psui3905/ncbi_genes_summary huggingface dataset:
RTCA-AS1, Official Symbol RTCA-AS1provided by HGNC Official Full Name RTCA antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50573 See related AllianceGenome:HGNC:50573 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in kidney (RPKM 3.7), prostate (RPKM 2.0) and 24 other tissues See more
RTCB, Official Symbol RTCBprovided by HGNC Official Full Name RNA 2',3'-cyclic phosphate and 5'-OH ligaseprovided by HGNC Primary source HGNC:HGNC:26935 See related Ensembl:ENSG00000100220 MIM:613901; AllianceGenome:HGNC:26935 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAAP; HSPC117; C22orf28; DJ149A16.6 Summary Enables RNA ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 45.6), small intestine (RPKM 40.2) and 25 other tissues See more Orthologs mouse all
RTEL1, Official Symbol RTEL1provided by HGNC Official Full Name regulator of telomere elongation helicase 1provided by HGNC Primary source HGNC:HGNC:15888 See related Ensembl:ENSG00000258366 MIM:608833; AllianceGenome:HGNC:15888 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NHL; RTEL; DKCA4; DKCB5; PFBMFT3; C20orf41 Summary This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in testis (RPKM 6.4), appendix (RPKM 4.8) and 25 other tissues See more Orthologs mouse all
RTEL1-TNFRSF6B, Official Symbol RTEL1-TNFRSF6Bprovided by HGNC Official Full Name RTEL1-TNFRSF6B readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:44095 See related Ensembl:ENSG00000026036 AllianceGenome:HGNC:44095 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This locus represents naturally occurring read-through transcription between the neighboring RTEL1 (regulator of telomere elongation helicase 1) and TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in testis (RPKM 5.8), appendix (RPKM 5.5) and 25 other tissues See more
RTEL1P1, Official Symbol RTEL1P1provided by HGNC Official Full Name regulator of telomere elongation helicase 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44213 See related Ensembl:ENSG00000251441 AllianceGenome:HGNC:44213 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RTF1, Official Symbol RTF1provided by HGNC Official Full Name RTF1 homolog, Paf1/RNA polymerase II complex componentprovided by HGNC Primary source HGNC:HGNC:28996 See related Ensembl:ENSG00000137815 MIM:611633; AllianceGenome:HGNC:28996 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GTL7; KIAA0252 Summary This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010] Expression Ubiquitous expression in thyroid (RPKM 16.0), testis (RPKM 15.7) and 25 other tissues See more Orthologs mouse all
RTF2, Official Symbol RTF2provided by HGNC Official Full Name replication termination factor 2provided by HGNC Primary source HGNC:HGNC:15890 See related Ensembl:ENSG00000022277 AllianceGenome:HGNC:15890 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDAO5; RTFDC1; HSPC164; C20orf43; SHUJUN-3 Summary Enables DNA binding activity. Involved in cellular response to hydroxyurea and regulation of DNA stability. Located in replication fork. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 40.3), bone marrow (RPKM 39.0) and 25 other tissues See more Orthologs mouse all
RTKN, Official Symbol RTKNprovided by HGNC Official Full Name rhotekinprovided by HGNC Primary source HGNC:HGNC:10466 See related Ensembl:ENSG00000114993 MIM:602288; AllianceGenome:HGNC:10466 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RTKN-1 Summary This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 18.1), brain (RPKM 12.5) and 23 other tissues See more Orthologs mouse all
RTKN2, Official Symbol RTKN2provided by HGNC Official Full Name rhotekin 2provided by HGNC Primary source HGNC:HGNC:19364 See related Ensembl:ENSG00000182010 MIM:618450; AllianceGenome:HGNC:19364 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLEKHK1; bA531F24.1 Summary Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of NIK/NF-kappaB signaling. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lung (RPKM 32.1) and testis (RPKM 2.2) See more Orthologs mouse all
