psui3905/ncbi_genes_summary huggingface dataset:
ARMH3, Official Symbol ARMH3provided by HGNC Official Full Name armadillo like helical domain containing 3provided by HGNC Primary source HGNC:HGNC:25788 See related Ensembl:ENSG00000120029 AllianceGenome:HGNC:25788 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C10orf76 Summary Involved in regulation of Golgi organization. Located in Golgi membrane and cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 8.1), esophagus (RPKM 4.9) and 25 other tissues See more Orthologs mouse all
ARMH4, Official Symbol ARMH4provided by HGNC Official Full Name armadillo like helical domain containing 4provided by HGNC Primary source HGNC:HGNC:19846 See related Ensembl:ENSG00000139971 AllianceGenome:HGNC:19846 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UT2; C14orf37; c14_5376 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 5.3), brain (RPKM 4.3) and 15 other tissues See more Orthologs mouse all
ARMS2, Official Symbol ARMS2provided by HGNC Official Full Name age-related maculopathy susceptibility 2provided by HGNC Primary source HGNC:HGNC:32685 See related Ensembl:ENSG00000254636 MIM:611313; AllianceGenome:HGNC:32685 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARMD8 Summary This gene encodes a small secreted protein specific to primates. This protein is a component of the choroidal extracellular matrix of the eye. Mutations in this gene are associated with age-related macular degeneration. [provided by RefSeq, Sep 2017] Expression Biased expression in testis (RPKM 1.0), placenta (RPKM 1.0) and 6 other tissues See more Orthologs all
ARMT1, Official Symbol ARMT1provided by HGNC Official Full Name acidic residue methyltransferase 1provided by HGNC Primary source HGNC:HGNC:17872 See related Ensembl:ENSG00000146476 MIM:616332; AllianceGenome:HGNC:17872 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6orf211 Summary Enables S-adenosylmethionine-dependent methyltransferase activity; enzyme binding activity; and protein carboxyl O-methyltransferase activity. Involved in methylation and regulation of response to DNA damage stimulus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 18.3), kidney (RPKM 17.3) and 24 other tissues See more Orthologs mouse all
ARNILA, Official Symbol ARNILAprovided by HGNC Official Full Name androgen receptor negatively regulated lncRNAprovided by HGNC Primary source HGNC:HGNC:54484 See related AllianceGenome:HGNC:54484 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
ARNT, Official Symbol ARNTprovided by HGNC Official Full Name aryl hydrocarbon receptor nuclear translocatorprovided by HGNC Primary source HGNC:HGNC:700 See related Ensembl:ENSG00000143437 MIM:126110; AllianceGenome:HGNC:700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARNT1; HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta Summary This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] Expression Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues See more Orthologs mouse all
ARNT2, Official Symbol ARNT2provided by HGNC Official Full Name aryl hydrocarbon receptor nuclear translocator 2provided by HGNC Primary source HGNC:HGNC:16876 See related Ensembl:ENSG00000172379 MIM:606036; AllianceGenome:HGNC:16876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WEDAS; bHLHe1 Summary This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013] Expression Biased expression in brain (RPKM 65.1), kidney (RPKM 9.7) and 5 other tissues See more Orthologs mouse all
ARPC1A, Official Symbol ARPC1Aprovided by HGNC Official Full Name actin related protein 2/3 complex subunit 1Aprovided by HGNC Primary source HGNC:HGNC:703 See related Ensembl:ENSG00000241685 MIM:604220; AllianceGenome:HGNC:703 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Arc40; SOP2L; HEL-68; SOP2Hs; HEL-S-307 Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in thyroid (RPKM 48.9), stomach (RPKM 46.5) and 25 other tissues See more Orthologs mouse all
ARPC1B, Official Symbol ARPC1Bprovided by HGNC Official Full Name actin related protein 2/3 complex subunit 1Bprovided by HGNC Primary source HGNC:HGNC:704 See related Ensembl:ENSG00000130429 MIM:604223; AllianceGenome:HGNC:704 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC41; IMD71; PLTEID; p40-ARC; p41-ARC Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011] Expression Broad expression in spleen (RPKM 111.2), appendix (RPKM 92.6) and 24 other tissues See more Orthologs mouse all
