psui3905/ncbi_genes_summary huggingface dataset:
LSG1, Official Symbol LSG1provided by HGNC Official Full Name large 60S subunit nuclear export GTPase 1provided by HGNC Primary source HGNC:HGNC:25652 See related Ensembl:ENSG00000041802 MIM:610780; AllianceGenome:HGNC:25652 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009] Expression Ubiquitous expression in bone marrow (RPKM 9.7), thyroid (RPKM 9.6) and 25 other tissues See more Orthologs mouse all
LSINCT5, Official Symbol LSINCT5provided by HGNC Official Full Name long stress-induced non-coding transcript 5provided by HGNC Primary source HGNC:HGNC:37824 See related Ensembl:ENSG00000281560 MIM:615764; AllianceGenome:HGNC:37824 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LSM1, Official Symbol LSM1provided by HGNC Official Full Name LSM1 homolog, mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:20472 See related Ensembl:ENSG00000175324 MIM:607281; AllianceGenome:HGNC:20472 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CASM; YJL124C Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in heart (RPKM 16.1), placenta (RPKM 14.6) and 25 other tissues See more Orthologs mouse all
LSM10, Official Symbol LSM10provided by HGNC Official Full Name LSM10, U7 small nuclear RNA associatedprovided by HGNC Primary source HGNC:HGNC:17562 See related Ensembl:ENSG00000181817 MIM:617909; AllianceGenome:HGNC:17562 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST074; MSTP074 Summary Enables U7 snRNA binding activity. Involved in positive regulation of G1/S transition of mitotic cell cycle. Located in Cajal body. Part of U7 snRNP. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 20.1), spleen (RPKM 17.7) and 25 other tissues See more Orthologs mouse all
LSM11, Official Symbol LSM11provided by HGNC Official Full Name LSM11, U7 small nuclear RNA associatedprovided by HGNC Primary source HGNC:HGNC:30860 See related Ensembl:ENSG00000155858 MIM:617910; AllianceGenome:HGNC:30860 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGS8 Summary Enables U7 snRNA binding activity. Involved in positive regulation of G1/S transition of mitotic cell cycle. Located in nuclear body. Part of U7 snRNP and telomerase holoenzyme complex. Implicated in Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 3.6), testis (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
LSM12, Official Symbol LSM12provided by HGNC Official Full Name LSM12 homologprovided by HGNC Primary source HGNC:HGNC:26407 See related Ensembl:ENSG00000161654 MIM:611793; AllianceGenome:HGNC:26407 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PNAS-135 Expression Ubiquitous expression in testis (RPKM 15.2), placenta (RPKM 11.4) and 25 other tissues See more Orthologs mouse all
LSM14A, Official Symbol LSM14Aprovided by HGNC Official Full Name LSM14A mRNA processing body assembly factorprovided by HGNC Primary source HGNC:HGNC:24489 See related Ensembl:ENSG00000257103 MIM:610677; AllianceGenome:HGNC:24489 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAP55; FAM61A; RAP55A; C19orf13 Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in thyroid (RPKM 23.9), lymph node (RPKM 21.2) and 25 other tissues See more Orthologs mouse all
LSM14B, Official Symbol LSM14Bprovided by HGNC Official Full Name LSM family member 14Bprovided by HGNC Primary source HGNC:HGNC:15887 See related Ensembl:ENSG00000149657 AllianceGenome:HGNC:15887 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FT005; LSM13; FAM61B; RAP55B; C20orf40; bA11M20.3 Summary Enables RNA binding activity. Predicted to be involved in regulation of translation. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 18.4), brain (RPKM 13.1) and 25 other tissues See more Orthologs mouse all
LSM1P2, Official Symbol LSM1P2provided by HGNC Official Full Name LSM1 homolog, mRNA degradation associated pseudogene 2provided by HGNC Primary source HGNC:HGNC:49777 See related Ensembl:ENSG00000271679 AllianceGenome:HGNC:49777 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LSM2, Official Symbol LSM2provided by HGNC Official Full Name LSM2 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:13940 See related Ensembl:ENSG00000204392 MIM:607282; AllianceGenome:HGNC:13940 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G7B; snRNP; C6orf28; YBL026W Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in lymph node (RPKM 15.9), appendix (RPKM 13.7) and 25 other tissues See more Orthologs mouse all
