domain containing 2provided by HGNC Primary source HGNC:HGNC:28511 See related Ensembl:ENSG00000160318 AllianceGenome:HGNC:28511 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 2.4), bone marrow (RPKM 0.9) and 19 other tissues See more Orthologs mouse all
CLEC10A, Official Symbol CLEC10Aprovided by HGNC Official Full Name C-type lectin domain containing 10Aprovided by HGNC Primary source HGNC:HGNC:16916 See related Ensembl:ENSG00000132514 MIM:605999; AllianceGenome:HGNC:16916 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HML; MGL; HML2; CD301; CLECSF13; CLECSF14 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 13.9), small intestine (RPKM 10.3) and 21 other tissues See more Orthologs all
CLEC11A, Official Symbol CLEC11Aprovided by HGNC Official Full Name C-type lectin domain containing 11Aprovided by HGNC Primary source HGNC:HGNC:10576 See related Ensembl:ENSG00000105472 MIM:604713; AllianceGenome:HGNC:10576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P47; SCGF; LSLCL; CLECSF3 Summary This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 36.6), endometrium (RPKM 6.5) and 15 other tissues See more Orthologs mouse all
CLEC12A, Official Symbol CLEC12Aprovided by HGNC Official Full Name C-type lectin domain family 12 member Aprovided by HGNC Primary source HGNC:HGNC:31713 See related Ensembl:ENSG00000172322 MIM:612088; AllianceGenome:HGNC:31713 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLL1; MICL; CD371; CLL-1; DCAL-2 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011] Expression Biased expression in bone marrow (RPKM 14.2), appendix (RPKM 4.4) and 7 other tissues See more Orthologs mouse all
CLEC12A-AS1, Official Symbol CLEC12A-AS1provided by HGNC Official Full Name CLEC12A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53407 See related Ensembl:ENSG00000231560 AllianceGenome:HGNC:53407 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
CLEC12B, Official Symbol CLEC12Bprovided by HGNC Official Full Name C-type lectin domain family 12 member Bprovided by HGNC Primary source HGNC:HGNC:31966 See related Ensembl:ENSG00000256660 MIM:617573; AllianceGenome:HGNC:31966 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNQ5782 Summary Enables protein phosphatase binding activity and signaling receptor inhibitor activity. Involved in natural killer cell inhibitory signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and negative regulation of signaling receptor activity. Located in external side of plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 8.0), skin (RPKM 1.6) and 1 other tissue See more Orthologs mouse all
CLEC14A, Official Symbol CLEC14Aprovided by HGNC Official Full Name C-type lectin domain containing 14Aprovided by HGNC Primary source HGNC:HGNC:19832 See related Ensembl:ENSG00000176435 MIM:616845; AllianceGenome:HGNC:19832 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEG1; EGFR-5; C14orf27 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012] Orthologs mouse all
CLEC16A, Official Symbol CLEC16Aprovided by HGNC Official Full Name C-type lectin domain containing 16Aprovided by HGNC Primary source HGNC:HGNC:29013 See related Ensembl:ENSG00000038532 MIM:611303; AllianceGenome:HGNC:29013 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gop-1; KIAA0350 Summary This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 11.3), brain (RPKM 3.5) and 24 other tissues See more Orthologs mouse all
CLEC17A, Official Symbol CLEC17Aprovided by HGNC Official Full Name C-type lectin domain containing 17Aprovided by HGNC Primary source HGNC:HGNC:34520 See related Ensembl:ENSG00000187912 MIM:616838; AllianceGenome:HGNC:34520 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables fucose binding activity; identical protein binding activity; and mannose binding activity. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 5.2), spleen (RPKM 3.9) and 4 other tissues See more Orthologs all
CLEC18A, Official Symbol CLEC18Aprovided by HGNC Official Full Name C-type lectin domain family 18 member Aprovided by HGNC Primary source HGNC:HGNC:30388 See related Ensembl:ENSG00000157322 MIM:616571; AllianceGenome:HGNC:30388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRCL; MRCL1; MRLP2 Summary This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012] Expression Biased expression in kidney (RPKM 14.8), testis (RPKM 4.0) and 1 other tissue See more Orthologs all
