psui3905/ncbi_genes_summary huggingface dataset:
FOXB1, Official Symbol FOXB1provided by HGNC Official Full Name forkhead box B1provided by HGNC Primary source HGNC:HGNC:3799 See related Ensembl:ENSG00000171956 MIM:619961; AllianceGenome:HGNC:3799 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKH5; HFKH-5 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including mammary gland development; nervous system development; and visual learning. Predicted to act upstream of or within spinal cord development; thalamus development; and urogenital system development. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
FOXB2, Official Symbol FOXB2provided by HGNC Official Full Name forkhead box B2provided by HGNC Primary source HGNC:HGNC:23315 See related Ensembl:ENSG00000204612 MIM:619962; AllianceGenome:HGNC:23315 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKH4; bA159H20.4 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
FOXC1, Official Symbol FOXC1provided by HGNC Official Full Name forkhead box C1provided by HGNC Primary source HGNC:HGNC:3800 See related Ensembl:ENSG00000054598 MIM:601090; AllianceGenome:HGNC:3800 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARA; IGDA; IHG1; ASGD3; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3 Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008] Orthologs mouse all
FOXC2, Official Symbol FOXC2provided by HGNC Official Full Name forkhead box C2provided by HGNC Primary source HGNC:HGNC:3801 See related Ensembl:ENSG00000176692 MIM:602402; AllianceGenome:HGNC:3801 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LD; MFH1; MFH-1; FKHL14 Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008] Orthologs mouse all
FOXD1, Official Symbol FOXD1provided by HGNC Official Full Name forkhead box D1provided by HGNC Primary source HGNC:HGNC:3802 See related Ensembl:ENSG00000251493 MIM:601091; AllianceGenome:HGNC:3802 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHL8; FREAC4; FREAC-4 Summary This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014] Orthologs mouse all
FOXD2, Official Symbol FOXD2provided by HGNC Official Full Name forkhead box D2provided by HGNC Primary source HGNC:HGNC:3803 See related Ensembl:ENSG00000186564 MIM:602211; AllianceGenome:HGNC:3803 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHL17; FREAC9; FREAC-9 Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008] Orthologs mouse all
FOXD2-AS1, Official Symbol FOXD2-AS1provided by HGNC Official Full Name FOXD2 adjacent opposite strand RNA 1provided by HGNC Primary source HGNC:HGNC:44256 See related Ensembl:ENSG00000237424 AllianceGenome:HGNC:44256 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FOXD3, Official Symbol FOXD3provided by HGNC Official Full Name forkhead box D3provided by HGNC Primary source HGNC:HGNC:3804 See related Ensembl:ENSG00000187140 MIM:611539; AllianceGenome:HGNC:3804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIS1; HFH2; VAMAS2; Genesis Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] Orthologs mouse all
FOXD3-AS1, Official Symbol FOXD3-AS1provided by HGNC Official Full Name FOXD3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40241 See related Ensembl:ENSG00000230798 AllianceGenome:HGNC:40241 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAST; pasFOXD3 Expression Biased expression in testis (RPKM 1.8), prostate (RPKM 0.5) and 11 other tissues See more
FOXD4, Official Symbol FOXD4provided by HGNC Official Full Name forkhead box D4provided by HGNC Primary source HGNC:HGNC:3805 See related Ensembl:ENSG00000170122 MIM:601092; AllianceGenome:HGNC:3805 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHL9; FOXD4A; FREAC5; FREAC-5 Summary This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012] Orthologs mouse all
FOXD4L1, Official Symbol FOXD4L1provided by HGNC Official Full Name forkhead box D4 like 1provided by HGNC Primary source HGNC:HGNC:18521 See related Ensembl:ENSG00000184492 MIM:611084; AllianceGenome:HGNC:18521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXD5; bA395L14.1 Summary This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. [provided by RefSeq, Jul 2008] Orthologs all
