psui3905/ncbi_genes_summary huggingface dataset:
STC1, Official Symbol STC1provided by HGNC Official Full Name stanniocalcin 1provided by HGNC Primary source HGNC:HGNC:11373 See related Ensembl:ENSG00000159167 MIM:601185; AllianceGenome:HGNC:11373 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STC Summary This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 33.6), thyroid (RPKM 19.7) and 14 other tissues See more Orthologs mouse all
STC2, Official Symbol STC2provided by HGNC Official Full Name stanniocalcin 2provided by HGNC Primary source HGNC:HGNC:11374 See related Ensembl:ENSG00000113739 MIM:603665; AllianceGenome:HGNC:11374 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STC-2; STCRP Summary This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 12.8), thyroid (RPKM 5.0) and 12 other tissues See more Orthologs mouse all
STEAP1, Official Symbol STEAP1provided by HGNC Official Full Name STEAP family member 1provided by HGNC Primary source HGNC:HGNC:11378 See related Ensembl:ENSG00000164647 MIM:604415; AllianceGenome:HGNC:11378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STEAP; PRSS24 Summary This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 54.6), appendix (RPKM 20.3) and 9 other tissues See more Orthologs mouse all
STEAP1B, Official Symbol STEAP1Bprovided by HGNC Official Full Name STEAP family member 1Bprovided by HGNC Primary source HGNC:HGNC:41907 See related Ensembl:ENSG00000105889 AllianceGenome:HGNC:41907 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in prostate (RPKM 3.5), appendix (RPKM 1.8) and 15 other tissues See more Orthologs all
STEAP2, Official Symbol STEAP2provided by HGNC Official Full Name STEAP2 metalloreductaseprovided by HGNC Primary source HGNC:HGNC:17885 See related Ensembl:ENSG00000157214 MIM:605094; AllianceGenome:HGNC:17885 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STMP; IPCA1; PUMPCn; STAMP1; PCANAP1 Summary This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues See more Orthologs mouse all
STEAP2-AS1, Official Symbol STEAP2-AS1provided by HGNC Official Full Name STEAP2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40820 See related Ensembl:ENSG00000227646 AllianceGenome:HGNC:40820 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
STEAP3, Official Symbol STEAP3provided by HGNC Official Full Name STEAP3 metalloreductaseprovided by HGNC Primary source HGNC:HGNC:24592 See related Ensembl:ENSG00000115107 MIM:609671; AllianceGenome:HGNC:24592 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STMP3; TSAP6; pHyde; AHMIO2; dudlin-2; dudulin-2 Summary This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] Expression Ubiquitous expression in liver (RPKM 27.2), duodenum (RPKM 11.9) and 23 other tissues See more Orthologs mouse all
STEAP3-AS1, Official Symbol STEAP3-AS1provided by HGNC Official Full Name STEAP3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41053 See related Ensembl:ENSG00000229867 AllianceGenome:HGNC:41053 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in liver (RPKM 3.2), duodenum (RPKM 1.5) and 23 other tissues See more
STEAP4, Official Symbol STEAP4provided by HGNC Official Full Name STEAP4 metalloreductaseprovided by HGNC Primary source HGNC:HGNC:21923 See related Ensembl:ENSG00000127954 MIM:611098; AllianceGenome:HGNC:21923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIARP; STAMP2; SchLAH; TNFAIP9 Summary The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] Expression Broad expression in fat (RPKM 50.0), prostate (RPKM 32.8) and 17 other tissues See more Orthologs mouse all
STEEP1, Official Symbol STEEP1provided by HGNC Official Full Name STING1 ER exit protein 1provided by HGNC Primary source HGNC:HGNC:26239 See related Ensembl:ENSG00000018610 MIM:301012; AllianceGenome:HGNC:26239 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STEEP; MRX107; CXorf56; XLID107 Summary While this gene is well-supported by transcript data, no functional information on its protein products is currently available. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in thyroid (RPKM 6.7), fat (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
STH, Official Symbol STHprovided by HGNC Official Full Name saitohinprovided by HGNC Primary source HGNC:HGNC:18839 See related Ensembl:ENSG00000256762 MIM:607067; AllianceGenome:HGNC:18839 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAPTIT Summary Involved in positive regulation of mRNA splicing, via spliceosome. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
STIL, Official Symbol STILprovided by HGNC Official Full Name STIL centriolar assembly proteinprovided by HGNC Primary source HGNC:HGNC:10879 See related Ensembl:ENSG00000123473 MIM:181590; AllianceGenome:HGNC:10879 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIL; MCPH7 Summary This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 3.3), bone marrow (RPKM 3.2) and 21 other tissues See more Orthologs mouse all
