psui3905/ncbi_genes_summary huggingface dataset:
TRIP4, Official Symbol TRIP4provided by HGNC Official Full Name thyroid hormone receptor interactor 4provided by HGNC Primary source HGNC:HGNC:12310 See related Ensembl:ENSG00000103671 MIM:604501; AllianceGenome:HGNC:12310 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASC1; ASC-1; MDCDC; SMABF1; ZC2HC5; HsT17391 Summary This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in thyroid (RPKM 15.4), kidney (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
TRIP6, Official Symbol TRIP6provided by HGNC Official Full Name thyroid hormone receptor interactor 6provided by HGNC Primary source HGNC:HGNC:12311 See related Ensembl:ENSG00000087077 MIM:602933; AllianceGenome:HGNC:12311 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2 Summary This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 26.6), kidney (RPKM 24.0) and 25 other tissues See more Orthologs mouse all
TRIQK, Official Symbol TRIQKprovided by HGNC Official Full Name triple QxxK/R motif containingprovided by HGNC Primary source HGNC:HGNC:27828 See related Ensembl:ENSG00000205133 AllianceGenome:HGNC:27828 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C8orf83; PRO0845; UPF0599 Summary Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 10.3), thyroid (RPKM 9.6) and 25 other tissues See more Orthologs mouse all
TRIR, Official Symbol TRIRprovided by HGNC Official Full Name telomerase RNA component interacting RNaseprovided by HGNC Primary source HGNC:HGNC:28424 See related Ensembl:ENSG00000123144 AllianceGenome:HGNC:28424 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TERCIR; fSAP18; C19orf43 Summary Enables 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 63.1), colon (RPKM 57.1) and 25 other tissues See more Orthologs mouse all
TRIT1, Official Symbol TRIT1provided by HGNC Official Full Name tRNA isopentenyltransferase 1provided by HGNC Primary source HGNC:HGNC:20286 See related Ensembl:ENSG00000043514 MIM:617840; AllianceGenome:HGNC:20286 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPT; GRO1; IPPT; MOD5; hGRO1; IPTase; COXPD35 Summary This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015] Expression Ubiquitous expression in thyroid (RPKM 7.3), prostate (RPKM 6.7) and 25 other tissues See more Orthologs mouse all
TRMO, Official Symbol TRMOprovided by HGNC Official Full Name tRNA methyltransferase Oprovided by HGNC Primary source HGNC:HGNC:30967 See related Ensembl:ENSG00000136932 AllianceGenome:HGNC:30967 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAP1; HSPC219; C9orf156 Summary Enables tRNA (adenine-N6-)-methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 2.2), lymph node (RPKM 1.5) and 25 other tissues See more Orthologs mouse all
TRMT1, Official Symbol TRMT1provided by HGNC Official Full Name tRNA methyltransferase 1provided by HGNC Primary source HGNC:HGNC:25980 See related Ensembl:ENSG00000104907 MIM:611669; AllianceGenome:HGNC:25980 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM1; MRT68 Summary This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017] Expression Ubiquitous expression in spleen (RPKM 12.4), lymph node (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
TRMT10A, Official Symbol TRMT10Aprovided by HGNC Official Full Name tRNA methyltransferase 10Aprovided by HGNC Primary source HGNC:HGNC:28403 See related Ensembl:ENSG00000145331 MIM:616013; AllianceGenome:HGNC:28403 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSSGM; TRM10; MSSGM1; RG9MTD2; HEL-S-88 Summary This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] Expression Ubiquitous expression in testis (RPKM 4.1), thyroid (RPKM 2.7) and 25 other tissues See more Orthologs mouse all
TRMT10B, Official Symbol TRMT10Bprovided by HGNC Official Full Name tRNA methyltransferase 10Bprovided by HGNC Primary source HGNC:HGNC:26454 See related Ensembl:ENSG00000165275 AllianceGenome:HGNC:26454 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RG9MTD3; bA3J10.9 Summary Enables tRNA (guanine-N1-)-methyltransferase activity. Predicted to be involved in mitochondrial tRNA processing. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 2.9), brain (RPKM 2.7) and 25 other tissues See more Orthologs mouse all
TRMT10C, Official Symbol TRMT10Cprovided by HGNC Official Full Name tRNA methyltransferase 10C, mitochondrial RNase P subunitprovided by HGNC Primary source HGNC:HGNC:26022 See related Ensembl:ENSG00000174173 MIM:615423; AllianceGenome:HGNC:26022 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNYA; MRPP1; COXPD30; RG9MTD1 Summary This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012] Expression Ubiquitous expression in adrenal (RPKM 10.2), lymph node (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
