psui3905/ncbi_genes_summary huggingface dataset:
MFSD2B, Official Symbol MFSD2Bprovided by HGNC Official Full Name MFSD2 lysolipid transporter B, sphingolipidprovided by HGNC Primary source HGNC:HGNC:37207 See related Ensembl:ENSG00000205639 MIM:617845; AllianceGenome:HGNC:37207 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLC59A2 Summary Enables sphingolipid transporter activity. Involved in lipid transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 2.9), placenta (RPKM 0.3) and 1 other tissue See more Orthologs mouse all
MFSD3, Official Symbol MFSD3provided by HGNC Official Full Name major facilitator superfamily domain containing 3provided by HGNC Primary source HGNC:HGNC:25157 See related Ensembl:ENSG00000167700 MIM:620308; AllianceGenome:HGNC:25157 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLC33A2 Summary Predicted to enable solute:proton symporter activity. Predicted to be involved in proton transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 7.9), colon (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
MFSD4A, Official Symbol MFSD4Aprovided by HGNC Official Full Name major facilitator superfamily domain containing 4Aprovided by HGNC Primary source HGNC:HGNC:25433 See related Ensembl:ENSG00000174514 MIM:620299; AllianceGenome:HGNC:25433 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MFSD4; SLC60A1; UNQ3064 Summary Predicted to enable glucose transmembrane transporter activity. Predicted to be involved in glucose transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 40.9), stomach (RPKM 37.2) and 6 other tissues See more Orthologs mouse all
MFSD4B, Official Symbol MFSD4Bprovided by HGNC Official Full Name major facilitator superfamily domain containing 4Bprovided by HGNC Primary source HGNC:HGNC:21053 See related Ensembl:ENSG00000173214 MIM:617331; AllianceGenome:HGNC:21053 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NaGLT1; SLC60A2; KIAA1919 Summary Predicted to enable glucose transmembrane transporter activity. Predicted to be involved in glucose transmembrane transport and sodium ion transport. Predicted to be located in apical plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 2.0), testis (RPKM 1.6) and 24 other tissues See more Orthologs all
MFSD4BP1, Official Symbol MFSD4BP1provided by HGNC Official Full Name major facilitator superfamily domain containing 4B pseudogene 1provided by HGNC Primary source HGNC:HGNC:50626 See related Ensembl:ENSG00000250827 AllianceGenome:HGNC:50626 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MFSD5, Official Symbol MFSD5provided by HGNC Official Full Name major facilitator superfamily domain containing 5provided by HGNC Primary source HGNC:HGNC:28156 See related Ensembl:ENSG00000182544 MIM:620345; AllianceGenome:HGNC:28156 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hsMOT2; SLC61A1 Summary Predicted to enable molybdate ion transmembrane transporter activity. Predicted to be involved in molybdate ion transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 12.9), esophagus (RPKM 11.1) and 25 other tissues See more Orthologs mouse all
MFSD6, Official Symbol MFSD6provided by HGNC Official Full Name major facilitator superfamily domain containing 6provided by HGNC Primary source HGNC:HGNC:24711 See related Ensembl:ENSG00000151690 MIM:613476; AllianceGenome:HGNC:24711 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMR2; hMMR2 Summary Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 26.0), thyroid (RPKM 22.9) and 23 other tissues See more Orthologs mouse all
MFSD6L, Official Symbol MFSD6Lprovided by HGNC Official Full Name major facilitator superfamily domain containing 6 likeprovided by HGNC Primary source HGNC:HGNC:26656 See related Ensembl:ENSG00000185156 AllianceGenome:HGNC:26656 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
MFSD8, Official Symbol MFSD8provided by HGNC Official Full Name major facilitator superfamily domain containing 8provided by HGNC Primary source HGNC:HGNC:28486 See related Ensembl:ENSG00000164073 MIM:611124; AllianceGenome:HGNC:28486 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCMD; CLN7 Summary This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in skin (RPKM 4.9), thyroid (RPKM 4.1) and 25 other tissues See more Orthologs mouse all
MFSD9, Official Symbol MFSD9provided by HGNC Official Full Name major facilitator superfamily domain containing 9provided by HGNC Primary source HGNC:HGNC:28158 See related Ensembl:ENSG00000135953 MIM:620301; AllianceGenome:HGNC:28158 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 4.6), colon (RPKM 4.2) and 25 other tissues See more Orthologs mouse all