STIM1, Official Symbol STIM1provided by HGNC Official Full Name stromal interaction molecule 1provided by HGNC Primary source HGNC:HGNC:11386 See related Ensembl:ENSG00000167323 MIM:605921; AllianceGenome:HGNC:11386 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GOK; TAM; TAM1; IMD10; STRMK; D11S4896E Summary This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] Expression Ubiquitous expression in thyroid (RPKM 23.4), esophagus (RPKM 23.1) and 25 other tissues See more Orthologs mouse all
STIM1-AS1, Official Symbol STIM1-AS1provided by HGNC Official Full Name STIM1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40568 See related Ensembl:ENSG00000228661 AllianceGenome:HGNC:40568 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 1.2), brain (RPKM 1.1) and 25 other tissues See more
STIM2, Official Symbol STIM2provided by HGNC Official Full Name stromal interaction molecule 2provided by HGNC Primary source HGNC:HGNC:19205 See related Ensembl:ENSG00000109689 MIM:610841; AllianceGenome:HGNC:19205 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in gall bladder (RPKM 9.8), lymph node (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
STIMATE, Official Symbol STIMATEprovided by HGNC Official Full Name STIM activating enhancerprovided by HGNC Primary source HGNC:HGNC:30526 See related Ensembl:ENSG00000213533 MIM:617189; AllianceGenome:HGNC:30526 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMEM110 Summary Enables calcium channel regulator activity. Involved in activation of store-operated calcium channel activity; calcium-mediated signaling using intracellular calcium source; and positive regulation of calcineurin-NFAT signaling cascade. Located in cortical endoplasmic reticulum; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 12.1), lung (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
STIMATE-MUSTN1, Official Symbol STIMATE-MUSTN1provided by HGNC Official Full Name STIMATE-MUSTN1 readthroughprovided by HGNC Primary source HGNC:HGNC:38834 See related Ensembl:ENSG00000248592 AllianceGenome:HGNC:38834 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMEM110-MUSTN1 Summary This locus represents naturally occurring read-through transcription between the neighboring TMEM110 (transmembrane protein 110) and MUSTN1 (musculoskeletal, embryonic nuclear protein 1) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in lung (RPKM 19.9), prostate (RPKM 19.7) and 25 other tissues See more Orthologs all
STING1, Official Symbol STING1provided by HGNC Official Full Name stimulator of interferon response cGAMP interactor 1provided by HGNC Primary source HGNC:HGNC:27962 See related Ensembl:ENSG00000184584 MIM:612374; AllianceGenome:HGNC:27962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta Summary This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] Expression Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues See more Orthologs mouse all
STIP1, Official Symbol STIP1provided by HGNC Official Full Name stress induced phosphoprotein 1provided by HGNC Primary source HGNC:HGNC:11387 See related Ensembl:ENSG00000168439 MIM:605063; AllianceGenome:HGNC:11387 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521 Summary STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009] Expression Ubiquitous expression in testis (RPKM 66.9), adrenal (RPKM 34.3) and 25 other tissues See more Orthologs mouse all
STK10, Official Symbol STK10provided by HGNC Official Full Name serine/threonine kinase 10provided by HGNC Primary source HGNC:HGNC:11388 See related Ensembl:ENSG00000072786 MIM:603919; AllianceGenome:HGNC:11388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOK; PRO2729 Summary This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 23.3), bone marrow (RPKM 21.8) and 23 other tissues See more Orthologs mouse all
STK11, Official Symbol STK11provided by HGNC Official Full Name serine/threonine kinase 11provided by HGNC Primary source HGNC:HGNC:11389 See related Ensembl:ENSG00000118046 MIM:602216; AllianceGenome:HGNC:11389 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PJS; LKB1; hLKB1 Summary The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022] Expression Broad expression in testis (RPKM 28.3), spleen (RPKM 10.4) and 25 other tissues See more Orthologs mouse all
STK11IP, Official Symbol STK11IPprovided by HGNC Official Full Name serine/threonine kinase 11 interacting proteinprovided by HGNC Primary source HGNC:HGNC:19184 See related Ensembl:ENSG00000144589 MIM:607172; AllianceGenome:HGNC:19184 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIP1; LKB1IP; STK11IP1 Summary Enables protein kinase binding activity. Involved in protein localization. Located in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 10.6), spleen (RPKM 4.9) and 24 other tissues See more Orthologs mouse all
STK16, Official Symbol STK16provided by HGNC Official Full Name serine/threonine kinase 16provided by HGNC Primary source HGNC:HGNC:11394 See related Ensembl:ENSG00000115661 MIM:604719; AllianceGenome:HGNC:11394 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSK; KRCT; MPSK; TSF1; hPSK; PKL12 Summary Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.6), brain (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
