psui3905/ncbi_genes_summary huggingface dataset:
KLHL40, Official Symbol KLHL40provided by HGNC Official Full Name kelch like family member 40provided by HGNC Primary source HGNC:HGNC:30372 See related Ensembl:ENSG00000157119 MIM:615340; AllianceGenome:HGNC:30372 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEM8; SRYP; SYRP; KBTBD5 Summary This gene encodes a protein containing a BACK domain, a BTB/POZ domain, and 5 Kelch repeats, however, its exact function is not known. The gene and the multi-domain protein structure are conserved across different taxa, including primates, rodents, chicken and zebrafish. [provided by RefSeq, Dec 2012] Expression Biased expression in prostate (RPKM 4.0), esophagus (RPKM 2.3) and 2 other tissues See more Orthologs mouse all
KLHL41, Official Symbol KLHL41provided by HGNC Official Full Name kelch like family member 41provided by HGNC Primary source HGNC:HGNC:16905 See related Ensembl:ENSG00000239474 MIM:607701; AllianceGenome:HGNC:16905 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Krp1; KBTBD10; SARCOSIN Summary This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015] Expression Biased expression in prostate (RPKM 65.0), esophagus (RPKM 43.9) and 2 other tissues See more Orthologs mouse all
KLHL42, Official Symbol KLHL42provided by HGNC Official Full Name kelch like family member 42provided by HGNC Primary source HGNC:HGNC:29252 See related Ensembl:ENSG00000087448 MIM:618919; AllianceGenome:HGNC:29252 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Ctb9; KLHDC5 Summary Contributes to ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 7.6), endometrium (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
KLHL5, Official Symbol KLHL5provided by HGNC Official Full Name kelch like family member 5provided by HGNC Primary source HGNC:HGNC:6356 See related Ensembl:ENSG00000109790 MIM:608064; AllianceGenome:HGNC:6356 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable actin binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 8.4), urinary bladder (RPKM 6.6) and 24 other tissues See more Orthologs mouse all
KLHL6, Official Symbol KLHL6provided by HGNC Official Full Name kelch like family member 6provided by HGNC Primary source HGNC:HGNC:18653 See related Ensembl:ENSG00000172578 MIM:614214; AllianceGenome:HGNC:18653 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017] Expression Biased expression in lymph node (RPKM 24.5), appendix (RPKM 11.9) and 10 other tissues See more Orthologs mouse all
KLHL6-AS1, Official Symbol KLHL6-AS1provided by HGNC Official Full Name KLHL6 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40850 See related Ensembl:ENSG00000242522 AllianceGenome:HGNC:40850 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
KLHL7, Official Symbol KLHL7provided by HGNC Official Full Name kelch like family member 7provided by HGNC Primary source HGNC:HGNC:15646 See related Ensembl:ENSG00000122550 MIM:611119; AllianceGenome:HGNC:15646 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CISS3; KLHL6; SBBI26; PERCHING Summary This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010] Expression Broad expression in heart (RPKM 18.6), testis (RPKM 12.2) and 24 other tissues See more Orthologs mouse all
KLHL8, Official Symbol KLHL8provided by HGNC Official Full Name kelch like family member 8provided by HGNC Primary source HGNC:HGNC:18644 See related Ensembl:ENSG00000145332 MIM:611967; AllianceGenome:HGNC:18644 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 11.3), kidney (RPKM 6.2) and 25 other tissues See more Orthologs mouse all
KLHL9, Official Symbol KLHL9provided by HGNC Official Full Name kelch like family member 9provided by HGNC Primary source HGNC:HGNC:18732 See related Ensembl:ENSG00000198642 MIM:611201; AllianceGenome:HGNC:18732 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016] Orthologs mouse all
KLK1, Official Symbol KLK1provided by HGNC Official Full Name kallikrein 1provided by HGNC Primary source HGNC:HGNC:6357 See related Ensembl:ENSG00000167748 MIM:147910; AllianceGenome:HGNC:6357 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hK1; KLKR; Klk6 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008] Expression Biased expression in salivary gland (RPKM 569.2) and pancreas (RPKM 508.7) See more Orthologs mouse all
KLK10, Official Symbol KLK10provided by HGNC Official Full Name kallikrein related peptidase 10provided by HGNC Primary source HGNC:HGNC:6358 See related Ensembl:ENSG00000129451 MIM:602673; AllianceGenome:HGNC:6358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NES1; PRSSL1 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 28.7), skin (RPKM 8.9) and 3 other tissues See more Orthologs mouse all