ARPC1BP1, Official Symbol ARPC1BP1provided by HGNC Official Full Name ARPC1B pseudogene 1provided by HGNC Primary source HGNC:HGNC:54638 See related Ensembl:ENSG00000213081 AllianceGenome:HGNC:54638 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ARPC2, Official Symbol ARPC2provided by HGNC Official Full Name actin related protein 2/3 complex subunit 2provided by HGNC Primary source HGNC:HGNC:705 See related Ensembl:ENSG00000163466 MIM:604224; AllianceGenome:HGNC:705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC34; PRO2446; p34-Arc; PNAS-139 Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 92.4), bone marrow (RPKM 89.6) and 25 other tissues See more Orthologs mouse all
ARPC3, Official Symbol ARPC3provided by HGNC Official Full Name actin related protein 2/3 complex subunit 3provided by HGNC Primary source HGNC:HGNC:706 See related Ensembl:ENSG00000111229 MIM:604225; AllianceGenome:HGNC:706 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC21; p21-Arc Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] Expression Ubiquitous expression in lymph node (RPKM 232.8), bone marrow (RPKM 231.9) and 25 other tissues See more Orthologs mouse all
ARPC3P5, Official Symbol ARPC3P5provided by HGNC Official Full Name actin related protein 2/3 complex subunit 3 pseudogene 5provided by HGNC Primary source HGNC:HGNC:39435 See related AllianceGenome:HGNC:39435 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ARPC4, Official Symbol ARPC4provided by HGNC Official Full Name actin related protein 2/3 complex subunit 4provided by HGNC Primary source HGNC:HGNC:707 See related Ensembl:ENSG00000241553 MIM:604226; AllianceGenome:HGNC:707 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC20; DEVLO; P20-ARC Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in lymph node (RPKM 63.0), appendix (RPKM 61.6) and 25 other tissues See more Orthologs mouse all
ARPC4-TTLL3, Official Symbol ARPC4-TTLL3provided by HGNC Official Full Name ARPC4-TTLL3 readthroughprovided by HGNC Primary source HGNC:HGNC:38830 See related Ensembl:ENSG00000250151 AllianceGenome:HGNC:38830 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC20; ARPC4; p20-ARC Summary This locus represents naturally occurring read-through transcription between the neighboring ARPC4 (actin related protein 2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like family, member 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in lymph node (RPKM 18.9), bone marrow (RPKM 17.8) and 25 other tissues See more Orthologs all
ARPC5, Official Symbol ARPC5provided by HGNC Official Full Name actin related protein 2/3 complex subunit 5provided by HGNC Primary source HGNC:HGNC:708 See related Ensembl:ENSG00000162704 MIM:604227; AllianceGenome:HGNC:708 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC16; p16-Arc; dJ127C7.3 Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in lymph node (RPKM 104.2), appendix (RPKM 91.8) and 25 other tissues See more Orthologs mouse all
ARPC5L, Official Symbol ARPC5Lprovided by HGNC Official Full Name actin related protein 2/3 complex subunit 5 likeprovided by HGNC Primary source HGNC:HGNC:23366 See related Ensembl:ENSG00000136950 AllianceGenome:HGNC:23366 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC16-2 Summary Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
ARPIN, Official Symbol ARPINprovided by HGNC Official Full Name actin related protein 2/3 complex inhibitorprovided by HGNC Primary source HGNC:HGNC:28782 See related Ensembl:ENSG00000242498 MIM:615543; AllianceGenome:HGNC:28782 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C15orf38 Summary Involved in directional locomotion; negative regulation of cell migration; and negative regulation of cellular component organization. Predicted to be located in lamellipodium. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 5.0), ovary (RPKM 4.4) and 24 other tissues See more Orthologs mouse all
ARPIN-AP3S2, Official Symbol ARPIN-AP3S2provided by HGNC Official Full Name ARPIN-AP3S2 readthroughprovided by HGNC Primary source HGNC:HGNC:38824 See related Ensembl:ENSG00000250021 AllianceGenome:HGNC:38824 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARPIN; C15orf38; C15orf38-AP3S2 Summary This locus represents naturally occurring read-through transcription between the neighboring C15orf38 (chromosome 15 open reading frame 38) and AP3S2 (adaptor-related protein complex 3, sigma 2 subunit) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in kidney (RPKM 10.5), brain (RPKM 9.9) and 25 other tissues See more Orthologs all
