psui3905/ncbi_genes_summary huggingface dataset:
IGLVIV-65, Official Symbol IGLVIV-65provided by HGNC Official Full Name immunoglobulin lambda variable (IV)-65 (pseudogene)provided by HGNC Primary source HGNC:HGNC:5944 See related Ensembl:ENSG00000254161 IMGT/GENE-DB:IGLV(IV)-65; AllianceGenome:HGNC:5944 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as V4-9P; IGLVIV65; IGLV(IV)-65
IGLVIVOR22-2, Official Symbol IGLVIVOR22-2provided by HGNC Official Full Name immunoglobulin lambda variable (IV)/OR22-2 (pseudogene)provided by HGNC Primary source HGNC:HGNC:15695 See related IMGT/GENE-DB:IGLV(IV)/OR22-2; AllianceGenome:HGNC:15695 Gene type pseudo Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
IGLVV-58, Official Symbol IGLVV-58provided by HGNC Official Full Name immunoglobulin lambda variable (V)-58 (pseudogene)provided by HGNC Primary source HGNC:HGNC:5945 See related Ensembl:ENSG00000253637 IMGT/GENE-DB:IGLV(V)-58; AllianceGenome:HGNC:5945 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as V5-3P; IGLVV58; IGLV(V)-58
IGLVV-66, Official Symbol IGLVV-66provided by HGNC Official Full Name immunoglobulin lambda variable (V)-66 (pseudogene)provided by HGNC Primary source HGNC:HGNC:5946 See related Ensembl:ENSG00000254075 IMGT/GENE-DB:IGLV(V)-66; AllianceGenome:HGNC:5946 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as V5-5P; IGLVV66; IGLV(V)-66
IGLVVI-22-1, Official Symbol IGLVVI-22-1provided by HGNC Official Full Name immunoglobulin lambda variable (VI)-22-1 (pseudogene)provided by HGNC Primary source HGNC:HGNC:15689 See related IMGT/GENE-DB:IGLV(VI)-22-1; AllianceGenome:HGNC:15689 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Lvg2
IGLVVI-25-1, Official Symbol IGLVVI-25-1provided by HGNC Official Full Name immunoglobulin lambda variable (VI)-25-1 (pseudogene)provided by HGNC Primary source HGNC:HGNC:15690 See related IMGT/GENE-DB:IGLV(VI)-25-1; AllianceGenome:HGNC:15690 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as lambdavg3
IGSF1, Official Symbol IGSF1provided by HGNC Official Full Name immunoglobulin superfamily member 1provided by HGNC Primary source HGNC:HGNC:5948 See related Ensembl:ENSG00000147255 MIM:300137; AllianceGenome:HGNC:5948 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHTE; p120; IGCD1; IGDC1; INHBP; PGSF2 Summary This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] Expression Biased expression in testis (RPKM 3.9), adrenal (RPKM 3.4) and 13 other tissues See more Orthologs mouse all
IGSF10, Official Symbol IGSF10provided by HGNC Official Full Name immunoglobulin superfamily member 10provided by HGNC Primary source HGNC:HGNC:26384 See related Ensembl:ENSG00000152580 MIM:617351; AllianceGenome:HGNC:26384 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMF608 Summary Predicted to be involved in regulation of neuron migration. Predicted to act upstream of or within ossification. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in gall bladder (RPKM 9.0), ovary (RPKM 8.9) and 19 other tissues See more Orthologs mouse all
IGSF11, Official Symbol IGSF11provided by HGNC Official Full Name immunoglobulin superfamily member 11provided by HGNC Primary source HGNC:HGNC:16669 See related Ensembl:ENSG00000144847 MIM:608351; AllianceGenome:HGNC:16669 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT119; VSIG3; BTIGSF; Igsf13; BT-IgSF; CXADRL1 Summary IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005] Expression Biased expression in testis (RPKM 12.0), brain (RPKM 8.3) and 4 other tissues See more Orthologs mouse all
IGSF11-AS1, Official Symbol IGSF11-AS1provided by HGNC Official Full Name IGSF11 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40777 See related Ensembl:ENSG00000239877 AllianceGenome:HGNC:40777 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 12.6) See more
IGSF21, Official Symbol IGSF21provided by HGNC Official Full Name immunoglobin superfamily member 21provided by HGNC Primary source HGNC:HGNC:28246 See related Ensembl:ENSG00000117154 AllianceGenome:HGNC:28246 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011] Expression Biased expression in brain (RPKM 11.7), spleen (RPKM 6.4) and 6 other tissues See more Orthologs mouse all
