psui3905/ncbi_genes_summary huggingface dataset:
EIF3C, Official Symbol EIF3Cprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Cprovided by HGNC Primary source HGNC:HGNC:3279 See related Ensembl:ENSG00000184110 MIM:603916; AllianceGenome:HGNC:3279 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3CL; EIF3S8; eIF3-p110 Summary Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues See more Orthologs all
EIF3CL, Official Symbol EIF3CLprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit C likeprovided by HGNC Primary source HGNC:HGNC:26347 See related Ensembl:ENSG00000205609 AllianceGenome:HGNC:26347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in ovary (RPKM 103.1), thyroid (RPKM 97.8) and 25 other tissues See more Orthologs all
EIF3D, Official Symbol EIF3Dprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Dprovided by HGNC Primary source HGNC:HGNC:3278 See related Ensembl:ENSG00000100353 MIM:603915; AllianceGenome:HGNC:3278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3S7; eIF3-p66; eIF3-zeta Summary Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 83.0), lymph node (RPKM 75.1) and 25 other tissues See more Orthologs mouse all
EIF3E, Official Symbol EIF3Eprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Eprovided by HGNC Primary source HGNC:HGNC:3277 See related Ensembl:ENSG00000104408 MIM:602210; AllianceGenome:HGNC:3277 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT6; EIF3S6; EIF3-P48; eIF3-p46 Summary Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 226.7), lymph node (RPKM 138.2) and 25 other tissues See more Orthologs mouse all
EIF3EP1, Official Symbol EIF3EP1provided by HGNC Official Full Name EIF3E pseudogene 1provided by HGNC Primary source HGNC:HGNC:6102 See related Ensembl:ENSG00000234882 AllianceGenome:HGNC:6102 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3EP; INT6P1; EIF3S6P1
EIF3EP2, Official Symbol EIF3EP2provided by HGNC Official Full Name EIF3E pseudogene 2provided by HGNC Primary source HGNC:HGNC:37919 See related Ensembl:ENSG00000224674 AllianceGenome:HGNC:37919 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF3F, Official Symbol EIF3Fprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Fprovided by HGNC Primary source HGNC:HGNC:3275 See related Ensembl:ENSG00000175390 MIM:603914; AllianceGenome:HGNC:3275 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT67; EIF3S5; eIF3-p47 Summary Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 140.6), lymph node (RPKM 83.6) and 25 other tissues See more Orthologs mouse all
EIF3FP3, Official Symbol EIF3FP3provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit F pseudogene 3provided by HGNC Primary source HGNC:HGNC:37625 See related Ensembl:ENSG00000233426 AllianceGenome:HGNC:37625 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF3G, Official Symbol EIF3Gprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Gprovided by HGNC Primary source HGNC:HGNC:3274 See related Ensembl:ENSG00000130811 MIM:603913; AllianceGenome:HGNC:3274 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta Summary This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues See more Orthologs mouse all
EIF3H, Official Symbol EIF3Hprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Hprovided by HGNC Primary source HGNC:HGNC:3273 See related Ensembl:ENSG00000147677 MIM:603912; AllianceGenome:HGNC:3273 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3S3; eIF3-p40; eIF3-gamma Summary Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues See more Orthologs mouse all
EIF3I, Official Symbol EIF3Iprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Iprovided by HGNC Primary source HGNC:HGNC:3272 See related Ensembl:ENSG00000084623 MIM:603911; AllianceGenome:HGNC:3272 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta Summary Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 51.3), ovary (RPKM 48.1) and 25 other tissues See more Orthologs mouse all
EIF3IP1, Official Symbol EIF3IP1provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit I pseudogene 1provided by HGNC Primary source HGNC:HGNC:13277 See related Ensembl:ENSG00000237064 AllianceGenome:HGNC:13277 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RG208K23
EIF3J, Official Symbol EIF3Jprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Jprovided by HGNC Primary source HGNC:HGNC:3270 See related Ensembl:ENSG00000104131 MIM:603910; AllianceGenome:HGNC:3270 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3S1; eIF3-p35; eIF3-alpha Summary This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in appendix (RPKM 31.0), brain (RPKM 29.6) and 25 other tissues See more Orthologs mouse all