RTL1, Official Symbol RTL1provided by HGNC Official Full Name retrotransposon Gag like 1provided by HGNC Primary source HGNC:HGNC:14665 See related Ensembl:ENSG00000254656 MIM:611896; AllianceGenome:HGNC:14665 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HUR1; Mar1; MART1; PEG11; SIRH2 Summary This gene is a retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009] Orthologs mouse all
RTL10, Official Symbol RTL10provided by HGNC Official Full Name retrotransposon Gag like 10provided by HGNC Primary source HGNC:HGNC:26112 See related Ensembl:ENSG00000215012 AllianceGenome:HGNC:26112 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BOP; C22orf29 Summary Involved in mitochondrial outer membrane permeabilization and regulation of mitochondrial membrane potential. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 6.6), brain (RPKM 5.5) and 25 other tissues See more Orthologs all
RTL3, Official Symbol RTL3provided by HGNC Official Full Name retrotransposon Gag like 3provided by HGNC Primary source HGNC:HGNC:22997 See related Ensembl:ENSG00000179300 AllianceGenome:HGNC:22997 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mar3; ZHC5; Mart3; SIRH9; ZCCHC5 Summary This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. [provided by RefSeq, Nov 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all
RTL4, Official Symbol RTL4provided by HGNC Official Full Name retrotransposon Gag like 4provided by HGNC Primary source HGNC:HGNC:25214 See related Ensembl:ENSG00000187823 AllianceGenome:HGNC:25214 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mar4; Mart4; SIRH11; ZCCHC16 Summary Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to act upstream of or within cognition and norepinephrine metabolic process. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
RTL5, Official Symbol RTL5provided by HGNC Official Full Name retrotransposon Gag like 5provided by HGNC Primary source HGNC:HGNC:29430 See related Ensembl:ENSG00000242732 AllianceGenome:HGNC:29430 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAR5; MART5; RGAG4; SIRH8; 6430402L03Rik Expression Broad expression in brain (RPKM 6.6), testis (RPKM 6.2) and 24 other tissues See more Orthologs mouse all
RTL6, Official Symbol RTL6provided by HGNC Official Full Name retrotransposon Gag like 6provided by HGNC Primary source HGNC:HGNC:13343 See related Ensembl:ENSG00000188636 AllianceGenome:HGNC:13343 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mar6; Mart6; SIRH3; LDOC1L; dJ1033E15.2 Expression Ubiquitous expression in brain (RPKM 18.2), ovary (RPKM 11.8) and 25 other tissues See more Orthologs mouse all
RTL8A, Official Symbol RTL8Aprovided by HGNC Official Full Name retrotransposon Gag like 8Aprovided by HGNC Primary source HGNC:HGNC:24514 See related Ensembl:ENSG00000203950 AllianceGenome:HGNC:24514 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXX1b; MAR8A; SIRH6; FAM127B Summary Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 21.7), fat (RPKM 19.6) and 25 other tissues See more Orthologs all
RTL8B, Official Symbol RTL8Bprovided by HGNC Official Full Name retrotransposon Gag like 8Bprovided by HGNC Primary source HGNC:HGNC:33156 See related Ensembl:ENSG00000212747 AllianceGenome:HGNC:33156 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXX1c; MAR8B; SIRH4; FAM127C Summary Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
RTL8C, Official Symbol RTL8Cprovided by HGNC Official Full Name retrotransposon Gag like 8Cprovided by HGNC Primary source HGNC:HGNC:2569 See related Ensembl:ENSG00000134590 MIM:300213; AllianceGenome:HGNC:2569 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXX1; Mar8; MAR8C; Mart8; SIRH5; MART8C; FAM127A Summary Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
RTL9, Official Symbol RTL9provided by HGNC Official Full Name retrotransposon Gag like 9provided by HGNC Primary source HGNC:HGNC:29245 See related Ensembl:ENSG00000243978 MIM:300965; AllianceGenome:HGNC:29245 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAR9; MART9; RGAG1; SIRH10 Expression Restricted expression toward testis (RPKM 5.0) See more Orthologs mouse all
