psui3905/ncbi_genes_summary huggingface dataset:
TRAJ59, Official Symbol TRAJ59provided by HGNC Official Full Name T cell receptor alpha joining 59 (non-functional)provided by HGNC Primary source HGNC:HGNC:12091 See related Ensembl:ENSG00000211832 IMGT/GENE-DB:TRAJ59; AllianceGenome:HGNC:12091 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly
TRAJ6, Official Symbol TRAJ6provided by HGNC Official Full Name T cell receptor alpha joining 6provided by HGNC Primary source HGNC:HGNC:12092 See related Ensembl:ENSG00000211883 IMGT/GENE-DB:TRAJ6; AllianceGenome:HGNC:12092 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly
TRAJ60, Official Symbol TRAJ60provided by HGNC Official Full Name T cell receptor alpha joining 60 (pseudogene)provided by HGNC Primary source HGNC:HGNC:12093 See related Ensembl:ENSG00000249446 IMGT/GENE-DB:TRAJ60; AllianceGenome:HGNC:12093 Gene type pseudo RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCRA Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
TRAJ61, Official Symbol TRAJ61provided by HGNC Official Full Name T cell receptor alpha joining 61 (non-functional)provided by HGNC Primary source HGNC:HGNC:12094 See related Ensembl:ENSG00000211831 IMGT/GENE-DB:TRAJ61; AllianceGenome:HGNC:12094 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly
TRAJ7, Official Symbol TRAJ7provided by HGNC Official Full Name T cell receptor alpha joining 7provided by HGNC Primary source HGNC:HGNC:12095 See related Ensembl:ENSG00000211882 IMGT/GENE-DB:TRAJ7; AllianceGenome:HGNC:12095 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly
TRAJ8, Official Symbol TRAJ8provided by HGNC Official Full Name T cell receptor alpha joining 8provided by HGNC Primary source HGNC:HGNC:12096 See related Ensembl:ENSG00000211881 IMGT/GENE-DB:TRAJ8; AllianceGenome:HGNC:12096 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly
TRAJ9, Official Symbol TRAJ9provided by HGNC Official Full Name T cell receptor alpha joining 9provided by HGNC Primary source HGNC:HGNC:12097 See related Ensembl:ENSG00000211880 IMGT/GENE-DB:TRAJ9; AllianceGenome:HGNC:12097 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly
TRAK1, Official Symbol TRAK1provided by HGNC Official Full Name trafficking kinesin protein 1provided by HGNC Primary source HGNC:HGNC:29947 See related Ensembl:ENSG00000182606 MIM:608112; AllianceGenome:HGNC:29947 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE68; MILT1; EIEE68; OIP106 Summary Predicted to enable GABA receptor binding activity and myosin binding activity. Involved in endosome to lysosome transport. Located in early endosome and mitochondrion. Implicated in developmental and epileptic encephalopathy 68. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 17.5), stomach (RPKM 12.1) and 24 other tissues See more Orthologs mouse all
TRAK2, Official Symbol TRAK2provided by HGNC Official Full Name trafficking kinesin protein 2provided by HGNC Primary source HGNC:HGNC:13206 See related Ensembl:ENSG00000115993 MIM:607334; AllianceGenome:HGNC:13206 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRIF1; MILT2; OIP98; CALS-C; GRIF-1; ALS2CR3 Summary Predicted to enable GABA receptor binding activity and myosin binding activity. Predicted to be involved in several processes, including mitochondrion distribution; organelle transport along microtubule; and protein targeting. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 26.1), thyroid (RPKM 23.5) and 25 other tissues See more Orthologs mouse all
TRAM1, Official Symbol TRAM1provided by HGNC Official Full Name translocation associated membrane protein 1provided by HGNC Primary source HGNC:HGNC:20568 See related Ensembl:ENSG00000067167 MIM:605190; AllianceGenome:HGNC:20568 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRAM; PNAS8; TRAMP Summary This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues See more Orthologs mouse all
TRAM1L1, Official Symbol TRAM1L1provided by HGNC Official Full Name translocation associated membrane protein 1 like 1provided by HGNC Primary source HGNC:HGNC:28371 See related Ensembl:ENSG00000174599 MIM:617505; AllianceGenome:HGNC:28371 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in protein insertion into ER membrane. Predicted to be integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