ARPP19, Official Symbol ARPP19provided by HGNC Official Full Name cAMP regulated phosphoprotein 19provided by HGNC Primary source HGNC:HGNC:16967 See related Ensembl:ENSG00000128989 MIM:605487; AllianceGenome:HGNC:16967 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ENSAL; ARPP16; ARPP-16; ARPP-19 Summary The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011] Expression Ubiquitous expression in brain (RPKM 79.8), thyroid (RPKM 29.3) and 24 other tissues See more Orthologs mouse all
ARPP19P1, Official Symbol ARPP19P1provided by HGNC Official Full Name ARPP19 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54698 See related AllianceGenome:HGNC:54698 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ARPP21, Official Symbol ARPP21provided by HGNC Official Full Name cAMP regulated phosphoprotein 21provided by HGNC Primary source HGNC:HGNC:16968 See related Ensembl:ENSG00000172995 MIM:605488; AllianceGenome:HGNC:16968 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCS; TARPP; R3HDM3; ARPP-21 Summary This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Expression Biased expression in brain (RPKM 4.3) and esophagus (RPKM 0.1) See more Orthologs mouse all
ARPP21-AS1, Official Symbol ARPP21-AS1provided by HGNC Official Full Name ARPP21 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40785 See related AllianceGenome:HGNC:40785 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
ARR3, Official Symbol ARR3provided by HGNC Official Full Name arrestin 3provided by HGNC Primary source HGNC:HGNC:710 See related Ensembl:ENSG00000120500 MIM:301770; AllianceGenome:HGNC:710 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARRX; cArr; MYP26 Summary The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016] Expression Low expression observed in reference dataset See more Orthologs mouse all
ARRB1, Official Symbol ARRB1provided by HGNC Official Full Name arrestin beta 1provided by HGNC Primary source HGNC:HGNC:711 See related Ensembl:ENSG00000137486 MIM:107940; AllianceGenome:HGNC:711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARB1; ARR1 Summary Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011] Expression Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues See more Orthologs mouse all
ARRB2, Official Symbol ARRB2provided by HGNC Official Full Name arrestin beta 2provided by HGNC Primary source HGNC:HGNC:712 See related Ensembl:ENSG00000141480 MIM:107941; AllianceGenome:HGNC:712 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARB2; ARR2; BARR2 Summary Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] Expression Broad expression in bone marrow (RPKM 69.2), appendix (RPKM 43.9) and 21 other tissues See more Orthologs mouse all
ARRDC1, Official Symbol ARRDC1provided by HGNC Official Full Name arrestin domain containing 1provided by HGNC Primary source HGNC:HGNC:28633 See related Ensembl:ENSG00000197070 MIM:619768; AllianceGenome:HGNC:28633 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables several functions, including arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular protein metabolic process; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in stomach (RPKM 15.2), spleen (RPKM 13.5) and 25 other tissues See more Orthologs mouse all
ARRDC1-AS1, Official Symbol ARRDC1-AS1provided by HGNC Official Full Name ARRDC1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:23395 See related Ensembl:ENSG00000203993 AllianceGenome:HGNC:23395 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C9orf37 Summary This transcribed locus is thought to be non-coding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Ubiquitous expression in testis (RPKM 5.9), prostate (RPKM 5.0) and 25 other tissues See more
ARRDC2, Official Symbol ARRDC2provided by HGNC Official Full Name arrestin domain containing 2provided by HGNC Primary source HGNC:HGNC:25225 See related Ensembl:ENSG00000105643 AllianceGenome:HGNC:25225 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2703; CLONE24945 Summary Predicted to be involved in protein transport. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 25.3), fat (RPKM 16.5) and 24 other tissues See more Orthologs mouse all
ARRDC3, Official Symbol ARRDC3provided by HGNC Official Full Name arrestin domain containing 3provided by HGNC Primary source HGNC:HGNC:29263 See related Ensembl:ENSG00000113369 MIM:612464; AllianceGenome:HGNC:29263 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLIMP Summary This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in bone marrow (RPKM 76.9), thyroid (RPKM 64.6) and 24 other tissues See more Orthologs mouse all
