psui3905/ncbi_genes_summary huggingface dataset:
SRGAP2, Official Symbol SRGAP2provided by HGNC Official Full Name SLIT-ROBO Rho GTPase activating protein 2provided by HGNC Primary source HGNC:HGNC:19751 See related Ensembl:ENSG00000266028 MIM:606524; AllianceGenome:HGNC:19751 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FNBP2; SRGAP3; SRGAP2A; ARHGAP34 Summary This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in skin (RPKM 12.4), spleen (RPKM 10.1) and 23 other tissues See more Orthologs mouse all
SRGAP2-AS1, Official Symbol SRGAP2-AS1provided by HGNC Official Full Name SRGAP2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40902 See related Ensembl:ENSG00000230806 AllianceGenome:HGNC:40902 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
SRGAP2B, Official Symbol SRGAP2Bprovided by HGNC Official Full Name SLIT-ROBO Rho GTPase activating protein 2Bprovided by HGNC Primary source HGNC:HGNC:35237 See related Ensembl:ENSG00000196369 MIM:614703; AllianceGenome:HGNC:35237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRGAP2L; SRGAP2P2 Summary This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in skin (RPKM 9.5), spleen (RPKM 7.9) and 23 other tissues See more
SRGAP2C, Official Symbol SRGAP2Cprovided by HGNC Official Full Name SLIT-ROBO Rho GTPase activating protein 2Cprovided by HGNC Primary source HGNC:HGNC:30584 See related Ensembl:ENSG00000171943 MIM:614704; AllianceGenome:HGNC:30584 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRGAP2P1 Summary This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2B locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2, and acts antagonistically to these proteins in cortical neuron development. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in skin (RPKM 12.8), spleen (RPKM 10.6) and 23 other tissues See more
SRGAP3, Official Symbol SRGAP3provided by HGNC Official Full Name SLIT-ROBO Rho GTPase activating protein 3provided by HGNC Primary source HGNC:HGNC:19744 See related Ensembl:ENSG00000196220 MIM:606525; AllianceGenome:HGNC:19744 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WRP; MEGAP; SRGAP2; ARHGAP14 Summary Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 6.5), urinary bladder (RPKM 1.5) and 16 other tissues See more Orthologs mouse all
SRGAP3-AS1, Official Symbol SRGAP3-AS1provided by HGNC Official Full Name SRGAP3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40898 See related AllianceGenome:HGNC:40898 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
SRGAP3-AS2, Official Symbol SRGAP3-AS2provided by HGNC Official Full Name SRGAP3 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40899 See related Ensembl:ENSG00000228723 AllianceGenome:HGNC:40899 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in lung (RPKM 2.8), adrenal (RPKM 0.4) and 1 other tissue See more
SRGAP3-AS3, Official Symbol SRGAP3-AS3provided by HGNC Official Full Name SRGAP3 antisense RNA 3provided by HGNC Primary source HGNC:HGNC:40900 See related Ensembl:ENSG00000227929 AllianceGenome:HGNC:40900 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.0) See more
SRGAP3-AS4, Official Symbol SRGAP3-AS4provided by HGNC Official Full Name SRGAP3 antisense RNA 4provided by HGNC Primary source HGNC:HGNC:42434 See related Ensembl:ENSG00000235830 AllianceGenome:HGNC:42434 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
SRGN, Official Symbol SRGNprovided by HGNC Official Full Name serglycinprovided by HGNC Primary source HGNC:HGNC:9361 See related Ensembl:ENSG00000122862 MIM:177040; AllianceGenome:HGNC:9361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPG; PRG; PRG1 Summary This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010] Expression Biased expression in bone marrow (RPKM 1650.2), appendix (RPKM 289.1) and 5 other tissues See more Orthologs mouse all
SRGNP1, Official Symbol SRGNP1provided by HGNC Official Full Name serglycin pseudogene 1provided by HGNC Primary source HGNC:HGNC:49107 See related Ensembl:ENSG00000271386 AllianceGenome:HGNC:49107 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRI, Official Symbol SRIprovided by HGNC Official Full Name sorcinprovided by HGNC Primary source HGNC:HGNC:11292 See related Ensembl:ENSG00000075142 MIM:182520; AllianceGenome:HGNC:11292 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCN; V19; CP22; CP-22 Summary This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012] Expression Broad expression in colon (RPKM 86.4), brain (RPKM 64.5) and 24 other tissues See more Orthologs mouse all
SRI-AS1, Official Symbol SRI-AS1provided by HGNC Official Full Name SRI antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40564 See related AllianceGenome:HGNC:40564 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in colon (RPKM 32.5), small intestine (RPKM 15.3) and 21 other tissues See more
