psui3905/ncbi_genes_summary huggingface dataset:
MSS51, Official Symbol MSS51provided by HGNC Official Full Name MSS51 mitochondrial translational activatorprovided by HGNC Primary source HGNC:HGNC:21000 See related Ensembl:ENSG00000166343 MIM:614773; AllianceGenome:HGNC:21000 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZMYND17 Summary Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in heart (RPKM 4.1), skin (RPKM 1.3) and 23 other tissues See more Orthologs mouse all
MST1, Official Symbol MST1provided by HGNC Official Full Name macrophage stimulating 1provided by HGNC Primary source HGNC:HGNC:7380 See related Ensembl:ENSG00000173531 MIM:142408; AllianceGenome:HGNC:7380 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSP; HGFL; NF15S2; D3F15S2; DNF15S2 Summary The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010] Annotation information Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018] Expression Biased expression in liver (RPKM 45.2), duodenum (RPKM 24.6) and 13 other tissues See more Orthologs mouse all
MST1L, Official Symbol MST1Lprovided by HGNC Official Full Name macrophage stimulating 1 like (pseudogene)provided by HGNC Primary source HGNC:HGNC:7390 See related Ensembl:ENSG00000186715 AllianceGenome:HGNC:7390 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRF-1; MSPL7; MSTP7; MSTP9; MSPL-7; MST1P9; D1F15S1A Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of mammary gland epithelial cell proliferation and regulation of macrophage chemotaxis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 17.3), duodenum (RPKM 15.5) and 12 other tissues See more
MST1R, Official Symbol MST1Rprovided by HGNC Official Full Name macrophage stimulating 1 receptorprovided by HGNC Primary source HGNC:HGNC:7381 See related Ensembl:ENSG00000164078 MIM:600168; AllianceGenome:HGNC:7381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RON; SEA; PTK8; CD136; NPCA3; CDw136; p185-Ron Summary This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016] Expression Biased expression in skin (RPKM 17.5), stomach (RPKM 16.3) and 9 other tissues See more Orthologs mouse all
MSTN, Official Symbol MSTNprovided by HGNC Official Full Name myostatinprovided by HGNC Primary source HGNC:HGNC:4223 See related Ensembl:ENSG00000138379 MIM:601788; AllianceGenome:HGNC:4223 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDF8; MSLHP Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016] Expression Low expression observed in reference dataset See more Orthologs mouse all
MSTO1, Official Symbol MSTO1provided by HGNC Official Full Name misato mitochondrial distribution and morphology regulator 1provided by HGNC Primary source HGNC:HGNC:29678 See related Ensembl:ENSG00000125459 MIM:617619; AllianceGenome:HGNC:29678 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST; MMYAT; LST005 Summary Involved in mitochondrion distribution. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 18.6), fat (RPKM 12.3) and 25 other tissues See more Orthologs mouse all
MSX1, Official Symbol MSX1provided by HGNC Official Full Name msh homeobox 1provided by HGNC Primary source HGNC:HGNC:7391 See related Ensembl:ENSG00000163132 MIM:142983; AllianceGenome:HGNC:7391 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOX7; HYD1; ECTD3; STHAG1 Summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008] Expression Biased expression in endometrium (RPKM 10.8), fat (RPKM 4.4) and 8 other tissues See more Orthologs mouse all
MSX2, Official Symbol MSX2provided by HGNC Official Full Name msh homeobox 2provided by HGNC Primary source HGNC:HGNC:7392 See related Ensembl:ENSG00000120149 MIM:123101; AllianceGenome:HGNC:7392 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPP; MSH; PFM; CRS2; HOX8; PFM1 Summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 16.6), urinary bladder (RPKM 6.4) and 5 other tissues See more Orthologs mouse all