CLEC18B, Official Symbol CLEC18Bprovided by HGNC Official Full Name C-type lectin domain family 18 member Bprovided by HGNC Primary source HGNC:HGNC:33849 See related Ensembl:ENSG00000140839 MIM:616572; AllianceGenome:HGNC:33849 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRCL2 Summary Predicted to enable polysaccharide binding activity. Predicted to be located in Golgi apparatus; endosome; and sarcoplasmic reticulum. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 34.8) and testis (RPKM 8.2) See more Orthologs all
CLEC18C, Official Symbol CLEC18Cprovided by HGNC Official Full Name C-type lectin domain family 18 member Cprovided by HGNC Primary source HGNC:HGNC:28538 See related Ensembl:ENSG00000157335 MIM:616573; AllianceGenome:HGNC:28538 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRCL; MRCL3 Summary Enables polysaccharide binding activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endosome. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 27.4) and testis (RPKM 7.1) See more Orthologs all
CLEC19A, Official Symbol CLEC19Aprovided by HGNC Official Full Name C-type lectin domain containing 19Aprovided by HGNC Primary source HGNC:HGNC:34522 See related Ensembl:ENSG00000261210 AllianceGenome:HGNC:34522 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
CLEC1A, Official Symbol CLEC1Aprovided by HGNC Official Full Name C-type lectin domain family 1 member Aprovided by HGNC Primary source HGNC:HGNC:24355 See related Ensembl:ENSG00000150048 MIM:606782; AllianceGenome:HGNC:24355 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLEC1; CLEC-1 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Biased expression in placenta (RPKM 18.1), lung (RPKM 3.8) and 10 other tissues See more Orthologs mouse all
CLEC1B, Official Symbol CLEC1Bprovided by HGNC Official Full Name C-type lectin domain family 1 member Bprovided by HGNC Primary source HGNC:HGNC:24356 See related Ensembl:ENSG00000165682 MIM:606783; AllianceGenome:HGNC:24356 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik Summary Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] Expression Biased expression in liver (RPKM 4.2), bone marrow (RPKM 0.6) and 1 other tissue See more Orthologs mouse all
CLEC20A, Official Symbol CLEC20Aprovided by HGNC Official Full Name C-type lectin domain containing 20Aprovided by HGNC Primary source HGNC:HGNC:34521 See related Ensembl:ENSG00000188585 AllianceGenome:HGNC:34521 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00083; NCRNA00083 Summary Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 2.0), lymph node (RPKM 0.7) and 14 other tissues See more Orthologs all
CLEC2A, Official Symbol CLEC2Aprovided by HGNC Official Full Name C-type lectin domain family 2 member Aprovided by HGNC Primary source HGNC:HGNC:24191 See related Ensembl:ENSG00000188393 MIM:612087; AllianceGenome:HGNC:24191 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KACL; PILAR; UNQ5792; INPE5792 Summary Enables protein homodimerization activity. Predicted to be involved in natural killer cell mediated cytotoxicity. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; regulation of actin filament polymerization; and regulation of interleukin-2 production. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward skin (RPKM 6.7) See more Orthologs all
CLEC2B, Official Symbol CLEC2Bprovided by HGNC Official Full Name C-type lectin domain family 2 member Bprovided by HGNC Primary source HGNC:HGNC:2053 See related Ensembl:ENSG00000110852 MIM:603242; AllianceGenome:HGNC:2053 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AICL; IFNRG1; CLECSF2; HP10085 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] Expression Broad expression in skin (RPKM 19.0), bone marrow (RPKM 18.7) and 22 other tissues See more Orthologs all
CLEC2D, Official Symbol CLEC2Dprovided by HGNC Official Full Name C-type lectin domain family 2 member Dprovided by HGNC Primary source HGNC:HGNC:14351 See related Ensembl:ENSG00000069493 MIM:605659; AllianceGenome:HGNC:14351 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLAX; LLT1; OCIL Summary This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010] Expression Broad expression in lymph node (RPKM 24.3), appendix (RPKM 12.2) and 24 other tissues See more Orthologs all
CLEC2L, Official Symbol CLEC2Lprovided by HGNC Official Full Name C-type lectin domain family 2 member Lprovided by HGNC Primary source HGNC:HGNC:21969 See related Ensembl:ENSG00000236279 AllianceGenome:HGNC:21969 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable carbohydrate binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 5.6), endometrium (RPKM 0.5) and 1 other tissue See more Orthologs mouse all