psui3905/ncbi_genes_summary huggingface dataset:
HS6ST2-AS1, Official Symbol HS6ST2-AS1provided by HGNC Official Full Name HS6ST2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40870 See related Ensembl:ENSG00000235849 AllianceGenome:HGNC:40870 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
HS6ST3, Official Symbol HS6ST3provided by HGNC Official Full Name heparan sulfate 6-O-sulfotransferase 3provided by HGNC Primary source HGNC:HGNC:19134 See related Ensembl:ENSG00000185352 MIM:609401; AllianceGenome:HGNC:19134 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HS6ST-3 Summary Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008] Expression Biased expression in brain (RPKM 5.5), urinary bladder (RPKM 1.6) and 3 other tissues See more Orthologs mouse all
HSBP1, Official Symbol HSBP1provided by HGNC Official Full Name heat shock factor binding protein 1provided by HGNC Primary source HGNC:HGNC:5203 See related Ensembl:ENSG00000230989 MIM:604553; AllianceGenome:HGNC:5203 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPC-A-13 Summary The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 51.9), thyroid (RPKM 45.3) and 25 other tissues See more Orthologs mouse all
HSBP1L1, Official Symbol HSBP1L1provided by HGNC Official Full Name heat shock factor binding protein 1 like 1provided by HGNC Primary source HGNC:HGNC:37243 See related Ensembl:ENSG00000226742 AllianceGenome:HGNC:37243 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription corepressor activity. Predicted to be involved in cellular heat acclimation. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 10.7), kidney (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
HSCB, Official Symbol HSCBprovided by HGNC Official Full Name HscB mitochondrial iron-sulfur cluster cochaperoneprovided by HGNC Primary source HGNC:HGNC:28913 See related Ensembl:ENSG00000100209 MIM:608142; AllianceGenome:HGNC:28913 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JAC1; HSC20; SIDBA5; DNAJC20 Summary This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in ovary (RPKM 4.7), prostate (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
HSD11B1, Official Symbol HSD11B1provided by HGNC Official Full Name hydroxysteroid 11-beta dehydrogenase 1provided by HGNC Primary source HGNC:HGNC:5208 See related Ensembl:ENSG00000117594 MIM:600713; AllianceGenome:HGNC:5208 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1 Summary The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011] Expression Biased expression in liver (RPKM 186.4), placenta (RPKM 27.2) and 1 other tissue See more Orthologs mouse all
HSD11B1-AS1, Official Symbol HSD11B1-AS1provided by HGNC Official Full Name HSD11B1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54053 See related Ensembl:ENSG00000227591 AllianceGenome:HGNC:54053 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in fat (RPKM 33.1) and kidney (RPKM 1.3) See more
HSD11B1L, Official Symbol HSD11B1Lprovided by HGNC Official Full Name hydroxysteroid 11-beta dehydrogenase 1 likeprovided by HGNC Primary source HGNC:HGNC:30419 See related Ensembl:ENSG00000167733 AllianceGenome:HGNC:30419 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSD3; HSD1L; 11-DH3; SCDR10; SCDR10B; SDR26C2; 11-beta-HSD3 Summary This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012] Expression Broad expression in brain (RPKM 7.1), testis (RPKM 2.5) and 23 other tissues See more Orthologs all
HSD11B2, Official Symbol HSD11B2provided by HGNC Official Full Name hydroxysteroid 11-beta dehydrogenase 2provided by HGNC Primary source HGNC:HGNC:5209 See related Ensembl:ENSG00000176387 MIM:614232; AllianceGenome:HGNC:5209 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AME; AME1; HSD2; HSD11K; SDR9C3 Summary There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010] Expression Biased expression in kidney (RPKM 155.7), colon (RPKM 97.2) and 6 other tissues See more Orthologs mouse all
HSD17B1, Official Symbol HSD17B1provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 1provided by HGNC Primary source HGNC:HGNC:5210 See related Ensembl:ENSG00000108786 MIM:109684; AllianceGenome:HGNC:5210 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E2DH; HSD17; EDHB17; EDH17B2; SDR28C1; 17-beta-HSD; 20-alpha-HSD Summary This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Biased expression in placenta (RPKM 41.1), fat (RPKM 4.7) and 11 other tissues See more Orthologs mouse all
