psui3905/ncbi_genes_summary huggingface dataset:
TLR9, Official Symbol TLR9provided by HGNC Official Full Name toll like receptor 9provided by HGNC Primary source HGNC:HGNC:15633 See related Ensembl:ENSG00000239732 MIM:605474; AllianceGenome:HGNC:15633 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD289 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017] Expression Broad expression in lymph node (RPKM 2.9), spleen (RPKM 1.9) and 16 other tissues See more Orthologs mouse all
TLX1, Official Symbol TLX1provided by HGNC Official Full Name T cell leukemia homeobox 1provided by HGNC Primary source HGNC:HGNC:5056 See related Ensembl:ENSG00000107807 MIM:186770; AllianceGenome:HGNC:5056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCL3; HOX11 Summary This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] Expression Biased expression in spleen (RPKM 14.4) and salivary gland (RPKM 3.2) See more Orthologs mouse all
TLX1NB, Official Symbol TLX1NBprovided by HGNC Official Full Name TLX1 neighborprovided by HGNC Primary source HGNC:HGNC:37183 See related Ensembl:ENSG00000236311 MIM:612734; AllianceGenome:HGNC:37183 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TD1; TDI; APT-B7 Expression Low expression observed in reference dataset See more Orthologs all
TLX2, Official Symbol TLX2provided by HGNC Official Full Name T cell leukemia homeobox 2provided by HGNC Primary source HGNC:HGNC:5057 See related Ensembl:ENSG00000115297 MIM:604240; AllianceGenome:HGNC:5057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCX; HOX11L1 Summary This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
TLX3, Official Symbol TLX3provided by HGNC Official Full Name T cell leukemia homeobox 3provided by HGNC Primary source HGNC:HGNC:13532 See related Ensembl:ENSG00000164438 MIM:604640; AllianceGenome:HGNC:13532 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNX; HOX11L2 Summary The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015] Expression Low expression observed in reference dataset See more Orthologs mouse all
TM2D1, Official Symbol TM2D1provided by HGNC Official Full Name TM2 domain containing 1provided by HGNC Primary source HGNC:HGNC:24142 See related Ensembl:ENSG00000162604 MIM:610080; AllianceGenome:HGNC:24142 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BBP Summary The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in thyroid (RPKM 16.4), adrenal (RPKM 15.2) and 25 other tissues See more Orthologs mouse all
TM2D2, Official Symbol TM2D2provided by HGNC Official Full Name TM2 domain containing 2provided by HGNC Primary source HGNC:HGNC:24127 See related Ensembl:ENSG00000169490 MIM:610081; AllianceGenome:HGNC:24127 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLP1 Summary The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 10.1), kidney (RPKM 10.0) and 25 other tissues See more Orthologs mouse all
TM2D3, Official Symbol TM2D3provided by HGNC Official Full Name TM2 domain containing 3provided by HGNC Primary source HGNC:HGNC:24128 See related Ensembl:ENSG00000184277 MIM:610014; AllianceGenome:HGNC:24128 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLP2 Summary The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 24.1), ovary (RPKM 18.7) and 25 other tissues See more Orthologs mouse all
TM4SF1, Official Symbol TM4SF1provided by HGNC Official Full Name transmembrane 4 L six family member 1provided by HGNC Primary source HGNC:HGNC:11853 See related Ensembl:ENSG00000169908 MIM:191155; AllianceGenome:HGNC:11853 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L6; H-L6; M3S1; TAAL6 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 142.0), lung (RPKM 138.0) and 24 other tissues See more Orthologs mouse all
TM4SF1-AS1, Official Symbol TM4SF1-AS1provided by HGNC Official Full Name TM4SF1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40587 See related Ensembl:ENSG00000240541 AllianceGenome:HGNC:40587 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in lung (RPKM 30.8), gall bladder (RPKM 20.1) and 19 other tissues See more
TM4SF18, Official Symbol TM4SF18provided by HGNC Official Full Name transmembrane 4 L six family member 18provided by HGNC Primary source HGNC:HGNC:25181 See related Ensembl:ENSG00000163762 AllianceGenome:HGNC:25181 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L6D Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 15.9), fat (RPKM 12.5) and 21 other tissues See more Orthologs all
TM4SF19, Official Symbol TM4SF19provided by HGNC Official Full Name transmembrane 4 L six family member 19provided by HGNC Primary source HGNC:HGNC:25167 See related Ensembl:ENSG00000145107 AllianceGenome:HGNC:25167 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OCTM4 Summary The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017] Expression Biased expression in testis (RPKM 3.1), esophagus (RPKM 0.9) and 10 other tissues See more Orthologs mouse all
