psui3905/ncbi_genes_summary huggingface dataset:
GRB7, Official Symbol GRB7provided by HGNC Official Full Name growth factor receptor bound protein 7provided by HGNC Primary source HGNC:HGNC:4567 See related Ensembl:ENSG00000141738 MIM:601522; AllianceGenome:HGNC:4567 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] Expression Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues See more Orthologs mouse all
GREB1, Official Symbol GREB1provided by HGNC Official Full Name growth regulating estrogen receptor binding 1provided by HGNC Primary source HGNC:HGNC:24885 See related Ensembl:ENSG00000196208 MIM:611736; AllianceGenome:HGNC:24885 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in ovary (RPKM 38.8), prostate (RPKM 13.2) and 2 other tissues See more Orthologs mouse all
GREB1L, Official Symbol GREB1Lprovided by HGNC Official Full Name GREB1 like retinoic acid receptor coactivatorprovided by HGNC Primary source HGNC:HGNC:31042 See related Ensembl:ENSG00000141449 MIM:617782; AllianceGenome:HGNC:31042 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHDA3; DFNA80; C18orf6; KIAA1772 Summary Acts upstream of or within kidney development. Predicted to be integral component of membrane. Implicated in autosomal dominant nonsyndromic deafness and renal agenesis. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 2.5), thyroid (RPKM 1.4) and 11 other tissues See more Orthologs mouse all
GREB1L-DT, Official Symbol GREB1L-DTprovided by HGNC Official Full Name GREB1L divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55323 See related AllianceGenome:HGNC:55323 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
GREM1, Official Symbol GREM1provided by HGNC Official Full Name gremlin 1, DAN family BMP antagonistprovided by HGNC Primary source HGNC:HGNC:2001 See related Ensembl:ENSG00000166923 MIM:603054; AllianceGenome:HGNC:2001 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1 Summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] Expression Biased expression in gall bladder (RPKM 205.9), appendix (RPKM 84.5) and 6 other tissues See more Orthologs mouse all
GREM2, Official Symbol GREM2provided by HGNC Official Full Name gremlin 2, DAN family BMP antagonistprovided by HGNC Primary source HGNC:HGNC:17655 See related Ensembl:ENSG00000180875 MIM:608832; AllianceGenome:HGNC:17655 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRDC; DAND3; STHAG9; CKTSF1B2 Summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 20.4), colon (RPKM 11.9) and 14 other tissues See more Orthologs mouse all
GRHL1, Official Symbol GRHL1provided by HGNC Official Full Name grainyhead like transcription factor 1provided by HGNC Primary source HGNC:HGNC:17923 See related Ensembl:ENSG00000134317 MIM:609786; AllianceGenome:HGNC:17923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGR; NH32; LBP32; TFCP2L2 Summary This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009] Expression Biased expression in esophagus (RPKM 42.3), skin (RPKM 29.2) and 4 other tissues See more Orthologs mouse all
GRHL2, Official Symbol GRHL2provided by HGNC Official Full Name grainyhead like transcription factor 2provided by HGNC Primary source HGNC:HGNC:2799 See related Ensembl:ENSG00000083307 MIM:608576; AllianceGenome:HGNC:2799 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BOM; ECTDS; PPCD4; DFNA28; TFCP2L3 Summary The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009] Expression Broad expression in skin (RPKM 14.0), prostate (RPKM 13.5) and 14 other tissues See more Orthologs mouse all
GRHL3, Official Symbol GRHL3provided by HGNC Official Full Name grainyhead like transcription factor 3provided by HGNC Primary source HGNC:HGNC:25839 See related Ensembl:ENSG00000158055 MIM:608317; AllianceGenome:HGNC:25839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SOM; VWS2; TFCP2L4 Summary This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Aug 2010] Expression Biased expression in esophagus (RPKM 31.7), skin (RPKM 14.0) and 1 other tissue See more Orthologs mouse all
GRHPR, Official Symbol GRHPRprovided by HGNC Official Full Name glyoxylate and hydroxypyruvate reductaseprovided by HGNC Primary source HGNC:HGNC:4570 See related Ensembl:ENSG00000137106 MIM:604296; AllianceGenome:HGNC:4570 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PH2; GLXR; GLYD Summary This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 132.9), kidney (RPKM 67.4) and 24 other tissues See more Orthologs mouse all