TRMT11, Official Symbol TRMT11provided by HGNC Official Full Name tRNA methyltransferase 11 homologprovided by HGNC Primary source HGNC:HGNC:21080 See related Ensembl:ENSG00000066651 AllianceGenome:HGNC:21080 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM11; MDS024; C6orf75; TRMT11-1 Summary Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 2.2), duodenum (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
TRMT112, Official Symbol TRMT112provided by HGNC Official Full Name tRNA methyltransferase activator subunit 11-2provided by HGNC Primary source HGNC:HGNC:26940 See related Ensembl:ENSG00000173113 MIM:618630; AllianceGenome:HGNC:26940 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2 Summary Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues See more Orthologs mouse all
TRMT112P2, Official Symbol TRMT112P2provided by HGNC Official Full Name tRNA methyltransferase subunit 11-2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:44021 See related Ensembl:ENSG00000249778 AllianceGenome:HGNC:44021 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TRMT112P5, Official Symbol TRMT112P5provided by HGNC Official Full Name tRNA methyltransferase subunit 11-2 pseudogene 5provided by HGNC Primary source HGNC:HGNC:44024 See related Ensembl:ENSG00000250161 AllianceGenome:HGNC:44024 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TRMT12, Official Symbol TRMT12provided by HGNC Official Full Name tRNA methyltransferase 12 homologprovided by HGNC Primary source HGNC:HGNC:26091 See related Ensembl:ENSG00000183665 MIM:611244; AllianceGenome:HGNC:26091 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TYW2; TRM12 Summary Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008] Orthologs mouse all
TRMT13, Official Symbol TRMT13provided by HGNC Official Full Name tRNA methyltransferase 13 homologprovided by HGNC Primary source HGNC:HGNC:25502 See related Ensembl:ENSG00000122435 AllianceGenome:HGNC:25502 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCDC76 Summary Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 6.2), appendix (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
TRMT1L, Official Symbol TRMT1Lprovided by HGNC Official Full Name tRNA methyltransferase 1 likeprovided by HGNC Primary source HGNC:HGNC:16782 See related Ensembl:ENSG00000121486 MIM:611673; AllianceGenome:HGNC:16782 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM1L; MST070; C1orf25; MSTP070; bG120K12.3 Summary This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011] Expression Broad expression in testis (RPKM 9.7), kidney (RPKM 3.9) and 24 other tissues See more Orthologs mouse all
TRMT1P1, Official Symbol TRMT1P1provided by HGNC Official Full Name TRMT1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:55145 See related Ensembl:ENSG00000231093 AllianceGenome:HGNC:55145 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TRMT2A, Official Symbol TRMT2Aprovided by HGNC Official Full Name tRNA methyltransferase 2 homolog Aprovided by HGNC Primary source HGNC:HGNC:24974 See related Ensembl:ENSG00000099899 MIM:611151; AllianceGenome:HGNC:24974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTF9C Summary The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in spleen (RPKM 11.1), testis (RPKM 10.2) and 25 other tissues See more Orthologs mouse all
TRMT2B, Official Symbol TRMT2Bprovided by HGNC Official Full Name tRNA methyltransferase 2 homolog Bprovided by HGNC Primary source HGNC:HGNC:25748 See related Ensembl:ENSG00000188917 AllianceGenome:HGNC:25748 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXorf34; dJ341D10.3 Summary This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009] Expression Ubiquitous expression in thyroid (RPKM 3.4), spleen (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
TRMT2B-AS1, Official Symbol TRMT2B-AS1provided by HGNC Official Full Name TRMT2B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41116 See related AllianceGenome:HGNC:41116 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