STK17A, Official Symbol STK17Aprovided by HGNC Official Full Name serine/threonine kinase 17aprovided by HGNC Primary source HGNC:HGNC:11395 See related Ensembl:ENSG00000164543 MIM:604726; AllianceGenome:HGNC:11395 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRAK1 Summary This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 25.5), bone marrow (RPKM 15.3) and 24 other tissues See more Orthologs all
STK17B, Official Symbol STK17Bprovided by HGNC Official Full Name serine/threonine kinase 17bprovided by HGNC Primary source HGNC:HGNC:11396 See related Ensembl:ENSG00000081320 MIM:604727; AllianceGenome:HGNC:11396 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRAK2 Summary Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 54.0), lymph node (RPKM 45.0) and 18 other tissues See more Orthologs mouse all
STK19, Official Symbol STK19provided by HGNC Official Full Name serine/threonine kinase 19provided by HGNC Primary source HGNC:HGNC:11398 See related Ensembl:ENSG00000204344 MIM:604977; AllianceGenome:HGNC:11398 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G11; RP1; D6S60; D6S60E; HLA-RP1 Summary This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 19.3), testis (RPKM 9.7) and 25 other tissues See more Orthologs mouse all
STK24, Official Symbol STK24provided by HGNC Official Full Name serine/threonine kinase 24provided by HGNC Primary source HGNC:HGNC:11403 See related Ensembl:ENSG00000102572 MIM:604984; AllianceGenome:HGNC:11403 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST3; STK3; MST3B; STE20; HEL-S-95 Summary This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] Expression Ubiquitous expression in esophagus (RPKM 41.4), skin (RPKM 24.6) and 25 other tissues See more Orthologs mouse all
STK25, Official Symbol STK25provided by HGNC Official Full Name serine/threonine kinase 25provided by HGNC Primary source HGNC:HGNC:11404 See related Ensembl:ENSG00000115694 MIM:602255; AllianceGenome:HGNC:11404 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SOK1; YSK1 Summary This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in brain (RPKM 17.8), thyroid (RPKM 17.1) and 25 other tissues See more Orthologs mouse all
STK25P1, Official Symbol STK25P1provided by HGNC Official Full Name serine/threonine kinase 25 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50361 See related AllianceGenome:HGNC:50361 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
STK26, Official Symbol STK26provided by HGNC Official Full Name serine/threonine kinase 26provided by HGNC Primary source HGNC:HGNC:18174 See related Ensembl:ENSG00000134602 MIM:300547; AllianceGenome:HGNC:18174 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MASK; MST4 Summary The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues See more Orthologs mouse all
STK3, Official Symbol STK3provided by HGNC Official Full Name serine/threonine kinase 3provided by HGNC Primary source HGNC:HGNC:11406 See related Ensembl:ENSG00000104375 MIM:605030; AllianceGenome:HGNC:11406 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRS1; MST2 Summary This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in endometrium (RPKM 3.0), placenta (RPKM 2.4) and 25 other tissues See more Orthologs mouse all
STK31, Official Symbol STK31provided by HGNC Official Full Name serine/threonine kinase 31provided by HGNC Primary source HGNC:HGNC:11407 See related Ensembl:ENSG00000196335 MIM:605790; AllianceGenome:HGNC:11407 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TDRD8; SGK396 Summary This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 35.6) See more Orthologs mouse all
STK32A, Official Symbol STK32Aprovided by HGNC Official Full Name serine/threonine kinase 32Aprovided by HGNC Primary source HGNC:HGNC:28317 See related Ensembl:ENSG00000169302 AllianceGenome:HGNC:28317 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YANK1 Summary Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in adrenal (RPKM 5.1), thyroid (RPKM 4.8) and 21 other tissues See more Orthologs mouse all
STK32B, Official Symbol STK32Bprovided by HGNC Official Full Name serine/threonine kinase 32Bprovided by HGNC Primary source HGNC:HGNC:14217 See related Ensembl:ENSG00000152953 AllianceGenome:HGNC:14217 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STK32; STKG6; YANK2; HSA250839 Summary This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Broad expression in kidney (RPKM 2.0), testis (RPKM 1.4) and 14 other tissues See more Orthologs mouse all
STK32C, Official Symbol STK32Cprovided by HGNC Official Full Name serine/threonine kinase 32Cprovided by HGNC Primary source HGNC:HGNC:21332 See related Ensembl:ENSG00000165752 AllianceGenome:HGNC:21332 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKE; YANK3 Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Broad expression in brain (RPKM 5.0), testis (RPKM 3.2) and 22 other tissues See more Orthologs mouse all
STK33, Official Symbol STK33provided by HGNC Official Full Name serine/threonine kinase 33provided by HGNC Primary source HGNC:HGNC:14568 See related Ensembl:ENSG00000130413 MIM:607670; AllianceGenome:HGNC:14568 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and protein autophosphorylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 7.0), thyroid (RPKM 2.1) and 11 other tissues See more Orthologs mouse all
