psui3905/ncbi_genes_summary huggingface dataset:
ARFGEF3, Official Symbol ARFGEF3provided by HGNC Official Full Name ARFGEF family member 3provided by HGNC Primary source HGNC:HGNC:21213 See related Ensembl:ENSG00000112379 MIM:617411; AllianceGenome:HGNC:21213 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIG3; A7322; C6orf92; PPP1R33; KIAA1244; dJ171N11.1 Summary Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in transport vesicle membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 10.4), prostate (RPKM 8.3) and 15 other tissues See more Orthologs mouse all
ARFIP1, Official Symbol ARFIP1provided by HGNC Official Full Name ADP ribosylation factor interacting protein 1provided by HGNC Primary source HGNC:HGNC:21496 See related Ensembl:ENSG00000164144 MIM:605928; AllianceGenome:HGNC:21496 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSU52521 Summary Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 8.9), colon (RPKM 8.5) and 25 other tissues See more Orthologs mouse all
ARFIP2, Official Symbol ARFIP2provided by HGNC Official Full Name ADP ribosylation factor interacting protein 2provided by HGNC Primary source HGNC:HGNC:17160 See related Ensembl:ENSG00000132254 MIM:601638; AllianceGenome:HGNC:17160 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POR1 Summary Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization. Located in cell cortex; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 12.1), thyroid (RPKM 9.1) and 25 other tissues See more Orthologs mouse all
ARFRP1, Official Symbol ARFRP1provided by HGNC Official Full Name ADP ribosylation factor related protein 1provided by HGNC Primary source HGNC:HGNC:662 See related Ensembl:ENSG00000101246 MIM:604699; AllianceGenome:HGNC:662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARP; Arp1; ARL18 Summary The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012] Expression Ubiquitous expression in spleen (RPKM 7.0), fat (RPKM 5.7) and 25 other tissues See more Orthologs mouse all
ARG1, Official Symbol ARG1provided by HGNC Official Full Name arginase 1provided by HGNC Primary source HGNC:HGNC:663 See related Ensembl:ENSG00000118520 MIM:608313; AllianceGenome:HGNC:663 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Biased expression in liver (RPKM 237.4), bone marrow (RPKM 81.9) and 1 other tissue See more Orthologs mouse all
ARG2, Official Symbol ARG2provided by HGNC Official Full Name arginase 2provided by HGNC Primary source HGNC:HGNC:664 See related Ensembl:ENSG00000081181 MIM:107830; AllianceGenome:HGNC:664 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 94.3), prostate (RPKM 64.4) and 23 other tissues See more Orthologs mouse all
ARGFX, Official Symbol ARGFXprovided by HGNC Official Full Name arginine-fifty homeoboxprovided by HGNC Primary source HGNC:HGNC:30146 See related Ensembl:ENSG00000186103 MIM:611164; AllianceGenome:HGNC:30146 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
ARGLU1, Official Symbol ARGLU1provided by HGNC Official Full Name arginine and glutamate rich 1provided by HGNC Primary source HGNC:HGNC:25482 See related Ensembl:ENSG00000134884 MIM:614046; AllianceGenome:HGNC:25482 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables cadherin binding activity. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lung (RPKM 83.2), spleen (RPKM 81.9) and 25 other tissues See more Orthologs mouse all
ARHGAP1, Official Symbol ARHGAP1provided by HGNC Official Full Name Rho GTPase activating protein 1provided by HGNC Primary source HGNC:HGNC:673 See related Ensembl:ENSG00000175220 MIM:602732; AllianceGenome:HGNC:673 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHOGAP; RHOGAP1; CDC42GAP; p50rhoGAP Summary This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in urinary bladder (RPKM 39.6), heart (RPKM 37.9) and 25 other tissues See more Orthologs mouse all
ARHGAP10, Official Symbol ARHGAP10provided by HGNC Official Full Name Rho GTPase activating protein 10provided by HGNC Primary source HGNC:HGNC:26099 See related Ensembl:ENSG00000071205 MIM:609746; AllianceGenome:HGNC:26099 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRAF2; PSGAP; PS-GAP Summary Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 17.3), ovary (RPKM 10.9) and 23 other tissues See more Orthologs mouse all
ARHGAP11A, Official Symbol ARHGAP11Aprovided by HGNC Official Full Name Rho GTPase activating protein 11Aprovided by HGNC Primary source HGNC:HGNC:15783 See related Ensembl:ENSG00000198826 MIM:610589; AllianceGenome:HGNC:15783 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAP (1-12) Summary This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019] Expression Broad expression in bone marrow (RPKM 5.9), lymph node (RPKM 5.7) and 19 other tissues See more Orthologs mouse all