IGSF22, Official Symbol IGSF22provided by HGNC Official Full Name immunoglobulin superfamily member 22provided by HGNC Primary source HGNC:HGNC:26750 See related Ensembl:ENSG00000179057 AllianceGenome:HGNC:26750 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGFN2 Expression Broad expression in kidney (RPKM 2.8), skin (RPKM 1.7) and 21 other tissues See more Orthologs mouse all
IGSF23, Official Symbol IGSF23provided by HGNC Official Full Name immunoglobulin superfamily member 23provided by HGNC Primary source HGNC:HGNC:40040 See related Ensembl:ENSG00000216588 AllianceGenome:HGNC:40040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011] Expression Biased expression in small intestine (RPKM 1.4), duodenum (RPKM 1.3) and 3 other tissues See more Orthologs mouse all
IGSF3, Official Symbol IGSF3provided by HGNC Official Full Name immunoglobulin superfamily member 3provided by HGNC Primary source HGNC:HGNC:5950 See related Ensembl:ENSG00000143061 MIM:603491; AllianceGenome:HGNC:5950 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as V8; LCDD; EWI-3 Summary The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016] Expression Broad expression in esophagus (RPKM 8.2), skin (RPKM 7.8) and 19 other tissues See more Orthologs mouse all
IGSF5, Official Symbol IGSF5provided by HGNC Official Full Name immunoglobulin superfamily member 5provided by HGNC Primary source HGNC:HGNC:5952 See related Ensembl:ENSG00000183067 MIM:610638; AllianceGenome:HGNC:5952 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GSF5; JAM4 Summary Predicted to enable PDZ domain binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in apical plasma membrane. Predicted to be integral component of membrane. Predicted to be active in bicellular tight junction and cell surface. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
IGSF6, Official Symbol IGSF6provided by HGNC Official Full Name immunoglobulin superfamily member 6provided by HGNC Primary source HGNC:HGNC:5953 See related Ensembl:ENSG00000140749 MIM:606222; AllianceGenome:HGNC:5953 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DORA Summary Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in spleen (RPKM 32.0), appendix (RPKM 25.4) and 13 other tissues See more Orthologs mouse all
IGSF8, Official Symbol IGSF8provided by HGNC Official Full Name immunoglobulin superfamily member 8provided by HGNC Primary source HGNC:HGNC:17813 See related Ensembl:ENSG00000162729 MIM:606644; AllianceGenome:HGNC:17813 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1 Summary This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in brain (RPKM 17.6), skin (RPKM 9.6) and 24 other tissues See more Orthologs mouse all
IGSF9, Official Symbol IGSF9provided by HGNC Official Full Name immunoglobulin superfamily member 9provided by HGNC Primary source HGNC:HGNC:18132 See related Ensembl:ENSG00000085552 MIM:609738; AllianceGenome:HGNC:18132 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Nrt1; IGSF9A; FP18798 Summary Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within dendrite development and regulation of synapse organization. Predicted to be located in dendrite and inhibitory synapse. Predicted to be integral component of membrane. Predicted to be active in axon and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 12.2), stomach (RPKM 7.5) and 8 other tissues See more Orthologs mouse all
IGSF9B, Official Symbol IGSF9Bprovided by HGNC Official Full Name immunoglobulin superfamily member 9Bprovided by HGNC Primary source HGNC:HGNC:32326 See related Ensembl:ENSG00000080854 MIM:613773; AllianceGenome:HGNC:32326 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00947; MIR4697HG Summary Predicted to enable kinase binding activity. Predicted to be involved in synaptic membrane adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules and positive regulation of inhibitory postsynaptic potential. Predicted to be located in dendrite; inhibitory synapse; and neuronal cell body. Predicted to be active in GABA-ergic synapse; neuron projection; and postsynaptic specialization of symmetric synapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 1.7), testis (RPKM 1.1) and 21 other tissues See more Orthologs mouse all