TRAM2, Official Symbol TRAM2provided by HGNC Official Full Name translocation associated membrane protein 2provided by HGNC Primary source HGNC:HGNC:16855 See related Ensembl:ENSG00000065308 MIM:608485; AllianceGenome:HGNC:16855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004] Expression Broad expression in placenta (RPKM 12.1), testis (RPKM 6.9) and 23 other tissues See more Orthologs mouse all
TRAM2-AS1, Official Symbol TRAM2-AS1provided by HGNC Official Full Name TRAM2 antisense RNA 1 (head to head)provided by HGNC Primary source HGNC:HGNC:48663 See related Ensembl:ENSG00000225791 AllianceGenome:HGNC:48663 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in thyroid (RPKM 4.4), kidney (RPKM 3.4) and 25 other tissues See more
TRANK1, Official Symbol TRANK1provided by HGNC Official Full Name tetratricopeptide repeat and ankyrin repeat containing 1provided by HGNC Primary source HGNC:HGNC:29011 See related Ensembl:ENSG00000168016 MIM:619316; AllianceGenome:HGNC:29011 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LBA1 Summary Predicted to enable ATP binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 7.0), lymph node (RPKM 6.9) and 24 other tissues See more Orthologs mouse all
TRAP1, Official Symbol TRAP1provided by HGNC Official Full Name TNF receptor associated protein 1provided by HGNC Primary source HGNC:HGNC:16264 See related Ensembl:ENSG00000126602 MIM:606219; AllianceGenome:HGNC:16264 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSP75; HSP 75; HSP90L; TRAP-1 Summary This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues See more Orthologs mouse all
TRAPPC1, Official Symbol TRAPPC1provided by HGNC Official Full Name trafficking protein particle complex subunit 1provided by HGNC Primary source HGNC:HGNC:19894 See related Ensembl:ENSG00000170043 MIM:610969; AllianceGenome:HGNC:19894 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BET5; MUM2 Summary This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] Expression Ubiquitous expression in placenta (RPKM 52.2), lymph node (RPKM 50.3) and 25 other tissues See more Orthologs mouse all
TRAPPC10, Official Symbol TRAPPC10provided by HGNC Official Full Name trafficking protein particle complex subunit 10provided by HGNC Primary source HGNC:HGNC:11868 See related Ensembl:ENSG00000160218 MIM:602103; AllianceGenome:HGNC:11868 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EHOC1; GT334; TMEM1; TRS30; EHOC-1; TRS130; NEDMISS Summary The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 11.9), lymph node (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
TRAPPC11, Official Symbol TRAPPC11provided by HGNC Official Full Name trafficking protein particle complex subunit 11provided by HGNC Primary source HGNC:HGNC:25751 See related Ensembl:ENSG00000168538 MIM:614138; AllianceGenome:HGNC:25751 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRY; FOIGR; LGMD2S; C4orf41; LGMDR18 Summary The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in adrenal (RPKM 9.6), thyroid (RPKM 9.5) and 25 other tissues See more Orthologs mouse all
TRAPPC12, Official Symbol TRAPPC12provided by HGNC Official Full Name trafficking protein particle complex subunit 12provided by HGNC Primary source HGNC:HGNC:24284 See related Ensembl:ENSG00000171853 MIM:614139; AllianceGenome:HGNC:24284 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PEBAS; TTC15; CGI-87; TTC-15 Summary Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of TRAPP complex. Colocalizes with endoplasmic reticulum-Golgi intermediate compartment and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.2), brain (RPKM 2.7) and 25 other tissues See more Orthologs mouse all
TRAPPC12-AS1, Official Symbol TRAPPC12-AS1provided by HGNC Official Full Name TRAPPC12 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41046 See related AllianceGenome:HGNC:41046 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TRAPPC13, Official Symbol TRAPPC13provided by HGNC Official Full Name trafficking protein particle complex subunit 13provided by HGNC Primary source HGNC:HGNC:25828 See related Ensembl:ENSG00000113597 AllianceGenome:HGNC:25828 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SHLD3; C5orf44 Summary Predicted to be located in cytosol. Predicted to be part of TRAPPIII protein complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 7.6), thyroid (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
