psui3905/ncbi_genes_summary huggingface dataset:
PRAF2, Official Symbol PRAF2provided by HGNC Official Full Name PRA1 domain family member 2provided by HGNC Primary source HGNC:HGNC:28911 See related Ensembl:ENSG00000243279 MIM:300840; AllianceGenome:HGNC:28911 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JM4; Yip6a Summary Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 27.2), testis (RPKM 14.5) and 24 other tissues See more Orthologs mouse all
PRAG1, Official Symbol PRAG1provided by HGNC Official Full Name PEAK1 related, kinase-activating pseudokinase 1provided by HGNC Primary source HGNC:HGNC:25438 See related Ensembl:ENSG00000275342 MIM:617344; AllianceGenome:HGNC:25438 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NACK; PEAK2; SGK223; PRAGMIN Summary This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014] Expression Broad expression in thyroid (RPKM 9.5), fat (RPKM 5.5) and 22 other tissues See more Orthologs mouse all
PRAM1, Official Symbol PRAM1provided by HGNC Official Full Name PML-RARA regulated adaptor molecule 1provided by HGNC Primary source HGNC:HGNC:30091 See related Ensembl:ENSG00000133246 MIM:606466; AllianceGenome:HGNC:30091 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAM-1; PML-RAR Summary The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues See more Orthologs mouse all
PRAME, Official Symbol PRAMEprovided by HGNC Official Full Name PRAME nuclear receptor transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:9336 See related Ensembl:ENSG00000185686 MIM:606021; AllianceGenome:HGNC:9336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAPE; OIP4; CT130; OIP-4 Summary This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Restricted expression toward testis (RPKM 47.0) See more Orthologs all
PRAMEF1, Official Symbol PRAMEF1provided by HGNC Official Full Name PRAME family member 1provided by HGNC Primary source HGNC:HGNC:28840 See related Ensembl:ENSG00000116721 AllianceGenome:HGNC:28840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the PRAME (preferentially expressed antigen of melanoma) gene family which is expressed in many cancers but may function in reproductive tissues during development. Alternative promoter usage generates two transcript variants, which encode different isoforms. [provided by RefSeq, Jun 2014] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF10, Official Symbol PRAMEF10provided by HGNC Official Full Name PRAME family member 10provided by HGNC Primary source HGNC:HGNC:27997 See related Ensembl:ENSG00000187545 AllianceGenome:HGNC:27997 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward liver (RPKM 6.5) See more Orthologs all
PRAMEF11, Official Symbol PRAMEF11provided by HGNC Official Full Name PRAME family member 11provided by HGNC Primary source HGNC:HGNC:14086 See related Ensembl:ENSG00000239810 AllianceGenome:HGNC:14086 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF12, Official Symbol PRAMEF12provided by HGNC Official Full Name PRAME family member 12provided by HGNC Primary source HGNC:HGNC:22125 See related Ensembl:ENSG00000116726 AllianceGenome:HGNC:22125 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF13, Official Symbol PRAMEF13provided by HGNC Official Full Name PRAME family member 13provided by HGNC Primary source HGNC:HGNC:13262 See related Ensembl:ENSG00000279169 AllianceGenome:HGNC:13262 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF14, Official Symbol PRAMEF14provided by HGNC Official Full Name PRAME family member 14provided by HGNC Primary source HGNC:HGNC:13576 See related Ensembl:ENSG00000204481 AllianceGenome:HGNC:13576 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF15, Official Symbol PRAMEF15provided by HGNC Official Full Name PRAME family member 15provided by HGNC Primary source HGNC:HGNC:26764 See related Ensembl:ENSG00000204501 AllianceGenome:HGNC:26764 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF17, Official Symbol PRAMEF17provided by HGNC Official Full Name PRAME family member 17provided by HGNC Primary source HGNC:HGNC:29485 See related Ensembl:ENSG00000204479 AllianceGenome:HGNC:29485 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF18, Official Symbol PRAMEF18provided by HGNC Official Full Name PRAME family member 18provided by HGNC Primary source HGNC:HGNC:30693 See related Ensembl:ENSG00000279804 AllianceGenome:HGNC:30693 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF19, Official Symbol PRAMEF19provided by HGNC Official Full Name PRAME family member 19provided by HGNC Primary source HGNC:HGNC:24908 See related Ensembl:ENSG00000204480 AllianceGenome:HGNC:24908 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF2, Official Symbol PRAMEF2provided by HGNC Official Full Name PRAME family member 2provided by HGNC Primary source HGNC:HGNC:28841 See related Ensembl:ENSG00000120952 AllianceGenome:HGNC:28841 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DJ845O24.3 Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF20, Official Symbol PRAMEF20provided by HGNC Official Full Name PRAME family member 20provided by HGNC Primary source HGNC:HGNC:25224 See related Ensembl:ENSG00000204478 AllianceGenome:HGNC:25224 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAMEF21 Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF25, Official Symbol PRAMEF25provided by HGNC Official Full Name PRAME family member 25provided by HGNC Primary source HGNC:HGNC:49179 