IHH, Official Symbol IHHprovided by HGNC Official Full Name Indian hedgehog signaling moleculeprovided by HGNC Primary source HGNC:HGNC:5956 See related Ensembl:ENSG00000163501 MIM:600726; AllianceGenome:HGNC:5956 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDA1; HHG2 Summary This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015] Expression Biased expression in endometrium (RPKM 15.6), colon (RPKM 13.1) and 7 other tissues See more Orthologs mouse all
IHO1, Official Symbol IHO1provided by HGNC Official Full Name interactor of HORMAD1 1provided by HGNC Primary source HGNC:HGNC:27945 See related Ensembl:ENSG00000173421 MIM:619190; AllianceGenome:HGNC:27945 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT74; LELA1; CCDC36 Summary Predicted to be involved in gamete generation; meiosis I cell cycle process; and regulation of homologous chromosome segregation. Predicted to be active in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 12.6), fat (RPKM 1.6) and 1 other tissue See more Orthologs mouse all
IK, Official Symbol IKprovided by HGNC Official Full Name IK cytokineprovided by HGNC Primary source HGNC:HGNC:5958 See related Ensembl:ENSG00000113141 MIM:600549; AllianceGenome:HGNC:5958 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RED; RER; CSA2 Summary The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 59.6), bone marrow (RPKM 39.1) and 25 other tissues See more Orthologs mouse all
IKBIP, Official Symbol IKBIPprovided by HGNC Official Full Name IKBKB interacting proteinprovided by HGNC Primary source HGNC:HGNC:26430 See related Ensembl:ENSG00000166130 MIM:609861; AllianceGenome:HGNC:26430 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKIP Summary Predicted to be involved in response to X-ray. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 6.8), urinary bladder (RPKM 5.4) and 24 other tissues See more Orthologs mouse all
IKBKB, Official Symbol IKBKBprovided by HGNC Official Full Name inhibitor of nuclear factor kappa B kinase subunit betaprovided by HGNC Primary source HGNC:HGNC:5960 See related Ensembl:ENSG00000104365 MIM:603258; AllianceGenome:HGNC:5960 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKK2; IKKB; IKK-2; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta Summary The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in spleen (RPKM 14.6), lymph node (RPKM 12.4) and 25 other tissues See more Orthologs mouse all
IKBKE, Official Symbol IKBKEprovided by HGNC Official Full Name inhibitor of nuclear factor kappa B kinase subunit epsilonprovided by HGNC Primary source HGNC:HGNC:14552 See related Ensembl:ENSG00000263528 MIM:605048; AllianceGenome:HGNC:14552 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKKE; IKKI; IKK-E; IKK-i Summary IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] Expression Broad expression in lymph node (RPKM 9.0), appendix (RPKM 7.5) and 20 other tissues See more Orthologs mouse all
IKBKG, Official Symbol IKBKGprovided by HGNC Official Full Name inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by HGNC Primary source HGNC:HGNC:5961 See related Ensembl:ENSG00000269335 MIM:300248; AllianceGenome:HGNC:5961 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IP; IP1; IP2; FIP3; IKKG; IPD2; NEMO; FIP-3; Fip3p; IMD33; SAIDX; AMCBX1; EDAID1; IKKAP1; ZC2HC9; IKK-gamma Summary This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in spleen (RPKM 11.5), appendix (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
IKBKGP1, Official Symbol IKBKGP1provided by HGNC Official Full Name inhibitor of nuclear factor kappa B kinase subunit gamma pseudogene 1provided by HGNC Primary source HGNC:HGNC:24455 See related Ensembl:ENSG00000275882 AllianceGenome:HGNC:24455 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKBKGP; deltaNEMO
IKZF1, Official Symbol IKZF1provided by HGNC Official Full Name IKAROS family zinc finger 1provided by HGNC Primary source HGNC:HGNC:13176 See related Ensembl:ENSG00000185811 MIM:603023; AllianceGenome:HGNC:13176 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452 Summary This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014] Expression Biased expression in lymph node (RPKM 13.3), appendix (RPKM 8.6) and 10 other tissues See more Orthologs mouse all