ARHGAP11B, Official Symbol ARHGAP11Bprovided by HGNC Official Full Name Rho GTPase activating protein 11Bprovided by HGNC Primary source HGNC:HGNC:15782 See related Ensembl:ENSG00000285077 MIM:616310; AllianceGenome:HGNC:15782 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B'-T; FAM7B1; GAP (1-8) Summary Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 7.6), lymph node (RPKM 4.9) and 16 other tissues See more Orthologs all
ARHGAP12, Official Symbol ARHGAP12provided by HGNC Official Full Name Rho GTPase activating protein 12provided by HGNC Primary source HGNC:HGNC:16348 See related Ensembl:ENSG00000165322 MIM:610577; AllianceGenome:HGNC:16348 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in stomach (RPKM 14.4), brain (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
ARHGAP15, Official Symbol ARHGAP15provided by HGNC Official Full Name Rho GTPase activating protein 15provided by HGNC Primary source HGNC:HGNC:21030 See related Ensembl:ENSG00000075884 MIM:610578; AllianceGenome:HGNC:21030 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BM046 Summary RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008] Expression Broad expression in lymph node (RPKM 10.3), bone marrow (RPKM 9.8) and 18 other tissues See more Orthologs mouse all
ARHGAP17, Official Symbol ARHGAP17provided by HGNC Official Full Name Rho GTPase activating protein 17provided by HGNC Primary source HGNC:HGNC:18239 See related Ensembl:ENSG00000140750 MIM:608293; AllianceGenome:HGNC:18239 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH-1; MSTP038; MSTP066; MSTP110 Summary RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in spleen (RPKM 24.3), lymph node (RPKM 19.6) and 25 other tissues See more Orthologs mouse all
ARHGAP18, Official Symbol ARHGAP18provided by HGNC Official Full Name Rho GTPase activating protein 18provided by HGNC Primary source HGNC:HGNC:21035 See related Ensembl:ENSG00000146376 MIM:613351; AllianceGenome:HGNC:21035 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SENEX; MacGAP; bA307O14.2 Summary Enables GTPase activator activity. Involved in several processes, including regulation of actin filament polymerization; regulation of small GTPase mediated signal transduction; and small GTPase mediated signal transduction. Located in cytosol; nuclear speck; and plasma membrane. Part of cytoplasmic microtubule and ruffle. Implicated in schizophrenia. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 22.0), lung (RPKM 16.4) and 25 other tissues See more Orthologs mouse all
ARHGAP19, Official Symbol ARHGAP19provided by HGNC Official Full Name Rho GTPase activating protein 19provided by HGNC Primary source HGNC:HGNC:23724 See related Ensembl:ENSG00000213390 MIM:611587; AllianceGenome:HGNC:23724 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008] Expression Broad expression in testis (RPKM 13.6), bone marrow (RPKM 8.1) and 24 other tissues See more Orthologs mouse all
ARHGAP19-SLIT1, Official Symbol ARHGAP19-SLIT1provided by HGNC Official Full Name ARHGAP19-SLIT1 readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:48348 See related Ensembl:ENSG00000269891 AllianceGenome:HGNC:48348 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARHGAP19 Summary This locus represents naturally occurring read-through transcription between the neighboring Rho GTPase activating protein 19 (ARHGAP19) and slit homolog 1 (SLIT1) genes on chromosome 10. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011] Expression Broad expression in testis (RPKM 11.0), lymph node (RPKM 5.6) and 23 other tissues See more
ARHGAP20, Official Symbol ARHGAP20provided by HGNC Official Full Name Rho GTPase activating protein 20provided by HGNC Primary source HGNC:HGNC:18357 See related Ensembl:ENSG00000137727 MIM:609568; AllianceGenome:HGNC:18357 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RARHOGAP Summary The protein encoded by this gene is an activator of RHO-type GTPases, transducing a signal from RAP1 to RHO and impacting neurite outgrowth. [provided by RefSeq, Sep 2016] Expression Broad expression in fat (RPKM 5.7), testis (RPKM 5.0) and 20 other tissues See more Orthologs mouse all
