psui3905/ncbi_genes_summary huggingface dataset:
MAP2K3, Official Symbol MAP2K3provided by HGNC Official Full Name mitogen-activated protein kinase kinase 3provided by HGNC Primary source HGNC:HGNC:6843 See related Ensembl:ENSG00000034152 MIM:602315; AllianceGenome:HGNC:6843 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2 Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 62.9), gall bladder (RPKM 18.4) and 23 other tissues See more Orthologs mouse all
MAP2K4, Official Symbol MAP2K4provided by HGNC Official Full Name mitogen-activated protein kinase kinase 4provided by HGNC Primary source HGNC:HGNC:6844 See related Ensembl:ENSG00000065559 MIM:601335; AllianceGenome:HGNC:6844 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1 Summary This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in brain (RPKM 23.5), thyroid (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
MAP2K4P1, Official Symbol MAP2K4P1provided by HGNC Official Full Name mitogen-activated protein kinase kinase 4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:43837 See related Ensembl:ENSG00000269904 AllianceGenome:HGNC:43837 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 1.1), thyroid (RPKM 0.4) and 24 other tissues See more
MAP2K5, Official Symbol MAP2K5provided by HGNC Official Full Name mitogen-activated protein kinase kinase 5provided by HGNC Primary source HGNC:HGNC:6845 See related Ensembl:ENSG00000137764 MIM:602520; AllianceGenome:HGNC:6845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEK5; MAPKK5; PRKMK5; HsT17454 Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] Expression Ubiquitous expression in ovary (RPKM 2.0), testis (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
MAP2K6, Official Symbol MAP2K6provided by HGNC Official Full Name mitogen-activated protein kinase kinase 6provided by HGNC Primary source HGNC:HGNC:6846 See related Ensembl:ENSG00000108984 MIM:601254; AllianceGenome:HGNC:6846 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3 Summary This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues See more Orthologs mouse all
MAP2K7, Official Symbol MAP2K7provided by HGNC Official Full Name mitogen-activated protein kinase kinase 7provided by HGNC Primary source HGNC:HGNC:6847 See related Ensembl:ENSG00000076984 MIM:603014; AllianceGenome:HGNC:6847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4 Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
MAP3K1, Official Symbol MAP3K1provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 1provided by HGNC Primary source HGNC:HGNC:6848 See related Ensembl:ENSG00000095015 MIM:600982; AllianceGenome:HGNC:6848 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1 Summary The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in spleen (RPKM 8.6), skin (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
MAP3K10, Official Symbol MAP3K10provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 10provided by HGNC Primary source HGNC:HGNC:6849 See related Ensembl:ENSG00000130758 MIM:600137; AllianceGenome:HGNC:6849 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST; MLK2; MEKK10 Summary The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues See more Orthologs mouse all
MAP3K11, Official Symbol MAP3K11provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 11provided by HGNC Primary source HGNC:HGNC:6850 See related Ensembl:ENSG00000173327 MIM:600050; AllianceGenome:HGNC:6850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLK3; PTK1; SPRK; MLK-3; MEKK11 Summary The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 25.3), fat (RPKM 22.6) and 25 other tissues See more Orthologs mouse all
MAP3K12, Official Symbol MAP3K12provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 12provided by HGNC Primary source HGNC:HGNC:6851 See related Ensembl:ENSG00000139625 MIM:600447; AllianceGenome:HGNC:6851 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DLK; MUK; ZPK; ZPKP1; MEKK12; HP09298 Summary This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] Expression Ubiquitous expression in urinary bladder (RPKM 14.0), brain (RPKM 12.1) and 25 other tissues See more Orthologs mouse all
MAP3K13, Official Symbol MAP3K13provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 13provided by HGNC Primary source HGNC:HGNC:6852 See related Ensembl:ENSG00000073803 MIM:604915; AllianceGenome:HGNC:6852 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LZK; MLK; MEKK13 Summary The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
MAP3K14, Official Symbol MAP3K14provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 14provided by HGNC Primary source HGNC:HGNC:6853 See related Ensembl:ENSG00000006062 MIM:604655; AllianceGenome:HGNC:6853 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HS; NIK; HSNIK; IMD112; FTDCR1B Summary This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 11.1), spleen (RPKM 8.5) and 25 other tissues See more Orthologs mouse all