RTN1, Official Symbol RTN1provided by HGNC Official Full Name reticulon 1provided by HGNC Primary source HGNC:HGNC:10467 See related Ensembl:ENSG00000139970 MIM:600865; AllianceGenome:HGNC:10467 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSP Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011] Expression Biased expression in brain (RPKM 96.0) and spleen (RPKM 6.9) See more Orthologs mouse all
RTN2, Official Symbol RTN2provided by HGNC Official Full Name reticulon 2provided by HGNC Primary source HGNC:HGNC:10468 See related Ensembl:ENSG00000125744 MIM:603183; AllianceGenome:HGNC:10468 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSP2; NSPL1; NSPLI; SPG12 Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an important role in the replication of positive-strand RNA (ssRNA) viruses. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Aug 2020] Expression Broad expression in brain (RPKM 9.6), placenta (RPKM 7.1) and 22 other tissues See more Orthologs mouse all
RTN3, Official Symbol RTN3provided by HGNC Official Full Name reticulon 3provided by HGNC Primary source HGNC:HGNC:10469 See related Ensembl:ENSG00000133318 MIM:604249; AllianceGenome:HGNC:10469 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAP; ASYIP; NSPL2; NSPLII; RTN3-A1 Summary This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012] Expression Broad expression in brain (RPKM 157.4), fat (RPKM 54.4) and 23 other tissues See more Orthologs mouse all
RTN3P1, Official Symbol RTN3P1provided by HGNC Official Full Name reticulon 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:19212 See related AllianceGenome:HGNC:19212 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSPLII; RTN3PS
RTN4, Official Symbol RTN4provided by HGNC Official Full Name reticulon 4provided by HGNC Primary source HGNC:HGNC:14085 See related Ensembl:ENSG00000115310 MIM:604475; AllianceGenome:HGNC:14085 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASY; NSP; NOGO; RTN-X; NSP-CL; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545 Summary This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 122.1), brain (RPKM 104.7) and 24 other tissues See more Orthologs mouse all
RTN4IP1, Official Symbol RTN4IP1provided by HGNC Official Full Name reticulon 4 interacting protein 1provided by HGNC Primary source HGNC:HGNC:18647 See related Ensembl:ENSG00000130347 MIM:610502; AllianceGenome:HGNC:18647 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIMP; OPA10 Summary This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in skin (RPKM 10.5), placenta (RPKM 7.8) and 24 other tissues See more Orthologs mouse all
RTN4R, Official Symbol RTN4Rprovided by HGNC Official Full Name reticulon 4 receptorprovided by HGNC Primary source HGNC:HGNC:18601 See related Ensembl:ENSG00000040608 MIM:605566; AllianceGenome:HGNC:18601 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NGR; NOGOR Summary This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 7.7), spleen (RPKM 2.5) and 10 other tissues See more Orthologs mouse all
RTN4RL1, Official Symbol RTN4RL1provided by HGNC Official Full Name reticulon 4 receptor like 1provided by HGNC Primary source HGNC:HGNC:21329 See related Ensembl:ENSG00000185924 MIM:610461; AllianceGenome:HGNC:21329 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NgR3; NGRH2 Summary Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 5.0), fat (RPKM 3.0) and 14 other tissues See more Orthologs mouse all
RTN4RL2, Official Symbol RTN4RL2provided by HGNC Official Full Name reticulon 4 receptor like 2provided by HGNC Primary source HGNC:HGNC:23053 See related Ensembl:ENSG00000186907 MIM:610462; AllianceGenome:HGNC:23053 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NgR2; NGRH1 Summary Enables signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; corpus callosum development; and negative regulation of neuron projection development. Located in cell surface. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 9.9), thyroid (RPKM 5.5) and 6 other tissues See more Orthologs mouse all
