psui3905/ncbi_genes_summary huggingface dataset:
USB1, Official Symbol USB1provided by HGNC Official Full Name U6 snRNA biogenesis phosphodiesterase 1provided by HGNC Primary source HGNC:HGNC:25792 See related Ensembl:ENSG00000103005 MIM:613276; AllianceGenome:HGNC:25792 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PN; Mpn1; HVSL1; hMpn1; hUsb1; C16orf57 Summary This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011] Expression Ubiquitous expression in appendix (RPKM 7.3), bone marrow (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
USE1, Official Symbol USE1provided by HGNC Official Full Name unconventional SNARE in the ER 1provided by HGNC Primary source HGNC:HGNC:30882 See related Ensembl:ENSG00000053501 MIM:610675; AllianceGenome:HGNC:30882 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D12; P31; SLT1; MDS032 Summary Predicted to enable SNAP receptor activity. Predicted to be involved in several processes, including lysosomal transport; protein catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 7.1), fat (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
USF1, Official Symbol USF1provided by HGNC Official Full Name upstream transcription factor 1provided by HGNC Primary source HGNC:HGNC:12593 See related Ensembl:ENSG00000158773 MIM:191523; AllianceGenome:HGNC:12593 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11 Summary This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] Expression Ubiquitous expression in spleen (RPKM 29.9), lymph node (RPKM 25.8) and 25 other tissues See more Orthologs mouse all
USF1P1, Official Symbol USF1P1provided by HGNC Official Full Name upstream transcription factor 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:23773 See related Ensembl:ENSG00000226501 AllianceGenome:HGNC:23773 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USF1P
USF2, Official Symbol USF2provided by HGNC Official Full Name upstream transcription factor 2, c-fos interactingprovided by HGNC Primary source HGNC:HGNC:12594 See related Ensembl:ENSG00000105698 MIM:600390; AllianceGenome:HGNC:12594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIP; bHLHb12 Summary This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in fat (RPKM 22.6), spleen (RPKM 20.0) and 25 other tissues See more Orthologs mouse all
USF3, Official Symbol USF3provided by HGNC Official Full Name upstream transcription factor family member 3provided by HGNC Primary source HGNC:HGNC:30494 See related Ensembl:ENSG00000176542 MIM:617568; AllianceGenome:HGNC:30494 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA2018 Summary This gene encodes a large protein that contains a helix-loop-helix domain and a polyglutamine region. A deletion in the polyglutamine region was associated with risk for thyroid carcinoma. [provided by RefSeq, May 2017] Expression Ubiquitous expression in bone marrow (RPKM 3.4), kidney (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
USH1C, Official Symbol USH1Cprovided by HGNC Official Full Name USH1 protein network component harmoninprovided by HGNC Primary source HGNC:HGNC:12597 See related Ensembl:ENSG00000006611 MIM:605242; AllianceGenome:HGNC:12597 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDZ73; AIE-75; DFNB18; PDZ-45; PDZ-73; PDZD7C; DFNB18A; NY-CO-37; NY-CO-38; ush1cpst; PDZ-73/NY-CO-38 Summary This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Biased expression in small intestine (RPKM 13.7), duodenum (RPKM 13.0) and 6 other tissues See more Orthologs mouse all
USH1G, Official Symbol USH1Gprovided by HGNC Official Full Name USH1 protein network component sansprovided by HGNC Primary source HGNC:HGNC:16356 See related Ensembl:ENSG00000182040 MIM:607696; AllianceGenome:HGNC:16356 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SANS; ANKS4A Summary This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with Usher syndrome type 1G (USH1G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Biased expression in esophagus (RPKM 1.1), skin (RPKM 0.6) and 6 other tissues See more Orthologs mouse all
USH2A, Official Symbol USH2Aprovided by HGNC Official Full Name usherinprovided by HGNC Primary source HGNC:HGNC:12601 See related Ensembl:ENSG00000042781 MIM:608400; AllianceGenome:HGNC:12601 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as US2; RP39; USH2; dJ1111A8.1 Summary This gene encodes a protein that contains laminin EGF motifs, a pentaxin domain, and many fibronectin type III motifs. The protein is found in the basement membrane, and may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIa and retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] Expression Biased expression in liver (RPKM 1.7), testis (RPKM 0.3) and 1 other tissue See more Orthologs mouse all
USH2A-AS1, Official Symbol USH2A-AS1provided by HGNC Official Full Name USH2A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40606 See related AllianceGenome:HGNC:40606 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
