psui3905/ncbi_genes_summary huggingface dataset:
LPAR1, Official Symbol LPAR1provided by HGNC Official Full Name lysophosphatidic acid receptor 1provided by HGNC Primary source HGNC:HGNC:3166 See related Ensembl:ENSG00000198121 MIM:602282; AllianceGenome:HGNC:3166 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDG2; LPA1; VZG1; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3 Summary The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020] Expression Ubiquitous expression in brain (RPKM 14.7), placenta (RPKM 8.1) and 22 other tissues See more Orthologs mouse all
LPAR2, Official Symbol LPAR2provided by HGNC Official Full Name lysophosphatidic acid receptor 2provided by HGNC Primary source HGNC:HGNC:3168 See related Ensembl:ENSG00000064547 MIM:605110; AllianceGenome:HGNC:3168 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDG4; LPA2; EDG-4; LPA-2 Summary This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 11.9), bone marrow (RPKM 11.1) and 22 other tissues See more Orthologs mouse all
LPAR3, Official Symbol LPAR3provided by HGNC Official Full Name lysophosphatidic acid receptor 3provided by HGNC Primary source HGNC:HGNC:14298 See related Ensembl:ENSG00000171517 MIM:605106; AllianceGenome:HGNC:14298 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3 Summary This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 8.7), testis (RPKM 8.1) and 12 other tissues See more Orthologs mouse all
LPAR4, Official Symbol LPAR4provided by HGNC Official Full Name lysophosphatidic acid receptor 4provided by HGNC Primary source HGNC:HGNC:4478 See related Ensembl:ENSG00000147145 MIM:300086; AllianceGenome:HGNC:4478 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPA4; P2Y9; GPR23; P2RY9; P2Y5-LIKE Summary This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all
LPAR5, Official Symbol LPAR5provided by HGNC Official Full Name lysophosphatidic acid receptor 5provided by HGNC Primary source HGNC:HGNC:13307 See related Ensembl:ENSG00000184574 MIM:606926; AllianceGenome:HGNC:13307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPA5; GPR92; GPR93; KPG_010 Summary This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008] Expression Broad expression in colon (RPKM 5.6), lymph node (RPKM 4.4) and 23 other tissues See more Orthologs mouse all
LPAR6, Official Symbol LPAR6provided by HGNC Official Full Name lysophosphatidic acid receptor 6provided by HGNC Primary source HGNC:HGNC:15520 See related Ensembl:ENSG00000139679 MIM:609239; AllianceGenome:HGNC:15520 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5 Summary The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] Expression Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues See more Orthologs mouse all
LPCAT1, Official Symbol LPCAT1provided by HGNC Official Full Name lysophosphatidylcholine acyltransferase 1provided by HGNC Primary source HGNC:HGNC:25718 See related Ensembl:ENSG00000153395 MIM:610472; AllianceGenome:HGNC:25718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AYTL2; lpcat; AGPAT9; LPLAT8; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT Summary This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016] Expression Broad expression in lung (RPKM 73.0), spleen (RPKM 32.6) and 18 other tissues See more Orthologs mouse all
LPCAT2, Official Symbol LPCAT2provided by HGNC Official Full Name lysophosphatidylcholine acyltransferase 2provided by HGNC Primary source HGNC:HGNC:26032 See related Ensembl:ENSG00000087253 MIM:612040; AllianceGenome:HGNC:26032 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AYTL1; LPLAT9; AGPAT11; LysoPAFAT Summary This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009] Expression Broad expression in thyroid (RPKM 50.3), bone marrow (RPKM 11.0) and 19 other tissues See more Orthologs mouse all
LPCAT2BP, Official Symbol LPCAT2BPprovided by HGNC Official Full Name lysophosphatidylcholine acyltransferase 2b, pseudogeneprovided by HGNC Primary source HGNC:HGNC:38003 See related Ensembl:ENSG00000233228 AllianceGenome:HGNC:38003 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LPCAT3, Official Symbol LPCAT3provided by HGNC Official Full Name lysophosphatidylcholine acyltransferase 3provided by HGNC Primary source HGNC:HGNC:30244 See related Ensembl:ENSG00000111684 MIM:611950; AllianceGenome:HGNC:30244 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3F; LPCAT; LPSAT; OACT5; nessy; MBOAT5; LPLAT 5; LPLAT12 Summary Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 59.9), small intestine (RPKM 50.5) and 25 other tissues See more Orthologs mouse all