ARHGAP21, Official Symbol ARHGAP21provided by HGNC Official Full Name Rho GTPase activating protein 21provided by HGNC Primary source HGNC:HGNC:23725 See related Ensembl:ENSG00000107863 MIM:609870; AllianceGenome:HGNC:23725 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARHGAP10 Summary ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
ARHGAP22, Official Symbol ARHGAP22provided by HGNC Official Full Name Rho GTPase activating protein 22provided by HGNC Primary source HGNC:HGNC:30320 See related Ensembl:ENSG00000128805 MIM:610585; AllianceGenome:HGNC:30320 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RhoGAP2; RhoGap22 Summary This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
ARHGAP23, Official Symbol ARHGAP23provided by HGNC Official Full Name Rho GTPase activating protein 23provided by HGNC Primary source HGNC:HGNC:29293 See related Ensembl:ENSG00000275832 MIM:610590; AllianceGenome:HGNC:29293 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008] Expression Broad expression in skin (RPKM 13.7), brain (RPKM 13.2) and 22 other tissues See more Orthologs mouse all
ARHGAP23P1, Official Symbol ARHGAP23P1provided by HGNC Official Full Name Rho GTPase activating protein 23 pseudogene 1provided by HGNC Primary source HGNC:HGNC:45039 See related Ensembl:ENSG00000260781 AllianceGenome:HGNC:45039 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ARHGAP24, Official Symbol ARHGAP24provided by HGNC Official Full Name Rho GTPase activating protein 24provided by HGNC Primary source HGNC:HGNC:25361 See related Ensembl:ENSG00000138639 MIM:610586; AllianceGenome:HGNC:25361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP Summary This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Broad expression in kidney (RPKM 13.8), thyroid (RPKM 4.3) and 20 other tissues See more Orthologs mouse all
ARHGAP25, Official Symbol ARHGAP25provided by HGNC Official Full Name Rho GTPase activating protein 25provided by HGNC Primary source HGNC:HGNC:28951 See related Ensembl:ENSG00000163219 MIM:610587; AllianceGenome:HGNC:28951 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAIA0053; HEL-S-308 Summary ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008] Expression Broad expression in lymph node (RPKM 20.1), spleen (RPKM 18.9) and 23 other tissues See more Orthologs mouse all
ARHGAP26, Official Symbol ARHGAP26provided by HGNC Official Full Name Rho GTPase activating protein 26provided by HGNC Primary source HGNC:HGNC:17073 See related Ensembl:ENSG00000145819 MIM:605370; AllianceGenome:HGNC:17073 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRAF; GRAF1; OPHN1L; OPHN1L1 Summary Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in brain (RPKM 7.0), gall bladder (RPKM 4.5) and 24 other tissues See more Orthologs mouse all
ARHGAP26-AS1, Official Symbol ARHGAP26-AS1provided by HGNC Official Full Name ARHGAP26 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40792 See related Ensembl:ENSG00000226272 AllianceGenome:HGNC:40792 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.3) See more
ARHGAP26-IT1, Official Symbol ARHGAP26-IT1provided by HGNC Official Full Name ARHGAP26 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41429 See related Ensembl:ENSG00000230789 AllianceGenome:HGNC:41429 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.2) See more
ARHGAP27, Official Symbol ARHGAP27provided by HGNC Official Full Name Rho GTPase activating protein 27provided by HGNC Primary source HGNC:HGNC:31813 See related Ensembl:ENSG00000159314 MIM:610591; AllianceGenome:HGNC:31813 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP905; SH3D20; SH3P20; CAMGAP1 Summary This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in esophagus (RPKM 12.5), spleen (RPKM 12.5) and 23 other tissues See more Orthologs mouse all
ARHGAP27P1-BPTFP1-KPNA2P3, Official Symbol ARHGAP27P1-BPTFP1-KPNA2P3provided by HGNC Official Full Name ARHGAP27P1-BPTFP1-KPNA2P3 readthrough, transcribed pseudogeneprovided by HGNC Primary source HGNC:HGNC:52873 See related Ensembl:ENSG00000215769 AllianceGenome:HGNC:52873 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This locus represents naturally-occurring readthrough transcription between multiple unprocessed pseudogene loci. Readthrough transcripts likely do not encode functional proteins. [provided by RefSeq, Dec 2016]
ARHGAP28, Official Symbol ARHGAP28provided by HGNC Official Full Name Rho GTPase activating protein 28provided by HGNC Primary source HGNC:HGNC:25509 See related Ensembl:ENSG00000088756 MIM:610592; AllianceGenome:HGNC:25509 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of GTP binding activity; regulation of actin filament organization; and regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 21.0), placenta (RPKM 7.7) and 10 other tissues See more Orthologs mouse all