HSD17B1-AS1, Official Symbol HSD17B1-AS1provided by HGNC Official Full Name HSD17B1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55314 See related Ensembl:ENSG00000266962 AllianceGenome:HGNC:55314 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HSD17B10, Official Symbol HSD17B10provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 10provided by HGNC Primary source HGNC:HGNC:4800 See related Ensembl:ENSG00000072506 MIM:300256; AllianceGenome:HGNC:4800 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; HSD10MD; 17b-HSD10; DUPXp11.22 Summary This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014] Expression Ubiquitous expression in liver (RPKM 63.6), kidney (RPKM 48.2) and 25 other tissues See more Orthologs mouse all
HSD17B11, Official Symbol HSD17B11provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 11provided by HGNC Primary source HGNC:HGNC:22960 See related Ensembl:ENSG00000198189 MIM:612831; AllianceGenome:HGNC:22960 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI Summary Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009] Expression Broad expression in small intestine (RPKM 142.3), duodenum (RPKM 102.8) and 22 other tissues See more Orthologs mouse all
HSD17B12, Official Symbol HSD17B12provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 12provided by HGNC Primary source HGNC:HGNC:18646 See related Ensembl:ENSG00000149084 MIM:609574; AllianceGenome:HGNC:18646 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAR; SDR12C1 Summary This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in brain (RPKM 34.2), kidney (RPKM 34.0) and 25 other tissues See more Orthologs mouse all
HSD17B13, Official Symbol HSD17B13provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 13provided by HGNC Primary source HGNC:HGNC:18685 See related Ensembl:ENSG00000170509 MIM:612127; AllianceGenome:HGNC:18685 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLDP; SCDR9; NIIL497; SDR16C3; HMFN0376 Summary Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Acts upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 126.6) and fat (RPKM 7.3) See more Orthologs mouse all
HSD17B14, Official Symbol HSD17B14provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 14provided by HGNC Primary source HGNC:HGNC:23238 See related Ensembl:ENSG00000087076 MIM:612832; AllianceGenome:HGNC:23238 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DHRS10; SDR47C1; retSDR3 Summary 17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009] Expression Broad expression in kidney (RPKM 32.8), ovary (RPKM 12.9) and 14 other tissues See more Orthologs mouse all
HSD17B2, Official Symbol HSD17B2provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 2provided by HGNC Primary source HGNC:HGNC:5211 See related Ensembl:ENSG00000086696 MIM:109685; AllianceGenome:HGNC:5211 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSD17; SDR9C2; EDH17B2 Summary Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 177.2), placenta (RPKM 169.8) and 6 other tissues See more Orthologs mouse all
HSD17B3, Official Symbol HSD17B3provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 3provided by HGNC Primary source HGNC:HGNC:5212 See related Ensembl:ENSG00000130948 MIM:605573; AllianceGenome:HGNC:5212 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDH17B3; SDR12C2 Summary This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 7.7), small intestine (RPKM 0.7) and 4 other tissues See more Orthologs mouse all
HSD17B3-AS1, Official Symbol HSD17B3-AS1provided by HGNC Official Full Name HSD17B3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53136 See related Ensembl:ENSG00000232283 AllianceGenome:HGNC:53136 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
HSD17B4, Official Symbol HSD17B4provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 4provided by HGNC Primary source HGNC:HGNC:5213 See related Ensembl:ENSG00000133835 MIM:601860; AllianceGenome:HGNC:5213 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBP; MFE-2; MFP-2; MPF-2; PRLTS1; SDR8C1 Summary The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] Expression Ubiquitous expression in liver (RPKM 94.4), thyroid (RPKM 88.0) and 25 other tissues See more Orthologs mouse all