LSM3, Official Symbol LSM3provided by HGNC Official Full Name LSM3 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:17874 See related Ensembl:ENSG00000170860 MIM:607283; AllianceGenome:HGNC:17874 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMX4; USS2; YLR438C Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in kidney (RPKM 53.9), fat (RPKM 40.8) and 25 other tissues See more Orthologs mouse all
LSM3P2, Official Symbol LSM3P2provided by HGNC Official Full Name LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated pseudogene 2provided by HGNC Primary source HGNC:HGNC:44347 See related AllianceGenome:HGNC:44347 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LSM4, Official Symbol LSM4provided by HGNC Official Full Name LSM4 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:17259 See related Ensembl:ENSG00000130520 MIM:607284; AllianceGenome:HGNC:17259 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRP; YER112W Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in testis (RPKM 22.8), colon (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
LSM5, Official Symbol LSM5provided by HGNC Official Full Name LSM5 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:17162 See related Ensembl:ENSG00000106355 MIM:607285; AllianceGenome:HGNC:17162 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YER146W Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in thyroid (RPKM 6.1), colon (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
LSM6, Official Symbol LSM6provided by HGNC Official Full Name LSM6 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:17017 See related Ensembl:ENSG00000164167 MIM:607286; AllianceGenome:HGNC:17017 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YDR378C Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in fat (RPKM 5.0), lymph node (RPKM 4.2) and 25 other tissues See more Orthologs mouse all
LSM7, Official Symbol LSM7provided by HGNC Official Full Name LSM7 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC Primary source HGNC:HGNC:20470 See related Ensembl:ENSG00000130332 MIM:607287; AllianceGenome:HGNC:20470 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YNL147W Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in colon (RPKM 29.6), bone marrow (RPKM 20.9) and 25 other tissues See more Orthologs mouse all
LSM8, Official Symbol LSM8provided by HGNC Official Full Name LSM8 homolog, U6 small nuclear RNA associatedprovided by HGNC Primary source HGNC:HGNC:20471 See related Ensembl:ENSG00000128534 MIM:607288; AllianceGenome:HGNC:20471 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAA38 Summary This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010] Annotation information Note: The name of this locus was changed from NAA38 to LSM8 by the HUGO Gene Nomenclature Committee. [23 Jan 2014] Expression Ubiquitous expression in lymph node (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues See more Orthologs mouse all
LSMEM1, Official Symbol LSMEM1provided by HGNC Official Full Name leucine rich single-pass membrane protein 1provided by HGNC Primary source HGNC:HGNC:22036 See related Ensembl:ENSG00000181016 AllianceGenome:HGNC:22036 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C7orf53 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
LSMEM2, Official Symbol LSMEM2provided by HGNC Official Full Name leucine rich single-pass membrane protein 2provided by HGNC Primary source HGNC:HGNC:26781 See related Ensembl:ENSG00000179564 AllianceGenome:HGNC:26781 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3orf45 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 6.3), prostate (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
LSP1, Official Symbol LSP1provided by HGNC Official Full Name lymphocyte specific protein 1provided by HGNC Primary source HGNC:HGNC:6707 See related Ensembl:ENSG00000130592 MIM:153432; AllianceGenome:HGNC:6707 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WP34; pp52 Summary This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 60.6), appendix (RPKM 43.3) and 19 other tissues See more Orthologs mouse all
LSP1P1, Official Symbol LSP1P1provided by HGNC Official Full Name LSP1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39716 See related Ensembl:ENSG00000269099 AllianceGenome:HGNC:39716 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LSP1P4, Official Symbol LSP1P4provided by HGNC Official Full Name LSP1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:53915 See related AllianceGenome:HGNC:53915 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in placenta (RPKM 15.8), kidney (RPKM 9.3) and 23 other tissues See more