KLK11, Official Symbol KLK11provided by HGNC Official Full Name kallikrein related peptidase 11provided by HGNC Primary source HGNC:HGNC:6359 See related Ensembl:ENSG00000167757 MIM:604434; AllianceGenome:HGNC:6359 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLSP; PRSS20 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016] Expression Biased expression in esophagus (RPKM 58.7), skin (RPKM 44.2) and 7 other tissues See more Orthologs mouse all
KLK12, Official Symbol KLK12provided by HGNC Official Full Name kallikrein related peptidase 12provided by HGNC Primary source HGNC:HGNC:6360 See related Ensembl:ENSG00000186474 MIM:605539; AllianceGenome:HGNC:6360 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLKL5; KLK-L5 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 4.6), salivary gland (RPKM 1.0) and 4 other tissues See more Orthologs mouse all
KLK13, Official Symbol KLK13provided by HGNC Official Full Name kallikrein related peptidase 13provided by HGNC Primary source HGNC:HGNC:6361 See related Ensembl:ENSG00000167759 MIM:605505; AllianceGenome:HGNC:6361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLKL4; KLK-L4 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017] Expression Restricted expression toward esophagus (RPKM 227.0) See more Orthologs mouse all
KLK14, Official Symbol KLK14provided by HGNC Official Full Name kallikrein related peptidase 14provided by HGNC Primary source HGNC:HGNC:6362 See related Ensembl:ENSG00000129437 MIM:606135; AllianceGenome:HGNC:6362 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLK-L6 Summary This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] Expression Biased expression in skin (RPKM 2.1), testis (RPKM 0.2) and 6 other tissues See more Orthologs mouse all
KLK15, Official Symbol KLK15provided by HGNC Official Full Name kallikrein related peptidase 15provided by HGNC Primary source HGNC:HGNC:20453 See related Ensembl:ENSG00000174562 MIM:610601; AllianceGenome:HGNC:20453 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACO; HSRNASPH Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in colon (RPKM 1.2), testis (RPKM 1.0) and 5 other tissues See more Orthologs mouse all
KLK2, Official Symbol KLK2provided by HGNC Official Full Name kallikrein related peptidase 2provided by HGNC Primary source HGNC:HGNC:6363 See related Ensembl:ENSG00000167751 MIM:147960; AllianceGenome:HGNC:6363 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hK2; hGK-1; KLK2A2 Summary This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012] Expression Restricted expression toward prostate (RPKM 1047.4) See more Orthologs all
KLK3, Official Symbol KLK3provided by HGNC Official Full Name kallikrein related peptidase 3provided by HGNC Primary source HGNC:HGNC:6364 See related Ensembl:ENSG00000142515 MIM:176820; AllianceGenome:HGNC:6364 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APS; PSA; hK3; KLK2A1 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019] Expression Restricted expression toward prostate (RPKM 4286.7) See more Orthologs all
KLK4, Official Symbol KLK4provided by HGNC Official Full Name kallikrein related peptidase 4provided by HGNC Primary source HGNC:HGNC:6365 See related Ensembl:ENSG00000167749 MIM:603767; AllianceGenome:HGNC:6365 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014] Expression Restricted expression toward prostate (RPKM 123.8) See more Orthologs mouse all
KLK5, Official Symbol KLK5provided by HGNC Official Full Name kallikrein related peptidase 5provided by HGNC Primary source HGNC:HGNC:6366 See related Ensembl:ENSG00000167754 MIM:605643; AllianceGenome:HGNC:6366 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCTE; KLKL2; KLK-L2 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue See more Orthologs mouse all
KLK6, Official Symbol KLK6provided by HGNC Official Full Name kallikrein related peptidase 6provided by HGNC Primary source HGNC:HGNC:6367 See related Ensembl:ENSG00000167755 MIM:602652; AllianceGenome:HGNC:6367 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hK6; Bssp; Klk7; SP59; PRSS9; PRSS18 Summary This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] Expression Biased expression in esophagus (RPKM 23.8), brain (RPKM 23.7) and 4 other tissues See more Orthologs all
KLK7, Official Symbol KLK7provided by HGNC Official Full Name kallikrein related peptidase 7provided by HGNC Primary source HGNC:HGNC:6368 See related Ensembl:ENSG00000169035 MIM:604438; AllianceGenome:HGNC:6368 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hK7; SCCE; PRSS6 Summary This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011] Expression Biased expression in skin (RPKM 68.1) and esophagus (RPKM 25.3) See more Orthologs mouse all