USH2A-AS2, Official Symbol USH2A-AS2provided by HGNC Official Full Name USH2A antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40605 See related Ensembl:ENSG00000233620 AllianceGenome:HGNC:40605 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.2) See more
USHBP1, Official Symbol USHBP1provided by HGNC Official Full Name USH1 protein network component harmonin binding protein 1provided by HGNC Primary source HGNC:HGNC:24058 See related Ensembl:ENSG00000130307 MIM:611810; AllianceGenome:HGNC:24058 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCC2; AIEBP Summary Enables PDZ domain binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 5.8), lung (RPKM 4.1) and 21 other tissues See more Orthologs mouse all
USO1, Official Symbol USO1provided by HGNC Official Full Name USO1 vesicle transport factorprovided by HGNC Primary source HGNC:HGNC:30904 See related Ensembl:ENSG00000138768 MIM:603344; AllianceGenome:HGNC:30904 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAP; VDP; P115 Summary The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in thyroid (RPKM 38.1), testis (RPKM 30.9) and 25 other tissues See more Orthologs mouse all
USP1, Official Symbol USP1provided by HGNC Official Full Name ubiquitin specific peptidase 1provided by HGNC Primary source HGNC:HGNC:12607 See related Ensembl:ENSG00000162607 MIM:603478; AllianceGenome:HGNC:12607 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBP Summary This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 29.9), bone marrow (RPKM 17.7) and 25 other tissues See more Orthologs mouse all
USP10, Official Symbol USP10provided by HGNC Official Full Name ubiquitin specific peptidase 10provided by HGNC Primary source HGNC:HGNC:12608 See related Ensembl:ENSG00000103194 MIM:609818; AllianceGenome:HGNC:12608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBPO Summary Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in placenta (RPKM 15.2), lymph node (RPKM 13.4) and 25 other tissues See more Orthologs mouse all
USP11, Official Symbol USP11provided by HGNC Official Full Name ubiquitin specific peptidase 11provided by HGNC Primary source HGNC:HGNC:12609 See related Ensembl:ENSG00000102226 MIM:300050; AllianceGenome:HGNC:12609 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UHX1 Summary Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 81.8), ovary (RPKM 32.3) and 22 other tissues See more Orthologs mouse all
USP12, Official Symbol USP12provided by HGNC Official Full Name ubiquitin specific peptidase 12provided by HGNC Primary source HGNC:HGNC:20485 See related Ensembl:ENSG00000152484 MIM:603091; AllianceGenome:HGNC:20485 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBH1; USP12L1 Summary Enables cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 15.7), lymph node (RPKM 15.4) and 25 other tissues See more Orthologs mouse all
USP12-AS1, Official Symbol USP12-AS1provided by HGNC Official Full Name USP12 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39961 See related AllianceGenome:HGNC:39961 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
USP12P2, Official Symbol USP12P2provided by HGNC Official Full Name USP12 pseudogene 2provided by HGNC Primary source HGNC:HGNC:54575 See related AllianceGenome:HGNC:54575 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
USP12PY, Official Symbol USP12PYprovided by HGNC Official Full Name USP12 pseudogene Y-linkedprovided by HGNC Primary source HGNC:HGNC:23195 See related AllianceGenome:HGNC:23195 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USP12P3
USP13, Official Symbol USP13provided by HGNC Official Full Name ubiquitin specific peptidase 13provided by HGNC Primary source HGNC:HGNC:12611 See related Ensembl:ENSG00000058056 MIM:603591; AllianceGenome:HGNC:12611 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ISOT3; IsoT-3 Summary Enables several functions, including BAT3 complex binding activity; chaperone binding activity; and cysteine-type peptidase activity. Involved in several processes, including maintenance of unfolded protein involved in ERAD pathway; regulation of cellular catabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in heart (RPKM 16.6), adrenal (RPKM 7.5) and 21 other tissues See more Orthologs mouse all
USP14, Official Symbol USP14provided by HGNC Official Full Name ubiquitin specific peptidase 14provided by HGNC Primary source HGNC:HGNC:12612 See related Ensembl:ENSG00000101557 MIM:607274; AllianceGenome:HGNC:12612 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TGT; Ubp6 Summary This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 16.7), prostate (RPKM 15.4) and 25 other tissues See more Orthologs mouse all
USP15, Official Symbol USP15provided by HGNC Official Full Name ubiquitin specific peptidase 15provided by HGNC Primary source HGNC:HGNC:12613 See related Ensembl:ENSG00000135655 MIM:604731; AllianceGenome:HGNC:12613 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNPH4; UNPH-2 Summary This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in bone marrow (RPKM 16.1), appendix (RPKM 8.0) and 24 other tissues See more Orthologs mouse all