TM4SF19-AS1, Official Symbol TM4SF19-AS1provided by HGNC Official Full Name TM4SF19 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41085 See related Ensembl:ENSG00000235897 AllianceGenome:HGNC:41085 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 2.0), spleen (RPKM 0.3) and 16 other tissues See more
TM4SF19-DYNLT2B, Official Symbol TM4SF19-DYNLT2Bprovided by HGNC Official Full Name TM4SF19-DYNLT2B readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:49190 See related AllianceGenome:HGNC:49190 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TM4SF19-TCTEX1D2 Summary This locus represents naturally occurring read-through transcription between the neighboring transmembrane 4 L six family member 19 (TM4SF19) and Tctex1 domain containing 2 (TCTEX1D2) genes on chromosome 3. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus not expected to produce a protein product. [provided by RefSeq, Mar 2011] Expression Broad expression in testis (RPKM 5.3), esophagus (RPKM 1.5) and 21 other tissues See more
TM4SF20, Official Symbol TM4SF20provided by HGNC Official Full Name transmembrane 4 L six family member 20provided by HGNC Primary source HGNC:HGNC:26230 See related Ensembl:ENSG00000168955 MIM:615404; AllianceGenome:HGNC:26230 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLI5; PRO994; TCCE518 Summary The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016] Expression Biased expression in duodenum (RPKM 117.7) and small intestine (RPKM 65.0) See more Orthologs mouse all
TM4SF4, Official Symbol TM4SF4provided by HGNC Official Full Name transmembrane 4 L six family member 4provided by HGNC Primary source HGNC:HGNC:11856 See related Ensembl:ENSG00000169903 MIM:606567; AllianceGenome:HGNC:11856 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILTMP; il-TMP Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011] Expression Biased expression in gall bladder (RPKM 554.1), duodenum (RPKM 308.9) and 2 other tissues See more Orthologs mouse all
TM4SF5, Official Symbol TM4SF5provided by HGNC Official Full Name transmembrane 4 L six family member 5provided by HGNC Primary source HGNC:HGNC:11857 See related Ensembl:ENSG00000142484 MIM:604657; AllianceGenome:HGNC:11857 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008] Expression Biased expression in duodenum (RPKM 71.1), small intestine (RPKM 65.8) and 4 other tissues See more Orthologs mouse all
TM6SF1, Official Symbol TM6SF1provided by HGNC Official Full Name transmembrane 6 superfamily member 1provided by HGNC Primary source HGNC:HGNC:11860 See related Ensembl:ENSG00000136404 MIM:606562; AllianceGenome:HGNC:11860 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. Predicted to be active in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 3.4), thyroid (RPKM 3.0) and 24 other tissues See more Orthologs mouse all
TM6SF2, Official Symbol TM6SF2provided by HGNC Official Full Name transmembrane 6 superfamily member 2provided by HGNC Primary source HGNC:HGNC:11861 See related Ensembl:ENSG00000213996 MIM:606563; AllianceGenome:HGNC:11861 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables identical protein binding activity. Involved in regulation of lipid metabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 49.9), small intestine (RPKM 45.9) and 1 other tissue See more Orthologs mouse all
TM7SF2, Official Symbol TM7SF2provided by HGNC Official Full Name transmembrane 7 superfamily member 2provided by HGNC Primary source HGNC:HGNC:11863 See related Ensembl:ENSG00000149809 MIM:603414; AllianceGenome:HGNC:11863 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANG1; C14SR; NET47; DHCR14A Summary Enables delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in adrenal (RPKM 80.1), fat (RPKM 50.5) and 20 other tissues See more Orthologs mouse all
TM7SF3, Official Symbol TM7SF3provided by HGNC Official Full Name transmembrane 7 superfamily member 3provided by HGNC Primary source HGNC:HGNC:23049 See related Ensembl:ENSG00000064115 MIM:605181; AllianceGenome:HGNC:23049 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in cellular response to unfolded protein; negative regulation of programmed cell death; and positive regulation of insulin secretion. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 20.0), lung (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
TM9SF1, Official Symbol TM9SF1provided by HGNC Official Full Name transmembrane 9 superfamily member 1provided by HGNC Primary source HGNC:HGNC:11864 See related Ensembl:ENSG00000100926 MIM:618965; AllianceGenome:HGNC:11864 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MP70; HMP70 Summary Predicted to be involved in protein localization to membrane. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 24.3), prostate (RPKM 17.5) and 25 other tissues See more Orthologs mouse all