LSP1P5, Official Symbol LSP1P5provided by HGNC Official Full Name LSP1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:50697 See related Ensembl:ENSG00000288905 AllianceGenome:HGNC:50697 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in placenta (RPKM 6.5), urinary bladder (RPKM 4.2) and 23 other tissues See more
LSR, Official Symbol LSRprovided by HGNC Official Full Name lipolysis stimulated lipoprotein receptorprovided by HGNC Primary source HGNC:HGNC:29572 See related Ensembl:ENSG00000105699 MIM:616582; AllianceGenome:HGNC:29572 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILDR3; LISCH7 Summary Predicted to be involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in stomach (RPKM 52.0), colon (RPKM 51.5) and 22 other tissues See more Orthologs mouse all
LSS, Official Symbol LSSprovided by HGNC Official Full Name lanosterol synthaseprovided by HGNC Primary source HGNC:HGNC:6708 See related Ensembl:ENSG00000160285 MIM:600909; AllianceGenome:HGNC:6708 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSC; APMR4; HYPT14; CTRCT44 Summary The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009] Expression Ubiquitous expression in skin (RPKM 17.0), lung (RPKM 14.7) and 25 other tissues See more Orthologs mouse all
LST1, Official Symbol LST1provided by HGNC Official Full Name leukocyte specific transcript 1provided by HGNC Primary source HGNC:HGNC:14189 See related Ensembl:ENSG00000204482 MIM:109170; AllianceGenome:HGNC:14189 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B144; LST-1; D6S49E Summary The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Biased expression in bone marrow (RPKM 68.1), spleen (RPKM 43.9) and 13 other tissues See more Orthologs mouse all
LTA, Official Symbol LTAprovided by HGNC Official Full Name lymphotoxin alphaprovided by HGNC Primary source HGNC:HGNC:6709 See related Ensembl:ENSG00000226979 MIM:153440; AllianceGenome:HGNC:6709 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LT; TNFB; TNFSF1; TNLG1E Summary The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Biased expression in lymph node (RPKM 3.5), appendix (RPKM 1.7) and 7 other tissues See more Orthologs mouse all
LTA4H, Official Symbol LTA4Hprovided by HGNC Official Full Name leukotriene A4 hydrolaseprovided by HGNC Primary source HGNC:HGNC:6710 See related Ensembl:ENSG00000111144 MIM:151570; AllianceGenome:HGNC:6710 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues See more Orthologs mouse all
LTB, Official Symbol LTBprovided by HGNC Official Full Name lymphotoxin betaprovided by HGNC Primary source HGNC:HGNC:6711 See related Ensembl:ENSG00000227507 MIM:600978; AllianceGenome:HGNC:6711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p33; TNFC; TNFSF3; TNLG1C Summary Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 84.6), lymph node (RPKM 56.9) and 8 other tissues See more Orthologs mouse all
LTB4R, Official Symbol LTB4Rprovided by HGNC Official Full Name leukotriene B4 receptorprovided by HGNC Primary source HGNC:HGNC:6713 See related Ensembl:ENSG00000213903 MIM:601531; AllianceGenome:HGNC:6713 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLT1; BLTR; P2Y7; GPR16; LTBR1; P2RY7; CMKRL1; LTB4R1 Summary Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 33.9), esophagus (RPKM 9.6) and 10 other tissues See more Orthologs mouse all
LTB4R2, Official Symbol LTB4R2provided by HGNC Official Full Name leukotriene B4 receptor 2provided by HGNC Primary source HGNC:HGNC:19260 See related Ensembl:ENSG00000213906 MIM:605773; AllianceGenome:HGNC:19260 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLT2; NOP9; BLTR2; JULF2; KPG_004; LTB4-R2; LTB4-R 2 Summary Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 12.7), spleen (RPKM 9.3) and 21 other tissues See more Orthologs mouse all
LTBP1, Official Symbol LTBP1provided by HGNC Official Full Name latent transforming growth factor beta binding protein 1provided by HGNC Primary source HGNC:HGNC:6714 See related Ensembl:ENSG00000049323 MIM:150390; AllianceGenome:HGNC:6714 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARCL2E Summary The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 40.6), placenta (RPKM 32.5) and 24 other tissues See more Orthologs mouse all
LTBP2, Official Symbol LTBP2provided by HGNC Official Full Name latent transforming growth factor beta binding protein 2provided by HGNC Primary source HGNC:HGNC:6715 See related Ensembl:ENSG00000119681 MIM:602091; AllianceGenome:HGNC:6715 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WMS3; GLC3D; LTBP3; MSPKA; MSTP031; C14orf141 Summary The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008] Annotation information Note: The official symbol for this gene (GeneID: 4053) is now LTBP2. A different gene (GeneID: 4054) was previously identified in PMID: 7719025 as LTBP2. [27 Jan 2017] Expression Broad expression in lung (RPKM 30.6), ovary (RPKM 21.5) and 19 other tissues See more Orthologs mouse all
