psui3905/ncbi_genes_summary huggingface dataset:
RAD54B, Official Symbol RAD54Bprovided by HGNC Official Full Name RAD54 homolog Bprovided by HGNC Primary source HGNC:HGNC:17228 See related Ensembl:ENSG00000197275 MIM:604289; AllianceGenome:HGNC:17228 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDH54 Summary The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 1.8), prostate (RPKM 1.3) and 25 other tissues See more Orthologs mouse all
RAD54L, Official Symbol RAD54Lprovided by HGNC Official Full Name RAD54 likeprovided by HGNC Primary source HGNC:HGNC:9826 See related Ensembl:ENSG00000085999 MIM:603615; AllianceGenome:HGNC:9826 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HR54; hHR54; RAD54A; hRAD54 Summary The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008] Expression Broad expression in testis (RPKM 5.9), lymph node (RPKM 2.7) and 15 other tissues See more Orthologs mouse all
RAD54L2, Official Symbol RAD54L2provided by HGNC Official Full Name RAD54 like 2provided by HGNC Primary source HGNC:HGNC:29123 See related Ensembl:ENSG00000164080 MIM:620006; AllianceGenome:HGNC:29123 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARIP4; HSPC325; SRISNF2L Summary Predicted to enable ATP hydrolysis activity; protein kinase binding activity; and transcription coregulator activity. Predicted to be involved in DNA duplex unwinding. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 3.3), spleen (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
RAD54L2P1, Official Symbol RAD54L2P1provided by HGNC Official Full Name RAD54L2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54570 See related Ensembl:ENSG00000269316 AllianceGenome:HGNC:54570 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RAD9A, Official Symbol RAD9Aprovided by HGNC Official Full Name RAD9 checkpoint clamp component Aprovided by HGNC Primary source HGNC:HGNC:9827 See related Ensembl:ENSG00000172613 MIM:603761; AllianceGenome:HGNC:9827 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAD9 Summary This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in spleen (RPKM 9.1), skin (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
RAD9B, Official Symbol RAD9Bprovided by HGNC Official Full Name RAD9 checkpoint clamp component Bprovided by HGNC Primary source HGNC:HGNC:21700 See related Ensembl:ENSG00000151164 MIM:608368; AllianceGenome:HGNC:21700 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 7.5), bone marrow (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
RADIL, Official Symbol RADILprovided by HGNC Official Full Name Rap associating with DIL domainprovided by HGNC Primary source HGNC:HGNC:22226 See related Ensembl:ENSG00000157927 MIM:611491; AllianceGenome:HGNC:22226 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RASIP2 Summary Predicted to enable GTPase binding activity. Acts upstream of or within substrate adhesion-dependent cell spreading. Located in microtubule. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 4.1), lung (RPKM 1.4) and 10 other tissues See more Orthologs mouse all
RADX, Official Symbol RADXprovided by HGNC Official Full Name RPA1 related single stranded DNA binding protein, X-linkedprovided by HGNC Primary source HGNC:HGNC:25486 See related Ensembl:ENSG00000147231 AllianceGenome:HGNC:25486 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXorf57 Summary Enables single-stranded DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in nuclear speck and replication fork. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in adrenal (RPKM 4.5), ovary (RPKM 4.0) and 24 other tissues See more Orthologs mouse all
RAE1, Official Symbol RAE1provided by HGNC Official Full Name ribonucleic acid export 1provided by HGNC Primary source HGNC:HGNC:9828 See related Ensembl:ENSG00000101146 MIM:603343; AllianceGenome:HGNC:9828 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gle2; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1 Summary Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 35.7), bone marrow (RPKM 13.2) and 24 other tissues See more Orthologs mouse all