ARRDC3-AS1, Official Symbol ARRDC3-AS1provided by HGNC Official Full Name ARRDC3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44145 See related Ensembl:ENSG00000281357 AllianceGenome:HGNC:44145 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 1.5), bone marrow (RPKM 0.6) and 23 other tissues See more
ARRDC4, Official Symbol ARRDC4provided by HGNC Official Full Name arrestin domain containing 4provided by HGNC Primary source HGNC:HGNC:28087 See related Ensembl:ENSG00000140450 MIM:619788; AllianceGenome:HGNC:28087 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
ARRDC5, Official Symbol ARRDC5provided by HGNC Official Full Name arrestin domain containing 5provided by HGNC Primary source HGNC:HGNC:31407 See related Ensembl:ENSG00000205784 AllianceGenome:HGNC:31407 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 6.0), spleen (RPKM 1.1) and 12 other tissues See more Orthologs mouse all
ARSA, Official Symbol ARSAprovided by HGNC Official Full Name arylsulfatase Aprovided by HGNC Primary source HGNC:HGNC:713 See related Ensembl:ENSG00000100299 MIM:607574; AllianceGenome:HGNC:713 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASA; MLD Summary The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in testis (RPKM 9.9), spleen (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
ARSB, Official Symbol ARSBprovided by HGNC Official Full Name arylsulfatase Bprovided by HGNC Primary source HGNC:HGNC:714 See related Ensembl:ENSG00000113273 MIM:611542; AllianceGenome:HGNC:714 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASB; G4S; MPS6 Summary Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in kidney (RPKM 2.5), placenta (RPKM 1.5) and 25 other tissues See more Orthologs mouse all
ARSD, Official Symbol ARSDprovided by HGNC Official Full Name arylsulfatase Dprovided by HGNC Primary source HGNC:HGNC:717 See related Ensembl:ENSG00000006756 MIM:300002; AllianceGenome:HGNC:717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASD Summary The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011] Expression Ubiquitous expression in kidney (RPKM 21.5), thyroid (RPKM 12.5) and 25 other tissues See more Orthologs all
ARSD-AS1, Official Symbol ARSD-AS1provided by HGNC Official Full Name ARSD antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40085 See related Ensembl:ENSG00000229851 AllianceGenome:HGNC:40085 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ARSF, Official Symbol ARSFprovided by HGNC Official Full Name arylsulfatase Fprovided by HGNC Primary source HGNC:HGNC:721 See related Ensembl:ENSG00000062096 MIM:300003; AllianceGenome:HGNC:721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASF Summary This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011] Expression Biased expression in kidney (RPKM 3.3), skin (RPKM 2.1) and 5 other tissues See more Orthologs all
ARSFP1, Official Symbol ARSFP1provided by HGNC Official Full Name arylsulfatase F pseudogene 1provided by HGNC Primary source HGNC:HGNC:722 See related Ensembl:ENSG00000232226 AllianceGenome:HGNC:722 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARSFP
ARSG, Official Symbol ARSGprovided by HGNC Official Full Name arylsulfatase Gprovided by HGNC Primary source HGNC:HGNC:24102 See related Ensembl:ENSG00000141337 MIM:610008; AllianceGenome:HGNC:24102 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USH4 Summary The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012] Annotation information Annotation category: suggests misassembly Expression Ubiquitous expression in thyroid (RPKM 2.8), placenta (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
ARSH, Official Symbol ARSHprovided by HGNC Official Full Name arylsulfatase family member Hprovided by HGNC Primary source HGNC:HGNC:32488 See related Ensembl:ENSG00000205667 MIM:300586; AllianceGenome:HGNC:32488 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as sulfatase Summary Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008] Expression Low expression observed in reference dataset See more Orthologs all