FOXD4L3, Official Symbol FOXD4L3provided by HGNC Official Full Name forkhead box D4 like 3provided by HGNC Primary source HGNC:HGNC:18523 See related Ensembl:ENSG00000187559 MIM:611086; AllianceGenome:HGNC:18523 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXD6; FOXD4B; FOXD4L2; FOXD4L4 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
FOXD4L4, Official Symbol FOXD4L4provided by HGNC Official Full Name forkhead box D4 like 4provided by HGNC Primary source HGNC:HGNC:23762 See related Ensembl:ENSG00000184659 MIM:611085; AllianceGenome:HGNC:23762 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXD4b; FOXD4L2; bA460E7.2 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
FOXD4L5, Official Symbol FOXD4L5provided by HGNC Official Full Name forkhead box D4 like 5provided by HGNC Primary source HGNC:HGNC:18522 See related Ensembl:ENSG00000204779 AllianceGenome:HGNC:18522 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bA15J10.2 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
FOXD4L6, Official Symbol FOXD4L6provided by HGNC Official Full Name forkhead box D4 like 6provided by HGNC Primary source HGNC:HGNC:31986 See related Ensembl:ENSG00000273514 AllianceGenome:HGNC:31986 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
FOXE1, Official Symbol FOXE1provided by HGNC Official Full Name forkhead box E1provided by HGNC Primary source HGNC:HGNC:3806 See related Ensembl:ENSG00000178919 MIM:602617; AllianceGenome:HGNC:3806 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTF2; FOXE2; HFKH4; HFKL5; NMTC4; TITF2; TTF-2; BAMLAZ; FKHL15 Summary This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016] Annotation information Note: TTF2 (Gene ID: 8458) and FOXE1 (Gene ID: 2304) share the TTF2 symbol/alias in common. TTF2 is a widely used alternative name for forkhead box E1 (FOXE1), which can be confused with the official symbol for transcription termination factor 2 (TTF2). [31 May 2018] Orthologs mouse all
FOXE3, Official Symbol FOXE3provided by HGNC Official Full Name forkhead box E3provided by HGNC Primary source HGNC:HGNC:3808 See related Ensembl:ENSG00000186790 MIM:601094; AllianceGenome:HGNC:3808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAT11; ASGD2; CATC3; FKHL12; FREAC8; CTRCT34 Summary This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009] Orthologs mouse all
FOXF1, Official Symbol FOXF1provided by HGNC Official Full Name forkhead box F1provided by HGNC Primary source HGNC:HGNC:3809 See related Ensembl:ENSG00000103241 MIM:601089; AllianceGenome:HGNC:3809 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHL5; ACDMPV; FREAC1 Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 22.1), urinary bladder (RPKM 21.5) and 12 other tissues See more Orthologs mouse all
FOXF2, Official Symbol FOXF2provided by HGNC Official Full Name forkhead box F2provided by HGNC Primary source HGNC:HGNC:3810 See related Ensembl:ENSG00000137273 MIM:603250; AllianceGenome:HGNC:3810 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHL6; FREAC2; FREAC-2 Summary FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 8.4), prostate (RPKM 6.0) and 13 other tissues See more Orthologs mouse all
FOXG1, Official Symbol FOXG1provided by HGNC Official Full Name forkhead box G1provided by HGNC Primary source HGNC:HGNC:3811 See related Ensembl:ENSG00000176165 MIM:164874; AllianceGenome:HGNC:3811 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BF1; BF2; QIN; FKH2; HBF2; HFK1; HFK2; HFK3; KHL2; FHKL3; FKHL1; FKHL2; FKHL3; FKHL4; HBF-1; HBF-2; HBF-3; FOXG1A; FOXG1B; FOXG1C; HBF-G2 Summary This locus encodes a member of the fork-head transcription factor family. The encoded protein, which functions as a transcriptional repressor, is highly expressed in neural tissues during brain development. Mutations at this locus have been associated with Rett syndrome and a diverse spectrum of neurodevelopmental disorders defined as part of the FOXG1 syndrome. This gene is disregulated in many types of cancer and is the target of multiple microRNAs that regulate the proliferation of tumor cells. [provided by RefSeq, Jul 2020] Orthologs mouse all
FOXG1-AS1, Official Symbol FOXG1-AS1provided by HGNC Official Full Name FOXG1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50663 See related AllianceGenome:HGNC:50663 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXG1-AS Expression Low expression observed in reference dataset See more