EIF3J-DT, Official Symbol EIF3J-DTprovided by HGNC Official Full Name EIF3J divergent transcriptprovided by HGNC Primary source HGNC:HGNC:48616 See related Ensembl:ENSG00000179523 AllianceGenome:HGNC:48616 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3J-AS1 Expression Ubiquitous expression in thyroid (RPKM 6.7), ovary (RPKM 5.2) and 25 other tissues See more
EIF3JP1, Official Symbol EIF3JP1provided by HGNC Official Full Name EIF3J pseudogene 1provided by HGNC Primary source HGNC:HGNC:55005 See related AllianceGenome:HGNC:55005 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF3K, Official Symbol EIF3Kprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Kprovided by HGNC Primary source HGNC:HGNC:24656 See related Ensembl:ENSG00000178982 MIM:609596; AllianceGenome:HGNC:24656 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M9; ARG134; PLAC24; PTD001; EIF3S12; HSPC029; MSTP001; PLAC-24; PRO1474; EIF3-p28 Summary The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in heart (RPKM 136.4), duodenum (RPKM 100.7) and 25 other tissues See more Orthologs mouse all
EIF3KP1, Official Symbol EIF3KP1provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit K pseudogene 1provided by HGNC Primary source HGNC:HGNC:44016 See related Ensembl:ENSG00000175749 AllianceGenome:HGNC:44016 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF3KP2, Official Symbol EIF3KP2provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit K pseudogene 2provided by HGNC Primary source HGNC:HGNC:44017 See related Ensembl:ENSG00000233544 AllianceGenome:HGNC:44017 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF3KP3, Official Symbol EIF3KP3provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit K pseudogene 3provided by HGNC Primary source HGNC:HGNC:44018 See related Ensembl:ENSG00000250442 AllianceGenome:HGNC:44018 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF3L, Official Symbol EIF3Lprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Lprovided by HGNC Primary source HGNC:HGNC:18138 See related Ensembl:ENSG00000100129 MIM:619197; AllianceGenome:HGNC:18138 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP Summary Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 248.8), thyroid (RPKM 164.0) and 25 other tissues See more Orthologs mouse all
EIF3LP1, Official Symbol EIF3LP1provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit L pseudogene 1provided by HGNC Primary source HGNC:HGNC:20010 See related Ensembl:ENSG00000258501 AllianceGenome:HGNC:20010 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3EIPP1; EIF3S6IPP
EIF3LP2, Official Symbol EIF3LP2provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit L pseudogene 2provided by HGNC Primary source HGNC:HGNC:24657 See related Ensembl:ENSG00000233837 AllianceGenome:HGNC:24657 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3EIPP2; EIF3S6IPP2
EIF3LP3, Official Symbol EIF3LP3provided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit L pseudogene 3provided by HGNC Primary source HGNC:HGNC:44976 See related Ensembl:ENSG00000226086 AllianceGenome:HGNC:44976 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF3M, Official Symbol EIF3Mprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Mprovided by HGNC Primary source HGNC:HGNC:24460 See related Ensembl:ENSG00000149100 MIM:609641; AllianceGenome:HGNC:24460 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B5; GA17; PCID1; TANGO7; hfl-B5 Summary This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues See more Orthologs mouse all
EIF3MP1, Official Symbol EIF3MP1provided by HGNC Official Full Name EIF3M pseudogene 1provided by HGNC Primary source HGNC:HGNC:55006 See related AllianceGenome:HGNC:55006 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1, Official Symbol EIF4A1provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1provided by HGNC Primary source HGNC:HGNC:3282 See related Ensembl:ENSG00000161960 MIM:602641; AllianceGenome:HGNC:3282 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I Summary Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in appendix (RPKM 182.3), bone marrow (RPKM 177.5) and 25 other tissues See more Orthologs mouse all