RTP1, Official Symbol RTP1provided by HGNC Official Full Name receptor transporter protein 1provided by HGNC Primary source HGNC:HGNC:28580 See related Ensembl:ENSG00000175077 MIM:609137; AllianceGenome:HGNC:28580 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Z3CXXC1 Summary Enables olfactory receptor binding activity. Involved in protein insertion into membrane. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
RTP2, Official Symbol RTP2provided by HGNC Official Full Name receptor transporter protein 2provided by HGNC Primary source HGNC:HGNC:32486 See related Ensembl:ENSG00000198471 MIM:609138; AllianceGenome:HGNC:32486 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Z3CXXC2 Summary Enables olfactory receptor binding activity. Involved in protein insertion into membrane. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
RTP3, Official Symbol RTP3provided by HGNC Official Full Name receptor transporter protein 3provided by HGNC Primary source HGNC:HGNC:15572 See related Ensembl:ENSG00000163825 MIM:607181; AllianceGenome:HGNC:15572 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LTM1; TMEM7; Z3CXXC3 Summary Predicted to enable olfactory receptor binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and protein targeting to membrane. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward liver (RPKM 19.8) See more Orthologs mouse all
RTP4, Official Symbol RTP4provided by HGNC Official Full Name receptor transporter protein 4provided by HGNC Primary source HGNC:HGNC:23992 See related Ensembl:ENSG00000136514 MIM:609350; AllianceGenome:HGNC:23992 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFRG28; Z3CXXC4 Summary Predicted to enable olfactory receptor binding activity. Involved in defense response to virus; detection of chemical stimulus involved in sensory perception of bitter taste; and protein targeting to membrane. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in urinary bladder (RPKM 8.4), duodenum (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
RTP5, Official Symbol RTP5provided by HGNC Official Full Name receptor transporter protein 5 (putative)provided by HGNC Primary source HGNC:HGNC:26585 See related Ensembl:ENSG00000188011 AllianceGenome:HGNC:26585 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXXC11; C2orf85; Z3CXXC5 Summary Predicted to enable olfactory receptor binding activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste; protein insertion into membrane; and protein targeting to membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 2.7), lymph node (RPKM 0.5) and 3 other tissues See more Orthologs all
RTRAF, Official Symbol RTRAFprovided by HGNC Official Full Name RNA transcription, translation and transport factorprovided by HGNC Primary source HGNC:HGNC:23169 See related Ensembl:ENSG00000087302 MIM:610858; AllianceGenome:HGNC:23169 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLE; CLE7; hCLE; CGI99; RLLM1; hCLE1; CGI-99; LCRP369; C14orf166 Summary Enables RNA binding activity; RNA polymerase II complex binding activity; and identical protein binding activity. Involved in negative regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; and tRNA splicing, via endonucleolytic cleavage and ligation. Located in microtubule cytoskeleton; nucleoplasm; and perinuclear region of cytoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 109.7), fat (RPKM 62.2) and 25 other tissues See more Orthologs mouse all
RTTN, Official Symbol RTTNprovided by HGNC Official Full Name rotatinprovided by HGNC Primary source HGNC:HGNC:18654 See related Ensembl:ENSG00000176225 MIM:610436; AllianceGenome:HGNC:18654 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSSP Summary This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in testis (RPKM 2.7), ovary (RPKM 1.5) and 25 other tissues See more Orthologs mouse all
RUBCN, Official Symbol RUBCNprovided by HGNC Official Full Name rubicon autophagy regulatorprovided by HGNC Primary source HGNC:HGNC:28991 See related Ensembl:ENSG00000145016 MIM:613516; AllianceGenome:HGNC:28991 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCAR15; RUBICON; KIAA0226 Summary The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014] Expression Ubiquitous expression in testis (RPKM 7.0), brain (RPKM 6.7) and 25 other tissues See more Orthologs mouse all