FOXH1, Official Symbol FOXH1provided by HGNC Official Full Name forkhead box H1provided by HGNC Primary source HGNC:HGNC:3814 See related Ensembl:ENSG00000160973 MIM:603621; AllianceGenome:HGNC:3814 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAST1; FAST-1 Summary FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008] Expression Broad expression in skin (RPKM 10.3), brain (RPKM 5.3) and 22 other tissues See more Orthologs mouse all
FOXI1, Official Symbol FOXI1provided by HGNC Official Full Name forkhead box I1provided by HGNC Primary source HGNC:HGNC:3815 See related Ensembl:ENSG00000168269 MIM:601093; AllianceGenome:HGNC:3815 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6 Summary This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. [provided by RefSeq, Jan 2017] Expression Biased expression in kidney (RPKM 10.3), salivary gland (RPKM 2.7) and 1 other tissue See more Orthologs mouse all
FOXI2, Official Symbol FOXI2provided by HGNC Official Full Name forkhead box I2provided by HGNC Primary source HGNC:HGNC:32448 See related Ensembl:ENSG00000186766 MIM:617202; AllianceGenome:HGNC:32448 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 1.0), esophagus (RPKM 0.4) and 11 other tissues See more Orthologs mouse all
FOXI3, Official Symbol FOXI3provided by HGNC Official Full Name forkhead box I3provided by HGNC Primary source HGNC:HGNC:35123 See related Ensembl:ENSG00000214336 MIM:612351; AllianceGenome:HGNC:35123 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CFM2 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward placenta (RPKM 3.1) See more Orthologs mouse all
FOXJ1, Official Symbol FOXJ1provided by HGNC Official Full Name forkhead box J1provided by HGNC Primary source HGNC:HGNC:3816 See related Ensembl:ENSG00000129654 MIM:602291; AllianceGenome:HGNC:3816 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HFH4; HFH-4; CILD43; FKHL13 Summary This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009] Expression Biased expression in lung (RPKM 6.3), testis (RPKM 5.4) and 8 other tissues See more Orthologs mouse all
FOXJ2, Official Symbol FOXJ2provided by HGNC Official Full Name forkhead box J2provided by HGNC Primary source HGNC:HGNC:24818 See related Ensembl:ENSG00000065970 MIM:619162; AllianceGenome:HGNC:24818 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHX Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 8.4), ovary (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
FOXJ3, Official Symbol FOXJ3provided by HGNC Official Full Name forkhead box J3provided by HGNC Primary source HGNC:HGNC:29178 See related Ensembl:ENSG00000198815 MIM:616035; AllianceGenome:HGNC:29178 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 10.6), testis (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
FOXK1, Official Symbol FOXK1provided by HGNC Official Full Name forkhead box K1provided by HGNC Primary source HGNC:HGNC:23480 See related Ensembl:ENSG00000164916 MIM:616302; AllianceGenome:HGNC:23480 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXK1L Summary Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 5.1), testis (RPKM 3.8) and 25 other tissues See more Orthologs mouse all
FOXK2, Official Symbol FOXK2provided by HGNC Official Full Name forkhead box K2provided by HGNC Primary source HGNC:HGNC:6036 See related Ensembl:ENSG00000141568 MIM:147685; AllianceGenome:HGNC:6036 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILF; ILF1; ILF-1; nGTBP Summary The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 11.2), brain (RPKM 8.3) and 25 other tissues See more Orthologs mouse all
FOXL1, Official Symbol FOXL1provided by HGNC Official Full Name forkhead box L1provided by HGNC Primary source HGNC:HGNC:3817 See related Ensembl:ENSG00000176678 MIM:603252; AllianceGenome:HGNC:3817 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKH6; FKHL11; FREAC7 Summary This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012] Orthologs mouse all