ARSI, Official Symbol ARSIprovided by HGNC Official Full Name arylsulfatase family member Iprovided by HGNC Primary source HGNC:HGNC:32521 See related Ensembl:ENSG00000183876 MIM:610009; AllianceGenome:HGNC:32521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASI; SPG66 Summary This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016] Expression Broad expression in skin (RPKM 1.9), placenta (RPKM 1.8) and 20 other tissues See more Orthologs mouse all
ARSJ, Official Symbol ARSJprovided by HGNC Official Full Name arylsulfatase family member Jprovided by HGNC Primary source HGNC:HGNC:26286 See related Ensembl:ENSG00000180801 MIM:610010; AllianceGenome:HGNC:26286 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASJ Summary Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008] Expression Broad expression in gall bladder (RPKM 2.3), prostate (RPKM 2.1) and 20 other tissues See more Orthologs mouse all
ARSK, Official Symbol ARSKprovided by HGNC Official Full Name arylsulfatase family member Kprovided by HGNC Primary source HGNC:HGNC:25239 See related Ensembl:ENSG00000164291 MIM:610011; AllianceGenome:HGNC:25239 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MPS10; TSULF Summary Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in thyroid (RPKM 2.9), ovary (RPKM 2.9) and 25 other tissues See more Orthologs mouse all
ARSL, Official Symbol ARSLprovided by HGNC Official Full Name arylsulfatase Lprovided by HGNC Primary source HGNC:HGNC:719 See related Ensembl:ENSG00000157399 MIM:300180; AllianceGenome:HGNC:719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASE; ARSE; CDPX; CDPX1; CDPXR Summary Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013] Expression Biased expression in kidney (RPKM 13.0), liver (RPKM 12.3) and 9 other tissues See more Orthologs all
ARSLP1, Official Symbol ARSLP1provided by HGNC Official Full Name arylsulfatase L pseudogene 1provided by HGNC Primary source HGNC:HGNC:720 See related AllianceGenome:HGNC:720 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARSEP; ARSEP1
ART1, Official Symbol ART1provided by HGNC Official Full Name ADP-ribosyltransferase 1provided by HGNC Primary source HGNC:HGNC:723 See related Ensembl:ENSG00000129744 MIM:601625; AllianceGenome:HGNC:723 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RT6; ART2; ARTC1; CD296 Summary ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
ART2BP, Official Symbol ART2BPprovided by HGNC Official Full Name ADP-ribosyltransferase 2B, pseudogeneprovided by HGNC Primary source HGNC:HGNC:51489 See related Ensembl:ENSG00000237408 AllianceGenome:HGNC:51489 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTC2BP
ART2P, Official Symbol ART2Pprovided by HGNC Official Full Name ADP-ribosyltransferase 2, pseudogeneprovided by HGNC Primary source HGNC:HGNC:724 See related AllianceGenome:HGNC:724 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RT6; ART1P; ARTC2AP
ART3, Official Symbol ART3provided by HGNC Official Full Name ADP-ribosyltransferase 3 (inactive)provided by HGNC Primary source HGNC:HGNC:725 See related Ensembl:ENSG00000156219 MIM:603086; AllianceGenome:HGNC:725 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTC3 Summary This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Biased expression in testis (RPKM 18.7) and heart (RPKM 6.2) See more Orthologs mouse all
ART4, Official Symbol ART4provided by HGNC Official Full Name ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)provided by HGNC Primary source HGNC:HGNC:726 See related Ensembl:ENSG00000111339 MIM:110600; AllianceGenome:HGNC:726 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DO; DOK1; ARTC4; CD297; DO/ART4 Summary This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 8.6), spleen (RPKM 7.9) and 11 other tissues See more Orthologs mouse all
ART5, Official Symbol ART5provided by HGNC Official Full Name ADP-ribosyltransferase 5provided by HGNC Primary source HGNC:HGNC:24049 See related Ensembl:ENSG00000167311 MIM:610625; AllianceGenome:HGNC:24049 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTC5 Summary The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] Expression Biased expression in testis (RPKM 6.5), ovary (RPKM 2.3) and 5 other tissues See more Orthologs mouse all
ARTN, Official Symbol ARTNprovided by HGNC Official Full Name arteminprovided by HGNC Primary source HGNC:HGNC:727 See related Ensembl:ENSG00000117407 MIM:603886; AllianceGenome:HGNC:727 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ART; EVN; NBN; ENOVIN Summary This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016] Expression Broad expression in placenta (RPKM 1.0), prostate (RPKM 0.9) and 20 other tissues See more Orthologs mouse all