GRIA1, Official Symbol GRIA1provided by HGNC Official Full Name glutamate ionotropic receptor AMPA type subunit 1provided by HGNC Primary source HGNC:HGNC:4571 See related Ensembl:ENSG00000155511 MIM:138248; AllianceGenome:HGNC:4571 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLUH1; GLUR1; GLURA; GluA1; HBGR1; MRD67; MRT76 Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 23.3) and lung (RPKM 3.7) See more Orthologs mouse all
GRIA2, Official Symbol GRIA2provided by HGNC Official Full Name glutamate ionotropic receptor AMPA type subunit 2provided by HGNC Primary source HGNC:HGNC:4572 See related Ensembl:ENSG00000120251 MIM:138247; AllianceGenome:HGNC:4572 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2 Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward brain (RPKM 36.3) See more Orthologs mouse all
GRIA3, Official Symbol GRIA3provided by HGNC Official Full Name glutamate ionotropic receptor AMPA type subunit 3provided by HGNC Primary source HGNC:HGNC:4573 See related Ensembl:ENSG00000125675 MIM:305915; AllianceGenome:HGNC:4573 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLUR3; GLURC; GluA3; MRX94; MRXSW; GLUR-C; iGluR3; GLUR-K3 Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 19.9), adrenal (RPKM 3.0) and 1 other tissue See more Orthologs mouse all
GRIA4, Official Symbol GRIA4provided by HGNC Official Full Name glutamate ionotropic receptor AMPA type subunit 4provided by HGNC Primary source HGNC:HGNC:4574 See related Ensembl:ENSG00000152578 MIM:138246; AllianceGenome:HGNC:4574 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLUR4; GLURD; GluA4; GLUR4C; NEDSGA; GluA4-ATD Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 8.8), adrenal (RPKM 0.9) and 1 other tissue See more Orthologs mouse all
GRID1, Official Symbol GRID1provided by HGNC Official Full Name glutamate ionotropic receptor delta type subunit 1provided by HGNC Primary source HGNC:HGNC:4575 See related Ensembl:ENSG00000182771 MIM:610659; AllianceGenome:HGNC:4575 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GluD1; GluD1-b Summary This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009] Expression Biased expression in brain (RPKM 6.7), thyroid (RPKM 3.7) and 12 other tissues See more Orthologs mouse all
GRID1-AS1, Official Symbol GRID1-AS1provided by HGNC Official Full Name GRID1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44131 See related Ensembl:ENSG00000234942 AllianceGenome:HGNC:44131 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.4) See more
GRID2, Official Symbol GRID2provided by HGNC Official Full Name glutamate ionotropic receptor delta type subunit 2provided by HGNC Primary source HGNC:HGNC:4576 See related Ensembl:ENSG00000152208 MIM:602368; AllianceGenome:HGNC:4576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GluD2; SCAR18 Summary The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all
GRID2IP, Official Symbol GRID2IPprovided by HGNC Official Full Name Grid2 interacting proteinprovided by HGNC Primary source HGNC:HGNC:18464 See related Ensembl:ENSG00000215045 MIM:610639; AllianceGenome:HGNC:18464 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DELPHILIN Summary Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
GRIFIN, Official Symbol GRIFINprovided by HGNC Official Full Name galectin-related inter-fiber proteinprovided by HGNC Primary source HGNC:HGNC:4577 See related Ensembl:ENSG00000275572 MIM:619187; AllianceGenome:HGNC:4577 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable carbohydrate binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
GRIK1, Official Symbol GRIK1provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 1provided by HGNC Primary source HGNC:HGNC:4579 See related Ensembl:ENSG00000171189 MIM:138245; AllianceGenome:HGNC:4579 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5 Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 3.8), brain (RPKM 1.9) and 2 other tissues See more Orthologs mouse all
GRIK2, Official Symbol GRIK2provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 2provided by HGNC Primary source HGNC:HGNC:4580 See related Ensembl:ENSG00000164418 MIM:138244; AllianceGenome:HGNC:4580 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2; NEDLAS Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 2.7), heart (RPKM 0.6) and 5 other tissues See more Orthologs mouse all
GRIK3, Official Symbol GRIK3provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 3provided by HGNC Primary source HGNC:HGNC:4581 See related Ensembl:ENSG00000163873 MIM:138243; AllianceGenome:HGNC:4581 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAA5; GLR7; GLUR7; GluK3; GluR7a Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues See more Orthologs mouse all