MAP3K15, Official Symbol MAP3K15provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 15provided by HGNC Primary source HGNC:HGNC:31689 See related Ensembl:ENSG00000180815 MIM:300820; AllianceGenome:HGNC:31689 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASK3; bA723P2.3 Summary The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in adrenal (RPKM 7.5), heart (RPKM 3.2) and 24 other tissues See more Orthologs mouse all
MAP3K19, Official Symbol MAP3K19provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 19provided by HGNC Primary source HGNC:HGNC:26249 See related Ensembl:ENSG00000176601 AllianceGenome:HGNC:26249 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCK; YSK4 Summary Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 2.7), lung (RPKM 0.8) and 1 other tissue See more Orthologs mouse all
MAP3K2, Official Symbol MAP3K2provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 2provided by HGNC Primary source HGNC:HGNC:6854 See related Ensembl:ENSG00000169967 MIM:609487; AllianceGenome:HGNC:6854 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEKK2; MEKK2B Summary The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 11.2), thyroid (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
MAP3K2-DT, Official Symbol MAP3K2-DTprovided by HGNC Official Full Name MAP3K2 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:54088 See related AllianceGenome:HGNC:54088 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MAP3K20, Official Symbol MAP3K20provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 20provided by HGNC Primary source HGNC:HGNC:17797 See related Ensembl:ENSG00000091436 MIM:609479; AllianceGenome:HGNC:17797 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha Summary This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in heart (RPKM 51.0), fat (RPKM 33.9) and 21 other tissues See more Orthologs mouse all
MAP3K20-AS1, Official Symbol MAP3K20-AS1provided by HGNC Official Full Name MAP3K20 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:27935 See related Ensembl:ENSG00000238133 AllianceGenome:HGNC:27935 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLK7-AS1 Expression Broad expression in heart (RPKM 6.8), endometrium (RPKM 4.1) and 22 other tissues See more
MAP3K21, Official Symbol MAP3K21provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 21provided by HGNC Primary source HGNC:HGNC:29798 See related Ensembl:ENSG00000143674 MIM:614793; AllianceGenome:HGNC:29798 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLK4; dJ862P8.3 Summary Predicted to enable protein homodimerization activity and protein kinase activity. Predicted to be involved in protein autophosphorylation and signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 6.4), kidney (RPKM 5.7) and 21 other tissues See more Orthologs mouse all
MAP3K3, Official Symbol MAP3K3provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 3provided by HGNC Primary source HGNC:HGNC:6855 See related Ensembl:ENSG00000198909 MIM:602539; AllianceGenome:HGNC:6855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEKK3; MAPKKK3 Summary This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 15.4), lung (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
MAP3K4, Official Symbol MAP3K4provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 4provided by HGNC Primary source HGNC:HGNC:6856 See related Ensembl:ENSG00000085511 MIM:602425; AllianceGenome:HGNC:6856 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTK1; MEKK4; MEKK 4; MAPKKK4; PRO0412 Summary The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014] Expression Ubiquitous expression in testis (RPKM 9.3), endometrium (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
MAP3K4-AS1, Official Symbol MAP3K4-AS1provided by HGNC Official Full Name MAP3K4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55048 See related Ensembl:ENSG00000272841 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MAP3K5, Official Symbol MAP3K5provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 5provided by HGNC Primary source HGNC:HGNC:6857 See related Ensembl:ENSG00000197442 MIM:602448; AllianceGenome:HGNC:6857 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASK1; MEKK5; MAPKKK5 Summary Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] Expression Broad expression in adrenal (RPKM 43.3), ovary (RPKM 21.3) and 23 other tissues See more Orthologs mouse all
