psui3905/ncbi_genes_summary huggingface dataset:
KLF13, Official Symbol KLF13provided by HGNC Official Full Name KLF transcription factor 13provided by HGNC Primary source HGNC:HGNC:13672 See related Ensembl:ENSG00000169926 MIM:605328; AllianceGenome:HGNC:13672 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BTEB3; FKLF2; NSLP1; RFLAT1; RFLAT-1 Summary KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in bone marrow (RPKM 34.5), lung (RPKM 27.2) and 24 other tissues See more Orthologs mouse all
KLF14, Official Symbol KLF14provided by HGNC Official Full Name KLF transcription factor 14provided by HGNC Primary source HGNC:HGNC:23025 See related Ensembl:ENSG00000266265 MIM:609393; AllianceGenome:HGNC:23025 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BTEB5 Summary This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013] Orthologs mouse all
KLF15, Official Symbol KLF15provided by HGNC Official Full Name KLF transcription factor 15provided by HGNC Primary source HGNC:HGNC:14536 See related Ensembl:ENSG00000163884 MIM:606465; AllianceGenome:HGNC:14536 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KKLF Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 10.7), ovary (RPKM 8.2) and 17 other tissues See more Orthologs mouse all
KLF16, Official Symbol KLF16provided by HGNC Official Full Name KLF transcription factor 16provided by HGNC Primary source HGNC:HGNC:16857 See related Ensembl:ENSG00000129911 MIM:606139; AllianceGenome:HGNC:16857 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRRF; BTEB4; NSLP2 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within dopamine receptor signaling pathway. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.7), colon (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
KLF17, Official Symbol KLF17provided by HGNC Official Full Name KLF transcription factor 17provided by HGNC Primary source HGNC:HGNC:18830 See related Ensembl:ENSG00000171872 MIM:609602; AllianceGenome:HGNC:18830 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZLF393; ZNF393; Zfp393 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within gamete generation. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 3.2), endometrium (RPKM 0.4) and 5 other tissues See more Orthologs mouse all
KLF17P1, Official Symbol KLF17P1provided by HGNC Official Full Name Kruppel like factor 17 pseudogene 1provided by HGNC Primary source HGNC:HGNC:41521 See related AllianceGenome:HGNC:41521 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
KLF18, Official Symbol KLF18provided by HGNC Official Full Name KLF transcription factor 18provided by HGNC Primary source HGNC:HGNC:51793 See related Ensembl:ENSG00000283039 AllianceGenome:HGNC:51793 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
KLF2, Official Symbol KLF2provided by HGNC Official Full Name KLF transcription factor 2provided by HGNC Primary source HGNC:HGNC:6347 See related Ensembl:ENSG00000127528 MIM:602016; AllianceGenome:HGNC:6347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LKLF Summary This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017] Expression Broad expression in fat (RPKM 40.2), ovary (RPKM 23.1) and 19 other tissues See more Orthologs mouse all
KLF2P2, Official Symbol KLF2P2provided by HGNC Official Full Name Kruppel like factor 2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:49281 See related Ensembl:ENSG00000230646 AllianceGenome:HGNC:49281 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
KLF2P4, Official Symbol KLF2P4provided by HGNC Official Full Name Kruppel like factor 2 pseudogene 4provided by HGNC Primary source HGNC:HGNC:49283 See related AllianceGenome:HGNC:49283 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
KLF3, Official Symbol KLF3provided by HGNC Official Full Name KLF transcription factor 3provided by HGNC Primary source HGNC:HGNC:16516 See related Ensembl:ENSG00000109787 MIM:609392; AllianceGenome:HGNC:16516 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BKLF Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 22.1), gall bladder (RPKM 19.2) and 25 other tissues See more Orthologs mouse all
KLF3-AS1, Official Symbol KLF3-AS1provided by HGNC Official Full Name KLF3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:25796 See related AllianceGenome:HGNC:25796 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in ovary (RPKM 5.9), endometrium (RPKM 4.7) and 25 other tissues See more
KLF4, Official Symbol KLF4provided by HGNC Official Full Name KLF transcription factor 4provided by HGNC Primary source HGNC:HGNC:6348 See related Ensembl:ENSG00000136826 MIM:602253; AllianceGenome:HGNC:6348 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EZF; GKLF Summary This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] Expression Broad expression in colon (RPKM 75.2), esophagus (RPKM 73.6) and 22 other tissues See more Orthologs mouse all