LPCAT4, Official Symbol LPCAT4provided by HGNC Official Full Name lysophosphatidylcholine acyltransferase 4provided by HGNC Primary source HGNC:HGNC:30059 See related Ensembl:ENSG00000176454 MIM:612039; AllianceGenome:HGNC:30059 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AYTL3; AGPAT7; LPEAT2; LPLAT10; LPAAT-eta Summary Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008] Expression Ubiquitous expression in stomach (RPKM 27.5), duodenum (RPKM 20.5) and 23 other tissues See more Orthologs mouse all
LPGAT1, Official Symbol LPGAT1provided by HGNC Official Full Name lysophosphatidylglycerol acyltransferase 1provided by HGNC Primary source HGNC:HGNC:28985 See related Ensembl:ENSG00000123684 MIM:610473; AllianceGenome:HGNC:28985 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NET8; FAM34A; LPLAT7; FAM34A1 Summary This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in small intestine (RPKM 15.0), thyroid (RPKM 14.6) and 25 other tissues See more Orthologs mouse all
LPGAT1-AS1, Official Symbol LPGAT1-AS1provided by HGNC Official Full Name LPGAT1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41221 See related Ensembl:ENSG00000229258 AllianceGenome:HGNC:41221 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.0) See more
LPIN1, Official Symbol LPIN1provided by HGNC Official Full Name lipin 1provided by HGNC Primary source HGNC:HGNC:13345 See related Ensembl:ENSG00000134324 MIM:605518; AllianceGenome:HGNC:13345 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAP1 Summary This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017] Expression Broad expression in testis (RPKM 18.7), ovary (RPKM 8.2) and 24 other tissues See more Orthologs mouse all
LPIN2, Official Symbol LPIN2provided by HGNC Official Full Name lipin 2provided by HGNC Primary source HGNC:HGNC:14450 See related Ensembl:ENSG00000101577 MIM:605519; AllianceGenome:HGNC:14450 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MJDS; CRMO1 Summary Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 28.7), duodenum (RPKM 22.4) and 25 other tissues See more Orthologs mouse all
LPIN3, Official Symbol LPIN3provided by HGNC Official Full Name lipin 3provided by HGNC Primary source HGNC:HGNC:14451 See related Ensembl:ENSG00000132793 MIM:605520; AllianceGenome:HGNC:14451 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMP2; LIPN3L; dJ620E11.2 Summary The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] Expression Ubiquitous expression in duodenum (RPKM 19.3), skin (RPKM 16.1) and 23 other tissues See more Orthologs mouse all
LPL, Official Symbol LPLprovided by HGNC Official Full Name lipoprotein lipaseprovided by HGNC Primary source HGNC:HGNC:6677 See related Ensembl:ENSG00000175445 MIM:609708; AllianceGenome:HGNC:6677 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIPD; HDLCQ11 Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 753.5) and heart (RPKM 154.2) See more Orthologs mouse all
LPO, Official Symbol LPOprovided by HGNC Official Full Name lactoperoxidaseprovided by HGNC Primary source HGNC:HGNC:6678 See related Ensembl:ENSG00000167419 MIM:150205; AllianceGenome:HGNC:6678 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPO Summary This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Restricted expression toward salivary gland (RPKM 211.8) See more Orthologs mouse all
LPP, Official Symbol LPPprovided by HGNC Official Full Name LIM domain containing preferred translocation partner in lipomaprovided by HGNC Primary source HGNC:HGNC:6679 See related Ensembl:ENSG00000145012 MIM:600700; AllianceGenome:HGNC:6679 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in endometrium (RPKM 14.7), esophagus (RPKM 14.3) and 24 other tissues See more Orthologs mouse all
LPP-AS1, Official Symbol LPP-AS1provided by HGNC Official Full Name LPP antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40346 See related Ensembl:ENSG00000224563 AllianceGenome:HGNC:40346 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
LPP-AS2, Official Symbol LPP-AS2provided by HGNC Official Full Name LPP antisense RNA 2provided by HGNC Primary source HGNC:HGNC:27952 See related Ensembl:ENSG00000270959 AllianceGenome:HGNC:27952 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYCLo-5; MYCLo-6
LPXN, Official Symbol LPXNprovided by HGNC Official Full Name leupaxinprovided by HGNC Primary source HGNC:HGNC:14061 See related Ensembl:ENSG00000110031 MIM:605390; AllianceGenome:HGNC:14061 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LDPL Summary The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009] Expression Broad expression in lymph node (RPKM 15.3), appendix (RPKM 9.9) and 22 other tissues See more Orthologs mouse all