TM9SF2, Official Symbol TM9SF2provided by HGNC Official Full Name transmembrane 9 superfamily member 2provided by HGNC Primary source HGNC:HGNC:11865 See related Ensembl:ENSG00000125304 MIM:604678; AllianceGenome:HGNC:11865 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P76; Lnc-PCIR Summary This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in thyroid (RPKM 79.3), colon (RPKM 75.9) and 25 other tissues See more Orthologs mouse all
TM9SF3, Official Symbol TM9SF3provided by HGNC Official Full Name transmembrane 9 superfamily member 3provided by HGNC Primary source HGNC:HGNC:21529 See related Ensembl:ENSG00000077147 MIM:616872; AllianceGenome:HGNC:21529 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMBP; EP70-P-iso Summary Predicted to be involved in protein localization to membrane. Predicted to be located in exocytic vesicle. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in stomach (RPKM 69.3), colon (RPKM 62.0) and 25 other tissues See more Orthologs mouse all
TM9SF4, Official Symbol TM9SF4provided by HGNC Official Full Name transmembrane 9 superfamily member 4provided by HGNC Primary source HGNC:HGNC:30797 See related Ensembl:ENSG00000101337 MIM:617727; AllianceGenome:HGNC:30797 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ836N17.2 Summary Involved in several processes, including positive regulation of protein localization; regulation of intracellular pH; and vacuolar proton-transporting V-type ATPase complex assembly. Located in Golgi apparatus and early endosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 20.7), brain (RPKM 16.4) and 25 other tissues See more Orthologs mouse all
TMA16, Official Symbol TMA16provided by HGNC Official Full Name translation machinery associated 16 homologprovided by HGNC Primary source HGNC:HGNC:25638 See related Ensembl:ENSG00000198498 AllianceGenome:HGNC:25638 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C4orf43 Summary Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 10.4), endometrium (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
TMA16P2, Official Symbol TMA16P2provided by HGNC Official Full Name translation machinery associated 16 homolog pseudogene 2provided by HGNC Primary source HGNC:HGNC:43781 See related AllianceGenome:HGNC:43781 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TMA7, Official Symbol TMA7provided by HGNC Official Full Name translation machinery associated 7 homologprovided by HGNC Primary source HGNC:HGNC:26932 See related Ensembl:ENSG00000232112 MIM:615808; AllianceGenome:HGNC:26932 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCDC72; HSPC016 Summary Predicted to be involved in cytoplasmic translation. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 126.7), bone marrow (RPKM 115.6) and 25 other tissues See more Orthologs mouse all
TMBIM1, Official Symbol TMBIM1provided by HGNC Official Full Name transmembrane BAX inhibitor motif containing 1provided by HGNC Primary source HGNC:HGNC:23410 See related Ensembl:ENSG00000135926 MIM:610364; AllianceGenome:HGNC:23410 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LFG3; RECS1; MST100; PP1201; MSTP100 Summary Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 69.4), fat (RPKM 68.5) and 25 other tissues See more Orthologs mouse all
TMBIM4, Official Symbol TMBIM4provided by HGNC Official Full Name transmembrane BAX inhibitor motif containing 4provided by HGNC Primary source HGNC:HGNC:24257 See related Ensembl:ENSG00000155957 MIM:616874; AllianceGenome:HGNC:24257 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S1R; GAAP; LFG4; ZPRO; CGI-119 Summary Involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Located in Golgi stack. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 40.4), testis (RPKM 37.8) and 25 other tissues See more Orthologs mouse all
TMBIM6, Official Symbol TMBIM6provided by HGNC Official Full Name transmembrane BAX inhibitor motif containing 6provided by HGNC Primary source HGNC:HGNC:11723 See related Ensembl:ENSG00000139644 MIM:600748; AllianceGenome:HGNC:11723 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BI-1; TEGT; BAXI1 Summary Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of RNA metabolic process; negative regulation of intrinsic apoptotic signaling pathway; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane and mitochondrial membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 392.9), liver (RPKM 352.7) and 25 other tissues See more Orthologs mouse all