TRAPPC13P1, Official Symbol TRAPPC13P1provided by HGNC Official Full Name trafficking protein particle complex 13 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50347 See related Ensembl:ENSG00000235447 AllianceGenome:HGNC:50347 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TRAPPC14, Official Symbol TRAPPC14provided by HGNC Official Full Name trafficking protein particle complex subunit 14provided by HGNC Primary source HGNC:HGNC:25604 See related Ensembl:ENSG00000146826 MIM:618350; AllianceGenome:HGNC:25604 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAP11; MCPH25; C7orf43 Summary Enables alpha-tubulin binding activity. Involved in cilium assembly and regulation of cell population proliferation. Located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Part of TRAPPII protein complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 16.4), spleen (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
TRAPPC2, Official Symbol TRAPPC2provided by HGNC Official Full Name trafficking protein particle complex subunit 2provided by HGNC Primary source HGNC:HGNC:23068 See related Ensembl:ENSG00000196459 MIM:300202; AllianceGenome:HGNC:23068 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEDL; SEDT; MIP2A; TRS20; ZNF547L; hYP38334; TRAPPC2P1 Summary The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in lymph node (RPKM 4.2), brain (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
TRAPPC2B, Official Symbol TRAPPC2Bprovided by HGNC Official Full Name trafficking protein particle complex subunit 2Bprovided by HGNC Primary source HGNC:HGNC:10710 See related Ensembl:ENSG00000256060 MIM:620472; AllianceGenome:HGNC:10710 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIP2A; SEDLP; MIP-2A; SEDLP1; TRAPPC2P1 Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 7.7), adrenal (RPKM 7.1) and 25 other tissues See more Orthologs all
TRAPPC2L, Official Symbol TRAPPC2Lprovided by HGNC Official Full Name trafficking protein particle complex subunit 2Lprovided by HGNC Primary source HGNC:HGNC:30887 See related Ensembl:ENSG00000167515 MIM:610970; AllianceGenome:HGNC:30887 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PERRB; HSPC176 Summary This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in adrenal (RPKM 16.3), testis (RPKM 13.9) and 25 other tissues See more Orthologs mouse all
TRAPPC2LP1, Official Symbol TRAPPC2LP1provided by HGNC Official Full Name TRAPPC2L pseudogene 1provided by HGNC Primary source HGNC:HGNC:54982 See related Ensembl:ENSG00000231053 AllianceGenome:HGNC:54982 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TRAPPC3, Official Symbol TRAPPC3provided by HGNC Official Full Name trafficking protein particle complex subunit 3provided by HGNC Primary source HGNC:HGNC:19942 See related Ensembl:ENSG00000054116 MIM:610955; AllianceGenome:HGNC:19942 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BET3 Summary This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in thyroid (RPKM 23.9), adrenal (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
TRAPPC3L, Official Symbol TRAPPC3Lprovided by HGNC Official Full Name trafficking protein particle complex subunit 3Lprovided by HGNC Primary source HGNC:HGNC:21090 See related Ensembl:ENSG00000173626 MIM:614137; AllianceGenome:HGNC:21090 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BET3L; bA259P20.2 Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in spleen (RPKM 1.6), placenta (RPKM 1.5) and 5 other tissues See more Orthologs mouse all
TRAPPC4, Official Symbol TRAPPC4provided by HGNC Official Full Name trafficking protein particle complex subunit 4provided by HGNC Primary source HGNC:HGNC:19943 See related Ensembl:ENSG00000196655 MIM:610971; AllianceGenome:HGNC:19943 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SBDN; TRS23; PTD009; CGI-104; HSPC172; NEDESBA; SYNBINDIN Summary Involved in autophagy and endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 25.2), adrenal (RPKM 22.1) and 25 other tissues See more Orthologs mouse all