SRIP1, Official Symbol SRIP1provided by HGNC Official Full Name sorcin pseudogene 1provided by HGNC Primary source HGNC:HGNC:11293 See related AllianceGenome:HGNC:11293 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRIL
SRIP2, Official Symbol SRIP2provided by HGNC Official Full Name sorcin pseudogene 2provided by HGNC Primary source HGNC:HGNC:38734 See related AllianceGenome:HGNC:38734 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRIP3, Official Symbol SRIP3provided by HGNC Official Full Name sorcin pseudogene 3provided by HGNC Primary source HGNC:HGNC:38735 See related Ensembl:ENSG00000224953 AllianceGenome:HGNC:38735 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRL, Official Symbol SRLprovided by HGNC Official Full Name sarcalumeninprovided by HGNC Primary source HGNC:HGNC:11295 See related Ensembl:ENSG00000185739 MIM:604992; AllianceGenome:HGNC:11295 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAR Summary Predicted to enable GTP binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to act upstream of or within response to muscle activity involved in regulation of muscle adaptation and store-operated calcium entry. Predicted to be located in sarcoplasmic reticulum lumen and sarcoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in heart (RPKM 76.3), prostate (RPKM 4.3) and 1 other tissue See more Orthologs mouse all
SRM, Official Symbol SRMprovided by HGNC Official Full Name spermidine synthaseprovided by HGNC Primary source HGNC:HGNC:11296 See related Ensembl:ENSG00000116649 MIM:182891; AllianceGenome:HGNC:11296 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAPT; SPS1; SPDSY; SRML1 Summary The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues See more Orthologs mouse all
SRMS, Official Symbol SRMSprovided by HGNC Official Full Name src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesprovided by HGNC Primary source HGNC:HGNC:11298 See related Ensembl:ENSG00000125508 MIM:617797; AllianceGenome:HGNC:11298 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRM; PTK70; C20orf148; dJ697K14.1 Summary Enables protein tyrosine kinase activity. Involved in peptidyl-tyrosine autophosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in prostate (RPKM 1.4), stomach (RPKM 1.2) and 15 other tissues See more Orthologs mouse all
SRP14, Official Symbol SRP14provided by HGNC Official Full Name signal recognition particle 14provided by HGNC Primary source HGNC:HGNC:11299 See related Ensembl:ENSG00000140319 MIM:600708; AllianceGenome:HGNC:11299 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALURBP Summary Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 125.3), adrenal (RPKM 118.3) and 25 other tissues See more Orthologs mouse all
SRP14P1, Official Symbol SRP14P1provided by HGNC Official Full Name SRP14 pseudogene 1provided by HGNC Primary source HGNC:HGNC:33181 See related AllianceGenome:HGNC:33181 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRP14P2, Official Symbol SRP14P2provided by HGNC Official Full Name SRP14 pseudogene 2provided by HGNC Primary source HGNC:HGNC:53768 See related Ensembl:ENSG00000234106 AllianceGenome:HGNC:53768 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRP14P3, Official Symbol SRP14P3provided by HGNC Official Full Name SRP14 pseudogene 3provided by HGNC Primary source HGNC:HGNC:53769 See related Ensembl:ENSG00000235183 AllianceGenome:HGNC:53769 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRP14P4, Official Symbol SRP14P4provided by HGNC Official Full Name SRP14 pseudogene 4provided by HGNC Primary source HGNC:HGNC:53770 See related Ensembl:ENSG00000268062 AllianceGenome:HGNC:53770 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRP19, Official Symbol SRP19provided by HGNC Official Full Name signal recognition particle 19provided by HGNC Primary source HGNC:HGNC:11300 See related Ensembl:ENSG00000153037 MIM:182175; AllianceGenome:HGNC:11300 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 11.2), bone marrow (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
SRP54, Official Symbol SRP54provided by HGNC Official Full Name signal recognition particle 54provided by HGNC Primary source HGNC:HGNC:11301 See related Ensembl:ENSG00000100883 MIM:604857; AllianceGenome:HGNC:11301 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCN8 Summary Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 26.2), thyroid (RPKM 18.4) and 25 other tissues See more Orthologs all
SRP68, Official Symbol SRP68provided by HGNC Official Full Name signal recognition particle 68provided by HGNC Primary source HGNC:HGNC:11302 See related Ensembl:ENSG00000167881 MIM:604858; AllianceGenome:HGNC:11302 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012] Expression Ubiquitous expression in thyroid (RPKM 29.4), esophagus (RPKM 22.8) and 25 other tissues See more Orthologs mouse all