HSD17B6, Official Symbol HSD17B6provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 6provided by HGNC Primary source HGNC:HGNC:23316 See related Ensembl:ENSG00000025423 MIM:606623; AllianceGenome:HGNC:23316 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSE; RODH; SDR9C6 Summary The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013] Expression Biased expression in liver (RPKM 415.0), lung (RPKM 33.0) and 2 other tissues See more Orthologs mouse all
HSD17B7, Official Symbol HSD17B7provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 7provided by HGNC Primary source HGNC:HGNC:5215 See related Ensembl:ENSG00000132196 MIM:606756; AllianceGenome:HGNC:5215 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAP; SDR37C1 Summary HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010] Expression Ubiquitous expression in adrenal (RPKM 6.0), lymph node (RPKM 4.5) and 25 other tissues See more Orthologs mouse all
HSD17B8, Official Symbol HSD17B8provided by HGNC Official Full Name hydroxysteroid 17-beta dehydrogenase 8provided by HGNC Primary source HGNC:HGNC:3554 See related Ensembl:ENSG00000204228 MIM:601417; AllianceGenome:HGNC:3554 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9 Summary In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 17.4), kidney (RPKM 16.9) and 25 other tissues See more Orthologs mouse all
HSD3B1, Official Symbol HSD3B1provided by HGNC Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1provided by HGNC Primary source HGNC:HGNC:5217 See related Ensembl:ENSG00000203857 MIM:109715; AllianceGenome:HGNC:5217 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSD3B; HSDB3; HSDB3A; SDR11E1; 3BETAHSD Summary The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016] Expression Restricted expression toward placenta (RPKM 60.6) See more Orthologs mouse all
HSD3B2, Official Symbol HSD3B2provided by HGNC Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2provided by HGNC Primary source HGNC:HGNC:5218 See related Ensembl:ENSG00000203859 MIM:613890; AllianceGenome:HGNC:5218 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSDB; HSD3B; SDR11E2 Summary The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] Expression Restricted expression toward adrenal (RPKM 1042.2) See more Orthologs all
HSD3B7, Official Symbol HSD3B7provided by HGNC Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7provided by HGNC Primary source HGNC:HGNC:18324 See related Ensembl:ENSG00000099377 MIM:607764; AllianceGenome:HGNC:18324 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBAS1; PFIC4; SDR11E3 Summary This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] Expression Ubiquitous expression in liver (RPKM 10.0), kidney (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
HSD3BP2, Official Symbol HSD3BP2provided by HGNC Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 2provided by HGNC Primary source HGNC:HGNC:5220 See related Ensembl:ENSG00000203858 AllianceGenome:HGNC:5220 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HSD3BP3, Official Symbol HSD3BP3provided by HGNC Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 3provided by HGNC Primary source HGNC:HGNC:5221 See related AllianceGenome:HGNC:5221 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HSD3BP4, Official Symbol HSD3BP4provided by HGNC Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4provided by HGNC Primary source HGNC:HGNC:5222 See related AllianceGenome:HGNC:5222 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HSDL1, Official Symbol HSDL1provided by HGNC Official Full Name hydroxysteroid dehydrogenase like 1provided by HGNC Primary source HGNC:HGNC:16475 See related Ensembl:ENSG00000103160 MIM:619067; AllianceGenome:HGNC:16475 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR12C3 Summary Predicted to enable oxidoreductase activity. Located in intermediate filament cytoskeleton and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 18.3), brain (RPKM 13.0) and 24 other tissues See more Orthologs mouse all
HSDL2, Official Symbol HSDL2provided by HGNC Official Full Name hydroxysteroid dehydrogenase like 2provided by HGNC Primary source HGNC:HGNC:18572 See related Ensembl:ENSG00000119471 AllianceGenome:HGNC:18572 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C9orf99; SDR13C1 Summary Predicted to enable oxidoreductase activity. Located in mitochondrion and peroxisome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 44.0), liver (RPKM 33.8) and 24 other tissues See more Orthologs mouse all