USP16, Official Symbol USP16provided by HGNC Official Full Name ubiquitin specific peptidase 16provided by HGNC Primary source HGNC:HGNC:12614 See related Ensembl:ENSG00000156256 MIM:604735; AllianceGenome:HGNC:12614 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBPM; UBP-M Summary This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 20.1), testis (RPKM 16.3) and 25 other tissues See more Orthologs mouse all
USP17L1, Official Symbol USP17L1provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 1provided by HGNC Primary source HGNC:HGNC:37182 See related Ensembl:ENSG00000230549 AllianceGenome:HGNC:37182 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USP17L1P Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L10, Official Symbol USP17L10provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 10provided by HGNC Primary source HGNC:HGNC:44438 See related Ensembl:ENSG00000231396 AllianceGenome:HGNC:44438 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L11, Official Symbol USP17L11provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 11provided by HGNC Primary source HGNC:HGNC:44439 See related Ensembl:ENSG00000233136 AllianceGenome:HGNC:44439 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L12, Official Symbol USP17L12provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 12provided by HGNC Primary source HGNC:HGNC:44440 See related Ensembl:ENSG00000227551 AllianceGenome:HGNC:44440 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L13, Official Symbol USP17L13provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 13provided by HGNC Primary source HGNC:HGNC:44441 See related Ensembl:ENSG00000232399 AllianceGenome:HGNC:44441 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L14P, Official Symbol USP17L14Pprovided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 14, pseudogeneprovided by HGNC Primary source HGNC:HGNC:44442 See related Ensembl:ENSG00000249482 AllianceGenome:HGNC:44442 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
USP17L15, Official Symbol USP17L15provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 15provided by HGNC Primary source HGNC:HGNC:44443 See related Ensembl:ENSG00000223569 AllianceGenome:HGNC:44443 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
USP17L16P, Official Symbol USP17L16Pprovided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 16, pseudogeneprovided by HGNC Primary source HGNC:HGNC:44444 See related AllianceGenome:HGNC:44444 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
USP17L17, Official Symbol USP17L17provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 17provided by HGNC Primary source HGNC:HGNC:44445 See related Ensembl:ENSG00000249104 AllianceGenome:HGNC:44445 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L18, Official Symbol USP17L18provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 18provided by HGNC Primary source HGNC:HGNC:44446 See related Ensembl:ENSG00000250844 AllianceGenome:HGNC:44446 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L19, Official Symbol USP17L19provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 19provided by HGNC Primary source HGNC:HGNC:44447 See related Ensembl:ENSG00000248920 AllianceGenome:HGNC:44447 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L2, Official Symbol USP17L2provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 2provided by HGNC Primary source HGNC:HGNC:34434 See related Ensembl:ENSG00000223443 MIM:610186; AllianceGenome:HGNC:34434 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUB3; DUB-3; USP17 Summary DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008] Annotation information Annotation category: suggests misassembly Orthologs all
USP17L20, Official Symbol USP17L20provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 20provided by HGNC Primary source HGNC:HGNC:44448 See related Ensembl:ENSG00000250745 AllianceGenome:HGNC:44448 Gene type protein coding RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L21, Official Symbol USP17L21provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 21provided by HGNC Primary source HGNC:HGNC:44449 See related Ensembl:ENSG00000249811 AllianceGenome:HGNC:44449 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L22, Official Symbol USP17L22provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 22provided by HGNC Primary source HGNC:HGNC:44450 See related Ensembl:ENSG00000248933 AllianceGenome:HGNC:44450 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L24, Official Symbol USP17L24provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 24provided by HGNC Primary source HGNC:HGNC:44453 See related Ensembl:ENSG00000232264 AllianceGenome:HGNC:44453 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USP17L25; USP17L26; USP17L27; USP17L28; USP17L29; USP17L30 Summary Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L25, Official Symbol USP17L25provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 25provided by HGNC Primary source HGNC:HGNC:44452 See related Ensembl:ENSG00000230430 AllianceGenome:HGNC:44452 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L26, Official Symbol