KLF4P1, Official Symbol KLF4P1provided by HGNC Official Full Name KLF4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49738 See related Ensembl:ENSG00000233186 AllianceGenome:HGNC:49738 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
KLF5, Official Symbol KLF5provided by HGNC Official Full Name KLF transcription factor 5provided by HGNC Primary source HGNC:HGNC:6349 See related Ensembl:ENSG00000102554 MIM:602903; AllianceGenome:HGNC:6349 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKLF; IKLF; BTEB2 Summary This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] Expression Broad expression in skin (RPKM 92.1), esophagus (RPKM 91.6) and 14 other tissues See more Orthologs mouse all
KLF6, Official Symbol KLF6provided by HGNC Official Full Name KLF transcription factor 6provided by HGNC Primary source HGNC:HGNC:2235 See related Ensembl:ENSG00000067082 MIM:602053; AllianceGenome:HGNC:2235 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GBF; ZF9; BCD1; CBA1; CPBP; PAC1; ST12; COPEB Summary This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009] Expression Ubiquitous expression in bone marrow (RPKM 165.8), gall bladder (RPKM 117.9) and 25 other tissues See more Orthologs mouse all
KLF7, Official Symbol KLF7provided by HGNC Official Full Name KLF transcription factor 7provided by HGNC Primary source HGNC:HGNC:6350 See related Ensembl:ENSG00000118263 MIM:604865; AllianceGenome:HGNC:6350 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UKLF Summary The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues See more Orthologs mouse all
KLF8, Official Symbol KLF8provided by HGNC Official Full Name KLF transcription factor 8provided by HGNC Primary source HGNC:HGNC:6351 See related Ensembl:ENSG00000102349 MIM:300286; AllianceGenome:HGNC:6351 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BKLF3; ZNF741 Summary This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] Expression Broad expression in skin (RPKM 8.2), fat (RPKM 3.4) and 20 other tissues See more Orthologs mouse all
KLF9, Official Symbol KLF9provided by HGNC Official Full Name KLF transcription factor 9provided by HGNC Primary source HGNC:HGNC:1123 See related Ensembl:ENSG00000119138 MIM:602902; AllianceGenome:HGNC:1123 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BTEB; BTEB1 Summary The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 44.7), gall bladder (RPKM 34.1) and 25 other tissues See more Orthologs mouse all
KLHDC1, Official Symbol KLHDC1provided by HGNC Official Full Name kelch domain containing 1provided by HGNC Primary source HGNC:HGNC:19836 See related Ensembl:ENSG00000197776 MIM:611281; AllianceGenome:HGNC:19836 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST025 Summary Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Is active in Cul5-RING ubiquitin ligase complex and cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 2.8), thyroid (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
KLHDC10, Official Symbol KLHDC10provided by HGNC Official Full Name kelch domain containing 10provided by HGNC Primary source HGNC:HGNC:22194 See related Ensembl:ENSG00000128607 MIM:615152; AllianceGenome:HGNC:22194 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as slim; PNAS-138 Summary Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
KLHDC2, Official Symbol KLHDC2provided by HGNC Official Full Name kelch domain containing 2provided by HGNC Primary source HGNC:HGNC:20231 See related Ensembl:ENSG00000165516 MIM:611280; AllianceGenome:HGNC:20231 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCP; HCLP1; HCLP-1 Summary Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nuclear body and nuclear membrane. Is active in Cul2-RING ubiquitin ligase complex and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 22.9), kidney (RPKM 22.5) and 25 other tissues See more Orthologs mouse all
KLHDC3, Official Symbol KLHDC3provided by HGNC Official Full Name kelch domain containing 3provided by HGNC Primary source HGNC:HGNC:20704 See related Ensembl:ENSG00000124702 MIM:611248; AllianceGenome:HGNC:20704 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PEAS; dJ20C7.3 Summary The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012] Expression Broad expression in testis (RPKM 98.0), brain (RPKM 70.2) and 25 other tissues See more Orthologs mouse all
KLHDC4, Official Symbol KLHDC4provided by HGNC Official Full Name kelch domain containing 4provided by HGNC Primary source HGNC:HGNC:25272 See related Ensembl:ENSG00000104731 AllianceGenome:HGNC:25272 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 2.9), lymph node (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