HSF1, Official Symbol HSF1provided by HGNC Official Full Name heat shock transcription factor 1provided by HGNC Primary source HGNC:HGNC:5224 See related Ensembl:ENSG00000185122 MIM:140580; AllianceGenome:HGNC:5224 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSTF1 Summary The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in testis (RPKM 49.6), heart (RPKM 24.2) and 25 other tissues See more Orthologs mouse all
HSF2, Official Symbol HSF2provided by HGNC Official Full Name heat shock transcription factor 2provided by HGNC Primary source HGNC:HGNC:5225 See related Ensembl:ENSG00000025156 MIM:140581; AllianceGenome:HGNC:5225 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSF 2; HSTF 2 Summary The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] Expression Broad expression in testis (RPKM 22.1), bone marrow (RPKM 8.8) and 23 other tissues See more Orthologs mouse all
HSF2BP, Official Symbol HSF2BPprovided by HGNC Official Full Name heat shock transcription factor 2 binding proteinprovided by HGNC Primary source HGNC:HGNC:5226 See related Ensembl:ENSG00000160207 MIM:604554; AllianceGenome:HGNC:5226 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POF19; MEILB2 Summary HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 2.8), brain (RPKM 0.5) and 6 other tissues See more Orthologs mouse all
HSF4, Official Symbol HSF4provided by HGNC Official Full Name heat shock transcription factor 4provided by HGNC Primary source HGNC:HGNC:5227 See related Ensembl:ENSG00000102878 MIM:602438; AllianceGenome:HGNC:5227 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTM; CTRCT5 Summary Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 12.6), skin (RPKM 8.5) and 24 other tissues See more Orthologs mouse all
HSF5, Official Symbol HSF5provided by HGNC Official Full Name heat shock transcription factor 5provided by HGNC Primary source HGNC:HGNC:26862 See related Ensembl:ENSG00000176160 AllianceGenome:HGNC:26862 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSF 5; HSTF 5 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 33.9) See more Orthologs mouse all
HSFX1, Official Symbol HSFX1provided by HGNC Official Full Name heat shock transcription factor family, X-linked 1provided by HGNC Primary source HGNC:HGNC:29603 See related Ensembl:ENSG00000171116 AllianceGenome:HGNC:29603 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LW-1 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 3.9), ovary (RPKM 1.9) and 22 other tissues See more Orthologs all
HSFX2, Official Symbol HSFX2provided by HGNC Official Full Name heat shock transcription factor family, X-linked 2provided by HGNC Primary source HGNC:HGNC:32701 See related Ensembl:ENSG00000268738 AllianceGenome:HGNC:32701 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 4.0), ovary (RPKM 1.8) and 22 other tissues See more Orthologs all
HSFX3, Official Symbol HSFX3provided by HGNC Official Full Name heat shock transcription factor family, X-linked member 3provided by HGNC Primary source HGNC:HGNC:52395 See related Ensembl:ENSG00000283697 AllianceGenome:HGNC:52395 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 12.8), adrenal (RPKM 9.1) and 23 other tissues See more Orthologs all
HSFX4, Official Symbol HSFX4provided by HGNC Official Full Name heat shock transcription factor family, X-linked member 4provided by HGNC Primary source HGNC:HGNC:52398 See related Ensembl:ENSG00000283463 AllianceGenome:HGNC:52398 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 16.2), adrenal (RPKM 10.0) and 24 other tissues See more Orthologs all
HSFY1, Official Symbol HSFY1provided by HGNC Official Full Name heat shock transcription factor Y-linked 1provided by HGNC Primary source HGNC:HGNC:18568 See related Ensembl:ENSG00000172468 MIM:400029; AllianceGenome:HGNC:18568 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSFY; HSF2L Summary This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 15.9) See more
HSFY2, Official Symbol HSFY2provided by HGNC Official Full Name heat shock transcription factor Y-linked 2provided by HGNC Primary source HGNC:HGNC:23950 See related Ensembl:ENSG00000169953 AllianceGenome:HGNC:23950 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSFY; HSF2L Summary This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 13.8) See more