LTBP3, Official Symbol LTBP3provided by HGNC Official Full Name latent transforming growth factor beta binding protein 3provided by HGNC Primary source HGNC:HGNC:6716 See related Ensembl:ENSG00000168056 MIM:602090; AllianceGenome:HGNC:6716 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DASS; LTBP2; LTBP-3; STHAG6; pp6425; GPHYSD3 Summary The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] Annotation information Note: This gene (GeneID: 4054) was identified as LTBP2 in PMID: 7719025. The official symbol for this gene is now LTBP3. [27 Jan 2017] Expression Ubiquitous expression in ovary (RPKM 27.2), fat (RPKM 25.7) and 25 other tissues See more Orthologs mouse all
LTBP4, Official Symbol LTBP4provided by HGNC Official Full Name latent transforming growth factor beta binding protein 4provided by HGNC Primary source HGNC:HGNC:6717 See related Ensembl:ENSG00000090006 MIM:604710; AllianceGenome:HGNC:6717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARCL1C; LTBP-4; LTBP4L; LTBP4S Summary The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] Expression Broad expression in prostate (RPKM 61.4), endometrium (RPKM 53.8) and 22 other tissues See more Orthologs mouse all
LTBR, Official Symbol LTBRprovided by HGNC Official Full Name lymphotoxin beta receptorprovided by HGNC Primary source HGNC:HGNC:6718 See related Ensembl:ENSG00000111321 MIM:600979; AllianceGenome:HGNC:6718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III Summary This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in prostate (RPKM 23.4), placenta (RPKM 23.0) and 25 other tissues See more Orthologs mouse all
LTC4S, Official Symbol LTC4Sprovided by HGNC Official Full Name leukotriene C4 synthaseprovided by HGNC Primary source HGNC:HGNC:6719 See related Ensembl:ENSG00000213316 MIM:246530; AllianceGenome:HGNC:6719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 3.3), lung (RPKM 2.5) and 23 other tissues See more Orthologs mouse all
LTF, Official Symbol LTFprovided by HGNC Official Full Name lactotransferrinprovided by HGNC Primary source HGNC:HGNC:6720 See related Ensembl:ENSG00000012223 MIM:150210; AllianceGenome:HGNC:6720 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LF; HLF2; GIG12; HEL110 Summary This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Biased expression in bone marrow (RPKM 1214.2), salivary gland (RPKM 176.0) and 2 other tissues See more Orthologs mouse all
LTK, Official Symbol LTKprovided by HGNC Official Full Name leukocyte receptor tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:6721 See related Ensembl:ENSG00000062524 MIM:151520; AllianceGenome:HGNC:6721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TYK1 Summary The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] Expression Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues See more Orthologs mouse all
LTN1, Official Symbol LTN1provided by HGNC Official Full Name listerin E3 ubiquitin protein ligase 1provided by HGNC Primary source HGNC:HGNC:13082 See related Ensembl:ENSG00000198862 MIM:613083; AllianceGenome:HGNC:13082 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF160; ZNF294; C21orf10; C21orf98 Summary Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in thyroid (RPKM 7.5), placenta (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
LTO1, Official Symbol LTO1provided by HGNC Official Full Name LTO1 maturation factor of ABCE1provided by HGNC Primary source HGNC:HGNC:17589 See related Ensembl:ENSG00000149716 MIM:607224; AllianceGenome:HGNC:17589 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CIAB1; TAOS1; ORAOV1 Summary Involved in protein maturation by [4Fe-4S] cluster transfer; ribosomal large subunit biogenesis; and translational initiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.2), skin (RPKM 2.1) and 25 other tissues See more Orthologs mouse all
LTV1, Official Symbol LTV1provided by HGNC Official Full Name LTV1 ribosome biogenesis factorprovided by HGNC Primary source HGNC:HGNC:21173 See related Ensembl:ENSG00000135521 MIM:620074; AllianceGenome:HGNC:21173 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPHAK; C6orf93; dJ468K18.4 Summary Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 17.0), testis (RPKM 13.5) and 25 other tissues See more Orthologs mouse all