IKZF2, Official Symbol IKZF2provided by HGNC Official Full Name IKAROS family zinc finger 2provided by HGNC Primary source HGNC:HGNC:13177 See related Ensembl:ENSG00000030419 MIM:606234; AllianceGenome:HGNC:13177 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANF1A2; HELIOS; ZNF1A2; ZNFN1A2 Summary This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 4.7), urinary bladder (RPKM 3.1) and 21 other tissues See more Orthologs mouse all
IKZF3, Official Symbol IKZF3provided by HGNC Official Full Name IKAROS family zinc finger 3provided by HGNC Primary source HGNC:HGNC:13178 See related Ensembl:ENSG00000161405 MIM:606221; AllianceGenome:HGNC:13178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIO; IMD84; AIOLOS; ZNFN1A3 Summary This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] Expression Biased expression in lymph node (RPKM 17.4), spleen (RPKM 11.5) and 10 other tissues See more Orthologs mouse all
IKZF4, Official Symbol IKZF4provided by HGNC Official Full Name IKAROS family zinc finger 4provided by HGNC Primary source HGNC:HGNC:13179 See related Ensembl:ENSG00000123411 MIM:606239; AllianceGenome:HGNC:13179 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EOS; ZNFN1A4 Summary Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002] Expression Ubiquitous expression in adrenal (RPKM 4.5), testis (RPKM 3.7) and 25 other tissues See more Orthologs mouse all
IKZF5, Official Symbol IKZF5provided by HGNC Official Full Name IKAROS family zinc finger 5provided by HGNC Primary source HGNC:HGNC:14283 See related Ensembl:ENSG00000095574 MIM:606238; AllianceGenome:HGNC:14283 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as THC7; PEGASUS; ZNFN1A5 Summary Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002] Expression Ubiquitous expression in bone marrow (RPKM 13.4), testis (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
IL10, Official Symbol IL10provided by HGNC Official Full Name interleukin 10provided by HGNC Primary source HGNC:HGNC:5962 See related Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSIF; TGIF; GVHDS; IL-10; IL10A Summary The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Broad expression in appendix (RPKM 3.8), lymph node (RPKM 2.5) and 16 other tissues See more Orthologs mouse all
IL10RA, Official Symbol IL10RAprovided by HGNC Official Full Name interleukin 10 receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:5964 See related Ensembl:ENSG00000110324 MIM:146933; AllianceGenome:HGNC:5964 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1 Summary The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] Expression Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues See more Orthologs mouse all
IL10RB, Official Symbol IL10RBprovided by HGNC Official Full Name interleukin 10 receptor subunit betaprovided by HGNC Primary source HGNC:HGNC:5965 See related Ensembl:ENSG00000243646 MIM:123889; AllianceGenome:HGNC:5965 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRFB4; IBD25; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB Summary The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues See more Orthologs mouse all
IL11, Official Symbol IL11provided by HGNC Official Full Name interleukin 11provided by HGNC Primary source HGNC:HGNC:5966 See related Ensembl:ENSG00000095752 MIM:147681; AllianceGenome:HGNC:5966 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGIF; IL-11 Summary The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012] Expression Biased expression in endometrium (RPKM 2.0), appendix (RPKM 1.5) and 8 other tissues See more Orthologs mouse all
IL11RA, Official Symbol IL11RAprovided by HGNC Official Full Name interleukin 11 receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:5967 See related Ensembl:ENSG00000137070 MIM:600939; AllianceGenome:HGNC:5967 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRSDA Summary Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012] Expression Ubiquitous expression in heart (RPKM 21.3), skin (RPKM 17.1) and 24 other tissues See more Orthologs mouse all
IL12A, Official Symbol IL12Aprovided by HGNC Official Full Name interleukin 12Aprovided by HGNC Primary source HGNC:HGNC:5969 See related Ensembl:ENSG00000168811 MIM:161560; AllianceGenome:HGNC:5969 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P35; CLMF; NFSK; NKSF1; IL-12A Summary This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 2.2), lung (RPKM 1.4) and 19 other tissues See more Orthologs mouse all