TRAPPC5, Official Symbol TRAPPC5provided by HGNC Official Full Name trafficking protein particle complex subunit 5provided by HGNC Primary source HGNC:HGNC:23067 See related Ensembl:ENSG00000181029 AllianceGenome:HGNC:23067 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRS31 Summary Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 17.0), kidney (RPKM 16.1) and 25 other tissues See more Orthologs mouse all
TRAPPC6A, Official Symbol TRAPPC6Aprovided by HGNC Official Full Name trafficking protein particle complex subunit 6Aprovided by HGNC Primary source HGNC:HGNC:23069 See related Ensembl:ENSG00000007255 MIM:610396; AllianceGenome:HGNC:23069 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRS33 Summary This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in kidney (RPKM 18.2), spleen (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
TRAPPC6B, Official Symbol TRAPPC6Bprovided by HGNC Official Full Name trafficking protein particle complex subunit 6Bprovided by HGNC Primary source HGNC:HGNC:23066 See related Ensembl:ENSG00000182400 MIM:610397; AllianceGenome:HGNC:23066 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPC6; NEDMEBA Summary TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in brain (RPKM 16.1), thyroid (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
TRAPPC8, Official Symbol TRAPPC8provided by HGNC Official Full Name trafficking protein particle complex subunit 8provided by HGNC Primary source HGNC:HGNC:29169 See related Ensembl:ENSG00000153339 MIM:614136; AllianceGenome:HGNC:29169 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GSG1; TRS85; HsT2706; KIAA1012 Summary Involved in Golgi organization. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 23.5), thyroid (RPKM 10.8) and 25 other tissues See more Orthologs mouse all
TRAPPC9, Official Symbol TRAPPC9provided by HGNC Official Full Name trafficking protein particle complex subunit 9provided by HGNC Primary source HGNC:HGNC:30832 See related Ensembl:ENSG00000167632 MIM:611966; AllianceGenome:HGNC:30832 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T1; IBP; NIBP; MRT13; TRS120; IKBKBBP Summary This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive cognitive disability. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] Expression Ubiquitous expression in brain (RPKM 3.1), thyroid (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
TRARG1, Official Symbol TRARG1provided by HGNC Official Full Name trafficking regulator of GLUT4 (SLC2A4) 1provided by HGNC Primary source HGNC:HGNC:29592 See related Ensembl:ENSG00000184811 MIM:612211; AllianceGenome:HGNC:29592 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BEC-1; DSPB1; LOST1; TUSC5; IFITMD3 Summary Predicted to be involved in endosome to plasma membrane protein transport and glucose import in response to insulin stimulus. Predicted to act upstream of or within vesicle fusion to plasma membrane. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward fat (RPKM 61.1) See more Orthologs mouse all
TRAT1, Official Symbol TRAT1provided by HGNC Official Full Name T cell receptor associated transmembrane adaptor 1provided by HGNC Primary source HGNC:HGNC:30698 See related Ensembl:ENSG00000163519 MIM:604962; AllianceGenome:HGNC:30698 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIM; TCRIM; HSPC062; pp29/30 Summary Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 11.9), appendix (RPKM 6.4) and 9 other tissues See more Orthologs mouse all
TRAV1-1, Official Symbol TRAV1-1provided by HGNC Official Full Name T cell receptor alpha variable 1-1provided by HGNC Primary source HGNC:HGNC:12101 See related Ensembl:ENSG00000255569 IMGT/GENE-DB:TRAV1-1; AllianceGenome:HGNC:12101 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRAV11; TCRAV1S1; TCRAV7S1 Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly
TRAV1-2, Official Symbol TRAV1-2provided by HGNC Official Full Name T cell receptor alpha variable 1-2provided by HGNC Primary source HGNC:HGNC:12102 See related Ensembl:ENSG00000256553 IMGT/GENE-DB:TRAV1-2; AllianceGenome:HGNC:12102 Gene type other RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRAV12; TCRAV1S2; TCRAV7S2 Summary T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016] Annotation information Annotation category: partial on reference assembly