EIF4A1P1, Official Symbol EIF4A1P1provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:3283 See related Ensembl:ENSG00000233300 AllianceGenome:HGNC:3283 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF4A1P
EIF4A1P10, Official Symbol EIF4A1P10provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 10provided by HGNC Primary source HGNC:HGNC:37930 See related Ensembl:ENSG00000229132 AllianceGenome:HGNC:37930 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1P12, Official Symbol EIF4A1P12provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 12provided by HGNC Primary source HGNC:HGNC:37933 See related Ensembl:ENSG00000257662 AllianceGenome:HGNC:37933 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1P13, Official Symbol EIF4A1P13provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 13provided by HGNC Primary source HGNC:HGNC:37934 See related AllianceGenome:HGNC:37934 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1P2, Official Symbol EIF4A1P2provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:23946 See related Ensembl:ENSG00000235001 AllianceGenome:HGNC:23946 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1P3, Official Symbol EIF4A1P3provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:37922 See related AllianceGenome:HGNC:37922 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1P4, Official Symbol EIF4A1P4provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:37923 See related Ensembl:ENSG00000257790 AllianceGenome:HGNC:37923 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1P6, Official Symbol EIF4A1P6provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 6provided by HGNC Primary source HGNC:HGNC:37925 See related Ensembl:ENSG00000236608 AllianceGenome:HGNC:37925 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A1P7, Official Symbol EIF4A1P7provided by HGNC Official Full Name eukaryotic translation initiation factor 4A1 pseudogene 7provided by HGNC Primary source HGNC:HGNC:37926 See related Ensembl:ENSG00000235472 AllianceGenome:HGNC:37926 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A2, Official Symbol EIF4A2provided by HGNC Official Full Name eukaryotic translation initiation factor 4A2provided by HGNC Primary source HGNC:HGNC:3284 See related Ensembl:ENSG00000156976 MIM:601102; AllianceGenome:HGNC:3284 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX2B; EIF4A; EIF4F; BM-010; NEDHSS; eIF4A-II; eIF-4A-II Summary Enables ATP hydrolysis activity. Involved in negative regulation of RNA-directed 5'-3' RNA polymerase activity. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 426.9), brain (RPKM 313.7) and 25 other tissues See more Orthologs mouse all
EIF4A2P1, Official Symbol EIF4A2P1provided by HGNC Official Full Name eukaryotic translation initiation factor 4A2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:37929 See related AllianceGenome:HGNC:37929 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A2P2, Official Symbol EIF4A2P2provided by HGNC Official Full Name eukaryotic translation initiation factor 4A2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:45099 See related AllianceGenome:HGNC:45099 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A2P3, Official Symbol EIF4A2P3provided by HGNC Official Full Name eukaryotic translation initiation factor 4A2 pseudogene 3provided by HGNC Primary source HGNC:HGNC:45100 See related Ensembl:ENSG00000254589 AllianceGenome:HGNC:45100 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A2P4, Official Symbol EIF4A2P4provided by HGNC Official Full Name eukaryotic translation initiation factor 4A2 pseudogene 4provided by HGNC Primary source HGNC:HGNC:45101 See related Ensembl:ENSG00000224781 AllianceGenome:HGNC:45101 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A2P5, Official Symbol EIF4A2P5provided by HGNC Official Full Name eukaryotic translation initiation factor 4A2 pseudogene 5provided by HGNC Primary source HGNC:HGNC:45102 See related Ensembl:ENSG00000255490 AllianceGenome:HGNC:45102 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4A3, Official Symbol EIF4A3provided by HGNC Official Full Name eukaryotic translation initiation factor 4A3provided by HGNC Primary source HGNC:HGNC:18683 See related Ensembl:ENSG00000141543 MIM:608546; AllianceGenome:HGNC:18683 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Fal1; RCPS; DDX48; MUK34; NUK34; NMP265; eIF4AIII; eIF4A-III; eIF-4A-III Summary This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 66.0), adrenal (RPKM 43.4) and 25 other tissues See more Orthologs mouse all