MT1A, Official Symbol MT1Aprovided by HGNC Official Full Name metallothionein 1Aprovided by HGNC Primary source HGNC:HGNC:7393 See related Ensembl:ENSG00000205362 MIM:156350; AllianceGenome:HGNC:7393 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MTC; MT1S; MT-1A; MT-IA Summary This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017] Expression Broad expression in liver (RPKM 10.5), adrenal (RPKM 7.7) and 15 other tissues See more Orthologs all
MT1B, Official Symbol MT1Bprovided by HGNC Official Full Name metallothionein 1Bprovided by HGNC Primary source HGNC:HGNC:7394 See related Ensembl:ENSG00000169688 MIM:156349; AllianceGenome:HGNC:7394 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MTP; MT1Q; MT-1B; MT-IB Summary The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016] Expression Biased expression in liver (RPKM 1.6), duodenum (RPKM 0.4) and 1 other tissue See more
MT1DP, Official Symbol MT1DPprovided by HGNC Official Full Name metallothionein 1D, pseudogeneprovided by HGNC Primary source HGNC:HGNC:7396 See related Ensembl:ENSG00000291095 AllianceGenome:HGNC:7396 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTM Summary Predicted to enable metal ion binding activity. Predicted to be involved in cellular response to metal ion; cellular zinc ion homeostasis; and detoxification of copper ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
MT1E, Official Symbol MT1Eprovided by HGNC Official Full Name metallothionein 1Eprovided by HGNC Primary source HGNC:HGNC:7397 See related Ensembl:ENSG00000169715 MIM:156351; AllianceGenome:HGNC:7397 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MTD; MT-1E; MT-IE Summary Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in liver (RPKM 106.4), small intestine (RPKM 103.9) and 20 other tissues See more Orthologs all
MT1F, Official Symbol MT1Fprovided by HGNC Official Full Name metallothionein 1Fprovided by HGNC Primary source HGNC:HGNC:7398 See related Ensembl:ENSG00000198417 MIM:156352; AllianceGenome:HGNC:7398 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1 Summary Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 263.0), kidney (RPKM 198.1) and 9 other tissues See more
MT1G, Official Symbol MT1Gprovided by HGNC Official Full Name metallothionein 1Gprovided by HGNC Primary source HGNC:HGNC:7399 See related Ensembl:ENSG00000125144 MIM:156353; AllianceGenome:HGNC:7399 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MT1K Summary Enables zinc ion binding activity. Involved in cellular response to metal ion; cellular response to vascular endothelial growth factor stimulus; and negative regulation of growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 963.2), thyroid (RPKM 736.8) and 7 other tissues See more Orthologs all
MT1H, Official Symbol MT1Hprovided by HGNC Official Full Name metallothionein 1Hprovided by HGNC Primary source HGNC:HGNC:7400 See related Ensembl:ENSG00000205358 MIM:156354; AllianceGenome:HGNC:7400 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MT-0; MT-1H; MT-IH Summary Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 179.8), small intestine (RPKM 88.9) and 6 other tissues See more
MT1HL1, Official Symbol MT1HL1provided by HGNC Official Full Name metallothionein 1H like 1provided by HGNC Primary source HGNC:HGNC:31864 See related Ensembl:ENSG00000244020 AllianceGenome:HGNC:31864 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1P2 Summary This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at three internal amino acids, two of which are at metal-binding sites. [provided by RefSeq, Mar 2013] Orthologs all
MT1JP, Official Symbol MT1JPprovided by HGNC Official Full Name metallothionein 1J, pseudogeneprovided by HGNC Primary source HGNC:HGNC:7402 See related Ensembl:ENSG00000290662 MIM:156356; AllianceGenome:HGNC:7402 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MTB; MT1J; MT1NP Expression Low expression observed in reference dataset See more Orthologs all
MT1M, Official Symbol MT1Mprovided by HGNC Official Full Name metallothionein 1Mprovided by HGNC Primary source HGNC:HGNC:14296 See related Ensembl:ENSG00000205364 MIM:156357; AllianceGenome:HGNC:14296 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MT1K; MT-1M; MT-IM Summary This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011] Expression Broad expression in colon (RPKM 54.9), small intestine (RPKM 40.3) and 14 other tissues See more Orthologs all
