psui3905/ncbi_genes_summary huggingface dataset:
CTSL, Official Symbol CTSLprovided by HGNC Official Full Name cathepsin Lprovided by HGNC Primary source HGNC:HGNC:2537 See related Ensembl:ENSG00000135047 MIM:116880; AllianceGenome:HGNC:2537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEP; CATL; CTSL1 Summary The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Broad expression in placenta (RPKM 162.6), kidney (RPKM 60.4) and 23 other tissues See more Orthologs all
CTSL3P, Official Symbol CTSL3Pprovided by HGNC Official Full Name cathepsin L family member 3, pseudogeneprovided by HGNC Primary source HGNC:HGNC:33132 See related Ensembl:ENSG00000290757 AllianceGenome:HGNC:33132 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTSL3; HCTSL-s Summary Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
CTSLP1, Official Symbol CTSLP1provided by HGNC Official Full Name cathepsin L pseudogene 1provided by HGNC Primary source HGNC:HGNC:2539 See related AllianceGenome:HGNC:2539 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTSLL; CTSLL1; CTSL1P1
CTSLP3, Official Symbol CTSLP3provided by HGNC Official Full Name cathepsin L pseudogene 3provided by HGNC Primary source HGNC:HGNC:2541 See related Ensembl:ENSG00000280913 AllianceGenome:HGNC:2541 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTSLL3; CTSL1P3
CTSLP4, Official Symbol CTSLP4provided by HGNC Official Full Name cathepsin L pseudogene 4provided by HGNC Primary source HGNC:HGNC:23645 See related AllianceGenome:HGNC:23645 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTSLL4; CTSL1P4; bA564C4.3
CTSO, Official Symbol CTSOprovided by HGNC Official Full Name cathepsin Oprovided by HGNC Primary source HGNC:HGNC:2542 See related Ensembl:ENSG00000256043 MIM:600550; AllianceGenome:HGNC:2542 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTSO1 Summary The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in gall bladder (RPKM 28.4), liver (RPKM 26.2) and 25 other tissues See more Orthologs mouse all
CTSS, Official Symbol CTSSprovided by HGNC Official Full Name cathepsin Sprovided by HGNC Primary source HGNC:HGNC:2545 See related Ensembl:ENSG00000163131 MIM:116845; AllianceGenome:HGNC:2545 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Broad expression in spleen (RPKM 89.0), appendix (RPKM 75.4) and 18 other tissues See more Orthologs mouse all
CTSV, Official Symbol CTSVprovided by HGNC Official Full Name cathepsin Vprovided by HGNC Primary source HGNC:HGNC:2538 See related Ensembl:ENSG00000136943 MIM:603308; AllianceGenome:HGNC:2538 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTSU; CATL2; CTSL2 Summary The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011] Expression Biased expression in testis (RPKM 18.5), skin (RPKM 8.5) and 3 other tissues See more Orthologs mouse all
CTSW, Official Symbol CTSWprovided by HGNC Official Full Name cathepsin Wprovided by HGNC Primary source HGNC:HGNC:2546 See related Ensembl:ENSG00000172543 MIM:602364; AllianceGenome:HGNC:2546 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYPN Summary The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 42.0), spleen (RPKM 24.6) and 12 other tissues See more Orthologs mouse all
CTSZ, Official Symbol CTSZprovided by HGNC Official Full Name cathepsin Zprovided by HGNC Primary source HGNC:HGNC:2547 See related Ensembl:ENSG00000101160 MIM:603169; AllianceGenome:HGNC:2547 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTSX Summary The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in lymph node (RPKM 146.3), appendix (RPKM 144.2) and 25 other tissues See more Orthologs mouse all
CTTN, Official Symbol CTTNprovided by HGNC Official Full Name cortactinprovided by HGNC Primary source HGNC:HGNC:3338 See related Ensembl:ENSG00000085733 MIM:164765; AllianceGenome:HGNC:3338 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EMS1 Summary This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] Expression Ubiquitous expression in gall bladder (RPKM 41.5), adrenal (RPKM 38.4) and 25 other tissues See more Orthologs mouse all
CTTNBP2, Official Symbol CTTNBP2provided by HGNC Official Full Name cortactin binding protein 2provided by HGNC Primary source HGNC:HGNC:15679 See related Ensembl:ENSG00000077063 MIM:609772; AllianceGenome:HGNC:15679 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Orf4; C7orf8; CORTBP2 Summary This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 5.1), esophagus (RPKM 3.1) and 19 other tissues See more Orthologs mouse all