EIF4B, Official Symbol EIF4Bprovided by HGNC Official Full Name eukaryotic translation initiation factor 4Bprovided by HGNC Primary source HGNC:HGNC:3285 See related Ensembl:ENSG00000063046 MIM:603928; AllianceGenome:HGNC:3285 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF-4B; PRO1843 Summary Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues See more Orthologs mouse all
EIF4BP2, Official Symbol EIF4BP2provided by HGNC Official Full Name eukaryotic translation initiation factor 4B pseudogene 2provided by HGNC Primary source HGNC:HGNC:37935 See related Ensembl:ENSG00000228753 AllianceGenome:HGNC:37935 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4BP3, Official Symbol EIF4BP3provided by HGNC Official Full Name eukaryotic translation initiation factor 4B pseudogene 3provided by HGNC Primary source HGNC:HGNC:37936 See related Ensembl:ENSG00000224546 AllianceGenome:HGNC:37936 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4BP4, Official Symbol EIF4BP4provided by HGNC Official Full Name eukaryotic translation initiation factor 4B pseudogene 4provided by HGNC Primary source HGNC:HGNC:37937 See related Ensembl:ENSG00000229572 AllianceGenome:HGNC:37937 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4BP5, Official Symbol EIF4BP5provided by HGNC Official Full Name eukaryotic translation initiation factor 4B pseudogene 5provided by HGNC Primary source HGNC:HGNC:37938 See related Ensembl:ENSG00000261336 AllianceGenome:HGNC:37938 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4BP8, Official Symbol EIF4BP8provided by HGNC Official Full Name eukaryotic translation initiation factor 4B pseudogene 8provided by HGNC Primary source HGNC:HGNC:37941 See related Ensembl:ENSG00000243918 AllianceGenome:HGNC:37941 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4E, Official Symbol EIF4Eprovided by HGNC Official Full Name eukaryotic translation initiation factor 4Eprovided by HGNC Primary source HGNC:HGNC:3287 See related Ensembl:ENSG00000151247 MIM:133440; AllianceGenome:HGNC:3287 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1 Summary The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
EIF4E1B, Official Symbol EIF4E1Bprovided by HGNC Official Full Name eukaryotic translation initiation factor 4E family member 1Bprovided by HGNC Primary source HGNC:HGNC:33179 See related Ensembl:ENSG00000175766 AllianceGenome:HGNC:33179 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in regulation of translation and translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex and mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
EIF4E2, Official Symbol EIF4E2provided by HGNC Official Full Name eukaryotic translation initiation factor 4E family member 2provided by HGNC Primary source HGNC:HGNC:3293 See related Ensembl:ENSG00000135930 MIM:605895; AllianceGenome:HGNC:3293 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 4EHP; IF4e; 4E-LP; h4EHP; EIF4EL3 Summary Enables ubiquitin protein ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 16.4), colon (RPKM 13.5) and 25 other tissues See more Orthologs mouse all
EIF4E2P1, Official Symbol EIF4E2P1provided by HGNC Official Full Name eukaryotic translation initiation factor 4E family member 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:16237 See related Ensembl:ENSG00000213384 AllianceGenome:HGNC:16237 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF4EL4; dJ1049G11.3
EIF4E2P2, Official Symbol EIF4E2P2provided by HGNC Official Full Name eukaryotic translation initiation factor 4E family member 2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:51464 See related AllianceGenome:HGNC:51464 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4E3, Official Symbol EIF4E3provided by HGNC Official Full Name eukaryotic translation initiation factor 4E family member 3provided by HGNC Primary source HGNC:HGNC:31837 See related Ensembl:ENSG00000163412 MIM:609896; AllianceGenome:HGNC:31837 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as eIF-4E3; eIF4E-3 Summary EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in fat (RPKM 11.9), brain (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
EIF4EBP1, Official Symbol EIF4EBP1provided by HGNC Official Full Name eukaryotic translation initiation factor 4E binding protein 1provided by HGNC Primary source HGNC:HGNC:3288 See related Ensembl:ENSG00000187840 MIM:602223; AllianceGenome:HGNC:3288 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BP-1; 4EBP1; 4E-BP1; PHAS-I Summary This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in salivary gland (RPKM 30.3), fat (RPKM 26.3) and 25 other tissues See more Orthologs mouse all