LRAT, Official Symbol LRATprovided by HGNC Official Full Name lecithin retinol acyltransferaseprovided by HGNC Primary source HGNC:HGNC:6685 See related Ensembl:ENSG00000121207 MIM:604863; AllianceGenome:HGNC:6685 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCA14 Summary The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] Expression Biased expression in duodenum (RPKM 4.0), small intestine (RPKM 3.3) and 6 other tissues See more Orthologs mouse all
LRATD1, Official Symbol LRATD1provided by HGNC Official Full Name LRAT domain containing 1provided by HGNC Primary source HGNC:HGNC:20743 See related Ensembl:ENSG00000162981 MIM:611234; AllianceGenome:HGNC:20743 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSE1; FAM84A; PP11517 Summary Involved in cell morphogenesis and cell motility. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in colon (RPKM 29.3), small intestine (RPKM 11.3) and 16 other tissues See more Orthologs mouse all
LRATD2, Official Symbol LRATD2provided by HGNC Official Full Name LRAT domain containing 2provided by HGNC Primary source HGNC:HGNC:24166 See related Ensembl:ENSG00000168672 MIM:609483; AllianceGenome:HGNC:24166 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSE2; FAM84B; BCMP101 Summary Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 18.2), salivary gland (RPKM 11.2) and 25 other tissues See more Orthologs mouse all
LRBA, Official Symbol LRBAprovided by HGNC Official Full Name LPS responsive beige-like anchor proteinprovided by HGNC Primary source HGNC:HGNC:1742 See related Ensembl:ENSG00000198589 MIM:606453; AllianceGenome:HGNC:1742 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BGL; LBA; CDC4L; CVID8; LAB300; uc.147 Summary The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in kidney (RPKM 10.0), thyroid (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
LRCH1, Official Symbol LRCH1provided by HGNC Official Full Name leucine rich repeats and calponin homology domain containing 1provided by HGNC Primary source HGNC:HGNC:20309 See related Ensembl:ENSG00000136141 MIM:610368; AllianceGenome:HGNC:20309 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NP81; CHDC1 Summary This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in endometrium (RPKM 5.5), placenta (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
LRCH2, Official Symbol LRCH2provided by HGNC Official Full Name leucine rich repeats and calponin homology domain containing 2provided by HGNC Primary source HGNC:HGNC:29292 See related Ensembl:ENSG00000130224 AllianceGenome:HGNC:29292 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dA204F4.4 Summary This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011] Expression Broad expression in prostate (RPKM 3.7), brain (RPKM 2.9) and 20 other tissues See more Orthologs mouse all
LRCH3, Official Symbol LRCH3provided by HGNC Official Full Name leucine rich repeats and calponin homology domain containing 3provided by HGNC Primary source HGNC:HGNC:28637 See related Ensembl:ENSG00000186001 AllianceGenome:HGNC:28637 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in septin cytoskeleton organization. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 3.8), lymph node (RPKM 3.6) and 25 other tissues See more Orthologs mouse all
LRCH4, Official Symbol LRCH4provided by HGNC Official Full Name leucine rich repeats and calponin homology domain containing 4provided by HGNC Primary source HGNC:HGNC:6691 See related Ensembl:ENSG00000077454 MIM:620165; AllianceGenome:HGNC:6691 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRN; LRRN1; LRRN4; PP14183 Summary This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 33.5), spleen (RPKM 31.2) and 25 other tissues See more Orthologs mouse all
LRCOL1, Official Symbol LRCOL1provided by HGNC Official Full Name leucine rich colipase like 1provided by HGNC Primary source HGNC:HGNC:44160 See related Ensembl:ENSG00000204583 AllianceGenome:HGNC:44160 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable enzyme activator activity. Predicted to be involved in response to food. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 1.8), lung (RPKM 0.7) and 10 other tissues See more Orthologs mouse all
LRFN1, Official Symbol LRFN1provided by HGNC Official Full Name leucine rich repeat and fibronectin type III domain containing 1provided by HGNC Primary source HGNC:HGNC:29290 See related Ensembl:ENSG00000128011 MIM:612807; AllianceGenome:HGNC:29290 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SALM2 Summary Predicted to be involved in regulation of postsynaptic density assembly. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 2.1), spleen (RPKM 1.1) and 18 other tissues See more Orthologs mouse all
