psui3905/ncbi_genes_summary huggingface dataset:
ONECUT3, Official Symbol ONECUT3provided by HGNC Official Full Name one cut homeobox 3provided by HGNC Primary source HGNC:HGNC:13399 See related Ensembl:ENSG00000205922 MIM:611294; AllianceGenome:HGNC:13399 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OC3 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in stomach (RPKM 1.8) and duodenum (RPKM 0.1) See more Orthologs mouse all
OOEP, Official Symbol OOEPprovided by HGNC Official Full Name oocyte expressed proteinprovided by HGNC Primary source HGNC:HGNC:21382 See related Ensembl:ENSG00000203907 MIM:611689; AllianceGenome:HGNC:21382 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KHDC2; FLOPED; HOEP19; C6orf156 Summary Predicted to enable RNA binding activity. Predicted to be involved in several processes, including cytoskeleton organization; positive regulation of double-strand break repair via homologous recombination; and positive regulation of meiotic nuclear division. Predicted to act upstream of or within several processes, including embryo implantation; in utero embryonic development; and protein phosphorylation. Located in cytoplasm and nucleus. Part of subcortical maternal complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 5.4), placenta (RPKM 0.5) and 1 other tissue See more Orthologs mouse all
OOEP-AS1, Official Symbol OOEP-AS1provided by HGNC Official Full Name OOEP antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39192 See related Ensembl:ENSG00000231332 AllianceGenome:HGNC:39192 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OOEP-AS Expression Low expression observed in reference dataset See more
OOEPP2, Official Symbol OOEPP2provided by HGNC Official Full Name OOEP pseudogene 2provided by HGNC Primary source HGNC:HGNC:54934 See related Ensembl:ENSG00000256192 AllianceGenome:HGNC:54934 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OOSP1, Official Symbol OOSP1provided by HGNC Official Full Name oocyte secreted protein 1provided by HGNC Primary source HGNC:HGNC:49233 See related Ensembl:ENSG00000284873 AllianceGenome:HGNC:49233 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
OOSP1P1, Official Symbol OOSP1P1provided by HGNC Official Full Name oocyte secreted protein 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49240 See related Ensembl:ENSG00000238037 AllianceGenome:HGNC:49240 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OOSP1P2, Official Symbol OOSP1P2provided by HGNC Official Full Name oocyte secreted protein 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:49241 See related AllianceGenome:HGNC:49241 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OOSP2, Official Symbol OOSP2provided by HGNC Official Full Name oocyte secreted protein 2provided by HGNC Primary source HGNC:HGNC:26699 See related Ensembl:ENSG00000149507 MIM:620263; AllianceGenome:HGNC:26699 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OOSP2A; PLAC1L; TMEM122 Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 16.1) See more Orthologs mouse all
OOSP3, Official Symbol OOSP3provided by HGNC Official Full Name oocyte secreted protein family member 3provided by HGNC Primary source HGNC:HGNC:53903 See related Ensembl:ENSG00000285231 AllianceGenome:HGNC:53903 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
OOSP4A, Official Symbol OOSP4Aprovided by HGNC Official Full Name oocyte secreted protein family member 4Aprovided by HGNC Primary source HGNC:HGNC:53904 See related Ensembl:ENSG00000285010 AllianceGenome:HGNC:53904 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
OOSP4B, Official Symbol OOSP4Bprovided by HGNC Official Full Name oocyte secreted protein family member 4Bprovided by HGNC Primary source HGNC:HGNC:53905 See related Ensembl:ENSG00000255393 AllianceGenome:HGNC:53905 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
OPA1, Official Symbol OPA1provided by HGNC Official Full Name OPA1 mitochondrial dynamin like GTPaseprovided by HGNC Primary source HGNC:HGNC:8140 See related Ensembl:ENSG00000198836 MIM:605290; AllianceGenome:HGNC:8140 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPG; NTG; MGM1; BERHS; largeG; MTDPS14 Summary The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in brain (RPKM 20.5), heart (RPKM 17.2) and 25 other tissues See more Orthologs mouse all
OPA1-AS1, Official Symbol OPA1-AS1provided by HGNC Official Full Name OPA1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40421 See related Ensembl:ENSG00000224855 AllianceGenome:HGNC:40421 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 2.1), heart (RPKM 1.9) and 25 other tissues See more
OPA3, Official Symbol OPA3provided by HGNC Official Full Name outer mitochondrial membrane lipid metabolism regulator OPA3provided by HGNC Primary source HGNC:HGNC:8142 See related Ensembl:ENSG00000125741 MIM:606580; AllianceGenome:HGNC:8142 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MGA3 Summary The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in kidney (RPKM 3.0), heart (RPKM 2.4) and 25 other tissues See more Orthologs all
OPALIN, Official Symbol OPALINprovided by HGNC Official Full Name oligodendrocytic myelin paranodal and inner loop proteinprovided by HGNC Primary source HGNC:HGNC:20707 See related Ensembl:ENSG00000197430 MIM:617200; AllianceGenome:HGNC:20707 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMP10; HTMP10; TMEM10 Summary Predicted to be involved in regulation of oligodendrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward brain (RPKM 29.7) See more Orthologs mouse all
OPCML, Official Symbol OPCMLprovided by HGNC Official Full Name opioid binding protein/cell adhesion molecule likeprovided by HGNC Primary source HGNC:HGNC:8143 See related Ensembl:ENSG00000183715 MIM:600632; AllianceGenome:HGNC:8143 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPCM; OBCAM; IGLON1 Summary This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Biased expression in brain (RPKM 9.6) and kidney (RPKM 0.2) See more Orthologs mouse all
OPCML-IT1, Official Symbol OPCML-IT1provided by HGNC Official Full Name OPCML intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41366 See related Ensembl:ENSG00000254896 AllianceGenome:HGNC:41366 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OPHN1, Official Symbol OPHN1provided by HGNC Official Full Name oligophrenin 1provided by HGNC Primary source HGNC:HGNC:8148 See related Ensembl:ENSG00000079482 MIM:300127; AllianceGenome:HGNC:8148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPN1; MRX60; MRXSBL; ARHGAP41 Summary This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 5.5), prostate (RPKM 3.3) and 21 other tissues See more Orthologs mouse all
OPLAH, Official Symbol OPLAHprovided by HGNC Official Full Name 5-oxoprolinase, ATP-hydrolysingprovided by HGNC Primary source HGNC:HGNC:8149 See related Ensembl:ENSG00000178814 MIM:614243; AllianceGenome:HGNC:8149 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPLA; OPLAHD; 5-Opase Summary The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012] Expression Broad expression in testis (RPKM 16.8), kidney (RPKM 6.8) and 20 other tissues See more Orthologs mouse all
OPN1LW, Official Symbol OPN1LWprovided by HGNC Official Full Name opsin 1, long wave sensitiveprovided by HGNC Primary source HGNC:HGNC:9936 See related Ensembl:ENSG00000102076 MIM:300822; AllianceGenome:HGNC:9936 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBP; RCP; ROP; CBBM; COD5 Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
OPN1MW, Official Symbol OPN1MWprovided by HGNC Official Full Name opsin 1, medium wave sensitiveprovided by HGNC Primary source HGNC:HGNC:4206 See related Ensembl:ENSG00000268221 MIM:300821; AllianceGenome:HGNC:4206 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBD; GCP; GOP; CBBM; COD5; OPN1MW1 Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all
OPN1MW2, Official Symbol OPN1MW2provided by HGNC Official Full Name opsin 1, medium wave sensitive 2provided by HGNC Primary source HGNC:HGNC:26952 See related Ensembl:ENSG00000166160 AllianceGenome:HGNC:26952 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GOP Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009] Expression Low expression observed in reference dataset See more
OPN1MW3, Official Symbol OPN1MW3provided by HGNC Official Full Name opsin 1, medium wave sensitive 3provided by HGNC Primary source HGNC:HGNC:51831 See related Ensembl:ENSG00000269433 AllianceGenome:HGNC:51831 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCP; GOP; OPN1MW; OPN1MW2 Summary Enables identical protein binding activity and photoreceptor activity. Involved in positive regulation of cytokinesis. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
OPN1SW, Official Symbol OPN1SWprovided by HGNC Official Full Name opsin 1, short wave sensitiveprovided by HGNC Primary source HGNC:HGNC:1012 See related Ensembl:ENSG00000128617 MIM:613522; AllianceGenome:HGNC:1012 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCP; BOP; CBT Summary This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 1.6), appendix (RPKM 1.4) and 24 other tissues See more Orthologs mouse all
OPN3, Official Symbol OPN3provided by HGNC Official Full Name opsin 3provided by HGNC Primary source HGNC:HGNC:14007 See related Ensembl:ENSG00000054277 MIM:606695; AllianceGenome:HGNC:14007 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ECPN; PPP1R116 Summary Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 19.5), lung (RPKM 11.0) and 24 other tissues See more Orthologs mouse all
OPN4, Official Symbol OPN4provided by HGNC Official Full Name opsin 4provided by HGNC Primary source HGNC:HGNC:14449 See related Ensembl:ENSG00000122375 MIM:606665; AllianceGenome:HGNC:14449 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MOP Summary Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
OPN5, Official Symbol OPN5provided by HGNC Official Full Name opsin 5provided by HGNC Primary source HGNC:HGNC:19992 See related Ensembl:ENSG00000124818 MIM:609042; AllianceGenome:HGNC:19992 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR12; GPR136; GRP136; TMEM13 Summary Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] Expression Restricted expression toward testis (RPKM 1.6) See more Orthologs mouse all
OPRD1, Official Symbol OPRD1provided by HGNC Official Full Name opioid receptor delta 1provided by HGNC Primary source HGNC:HGNC:8153 See related Ensembl:ENSG00000116329 MIM:165195; AllianceGenome:HGNC:8153 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOP; DOR; DOR1; OPRD Summary Enables G protein-coupled enkephalin receptor activity. Involved in several processes, including G protein-coupled opioid receptor signaling pathway; cellular response to hypoxia; and positive regulation of peptidyl-serine phosphorylation. Is intrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
OPRK1, Official Symbol OPRK1provided by HGNC Official Full Name opioid receptor kappa 1provided by HGNC Primary source HGNC:HGNC:8154 See related Ensembl:ENSG00000082556 MIM:165196; AllianceGenome:HGNC:8154 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1 Summary This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] Expression Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues See more Orthologs mouse all
OPRL1, Official Symbol OPRL1provided by HGNC Official Full Name opioid related nociceptin receptor 1provided by HGNC Primary source HGNC:HGNC:8155 See related Ensembl:ENSG00000125510 MIM:602548; AllianceGenome:HGNC:8155 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOP; OOR; KOR3; NOPr; OPRL; ORL1; KOR-3; NOCIR; PNOCR Summary The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] Expression Broad expression in brain (RPKM 1.7), testis (RPKM 0.9) and 14 other tissues See more Orthologs mouse all
OPRM1, Official Symbol OPRM1provided by HGNC Official Full Name opioid receptor mu 1provided by HGNC Primary source HGNC:HGNC:8156 See related Ensembl:ENSG00000112038 MIM:600018; AllianceGenome:HGNC:8156 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MOP; MOR; LMOR; MOR1; OPRM; M-OR-1 Summary This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all
OPRPN, Official Symbol OPRPNprovided by HGNC Official Full Name opiorphin prepropeptideprovided by HGNC Primary source HGNC:HGNC:17279 See related Ensembl:ENSG00000171199 MIM:608936; AllianceGenome:HGNC:17279 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPLP; PRL1; PROL1; opiorphin Summary This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] Expression Restricted expression toward salivary gland (RPKM 9.7) See more Orthologs all
OPTC, Official Symbol OPTCprovided by HGNC Official Full Name opticinprovided by HGNC Primary source HGNC:HGNC:8158 See related Ensembl:ENSG00000188770 MIM:605127; AllianceGenome:HGNC:8158 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPT Summary Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
OPTN, Official Symbol OPTNprovided by HGNC Official Full Name optineurinprovided by HGNC Primary source HGNC:HGNC:17142 See related Ensembl:ENSG00000123240 MIM:602432; AllianceGenome:HGNC:17142 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP Summary This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 52.0), adrenal (RPKM 41.0) and 25 other tissues See more Orthologs mouse all
OR10A2, Official Symbol OR10A2provided by HGNC Official Full Name olfactory receptor family 10 subfamily A member 2provided by HGNC Primary source HGNC:HGNC:8161 See related Ensembl:ENSG00000170790 AllianceGenome:HGNC:8161 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OST363; OR10A2P; OR11-82; OR11-86 Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] Orthologs all
OR10A3, Official Symbol OR10A3provided by HGNC Official Full Name olfactory receptor family 10 subfamily A member 3provided by HGNC Primary source HGNC:HGNC:8162 See related Ensembl:ENSG00000170683 AllianceGenome:HGNC:8162 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTPCRX12; HSHTPCRX12 Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] Orthologs all
OR10A4, Official Symbol OR10A4provided by HGNC Official Full Name olfactory receptor family 10 subfamily A member 4provided by HGNC Primary source HGNC:HGNC:15130 See related Ensembl:ENSG00000170782 AllianceGenome:HGNC:15130 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JCG5; OR10A4P Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] Orthologs mouse all
OR10A5, Official Symbol OR10A5provided by HGNC Official Full Name olfactory receptor family 10 subfamily A member 5provided by HGNC Primary source HGNC:HGNC:15131 See related Ensembl:ENSG00000166363 MIM:608493; AllianceGenome:HGNC:15131 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JCG6; OR10A1; OR11-403 Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] Orthologs all
OR10A6, Official Symbol OR10A6provided by HGNC Official Full Name olfactory receptor family 10 subfamily A member 6 (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:15132 See related Ensembl:ENSG00000279000 AllianceGenome:HGNC:15132 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OR11-96 Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Orthologs all
OR10A7, Official Symbol OR10A7provided by HGNC Official Full Name olfactory receptor family 10 subfamily A member 7provided by HGNC Primary source HGNC:HGNC:15329 See related Ensembl:ENSG00000179919 AllianceGenome:HGNC:15329 Gene type protein coding RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OR12-6 Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] Orthologs all
OR10AA1P, Official Symbol OR10AA1Pprovided by HGNC Official Full Name olfactory receptor family 10 subfamily AA member 1 pseudogeneprovided by HGNC Primary source HGNC:HGNC:14989 See related Ensembl:ENSG00000180409 AllianceGenome:HGNC:14989 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR10AB1P, Official Symbol OR10AB1Pprovided by HGNC Official Full Name olfactory receptor family 10 subfamily AB member 1 pseudogeneprovided by HGNC Primary source HGNC:HGNC:14804 See related Ensembl:ENSG00000176716 AllianceGenome:HGNC:14804 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR10AD1, Official Symbol OR10AD1provided by HGNC Official Full Name olfactory receptor family 10 subfamily AD member 1provided by HGNC Primary source HGNC:HGNC:14819 See related Ensembl:ENSG00000172640 AllianceGenome:HGNC:14819 Gene type protein coding RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OR12-1; OR10AD1P Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] Orthologs all
OR10AE3P, Official Symbol OR10AE3Pprovided by HGNC Official Full Name olfactory receptor family 10 subfamily AE member 3 pseudogeneprovided by HGNC Primary source HGNC:HGNC:31235 See related Ensembl:ENSG00000272837 AllianceGenome:HGNC:31235 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR10AF1P, Official Symbol OR10AF1Pprovided by HGNC Official Full Name olfactory receptor family 10 subfamily AF member 1 pseudogeneprovided by HGNC Primary source HGNC:HGNC:19606 See related Ensembl:ENSG00000255416 AllianceGenome:HGNC:19606 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR10AG1, Official Symbol OR10AG1provided by HGNC Official Full Name olfactory receptor family 10 subfamily AG member 1provided by HGNC Primary source HGNC:HGNC:19607 See related Ensembl:ENSG00000174970 AllianceGenome:HGNC:19607 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OR11-160 Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] Orthologs all
OR10AH1P, Official Symbol OR10AH1Pprovided by HGNC Official Full Name olfactory receptor family 10 subfamily AH member 1 pseudogeneprovided by HGNC Primary source HGNC:HGNC:19647 See related Ensembl:ENSG00000272595 AllianceGenome:HGNC:19647 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]