RAET1E, Official Symbol RAET1Eprovided by HGNC Official Full Name retinoic acid early transcript 1Eprovided by HGNC Primary source HGNC:HGNC:16793 See related Ensembl:ENSG00000164520 MIM:609243; AllianceGenome:HGNC:16793 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7 Summary This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] Expression Biased expression in esophagus (RPKM 7.0) and skin (RPKM 2.7) See more Orthologs all
RAET1G, Official Symbol RAET1Gprovided by HGNC Official Full Name retinoic acid early transcript 1Gprovided by HGNC Primary source HGNC:HGNC:16795 See related Ensembl:ENSG00000203722 MIM:609244; AllianceGenome:HGNC:16795 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ULBP5 Summary This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015] Expression Biased expression in esophagus (RPKM 1.3), adrenal (RPKM 0.9) and 11 other tissues See more Orthologs all
RAET1L, Official Symbol RAET1Lprovided by HGNC Official Full Name retinoic acid early transcript 1Lprovided by HGNC Primary source HGNC:HGNC:16798 See related Ensembl:ENSG00000155918 MIM:611047; AllianceGenome:HGNC:16798 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ULBP6; RAET1H Summary RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008] Expression Biased expression in esophagus (RPKM 15.6) and skin (RPKM 1.0) See more
RAET1M, Official Symbol RAET1Mprovided by HGNC Official Full Name retinoic acid early transcript 1M (pseudogene)provided by HGNC Primary source HGNC:HGNC:16799 See related Ensembl:ENSG00000216444 AllianceGenome:HGNC:16799 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RAF1, Official Symbol RAF1provided by HGNC Official Full Name Raf-1 proto-oncogene, serine/threonine kinaseprovided by HGNC Primary source HGNC:HGNC:9829 See related Ensembl:ENSG00000132155 MIM:164760; AllianceGenome:HGNC:9829 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NS5; CRAF; Raf-1; c-Raf; CMD1NN Summary This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 34.4), heart (RPKM 32.5) and 25 other tissues See more Orthologs mouse all
RAF1P1, Official Symbol RAF1P1provided by HGNC Official Full Name RAF1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:9830 See related Ensembl:ENSG00000250040 AllianceGenome:HGNC:9830 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RAG1, Official Symbol RAG1provided by HGNC Official Full Name recombination activating 1provided by HGNC Primary source HGNC:HGNC:9831 See related Ensembl:ENSG00000166349 MIM:179615; AllianceGenome:HGNC:9831 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAG-1; RNF74 Summary The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 2.3), bone marrow (RPKM 1.9) and 20 other tissues See more Orthologs mouse all
RAG2, Official Symbol RAG2provided by HGNC Official Full Name recombination activating 2provided by HGNC Primary source HGNC:HGNC:9832 See related Ensembl:ENSG00000175097 MIM:179616; AllianceGenome:HGNC:9832 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAG-2 Summary This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008] Expression Restricted expression toward thyroid (RPKM 16.6) See more Orthologs mouse all
RAI1, Official Symbol RAI1provided by HGNC Official Full Name retinoic acid induced 1provided by HGNC Primary source HGNC:HGNC:9834 See related Ensembl:ENSG00000108557 MIM:607642; AllianceGenome:HGNC:9834 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMS; SMCR Summary This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 5.1), endometrium (RPKM 4.9) and 25 other tissues See more Orthologs mouse all
RAI1-AS1, Official Symbol RAI1-AS1provided by HGNC Official Full Name RAI1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40496 See related Ensembl:ENSG00000237328 AllianceGenome:HGNC:40496 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
RAI14, Official Symbol RAI14provided by HGNC Official Full Name retinoic acid induced 14provided by HGNC Primary source HGNC:HGNC:14873 See related Ensembl:ENSG00000039560 MIM:606586; AllianceGenome:HGNC:14873 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAI13; NORPEG Summary Predicted to enable actin binding activity. Predicted to be involved in several processes, including apoptotic signaling pathway; regulation of NIK/NF-kappaB signaling; and spermatogenesis. Located in cytosol; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in endometrium (RPKM 27.5), placenta (RPKM 14.1) and 23 other tissues See more Orthologs mouse all