SRP68P1, Official Symbol SRP68P1provided by HGNC Official Full Name signal recognition particle 68 pseudogene 1provided by HGNC Primary source HGNC:HGNC:30427 See related Ensembl:ENSG00000266129 AllianceGenome:HGNC:30427 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRPSMCR
SRP68P2, Official Symbol SRP68P2provided by HGNC Official Full Name signal recognition particle 68 pseudogene 2provided by HGNC Primary source HGNC:HGNC:30426 See related Ensembl:ENSG00000227689 AllianceGenome:HGNC:30426 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRPSMCR
SRP68P3, Official Symbol SRP68P3provided by HGNC Official Full Name signal recognition particle 68 pseudogene 3provided by HGNC Primary source HGNC:HGNC:30428 See related Ensembl:ENSG00000237911 AllianceGenome:HGNC:30428 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRPSMCR
SRP72, Official Symbol SRP72provided by HGNC Official Full Name signal recognition particle 72provided by HGNC Primary source HGNC:HGNC:11303 See related Ensembl:ENSG00000174780 MIM:602122; AllianceGenome:HGNC:11303 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BMFF; BMFS1; HEL103 Summary This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012] Expression Ubiquitous expression in thyroid (RPKM 21.7), lymph node (RPKM 15.4) and 25 other tissues See more Orthologs mouse all
SRP72P1, Official Symbol SRP72P1provided by HGNC Official Full Name signal recognition particle 72 pseudogene 1provided by HGNC Primary source HGNC:HGNC:31095 See related Ensembl:ENSG00000265182 AllianceGenome:HGNC:31095 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRP72P2, Official Symbol SRP72P2provided by HGNC Official Full Name signal recognition particle 72 pseudogene 2provided by HGNC Primary source HGNC:HGNC:31096 See related Ensembl:ENSG00000188451 AllianceGenome:HGNC:31096 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ274L14.2
SRP9, Official Symbol SRP9provided by HGNC Official Full Name signal recognition particle 9provided by HGNC Primary source HGNC:HGNC:11304 See related Ensembl:ENSG00000143742 MIM:600707; AllianceGenome:HGNC:11304 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALURBP Summary Predicted to enable RNA binding activity and signal recognition particle binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytosol. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 131.7), brain (RPKM 102.1) and 25 other tissues See more Orthologs mouse all
SRPK1, Official Symbol SRPK1provided by HGNC Official Full Name SRSF protein kinase 1provided by HGNC Primary source HGNC:HGNC:11305 See related Ensembl:ENSG00000096063 MIM:601939; AllianceGenome:HGNC:11305 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFRSK1 Summary This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010] Expression Broad expression in testis (RPKM 31.4), bone marrow (RPKM 17.2) and 25 other tissues See more Orthologs mouse all
SRPK2, Official Symbol SRPK2provided by HGNC Official Full Name SRSF protein kinase 2provided by HGNC Primary source HGNC:HGNC:11306 See related Ensembl:ENSG00000135250 MIM:602980; AllianceGenome:HGNC:11306 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFRSK2 Summary Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nucleic acid metabolic process; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues See more Orthologs mouse all
SRPK2P, Official Symbol SRPK2Pprovided by HGNC Official Full Name SRSF protein kinase 2 pseudogeneprovided by HGNC Primary source HGNC:HGNC:30303 See related Ensembl:ENSG00000253431 AllianceGenome:HGNC:30303 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRPK2ps
SRPK3, Official Symbol SRPK3provided by HGNC Official Full Name SRSF protein kinase 3provided by HGNC Primary source HGNC:HGNC:11402 See related Ensembl:ENSG00000184343 MIM:301002; AllianceGenome:HGNC:11402 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSSK1; STK23; MSSK-1 Summary This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Biased expression in heart (RPKM 9.9), prostate (RPKM 3.3) and 7 other tissues See more Orthologs mouse all
SRPRA, Official Symbol SRPRAprovided by HGNC Official Full Name SRP receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:11307 See related Ensembl:ENSG00000182934 MIM:182180; AllianceGenome:HGNC:11307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DP; SRPR; Sralpha Summary The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] Expression Ubiquitous expression in thyroid (RPKM 41.3), salivary gland (RPKM 33.7) and 25 other tissues See more Orthologs mouse all
SRPRB, Official Symbol SRPRBprovided by HGNC Official Full Name SRP receptor subunit betaprovided by HGNC Primary source HGNC:HGNC:24085 See related Ensembl:ENSG00000144867 MIM:616883; AllianceGenome:HGNC:24085 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APMCF1; SR-beta Summary The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 18.4), testis (RPKM 17.1) and 25 other tissues See more Orthologs mouse all