CTTNBP2NL, Official Symbol CTTNBP2NLprovided by HGNC Official Full Name CTTNBP2 N-terminal likeprovided by HGNC Primary source HGNC:HGNC:25330 See related Ensembl:ENSG00000143079 MIM:615100; AllianceGenome:HGNC:25330 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables protein phosphatase 2A binding activity. Acts upstream of or within negative regulation of transmembrane transport; negative regulation of transporter activity; and protein dephosphorylation. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 9.4), gall bladder (RPKM 9.0) and 23 other tissues See more Orthologs mouse all
CTU1, Official Symbol CTU1provided by HGNC Official Full Name cytosolic thiouridylase subunit 1provided by HGNC Primary source HGNC:HGNC:29590 See related Ensembl:ENSG00000142544 MIM:612694; AllianceGenome:HGNC:29590 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCS6; ATPBD3 Summary Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 1.5), spleen (RPKM 1.3) and 25 other tissues See more Orthologs mouse all
CTU2, Official Symbol CTU2provided by HGNC Official Full Name cytosolic thiouridylase subunit 2provided by HGNC Primary source HGNC:HGNC:28005 See related Ensembl:ENSG00000174177 MIM:617057; AllianceGenome:HGNC:28005 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MFRG; NCS2; UPF0432; C16orf84 Summary This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in testis (RPKM 3.9), brain (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
CTXN1, Official Symbol CTXN1provided by HGNC Official Full Name cortexin 1provided by HGNC Primary source HGNC:HGNC:31108 See related Ensembl:ENSG00000178531 MIM:600135; AllianceGenome:HGNC:31108 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTXN Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 30.2), endometrium (RPKM 9.4) and 3 other tissues See more Orthologs mouse all
CTXN2, Official Symbol CTXN2provided by HGNC Official Full Name cortexin 2provided by HGNC Primary source HGNC:HGNC:31109 See related Ensembl:ENSG00000233932 AllianceGenome:HGNC:31109 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
CTXN3, Official Symbol CTXN3provided by HGNC Official Full Name cortexin 3provided by HGNC Primary source HGNC:HGNC:31110 See related Ensembl:ENSG00000205279 MIM:618746; AllianceGenome:HGNC:31110 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KABE Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward kidney (RPKM 21.3) See more Orthologs mouse all
CTXND1, Official Symbol CTXND1provided by HGNC Official Full Name cortexin domain containing 1provided by HGNC Primary source HGNC:HGNC:50507 See related Ensembl:ENSG00000259417 AllianceGenome:HGNC:50507 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01314 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 1.2), brain (RPKM 0.8) and 10 other tissues See more Orthologs mouse all
CTXND2, Official Symbol CTXND2provided by HGNC Official Full Name cortexin domain containing 2provided by HGNC Primary source HGNC:HGNC:53440 See related Ensembl:ENSG00000283324 AllianceGenome:HGNC:53440 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
CUBN, Official Symbol CUBNprovided by HGNC Official Full Name cubilinprovided by HGNC Primary source HGNC:HGNC:2548 See related Ensembl:ENSG00000107611 MIM:602997; AllianceGenome:HGNC:2548 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGS; IFCR; IGS1; MGA1; gp280 Summary Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 65.4) and small intestine (RPKM 9.4) See more Orthologs mouse all
CUBNP1, Official Symbol CUBNP1provided by HGNC Official Full Name cubilin pseudogene 1provided by HGNC Primary source HGNC:HGNC:44983 See related Ensembl:ENSG00000231009 AllianceGenome:HGNC:44983 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CUBNP2, Official Symbol CUBNP2provided by HGNC Official Full Name cubilin pseudogene 2provided by HGNC Primary source HGNC:HGNC:44984 See related Ensembl:ENSG00000234993 AllianceGenome:HGNC:44984 Gene type pseudo RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CUBNP3, Official Symbol CUBNP3provided by HGNC Official Full Name cubilin pseudogene 3provided by HGNC Primary source HGNC:HGNC:44985 See related Ensembl:ENSG00000235690 AllianceGenome:HGNC:44985 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CUEDC1, Official Symbol CUEDC1provided by HGNC Official Full Name CUE domain containing 1provided by HGNC Primary source HGNC:HGNC:31350 See related Ensembl:ENSG00000180891 AllianceGenome:HGNC:31350 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 6.5), brain (RPKM 6.5) and 25 other tissues See more Orthologs mouse all
CUEDC2, Official Symbol CUEDC2provided by HGNC Official Full Name CUE domain containing 2provided by HGNC Primary source HGNC:HGNC:28352 See related Ensembl:ENSG00000107874 MIM:614142; AllianceGenome:HGNC:28352 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C10orf66; bA18I14.5 Summary Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Located in cytosol; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 31.2), heart (RPKM 24.6) and 25 other tissues See more Orthologs mouse all
CUL1, Official Symbol CUL1provided by HGNC Official Full Name cullin 1provided by HGNC Primary source HGNC:HGNC:2551 See related Ensembl:ENSG00000055130 MIM:603134; AllianceGenome:HGNC:2551 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues See more Orthologs mouse all
CUL1P1, Official Symbol CUL1P1provided by HGNC Official Full Name cullin 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49567 See related AllianceGenome:HGNC:49567 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CUL2, Official Symbol CUL2provided by HGNC Official Full Name cullin 2provided by HGNC Primary source HGNC:HGNC:2552 See related Ensembl:ENSG00000108094 MIM:603135; AllianceGenome:HGNC:2552 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
CUL3, Official Symbol CUL3provided by HGNC Official Full Name cullin 3provided by HGNC Primary source HGNC:HGNC:2553 See related Ensembl:ENSG00000036257 MIM:603136; AllianceGenome:HGNC:2553 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CUL-3; PHA2E; NEDAUS Summary This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] Expression Broad expression in testis (RPKM 53.6), esophagus (RPKM 12.6) and 24 other tissues See more Orthologs mouse all
CUL4A, Official Symbol CUL4Aprovided by HGNC Official Full Name cullin 4Aprovided by HGNC Primary source HGNC:HGNC:2554 See related Ensembl:ENSG00000139842 MIM:603137; AllianceGenome:HGNC:2554 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009] Expression Ubiquitous expression in testis (RPKM 20.5), heart (RPKM 17.9) and 25 other tissues See more Orthologs mouse all
CUL4B, Official Symbol CUL4Bprovided by HGNC Official Full Name cullin 4Bprovided by HGNC Primary source HGNC:HGNC:2555 See related Ensembl:ENSG00000158290 MIM:300304; AllianceGenome:HGNC:2555 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFM2; MRXSC; CUL-4B; MRXHF2; MRXS15 Summary This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.5), ovary (RPKM 14.3) and 25 other tissues See more Orthologs mouse all
CUL5, Official Symbol CUL5provided by HGNC Official Full Name cullin 5provided by HGNC Primary source HGNC:HGNC:2556 See related Ensembl:ENSG00000166266 MIM:601741; AllianceGenome:HGNC:2556 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CUL-5; VACM1; VACM-1 Summary Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within cerebral cortex radially oriented cell migration and radial glia guided migration of Purkinje cell. Located in site of DNA damage. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 9.9), kidney (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
CUL7, Official Symbol CUL7provided by HGNC Official Full Name cullin 7provided by HGNC Primary source HGNC:HGNC:21024 See related Ensembl:ENSG00000044090 MIM:609577; AllianceGenome:HGNC:21024 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 3M1; CUL-7; KIAA0076; dJ20C7.5 Summary The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in ovary (RPKM 10.5), thyroid (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
CUL9, Official Symbol CUL9provided by HGNC Official Full Name cullin 9provided by HGNC Primary source HGNC:HGNC:15982 See related Ensembl:ENSG00000112659 MIM:607489; AllianceGenome:HGNC:15982 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARC; H7AP1 Summary Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and ubiquitin protein ligase binding activity. Involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Located in cytosol. Part of cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.1), skin (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
CUPIN1P, Official Symbol CUPIN1Pprovided by HGNC Official Full Name cupin superfamily member 1, pseudogeneprovided by HGNC Primary source HGNC:HGNC:54490 See related Ensembl:ENSG00000283613 AllianceGenome:HGNC:54490 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CUTA, Official Symbol CUTAprovided by HGNC Official Full Name cutA divalent cation tolerance homologprovided by HGNC Primary source HGNC:HGNC:21101 See related Ensembl:ENSG00000112514 MIM:616953; AllianceGenome:HGNC:21101 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACHAP; C6orf82 Summary Enables enzyme binding activity. Involved in protein localization. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 52.9), adrenal (RPKM 52.0) and 25 other tissues See more Orthologs mouse all