RUBCNL, Official Symbol RUBCNLprovided by HGNC Official Full Name rubicon like autophagy enhancerprovided by HGNC Primary source HGNC:HGNC:20420 See related Ensembl:ENSG00000102445 MIM:620175; AllianceGenome:HGNC:20420 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PACER; C13orf18; KIAA0226L Summary This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017] Expression Biased expression in lymph node (RPKM 14.1), spleen (RPKM 8.4) and 13 other tissues See more Orthologs mouse all
RUFY1, Official Symbol RUFY1provided by HGNC Official Full Name RUN and FYVE domain containing 1provided by HGNC Primary source HGNC:HGNC:19760 See related Ensembl:ENSG00000176783 MIM:610327; AllianceGenome:HGNC:19760 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RABIP4; ZFYVE12 Summary This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in spleen (RPKM 10.3), thyroid (RPKM 9.1) and 25 other tissues See more Orthologs mouse all
RUFY1-AS1, Official Symbol RUFY1-AS1provided by HGNC Official Full Name RUFY1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40903 See related Ensembl:ENSG00000244945 AllianceGenome:HGNC:40903 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
RUFY2, Official Symbol RUFY2provided by HGNC Official Full Name RUN and FYVE domain containing 2provided by HGNC Primary source HGNC:HGNC:19761 See related Ensembl:ENSG00000204130 MIM:610328; AllianceGenome:HGNC:19761 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RABIP4R; ZFYVE13 Summary Enables SH3 domain binding activity. Predicted to be involved in regulation of endocytosis. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 7.8), endometrium (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
RUFY3, Official Symbol RUFY3provided by HGNC Official Full Name RUN and FYVE domain containing 3provided by HGNC Primary source HGNC:HGNC:30285 See related Ensembl:ENSG00000018189 MIM:611194; AllianceGenome:HGNC:30285 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIPX; SINGAR1; ZFYVE30 Summary This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in brain (RPKM 27.2), testis (RPKM 10.8) and 24 other tissues See more Orthologs mouse all
RUFY4, Official Symbol RUFY4provided by HGNC Official Full Name RUN and FYVE domain containing 4provided by HGNC Primary source HGNC:HGNC:24804 See related Ensembl:ENSG00000188282 AllianceGenome:HGNC:24804 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFYVE31 Summary Enables phosphatidylinositol-3-phosphate binding activity. Involved in autophagosome assembly; cellular response to interleukin-4; and positive regulation of macroautophagy. Located in autophagosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 1.0), lymph node (RPKM 0.6) and 16 other tissues See more Orthologs mouse all
RUNDC1, Official Symbol RUNDC1provided by HGNC Official Full Name RUN domain containing 1provided by HGNC Primary source HGNC:HGNC:25418 See related Ensembl:ENSG00000198863 MIM:619250; AllianceGenome:HGNC:25418 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RUND1 Summary This gene encodes a protein that contains a RUN (RPIP8, UNC-14 and NESCA) domain and a coiled coil domain. The encoded protein may negatively regulate p53 transcriptional activity. This gene is a potential candidate gene for predisposition to glioma in humans. [provided by RefSeq, May 2017] Expression Ubiquitous expression in brain (RPKM 7.5), thyroid (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
RUNDC3A, Official Symbol RUNDC3Aprovided by HGNC Official Full Name RUN domain containing 3Aprovided by HGNC Primary source HGNC:HGNC:16984 See related Ensembl:ENSG00000108309 MIM:605448; AllianceGenome:HGNC:16984 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPIP8; RAP2IP; RPIP-8 Summary Predicted to enable GTPase regulator activity. Predicted to be involved in positive regulation of cGMP-mediated signaling. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 51.0), adrenal (RPKM 6.3) and 1 other tissue See more Orthologs mouse all