LRFN2, Official Symbol LRFN2provided by HGNC Official Full Name leucine rich repeat and fibronectin type III domain containing 2provided by HGNC Primary source HGNC:HGNC:21226 See related Ensembl:ENSG00000156564 MIM:612808; AllianceGenome:HGNC:21226 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SALM1; FIGLER2; KIAA1246 Summary Predicted to be involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse and cell surface. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
LRFN3, Official Symbol LRFN3provided by HGNC Official Full Name leucine rich repeat and fibronectin type III domain containing 3provided by HGNC Primary source HGNC:HGNC:28370 See related Ensembl:ENSG00000126243 MIM:612809; AllianceGenome:HGNC:28370 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SALM4; FIGLER1 Summary Predicted to be involved in regulation of presynapse assembly; regulation of synaptic membrane adhesion; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in cell surface and glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 3.2), fat (RPKM 3.1) and 24 other tissues See more Orthologs mouse all
LRFN4, Official Symbol LRFN4provided by HGNC Official Full Name leucine rich repeat and fibronectin type III domain containing 4provided by HGNC Primary source HGNC:HGNC:28456 See related Ensembl:ENSG00000173621 MIM:612810; AllianceGenome:HGNC:28456 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SALM3; SALM3.; FIGLER6 Summary Predicted to be involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in GABA-ergic synapse; cell surface; and glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 5.8), colon (RPKM 4.2) and 22 other tissues See more Orthologs mouse all
LRFN5, Official Symbol LRFN5provided by HGNC Official Full Name leucine rich repeat and fibronectin type III domain containing 5provided by HGNC Primary source HGNC:HGNC:20360 See related Ensembl:ENSG00000165379 MIM:612811; AllianceGenome:HGNC:20360 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SALM5; FIGLER8; C14orf146 Summary This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016] Expression Biased expression in brain (RPKM 2.4), adrenal (RPKM 0.8) and 13 other tissues See more Orthologs mouse all
LRG1, Official Symbol LRG1provided by HGNC Official Full Name leucine rich alpha-2-glycoprotein 1provided by HGNC Primary source HGNC:HGNC:29480 See related Ensembl:ENSG00000171236 MIM:611289; AllianceGenome:HGNC:29480 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRG; HMFT1766 Summary The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008] Expression Biased expression in liver (RPKM 150.7), esophagus (RPKM 16.6) and 4 other tissues See more Orthologs mouse all
LRGUK, Official Symbol LRGUKprovided by HGNC Official Full Name leucine rich repeats and guanylate kinase domain containingprovided by HGNC Primary source HGNC:HGNC:21964 See related Ensembl:ENSG00000155530 MIM:616478; AllianceGenome:HGNC:21964 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CFAP246 Summary Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 1.3), lung (RPKM 0.2) and 7 other tissues See more Orthologs mouse all
LRIF1, Official Symbol LRIF1provided by HGNC Official Full Name ligand dependent nuclear receptor interacting factor 1provided by HGNC Primary source HGNC:HGNC:30299 See related Ensembl:ENSG00000121931 MIM:615354; AllianceGenome:HGNC:30299 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIF1; FSHD3; HBiX1; C1orf103 Summary Predicted to enable retinoic acid receptor binding activity. Involved in dosage compensation by inactivation of X chromosome. Located in Barr body; centriolar satellite; and nucleoplasm. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 11.6), ovary (RPKM 5.5) and 24 other tissues See more Orthologs mouse all
LRIG1, Official Symbol LRIG1provided by HGNC Official Full Name leucine rich repeats and immunoglobulin like domains 1provided by HGNC Primary source HGNC:HGNC:17360 See related Ensembl:ENSG00000144749 MIM:608868; AllianceGenome:HGNC:17360 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIG1; LIG-1 Summary Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 61.1), fat (RPKM 28.0) and 23 other tissues See more Orthologs mouse all
LRIG2, Official Symbol LRIG2provided by HGNC Official Full Name leucine rich repeats and immunoglobulin like domains 2provided by HGNC Primary source HGNC:HGNC:20889 See related Ensembl:ENSG00000198799 MIM:608869; AllianceGenome:HGNC:20889 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIG2; UFS2; LIG-2 Summary This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] Expression Ubiquitous expression in thyroid (RPKM 2.7), ovary (RPKM 2.5) and 25 other tissues See more Orthologs mouse all