TMBIM7P, Official Symbol TMBIM7Pprovided by HGNC Official Full Name transmembrane BAX inhibitor motif containing 7, pseudogeneprovided by HGNC Primary source HGNC:HGNC:49212 See related Ensembl:ENSG00000230927 AllianceGenome:HGNC:49212 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more Orthologs all
TMC1, Official Symbol TMC1provided by HGNC Official Full Name transmembrane channel like 1provided by HGNC Primary source HGNC:HGNC:16513 See related Ensembl:ENSG00000165091 MIM:606706; AllianceGenome:HGNC:16513 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB7; DFNA36; DFNB11 Summary This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
TMC2, Official Symbol TMC2provided by HGNC Official Full Name transmembrane channel like 2provided by HGNC Primary source HGNC:HGNC:16527 See related Ensembl:ENSG00000149488 MIM:606707; AllianceGenome:HGNC:16527 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C20orf145 Summary This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015] Expression Low expression observed in reference dataset See more Orthologs mouse all
TMC3, Official Symbol TMC3provided by HGNC Official Full Name transmembrane channel like 3provided by HGNC Primary source HGNC:HGNC:22995 See related Ensembl:ENSG00000188869 MIM:617196; AllianceGenome:HGNC:22995 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
TMC4, Official Symbol TMC4provided by HGNC Official Full Name transmembrane channel like 4provided by HGNC Primary source HGNC:HGNC:22998 See related Ensembl:ENSG00000167608 MIM:617181; AllianceGenome:HGNC:22998 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in duodenum (RPKM 27.9), colon (RPKM 25.4) and 14 other tissues See more Orthologs mouse all
TMC5, Official Symbol TMC5provided by HGNC Official Full Name transmembrane channel like 5provided by HGNC Primary source HGNC:HGNC:22999 See related Ensembl:ENSG00000103534 MIM:617197; AllianceGenome:HGNC:22999 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 21.9), stomach (RPKM 18.3) and 10 other tissues See more Orthologs mouse all
TMC6, Official Symbol TMC6provided by HGNC Official Full Name transmembrane channel like 6provided by HGNC Primary source HGNC:HGNC:18021 See related Ensembl:ENSG00000141524 MIM:605828; AllianceGenome:HGNC:18021 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EV1; lnc; EVER1; EVIN1; LAK-4P; TNRC6C-AS1 Summary Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 21.6), lymph node (RPKM 18.5) and 20 other tissues See more Orthologs mouse all
TMC7, Official Symbol TMC7provided by HGNC Official Full Name transmembrane channel like 7provided by HGNC Primary source HGNC:HGNC:23000 See related Ensembl:ENSG00000170537 MIM:617198; AllianceGenome:HGNC:23000 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 4.7), brain (RPKM 4.0) and 15 other tissues See more Orthologs mouse all
TMC8, Official Symbol TMC8provided by HGNC Official Full Name transmembrane channel like 8provided by HGNC Primary source HGNC:HGNC:20474 See related Ensembl:ENSG00000167895 MIM:605829; AllianceGenome:HGNC:20474 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EV2; EVER2; EVIN2 Summary Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 30.6), spleen (RPKM 30.0) and 9 other tissues See more Orthologs mouse all
TMCC1, Official Symbol TMCC1provided by HGNC Official Full Name transmembrane and coiled-coil domain family 1provided by HGNC Primary source HGNC:HGNC:29116 See related Ensembl:ENSG00000172765 MIM:616242; AllianceGenome:HGNC:29116 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.2), brain (RPKM 4.1) and 25 other tissues See more Orthologs mouse all
TMCC1-DT, Official Symbol TMCC1-DTprovided by HGNC Official Full Name TMCC1 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:49060 See related Ensembl:ENSG00000271270 AllianceGenome:HGNC:49060 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMCC1-AS1 Expression Ubiquitous expression in brain (RPKM 1.3), prostate (RPKM 0.6) and 25 other tissues See more
TMCC1P1, Official Symbol TMCC1P1provided by HGNC Official Full Name transmembrane and coiled-coil domain family 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:31901 See related AllianceGenome:HGNC:31901 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMCC1P
TMCC2, Official Symbol TMCC2provided by HGNC Official Full Name transmembrane and coiled-coil domain family 2provided by HGNC Primary source HGNC:HGNC:24239 See related Ensembl:ENSG00000133069 MIM:619429; AllianceGenome:HGNC:24239 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HUCEP11 Summary Involved in amyloid precursor protein metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 19.2), brain (RPKM 7.1) and 4 other tissues See more Orthologs mouse all
TMCC2-AS1, Official Symbol TMCC2-AS1provided by HGNC Official Full Name TMCC2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41042 See related AllianceGenome:HGNC:41042 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