MT1P3, Official Symbol MT1P3provided by HGNC Official Full Name metallothionein 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:16120 See related Ensembl:ENSG00000229230 AllianceGenome:HGNC:16120 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTL4; C20orf127; dJ614O4.6
MT1X, Official Symbol MT1Xprovided by HGNC Official Full Name metallothionein 1Xprovided by HGNC Primary source HGNC:HGNC:7405 See related Ensembl:ENSG00000187193 MIM:156359; AllianceGenome:HGNC:7405 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT1; MT-1l Summary Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in cellular response to cadmium ion; cellular response to erythropoietin; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in liver (RPKM 301.6), kidney (RPKM 245.8) and 16 other tissues See more Orthologs all
MT2A, Official Symbol MT2Aprovided by HGNC Official Full Name metallothionein 2Aprovided by HGNC Primary source HGNC:HGNC:7406 See related Ensembl:ENSG00000125148 MIM:156360; AllianceGenome:HGNC:7406 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT2; MT-2; MT-II Summary This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017] Expression Broad expression in adrenal (RPKM 718.8), liver (RPKM 608.8) and 20 other tissues See more Orthologs mouse all
MT3, Official Symbol MT3provided by HGNC Official Full Name metallothionein 3provided by HGNC Primary source HGNC:HGNC:7408 See related Ensembl:ENSG00000087250 MIM:139255; AllianceGenome:HGNC:7408 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GIF; GIFB; GRIF; ZnMT3 Summary This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017] Annotation information Note: GIF (Gene ID: 2694) and MT3 (Gene ID: 4504) share the GIF symbol/alias in common. GIF is a widely used alternative name for metallothionein 3 (MT3), which can be confused with the official symbol for GIF (gastric intrinsic factor, GeneID 2694). [01 Jun 2018] Expression Biased expression in brain (RPKM 149.3) and adrenal (RPKM 10.1) See more Orthologs mouse all
MT4, Official Symbol MT4provided by HGNC Official Full Name metallothionein 4provided by HGNC Primary source HGNC:HGNC:18705 See related Ensembl:ENSG00000102891 MIM:606206; AllianceGenome:HGNC:18705 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT-4; MTIV; MT-IV Summary Predicted to enable metal ion binding activity. Predicted to be involved in cellular response to metal ion; cellular zinc ion homeostasis; and detoxification of copper ion. Predicted to act upstream of or within cellular metal ion homeostasis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
MTA1, Official Symbol MTA1provided by HGNC Official Full Name metastasis associated 1provided by HGNC Primary source HGNC:HGNC:7410 See related Ensembl:ENSG00000182979 MIM:603526; AllianceGenome:HGNC:7410 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in testis (RPKM 14.9), spleen (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
MTA2, Official Symbol MTA2provided by HGNC Official Full Name metastasis associated 1 family member 2provided by HGNC Primary source HGNC:HGNC:7411 See related Ensembl:ENSG00000149480 MIM:603947; AllianceGenome:HGNC:7411 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PID; MTA1L1 Summary This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011] Expression Ubiquitous expression in lymph node (RPKM 29.2), skin (RPKM 28.1) and 25 other tissues See more Orthologs mouse all
MTA3, Official Symbol MTA3provided by HGNC Official Full Name metastasis associated 1 family member 3provided by HGNC Primary source HGNC:HGNC:23784 See related Ensembl:ENSG00000057935 MIM:609050; AllianceGenome:HGNC:23784 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.3), ovary (RPKM 5.7) and 24 other tissues See more Orthologs mouse all