SRPX, Official Symbol SRPXprovided by HGNC Official Full Name sushi repeat containing protein X-linkedprovided by HGNC Primary source HGNC:HGNC:11309 See related Ensembl:ENSG00000101955 MIM:300187; AllianceGenome:HGNC:11309 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRS; ETX1; SRPX1; HEL-S-83p Summary Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in placenta (RPKM 49.3), fat (RPKM 34.8) and 19 other tissues See more Orthologs mouse all
SRPX2, Official Symbol SRPX2provided by HGNC Official Full Name sushi repeat containing protein X-linked 2provided by HGNC Primary source HGNC:HGNC:30668 See related Ensembl:ENSG00000102359 MIM:300642; AllianceGenome:HGNC:30668 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPP; CBPS; PMGX; RESDX; SRPUL Summary This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and cognitive disability. [provided by RefSeq, May 2010] Expression Broad expression in urinary bladder (RPKM 13.2), placenta (RPKM 7.8) and 18 other tissues See more Orthologs mouse all
SRR, Official Symbol SRRprovided by HGNC Official Full Name serine racemaseprovided by HGNC Primary source HGNC:HGNC:14398 See related Ensembl:ENSG00000167720 MIM:606477; AllianceGenome:HGNC:14398 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILV1; ISO1 Summary Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and anion binding activity. Involved in pyruvate biosynthetic process; response to lipopolysaccharide; and serine family amino acid metabolic process. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.5), testis (RPKM 6.3) and 25 other tissues See more Orthologs mouse all
SRRD, Official Symbol SRRDprovided by HGNC Official Full Name SRR1 domain containingprovided by HGNC Primary source HGNC:HGNC:33910 See related Ensembl:ENSG00000100104 MIM:602254; AllianceGenome:HGNC:33910 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRR1L; HC/HCC Summary Predicted to be involved in microtubule-based process; regulation of circadian rhythm; and regulation of heme biosynthetic process. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 8.9), testis (RPKM 8.0) and 25 other tissues See more Orthologs mouse all
SRRM1, Official Symbol SRRM1provided by HGNC Official Full Name serine and arginine repetitive matrix 1provided by HGNC Primary source HGNC:HGNC:16638 See related Ensembl:ENSG00000133226 MIM:605975; AllianceGenome:HGNC:16638 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 160-KD; POP101; SRM160 Summary Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nuclear speck. Part of catalytic step 2 spliceosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 22.6), prostate (RPKM 22.3) and 25 other tissues See more Orthologs mouse all
SRRM2, Official Symbol SRRM2provided by HGNC Official Full Name serine/arginine repetitive matrix 2provided by HGNC Primary source HGNC:HGNC:16639 See related Ensembl:ENSG00000167978 MIM:606032; AllianceGenome:HGNC:16639 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CWF21; Cwc21; MRD72; 300-KD; SRL300; SRm300; HSPC075 Summary Enables C2H2 zinc finger domain binding activity and protein N-terminus binding activity. Involved in mRNA splicing, via spliceosome. Located in Cajal body and nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Biomarker of Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 88.4), bone marrow (RPKM 86.9) and 25 other tissues See more Orthologs mouse all
SRRM2-AS1, Official Symbol SRRM2-AS1provided by HGNC Official Full Name SRRM2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44162 See related Ensembl:ENSG00000205913 AllianceGenome:HGNC:44162 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 4.9), prostate (RPKM 0.4) and 2 other tissues See more
SRRM3, Official Symbol SRRM3provided by HGNC Official Full Name serine/arginine repetitive matrix 3provided by HGNC Primary source HGNC:HGNC:26729 See related Ensembl:ENSG00000177679 AllianceGenome:HGNC:26729 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable mRNA binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in adrenal (RPKM 3.7), brain (RPKM 3.0) and 17 other tissues See more Orthologs mouse all
SRRM4, Official Symbol SRRM4provided by HGNC Official Full Name serine/arginine repetitive matrix 4provided by HGNC Primary source HGNC:HGNC:29389 See related Ensembl:ENSG00000139767 MIM:613103; AllianceGenome:HGNC:29389 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as nSR100; KIAA1853; MU-MB-2.76 Summary SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009] Expression Biased expression in brain (RPKM 5.9) and adrenal (RPKM 0.7) See more Orthologs mouse all
SRRM5, Official Symbol SRRM5provided by HGNC Official Full Name serine/arginine repetitive matrix 5provided by HGNC Primary source HGNC:HGNC:37248 See related Ensembl:ENSG00000226763 AllianceGenome:HGNC:37248 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF576 Orthologs all