MAP3K5-AS1, Official Symbol MAP3K5-AS1provided by HGNC Official Full Name MAP3K5 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40358 See related Ensembl:ENSG00000234263 AllianceGenome:HGNC:40358 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 8.7) See more
MAP3K6, Official Symbol MAP3K6provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 6provided by HGNC Primary source HGNC:HGNC:6858 See related Ensembl:ENSG00000142733 MIM:604468; AllianceGenome:HGNC:6858 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASK2; MEKK6; MAPKKK6 Summary This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Broad expression in skin (RPKM 18.7), fat (RPKM 11.6) and 21 other tissues See more Orthologs mouse all
MAP3K7, Official Symbol MAP3K7provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 7provided by HGNC Primary source HGNC:HGNC:6859 See related Ensembl:ENSG00000135341 MIM:602614; AllianceGenome:HGNC:6859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSCF; FMD2; TAK1; MEKK7; TGF1a Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 10.0), endometrium (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
MAP3K7CL, Official Symbol MAP3K7CLprovided by HGNC Official Full Name MAP3K7 C-terminal likeprovided by HGNC Primary source HGNC:HGNC:16457 See related Ensembl:ENSG00000156265 MIM:611110; AllianceGenome:HGNC:16457 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAKL; TAK1L; TAKL-1; TAKL-2; TAKL-4; C21orf7; HC21ORF7 Summary Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 4.1), prostate (RPKM 2.4) and 24 other tissues See more Orthologs mouse all
MAP3K8, Official Symbol MAP3K8provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 8provided by HGNC Primary source HGNC:HGNC:6860 See related Ensembl:ENSG00000107968 MIM:191195; AllianceGenome:HGNC:6860 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT Summary This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Expression Broad expression in bone marrow (RPKM 18.4), appendix (RPKM 6.8) and 17 other tissues See more Orthologs mouse all
MAP3K9, Official Symbol MAP3K9provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase 9provided by HGNC Primary source HGNC:HGNC:6861 See related Ensembl:ENSG00000006432 MIM:600136; AllianceGenome:HGNC:6861 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLK1; MEKK9; PRKE1 Summary Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 3.6), testis (RPKM 3.0) and 22 other tissues See more Orthologs mouse all
MAP4, Official Symbol MAP4provided by HGNC Official Full Name microtubule associated protein 4provided by HGNC Primary source HGNC:HGNC:6862 See related Ensembl:ENSG00000047849 MIM:157132; AllianceGenome:HGNC:6862 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in heart (RPKM 53.7), brain (RPKM 28.3) and 23 other tissues See more Orthologs mouse all
MAP4K1, Official Symbol MAP4K1provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase kinase 1provided by HGNC Primary source HGNC:HGNC:6863 See related Ensembl:ENSG00000104814 MIM:601983; AllianceGenome:HGNC:6863 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPK1 Summary Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 28.4), spleen (RPKM 19.4) and 10 other tissues See more Orthologs mouse all
MAP4K1-AS1, Official Symbol MAP4K1-AS1provided by HGNC Official Full Name MAP4K1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55302 See related Ensembl:ENSG00000267291 AllianceGenome:HGNC:55302 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in lymph node (RPKM 13.7), spleen (RPKM 10.4) and 12 other tissues See more
MAP4K2, Official Symbol MAP4K2provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase kinase 2provided by HGNC Primary source HGNC:HGNC:6864 See related Ensembl:ENSG00000168067 MIM:603166; AllianceGenome:HGNC:6864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCK; BL44; RAB8IP Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Expression Broad expression in spleen (RPKM 10.3), lymph node (RPKM 8.4) and 24 other tissues See more Orthologs mouse all
MAP4K3, Official Symbol MAP4K3provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase kinase 3provided by HGNC Primary source HGNC:HGNC:6865 See related Ensembl:ENSG00000011566 MIM:604921; AllianceGenome:HGNC:6865 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1 Summary This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 14.7), testis (RPKM 13.3) and 25 other tissues See more Orthologs mouse all
MAP4K3-DT, Official Symbol MAP4K3-DTprovided by HGNC Official Full Name MAP4K3 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:54056 See related Ensembl:ENSG00000231312 AllianceGenome:HGNC:54056 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 2.0), kidney (RPKM 1.5) and 24 other tissues See more