MTA3P1, Official Symbol MTA3P1provided by HGNC Official Full Name MTA3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54535 See related Ensembl:ENSG00000228937 AllianceGenome:HGNC:54535 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTAP, Official Symbol MTAPprovided by HGNC Official Full Name methylthioadenosine phosphorylaseprovided by HGNC Primary source HGNC:HGNC:7413 See related Ensembl:ENSG00000099810 MIM:156540; AllianceGenome:HGNC:7413 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249 Summary This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021] Expression Ubiquitous expression in ovary (RPKM 5.5), esophagus (RPKM 5.2) and 25 other tissues See more Orthologs mouse all
MTAPP2, Official Symbol MTAPP2provided by HGNC Official Full Name methylthioadenosine phosphorylase pseudogene 2provided by HGNC Primary source HGNC:HGNC:42443 See related Ensembl:ENSG00000230077 AllianceGenome:HGNC:42443 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTARC1, Official Symbol MTARC1provided by HGNC Official Full Name mitochondrial amidoxime reducing component 1provided by HGNC Primary source HGNC:HGNC:26189 See related Ensembl:ENSG00000186205 MIM:614126; AllianceGenome:HGNC:26189 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARC1; MOSC1 Summary Enables molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Contributes to nitrite reductase (NO-forming) activity. Involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 66.4), thyroid (RPKM 15.8) and 6 other tissues See more Orthologs all
MTARC2, Official Symbol MTARC2provided by HGNC Official Full Name mitochondrial amidoxime reducing component 2provided by HGNC Primary source HGNC:HGNC:26064 See related Ensembl:ENSG00000117791 MIM:614127; AllianceGenome:HGNC:26064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARC2; MOSC2 Summary The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016] Expression Broad expression in kidney (RPKM 32.4), liver (RPKM 26.8) and 23 other tissues See more Orthologs mouse all
MTATP6P1, Official Symbol MTATP6P1provided by HGNC Official Full Name MT-ATP6 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44575 See related Ensembl:ENSG00000248527 AllianceGenome:HGNC:44575 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P10, Official Symbol MTATP6P10provided by HGNC Official Full Name MT-ATP6 pseudogene 10provided by HGNC Primary source HGNC:HGNC:52056 See related Ensembl:ENSG00000283626 AllianceGenome:HGNC:52056 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P11, Official Symbol MTATP6P11provided by HGNC Official Full Name MT-ATP6 pseudogene 11provided by HGNC Primary source HGNC:HGNC:52057 See related Ensembl:ENSG00000228097 AllianceGenome:HGNC:52057 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P13, Official Symbol MTATP6P13provided by HGNC Official Full Name MT-ATP6 pseudogene 13provided by HGNC Primary source HGNC:HGNC:52058 See related Ensembl:ENSG00000229842 AllianceGenome:HGNC:52058 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P14, Official Symbol MTATP6P14provided by HGNC Official Full Name MT-ATP6 pseudogene 14provided by HGNC Primary source HGNC:HGNC:52059 See related Ensembl:ENSG00000233449 AllianceGenome:HGNC:52059 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P15, Official Symbol MTATP6P15provided by HGNC Official Full Name MT-ATP6 pseudogene 15provided by HGNC Primary source HGNC:HGNC:52060 See related Ensembl:ENSG00000254931 AllianceGenome:HGNC:52060 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P16, Official Symbol MTATP6P16provided by HGNC Official Full Name MT-ATP6 pseudogene 16provided by HGNC Primary source HGNC:HGNC:52061 See related Ensembl:ENSG00000224299 AllianceGenome:HGNC:52061 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALS2CR3