LRIG2-DT, Official Symbol LRIG2-DTprovided by HGNC Official Full Name LRIG2 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:54312 See related Ensembl:ENSG00000238198 AllianceGenome:HGNC:54312 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
LRIG3, Official Symbol LRIG3provided by HGNC Official Full Name leucine rich repeats and immunoglobulin like domains 3provided by HGNC Primary source HGNC:HGNC:30991 See related Ensembl:ENSG00000139263 MIM:608870; AllianceGenome:HGNC:30991 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIG3 Summary Predicted to act upstream of or within otolith morphogenesis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in thyroid (RPKM 16.5), skin (RPKM 7.2) and 24 other tissues See more Orthologs mouse all
LRIT1, Official Symbol LRIT1provided by HGNC Official Full Name leucine rich repeat, Ig-like and transmembrane domains 1provided by HGNC Primary source HGNC:HGNC:23404 See related Ensembl:ENSG00000148602 MIM:616103; AllianceGenome:HGNC:23404 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAL; LRRC21; FIGLER9 Summary Predicted to be integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 2.4) See more Orthologs mouse all
LRIT2, Official Symbol LRIT2provided by HGNC Official Full Name leucine rich repeat, Ig-like and transmembrane domains 2provided by HGNC Primary source HGNC:HGNC:23443 See related Ensembl:ENSG00000204033 AllianceGenome:HGNC:23443 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC22 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 1.2), brain (RPKM 0.4) and 1 other tissue See more Orthologs mouse all
LRIT3, Official Symbol LRIT3provided by HGNC Official Full Name leucine rich repeat, Ig-like and transmembrane domains 3provided by HGNC Primary source HGNC:HGNC:24783 See related Ensembl:ENSG00000183423 MIM:615004; AllianceGenome:HGNC:24783 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSNB1F; FIGLER4 Summary This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. [provided by RefSeq, May 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all
LRMDA, Official Symbol LRMDAprovided by HGNC Official Full Name leucine rich melanocyte differentiation associatedprovided by HGNC Primary source HGNC:HGNC:23405 See related Ensembl:ENSG00000148655 MIM:614537; AllianceGenome:HGNC:23405 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDA017; C10orf11 Summary This gene encodes a leucine-rich repeat protein. The encoded protein is thought to play a role in melanocyte differentiation. Mutations in this gene have been associated with autosomal recessive oculocutaneous albinism 7 (OCA7). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015] Expression Ubiquitous expression in adrenal (RPKM 1.6), spleen (RPKM 0.7) and 24 other tissues See more Orthologs mouse all
LRP1, Official Symbol LRP1provided by HGNC Official Full Name LDL receptor related protein 1provided by HGNC Primary source HGNC:HGNC:6692 See related Ensembl:ENSG00000123384 MIM:107770; AllianceGenome:HGNC:6692 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1 Summary This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in fat (RPKM 73.6), ovary (RPKM 50.9) and 22 other tissues See more Orthologs mouse all
LRP1-AS, Official Symbol LRP1-ASprovided by HGNC Official Full Name LRP1 antisense RNAprovided by HGNC Primary source HGNC:HGNC:51694 See related Ensembl:ENSG00000259125 AllianceGenome:HGNC:51694 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in ovary (RPKM 3.9), placenta (RPKM 2.7) and 22 other tissues See more
LRP10, Official Symbol LRP10provided by HGNC Official Full Name LDL receptor related protein 10provided by HGNC Primary source HGNC:HGNC:14553 See related Ensembl:ENSG00000197324 MIM:609921; AllianceGenome:HGNC:14553 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRP9; LRP-10; MST087; MSTP087 Summary This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in esophagus (RPKM 34.1), colon (RPKM 29.6) and 25 other tissues See more Orthologs mouse all
LRP11, Official Symbol LRP11provided by HGNC Official Full Name LDL receptor related protein 11provided by HGNC Primary source HGNC:HGNC:16936 See related Ensembl:ENSG00000120256 AllianceGenome:HGNC:16936 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MANSC3; bA350J20.3 Summary Enables phosphoprotein binding activity. Predicted to act upstream of or within several processes, including response to cold; response to immobilization stress; and response to water deprivation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 11.0), brain (RPKM 10.7) and 24 other tissues See more Orthologs mouse all