GRIK4, Official Symbol GRIK4provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 4provided by HGNC Primary source HGNC:HGNC:4582 See related Ensembl:ENSG00000149403 MIM:600282; AllianceGenome:HGNC:4582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KA1; EAA1; GRIK; GluK4; GluK4-2 Summary This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Expression Biased expression in brain (RPKM 2.8), ovary (RPKM 0.9) and 4 other tissues See more Orthologs mouse all
GRIK5, Official Symbol GRIK5provided by HGNC Official Full Name glutamate ionotropic receptor kainate type subunit 5provided by HGNC Primary source HGNC:HGNC:4583 See related Ensembl:ENSG00000105737 MIM:600283; AllianceGenome:HGNC:4583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KA2; EAA2; GRIK2; GluK5 Summary This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Broad expression in testis (RPKM 5.6), brain (RPKM 5.5) and 14 other tissues See more Orthologs mouse all
GRIN1, Official Symbol GRIN1provided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit 1provided by HGNC Primary source HGNC:HGNC:4584 See related Ensembl:ENSG00000176884 MIM:138249; AllianceGenome:HGNC:4584 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR1; MRD8; GluN1; NMDA1; DEE101; NDHMSD; NDHMSR; NMD-R1; NMDAR1 Summary The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] Expression Restricted expression toward brain (RPKM 50.5) See more Orthologs mouse all
GRIN2A, Official Symbol GRIN2Aprovided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit 2Aprovided by HGNC Primary source HGNC:HGNC:4585 See related Ensembl:ENSG00000183454 MIM:138253; AllianceGenome:HGNC:4585 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A Summary This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Biased expression in brain (RPKM 9.5), heart (RPKM 0.9) and 2 other tissues See more Orthologs mouse all
GRIN2B, Official Symbol GRIN2Bprovided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit 2Bprovided by HGNC Primary source HGNC:HGNC:4586 See related Ensembl:ENSG00000273079 MIM:138252; AllianceGenome:HGNC:4586 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR3; MRD6; NR2B; hNR3; DEE27; EIEE27; GluN2B; NMDAR2B Summary This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017] Expression Biased expression in brain (RPKM 5.9) and testis (RPKM 0.2) See more Orthologs mouse all
GRIN2C, Official Symbol GRIN2Cprovided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit 2Cprovided by HGNC Primary source HGNC:HGNC:4587 See related Ensembl:ENSG00000161509 MIM:138254; AllianceGenome:HGNC:4587 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR2C; GluN2C; NMDAR2C Summary This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Expression Biased expression in thyroid (RPKM 3.2), brain (RPKM 2.5) and 6 other tissues See more Orthologs mouse all
GRIN2D, Official Symbol GRIN2Dprovided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit 2Dprovided by HGNC Primary source HGNC:HGNC:4588 See related Ensembl:ENSG00000105464 MIM:602717; AllianceGenome:HGNC:4588 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EB11; NR2D; DEE46; EIEE46; GluN2D; NMDAR2D Summary N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
GRIN3A, Official Symbol GRIN3Aprovided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit 3Aprovided by HGNC Primary source HGNC:HGNC:16767 See related Ensembl:ENSG00000198785 MIM:606650; AllianceGenome:HGNC:16767 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR3A; GluN3A; NMDAR-L; NMDAR3A Summary This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.0), prostate (RPKM 0.5) and 3 other tissues See more Orthologs mouse all
GRIN3B, Official Symbol GRIN3Bprovided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit 3Bprovided by HGNC Primary source HGNC:HGNC:16768 See related Ensembl:ENSG00000116032 MIM:606651; AllianceGenome:HGNC:16768 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NR3B; GluN3B Summary The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in spleen (RPKM 1.5), fat (RPKM 1.0) and 21 other tissues See more Orthologs mouse all
GRINA, Official Symbol GRINAprovided by HGNC Official Full Name glutamate ionotropic receptor NMDA type subunit associated protein 1provided by HGNC Primary source HGNC:HGNC:4589 See related Ensembl:ENSG00000178719 MIM:138251; AllianceGenome:HGNC:4589 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LFG1; HNRGW; TMBIM3; NMDARA1 Summary Predicted to enable transmembrane transporter binding activity. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 80.7), brain (RPKM 68.3) and 25 other tissues See more Orthologs mouse all