RUNDC3B, Official Symbol RUNDC3Bprovided by HGNC Official Full Name RUN domain containing 3Bprovided by HGNC Primary source HGNC:HGNC:30286 See related Ensembl:ENSG00000105784 MIM:617295; AllianceGenome:HGNC:30286 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPIB9; RPIP9 Expression Broad expression in adrenal (RPKM 7.8), brain (RPKM 4.9) and 16 other tissues See more Orthologs mouse all
RUNX1, Official Symbol RUNX1provided by HGNC Official Full Name RUNX family transcription factor 1provided by HGNC Primary source HGNC:HGNC:10471 See related Ensembl:ENSG00000159216 MIM:151385; AllianceGenome:HGNC:10471 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; CBF2alpha; AML1-EVI-1; PEBP2alpha Summary Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 7.9), bone marrow (RPKM 7.3) and 24 other tissues See more Orthologs mouse all
RUNX1T1, Official Symbol RUNX1T1provided by HGNC Official Full Name RUNX1 partner transcriptional co-repressor 1provided by HGNC Primary source HGNC:HGNC:1535 See related Ensembl:ENSG00000079102 MIM:133435; AllianceGenome:HGNC:1535 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8 Summary This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in endometrium (RPKM 1.9), brain (RPKM 1.3) and 22 other tissues See more Orthologs mouse all
RUNX2, Official Symbol RUNX2provided by HGNC Official Full Name RUNX family transcription factor 2provided by HGNC Primary source HGNC:HGNC:10472 See related Ensembl:ENSG00000124813 MIM:600211; AllianceGenome:HGNC:10472 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1 Summary This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016] Expression Broad expression in bone marrow (RPKM 1.9), appendix (RPKM 1.3) and 23 other tissues See more Orthologs mouse all
RUNX3, Official Symbol RUNX3provided by HGNC Official Full Name RUNX family transcription factor 3provided by HGNC Primary source HGNC:HGNC:10473 See related Ensembl:ENSG00000020633 MIM:600210; AllianceGenome:HGNC:10473 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AML2; CBFA3; PEBP2aC Summary This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Biased expression in bone marrow (RPKM 19.5), spleen (RPKM 16.7) and 12 other tissues See more Orthologs mouse all
RUNX3-AS1, Official Symbol RUNX3-AS1provided by HGNC Official Full Name RUNX3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40513 See related AllianceGenome:HGNC:40513 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
RUSC1, Official Symbol RUSC1provided by HGNC Official Full Name RUN and SH3 domain containing 1provided by HGNC Primary source HGNC:HGNC:17153 See related Ensembl:ENSG00000160753 MIM:617318; AllianceGenome:HGNC:17153 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NESCA Summary Predicted to enable actin binding activity. Involved in protein polyubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 8.6), prostate (RPKM 6.2) and 25 other tissues See more Orthologs mouse all
RUSC1-AS1, Official Symbol RUSC1-AS1provided by HGNC Official Full Name RUSC1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:26680 See related Ensembl:ENSG00000225855 AllianceGenome:HGNC:26680 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1orf104 Expression Ubiquitous expression in liver (RPKM 11.7), duodenum (RPKM 11.0) and 25 other tissues See more Orthologs all
RUSC2, Official Symbol RUSC2provided by HGNC Official Full Name RUN and SH3 domain containing 2provided by HGNC Primary source HGNC:HGNC:23625 See related Ensembl:ENSG00000198853 MIM:611053; AllianceGenome:HGNC:23625 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT61; Iporin Summary This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012] Expression Ubiquitous expression in brain (RPKM 15.6), testis (RPKM 11.8) and 25 other tissues See more Orthologs mouse all
RUSF1, Official Symbol RUSF1provided by HGNC Official Full Name RUS family member 1provided by HGNC Primary source HGNC:HGNC:25848 See related Ensembl:ENSG00000140688 AllianceGenome:HGNC:25848 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RUS; C16orf58 Summary This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013] Expression Ubiquitous expression in ovary (RPKM 35.8), thyroid (RPKM 32.9) and 25 other tissues See more Orthologs mouse all