MAP4K4, Official Symbol MAP4K4provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC Primary source HGNC:HGNC:6866 See related Ensembl:ENSG00000071054 MIM:604666; AllianceGenome:HGNC:6866 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HGK; NIK; MEKKK4; FLH21957; HEL-S-31 Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues See more Orthologs mouse all
MAP4K5, Official Symbol MAP4K5provided by HGNC Official Full Name mitogen-activated protein kinase kinase kinase kinase 5provided by HGNC Primary source HGNC:HGNC:6867 See related Ensembl:ENSG00000012983 MIM:604923; AllianceGenome:HGNC:6867 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KHS; GCKR; KHS1; MAPKKKK5 Summary This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 13.1), ovary (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
MAP6, Official Symbol MAP6provided by HGNC Official Full Name microtubule associated protein 6provided by HGNC Primary source HGNC:HGNC:6868 See related Ensembl:ENSG00000171533 MIM:601783; AllianceGenome:HGNC:6868 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STOP; MTAP6; MAP6-N; N-STOP Summary This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.6), testis (RPKM 2.8) and 13 other tissues See more Orthologs mouse all
MAP6D1, Official Symbol MAP6D1provided by HGNC Official Full Name MAP6 domain containing 1provided by HGNC Primary source HGNC:HGNC:25753 See related Ensembl:ENSG00000180834 MIM:610593; AllianceGenome:HGNC:25753 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SL21; MAPO6D1 Summary This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008] Expression Biased expression in brain (RPKM 16.9), skin (RPKM 1.5) and 2 other tissues See more Orthologs mouse all
MAP7, Official Symbol MAP7provided by HGNC Official Full Name microtubule associated protein 7provided by HGNC Primary source HGNC:HGNC:6869 See related Ensembl:ENSG00000135525 MIM:604108; AllianceGenome:HGNC:6869 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EMAP115; E-MAP-115 Summary The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] Expression Broad expression in kidney (RPKM 10.5), brain (RPKM 10.5) and 21 other tissues See more Orthologs mouse all
MAP7D1, Official Symbol MAP7D1provided by HGNC Official Full Name MAP7 domain containing 1provided by HGNC Primary source HGNC:HGNC:25514 See related Ensembl:ENSG00000116871 AllianceGenome:HGNC:25514 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPRC1; PARCC1 Summary Predicted to be involved in microtubule cytoskeleton organization. Located in cytosol and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 43.2), brain (RPKM 39.0) and 24 other tissues See more Orthologs mouse all
MAP7D2, Official Symbol MAP7D2provided by HGNC Official Full Name MAP7 domain containing 2provided by HGNC Primary source HGNC:HGNC:25899 See related Ensembl:ENSG00000184368 AllianceGenome:HGNC:25899 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 8.5), testis (RPKM 4.5) and 4 other tissues See more Orthologs mouse all
MAP7D3, Official Symbol MAP7D3provided by HGNC Official Full Name MAP7 domain containing 3provided by HGNC Primary source HGNC:HGNC:25742 See related Ensembl:ENSG00000129680 MIM:300930; AllianceGenome:HGNC:25742 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MDP3 Summary The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010] Expression Broad expression in testis (RPKM 6.8), fat (RPKM 4.8) and 24 other tissues See more Orthologs mouse all
MAP9, Official Symbol MAP9provided by HGNC Official Full Name microtubule associated protein 9provided by HGNC Primary source HGNC:HGNC:26118 See related Ensembl:ENSG00000164114 MIM:610070; AllianceGenome:HGNC:26118 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASAP Summary ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008] Expression Broad expression in brain (RPKM 7.7), thyroid (RPKM 7.3) and 23 other tissues See more Orthologs mouse all
MAPK1, Official Symbol MAPK1provided by HGNC Official Full Name mitogen-activated protein kinase 1provided by HGNC Primary source HGNC:HGNC:6871 See related Ensembl:ENSG00000100030 MIM:176948; AllianceGenome:HGNC:6871 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERK; p38; p40; p41; ERK2; ERT1; NS13; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK Summary This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in brain (RPKM 63.3), thyroid (RPKM 32.9) and 25 other tissues See more Orthologs mouse all
MAPK10, Official Symbol MAPK10provided by HGNC Official Full Name mitogen-activated protein kinase 10provided by HGNC Primary source HGNC:HGNC:6872 See related Ensembl:ENSG00000109339 MIM:602897; AllianceGenome:HGNC:6872 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] Expression Biased expression in brain (RPKM 15.3), fat (RPKM 4.4) and 11 other tissues See more Orthologs mouse all