EIF4EBP2, Official Symbol EIF4EBP2provided by HGNC Official Full Name eukaryotic translation initiation factor 4E binding protein 2provided by HGNC Primary source HGNC:HGNC:3289 See related Ensembl:ENSG00000148730 MIM:602224; AllianceGenome:HGNC:3289 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 4EBP2; PHASII Summary This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in fat (RPKM 50.2), kidney (RPKM 34.8) and 25 other tissues See more Orthologs mouse all
EIF4EBP2P3, Official Symbol EIF4EBP2P3provided by HGNC Official Full Name eukaryotic translation initiation factor 4E binding protein 2 pseudogene 3provided by HGNC Primary source HGNC:HGNC:49318 See related AllianceGenome:HGNC:49318 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4EBP3, Official Symbol EIF4EBP3provided by HGNC Official Full Name eukaryotic translation initiation factor 4E binding protein 3provided by HGNC Primary source HGNC:HGNC:3290 See related Ensembl:ENSG00000243056 MIM:603483; AllianceGenome:HGNC:3290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 4EBP3; 4E-BP3 Summary This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in adrenal (RPKM 14.1), kidney (RPKM 13.1) and 25 other tissues See more Orthologs mouse all
EIF4ENIF1, Official Symbol EIF4ENIF1provided by HGNC Official Full Name eukaryotic translation initiation factor 4E nuclear import factor 1provided by HGNC Primary source HGNC:HGNC:16687 See related Ensembl:ENSG00000184708 MIM:607445; AllianceGenome:HGNC:16687 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 4E-T; Clast4 Summary The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] Expression Broad expression in testis (RPKM 19.7), brain (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
EIF4EP4, Official Symbol EIF4EP4provided by HGNC Official Full Name eukaryotic translation initiation factor 4E pseudogene 4provided by HGNC Primary source HGNC:HGNC:51462 See related Ensembl:ENSG00000232968 AllianceGenome:HGNC:51462 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF4G1, Official Symbol EIF4G1provided by HGNC Official Full Name eukaryotic translation initiation factor 4 gamma 1provided by HGNC Primary source HGNC:HGNC:3296 See related Ensembl:ENSG00000114867 MIM:600495; AllianceGenome:HGNC:3296 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1 Summary The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues See more Orthologs mouse all
EIF4G2, Official Symbol EIF4G2provided by HGNC Official Full Name eukaryotic translation initiation factor 4 gamma 2provided by HGNC Primary source HGNC:HGNC:3297 See related Ensembl:ENSG00000110321 MIM:602325; AllianceGenome:HGNC:3297 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P97; AAG1; DAP5; NAT1 Summary Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 207.4), placenta (RPKM 201.0) and 25 other tissues See more Orthologs mouse all
EIF4G3, Official Symbol EIF4G3provided by HGNC Official Full Name eukaryotic translation initiation factor 4 gamma 3provided by HGNC Primary source HGNC:HGNC:3298 See related Ensembl:ENSG00000075151 MIM:603929; AllianceGenome:HGNC:3298 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as eIF4G 3; eIF4GII; eIF-4G 3 Summary The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016] Expression Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues See more Orthologs mouse all
EIF4H, Official Symbol EIF4Hprovided by HGNC Official Full Name eukaryotic translation initiation factor 4Hprovided by HGNC Primary source HGNC:HGNC:12741 See related Ensembl:ENSG00000106682 MIM:603431; AllianceGenome:HGNC:12741 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WSCR1; WBSCR1; eIF-4H Summary This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 113.5), placenta (RPKM 104.0) and 25 other tissues See more Orthologs mouse all
EIF5, Official Symbol EIF5provided by HGNC Official Full Name eukaryotic translation initiation factor 5provided by HGNC Primary source HGNC:HGNC:3299 See related Ensembl:ENSG00000100664 MIM:601710; AllianceGenome:HGNC:3299 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF-5; EIF-5A Summary Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010] Expression Ubiquitous expression in bone marrow (RPKM 60.5), thyroid (RPKM 44.5) and 25 other tissues See more Orthologs mouse all