KLK8, Official Symbol KLK8provided by HGNC Official Full Name kallikrein related peptidase 8provided by HGNC Primary source HGNC:HGNC:6369 See related Ensembl:ENSG00000129455 MIM:605644; AllianceGenome:HGNC:6369 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NP; HNP; NRPN; PRSS19; TADG14 Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] Annotation information Note: The KLK9 gene is immediately upstream of the KLK8 gene. There are a few transcripts (DQ267419, DQ267420, AY566267, and BC040887) that span the gap between these two genes and which suggest the presence of a bicistronic transcript. However, there is no published support for that, so they will continue to be represented as separate genes. [13 Feb 2013] Expression Biased expression in skin (RPKM 32.0) and esophagus (RPKM 29.8) See more Orthologs mouse all
KLK9, Official Symbol KLK9provided by HGNC Official Full Name kallikrein related peptidase 9provided by HGNC Primary source HGNC:HGNC:6370 See related Ensembl:ENSG00000213022 MIM:605504; AllianceGenome:HGNC:6370 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLKL3; KLK-L3 Summary The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010] Annotation information Note: The KLK9 gene is immediately upstream of the KLK8 gene. There are a few transcripts (DQ267419, DQ267420, AY566267, and BC040887) that span the gap between these two genes and which suggest the presence of a bicistronic transcript. However, there is no published support for that, so they will continue to be represented as separate genes. [13 Feb 2013] Expression Restricted expression toward skin (RPKM 5.2) See more Orthologs mouse all
KLKB1, Official Symbol KLKB1provided by HGNC Official Full Name kallikrein B1provided by HGNC Primary source HGNC:HGNC:6371 See related Ensembl:ENSG00000164344 MIM:229000; AllianceGenome:HGNC:6371 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKK; PPK; KLK3; PKKD Summary This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Biased expression in liver (RPKM 44.5) and kidney (RPKM 1.2) See more Orthologs mouse all
KLLN, Official Symbol KLLNprovided by HGNC Official Full Name killin, p53 regulated DNA replication inhibitorprovided by HGNC Primary source HGNC:HGNC:37212 See related Ensembl:ENSG00000227268 MIM:612105; AllianceGenome:HGNC:37212 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CWS4; KILLIN Summary The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012] Orthologs mouse all
KLRB1, Official Symbol KLRB1provided by HGNC Official Full Name killer cell lectin like receptor B1provided by HGNC Primary source HGNC:HGNC:6373 See related Ensembl:ENSG00000111796 MIM:602890; AllianceGenome:HGNC:6373 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A Summary Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 31.5), spleen (RPKM 28.1) and 14 other tissues See more Orthologs mouse all
KLRC1, Official Symbol KLRC1provided by HGNC Official Full Name killer cell lectin like receptor C1provided by HGNC Primary source HGNC:HGNC:6374 See related Ensembl:ENSG00000134545 MIM:161555; AllianceGenome:HGNC:6374 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKG2; NKG2A; CD159A Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015] Expression Broad expression in spleen (RPKM 1.5), endometrium (RPKM 1.3) and 21 other tissues See more Orthologs all
KLRC2, Official Symbol KLRC2provided by HGNC Official Full Name killer cell lectin like receptor C2provided by HGNC Primary source HGNC:HGNC:6375 See related Ensembl:ENSG00000205809 MIM:602891; AllianceGenome:HGNC:6375 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKG2C; CD159c; NKG2-C Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 6.7), spleen (RPKM 3.4) and 9 other tissues See more Orthologs all
KLRC3, Official Symbol KLRC3provided by HGNC Official Full Name killer cell lectin like receptor C3provided by HGNC Primary source HGNC:HGNC:6376 See related Ensembl:ENSG00000205810 MIM:602892; AllianceGenome:HGNC:6376 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKG2E; NKG2-E Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 5.1), spleen (RPKM 3.6) and 8 other tissues See more
KLRC4, Official Symbol KLRC4provided by HGNC Official Full Name killer cell lectin like receptor C4provided by HGNC Primary source HGNC:HGNC:6377 See related Ensembl:ENSG00000183542 MIM:602893; AllianceGenome:HGNC:6377 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKG2F; NKG2-F Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010] Expression Broad expression in spleen (RPKM 6.6), lymph node (RPKM 3.0) and 17 other tissues See more Orthologs all
KLRD1, Official Symbol KLRD1provided by HGNC Official Full Name killer cell lectin like receptor D1provided by HGNC Primary source HGNC:HGNC:6378 See related Ensembl:ENSG00000134539 MIM:602894; AllianceGenome:HGNC:6378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD94 Summary Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017] Expression Broad expression in spleen (RPKM 3.3), lung (RPKM 0.9) and 15 other tissues See more Orthologs all