RAI2, Official Symbol RAI2provided by HGNC Official Full Name retinoic acid induced 2provided by HGNC Primary source HGNC:HGNC:9835 See related Ensembl:ENSG00000131831 MIM:300217; AllianceGenome:HGNC:9835 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] Expression Ubiquitous expression in endometrium (RPKM 19.5), ovary (RPKM 15.2) and 23 other tissues See more Orthologs mouse all
RALA, Official Symbol RALAprovided by HGNC Official Full Name RAS like proto-oncogene Aprovided by HGNC Primary source HGNC:HGNC:9839 See related Ensembl:ENSG00000006451 MIM:179550; AllianceGenome:HGNC:9839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAL; HINCONS Summary The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 22.0), lung (RPKM 20.7) and 25 other tissues See more Orthologs mouse all
RALB, Official Symbol RALBprovided by HGNC Official Full Name RAS like proto-oncogene Bprovided by HGNC Primary source HGNC:HGNC:9840 See related Ensembl:ENSG00000144118 MIM:179551; AllianceGenome:HGNC:9840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 28.5), appendix (RPKM 25.0) and 25 other tissues See more Orthologs mouse all
RALBP1, Official Symbol RALBP1provided by HGNC Official Full Name ralA binding protein 1provided by HGNC Primary source HGNC:HGNC:9841 See related Ensembl:ENSG00000017797 MIM:605801; AllianceGenome:HGNC:9841 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIP1; RLIP1; RLIP76 Summary RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in kidney (RPKM 28.4), skin (RPKM 27.5) and 25 other tissues See more Orthologs mouse all
RALBP1P1, Official Symbol RALBP1P1provided by HGNC Official Full Name RALBP1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54696 See related Ensembl:ENSG00000239880 AllianceGenome:HGNC:54696 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RALGAPA1, Official Symbol RALGAPA1provided by HGNC Official Full Name Ral GTPase activating protein catalytic subunit alpha 1provided by HGNC Primary source HGNC:HGNC:17770 See related Ensembl:ENSG00000174373 MIM:608884; AllianceGenome:HGNC:17770 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p240; GRIPE; GARNL1; TULIP1; NEDHRIT; RalGAPalpha1 Summary This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016] Expression Ubiquitous expression in brain (RPKM 5.4), thyroid (RPKM 5.2) and 25 other tissues See more Orthologs mouse all
RALGAPA1P1, Official Symbol RALGAPA1P1provided by HGNC Official Full Name RALGAPA1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:23203 See related Ensembl:ENSG00000229419 AllianceGenome:HGNC:23203 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GARNL2; GARNL2P; RALGAPA1P; bA235C23.1
RALGAPA2, Official Symbol RALGAPA2provided by HGNC Official Full Name Ral GTPase activating protein catalytic subunit alpha 2provided by HGNC Primary source HGNC:HGNC:16207 See related Ensembl:ENSG00000188559 MIM:618836; AllianceGenome:HGNC:16207 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p220; AS250; C20orf74; dJ1049G11; bA287B20.1; dJ1049G11.4 Summary Predicted to enable GTPase activator activity and protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 9.1), placenta (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
RALGAPB, Official Symbol RALGAPBprovided by HGNC Official Full Name Ral GTPase activating protein non-catalytic subunit betaprovided by HGNC Primary source HGNC:HGNC:29221 See related Ensembl:ENSG00000170471 MIM:618833; AllianceGenome:HGNC:29221 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA1219; RalGAPbeta Summary Enables protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 11.6), testis (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
RALGDS, Official Symbol RALGDSprovided by HGNC Official Full Name ral guanine nucleotide dissociation stimulatorprovided by HGNC Primary source HGNC:HGNC:9842 See related Ensembl:ENSG00000160271 MIM:601619; AllianceGenome:HGNC:9842 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGF; RGDS; RalGEF Summary Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in skin (RPKM 22.8), gall bladder (RPKM 22.0) and 25 other tissues See more Orthologs mouse all