GRIP1, Official Symbol GRIP1provided by HGNC Official Full Name glutamate receptor interacting protein 1provided by HGNC Primary source HGNC:HGNC:18708 See related Ensembl:ENSG00000155974 MIM:604597; AllianceGenome:HGNC:18708 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRIP; FRASRS3 Summary This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010] Annotation information Note: GRIP1 (Gene ID: 23426) and NCOA2 (Gene ID: 10499) share the GRIP1 symbol/alias in common. GRIP1 is a widely used alternative name for nuclear receptor coactivator 2 (NCOA2), which can be confused with the official symbol for glutamate receptor-interacting protein 1 (GRIP1). [06 Jul 2018] Expression Broad expression in placenta (RPKM 1.6), skin (RPKM 1.5) and 23 other tissues See more Orthologs mouse all
GRIP2, Official Symbol GRIP2provided by HGNC Official Full Name glutamate receptor interacting protein 2provided by HGNC Primary source HGNC:HGNC:23841 See related Ensembl:ENSG00000144596 AllianceGenome:HGNC:23841 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in cytoplasm; dendritic shaft; and neuron spine. Predicted to be active in glutamatergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in heart (RPKM 7.1), spleen (RPKM 5.7) and 21 other tissues See more Orthologs mouse all
GRIPAP1, Official Symbol GRIPAP1provided by HGNC Official Full Name GRIP1 associated protein 1provided by HGNC Primary source HGNC:HGNC:18706 See related Ensembl:ENSG00000068400 MIM:300408; AllianceGenome:HGNC:18706 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRASP-1 Summary This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in brain (RPKM 17.5), spleen (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
GRK1, Official Symbol GRK1provided by HGNC Official Full Name G protein-coupled receptor kinase 1provided by HGNC Primary source HGNC:HGNC:10013 See related Ensembl:ENSG00000185974 MIM:180381; AllianceGenome:HGNC:10013 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RK; RHOK; GPRK1 Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008] Annotation information Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_027140.7 and the 3' end was annotated on NT_024498.13 in NCBI s Homo sapiens Annotation Release 106. [17 Jun 2014] Annotation category: suggests misassembly Expression Low expression observed in reference dataset See more Orthologs mouse all
GRK2, Official Symbol GRK2provided by HGNC Official Full Name G protein-coupled receptor kinase 2provided by HGNC Primary source HGNC:HGNC:289 See related Ensembl:ENSG00000173020 MIM:109635; AllianceGenome:HGNC:289 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BARK1; ADRBK1; BETA-ARK1 Summary This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017] Expression Broad expression in bone marrow (RPKM 91.8), spleen (RPKM 61.9) and 24 other tissues See more Orthologs mouse all
GRK3, Official Symbol GRK3provided by HGNC Official Full Name G protein-coupled receptor kinase 3provided by HGNC Primary source HGNC:HGNC:290 See related Ensembl:ENSG00000100077 MIM:109636; AllianceGenome:HGNC:290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BARK2; ADRBK2 Summary The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 17.4), spleen (RPKM 8.7) and 22 other tissues See more Orthologs mouse all
GRK4, Official Symbol GRK4provided by HGNC Official Full Name G protein-coupled receptor kinase 4provided by HGNC Primary source HGNC:HGNC:4543 See related Ensembl:ENSG00000125388 MIM:137026; AllianceGenome:HGNC:4543 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IT11; GPRK4; GRK4a; GPRK2L Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Expression Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7) See more Orthologs mouse all
GRK5, Official Symbol GRK5provided by HGNC Official Full Name G protein-coupled receptor kinase 5provided by HGNC Primary source HGNC:HGNC:4544 See related Ensembl:ENSG00000198873 MIM:600870; AllianceGenome:HGNC:4544 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPRK5; FP2025 Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues See more Orthologs mouse all
GRK6, Official Symbol GRK6provided by HGNC Official Full Name G protein-coupled receptor kinase 6provided by HGNC Primary source HGNC:HGNC:4545 See related Ensembl:ENSG00000198055 MIM:600869; AllianceGenome:HGNC:4545 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPRK6 Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 27.2), lymph node (RPKM 19.5) and 23 other tissues See more Orthologs mouse all
GRK7, Official Symbol GRK7provided by HGNC Official Full Name G protein-coupled receptor kinase 7provided by HGNC Primary source HGNC:HGNC:17031 See related Ensembl:ENSG00000114124 MIM:606987; AllianceGenome:HGNC:17031 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPRK7 Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all