KLHDC7A, Official Symbol KLHDC7Aprovided by HGNC Official Full Name kelch domain containing 7Aprovided by HGNC Primary source HGNC:HGNC:26791 See related Ensembl:ENSG00000179023 AllianceGenome:HGNC:26791 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
KLHDC7B, Official Symbol KLHDC7Bprovided by HGNC Official Full Name kelch domain containing 7Bprovided by HGNC Primary source HGNC:HGNC:25145 See related Ensembl:ENSG00000130487 AllianceGenome:HGNC:25145 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs mouse all
KLHDC8A, Official Symbol KLHDC8Aprovided by HGNC Official Full Name kelch domain containing 8Aprovided by HGNC Primary source HGNC:HGNC:25573 See related Ensembl:ENSG00000162873 MIM:614503; AllianceGenome:HGNC:25573 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] Expression Biased expression in ovary (RPKM 76.6) and adrenal (RPKM 7.3) See more Orthologs mouse all
KLHDC8B, Official Symbol KLHDC8Bprovided by HGNC Official Full Name kelch domain containing 8Bprovided by HGNC Primary source HGNC:HGNC:28557 See related Ensembl:ENSG00000185909 MIM:613169; AllianceGenome:HGNC:28557 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHL Summary This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010] Expression Ubiquitous expression in adrenal (RPKM 31.3), ovary (RPKM 23.4) and 23 other tissues See more Orthologs mouse all
KLHDC9, Official Symbol KLHDC9provided by HGNC Official Full Name kelch domain containing 9provided by HGNC Primary source HGNC:HGNC:28489 See related Ensembl:ENSG00000162755 MIM:617375; AllianceGenome:HGNC:28489 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KARCA1 Summary Enables cyclin binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 19.7), kidney (RPKM 4.9) and 14 other tissues See more Orthologs mouse all
KLHL1, Official Symbol KLHL1provided by HGNC Official Full Name kelch like family member 1provided by HGNC Primary source HGNC:HGNC:6352 See related Ensembl:ENSG00000150361 MIM:605332; AllianceGenome:HGNC:6352 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRP2 Summary The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000 [PubMed 10888605]).[supplied by OMIM, Feb 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
KLHL10, Official Symbol KLHL10provided by HGNC Official Full Name kelch like family member 10provided by HGNC Primary source HGNC:HGNC:18829 See related Ensembl:ENSG00000161594 MIM:608778; AllianceGenome:HGNC:18829 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPGF11 Summary The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016] Expression Restricted expression toward testis (RPKM 27.6) See more Orthologs mouse all
KLHL11, Official Symbol KLHL11provided by HGNC Official Full Name kelch like family member 11provided by HGNC Primary source HGNC:HGNC:19008 See related Ensembl:ENSG00000178502 MIM:619078; AllianceGenome:HGNC:19008 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 5.8), brain (RPKM 4.6) and 25 other tissues See more Orthologs mouse all
KLHL12, Official Symbol KLHL12provided by HGNC Official Full Name kelch like family member 12provided by HGNC Primary source HGNC:HGNC:19360 See related Ensembl:ENSG00000117153 MIM:614522; AllianceGenome:HGNC:19360 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKIR; C3IP1 Summary This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in testis (RPKM 23.4), brain (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
KLHL13, Official Symbol KLHL13provided by HGNC Official Full Name kelch like family member 13provided by HGNC Primary source HGNC:HGNC:22931 See related Ensembl:ENSG00000003096 MIM:300655; AllianceGenome:HGNC:22931 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BKLHD2 Summary This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Expression Broad expression in endometrium (RPKM 9.9), kidney (RPKM 3.7) and 15 other tissues See more Orthologs mouse all
KLHL14, Official Symbol KLHL14provided by HGNC Official Full Name kelch like family member 14provided by HGNC Primary source HGNC:HGNC:29266 See related Ensembl:ENSG00000197705 MIM:613772; AllianceGenome:HGNC:29266 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015] Expression Biased expression in thyroid (RPKM 4.4), spleen (RPKM 2.8) and 10 other tissues See more Orthologs mouse all
KLHL15, Official Symbol KLHL15provided by HGNC Official Full Name kelch like family member 15provided by HGNC Primary source HGNC:HGNC:29347 See related Ensembl:ENSG00000174010 MIM:300980; AllianceGenome:HGNC:29347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XLID103; HEL-S-305 Summary This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. [provided by RefSeq, Apr 2009] Expression Broad expression in bone marrow (RPKM 22.1), testis (RPKM 14.8) and 22 other tissues See more Orthologs mouse all