TRMT44, Official Symbol TRMT44provided by HGNC Official Full Name tRNA methyltransferase 44 homologprovided by HGNC Primary source HGNC:HGNC:26653 See related Ensembl:ENSG00000155275 MIM:614309; AllianceGenome:HGNC:26653 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM44; C4orf23; METTL19 Summary The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. [provided by RefSeq, May 2012] Expression Ubiquitous expression in ovary (RPKM 2.0), testis (RPKM 1.4) and 25 other tissues See more Orthologs mouse all
TRMT5, Official Symbol TRMT5provided by HGNC Official Full Name tRNA methyltransferase 5provided by HGNC Primary source HGNC:HGNC:23141 See related Ensembl:ENSG00000126814 MIM:611023; AllianceGenome:HGNC:23141 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM5; PNSED; COXPD26; KIAA1393 Summary tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 5.1), ovary (RPKM 4.1) and 25 other tissues See more Orthologs mouse all
TRMT6, Official Symbol TRMT6provided by HGNC Official Full Name tRNA methyltransferase 6 non-catalytic subunitprovided by HGNC Primary source HGNC:HGNC:20900 See related Ensembl:ENSG00000089195 AllianceGenome:HGNC:20900 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCD10; CGI-09; Gcd10p Summary This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in testis (RPKM 9.9), bone marrow (RPKM 9.2) and 25 other tissues See more Orthologs mouse all
TRMT61A, Official Symbol TRMT61Aprovided by HGNC Official Full Name tRNA methyltransferase 61Aprovided by HGNC Primary source HGNC:HGNC:23790 See related Ensembl:ENSG00000166166 AllianceGenome:HGNC:23790 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCD14; TRM61; Gcd14p; hTRM61; C14orf172 Summary Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 4.4), prostate (RPKM 4.3) and 25 other tissues See more Orthologs mouse all
TRMT61B, Official Symbol TRMT61Bprovided by HGNC Official Full Name tRNA methyltransferase 61Bprovided by HGNC Primary source HGNC:HGNC:26070 See related Ensembl:ENSG00000171103 MIM:619404; AllianceGenome:HGNC:26070 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation; mitochondrial tRNA methylation; and protein homooligomerization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 8.4), small intestine (RPKM 6.4) and 25 other tissues See more Orthologs all
TRMT9B, Official Symbol TRMT9Bprovided by HGNC Official Full Name tRNA methyltransferase 9B (putative)provided by HGNC Primary source HGNC:HGNC:26725 See related Ensembl:ENSG00000250305 MIM:615666; AllianceGenome:HGNC:26725 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM9L; hTRM9L; C8orf79; KIAA1456 Summary Enables tRNA methyltransferase activity. Predicted to be involved in tRNA wobble uridine modification. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 9.8), brain (RPKM 1.5) and 7 other tissues See more Orthologs mouse all
TRMU, Official Symbol TRMUprovided by HGNC Official Full Name tRNA mitochondrial 2-thiouridylaseprovided by HGNC Primary source HGNC:HGNC:25481 See related Ensembl:ENSG00000100416 MIM:610230; AllianceGenome:HGNC:25481 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTO2; MTU1; TRMT; LCAL3; TRMT1 Summary This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in spleen (RPKM 4.2), skin (RPKM 3.8) and 25 other tissues See more Orthologs mouse all
TRNAU1AP, Official Symbol TRNAU1APprovided by HGNC Official Full Name tRNA selenocysteine 1 associated protein 1provided by HGNC Primary source HGNC:HGNC:30813 See related Ensembl:ENSG00000180098 MIM:619597; AllianceGenome:HGNC:30813 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SECP43; PRO1902; TRSPAP1 Summary Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 5.3), urinary bladder (RPKM 4.9) and 25 other tissues See more Orthologs mouse all
TRNP1, Official Symbol TRNP1provided by HGNC Official Full Name TMF1 regulated nuclear protein 1provided by HGNC Primary source HGNC:HGNC:34348 See related Ensembl:ENSG00000253368 MIM:616824; AllianceGenome:HGNC:34348 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNRP; TRNP; C1orf225 Summary Predicted to enable DNA binding activity. Predicted to be involved in several processes, including cerebellar cortex morphogenesis; neural precursor cell proliferation; and regulation of cell population proliferation. Predicted to be active in nucleus. Predicted to colocalize with euchromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in stomach (RPKM 40.7), esophagus (RPKM 17.0) and 7 other tissues See more Orthologs mouse all
TRNT1, Official Symbol TRNT1provided by HGNC Official Full Name tRNA nucleotidyl transferase 1provided by HGNC Primary source HGNC:HGNC:17341 See related Ensembl:ENSG00000072756 MIM:612907; AllianceGenome:HGNC:17341 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCA1; RPEM; SIFD; MtCCA; CGI-47 Summary The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in prostate (RPKM 8.6), testis (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