SRRT, Official Symbol SRRTprovided by HGNC Official Full Name serrate, RNA effector moleculeprovided by HGNC Primary source HGNC:HGNC:24101 See related Ensembl:ENSG00000087087 MIM:614469; AllianceGenome:HGNC:24101 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARS2; ASR2; serrate Summary Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 66.3), bone marrow (RPKM 37.2) and 25 other tissues See more Orthologs mouse all
SRSF1, Official Symbol SRSF1provided by HGNC Official Full Name serine and arginine rich splicing factor 1provided by HGNC Primary source HGNC:HGNC:10780 See related Ensembl:ENSG00000136450 MIM:600812; AllianceGenome:HGNC:10780 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASF; SF2; SFRS1; NEDFBA; SF2p33; SRp30a Summary This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014] Expression Ubiquitous expression in lymph node (RPKM 44.8), appendix (RPKM 40.8) and 25 other tissues See more Orthologs mouse all
SRSF10, Official Symbol SRSF10provided by HGNC Official Full Name serine and arginine rich splicing factor 10provided by HGNC Primary source HGNC:HGNC:16713 See related Ensembl:ENSG00000188529 MIM:605221; AllianceGenome:HGNC:16713 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149 Summary This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in bone marrow (RPKM 28.7), lymph node (RPKM 12.7) and 25 other tissues See more Orthologs mouse all
SRSF11, Official Symbol SRSF11provided by HGNC Official Full Name serine and arginine rich splicing factor 11provided by HGNC Primary source HGNC:HGNC:10782 See related Ensembl:ENSG00000116754 MIM:602010; AllianceGenome:HGNC:10782 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p54; NET2; SFRS11; dJ677H15.2 Summary This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010] Expression Ubiquitous expression in bone marrow (RPKM 46.2), skin (RPKM 32.0) and 25 other tissues See more Orthologs mouse all
SRSF12, Official Symbol SRSF12provided by HGNC Official Full Name serine and arginine rich splicing factor 12provided by HGNC Primary source HGNC:HGNC:21220 See related Ensembl:ENSG00000154548 AllianceGenome:HGNC:21220 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFRS19; SRrp35; SFRS13B Summary Enables RNA binding activity. Involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 7.8), brain (RPKM 2.4) and 6 other tissues See more Orthologs mouse all
SRSF2, Official Symbol SRSF2provided by HGNC Official Full Name serine and arginine rich splicing factor 2provided by HGNC Primary source HGNC:HGNC:10783 See related Ensembl:ENSG00000161547 MIM:600813; AllianceGenome:HGNC:10783 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SC35; PR264; SC-35; SFRS2; SFRS2A; SRp30b Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010] Expression Ubiquitous expression in bone marrow (RPKM 91.7), lymph node (RPKM 69.7) and 25 other tissues See more Orthologs mouse all
SRSF2P1, Official Symbol SRSF2P1provided by HGNC Official Full Name SRSF2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54922 See related Ensembl:ENSG00000236072 AllianceGenome:HGNC:54922 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRSF3, Official Symbol SRSF3provided by HGNC Official Full Name serine and arginine rich splicing factor 3provided by HGNC Primary source HGNC:HGNC:10785 See related Ensembl:ENSG00000112081 MIM:603364; AllianceGenome:HGNC:10785 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFRS3; SRp20 Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010] Expression Ubiquitous expression in bone marrow (RPKM 107.3), lymph node (RPKM 60.0) and 25 other tissues See more Orthologs mouse all
SRSF3P1, Official Symbol SRSF3P1provided by HGNC Official Full Name SRSF3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54691 See related AllianceGenome:HGNC:54691 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRSF3P2, Official Symbol SRSF3P2provided by HGNC Official Full Name SRSF3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:54692 See related AllianceGenome:HGNC:54692 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRSF3P4, Official Symbol SRSF3P4provided by HGNC Official Full Name SRSF3 pseudogene 4provided by HGNC Primary source HGNC:HGNC:54693 See related AllianceGenome:HGNC:54693 Gene type pseudo RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
SRSF4, Official Symbol SRSF4provided by HGNC Official Full Name serine and arginine rich splicing factor 4provided by HGNC Primary source HGNC:HGNC:10786 See related Ensembl:ENSG00000116350 MIM:601940; AllianceGenome:HGNC:10786 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFRS4; SRP75 Summary Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 33.0), bone marrow (RPKM 32.4) and 25 other tissues See more Orthologs mouse all