ARHGAP29, Official Symbol ARHGAP29provided by HGNC Official Full Name Rho GTPase activating protein 29provided by HGNC Primary source HGNC:HGNC:30207 See related Ensembl:ENSG00000137962 MIM:610496; AllianceGenome:HGNC:30207 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARG1 Summary Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016] Expression Broad expression in lung (RPKM 15.0), thyroid (RPKM 13.9) and 23 other tissues See more Orthologs mouse all
ARHGAP29-AS1, Official Symbol ARHGAP29-AS1provided by HGNC Official Full Name ARHGAP29 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54311 See related Ensembl:ENSG00000226835 AllianceGenome:HGNC:54311 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ARHGAP30, Official Symbol ARHGAP30provided by HGNC Official Full Name Rho GTPase activating protein 30provided by HGNC Primary source HGNC:HGNC:27414 See related Ensembl:ENSG00000186517 MIM:614264; AllianceGenome:HGNC:27414 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase mediated signal transduction. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 43.4), spleen (RPKM 39.2) and 17 other tissues See more Orthologs mouse all
ARHGAP31, Official Symbol ARHGAP31provided by HGNC Official Full Name Rho GTPase activating protein 31provided by HGNC Primary source HGNC:HGNC:29216 See related Ensembl:ENSG00000031081 MIM:610911; AllianceGenome:HGNC:29216 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AOS; AOS1; CDGAP Summary This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 13.9), fat (RPKM 10.8) and 22 other tissues See more Orthologs mouse all
ARHGAP31-AS1, Official Symbol ARHGAP31-AS1provided by HGNC Official Full Name ARHGAP31 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41235 See related Ensembl:ENSG00000241155 AllianceGenome:HGNC:41235 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ARHGAP32, Official Symbol ARHGAP32provided by HGNC Official Full Name Rho GTPase activating protein 32provided by HGNC Primary source HGNC:HGNC:17399 See related Ensembl:ENSG00000134909 MIM:608541; AllianceGenome:HGNC:17399 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP Summary RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues See more Orthologs mouse all
ARHGAP33, Official Symbol ARHGAP33provided by HGNC Official Full Name Rho GTPase activating protein 33provided by HGNC Primary source HGNC:HGNC:23085 See related Ensembl:ENSG00000004777 MIM:614902; AllianceGenome:HGNC:23085 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SNX26; TCGAP; NOMA-GAP Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010] Expression Broad expression in testis (RPKM 7.3), brain (RPKM 5.7) and 23 other tissues See more Orthologs mouse all
ARHGAP35, Official Symbol ARHGAP35provided by HGNC Official Full Name Rho GTPase activating protein 35provided by HGNC Primary source HGNC:HGNC:4591 See related Ensembl:ENSG00000160007 MIM:605277; AllianceGenome:HGNC:4591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP Summary The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues See more Orthologs mouse all
ARHGAP36, Official Symbol ARHGAP36provided by HGNC Official Full Name Rho GTPase activating protein 36provided by HGNC Primary source HGNC:HGNC:26388 See related Ensembl:ENSG00000147256 MIM:300937; AllianceGenome:HGNC:26388 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity and signal transduction. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward adrenal (RPKM 54.0) See more Orthologs mouse all
ARHGAP39, Official Symbol ARHGAP39provided by HGNC Official Full Name Rho GTPase activating protein 39provided by HGNC Primary source HGNC:HGNC:29351 See related Ensembl:ENSG00000147799 MIM:615880; AllianceGenome:HGNC:29351 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CrGAP; Vilse Summary Predicted to enable GTPase activator activity. Involved in postsynapse organization. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 5.1), brain (RPKM 1.6) and 17 other tissues See more Orthologs mouse all
ARHGAP4, Official Symbol ARHGAP4provided by HGNC Official Full Name Rho GTPase activating protein 4provided by HGNC Primary source HGNC:HGNC:674 See related Ensembl:ENSG00000089820 MIM:300023; AllianceGenome:HGNC:674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1; RGC1; p115; SrGAP4; RhoGAP4 Summary This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Broad expression in spleen (RPKM 47.8), bone marrow (RPKM 45.7) and 16 other tissues See more Orthologs mouse all