FOXL2, Official Symbol FOXL2provided by HGNC Official Full Name forkhead box L2provided by HGNC Primary source HGNC:HGNC:1092 See related Ensembl:ENSG00000183770 MIM:605597; AllianceGenome:HGNC:1092 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPES; PFRK; POF3; BPES1; PINTO Summary This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016] Orthologs mouse all
FOXL2NB, Official Symbol FOXL2NBprovided by HGNC Official Full Name FOXL2 neighborprovided by HGNC Primary source HGNC:HGNC:34428 See related Ensembl:ENSG00000206262 AllianceGenome:HGNC:34428 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3orf72 Summary Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in ovary (RPKM 15.2) and endometrium (RPKM 8.8) See more Orthologs all
FOXL3, Official Symbol FOXL3provided by HGNC Official Full Name forkhead box L3provided by HGNC Primary source HGNC:HGNC:54201 See related Ensembl:ENSG00000248767 AllianceGenome:HGNC:54201 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
FOXM1, Official Symbol FOXM1provided by HGNC Official Full Name forkhead box M1provided by HGNC Primary source HGNC:HGNC:3818 See related Ensembl:ENSG00000111206 MIM:602341; AllianceGenome:HGNC:3818 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; TRIDENT; MPHOSPH2 Summary The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] Expression Broad expression in testis (RPKM 16.1), bone marrow (RPKM 11.2) and 16 other tissues See more Orthologs mouse all
FOXN1, Official Symbol FOXN1provided by HGNC Official Full Name forkhead box N1provided by HGNC Primary source HGNC:HGNC:12765 See related Ensembl:ENSG00000109101 MIM:600838; AllianceGenome:HGNC:12765 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WHN; RONU; TLIND; FKHL20; TIDAND Summary Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 9.7) and esophagus (RPKM 2.5) See more Orthologs mouse all
FOXN2, Official Symbol FOXN2provided by HGNC Official Full Name forkhead box N2provided by HGNC Primary source HGNC:HGNC:5281 See related Ensembl:ENSG00000170802 MIM:143089; AllianceGenome:HGNC:5281 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTLF Summary This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 14.2), fat (RPKM 8.5) and 24 other tissues See more Orthologs mouse all
FOXN3, Official Symbol FOXN3provided by HGNC Official Full Name forkhead box N3provided by HGNC Primary source HGNC:HGNC:1928 See related Ensembl:ENSG00000053254 MIM:602628; AllianceGenome:HGNC:1928 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHES1; PRO1635; C14orf116 Summary This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 25.7), ovary (RPKM 24.3) and 25 other tissues See more Orthologs mouse all
FOXN3-AS1, Official Symbol FOXN3-AS1provided by HGNC Official Full Name FOXN3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44290 See related Ensembl:ENSG00000258920 AllianceGenome:HGNC:44290 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in fat (RPKM 1.7), ovary (RPKM 1.6) and 25 other tissues See more
FOXN3-AS2, Official Symbol FOXN3-AS2provided by HGNC Official Full Name FOXN3 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:30119 See related Ensembl:ENSG00000259073 AllianceGenome:HGNC:30119 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRO1768
FOXN3P1, Official Symbol FOXN3P1provided by HGNC Official Full Name forkhead box N3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:43882 See related Ensembl:ENSG00000176318 AllianceGenome:HGNC:43882 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FOXN3P2, Official Symbol FOXN3P2provided by HGNC Official Full Name FOXN3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:54995 See related AllianceGenome:HGNC:54995 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FOXN4, Official Symbol FOXN4provided by HGNC Official Full Name forkhead box N4provided by HGNC Primary source HGNC:HGNC:21399 See related Ensembl:ENSG00000139445 MIM:609429; AllianceGenome:HGNC:21399 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008] Expression Restricted expression toward testis (RPKM 2.5) See more Orthologs mouse all
FOXO1, Official Symbol FOXO1provided by HGNC Official Full Name forkhead box O1provided by HGNC Primary source HGNC:HGNC:3819 See related Ensembl:ENSG00000150907 MIM:136533; AllianceGenome:HGNC:3819 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKH1; FKHR; FOXO1A Summary This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 20.0), fat (RPKM 16.9) and 25 other tissues See more Orthologs mouse all