KLHL17, Official Symbol KLHL17provided by HGNC Official Full Name kelch like family member 17provided by HGNC Primary source HGNC:HGNC:24023 See related Ensembl:ENSG00000187961 MIM:619262; AllianceGenome:HGNC:24023 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AF Summary The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in testis (RPKM 3.5), skin (RPKM 2.8) and 24 other tissues See more Orthologs mouse all
KLHL18, Official Symbol KLHL18provided by HGNC Official Full Name kelch like family member 18provided by HGNC Primary source HGNC:HGNC:29120 See related Ensembl:ENSG00000114648 MIM:619926; AllianceGenome:HGNC:29120 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in positive regulation of mitotic cell cycle phase transition and protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 6.1), skin (RPKM 5.8) and 25 other tissues See more Orthologs mouse all
KLHL2, Official Symbol KLHL2provided by HGNC Official Full Name kelch like family member 2provided by HGNC Primary source HGNC:HGNC:6353 See related Ensembl:ENSG00000109466 MIM:605774; AllianceGenome:HGNC:6353 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAV; MAYVEN; ABP-KELCH Summary Enables actin binding activity and identical protein binding activity. Predicted to be involved in protein ubiquitination. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 27.3), esophagus (RPKM 8.4) and 24 other tissues See more Orthologs mouse all
KLHL20, Official Symbol KLHL20provided by HGNC Official Full Name kelch like family member 20provided by HGNC Primary source HGNC:HGNC:25056 See related Ensembl:ENSG00000076321 MIM:617679; AllianceGenome:HGNC:25056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KHLHX; KLEIP; KLHLX Summary The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 10.0), fat (RPKM 7.7) and 25 other tissues See more Orthologs mouse all
KLHL21, Official Symbol KLHL21provided by HGNC Official Full Name kelch like family member 21provided by HGNC Primary source HGNC:HGNC:29041 See related Ensembl:ENSG00000162413 MIM:616262; AllianceGenome:HGNC:29041 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 17.4), ovary (RPKM 14.2) and 25 other tissues See more Orthologs mouse all
KLHL22, Official Symbol KLHL22provided by HGNC Official Full Name kelch like family member 22provided by HGNC Primary source HGNC:HGNC:25888 See related Ensembl:ENSG00000099910 MIM:618020; AllianceGenome:HGNC:25888 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KELCHL Summary Enables 14-3-3 protein binding activity. Involved in several processes, including cellular protein metabolic process; cellular response to leucine; and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including cytosol; intercellular bridge; and microtubule cytoskeleton. Part of Cul3-RING ubiquitin ligase complex. Colocalizes with lysosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 3.8), thyroid (RPKM 3.7) and 25 other tissues See more Orthologs mouse all
KLHL23, Official Symbol KLHL23provided by HGNC Official Full Name kelch like family member 23provided by HGNC Primary source HGNC:HGNC:27506 See related Ensembl:ENSG00000213160 AllianceGenome:HGNC:27506 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DITHP Expression Ubiquitous expression in endometrium (RPKM 12.1), brain (RPKM 7.8) and 22 other tissues See more Orthologs mouse all
KLHL24, Official Symbol KLHL24provided by HGNC Official Full Name kelch like family member 24provided by HGNC Primary source HGNC:HGNC:25947 See related Ensembl:ENSG00000114796 MIM:611295; AllianceGenome:HGNC:25947 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRE1; EBS6; CMH29; EBSSH; KRIP6 Summary The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in heart (RPKM 9.5), thyroid (RPKM 9.3) and 25 other tissues See more Orthologs mouse all
KLHL25, Official Symbol KLHL25provided by HGNC Official Full Name kelch like family member 25provided by HGNC Primary source HGNC:HGNC:25732 See related Ensembl:ENSG00000183655 MIM:619893; AllianceGenome:HGNC:25732 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ENC2; ENC-2 Summary Involved in protein ubiquitination; regulation of translational initiation; and ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 6.7), testis (RPKM 5.6) and 23 other tissues See more Orthologs mouse all
KLHL26, Official Symbol KLHL26provided by HGNC Official Full Name kelch like family member 26provided by HGNC Primary source HGNC:HGNC:25623 See related Ensembl:ENSG00000167487 AllianceGenome:HGNC:25623 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 4.1), kidney (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