KLRF1, Official Symbol KLRF1provided by HGNC Official Full Name killer cell lectin like receptor F1provided by HGNC Primary source HGNC:HGNC:13342 See related Ensembl:ENSG00000150045 MIM:605029; AllianceGenome:HGNC:13342 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKp80; CLEC5C Summary KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009] Expression Biased expression in spleen (RPKM 7.2), bone marrow (RPKM 3.9) and 10 other tissues See more Orthologs all
KLRF2, Official Symbol KLRF2provided by HGNC Official Full Name killer cell lectin like receptor F2provided by HGNC Primary source HGNC:HGNC:37646 See related Ensembl:ENSG00000256797 MIM:618814; AllianceGenome:HGNC:37646 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKp65 Summary Enables protein homodimerization activity. Predicted to be involved in natural killer cell degranulation and positive regulation of cytokine production. Predicted to act upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 1.7), lymph node (RPKM 0.2) and 3 other tissues See more Orthologs all
KLRG1, Official Symbol KLRG1provided by HGNC Official Full Name killer cell lectin like receptor G1provided by HGNC Primary source HGNC:HGNC:6380 See related Ensembl:ENSG00000139187 MIM:604874; AllianceGenome:HGNC:6380 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016] Expression Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.1) and 23 other tissues See more Orthologs mouse all
KLRG2, Official Symbol KLRG2provided by HGNC Official Full Name killer cell lectin like receptor G2provided by HGNC Primary source HGNC:HGNC:24778 See related Ensembl:ENSG00000188883 AllianceGenome:HGNC:24778 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLEC15B Summary Predicted to enable carbohydrate binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 1.5), thyroid (RPKM 1.0) and 8 other tissues See more Orthologs mouse all
KLRK1, Official Symbol KLRK1provided by HGNC Official Full Name killer cell lectin like receptor K1provided by HGNC Primary source HGNC:HGNC:18788 See related Ensembl:ENSG00000213809 MIM:611817; AllianceGenome:HGNC:18788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLR; CD314; NKG2D; NKG2-D; D12S2489E Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010] Expression Broad expression in spleen (RPKM 28.6), lymph node (RPKM 22.6) and 16 other tissues See more Orthologs mouse all
KLRK1-AS1, Official Symbol KLRK1-AS1provided by HGNC Official Full Name KLRK1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54868 See related Ensembl:ENSG00000245648 AllianceGenome:HGNC:54868 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TP53LC04 Expression Broad expression in spleen (RPKM 1.3), lymph node (RPKM 1.0) and 20 other tissues See more
KMO, Official Symbol KMOprovided by HGNC Official Full Name kynurenine 3-monooxygenaseprovided by HGNC Primary source HGNC:HGNC:6381 See related Ensembl:ENSG00000117009 MIM:603538; AllianceGenome:HGNC:6381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ317G22.1 Summary This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011] Expression Broad expression in liver (RPKM 11.5), kidney (RPKM 9.8) and 20 other tissues See more Orthologs mouse all
KMT2A, Official Symbol KMT2Aprovided by HGNC Official Full Name lysine methyltransferase 2Aprovided by HGNC Primary source HGNC:HGNC:7132 See related Ensembl:ENSG00000118058 MIM:159555; AllianceGenome:HGNC:7132 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRX; MLL; ALL1; GAS7; HTRX; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS Summary This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] Expression Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
KMT2B, Official Symbol KMT2Bprovided by HGNC Official Full Name lysine methyltransferase 2Bprovided by HGNC Primary source HGNC:HGNC:15840 See related Ensembl:ENSG00000272333 MIM:606834; AllianceGenome:HGNC:15840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRX2; MLL2; MLL4; TRX2; WBP7; DYT28; MLL1B; MRD68; WBP-7; CXXC10 Summary This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 15.2), spleen (RPKM 7.9) and 25 other tissues See more Orthologs mouse all
KMT2C, Official Symbol KMT2Cprovided by HGNC Official Full Name lysine methyltransferase 2Cprovided by HGNC Primary source HGNC:HGNC:13726 See related Ensembl:ENSG00000055609 MIM:606833; AllianceGenome:HGNC:13726 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HALR; MLL3; KLEFS2 Summary This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 8.7), bone marrow (RPKM 8.5) and 25 other tissues See more Orthologs mouse all