FOXO1B, Official Symbol FOXO1Bprovided by HGNC Official Full Name forkhead box O1B (pseudogene)provided by HGNC Primary source HGNC:HGNC:3820 See related Ensembl:ENSG00000214295 AllianceGenome:HGNC:3820 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHRP1
FOXO3, Official Symbol FOXO3provided by HGNC Official Full Name forkhead box O3provided by HGNC Primary source HGNC:HGNC:3821 See related Ensembl:ENSG00000118689 MIM:602681; AllianceGenome:HGNC:3821 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2 Summary This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 14.1), bone marrow (RPKM 13.9) and 25 other tissues See more Orthologs mouse all
FOXO3B, Official Symbol FOXO3Bprovided by HGNC Official Full Name forkhead box O3Bprovided by HGNC Primary source HGNC:HGNC:3822 See related Ensembl:ENSG00000240445 MIM:620471; AllianceGenome:HGNC:3822 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF286C; FKHRL1P1 Summary Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
FOXO4, Official Symbol FOXO4provided by HGNC Official Full Name forkhead box O4provided by HGNC Primary source HGNC:HGNC:7139 See related Ensembl:ENSG00000184481 MIM:300033; AllianceGenome:HGNC:7139 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AFX; AFX1; MLLT7 Summary This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] Expression Broad expression in placenta (RPKM 74.9), testis (RPKM 15.0) and 21 other tissues See more Orthologs mouse all
FOXO6, Official Symbol FOXO6provided by HGNC Official Full Name forkhead box O6provided by HGNC Primary source HGNC:HGNC:24814 See related Ensembl:ENSG00000204060 MIM:611457; AllianceGenome:HGNC:24814 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of dendritic spine development and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Annotation category: suggests misassembly Expression Broad expression in brain (RPKM 1.8), ovary (RPKM 1.5) and 21 other tissues See more Orthologs mouse all
FOXO6-AS1, Official Symbol FOXO6-AS1provided by HGNC Official Full Name FOXO6 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41066 See related Ensembl:ENSG00000229901 AllianceGenome:HGNC:41066 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FOXP1, Official Symbol FOXP1provided by HGNC Official Full Name forkhead box P1provided by HGNC Primary source HGNC:HGNC:3823 See related Ensembl:ENSG00000114861 MIM:605515; AllianceGenome:HGNC:3823 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MFH; QRF1; 12CC4; hFKH1B; HSPC215 Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
FOXP1-AS1, Official Symbol FOXP1-AS1provided by HGNC Official Full Name FOXP1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41942 See related Ensembl:ENSG00000244203 AllianceGenome:HGNC:41942 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.1) See more
FOXP2, Official Symbol FOXP2provided by HGNC Official Full Name forkhead box P2provided by HGNC Primary source HGNC:HGNC:13875 See related Ensembl:ENSG00000128573 MIM:605317; AllianceGenome:HGNC:13875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPCH1; CAGH44; TNRC10 Summary This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] Expression Ubiquitous expression in ovary (RPKM 3.6), endometrium (RPKM 3.4) and 22 other tissues See more Orthologs mouse all
FOXP3, Official Symbol FOXP3provided by HGNC Official Full Name forkhead box P3provided by HGNC Primary source HGNC:HGNC:6106 See related Ensembl:ENSG00000049768 MIM:300292; AllianceGenome:HGNC:6106 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JM2; AIID; IPEX; PIDX; XPID; DIETER Summary The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in appendix (RPKM 2.2), lymph node (RPKM 1.8) and 25 other tissues See more Orthologs mouse all
FOXP4, Official Symbol FOXP4provided by HGNC Official Full Name forkhead box P4provided by HGNC Primary source HGNC:HGNC:20842 See related Ensembl:ENSG00000137166 MIM:608924; AllianceGenome:HGNC:20842 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hFKHLA Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Ubiquitous expression in stomach (RPKM 7.0), testis (RPKM 4.6) and 25 other tissues See more Orthologs mouse all