TRO, Official Symbol TROprovided by HGNC Official Full Name trophininprovided by HGNC Primary source HGNC:HGNC:12326 See related Ensembl:ENSG00000067445 MIM:300132; AllianceGenome:HGNC:12326 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAGED3; MAGE-d3 Summary This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012] Expression Broad expression in ovary (RPKM 9.7), brain (RPKM 9.7) and 20 other tissues See more Orthologs mouse all
TROAP, Official Symbol TROAPprovided by HGNC Official Full Name trophinin associated proteinprovided by HGNC Primary source HGNC:HGNC:12327 See related Ensembl:ENSG00000135451 MIM:603872; AllianceGenome:HGNC:12327 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TASTIN Summary Predicted to be involved in cell adhesion. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 7.6), bone marrow (RPKM 6.1) and 11 other tissues See more Orthologs mouse all
TRPA1, Official Symbol TRPA1provided by HGNC Official Full Name transient receptor potential cation channel subfamily A member 1provided by HGNC Primary source HGNC:HGNC:497 See related Ensembl:ENSG00000104321 MIM:604775; AllianceGenome:HGNC:497 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FEPS; p120; FEPS1; ANKTM1 Summary The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008] Expression Biased expression in urinary bladder (RPKM 5.8), colon (RPKM 2.2) and 5 other tissues See more Orthologs mouse all
TRPC1, Official Symbol TRPC1provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 1provided by HGNC Primary source HGNC:HGNC:12333 See related Ensembl:ENSG00000144935 MIM:602343; AllianceGenome:HGNC:12333 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP1; HTRP-1 Summary The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.9) and 22 other tissues See more Orthologs mouse all
TRPC2, Official Symbol TRPC2provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 2 (pseudogene)provided by HGNC Primary source HGNC:HGNC:12334 See related Ensembl:ENSG00000290962 AllianceGenome:HGNC:12334 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable several functions, including calmodulin binding activity; diacylglycerol binding activity; and inositol 1,4,5 trisphosphate binding activity. Predicted to act upstream of or within several processes, including inter-male aggressive behavior; mating behavior; and territorial aggressive behavior. Predicted to be located in several cellular components, including Golgi membrane; dendrite membrane; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 1.0), lung (RPKM 0.4) and 11 other tissues See more
TRPC3, Official Symbol TRPC3provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 3provided by HGNC Primary source HGNC:HGNC:12335 See related Ensembl:ENSG00000138741 MIM:602345; AllianceGenome:HGNC:12335 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP3; SCA41 Summary The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
TRPC4, Official Symbol TRPC4provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 4provided by HGNC Primary source HGNC:HGNC:12336 See related Ensembl:ENSG00000133107 MIM:603651; AllianceGenome:HGNC:12336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP4; HTRP4; HTRP-4 Summary This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] Expression Biased expression in endometrium (RPKM 6.2), prostate (RPKM 2.5) and 8 other tissues See more Orthologs mouse all
TRPC4AP, Official Symbol TRPC4APprovided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 4 associated proteinprovided by HGNC Primary source HGNC:HGNC:16181 See related Ensembl:ENSG00000100991 MIM:608430; AllianceGenome:HGNC:16181 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRUSS; TRRP4AP; PPP1R158; C20orf188 Summary Enables phosphatase binding activity and ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 20.6), spleen (RPKM 19.3) and 25 other tissues See more Orthologs mouse all
TRPC5, Official Symbol TRPC5provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 5provided by HGNC Primary source HGNC:HGNC:12337 See related Ensembl:ENSG00000072315 MIM:300334; AllianceGenome:HGNC:12337 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP5; PPP1R159 Summary This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