RALGPS1, Official Symbol RALGPS1provided by HGNC Official Full Name Ral GEF with PH domain and SH3 binding motif 1provided by HGNC Primary source HGNC:HGNC:16851 See related Ensembl:ENSG00000136828 MIM:614444; AllianceGenome:HGNC:16851 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RALGEF2; RALGPS1A Summary Enables guanyl-nucleotide exchange factor activity. Involved in regulation of Ral protein signal transduction. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in small intestine (RPKM 6.1), duodenum (RPKM 5.9) and 24 other tissues See more Orthologs mouse all
RALGPS2, Official Symbol RALGPS2provided by HGNC Official Full Name Ral GEF with PH domain and SH3 binding motif 2provided by HGNC Primary source HGNC:HGNC:30279 See related Ensembl:ENSG00000116191 MIM:617819; AllianceGenome:HGNC:30279 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ595C2.1 Summary Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction; regulation of catalytic activity; and small GTPase mediated signal transduction. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 23.5), lymph node (RPKM 18.8) and 22 other tissues See more Orthologs mouse all
RALY, Official Symbol RALYprovided by HGNC Official Full Name RALY heterogeneous nuclear ribonucleoproteinprovided by HGNC Primary source HGNC:HGNC:15921 See related Ensembl:ENSG00000125970 MIM:614663; AllianceGenome:HGNC:15921 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P542; HNRPCL2 Summary This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in bone marrow (RPKM 18.7), testis (RPKM 18.3) and 25 other tissues See more Orthologs mouse all
RALY-AS1, Official Symbol RALY-AS1provided by HGNC Official Full Name RALY antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50743 See related Ensembl:ENSG00000285230 AllianceGenome:HGNC:50743 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 3.8), thyroid (RPKM 1.6) and 25 other tissues See more
RALYL, Official Symbol RALYLprovided by HGNC Official Full Name RALY RNA binding protein likeprovided by HGNC Primary source HGNC:HGNC:27036 See related Ensembl:ENSG00000184672 MIM:614648; AllianceGenome:HGNC:27036 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNRPCL3 Summary Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 3.1), adrenal (RPKM 2.1) and 3 other tissues See more Orthologs mouse all
RAMAC, Official Symbol RAMACprovided by HGNC Official Full Name RNA guanine-7 methyltransferase activating subunitprovided by HGNC Primary source HGNC:HGNC:31022 See related Ensembl:ENSG00000169612 MIM:614547; AllianceGenome:HGNC:31022 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAM; RAMMET; C15orf18; FAM103A1; HsT19360 Summary Enables RNA binding activity and enzyme activator activity. Involved in methylation and recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. Located in nucleoplasm. Part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 19.2), colon (RPKM 16.4) and 25 other tissues See more Orthologs mouse all
RAMACL, Official Symbol RAMACLprovided by HGNC Official Full Name RNA guanine-7 methyltransferase activating subunit likeprovided by HGNC Primary source HGNC:HGNC:21234 See related Ensembl:ENSG00000235272 AllianceGenome:HGNC:21234 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAMMETL; C6orf119; RAMMETP1; FAM103A2P; dJ427A4.2 Summary Predicted to enable RNA binding activity. Predicted to be involved in methylation and recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. Predicted to be part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
RAMP1, Official Symbol RAMP1provided by HGNC Official Full Name receptor activity modifying protein 1provided by HGNC Primary source HGNC:HGNC:9843 See related Ensembl:ENSG00000132329 MIM:605153; AllianceGenome:HGNC:9843 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] Expression Biased expression in endometrium (RPKM 26.3), prostate (RPKM 10.7) and 13 other tissues See more Orthologs mouse all