MGA, Official Symbol MGAprovided by HGNC Official Full Name MAX dimerization protein MGAprovided by HGNC Primary source HGNC:HGNC:14010 See related Ensembl:ENSG00000174197 MIM:616061; AllianceGenome:HGNC:14010 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAD5; MXD5 Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
MGAM, Official Symbol MGAMprovided by HGNC Official Full Name maltase-glucoamylaseprovided by HGNC Primary source HGNC:HGNC:7043 See related Ensembl:ENSG00000257335 MIM:154360; AllianceGenome:HGNC:7043 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MG; MGA Summary This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008] Expression Biased expression in small intestine (RPKM 57.9), duodenum (RPKM 42.9) and 2 other tissues See more Orthologs mouse all
MGAM2, Official Symbol MGAM2provided by HGNC Official Full Name maltase-glucoamylase 2 (putative)provided by HGNC Primary source HGNC:HGNC:28101 See related Ensembl:ENSG00000257743 AllianceGenome:HGNC:28101 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 13.7), small intestine (RPKM 11.0) and 5 other tissues See more Orthologs all
MGARP, Official Symbol MGARPprovided by HGNC Official Full Name mitochondria localized glutamic acid rich proteinprovided by HGNC Primary source HGNC:HGNC:29969 See related Ensembl:ENSG00000137463 MIM:619684; AllianceGenome:HGNC:29969 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSAP; HUMMR; CESP-1; C4orf49 Summary Predicted to be involved in several processes, including axonal transport; cellular response to hormone stimulus; and protein targeting to mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in adrenal (RPKM 112.3) and ovary (RPKM 9.8) See more Orthologs mouse all
MGAT1, Official Symbol MGAT1provided by HGNC Official Full Name alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseprovided by HGNC Primary source HGNC:HGNC:7044 See related Ensembl:ENSG00000131446 MIM:160995; AllianceGenome:HGNC:7044 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GnTI; MGAT; GLCT1; GLYT1; GNT-1; GNT-I; GLCNAC-TI Summary There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 30.2), spleen (RPKM 29.9) and 25 other tissues See more Orthologs mouse all
MGAT2, Official Symbol MGAT2provided by HGNC Official Full Name alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseprovided by HGNC Primary source HGNC:HGNC:7045 See related Ensembl:ENSG00000168282 MIM:602616; AllianceGenome:HGNC:7045 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNT2; CDG2A; CDGS2; GNT-II; GLCNACTII Summary The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Annotation information Note: MGAT2 (Gene ID: 4247) and MOGAT2 (Gene ID: 80168) share the MGAT2 symbol/alias in common. MGAT2 is a widely used alternative name for monoacylglycerol O-acyltransferase 2 (MOGAT2), which can be confused with the official symbol for MGAT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase. [25 Jun 2018] Orthologs mouse all
MGAT2P2, Official Symbol MGAT2P2provided by HGNC Official Full Name MGAT2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:51243 See related AllianceGenome:HGNC:51243 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MGAT3, Official Symbol MGAT3provided by HGNC Official Full Name beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferaseprovided by HGNC Primary source HGNC:HGNC:7046 See related Ensembl:ENSG00000128268 MIM:604621; AllianceGenome:HGNC:7046 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNT3; GNT-III Summary There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 4.5), small intestine (RPKM 3.0) and 17 other tissues See more Orthologs mouse all
MGAT3-AS1, Official Symbol MGAT3-AS1provided by HGNC Official Full Name MGAT3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51356 See related Ensembl:ENSG00000227188 AllianceGenome:HGNC:51356 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TapSAKI Expression Biased expression in small intestine (RPKM 1.5), duodenum (RPKM 0.8) and 11 other tissues See more
MGAT4A, Official Symbol MGAT4Aprovided by HGNC Official Full Name alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Aprovided by HGNC Primary source HGNC:HGNC:7047 See related Ensembl:ENSG00000071073 MIM:604623; AllianceGenome:HGNC:7047 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNT-IV; GnT-4a; GNT-IVA Summary This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008] Expression Broad expression in small intestine (RPKM 18.3), colon (RPKM 13.7) and 24 other tissues See more Orthologs mouse all
MGAT4B, Official Symbol MGAT4Bprovided by HGNC Official Full Name alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Bprovided by HGNC Primary source HGNC:HGNC:7048 See related Ensembl:ENSG00000161013 MIM:604561; AllianceGenome:HGNC:7048 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNT-IV; GNT-IVB Summary This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in small intestine (RPKM 64.0), duodenum (RPKM 63.6) and 24 other tissues See more Orthologs mouse all
MGAT4C, Official Symbol MGAT4Cprovided by HGNC Official Full Name MGAT4 family member Cprovided by HGNC Primary source HGNC:HGNC:30871 See related Ensembl:ENSG00000182050 MIM:607385; AllianceGenome:HGNC:30871 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNTIVH; HGNT-IV-H Summary Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 3.6), brain (RPKM 1.8) and 3 other tissues See more Orthologs mouse all
MGAT4D, Official Symbol MGAT4Dprovided by HGNC Official Full Name MGAT4 family member Dprovided by HGNC Primary source HGNC:HGNC:43619 See related Ensembl:ENSG00000205301 MIM:610310; AllianceGenome:HGNC:43619 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GnT1IP Summary Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 7.0) See more Orthologs mouse all
MGAT4EP, Official Symbol MGAT4EPprovided by HGNC Official Full Name MGAT4 family member E, pseudogeneprovided by HGNC Primary source HGNC:HGNC:49418 See related Ensembl:ENSG00000184774 AllianceGenome:HGNC:49418 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MGAT4FP, Official Symbol MGAT4FPprovided by HGNC Official Full Name MGAT4 family member F, pseudogeneprovided by HGNC Primary source HGNC:HGNC:49419 See related AllianceGenome:HGNC:49419 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MGAT5, Official Symbol MGAT5provided by HGNC Official Full Name alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferaseprovided by HGNC Primary source HGNC:HGNC:7049 See related Ensembl:ENSG00000152127 MIM:601774; AllianceGenome:HGNC:7049 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNT-V; GNT-VA; MGAT5A; glcNAc-T V Summary The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in heart (RPKM 14.6), lymph node (RPKM 12.4) and 24 other tissues See more Orthologs mouse all
MGAT5B, Official Symbol MGAT5Bprovided by HGNC Official Full Name alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Bprovided by HGNC Primary source HGNC:HGNC:24140 See related Ensembl:ENSG00000167889 MIM:612441; AllianceGenome:HGNC:24140 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GnT-IX; GnT-VB Summary Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 5.4) and testis (RPKM 0.7) See more Orthologs mouse all
MGC15885, Gene symbol MGC15885 Gene description uncharacterized protein MGC15885 See related Ensembl:ENSG00000259458 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MGC16275, Gene symbol MGC16275 Gene description uncharacterized protein MGC16275 See related Ensembl:ENSG00000246731 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in brain (RPKM 4.2), spleen (RPKM 1.1) and 21 other tissues See more
MGC27382, Gene symbol MGC27382 Gene description uncharacterized MGC27382 See related Ensembl:ENSG00000237413 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MGC32805, Gene symbol MGC32805 Gene description uncharacterized LOC153163 See related Ensembl:ENSG00000250328 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in ovary (RPKM 2.5), endometrium (RPKM 1.8) and 15 other tissues See more
MGC4859, Gene symbol MGC4859 Gene description uncharacterized LOC79150 See related Ensembl:ENSG00000283117 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MGLL, Official Symbol MGLLprovided by HGNC Official Full Name monoglyceride lipaseprovided by HGNC Primary source HGNC:HGNC:17038 See related Ensembl:ENSG00000074416 MIM:609699; AllianceGenome:HGNC:17038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGL; HUK5; MAGL; HU-K5 Summary This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] Expression Broad expression in fat (RPKM 103.8), esophagus (RPKM 51.9) and 19 other tissues See more Orthologs mouse all
MGME1, Official Symbol MGME1provided by HGNC Official Full Name mitochondrial genome maintenance exonuclease 1provided by HGNC Primary source HGNC:HGNC:16205 See related Ensembl:ENSG00000125871 MIM:615076; AllianceGenome:HGNC:16205 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDK1; MTDPS11; C20orf72; bA504H3.4 Summary The protein encoded by this gene is a nuclear-encoded mitochondrial protein necessary for the maintenance of mitochondrial genome synthesis. The encoded protein is a RecB-type exonuclease and primarily cleaves single-stranded DNA. Defects in this gene have been associated with mitochondrial DNA depletion syndrome-11. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] Expression Ubiquitous expression in skin (RPKM 10.5), lymph node (RPKM 7.8) and 24 other tissues See more Orthologs mouse all
MGMT, Official Symbol MGMTprovided by HGNC Official Full Name O-6-methylguanine-DNA methyltransferaseprovided by HGNC Primary source HGNC:HGNC:7059 See related Ensembl:ENSG00000170430 MIM:156569; AllianceGenome:HGNC:7059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in liver (RPKM 6.2), kidney (RPKM 3.0) and 25 other tissues See more Orthologs mouse all
MGP, Official Symbol MGPprovided by HGNC Official Full Name matrix Gla proteinprovided by HGNC Primary source HGNC:HGNC:7060 See related Ensembl:ENSG00000111341 MIM:154870; AllianceGenome:HGNC:7060 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTI; GIG36; MGLAP Summary This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016] Expression Broad expression in gall bladder (RPKM 391.2), adrenal (RPKM 338.4) and 18 other tissues See more Orthologs mouse all
MGRN1, Official Symbol MGRN1provided by HGNC Official Full Name mahogunin ring finger 1provided by HGNC Primary source HGNC:HGNC:20254 See related Ensembl:ENSG00000102858 MIM:607559; AllianceGenome:HGNC:20254 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF156 Summary Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of signal transduction; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 8.9), brain (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
MGST1, Official Symbol MGST1provided by HGNC Official Full Name microsomal glutathione S-transferase 1provided by HGNC Primary source HGNC:HGNC:7061 See related Ensembl:ENSG00000008394 MIM:138330; AllianceGenome:HGNC:7061 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGST; PMAN; GST12; MGST-I Summary The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] Expression Biased expression in fat (RPKM 182.4), liver (RPKM 177.8) and 13 other tissues See more Orthologs mouse all
MGST2, Official Symbol MGST2provided by HGNC Official Full Name microsomal glutathione S-transferase 2provided by HGNC Primary source HGNC:HGNC:7063 See related Ensembl:ENSG00000085871 MIM:601733; AllianceGenome:HGNC:7063 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GST2; MGST-II Summary The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in liver (RPKM 15.9), small intestine (RPKM 13.0) and 25 other tissues See more Orthologs mouse all
MGST3, Official Symbol MGST3provided by HGNC Official Full Name microsomal glutathione S-transferase 3provided by HGNC Primary source HGNC:HGNC:7064 See related Ensembl:ENSG00000143198 MIM:604564; AllianceGenome:HGNC:7064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GST-3; GST-III Summary This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011] Expression Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues See more Orthologs mouse all
MHENCR, Official Symbol MHENCRprovided by HGNC Official Full Name melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489provided by HGNC Primary source HGNC:HGNC:53110 See related Ensembl:ENSG00000232442 AllianceGenome:HGNC:53110 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in spleen (RPKM 10.9), thyroid (RPKM 8.8) and 25 other tissues See more
MIA, Official Symbol MIAprovided by HGNC Official Full Name MIA SH3 domain containingprovided by HGNC Primary source HGNC:HGNC:7076 See related Ensembl:ENSG00000261857 MIM:601340; AllianceGenome:HGNC:7076 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIA1; CD-RAP Summary Predicted to enable growth factor activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within cell-matrix adhesion. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in stomach (RPKM 20.5), salivary gland (RPKM 4.7) and 2 other tissues See more Orthologs mouse all
MIA2, Official Symbol MIA2provided by HGNC Official Full Name MIA SH3 domain ER export factor 2provided by HGNC Primary source HGNC:HGNC:18432 See related Ensembl:ENSG00000150527 MIM:602132; AllianceGenome:HGNC:18432 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEA6; MGEA; TALI; MGEA6; CTAGE5; MGEA11 Summary This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in small intestine (RPKM 22.6), duodenum (RPKM 22.5) and 25 other tissues See more Orthologs mouse all
MIA3, Official Symbol MIA3provided by HGNC Official Full Name MIA SH3 domain ER export factor 3provided by HGNC Primary source HGNC:HGNC:24008 See related Ensembl:ENSG00000154305 MIM:613455; AllianceGenome:HGNC:24008 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077 Summary Enables cargo receptor activity. Involved in several processes, including COPII-coated vesicle cargo loading; cell migration involved in sprouting angiogenesis; and regulation of leukocyte migration. Located in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 13.9), prostate (RPKM 13.6) and 25 other tissues See more Orthologs mouse all
MIAT, Official Symbol MIATprovided by HGNC Official Full Name myocardial infarction associated transcriptprovided by HGNC Primary source HGNC:HGNC:33425 See related Ensembl:ENSG00000225783 MIM:611082; AllianceGenome:HGNC:33425 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNCR2; GOMAFU; C22orf35; LINC00066; NCRNA00066; lncRNA-MIAT Summary This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014] Expression Biased expression in brain (RPKM 36.1), adrenal (RPKM 14.9) and 11 other tissues See more Orthologs mouse all
MIB1, Official Symbol MIB1provided by HGNC Official Full Name MIB E3 ubiquitin protein ligase 1provided by HGNC Primary source HGNC:HGNC:21086 See related Ensembl:ENSG00000101752 MIM:608677; AllianceGenome:HGNC:21086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2 Summary This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in thyroid (RPKM 7.2), endometrium (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
MIB2, Official Symbol MIB2provided by HGNC Official Full Name MIB E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:30577 See related Ensembl:ENSG00000197530 MIM:611141; AllianceGenome:HGNC:30577 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZZZ5; ZZANK1 Summary The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in spleen (RPKM 6.7), fat (RPKM 5.7) and 25 other tissues See more Orthologs mouse all
MICA, Official Symbol MICAprovided by HGNC Official Full Name MHC class I polypeptide-related sequence Aprovided by HGNC Primary source HGNC:HGNC:7090 See related Ensembl:ENSG00000204520 IMGT/GENE-DB:MICA; MIM:600169; AllianceGenome:HGNC:7090 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIC-A; PERB11.1 Summary This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in lung (RPKM 8.7), endometrium (RPKM 7.4) and 25 other tissues See more Orthologs all
MICAL1, Official Symbol MICAL1provided by HGNC Official Full Name microtubule associated monooxygenase, calponin and LIM domain containing 1provided by HGNC Primary source HGNC:HGNC:20619 See related Ensembl:ENSG00000135596 MIM:607129; AllianceGenome:HGNC:20619 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MICAL; NICAL; MICAL-1 Summary This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] Expression Ubiquitous expression in bone marrow (RPKM 31.4), lymph node (RPKM 25.8) and 23 other tissues See more Orthologs mouse all
MICAL2, Official Symbol MICAL2provided by HGNC Official Full Name microtubule associated monooxygenase, calponin and LIM domain containing 2provided by HGNC Primary source HGNC:HGNC:24693 See related Ensembl:ENSG00000133816 MIM:608881; AllianceGenome:HGNC:24693 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MICAL-2; MICALCL; Ebitein1; mical-cL; MICAL2PV1; MICAL2PV2 Summary The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016] Expression Broad expression in testis (RPKM 23.1), colon (RPKM 17.9) and 24 other tissues See more Orthologs mouse all
MICAL3, Official Symbol MICAL3provided by HGNC Official Full Name microtubule associated monooxygenase, calponin and LIM domain containing 3provided by HGNC Primary source HGNC:HGNC:24694 See related Ensembl:ENSG00000243156 MIM:608882; AllianceGenome:HGNC:24694 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MICAL-3 Summary Enables actin binding activity. Involved in actin filament depolymerization. Located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 5.1), brain (RPKM 4.5) and 25 other tissues See more Orthologs mouse all
MICALL1, Official Symbol MICALL1provided by HGNC Official Full Name MICAL like 1provided by HGNC Primary source HGNC:HGNC:29804 See related Ensembl:ENSG00000100139 MIM:619563; AllianceGenome:HGNC:29804 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIRAB13; MICAL-L1 Summary Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
MICALL2, Official Symbol MICALL2provided by HGNC Official Full Name MICAL like 2provided by HGNC Primary source HGNC:HGNC:29672 See related Ensembl:ENSG00000164877 AllianceGenome:HGNC:29672 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JRAB; MICAL-L2 Summary Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; neuron projection; and recycling endosome. Predicted to colocalize with stress fiber. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 13.4), small intestine (RPKM 10.9) and 23 other tissues See more Orthologs mouse all