STK33P1, Official Symbol STK33P1provided by HGNC Official Full Name serine/threonine kinase 33 pseudogene 1provided by HGNC Primary source HGNC:HGNC:26871 See related Ensembl:ENSG00000227412 AllianceGenome:HGNC:26871 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STK33P; STK33ps
STK35, Official Symbol STK35provided by HGNC Official Full Name serine/threonine kinase 35provided by HGNC Primary source HGNC:HGNC:16254 See related Ensembl:ENSG00000125834 MIM:609370; AllianceGenome:HGNC:16254 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLIK1; STK35L1 Summary The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 8.0), esophagus (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
STK36, Official Symbol STK36provided by HGNC Official Full Name serine/threonine kinase 36provided by HGNC Primary source HGNC:HGNC:17209 See related Ensembl:ENSG00000163482 MIM:607652; AllianceGenome:HGNC:17209 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FU; CILD46 Summary This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 24.8), gall bladder (RPKM 6.4) and 21 other tissues See more Orthologs mouse all
STK38, Official Symbol STK38provided by HGNC Official Full Name serine/threonine kinase 38provided by HGNC Primary source HGNC:HGNC:17847 See related Ensembl:ENSG00000112079 MIM:606964; AllianceGenome:HGNC:17847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDR; NDR1 Summary This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] Expression Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues See more Orthologs mouse all
STK38L, Official Symbol STK38Lprovided by HGNC Official Full Name serine/threonine kinase 38 likeprovided by HGNC Primary source HGNC:HGNC:17848 See related Ensembl:ENSG00000211455 MIM:615836; AllianceGenome:HGNC:17848 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDR2 Summary Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 16.1), heart (RPKM 15.2) and 25 other tissues See more Orthologs mouse all
STK39, Official Symbol STK39provided by HGNC Official Full Name serine/threonine kinase 39provided by HGNC Primary source HGNC:HGNC:17717 See related Ensembl:ENSG00000198648 MIM:607648; AllianceGenome:HGNC:17717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCHT; PASK; SPAK Summary This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 10.6), esophagus (RPKM 7.1) and 23 other tissues See more Orthologs mouse all
STK4, Official Symbol STK4provided by HGNC Official Full Name serine/threonine kinase 4provided by HGNC Primary source HGNC:HGNC:11408 See related Ensembl:ENSG00000101109 MIM:604965; AllianceGenome:HGNC:11408 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KRS2; MST1; YSK3 Summary The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008] Annotation information Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018] Expression Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues See more Orthologs mouse all
STK40, Official Symbol STK40provided by HGNC Official Full Name serine/threonine kinase 40provided by HGNC Primary source HGNC:HGNC:21373 See related Ensembl:ENSG00000196182 MIM:609437; AllianceGenome:HGNC:21373 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SHIK; SgK495 Summary Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 28.4), ovary (RPKM 17.2) and 25 other tissues See more Orthologs mouse all
STKLD1, Official Symbol STKLD1provided by HGNC Official Full Name serine/threonine kinase like domain containing 1provided by HGNC Primary source HGNC:HGNC:28669 See related Ensembl:ENSG00000198870 MIM:618530; AllianceGenome:HGNC:28669 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Sk521; SgK071; C9orf96 Summary Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 4.5), brain (RPKM 0.4) and 2 other tissues See more Orthologs mouse all
STMN1, Official Symbol STMN1provided by HGNC Official Full Name stathmin 1provided by HGNC Primary source HGNC:HGNC:6510 See related Ensembl:ENSG00000117632 MIM:151442; AllianceGenome:HGNC:6510 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215 Summary This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] Expression Broad expression in brain (RPKM 118.2), testis (RPKM 64.4) and 20 other tissues See more Orthologs mouse all
STMN2, Official Symbol STMN2provided by HGNC Official Full Name stathmin 2provided by HGNC Primary source HGNC:HGNC:10577 See related Ensembl:ENSG00000104435 MIM:600621; AllianceGenome:HGNC:10577 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCG10; SCGN10 Summary This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010] Expression Biased expression in brain (RPKM 155.5) and adrenal (RPKM 33.4) See more Orthologs mouse all
STMN3, Official Symbol STMN3provided by HGNC Official Full Name stathmin 3provided by HGNC Primary source HGNC:HGNC:15926 See related Ensembl:ENSG00000197457 MIM:608362; AllianceGenome:HGNC:15926 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCLIP Summary This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] Expression Broad expression in brain (RPKM 62.0), thyroid (RPKM 16.1) and 20 other tissues See more Orthologs mouse all