MTATP6P17, Official Symbol MTATP6P17provided by HGNC Official Full Name MT-ATP6 pseudogene 17provided by HGNC Primary source HGNC:HGNC:52062 See related Ensembl:ENSG00000235433 AllianceGenome:HGNC:52062 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P18, Official Symbol MTATP6P18provided by HGNC Official Full Name MT-ATP6 pseudogene 18provided by HGNC Primary source HGNC:HGNC:52063 See related Ensembl:ENSG00000227035 AllianceGenome:HGNC:52063 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P19, Official Symbol MTATP6P19provided by HGNC Official Full Name MT-ATP6 pseudogene 19provided by HGNC Primary source HGNC:HGNC:52064 See related Ensembl:ENSG00000228316 AllianceGenome:HGNC:52064 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P2, Official Symbol MTATP6P2provided by HGNC Official Full Name MT-ATP6 pseudogene 2provided by HGNC Primary source HGNC:HGNC:44576 See related Ensembl:ENSG00000270307 AllianceGenome:HGNC:44576 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P20, Official Symbol MTATP6P20provided by HGNC Official Full Name MT-ATP6 pseudogene 20provided by HGNC Primary source HGNC:HGNC:52176 See related Ensembl:ENSG00000237948 AllianceGenome:HGNC:52176 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P21, Official Symbol MTATP6P21provided by HGNC Official Full Name MT-ATP6 pseudogene 21provided by HGNC Primary source HGNC:HGNC:52177 See related Ensembl:ENSG00000226392 AllianceGenome:HGNC:52177 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P22, Official Symbol MTATP6P22provided by HGNC Official Full Name MT-ATP6 pseudogene 22provided by HGNC Primary source HGNC:HGNC:52178 See related Ensembl:ENSG00000249580 AllianceGenome:HGNC:52178 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P23, Official Symbol MTATP6P23provided by HGNC Official Full Name MT-ATP6 pseudogene 23provided by HGNC Primary source HGNC:HGNC:52179 See related Ensembl:ENSG00000230755 AllianceGenome:HGNC:52179 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P24, Official Symbol MTATP6P24provided by HGNC Official Full Name MT-ATP6 pseudogene 24provided by HGNC Primary source HGNC:HGNC:52180 See related Ensembl:ENSG00000262381 AllianceGenome:HGNC:52180 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P25, Official Symbol MTATP6P25provided by HGNC Official Full Name MT-ATP6 pseudogene 25provided by HGNC Primary source HGNC:HGNC:52181 See related Ensembl:ENSG00000262095 AllianceGenome:HGNC:52181 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P26, Official Symbol MTATP6P26provided by HGNC Official Full Name MT-ATP6 pseudogene 26provided by HGNC Primary source HGNC:HGNC:52182 See related Ensembl:ENSG00000236878 AllianceGenome:HGNC:52182 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P27, Official Symbol MTATP6P27provided by HGNC Official Full Name MT-ATP6 pseudogene 27provided by HGNC Primary source HGNC:HGNC:52183 See related Ensembl:ENSG00000234003 AllianceGenome:HGNC:52183 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P29, Official Symbol MTATP6P29provided by HGNC Official Full Name MT-ATP6 pseudogene 29provided by HGNC Primary source HGNC:HGNC:52187 See related Ensembl:ENSG00000232179 AllianceGenome:HGNC:52187 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P3, Official Symbol MTATP6P3provided by HGNC Official Full Name MT-ATP6 pseudogene 3provided by HGNC Primary source HGNC:HGNC:44577 See related Ensembl:ENSG00000263483 AllianceGenome:HGNC:44577 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P30, Official Symbol MTATP6P30provided by HGNC Official Full Name MT-ATP6 pseudogene 30provided by HGNC Primary source HGNC:HGNC:52185 See related Ensembl:ENSG00000226998 AllianceGenome:HGNC:52185 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P31, Official Symbol MTATP6P31provided by HGNC Official Full Name MT-ATP6 pseudogene 31provided by HGNC Primary source HGNC:HGNC:52186 See related AllianceGenome:HGNC:52186 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