USP17L26provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 26provided by HGNC Primary source HGNC:HGNC:44454 See related Ensembl:ENSG00000229579 AllianceGenome:HGNC:44454 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L27, Official Symbol USP17L27provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 27provided by HGNC Primary source HGNC:HGNC:44455 See related Ensembl:ENSG00000235780 AllianceGenome:HGNC:44455 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L28, Official Symbol USP17L28provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 28provided by HGNC Primary source HGNC:HGNC:44456 See related Ensembl:ENSG00000231051 AllianceGenome:HGNC:44456 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L29, Official Symbol USP17L29provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 29provided by HGNC Primary source HGNC:HGNC:44457 See related Ensembl:ENSG00000231637 AllianceGenome:HGNC:44457 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L3, Official Symbol USP17L3provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 3provided by HGNC Primary source HGNC:HGNC:37175 See related Ensembl:ENSG00000225327 AllianceGenome:HGNC:37175 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USP17B; USP17F Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: This gene contains an intact open reading frame; however, it is classified as a pseudogene because no transcripts available as of August 2009 are thought to originate from this location, suggesting that this gene does not have a functional promoter. [26 Aug 2009]
USP17L30, Official Symbol USP17L30provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 30provided by HGNC Primary source HGNC:HGNC:44458 See related Ensembl:ENSG00000228856 AllianceGenome:HGNC:44458 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L4, Official Symbol USP17L4provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 4provided by HGNC Primary source HGNC:HGNC:37176 See related Ensembl:ENSG00000236125 AllianceGenome:HGNC:37176 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: This gene contains an intact open reading frame; however, it is classified as a pseudogene because no transcripts available as of August 2009 are thought to originate from this location, suggesting that this gene does not have a functional promoter. [26 Aug 2009]
USP17L5, Official Symbol USP17L5provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 5provided by HGNC Primary source HGNC:HGNC:37177 See related Ensembl:ENSG00000227140 AllianceGenome:HGNC:37177 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L6P, Official Symbol USP17L6Pprovided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 6, pseudogeneprovided by HGNC Primary source HGNC:HGNC:37179 See related Ensembl:ENSG00000205946 AllianceGenome:HGNC:37179 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUB4; vDUB4; USP17L6 Summary Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L7, Official Symbol USP17L7provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 7provided by HGNC Primary source HGNC:HGNC:37180 See related Ensembl:ENSG00000226430 AllianceGenome:HGNC:37180 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
USP17L8, Official Symbol USP17L8provided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 8provided by HGNC Primary source HGNC:HGNC:37181 See related Ensembl:ENSG00000237038 AllianceGenome:HGNC:37181 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USP17L10 Summary Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: This gene contains an intact open reading frame; however, it is classified as a pseudogene because no transcripts available as of August 2009 are thought to originate from this location, suggesting that this gene does not have a functional promoter. [26 Aug 2009] Orthologs all
USP17L9P, Official Symbol USP17L9Pprovided by HGNC Official Full Name ubiquitin specific peptidase 17 like family member 9, pseudogeneprovided by HGNC Primary source HGNC:HGNC:12615 See related Ensembl:ENSG00000251694 MIM:607011; AllianceGenome:HGNC:12615 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RS447; USP17; USP17A; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M
USP18, Official Symbol USP18provided by HGNC Official Full Name ubiquitin specific peptidase 18provided by HGNC Primary source HGNC:HGNC:12616 See related Ensembl:ENSG00000184979 MIM:607057; AllianceGenome:HGNC:12616 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ISG43; UBP43; PTORCH2 Summary The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in fat (RPKM 6.5), spleen (RPKM 6.3) and 25 other tissues See more Orthologs mouse all
USP19, Official Symbol USP19provided by HGNC Official Full Name ubiquitin specific peptidase 19provided by HGNC Primary source HGNC:HGNC:12617 See related Ensembl:ENSG00000172046 MIM:614471; AllianceGenome:HGNC:12617 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZMYND9 Summary Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017] Expression Ubiquitous expression in testis (RPKM 12.9), thyroid (RPKM 11.3) and 25 other tissues See more Orthologs mouse all