TMCC3, Official Symbol TMCC3provided by HGNC Official Full Name transmembrane and coiled-coil domain family 3provided by HGNC Primary source HGNC:HGNC:29199 See related Ensembl:ENSG00000057704 MIM:617459; AllianceGenome:HGNC:29199 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables 14-3-3 protein binding activity and identical protein binding activity. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.1) and 24 other tissues See more Orthologs mouse all
TMCO1, Official Symbol TMCO1provided by HGNC Official Full Name transmembrane and coiled-coil domains 1provided by HGNC Primary source HGNC:HGNC:18188 See related Ensembl:ENSG00000143183 MIM:614123; AllianceGenome:HGNC:18188 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCIA3; TMCC4; CFSMR1; HP10122; PNAS-136 Summary This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial dysmorphism, skeletal anomalies, and cognitive disability. Mutations at this locus have also been associated with open angle glaucoma blindness. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in colon (RPKM 19.0), thyroid (RPKM 18.0) and 25 other tissues See more Orthologs mouse all
TMCO1-AS1, Official Symbol TMCO1-AS1provided by HGNC Official Full Name TMCO1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54046 See related AllianceGenome:HGNC:54046 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in thyroid (RPKM 2.7), colon (RPKM 2.6) and 17 other tissues See more
TMCO2, Official Symbol TMCO2provided by HGNC Official Full Name transmembrane and coiled-coil domains 2provided by HGNC Primary source HGNC:HGNC:23312 See related Ensembl:ENSG00000188800 AllianceGenome:HGNC:23312 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ39G22.2 Summary Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 44.1) See more Orthologs mouse all
TMCO3, Official Symbol TMCO3provided by HGNC Official Full Name transmembrane and coiled-coil domains 3provided by HGNC Primary source HGNC:HGNC:20329 See related Ensembl:ENSG00000150403 MIM:617134; AllianceGenome:HGNC:20329 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C13orf11 Summary This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in stomach (RPKM 5.5), endometrium (RPKM 4.4) and 25 other tissues See more Orthologs mouse all
TMCO4, Official Symbol TMCO4provided by HGNC Official Full Name transmembrane and coiled-coil domains 4provided by HGNC Primary source HGNC:HGNC:27393 See related Ensembl:ENSG00000162542 AllianceGenome:HGNC:27393 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 7.2), prostate (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
TMCO5A, Official Symbol TMCO5Aprovided by HGNC Official Full Name transmembrane and coiled-coil domains 5Aprovided by HGNC Primary source HGNC:HGNC:28558 See related Ensembl:ENSG00000166069 AllianceGenome:HGNC:28558 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMCO5 Summary Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 13.4) See more Orthologs mouse all
TMCO6, Official Symbol TMCO6provided by HGNC Official Full Name transmembrane and coiled-coil domains 6provided by HGNC Primary source HGNC:HGNC:28814 See related Ensembl:ENSG00000113119 AllianceGenome:HGNC:28814 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRO1580 Summary Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 7.0), kidney (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
TMDD1, Official Symbol TMDD1provided by HGNC Official Full Name transmembrane and death domain 1provided by HGNC Primary source HGNC:HGNC:53646 See related Ensembl:ENSG00000284730 AllianceGenome:HGNC:53646 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C12orf81; hCG1648055 Summary Predicted to be involved in signal transduction. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
TMED1, Official Symbol TMED1provided by HGNC Official Full Name transmembrane p24 trafficking protein 1provided by HGNC Primary source HGNC:HGNC:17291 See related Ensembl:ENSG00000099203 MIM:605395; AllianceGenome:HGNC:17291 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Tp24; p24g1; Il1rl1l; IL1RL1LG Summary This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in placenta (RPKM 10.9), kidney (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
TMED10, Official Symbol TMED10provided by HGNC Official Full Name transmembrane p24 trafficking protein 10provided by HGNC Primary source HGNC:HGNC:16998 See related Ensembl:ENSG00000170348 MIM:605406; AllianceGenome:HGNC:16998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA) Summary This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 111.9), endometrium (RPKM 61.7) and 25 other tissues See more Orthologs mouse all