KLHL28, Official Symbol KLHL28provided by HGNC Official Full Name kelch like family member 28provided by HGNC Primary source HGNC:HGNC:19741 See related Ensembl:ENSG00000179454 AllianceGenome:HGNC:19741 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BTBD5 Expression Ubiquitous expression in brain (RPKM 3.6), thyroid (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
KLHL29, Official Symbol KLHL29provided by HGNC Official Full Name kelch like family member 29provided by HGNC Primary source HGNC:HGNC:29404 See related Ensembl:ENSG00000119771 AllianceGenome:HGNC:29404 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KBTBD9 Expression Ubiquitous expression in adrenal (RPKM 5.0), prostate (RPKM 2.9) and 24 other tissues See more Orthologs mouse all
KLHL2P1, Official Symbol KLHL2P1provided by HGNC Official Full Name kelch like family member 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44046 See related Ensembl:ENSG00000250412 AllianceGenome:HGNC:44046 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAVP1
KLHL3, Official Symbol KLHL3provided by HGNC Official Full Name kelch like family member 3provided by HGNC Primary source HGNC:HGNC:6354 See related Ensembl:ENSG00000146021 MIM:605775; AllianceGenome:HGNC:6354 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PHA2D Summary This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012] Expression Broad expression in thyroid (RPKM 5.9), heart (RPKM 4.0) and 23 other tissues See more Orthologs mouse all
KLHL30, Official Symbol KLHL30provided by HGNC Official Full Name kelch like family member 30provided by HGNC Primary source HGNC:HGNC:24770 See related Ensembl:ENSG00000168427 AllianceGenome:HGNC:24770 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in heart (RPKM 3.1), fat (RPKM 2.9) and 10 other tissues See more Orthologs mouse all
KLHL31, Official Symbol KLHL31provided by HGNC Official Full Name kelch like family member 31provided by HGNC Primary source HGNC:HGNC:21353 See related Ensembl:ENSG00000124743 MIM:610749; AllianceGenome:HGNC:21353 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLHL; BKLHD6; KBTBD1; bA345L23.2 Summary Involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in heart (RPKM 15.6), fat (RPKM 6.5) and 1 other tissue See more Orthologs mouse all
KLHL32, Official Symbol KLHL32provided by HGNC Official Full Name kelch like family member 32provided by HGNC Primary source HGNC:HGNC:21221 See related Ensembl:ENSG00000186231 AllianceGenome:HGNC:21221 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BKLHD5; KIAA1900; dJ21F7.1; UG0030H05 Expression Biased expression in brain (RPKM 4.5), testis (RPKM 0.6) and 7 other tissues See more Orthologs mouse all
KLHL33, Official Symbol KLHL33provided by HGNC Official Full Name kelch like family member 33provided by HGNC Primary source HGNC:HGNC:31952 See related Ensembl:ENSG00000185271 AllianceGenome:HGNC:31952 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more Orthologs mouse all
KLHL34, Official Symbol KLHL34provided by HGNC Official Full Name kelch like family member 34provided by HGNC Primary source HGNC:HGNC:26634 See related Ensembl:ENSG00000185915 AllianceGenome:HGNC:26634 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
KLHL35, Official Symbol KLHL35provided by HGNC Official Full Name kelch like family member 35provided by HGNC Primary source HGNC:HGNC:26597 See related Ensembl:ENSG00000149243 AllianceGenome:HGNC:26597 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 1.5), brain (RPKM 0.7) and 6 other tissues See more Orthologs mouse all
KLHL36, Official Symbol KLHL36provided by HGNC Official Full Name kelch like family member 36provided by HGNC Primary source HGNC:HGNC:17844 See related Ensembl:ENSG00000135686 AllianceGenome:HGNC:17844 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C16orf44 Summary Enables cullin family protein binding activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
KLHL38, Official Symbol KLHL38provided by HGNC Official Full Name kelch like family member 38provided by HGNC Primary source HGNC:HGNC:34435 See related Ensembl:ENSG00000175946 AllianceGenome:HGNC:34435 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C8ORFK36 Expression Biased expression in heart (RPKM 17.1) and esophagus (RPKM 1.0) See more Orthologs mouse all
KLHL4, Official Symbol KLHL4provided by HGNC Official Full Name kelch like family member 4provided by HGNC Primary source HGNC:HGNC:6355 See related Ensembl:ENSG00000102271 MIM:300348; AllianceGenome:HGNC:6355 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KHL4; DKELCHL Summary This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 14.7), testis (RPKM 4.7) and 4 other tissues See more Orthologs mouse all