MTATP6P4, Official Symbol MTATP6P4provided by HGNC Official Full Name MT-ATP6 pseudogene 4provided by HGNC Primary source HGNC:HGNC:44578 See related Ensembl:ENSG00000236590 AllianceGenome:HGNC:44578 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P5, Official Symbol MTATP6P5provided by HGNC Official Full Name MT-ATP6 pseudogene 5provided by HGNC Primary source HGNC:HGNC:44579 See related AllianceGenome:HGNC:44579 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P7, Official Symbol MTATP6P7provided by HGNC Official Full Name MT-ATP6 pseudogene 7provided by HGNC Primary source HGNC:HGNC:44581 See related Ensembl:ENSG00000232990 AllianceGenome:HGNC:44581 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P8, Official Symbol MTATP6P8provided by HGNC Official Full Name MT-ATP6 pseudogene 8provided by HGNC Primary source HGNC:HGNC:44582 See related Ensembl:ENSG00000283547 AllianceGenome:HGNC:44582 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP6P9, Official Symbol MTATP6P9provided by HGNC Official Full Name MT-ATP6 pseudogene 9provided by HGNC Primary source HGNC:HGNC:44583 See related Ensembl:ENSG00000248420 AllianceGenome:HGNC:44583 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP8P1, Official Symbol MTATP8P1provided by HGNC Official Full Name MT-ATP8 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44571 See related Ensembl:ENSG00000240409 AllianceGenome:HGNC:44571 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTATP8P2, Official Symbol MTATP8P2provided by HGNC Official Full Name MT-ATP8 pseudogene 2provided by HGNC Primary source HGNC:HGNC:44572 See related Ensembl:ENSG00000229604 AllianceGenome:HGNC:44572 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MTBP, Official Symbol MTBPprovided by HGNC Official Full Name MDM2 binding proteinprovided by HGNC Primary source HGNC:HGNC:7417 See related Ensembl:ENSG00000172167 MIM:605927; AllianceGenome:HGNC:7417 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MDM2BP Summary This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012] Expression Broad expression in testis (RPKM 2.1), lymph node (RPKM 1.4) and 24 other tissues See more Orthologs mouse all
MTCH1, Official Symbol MTCH1provided by HGNC Official Full Name mitochondrial carrier 1provided by HGNC Primary source HGNC:HGNC:17586 See related Ensembl:ENSG00000137409 MIM:610449; AllianceGenome:HGNC:17586 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSAP; PIG60; CGI-64; SLC25A49 Summary This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012] Annotation information Note: PSAP (Gene ID: 5660) and MTCH1 (Gene ID: 23787) share the PSAP symbol/alias in common. PSAP is a widely used alternative name for mitochondrial carrier 1 (MTCH1), which can be confused with the official symbol for PSAP (prosaposin, GeneID 5660). [01 Jun 2018] Expression Ubiquitous expression in thyroid (RPKM 127.6), brain (RPKM 84.7) and 25 other tissues See more Orthologs mouse all
MTCH2, Official Symbol MTCH2provided by HGNC Official Full Name mitochondrial carrier 2provided by HGNC Primary source HGNC:HGNC:17587 See related Ensembl:ENSG00000109919 MIM:613221; AllianceGenome:HGNC:17587 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIMP; HSPC032; SLC25A50 Summary This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017] Expression Ubiquitous expression in kidney (RPKM 24.0), testis (RPKM 21.8) and 25 other tissues See more Orthologs mouse all
MTCL1, Official Symbol MTCL1provided by HGNC Official Full Name microtubule crosslinking factor 1provided by HGNC Primary source HGNC:HGNC:29121 See related Ensembl:ENSG00000168502 MIM:615766; AllianceGenome:HGNC:29121 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SOGA2; CCDC165; KIAA0802 Summary Enables microtubule binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity; microtubule bundle formation; and positive regulation of protein targeting to membrane. Located in midbody and spindle pole. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 4.1), gall bladder (RPKM 3.9) and 22 other tissues See more Orthologs mouse all
MTCL1P1, Official Symbol MTCL1P1provided by HGNC Official Full Name MTCL1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:42040 See related AllianceGenome:HGNC:42040 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SOGA2P1; CCDC165P1
MTCO1P11, Official Symbol MTCO1P11provided by HGNC Official Full Name MT-CO1 pseudogene 11provided by HGNC Primary source HGNC:HGNC:52013 See related Ensembl:ENSG00000224083 AllianceGenome:HGNC:52013 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo