psui3905/ncbi_genes_summary huggingface dataset:
ACMSD, Official Symbol ACMSDprovided by HGNC Official Full Name aminocarboxymuconate semialdehyde decarboxylaseprovided by HGNC Primary source HGNC:HGNC:19288 See related Ensembl:ENSG00000153086 MIM:608889; AllianceGenome:HGNC:19288 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004] Expression Biased expression in kidney (RPKM 17.3), liver (RPKM 10.7) and 1 other tissue See more Orthologs mouse all
ACNATP, Official Symbol ACNATPprovided by HGNC Official Full Name acyl-CoA:amino acid N-acyltransferase, pseudogeneprovided by HGNC Primary source HGNC:HGNC:34504 See related Ensembl:ENSG00000227411 AllianceGenome:HGNC:34504 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAATP1
ACO1, Official Symbol ACO1provided by HGNC Official Full Name aconitase 1provided by HGNC Primary source HGNC:HGNC:117 See related Ensembl:ENSG00000122729 MIM:100880; AllianceGenome:HGNC:117 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1 Summary The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014] Expression Broad expression in fat (RPKM 69.1), kidney (RPKM 53.2) and 24 other tissues See more Orthologs mouse all
ACO2, Official Symbol ACO2provided by HGNC Official Full Name aconitase 2provided by HGNC Primary source HGNC:HGNC:118 See related Ensembl:ENSG00000100412 MIM:100850; AllianceGenome:HGNC:118 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ICRD; OCA8; OPA9; ACONM; HEL-S-284 Summary The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008] Expression Broad expression in heart (RPKM 162.7), kidney (RPKM 93.6) and 24 other tissues See more Orthologs mouse all
ACOD1, Official Symbol ACOD1provided by HGNC Official Full Name aconitate decarboxylase 1provided by HGNC Primary source HGNC:HGNC:33904 See related Ensembl:ENSG00000102794 MIM:615275; AllianceGenome:HGNC:33904 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAD; IRG1 Summary Enables aconitate decarboxylase activity. Involved in defense response; positive regulation of antimicrobial humoral response; and tolerance induction to lipopolysaccharide. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
ACOT1, Official Symbol ACOT1provided by HGNC Official Full Name acyl-CoA thioesterase 1provided by HGNC Primary source HGNC:HGNC:33128 See related Ensembl:ENSG00000184227 MIM:614313; AllianceGenome:HGNC:33128 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACH2; CTE-1; LACH2 Summary Enables acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 27.2), liver (RPKM 24.9) and 24 other tissues See more
ACOT11, Official Symbol ACOT11provided by HGNC Official Full Name acyl-CoA thioesterase 11provided by HGNC Primary source HGNC:HGNC:18156 See related Ensembl:ENSG00000162390 MIM:606803; AllianceGenome:HGNC:18156 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BFIT; THEA; THEM1; STARD14 Summary This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] Expression Biased expression in kidney (RPKM 35.3), small intestine (RPKM 20.0) and 9 other tissues See more Orthologs mouse all
ACOT12, Official Symbol ACOT12provided by HGNC Official Full Name acyl-CoA thioesterase 12provided by HGNC Primary source HGNC:HGNC:24436 See related Ensembl:ENSG00000172497 MIM:614315; AllianceGenome:HGNC:24436 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cach; THEAL; CACH-1; STARD15 Summary Enables identical protein binding activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to act upstream of or within acetyl-CoA metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 11.8) and kidney (RPKM 0.6) See more Orthologs mouse all
ACOT13, Official Symbol ACOT13provided by HGNC Official Full Name acyl-CoA thioesterase 13provided by HGNC Primary source HGNC:HGNC:20999 See related Ensembl:ENSG00000112304 MIM:615652; AllianceGenome:HGNC:20999 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HT012; THEM2; PNAS-27 Summary This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009] Expression Ubiquitous expression in kidney (RPKM 18.3), liver (RPKM 16.3) and 25 other tissues See more Orthologs mouse all
ACOT2, Official Symbol ACOT2provided by HGNC Official Full Name acyl-CoA thioesterase 2provided by HGNC Primary source HGNC:HGNC:18431 See related Ensembl:ENSG00000119673 MIM:609972; AllianceGenome:HGNC:18431 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128 Summary This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] Expression Broad expression in fat (RPKM 57.3), liver (RPKM 39.8) and 21 other tissues See more Orthologs all
ACOT4, Official Symbol ACOT4provided by HGNC Official Full Name acyl-CoA thioesterase 4provided by HGNC Primary source HGNC:HGNC:19748 See related Ensembl:ENSG00000177465 MIM:614314; AllianceGenome:HGNC:19748 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTE1B; PTE2B; PTE-Ib Summary Enables acyl-CoA hydrolase activity and succinyl-CoA hydrolase activity. Involved in carboxylic acid metabolic process; saturated monocarboxylic acid metabolic process; and succinyl-CoA metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 4.8), liver (RPKM 2.8) and 21 other tissues See more Orthologs all
ACOT6, Official Symbol ACOT6provided by HGNC Official Full Name acyl-CoA thioesterase 6provided by HGNC Primary source HGNC:HGNC:33159 See related Ensembl:ENSG00000205669 MIM:614267; AllianceGenome:HGNC:33159 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C14orf42; c14_5530 Summary Predicted to enable acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
ACOT7, Official Symbol ACOT7provided by HGNC Official Full Name acyl-CoA thioesterase 7provided by HGNC Primary source HGNC:HGNC:24157 See related Ensembl:ENSG00000097021 MIM:602587; AllianceGenome:HGNC:24157 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II Summary This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 26.5), kidney (RPKM 21.3) and 22 other tissues See more Orthologs mouse all
ACOT8, Official Symbol ACOT8provided by HGNC Official Full Name acyl-CoA thioesterase 8provided by HGNC Primary source HGNC:HGNC:15919 See related Ensembl:ENSG00000101473 MIM:608123; AllianceGenome:HGNC:15919 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III Summary The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in adrenal (RPKM 10.6), brain (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
ACOT9, Official Symbol ACOT9provided by HGNC Official Full Name acyl-CoA thioesterase 9provided by HGNC Primary source HGNC:HGNC:17152 See related Ensembl:ENSG00000123130 MIM:300862; AllianceGenome:HGNC:17152 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACATE2; CGI-16; MTACT48; MT-ACT48 Summary The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in heart (RPKM 10.2), appendix (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
ACOX1, Official Symbol ACOX1provided by HGNC Official Full Name acyl-CoA oxidase 1provided by HGNC Primary source HGNC:HGNC:119 See related Ensembl:ENSG00000161533 MIM:609751; AllianceGenome:HGNC:119 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AOX; ACOX; SCOX; MITCH; PALMCOX Summary The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 40.5), duodenum (RPKM 21.7) and 25 other tissues See more Orthologs mouse all
ACOX2, Official Symbol ACOX2provided by HGNC Official Full Name acyl-CoA oxidase 2provided by HGNC Primary source HGNC:HGNC:120 See related Ensembl:ENSG00000168306 MIM:601641; AllianceGenome:HGNC:120 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCOX; BRCOX; CBAS6; THCCox; BRCACOX Summary The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009] Expression Broad expression in liver (RPKM 44.4), kidney (RPKM 24.1) and 15 other tissues See more Orthologs mouse all
ACOX3, Official Symbol ACOX3provided by HGNC Official Full Name acyl-CoA oxidase 3, pristanoylprovided by HGNC Primary source HGNC:HGNC:121 See related Ensembl:ENSG00000087008 MIM:603402; AllianceGenome:HGNC:121 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 3.5), skin (RPKM 3.1) and 25 other tissues See more Orthologs mouse all
ACOXL, Official Symbol ACOXLprovided by HGNC Official Full Name acyl-CoA oxidase likeprovided by HGNC Primary source HGNC:HGNC:25621 See related Ensembl:ENSG00000153093 AllianceGenome:HGNC:25621 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACOX4 Summary Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
ACOXL-AS1, Official Symbol ACOXL-AS1provided by HGNC Official Full Name ACOXL antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41112 See related Ensembl:ENSG00000204581 AllianceGenome:HGNC:41112 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ACP1, Official Symbol ACP1provided by HGNC Official Full Name acid phosphatase 1provided by HGNC Primary source HGNC:HGNC:122 See related Ensembl:ENSG00000143727 MIM:171500; AllianceGenome:HGNC:122 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAAP; LMWPTP; LMW-PTP Summary The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in adrenal (RPKM 48.0), kidney (RPKM 32.6) and 25 other tissues See more Orthologs mouse all
ACP2, Official Symbol ACP2provided by HGNC Official Full Name acid phosphatase 2, lysosomalprovided by HGNC Primary source HGNC:HGNC:123 See related Ensembl:ENSG00000134575 MIM:171650; AllianceGenome:HGNC:123 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAP Summary The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017] Expression Ubiquitous expression in duodenum (RPKM 19.4), placenta (RPKM 17.1) and 25 other tissues See more Orthologs mouse all
ACP3, Official Symbol ACP3provided by HGNC Official Full Name acid phosphatase 3provided by HGNC Primary source HGNC:HGNC:125 See related Ensembl:ENSG00000014257 MIM:171790; AllianceGenome:HGNC:125 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACPP; 5'-NT; ACP-3; TM-PAP Summary This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008] Expression Restricted expression toward prostate (RPKM 1149.8) See more Orthologs mouse all
ACP4, Official Symbol ACP4provided by HGNC Official Full Name acid phosphatase 4provided by HGNC Primary source HGNC:HGNC:14376 See related Ensembl:ENSG00000142513 MIM:606362; AllianceGenome:HGNC:14376 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACPT; AI1J Summary Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
ACP5, Official Symbol ACP5provided by HGNC Official Full Name acid phosphatase 5, tartrate resistantprovided by HGNC Primary source HGNC:HGNC:124 See related Ensembl:ENSG00000102575 MIM:171640; AllianceGenome:HGNC:124 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPAP; TRAP; TRAcP; TRACP5a; TRACP5b; TrATPase Summary This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008] Expression Broad expression in lung (RPKM 55.0), kidney (RPKM 29.2) and 16 other tissues See more Orthologs mouse all
ACP6, Official Symbol ACP6provided by HGNC Official Full Name acid phosphatase 6, lysophosphatidicprovided by HGNC Primary source HGNC:HGNC:29609 See related Ensembl:ENSG00000162836 MIM:611471; AllianceGenome:HGNC:29609 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPAP; ACPL1; PACPL1 Summary This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016] Expression Ubiquitous expression in thyroid (RPKM 3.4), prostate (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
ACP7, Official Symbol ACP7provided by HGNC Official Full Name acid phosphatase 7, tartrate resistant (putative)provided by HGNC Primary source HGNC:HGNC:33781 See related Ensembl:ENSG00000183760 MIM:610490; AllianceGenome:HGNC:33781 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAPL; PAPL1 Summary Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008] Expression Biased expression in skin (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue See more Orthologs mouse all
ACR, Official Symbol ACRprovided by HGNC Official Full Name acrosinprovided by HGNC Primary source HGNC:HGNC:126 See related Ensembl:ENSG00000100312 MIM:102480; AllianceGenome:HGNC:126 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPGF87 Summary Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 44.8) See more Orthologs mouse all
ACRBP, Official Symbol ACRBPprovided by HGNC Official Full Name acrosin binding proteinprovided by HGNC Primary source HGNC:HGNC:17195 See related Ensembl:ENSG00000111644 MIM:608352; AllianceGenome:HGNC:17195 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT23; SP32; OY-TES-1 Summary The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 162.2) See more Orthologs mouse all
ACRP1, Official Symbol ACRP1provided by HGNC Official Full Name ACR pseudogene 1provided by HGNC Primary source HGNC:HGNC:54745 See related Ensembl:ENSG00000175509 AllianceGenome:HGNC:54745 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ACRV1, Official Symbol ACRV1provided by HGNC Official Full Name acrosomal vesicle protein 1provided by HGNC Primary source HGNC:HGNC:127 See related Ensembl:ENSG00000134940 MIM:102525; AllianceGenome:HGNC:127 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SP-10; SPACA2; D11S4365 Summary This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010] Expression Restricted expression toward testis (RPKM 39.8) See more Orthologs mouse all
ACSBG1, Official Symbol ACSBG1provided by HGNC Official Full Name acyl-CoA synthetase bubblegum family member 1provided by HGNC Primary source HGNC:HGNC:29567 See related Ensembl:ENSG00000103740 MIM:614362; AllianceGenome:HGNC:29567 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BG; BG1; BGM; LPD; GR-LACS Summary The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 8.4), adrenal (RPKM 6.3) and 25 other tissues See more Orthologs mouse all
ACSBG2, Official Symbol ACSBG2provided by HGNC Official Full Name acyl-CoA synthetase bubblegum family member 2provided by HGNC Primary source HGNC:HGNC:24174 See related Ensembl:ENSG00000130377 MIM:614363; AllianceGenome:HGNC:24174 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BGR; BRGL; PRTDNY3; PRTD-NY3 Summary Enables acyl-CoA hydrolase activity and arachidonate-CoA ligase activity. Acts upstream of or within fatty acid metabolic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 79.4) See more Orthologs mouse all
ACSF2, Official Symbol ACSF2provided by HGNC Official Full Name acyl-CoA synthetase family member 2provided by HGNC Primary source HGNC:HGNC:26101 See related Ensembl:ENSG00000167107 MIM:610465; AllianceGenome:HGNC:26101 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACSMW; AVYV493 Summary Enables medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 73.1), thyroid (RPKM 24.6) and 18 other tissues See more Orthologs mouse all
ACSF3, Official Symbol ACSF3provided by HGNC Official Full Name acyl-CoA synthetase family member 3provided by HGNC Primary source HGNC:HGNC:27288 See related Ensembl:ENSG00000176715 MIM:614245; AllianceGenome:HGNC:27288 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in duodenum (RPKM 1.5), lymph node (RPKM 1.5) and 25 other tissues See more Orthologs mouse all
ACSL1, Official Symbol ACSL1provided by HGNC Official Full Name acyl-CoA synthetase long chain family member 1provided by HGNC Primary source HGNC:HGNC:3569 See related Ensembl:ENSG00000151726 MIM:152425; AllianceGenome:HGNC:3569 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS1; LACS; FACL1; FACL2; LACS1; LACS2 Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Expression Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues See more Orthologs mouse all
ACSL3, Official Symbol ACSL3provided by HGNC Official Full Name acyl-CoA synthetase long chain family member 3provided by HGNC Primary source HGNC:HGNC:3570 See related Ensembl:ENSG00000123983 MIM:602371; AllianceGenome:HGNC:3570 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS3; FACL3; LACS3; LACS 3; PRO2194 Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 44.8), brain (RPKM 31.0) and 24 other tissues See more Orthologs mouse all
ACSL4, Official Symbol ACSL4provided by HGNC Official Full Name acyl-CoA synthetase long chain family member 4provided by HGNC Primary source HGNC:HGNC:3571 See related Ensembl:ENSG00000068366 MIM:300157; AllianceGenome:HGNC:3571 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS4; FACL4; LACS4; MRX63; MRX68; XLID63 Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in adrenal (RPKM 24.5), appendix (RPKM 24.0) and 25 other tissues See more Orthologs mouse all
ACSL5, Official Symbol ACSL5provided by HGNC Official Full Name acyl-CoA synthetase long chain family member 5provided by HGNC Primary source HGNC:HGNC:16526 See related Ensembl:ENSG00000197142 MIM:605677; AllianceGenome:HGNC:16526 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS2; ACS5; FACL5; DIAR13 Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in small intestine (RPKM 203.8), duodenum (RPKM 170.4) and 10 other tissues See more Orthologs mouse all
ACSL6, Official Symbol ACSL6provided by HGNC Official Full Name acyl-CoA synthetase long chain family member 6provided by HGNC Primary source HGNC:HGNC:16496 See related Ensembl:ENSG00000164398 MIM:604443; AllianceGenome:HGNC:16496 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS2; FACL6; LACS2; LACS5; LACS 6 Summary The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Biased expression in brain (RPKM 19.2), testis (RPKM 8.4) and 5 other tissues See more Orthologs mouse all
ACSL6-AS1, Official Symbol ACSL6-AS1provided by HGNC Official Full Name ACSL6 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40772 See related Ensembl:ENSG00000223548 AllianceGenome:HGNC:40772 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ACSM1, Official Symbol ACSM1provided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 1provided by HGNC Primary source HGNC:HGNC:18049 See related Ensembl:ENSG00000166743 MIM:614357; AllianceGenome:HGNC:18049 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BUCS1; MACS1 Summary Enables CoA-ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in prostate (RPKM 1.3), ovary (RPKM 1.3) and 18 other tissues See more Orthologs all
ACSM2A, Official Symbol ACSM2Aprovided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 2Aprovided by HGNC Primary source HGNC:HGNC:32017 See related Ensembl:ENSG00000183747 MIM:614358; AllianceGenome:HGNC:32017 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACSM2; A-923A4.1 Summary This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017] Expression Restricted expression toward kidney (RPKM 83.2) See more Orthologs all
ACSM2B, Official Symbol ACSM2Bprovided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 2Bprovided by HGNC Primary source HGNC:HGNC:30931 See related Ensembl:ENSG00000066813 MIM:614359; AllianceGenome:HGNC:30931 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HXMA; ACSM2; HYST1046 Summary Enables benzoate-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward kidney (RPKM 155.6) See more Orthologs all
ACSM3, Official Symbol ACSM3provided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 3provided by HGNC Primary source HGNC:HGNC:10522 See related Ensembl:ENSG00000005187 MIM:145505; AllianceGenome:HGNC:10522 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SA; SAH Summary Enables butyrate-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. Implicated in IgA glomerulonephritis. Biomarker of ulcerative colitis. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in liver (RPKM 29.1), kidney (RPKM 21.9) and 17 other tissues See more Orthologs mouse all
ACSM4, Official Symbol ACSM4provided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 4provided by HGNC Primary source HGNC:HGNC:32016 See related Ensembl:ENSG00000215009 MIM:614360; AllianceGenome:HGNC:32016 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable decanoate-CoA ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be active in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 1.5), testis (RPKM 0.7) and 14 other tissues See more Orthologs mouse all
ACSM5, Official Symbol ACSM5provided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 5provided by HGNC Primary source HGNC:HGNC:26060 See related Ensembl:ENSG00000183549 MIM:614361; AllianceGenome:HGNC:26060 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be active in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 53.9), fat (RPKM 14.6) and 1 other tissue See more Orthologs mouse all
ACSM5P1, Official Symbol ACSM5P1provided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 5 pseudogene 1provided by HGNC Primary source HGNC:HGNC:51295 See related AllianceGenome:HGNC:51295 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ACSM6, Official Symbol ACSM6provided by HGNC Official Full Name acyl-CoA synthetase medium chain family member 6provided by HGNC Primary source HGNC:HGNC:31665 See related Ensembl:ENSG00000173124 AllianceGenome:HGNC:31665 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C10orf129; bA310E22.3 Summary Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be active in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
ACSS1, Official Symbol ACSS1provided by HGNC Official Full Name acyl-CoA synthetase short chain family member 1provided by HGNC Primary source HGNC:HGNC:16091 See related Ensembl:ENSG00000154930 MIM:614355; AllianceGenome:HGNC:16091 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACAS2L; ACECS1; AceCS2L Summary This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Expression Broad expression in placenta (RPKM 70.4), duodenum (RPKM 23.0) and 24 other tissues See more Orthologs mouse all