IL12A-AS1, Official Symbol IL12A-AS1provided by HGNC Official Full Name IL12A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49094 See related Ensembl:ENSG00000244040 AllianceGenome:HGNC:49094 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILAS1-AS1 Expression Biased expression in esophagus (RPKM 1.2), testis (RPKM 0.4) and 3 other tissues See more
IL12B, Official Symbol IL12Bprovided by HGNC Official Full Name interleukin 12Bprovided by HGNC Primary source HGNC:HGNC:5970 See related Ensembl:ENSG00000113302 MIM:161561; AllianceGenome:HGNC:5970 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B Summary This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL12RB1, Official Symbol IL12RB1provided by HGNC Official Full Name interleukin 12 receptor subunit beta 1provided by HGNC Primary source HGNC:HGNC:5971 See related Ensembl:ENSG00000096996 MIM:601604; AllianceGenome:HGNC:5971 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD212; IMD30; IL12RB; IL-12R-BETA1 Summary The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Biased expression in lymph node (RPKM 5.0), spleen (RPKM 4.1) and 13 other tissues See more Orthologs mouse all
IL12RB2, Official Symbol IL12RB2provided by HGNC Official Full Name interleukin 12 receptor subunit beta 2provided by HGNC Primary source HGNC:HGNC:5972 See related Ensembl:ENSG00000081985 MIM:601642; AllianceGenome:HGNC:5972 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012] Expression Broad expression in placenta (RPKM 2.3), brain (RPKM 0.9) and 18 other tissues See more Orthologs mouse all
IL13, Official Symbol IL13provided by HGNC Official Full Name interleukin 13provided by HGNC Primary source HGNC:HGNC:5973 See related Ensembl:ENSG00000169194 MIM:147683; AllianceGenome:HGNC:5973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P600; IL-13 Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 13.9) See more Orthologs mouse all
IL13RA1, Official Symbol IL13RA1provided by HGNC Official Full Name interleukin 13 receptor subunit alpha 1provided by HGNC Primary source HGNC:HGNC:5974 See related Ensembl:ENSG00000131724 MIM:300119; AllianceGenome:HGNC:5974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR4; CT19; CD213A1; IL-13Ra Summary The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues See more Orthologs mouse all
IL13RA2, Official Symbol IL13RA2provided by HGNC Official Full Name interleukin 13 receptor subunit alpha 2provided by HGNC Primary source HGNC:HGNC:5975 See related Ensembl:ENSG00000123496 MIM:300130; AllianceGenome:HGNC:5975 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT19; IL-13R; IL13BP; CD213A2 Summary The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 16.6), appendix (RPKM 2.7) and 6 other tissues See more Orthologs mouse all
IL15, Official Symbol IL15provided by HGNC Official Full Name interleukin 15provided by HGNC Primary source HGNC:HGNC:5977 See related Ensembl:ENSG00000164136 MIM:600554; AllianceGenome:HGNC:5977 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-15 Summary The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in spleen (RPKM 3.4), thyroid (RPKM 2.4) and 23 other tissues See more Orthologs mouse all
IL15RA, Official Symbol IL15RAprovided by HGNC Official Full Name interleukin 15 receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:5978 See related Ensembl:ENSG00000134470 MIM:601070; AllianceGenome:HGNC:5978 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD215 Summary This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010] Expression Ubiquitous expression in gall bladder (RPKM 5.8), lung (RPKM 5.5) and 24 other tissues See more Orthologs mouse all
IL16, Official Symbol IL16provided by HGNC Official Full Name interleukin 16provided by HGNC Primary source HGNC:HGNC:5980 See related Ensembl:ENSG00000172349 MIM:603035; AllianceGenome:HGNC:5980 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCF; NIL16; PRIL16; prIL-16 Summary The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] Expression Broad expression in lymph node (RPKM 15.8), spleen (RPKM 12.1) and 20 other tissues See more Orthologs mouse all