CUTALP, Official Symbol CUTALPprovided by HGNC Official Full Name cutA divalent cation tolerance like, pseudogeneprovided by HGNC Primary source HGNC:HGNC:27367 See related Ensembl:ENSG00000226752 AllianceGenome:HGNC:27367 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSMD5-AS1 Expression Ubiquitous expression in lymph node (RPKM 7.2), prostate (RPKM 6.8) and 25 other tissues See more
CUTC, Official Symbol CUTCprovided by HGNC Official Full Name cutC copper transporterprovided by HGNC Primary source HGNC:HGNC:24271 See related Ensembl:ENSG00000119929 MIM:610101; AllianceGenome:HGNC:24271 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-32 Summary Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 21.2), fat (RPKM 18.2) and 25 other tissues See more Orthologs mouse all
CUX1, Official Symbol CUX1provided by HGNC Official Full Name cut like homeobox 1provided by HGNC Primary source HGNC:HGNC:2557 See related Ensembl:ENSG00000257923 MIM:116896; AllianceGenome:HGNC:2557 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDP; CUX; p75; CASP; CDP1; COY1; Clox; GDDI; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317 Summary The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] Expression Ubiquitous expression in endometrium (RPKM 11.3), thyroid (RPKM 8.5) and 25 other tissues See more Orthologs mouse all
CUX2, Official Symbol CUX2provided by HGNC Official Full Name cut like homeobox 2provided by HGNC Primary source HGNC:HGNC:19347 See related Ensembl:ENSG00000111249 MIM:610648; AllianceGenome:HGNC:19347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDP2; CUTL2; DEE67; EIEE67 Summary This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013] Expression Biased expression in prostate (RPKM 4.9), liver (RPKM 4.6) and 3 other tissues See more Orthologs mouse all
CUX2P1, Official Symbol CUX2P1provided by HGNC Official Full Name cut like homeobox 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:33694 See related AllianceGenome:HGNC:33694 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CUZD1, Official Symbol CUZD1provided by HGNC Official Full Name CUB and zona pellucida like domains 1provided by HGNC Primary source HGNC:HGNC:17937 See related Ensembl:ENSG00000138161 MIM:616644; AllianceGenome:HGNC:17937 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERG1; ERG-1; UO-44; ITMAP1 Summary Predicted to be involved in trypsinogen activation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward pancreas (RPKM 310.9) See more Orthologs mouse all
CWC15, Official Symbol CWC15provided by HGNC Official Full Name CWC15 spliceosome associated protein homologprovided by HGNC Primary source HGNC:HGNC:26939 See related Ensembl:ENSG00000150316 AllianceGenome:HGNC:26939 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORF5; AD002; Cwf15; C11orf5; HSPC148 Summary Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in mitochondrion and nuclear speck. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 28.4), bone marrow (RPKM 17.4) and 25 other tissues See more Orthologs mouse all
CWC22, Official Symbol CWC22provided by HGNC Official Full Name CWC22 spliceosome associated protein homologprovided by HGNC Primary source HGNC:HGNC:29322 See related Ensembl:ENSG00000163510 MIM:615186; AllianceGenome:HGNC:29322 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCM; fSAPb; EIF4GL Summary Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 9.1), thyroid (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
CWC25, Official Symbol CWC25provided by HGNC Official Full Name CWC25 spliceosome associated protein homologprovided by HGNC Primary source HGNC:HGNC:25989 See related Ensembl:ENSG00000273559 AllianceGenome:HGNC:25989 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCDC49 Summary This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012] Expression Ubiquitous expression in bone marrow (RPKM 26.7), testis (RPKM 10.6) and 24 other tissues See more Orthologs mouse all
CWC27, Official Symbol CWC27provided by HGNC Official Full Name CWC27 spliceosome associated cyclophilinprovided by HGNC Primary source HGNC:HGNC:10664 See related Ensembl:ENSG00000153015 MIM:617170; AllianceGenome:HGNC:10664 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPSKA; NY-CO-10; SDCCAG10; SDCCAG-10 Summary Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Located in nucleoplasm. Part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.3), brain (RPKM 1.8) and 25 other tissues See more Orthologs mouse all
CWF19L1, Official Symbol CWF19L1provided by HGNC Official Full Name CWF19 like cell cycle control factor 1provided by HGNC Primary source HGNC:HGNC:25613 See related Ensembl:ENSG00000095485 MIM:616120; AllianceGenome:HGNC:25613 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C19L1; hDrn1; SCAR17 Summary This gene encodes a member of the CWF19 protein family. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia-17 and mild cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in bone marrow (RPKM 8.4), testis (RPKM 8.0) and 25 other tissues See more Orthologs mouse all
CWF19L2, Official Symbol CWF19L2provided by HGNC Official Full Name CWF19 like cell cycle control factor 2provided by HGNC Primary source HGNC:HGNC:26508 See related Ensembl:ENSG00000152404 AllianceGenome:HGNC:26508 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
CWH43, Official Symbol CWH43provided by HGNC Official Full Name cell wall biogenesis 43 C-terminal homologprovided by HGNC Primary source HGNC:HGNC:26133 See related Ensembl:ENSG00000109182 MIM:618561; AllianceGenome:HGNC:26133 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CWH43-C; PGAP2IP Summary Predicted to be involved in GPI anchor biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in prostate (RPKM 20.1), skin (RPKM 10.7) and 5 other tissues See more Orthologs mouse all
CX3CL1, Official Symbol CX3CL1provided by HGNC Official Full Name C-X3-C motif chemokine ligand 1provided by HGNC Primary source HGNC:HGNC:10647 See related Ensembl:ENSG00000006210 MIM:601880; AllianceGenome:HGNC:10647 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin Summary This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017] Expression Broad expression in brain (RPKM 40.1), lung (RPKM 37.8) and 21 other tissues See more Orthologs mouse all
CX3CR1, Official Symbol CX3CR1provided by HGNC Official Full Name C-X3-C motif chemokine receptor 1provided by HGNC Primary source HGNC:HGNC:2558 See related Ensembl:ENSG00000168329 MIM:601470; AllianceGenome:HGNC:2558 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1 Summary Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] Expression Biased expression in brain (RPKM 21.4), lung (RPKM 6.4) and 12 other tissues See more Orthologs mouse all
CXADR, Official Symbol CXADRprovided by HGNC Official Full Name CXADR Ig-like cell adhesion moleculeprovided by HGNC Primary source HGNC:HGNC:2559 See related Ensembl:ENSG00000154639 MIM:602621; AllianceGenome:HGNC:2559 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAR; HCAR; CAR4/6 Summary The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011] Expression Ubiquitous expression in skin (RPKM 12.7), duodenum (RPKM 7.3) and 23 other tissues See more Orthologs mouse all
CXADRP1, Official Symbol CXADRP1provided by HGNC Official Full Name CXADR pseudogene 1provided by HGNC Primary source HGNC:HGNC:23770 See related Ensembl:ENSG00000214319 AllianceGenome:HGNC:23770 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAR; CXADRP
CXADRP2, Official Symbol CXADRP2provided by HGNC Official Full Name CXADR pseudogene 2provided by HGNC Primary source HGNC:HGNC:33973 See related AllianceGenome:HGNC:33973 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CXADRP3, Official Symbol CXADRP3provided by HGNC Official Full Name CXADR pseudogene 3provided by HGNC Primary source HGNC:HGNC:33974 See related Ensembl:ENSG00000265766 AllianceGenome:HGNC:33974 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 5.0), colon (RPKM 0.3) and 1 other tissue See more
CXCL1, Official Symbol CXCL1provided by HGNC Official Full Name C-X-C motif chemokine ligand 1provided by HGNC Primary source HGNC:HGNC:4602 See related Ensembl:ENSG00000163739 MIM:155730; AllianceGenome:HGNC:4602 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a Summary This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Biased expression in spleen (RPKM 42.1), urinary bladder (RPKM 38.5) and 12 other tissues See more Orthologs all
CXCL10, Official Symbol CXCL10provided by HGNC Official Full Name C-X-C motif chemokine ligand 10provided by HGNC Primary source HGNC:HGNC:10637 See related Ensembl:ENSG00000169245 MIM:147310; AllianceGenome:HGNC:10637 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10 Summary This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Broad expression in appendix (RPKM 54.9), lymph node (RPKM 28.7) and 14 other tissues See more Orthologs all