RAMP2, Official Symbol RAMP2provided by HGNC Official Full Name receptor activity modifying protein 2provided by HGNC Primary source HGNC:HGNC:9844 See related Ensembl:ENSG00000131477 MIM:605154; AllianceGenome:HGNC:9844 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 58.9), fat (RPKM 57.7) and 22 other tissues See more Orthologs mouse all
RAMP2-AS1, Official Symbol RAMP2-AS1provided by HGNC Official Full Name RAMP2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44358 See related Ensembl:ENSG00000197291 AllianceGenome:HGNC:44358 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in fat (RPKM 4.8), lung (RPKM 1.1) and 18 other tissues See more
RAMP3, Official Symbol RAMP3provided by HGNC Official Full Name receptor activity modifying protein 3provided by HGNC Primary source HGNC:HGNC:9845 See related Ensembl:ENSG00000122679 MIM:605155; AllianceGenome:HGNC:9845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 28.4), lymph node (RPKM 13.1) and 20 other tissues See more Orthologs mouse all
RAN, Official Symbol RANprovided by HGNC Official Full Name RAN, member RAS oncogene familyprovided by HGNC Primary source HGNC:HGNC:9846 See related Ensembl:ENSG00000132341 MIM:601179; AllianceGenome:HGNC:9846 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TC4; Gsp1; ARA24 Summary RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 71.4), testis (RPKM 70.1) and 25 other tissues See more Orthologs mouse all
RANBP1, Official Symbol RANBP1provided by HGNC Official Full Name RAN binding protein 1provided by HGNC Primary source HGNC:HGNC:9847 See related Ensembl:ENSG00000099901 MIM:601180; AllianceGenome:HGNC:9847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTF9A Summary This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 10.2) and 25 other tissues See more Orthologs mouse all
RANBP10, Official Symbol RANBP10provided by HGNC Official Full Name RAN binding protein 10provided by HGNC Primary source HGNC:HGNC:29285 See related Ensembl:ENSG00000141084 MIM:614031; AllianceGenome:HGNC:29285 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in bone marrow (RPKM 13.1), endometrium (RPKM 6.2) and 25 other tissues See more Orthologs mouse all
RANBP17, Official Symbol RANBP17provided by HGNC Official Full Name RAN binding protein 17provided by HGNC Primary source HGNC:HGNC:14428 See related Ensembl:ENSG00000204764 MIM:606141; AllianceGenome:HGNC:14428 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002] Expression Broad expression in testis (RPKM 1.6), thyroid (RPKM 0.5) and 15 other tissues See more Orthologs mouse all
RANBP2, Official Symbol RANBP2provided by HGNC Official Full Name RAN binding protein 2provided by HGNC Primary source HGNC:HGNC:9848 See related Ensembl:ENSG00000153201 MIM:601181; AllianceGenome:HGNC:9848 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358 Summary RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Ubiquitous expression in testis (RPKM 18.7), thyroid (RPKM 17.9) and 25 other tissues See more Orthologs all
RANBP3, Official Symbol RANBP3provided by HGNC Official Full Name RAN binding protein 3provided by HGNC Primary source HGNC:HGNC:9850 See related Ensembl:ENSG00000031823 MIM:603327; AllianceGenome:HGNC:9850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.0), lung (RPKM 13.0) and 25 other tissues See more Orthologs mouse all
RANBP3-DT, Official Symbol RANBP3-DTprovided by HGNC Official Full Name RANBP3 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55312 See related Ensembl:ENSG00000266983 AllianceGenome:HGNC:55312 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
RANBP3L, Official Symbol RANBP3Lprovided by HGNC Official Full Name RAN binding protein 3 likeprovided by HGNC Primary source HGNC:HGNC:26353 See related Ensembl:ENSG00000164188 MIM:616391; AllianceGenome:HGNC:26353 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables SMAD binding activity. Predicted to be involved in several processes, including mesenchymal cell differentiation involved in bone development; negative regulation of osteoblast differentiation; and positive regulation of myoblast differentiation. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 8.6), kidney (RPKM 8.4) and 11 other tissues See more Orthologs mouse all