ARHGAP40, Official Symbol ARHGAP40provided by HGNC Official Full Name Rho GTPase activating protein 40provided by HGNC Primary source HGNC:HGNC:16226 See related Ensembl:ENSG00000124143 AllianceGenome:HGNC:16226 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C20orf95; dJ1100H13.4 Summary Predicted to enable GTPase activator activity. Predicted to be involved in regulation of actin filament polymerization and regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 12.2), esophagus (RPKM 3.7) and 4 other tissues See more Orthologs mouse all
ARHGAP42, Official Symbol ARHGAP42provided by HGNC Official Full Name Rho GTPase activating protein 42provided by HGNC Primary source HGNC:HGNC:26545 See related Ensembl:ENSG00000165895 MIM:615936; AllianceGenome:HGNC:26545 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD031; GRAF3; TMEM133 Summary This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in placenta (RPKM 4.3), thyroid (RPKM 3.5) and 24 other tissues See more Orthologs mouse all
ARHGAP42-AS1, Official Symbol ARHGAP42-AS1provided by HGNC Official Full Name ARHGAP42 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54801 See related Ensembl:ENSG00000248027 AllianceGenome:HGNC:54801 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ARHGAP42P1, Official Symbol ARHGAP42P1provided by HGNC Official Full Name ARHGAP42 pseudogene 1provided by HGNC Primary source HGNC:HGNC:43940 See related AllianceGenome:HGNC:43940 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ARHGAP44, Official Symbol ARHGAP44provided by HGNC Official Full Name Rho GTPase activating protein 44provided by HGNC Primary source HGNC:HGNC:29096 See related Ensembl:ENSG00000006740 MIM:617716; AllianceGenome:HGNC:29096 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RICH2; NPC-A-10 Summary Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 18.3), colon (RPKM 17.1) and 20 other tissues See more Orthologs mouse all
ARHGAP44-AS1, Official Symbol ARHGAP44-AS1provided by HGNC Official Full Name ARHGAP44 and MYOCD antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55326 See related Ensembl:ENSG00000265489 AllianceGenome:HGNC:55326 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in esophagus (RPKM 1.8), endometrium (RPKM 1.3) and 17 other tissues See more
ARHGAP45, Official Symbol ARHGAP45provided by HGNC Official Full Name Rho GTPase activating protein 45provided by HGNC Primary source HGNC:HGNC:17102 See related Ensembl:ENSG00000180448 MIM:601155; AllianceGenome:HGNC:17102 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HA-1; HMHA1; HLA-HA1 Summary Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 23.6), bone marrow (RPKM 17.0) and 22 other tissues See more Orthologs mouse all
ARHGAP5, Official Symbol ARHGAP5provided by HGNC Official Full Name Rho GTPase activating protein 5provided by HGNC Primary source HGNC:HGNC:675 See related Ensembl:ENSG00000100852 MIM:602680; AllianceGenome:HGNC:675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GFI2; p190-B; RhoGAP5; p190BRhoGAP Summary Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 21.1), brain (RPKM 17.8) and 25 other tissues See more Orthologs mouse all
ARHGAP6, Official Symbol ARHGAP6provided by HGNC Official Full Name Rho GTPase activating protein 6provided by HGNC Primary source HGNC:HGNC:676 See related Ensembl:ENSG00000047648 MIM:300118; AllianceGenome:HGNC:676 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHOGAP6; RHOGAPX-1 Summary This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in prostate (RPKM 12.6), thyroid (RPKM 10.2) and 18 other tissues See more Orthologs mouse all
ARHGAP8, Official Symbol ARHGAP8provided by HGNC Official Full Name Rho GTPase activating protein 8provided by HGNC Primary source HGNC:HGNC:677 See related Ensembl:ENSG00000241484 MIM:609405; AllianceGenome:HGNC:677 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP610; BPGAP1 Summary This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010] Expression Broad expression in kidney (RPKM 6.0), thyroid (RPKM 5.9) and 18 other tissues See more Orthologs mouse all
ARHGAP9, Official Symbol ARHGAP9provided by HGNC Official Full Name Rho GTPase activating protein 9provided by HGNC Primary source HGNC:HGNC:14130 See related Ensembl:ENSG00000123329 MIM:610576; AllianceGenome:HGNC:14130 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 10C; RGL1 Summary This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 23.2), bone marrow (RPKM 22.4) and 14 other tissues See more Orthologs mouse all