TRPC5OS, Official Symbol TRPC5OSprovided by HGNC Official Full Name TRPC5 opposite strandprovided by HGNC Primary source HGNC:HGNC:40593 See related Ensembl:ENSG00000204025 AllianceGenome:HGNC:40593 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRPC5-AS1 Expression Restricted expression toward testis (RPKM 13.8) See more Orthologs mouse all
TRPC6, Official Symbol TRPC6provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 6provided by HGNC Primary source HGNC:HGNC:12338 See related Ensembl:ENSG00000137672 MIM:603652; AllianceGenome:HGNC:12338 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP6; FSGS2 Summary The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009] Expression Broad expression in placenta (RPKM 7.7), lung (RPKM 7.3) and 18 other tissues See more Orthologs mouse all
TRPC7, Official Symbol TRPC7provided by HGNC Official Full Name transient receptor potential cation channel subfamily C member 7provided by HGNC Primary source HGNC:HGNC:20754 See related Ensembl:ENSG00000069018 AllianceGenome:HGNC:20754 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRP7 Summary Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within calcium ion transport. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
TRPC7-AS1, Official Symbol TRPC7-AS1provided by HGNC Official Full Name TRPC7 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40936 See related Ensembl:ENSG00000248211 AllianceGenome:HGNC:40936 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TRPC7-AS2, Official Symbol TRPC7-AS2provided by HGNC Official Full Name TRPC7 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40937 See related Ensembl:ENSG00000250947 AllianceGenome:HGNC:40937 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTB-28J9.2 Expression Low expression observed in reference dataset See more
TRPM1, Official Symbol TRPM1provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 1provided by HGNC Primary source HGNC:HGNC:7146 See related Ensembl:ENSG00000134160 MIM:603576; AllianceGenome:HGNC:7146 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLSN1; CSNB1C; LTRPC1 Summary This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] Expression Biased expression in skin (RPKM 2.8) and testis (RPKM 1.1) See more Orthologs mouse all
TRPM2, Official Symbol TRPM2provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 2provided by HGNC Primary source HGNC:HGNC:12339 See related Ensembl:ENSG00000142185 MIM:603749; AllianceGenome:HGNC:12339 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1 Summary The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016] Expression Broad expression in bone marrow (RPKM 4.5), brain (RPKM 2.6) and 21 other tissues See more Orthologs mouse all
TRPM3, Official Symbol TRPM3provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 3provided by HGNC Primary source HGNC:HGNC:17992 See related Ensembl:ENSG00000083067 MIM:608961; AllianceGenome:HGNC:17992 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GON-2; MLSN2; LTRPC3; NEDFSS; CTRCT50 Summary The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 3.0), brain (RPKM 0.8) and 2 other tissues See more Orthologs all
TRPM4, Official Symbol TRPM4provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 4provided by HGNC Primary source HGNC:HGNC:17993 See related Ensembl:ENSG00000130529 MIM:606936; AllianceGenome:HGNC:17993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EKVP6; LTrpC4; PFHB1B; TRPM4B; hTRPM4 Summary The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016] Expression Broad expression in colon (RPKM 24.0), prostate (RPKM 19.3) and 19 other tissues See more Orthologs mouse all
TRPM5, Official Symbol TRPM5provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 5provided by HGNC Primary source HGNC:HGNC:14323 See related Ensembl:ENSG00000070985 MIM:604600; AllianceGenome:HGNC:14323 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTR1; LTRPC5 Summary This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010] Expression Biased expression in duodenum (RPKM 1.1), testis (RPKM 1.1) and 8 other tissues See more Orthologs mouse all
TRPM6, Official Symbol TRPM6provided by HGNC Official Full Name transient receptor potential cation channel subfamily M member 6provided by HGNC Primary source HGNC:HGNC:17995 See related Ensembl:ENSG00000119121 MIM:607009; AllianceGenome:HGNC:17995 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSH; HMGX; HOMG; CHAK2; HOMG1 Summary This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010] Expression Biased expression in colon (RPKM 8.1), small intestine (RPKM 3.5) and 5 other tissues See more Orthologs mouse all