HSFY3P, Official Symbol HSFY3Pprovided by HGNC Official Full Name heat shock transcription factor Y-linked 3, pseudogeneprovided by HGNC Primary source HGNC:HGNC:37119 See related Ensembl:ENSG00000227289 AllianceGenome:HGNC:37119 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSFYP2
HSFY5P, Official Symbol HSFY5Pprovided by HGNC Official Full Name heat shock transcription factor Y-linked 5, pseudogeneprovided by HGNC Primary source HGNC:HGNC:38789 See related Ensembl:ENSG00000232475 AllianceGenome:HGNC:38789 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HSFY7P, Official Symbol HSFY7Pprovided by HGNC Official Full Name heat shock transcription factor Y-linked 7, pseudogeneprovided by HGNC Primary source HGNC:HGNC:38791 See related Ensembl:ENSG00000228571 AllianceGenome:HGNC:38791 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HSFY8P, Official Symbol HSFY8Pprovided by HGNC Official Full Name heat shock transcription factor Y-linked 8, pseudogeneprovided by HGNC Primary source HGNC:HGNC:38792 See related Ensembl:ENSG00000233156 AllianceGenome:HGNC:38792 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HSH2D, Official Symbol HSH2Dprovided by HGNC Official Full Name hematopoietic SH2 domain containingprovided by HGNC Primary source HGNC:HGNC:24920 See related Ensembl:ENSG00000196684 MIM:608349; AllianceGenome:HGNC:24920 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALX; HSH2 Summary T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008] Expression Biased expression in bone marrow (RPKM 13.9), spleen (RPKM 9.5) and 11 other tissues See more Orthologs mouse all
HSP90AA1, Official Symbol HSP90AA1provided by HGNC Official Full Name heat shock protein 90 alpha family class A member 1provided by HGNC Primary source HGNC:HGNC:5253 See related Ensembl:ENSG00000080824 MIM:140571; AllianceGenome:HGNC:5253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p Summary The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in brain (RPKM 360.6), testis (RPKM 312.5) and 25 other tissues See more Orthologs mouse all
HSP90AA6P, Official Symbol HSP90AA6Pprovided by HGNC Official Full Name heat shock protein 90 alpha family class A member 6, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32536 See related Ensembl:ENSG00000181359 AllianceGenome:HGNC:32536 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSP90Af
HSP90AB1, Official Symbol HSP90AB1provided by HGNC Official Full Name heat shock protein 90 alpha family class B member 1provided by HGNC Primary source HGNC:HGNC:5258 See related Ensembl:ENSG00000096384 MIM:140572; AllianceGenome:HGNC:5258 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSP84; HSPC2; HSPCB; D6S182; HSP90B Summary This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more Orthologs mouse all
HSP90AB3P, Official Symbol HSP90AB3Pprovided by HGNC Official Full Name heat shock protein 90 alpha family class B member 3, pseudogeneprovided by HGNC Primary source HGNC:HGNC:5259 See related Ensembl:ENSG00000183199 AllianceGenome:HGNC:5259 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSPCP1; HSP90BC Summary Predicted to enable ATP binding activity; disordered domain specific binding activity; and unfolded protein binding activity. Predicted to be involved in cellular response to heat; protein folding; and protein stabilization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
HSP90AB4P, Official Symbol HSP90AB4Pprovided by HGNC Official Full Name heat shock protein 90 alpha family class B member 4, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32538 See related AllianceGenome:HGNC:32538 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSP90Bd Summary Predicted to enable ATP binding activity; disordered domain specific binding activity; and unfolded protein binding activity. Predicted to be involved in cellular response to heat; protein folding; and protein stabilization. Predicted to be part of protein-containing complex. Predicted to be active in cytosol; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
HSP90AB7P, Official Symbol HSP90AB7Pprovided by HGNC Official Full Name heat shock protein 90 alpha family class B member 7, pseudogeneprovided by HGNC Primary source HGNC:HGNC:44701 See related Ensembl:ENSG00000235838 AllianceGenome:HGNC:44701 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo