psui3905/ncbi_genes_summary huggingface dataset:
RRBP1, Official Symbol RRBP1provided by HGNC Official Full Name ribosome binding protein 1provided by HGNC Primary source HGNC:HGNC:10448 See related Ensembl:ENSG00000125844 MIM:601418; AllianceGenome:HGNC:10448 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RRp; hES; p180; ES130; ES/130 Summary This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in thyroid (RPKM 72.8), colon (RPKM 63.4) and 25 other tissues See more Orthologs mouse all
RREB1, Official Symbol RREB1provided by HGNC Official Full Name ras responsive element binding protein 1provided by HGNC Primary source HGNC:HGNC:10449 See related Ensembl:ENSG00000124782 MIM:602209; AllianceGenome:HGNC:10449 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNT; FINB; LZ321; Zep-1; RREB-1 Summary The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in bone marrow (RPKM 4.1), colon (RPKM 3.6) and 25 other tissues See more Orthologs mouse all
RRH, Official Symbol RRHprovided by HGNC Official Full Name retinal pigment epithelium-derived rhodopsin homologprovided by HGNC Primary source HGNC:HGNC:10450 See related Ensembl:ENSG00000180245 MIM:605224; AllianceGenome:HGNC:10450 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled receptor. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
RRM1, Official Symbol RRM1provided by HGNC Official Full Name ribonucleotide reductase catalytic subunit M1provided by HGNC Primary source HGNC:HGNC:10451 See related Ensembl:ENSG00000167325 MIM:180410; AllianceGenome:HGNC:10451 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R1; RR1; RIR1 Summary This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in skin (RPKM 18.5), lymph node (RPKM 18.3) and 25 other tissues See more Orthologs mouse all
RRM2, Official Symbol RRM2provided by HGNC Official Full Name ribonucleotide reductase regulatory subunit M2provided by HGNC Primary source HGNC:HGNC:10452 See related Ensembl:ENSG00000171848 MIM:180390; AllianceGenome:HGNC:10452 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R2; RR2; RR2M; C2orf48 Summary This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] Expression Biased expression in bone marrow (RPKM 28.1), lymph node (RPKM 20.5) and 13 other tissues See more Orthologs mouse all
RRM2B, Official Symbol RRM2Bprovided by HGNC Official Full Name ribonucleotide reductase regulatory TP53 inducible subunit M2Bprovided by HGNC Primary source HGNC:HGNC:17296 See related Ensembl:ENSG00000048392 MIM:604712; AllianceGenome:HGNC:17296 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P53R2; RCDFRD; MTDPS8A; MTDPS8B Summary This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] Expression Ubiquitous expression in thyroid (RPKM 25.9), adrenal (RPKM 13.2) and 25 other tissues See more Orthologs mouse all
RRM2P2, Official Symbol RRM2P2provided by HGNC Official Full Name ribonucleotide reductase M2 polypeptide pseudogene 2provided by HGNC Primary source HGNC:HGNC:10454 See related Ensembl:ENSG00000236484 AllianceGenome:HGNC:10454 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RRM2P4, Official Symbol RRM2P4provided by HGNC Official Full Name ribonucleotide reductase M2 polypeptide pseudogene 4provided by HGNC Primary source HGNC:HGNC:10456 See related Ensembl:ENSG00000235598 AllianceGenome:HGNC:10456 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RRN3, Official Symbol RRN3provided by HGNC Official Full Name RRN3 homolog, RNA polymerase I transcription factorprovided by HGNC Primary source HGNC:HGNC:30346 See related Ensembl:ENSG00000085721 MIM:605121; AllianceGenome:HGNC:30346 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIFIA; A-270G1.2 Summary Enables RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter. Predicted to act upstream of or within several processes, including DNA-templated transcription, initiation; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of transcription, DNA-templated. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 15.3), thyroid (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
RRN3P2, Official Symbol RRN3P2provided by HGNC Official Full Name RRN3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:37619 See related Ensembl:ENSG00000103472 AllianceGenome:HGNC:37619 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable RNA polymerase I core binding activity and RNA polymerase I general transcription initiation factor activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 9.9), lymph node (RPKM 6.2) and 25 other tissues See more
RRN3P4, Official Symbol RRN3P4provided by HGNC Official Full Name RRN3 pseudogene 4provided by HGNC Primary source HGNC:HGNC:54536 See related Ensembl:ENSG00000229781 AllianceGenome:HGNC:54536 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RRP1, Official Symbol RRP1provided by HGNC Official Full Name ribosomal RNA processing 1provided by HGNC Primary source HGNC:HGNC:18785 See related Ensembl:ENSG00000160214 MIM:610653; AllianceGenome:HGNC:18785 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NNP-1; NOP52; RRP1A; D21S2056E Summary The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 8.5), testis (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
RRP12, Official Symbol RRP12provided by HGNC Official Full Name ribosomal RNA processing 12 homologprovided by HGNC Primary source HGNC:HGNC:29100 See related Ensembl:ENSG00000052749 MIM:617723; AllianceGenome:HGNC:29100 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA0690 Summary Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in cytosol; nucleolus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 30.6), testis (RPKM 10.2) and 25 other tissues See more Orthologs mouse all
RRP15, Official Symbol RRP15provided by HGNC Official Full Name ribosomal RNA processing 15 homologprovided by HGNC Primary source HGNC:HGNC:24255 See related Ensembl:ENSG00000067533 MIM:611193; AllianceGenome:HGNC:24255 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-115; KIAA0507 Summary This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 2.4), fat (RPKM 2.2) and 25 other tissues See more Orthologs mouse all
RRP1B, Official Symbol RRP1Bprovided by HGNC Official Full Name ribosomal RNA processing 1Bprovided by HGNC Primary source HGNC:HGNC:23818 See related Ensembl:ENSG00000160208 MIM:610654; AllianceGenome:HGNC:23818 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Nnp1; RRP1; NNP1L; KIAA0179; PPP1R136 Summary Enables transcription coactivator activity. Involved in several processes, including cellular response to virus; positive regulation by host of viral transcription; and positive regulation of transcription by RNA polymerase II. Located in chromosome; granular component; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
RRP36, Official Symbol RRP36provided by HGNC Official Full Name ribosomal RNA processing 36provided by HGNC Primary source HGNC:HGNC:21374 See related Ensembl:ENSG00000124541 MIM:613475; AllianceGenome:HGNC:21374 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6orf153; dJ20C7.4 Summary RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]).[supplied by OMIM, Jul 2010] Expression Ubiquitous expression in appendix (RPKM 16.4), lymph node (RPKM 15.5) and 25 other tissues See more Orthologs mouse all
RRP7A, Official Symbol RRP7Aprovided by HGNC Official Full Name ribosomal RNA processing 7 homolog Aprovided by HGNC Primary source HGNC:HGNC:24286 See related Ensembl:ENSG00000189306 MIM:619449; AllianceGenome:HGNC:24286 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Rrp7; CGI-96; MCPH28; BK126B4.3 Summary Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of CURI complex and UTP-C complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 9.4), lymph node (RPKM 9.3) and 25 other tissues See more Orthologs mouse all
RRP8, Official Symbol RRP8provided by HGNC Official Full Name ribosomal RNA processing 8provided by HGNC Primary source HGNC:HGNC:29030 See related Ensembl:ENSG00000132275 MIM:615818; AllianceGenome:HGNC:29030 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NML; KIAA0409 Summary Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 2.0), lymph node (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
RRP9, Official Symbol RRP9provided by HGNC Official Full Name ribosomal RNA processing 9, U3 small nucleolar RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:16829 See related Ensembl:ENSG00000114767 MIM:620013; AllianceGenome:HGNC:16829 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as U3-55K; RNU3IP2 Summary This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in appendix (RPKM 6.7), adrenal (RPKM 6.6) and 25 other tissues See more Orthologs mouse all
RRS1, Official Symbol RRS1provided by HGNC Official Full Name ribosome biogenesis regulator 1 homologprovided by HGNC Primary source HGNC:HGNC:17083 See related Ensembl:ENSG00000179041 MIM:618311; AllianceGenome:HGNC:17083 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables 5S rRNA binding activity. Involved in several processes, including mitotic metaphase plate congression; protein localization to nucleolus; and ribosomal large subunit assembly. Located in condensed nuclear chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
RS1, Official Symbol RS1provided by HGNC Official Full Name retinoschisin 1provided by HGNC Primary source HGNC:HGNC:10457 See related Ensembl:ENSG00000102104 MIM:300839; AllianceGenome:HGNC:10457 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RS; XLRS1 Summary This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
RSAD1, Official Symbol RSAD1provided by HGNC Official Full Name radical S-adenosyl methionine domain containing 1provided by HGNC Primary source HGNC:HGNC:25634 See related Ensembl:ENSG00000136444 AllianceGenome:HGNC:25634 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HemW Summary Enables heme binding activity. Predicted to be involved in porphyrin-containing compound biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 14.5), spleen (RPKM 11.7) and 25 other tissues See more Orthologs mouse all
RSAD2, Official Symbol RSAD2provided by HGNC Official Full Name radical S-adenosyl methionine domain containing 2provided by HGNC Primary source HGNC:HGNC:30908 See related Ensembl:ENSG00000134321 MIM:607810; AllianceGenome:HGNC:30908 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAND; cig5; vig1; cig33 Summary The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to viral proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including influenza virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in spleen (RPKM 6.0), lung (RPKM 5.3) and 24 other tissues See more Orthologs mouse all
RSBN1, Official Symbol RSBN1provided by HGNC Official Full Name round spermatid basic protein 1provided by HGNC Primary source HGNC:HGNC:25642 See related Ensembl:ENSG00000081019 MIM:615858; AllianceGenome:HGNC:25642 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KDM9; ROSBIN Summary Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be involved in chromatin organization. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 3.0), ovary (RPKM 2.9) and 25 other tissues See more Orthologs mouse all
RSBN1L, Official Symbol RSBN1Lprovided by HGNC Official Full Name round spermatid basic protein 1 likeprovided by HGNC Primary source HGNC:HGNC:24765 See related Ensembl:ENSG00000187257 AllianceGenome:HGNC:24765 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 10.5), thyroid (RPKM 9.2) and 25 other tissues See more Orthologs mouse all
RSC1A1, Official Symbol RSC1A1provided by HGNC Official Full Name regulator of solute carriers 1provided by HGNC Primary source HGNC:HGNC:10458 See related Ensembl:ENSG00000215695 MIM:601966; AllianceGenome:HGNC:10458 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RS1 Summary The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015] Orthologs mouse all
RSF1, Official Symbol RSF1provided by HGNC Official Full Name remodeling and spacing factor 1provided by HGNC Primary source HGNC:HGNC:18118 See related Ensembl:ENSG00000048649 MIM:608522; AllianceGenome:HGNC:18118 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XAP8; p325; HBXAP; RSF-1 Summary This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in adrenal (RPKM 7.3), thyroid (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
RSF1-IT1, Official Symbol RSF1-IT1provided by HGNC Official Full Name RSF1 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41439 See related AllianceGenome:HGNC:41439 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RSF1-IT2, Official Symbol RSF1-IT2provided by HGNC Official Full Name RSF1 intronic transcript 2provided by HGNC Primary source HGNC:HGNC:41438 See related AllianceGenome:HGNC:41438 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
RSKR, Official Symbol RSKRprovided by HGNC Official Full Name ribosomal protein S6 kinase relatedprovided by HGNC Primary source HGNC:HGNC:26314 See related Ensembl:ENSG00000167524 AllianceGenome:HGNC:26314 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SGK494 Summary Predicted to enable protein kinase activity. Predicted to be involved in protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 3.9), brain (RPKM 1.9) and 23 other tissues See more Orthologs mouse all
RSL1D1, Official Symbol RSL1D1provided by HGNC Official Full Name ribosomal L1 domain containing 1provided by HGNC Primary source HGNC:HGNC:24534 See related Ensembl:ENSG00000171490 MIM:615874; AllianceGenome:HGNC:24534 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L12; CSIG; PBK1; UTP30 Summary Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in regulation of apoptotic process and regulation of cellular senescence. Acts upstream of or within regulation of protein localization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 45.7), lymph node (RPKM 20.2) and 25 other tissues See more Orthologs mouse all
RSL24D1, Official Symbol RSL24D1provided by HGNC Official Full Name ribosomal L24 domain containing 1provided by HGNC Primary source HGNC:HGNC:18479 See related Ensembl:ENSG00000137876 MIM:613262; AllianceGenome:HGNC:18479 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L30; RLP24; RPL24; TVAS3; RPL24L; C15orf15; HRP-L30-iso Summary This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in bone marrow (RPKM 88.8), ovary (RPKM 69.7) and 25 other tissues See more Orthologs mouse all
RSL24D1P11, Official Symbol RSL24D1P11provided by HGNC Official Full Name ribosomal L24 domain containing 1 pseudogene 11provided by HGNC Primary source HGNC:HGNC:37881 See related AllianceGenome:HGNC:37881 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RSL24D1P3, Official Symbol RSL24D1P3provided by HGNC Official Full Name ribosomal L24 domain containing 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:37883 See related Ensembl:ENSG00000231556 AllianceGenome:HGNC:37883 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RSPH1, Official Symbol RSPH1provided by HGNC Official Full Name radial spoke head component 1provided by HGNC Primary source HGNC:HGNC:12371 See related Ensembl:ENSG00000160188 MIM:609314; AllianceGenome:HGNC:12371 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT79; TSA2; RSP44; TSGA2; RSPH10A Summary This gene encodes a male meiotic metaphase chromosome-associated acidic protein. This gene is expressed in tissues with motile cilia or flagella, including the trachea, lungs, airway brushings, and testes. Mutations in this gene result in primary ciliary dyskinesia-24. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] Expression Biased expression in testis (RPKM 13.7), lung (RPKM 8.0) and 12 other tissues See more Orthologs mouse all
RSPH10B, Official Symbol RSPH10Bprovided by HGNC Official Full Name radial spoke head 10 homolog Bprovided by HGNC Primary source HGNC:HGNC:27362 See related Ensembl:ENSG00000155026 AllianceGenome:HGNC:27362 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 16.5) See more Orthologs all
RSPH10B2, Official Symbol RSPH10B2provided by HGNC Official Full Name radial spoke head 10 homolog B2provided by HGNC Primary source HGNC:HGNC:34385 See related Ensembl:ENSG00000169402 AllianceGenome:HGNC:34385 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein component of the radial spoke head in flagella and motile cilia. Eukaryotic flagella and motile cilia share a common 9 + 2 structure, in which nine peripheral microtubule doublets (MTDs) surround a central-pair of microtubules (CP), with radial spokes connecting the MTDs to the CP. The radial spoke is a multi-protein complex that works as a mechanochemical transducer between the CP and the MTDs. The radial spoke contributes to the regulation of the activity of dynein motors, and thus to flagellar motility. PMID: 22754630 provides a good review of radial spokes. [provided by RefSeq, Jul 2017] Expression Restricted expression toward testis (RPKM 17.8) See more Orthologs all
RSPH14, Official Symbol RSPH14provided by HGNC Official Full Name radial spoke head 14 homologprovided by HGNC Primary source HGNC:HGNC:13437 See related Ensembl:ENSG00000100218 MIM:605663; AllianceGenome:HGNC:13437 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RTDR1 Summary This gene encodes a protein with no known function but with slight similarity to a yeast vacuolar protein. The gene is located in a region deleted in pediatric rhabdoid tumors of the brain, kidney and soft tissues, but mutations in this gene have not been associated with the disease. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 3.7), kidney (RPKM 1.1) and 2 other tissues See more Orthologs mouse all
RSPH3, Official Symbol RSPH3provided by HGNC Official Full Name radial spoke head 3provided by HGNC Primary source HGNC:HGNC:21054 See related Ensembl:ENSG00000130363 MIM:615876; AllianceGenome:HGNC:21054 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSP3; RSHL2; CILD32; dJ111C20.1 Summary The protein encoded by this gene acts as a protein kinase A anchoring protein. Mutations in this gene cause primary ciliary dyskinesia; a disorder characterized by defects of the axoneme in motile cilia and sperm flagella. The homolog of this gene was first identified in the blue-green algae Chlamydomonas as encoding a radial spoke protein that formed a structural component of motile cilia and flagella. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in thyroid (RPKM 4.1), testis (RPKM 3.3) and 25 other tissues See more Orthologs all
RSPH4A, Official Symbol RSPH4Aprovided by HGNC Official Full Name radial spoke head component 4Aprovided by HGNC Primary source HGNC:HGNC:21558 See related Ensembl:ENSG00000111834 MIM:612647; AllianceGenome:HGNC:21558 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSHL3; CILD11; RSPH6B; dJ412I7.1 Summary This gene encodes a protein that appears to be a component the radial spoke head, as determined by homology to similar proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. Radial spokes, which are regularly spaced along cilia, sperm, and flagella axonemes, consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein. Mutations in this gene cause primary ciliary dyskinesia 1, a disease arising from dysmotility of motile cilia and sperm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Expression Biased expression in lung (RPKM 1.6), testis (RPKM 0.8) and 13 other tissues See more Orthologs mouse all
RSPH6A, Official Symbol RSPH6Aprovided by HGNC Official Full Name radial spoke head 6 homolog Aprovided by HGNC Primary source HGNC:HGNC:14241 See related Ensembl:ENSG00000104941 MIM:607548; AllianceGenome:HGNC:14241 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSP4; RSP6; RSHL1; RSPH4B Summary The protein encoded by this gene is similar to a sea urchin radial spoke head protein. Radial spoke protein complexes form part of the axoneme of eukaryotic flagella and are located between the axoneme's outer ring of doublet microtubules and central pair of microtubules. In Chlamydomonas, radial spoke proteins are thought to regulate the activity of dynein and the symmetry of flagellar bending patterns. This gene maps to a region of chromosome 19 that is linked to primary ciliary dyskinesia-2 (CILD2). [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 14.9) See more Orthologs mouse all
RSPH9, Official Symbol RSPH9provided by HGNC Official Full Name radial spoke head component 9provided by HGNC Primary source HGNC:HGNC:21057 See related Ensembl:ENSG00000172426 MIM:612648; AllianceGenome:HGNC:21057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CILD12; C6orf206; MRPS18AL1 Summary This gene encodes a protein thought to be a component of the radial spoke head in motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia 12. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010] Expression Biased expression in testis (RPKM 11.2), lung (RPKM 1.7) and 1 other tissue See more Orthologs mouse all
RSPO1, Official Symbol RSPO1provided by HGNC Official Full Name R-spondin 1provided by HGNC Primary source HGNC:HGNC:21679 See related Ensembl:ENSG00000169218 MIM:609595; AllianceGenome:HGNC:21679 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSPO; CRISTIN3 Summary This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Biased expression in endometrium (RPKM 16.2), skin (RPKM 2.3) and 5 other tissues See more Orthologs mouse all
RSPO2, Official Symbol RSPO2provided by HGNC Official Full Name R-spondin 2provided by HGNC Primary source HGNC:HGNC:28583 See related Ensembl:ENSG00000147655 MIM:610575; AllianceGenome:HGNC:28583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HHRRD; TETAMS2; CRISTIN2 Summary This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in brain (RPKM 3.8), placenta (RPKM 3.6) and 11 other tissues See more Orthologs mouse all
RSPO3, Official Symbol RSPO3provided by HGNC Official Full Name R-spondin 3provided by HGNC Primary source HGNC:HGNC:20866 See related Ensembl:ENSG00000146374 MIM:610574; AllianceGenome:HGNC:20866 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PWTSR; THSD2; CRISTIN1 Summary This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013] Expression Broad expression in endometrium (RPKM 18.7), placenta (RPKM 8.3) and 14 other tissues See more Orthologs mouse all
RSPO4, Official Symbol RSPO4provided by HGNC Official Full Name R-spondin 4provided by HGNC Primary source HGNC:HGNC:16175 See related Ensembl:ENSG00000101282 MIM:610573; AllianceGenome:HGNC:16175 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRISTIN4; C20orf182 Summary This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009] Expression Biased expression in lung (RPKM 1.4), testis (RPKM 0.6) and 7 other tissues See more Orthologs mouse all
RSPRY1, Official Symbol RSPRY1provided by HGNC Official Full Name ring finger and SPRY domain containing 1provided by HGNC Primary source HGNC:HGNC:29420 See related Ensembl:ENSG00000159579 MIM:616585; AllianceGenome:HGNC:29420 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEMDFA Summary This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015] Expression Ubiquitous expression in testis (RPKM 11.4), thyroid (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
RSRC1, Official Symbol RSRC1provided by HGNC Official Full Name arginine and serine rich coiled-coil 1provided by HGNC Primary source HGNC:HGNC:24152 See related Ensembl:ENSG00000174891 MIM:613352; AllianceGenome:HGNC:24152 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT70; BM-011; SFRS21; SRrp53 Summary This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved in both constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] Expression Ubiquitous expression in thyroid (RPKM 9.3), brain (RPKM 9.2) and 25 other tissues See more Orthologs mouse all
RSRC2, Official Symbol RSRC2provided by HGNC Official Full Name arginine and serine rich coiled-coil 2provided by HGNC Primary source HGNC:HGNC:30559 See related Ensembl:ENSG00000111011 MIM:619996; AllianceGenome:HGNC:30559 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 73.5), testis (RPKM 24.5) and 25 other tissues See more Orthologs mouse all
RSRP1, Official Symbol RSRP1provided by HGNC Official Full Name arginine and serine rich protein 1provided by HGNC Primary source HGNC:HGNC:25234 See related Ensembl:ENSG00000117616 MIM:620030; AllianceGenome:HGNC:25234 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPD014; C1orf63 Expression Ubiquitous expression in spleen (RPKM 20.3), prostate (RPKM 18.6) and 25 other tissues See more Orthologs mouse all
RSU1, Official Symbol RSU1provided by HGNC Official Full Name Ras suppressor protein 1provided by HGNC Primary source HGNC:HGNC:10464 See related Ensembl:ENSG00000148484 MIM:179555; AllianceGenome:HGNC:10464 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSP-1 Summary This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues See more Orthologs mouse all
RSU1P3, Official Symbol RSU1P3provided by HGNC Official Full Name Ras suppressor protein 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:44392 See related Ensembl:ENSG00000213659 AllianceGenome:HGNC:44392 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RTBDN, Official Symbol RTBDNprovided by HGNC Official Full Name retbindinprovided by HGNC Primary source HGNC:HGNC:30310 See related Ensembl:ENSG00000132026 MIM:609553; AllianceGenome:HGNC:30310 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene was first identified in a study of human eye tissues. The protein encoded by this gene is preferentially expressed in the retina and may play a role in binding retinoids and other carotenoids as it shares homology with riboflavin binding proteins. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012] Expression Biased expression in brain (RPKM 1.6), adrenal (RPKM 0.5) and 2 other tissues See more Orthologs mouse all
RTCA, Official Symbol RTCAprovided by HGNC Official Full Name RNA 3'-terminal phosphate cyclaseprovided by HGNC Primary source HGNC:HGNC:17981 See related Ensembl:ENSG00000137996 MIM:611286; AllianceGenome:HGNC:17981 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPC; RTC1; RTCD1 Summary This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in duodenum (RPKM 10.7), kidney (RPKM 10.6) and 25 other tissues See more Orthologs mouse all