LTV1P1, Official Symbol LTV1P1provided by HGNC Official Full Name LTV1 ribosome biogenesis factor pseudogene 1provided by HGNC Primary source HGNC:HGNC:44049 See related Ensembl:ENSG00000250219 AllianceGenome:HGNC:44049 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LUADT1, Official Symbol LUADT1provided by HGNC Official Full Name lung adenocarcinoma associated transcript 1provided by HGNC Primary source HGNC:HGNC:51845 See related Ensembl:ENSG00000196634 AllianceGenome:HGNC:51845 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
LUARIS, Official Symbol LUARISprovided by HGNC Official Full Name lncRNA upregulator of antiviral response interferon signalingprovided by HGNC Primary source HGNC:HGNC:40992 See related Ensembl:ENSG00000231638 MIM:618172; AllianceGenome:HGNC:40992 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCAT6; lncRNA32 Expression Low expression observed in reference dataset See more
LUC7L, Official Symbol LUC7Lprovided by HGNC Official Full Name LUC7 likeprovided by HGNC Primary source HGNC:HGNC:6723 See related Ensembl:ENSG00000007392 MIM:607782; AllianceGenome:HGNC:6723 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Luc7; SR+89; LUC7B1; hLuc7B1 Summary The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in endometrium (RPKM 18.6), spleen (RPKM 15.0) and 25 other tissues See more Orthologs mouse all
LUC7L2, Official Symbol LUC7L2provided by HGNC Official Full Name LUC7 like 2, pre-mRNA splicing factorprovided by HGNC Primary source HGNC:HGNC:21608 See related Ensembl:ENSG00000146963 MIM:613056; AllianceGenome:HGNC:21608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-59; CGI-74; LUC7B2 Summary This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in thyroid (RPKM 34.6), bone marrow (RPKM 32.4) and 25 other tissues See more Orthologs mouse all
LUC7L3, Official Symbol LUC7L3provided by HGNC Official Full Name LUC7 like 3 pre-mRNA splicing factorprovided by HGNC Primary source HGNC:HGNC:24309 See related Ensembl:ENSG00000108848 MIM:609434; AllianceGenome:HGNC:24309 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRA; CROP; LUC7A; hLuc7A; CREAP-1; OA48-18 Summary This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009] Expression Ubiquitous expression in endometrium (RPKM 53.0), ovary (RPKM 46.4) and 25 other tissues See more Orthologs mouse all
LUCAT1, Official Symbol LUCAT1provided by HGNC Official Full Name lung cancer associated transcript 1provided by HGNC Primary source HGNC:HGNC:48498 See related Ensembl:ENSG00000248323 MIM:618190; AllianceGenome:HGNC:48498 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCAL1; SCAT5 Expression Biased expression in appendix (RPKM 2.5), bone marrow (RPKM 1.2) and 9 other tissues See more Orthologs mouse all
LUM, Official Symbol LUMprovided by HGNC Official Full Name lumicanprovided by HGNC Primary source HGNC:HGNC:6724 See related Ensembl:ENSG00000139329 MIM:600616; AllianceGenome:HGNC:6724 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LDC; SLRR2D Summary This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 981.2), urinary bladder (RPKM 643.2) and 14 other tissues See more Orthologs mouse all
LUNAR1, Official Symbol LUNAR1provided by HGNC Official Full Name leukemia-associated non-coding IGF1R activator RNA 1provided by HGNC Primary source HGNC:HGNC:51199 See related AllianceGenome:HGNC:51199 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is thought to produce a functional long non-coding RNA. It is regulated by Notch and is overexpressed in T cell acute lymphoblastic leukemia. The transcript acts as a positive regulator of cell division by promoting expression of the insulin-like growth factor type I receptor (IGF1R) gene. [provided by RefSeq, Feb 2015] Expression Low expression observed in reference dataset See more
LURAP1, Official Symbol LURAP1provided by HGNC Official Full Name leucine rich adaptor protein 1provided by HGNC Primary source HGNC:HGNC:32327 See related Ensembl:ENSG00000171357 MIM:616129; AllianceGenome:HGNC:32327 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRP35A; LRAP35a; C1orf190 Summary Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of cytokine production. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in thyroid (RPKM 5.9), testis (RPKM 4.8) and 20 other tissues See more Orthologs mouse all
LURAP1L, Official Symbol LURAP1Lprovided by HGNC Official Full Name leucine rich adaptor protein 1 likeprovided by HGNC Primary source HGNC:HGNC:31452 See related Ensembl:ENSG00000153714 MIM:616130; AllianceGenome:HGNC:31452 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRAP35b; bA3L8.2; C9orf150; HYST0841 Summary Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 9.1), lung (RPKM 7.8) and 23 other tissues See more Orthologs mouse all