See related Ensembl:ENSG00000229571 AllianceGenome:HGNC:49179 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF26, Official Symbol PRAMEF26provided by HGNC Official Full Name PRAME family member 26provided by HGNC Primary source HGNC:HGNC:49178 See related Ensembl:ENSG00000280267 AllianceGenome:HGNC:49178 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAMEF25 Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF27, Official Symbol PRAMEF27provided by HGNC Official Full Name PRAME family member 27provided by HGNC Primary source HGNC:HGNC:51234 See related Ensembl:ENSG00000274764 AllianceGenome:HGNC:51234 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be located in acrosomal vesicle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF28P, Official Symbol PRAMEF28Pprovided by HGNC Official Full Name PRAME family member 28, pseudogeneprovided by HGNC Primary source HGNC:HGNC:51890 See related Ensembl:ENSG00000274178 AllianceGenome:HGNC:51890 Gene type pseudo RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAMEF28
PRAMEF33, Official Symbol PRAMEF33provided by HGNC Official Full Name PRAME family member 33provided by HGNC Primary source HGNC:HGNC:49193 See related Ensembl:ENSG00000237700 AllianceGenome:HGNC:49193 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAMEF33P Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward liver (RPKM 5.4) See more Orthologs all
PRAMEF36P, Official Symbol PRAMEF36Pprovided by HGNC Official Full Name PRAME family member 36, pseudogeneprovided by HGNC Primary source HGNC:HGNC:51897 See related AllianceGenome:HGNC:51897 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PRAMEF4, Official Symbol PRAMEF4provided by HGNC Official Full Name PRAME family member 4provided by HGNC Primary source HGNC:HGNC:31971 See related Ensembl:ENSG00000243073 AllianceGenome:HGNC:31971 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF5, Official Symbol PRAMEF5provided by HGNC Official Full Name PRAME family member 5provided by HGNC Primary source HGNC:HGNC:27995 See related Ensembl:ENSG00000270601 AllianceGenome:HGNC:27995 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAMEF23; PRAMEF5L Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF6, Official Symbol PRAMEF6provided by HGNC Official Full Name PRAME family member 6provided by HGNC Primary source HGNC:HGNC:30583 See related Ensembl:ENSG00000232423 AllianceGenome:HGNC:30583 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables ubiquitin ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRAMEF7, Official Symbol PRAMEF7provided by HGNC Official Full Name PRAME family member 7provided by HGNC Primary source HGNC:HGNC:28415 See related Ensembl:ENSG00000204510 AllianceGenome:HGNC:28415 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF8, Official Symbol PRAMEF8provided by HGNC Official Full Name PRAME family member 8provided by HGNC Primary source HGNC:HGNC:24074 See related Ensembl:ENSG00000182330 AllianceGenome:HGNC:24074 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRAMEF24 Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
PRAMEF9, Official Symbol PRAMEF9provided by HGNC Official Full Name PRAME family member 9provided by HGNC Primary source HGNC:HGNC:27996 See related Ensembl:ENSG00000204505 AllianceGenome:HGNC:27996 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
PRANCR, Official Symbol PRANCRprovided by HGNC Official Full Name progenitor renewal associated non-coding RNAprovided by HGNC Primary source HGNC:HGNC:51126 See related Ensembl:ENSG00000257815 MIM:619085; AllianceGenome:HGNC:51126 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNOT2-DT; LINC01481 Expression Ubiquitous expression in bone marrow (RPKM 4.1), testis (RPKM 2.9) and 25 other tissues See more
PRAP1, Official Symbol PRAP1provided by HGNC Official Full Name proline rich acidic protein 1provided by HGNC Primary source HGNC:HGNC:23304 See related Ensembl:ENSG00000165828 MIM:609776; AllianceGenome:HGNC:23304 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UPA; PRO1195 Summary Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues See more Orthologs mouse all
PRB1, Official Symbol PRB1provided by HGNC Official Full Name proline rich protein BstNI subfamily 1provided by HGNC Primary source HGNC:HGNC:9337 See related Ensembl:ENSG00000251655 MIM:180989; AllianceGenome:HGNC:9337 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PM; PMF; PMS; PRB1L; PRB1M Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Restricted expression toward salivary gland (RPKM 6228.4) See more Orthologs all
PRB2, Official Symbol PRB2provided by HGNC Official Full Name proline rich protein BstNI subfamily 2provided by HGNC Primary source HGNC:HGNC:9338 See related Ensembl:ENSG00000121335 MIM:168810; AllianceGenome:HGNC:9338 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Ps; cP7; IB-9; PRPPRB1 Summary This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, May 2023] Expression Restricted expression toward salivary gland (RPKM 6077.8) See more Orthologs all
PRB3, Official Symbol PRB3provided by HGNC Official Full Name proline rich protein BstNI subfamily 3provided by HGNC Primary source HGNC:HGNC:9339 See related Ensembl:ENSG00000197870 MIM:168840; AllianceGenome:HGNC:9339 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G1; PRG Summary This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015] Expression Restricted expression toward salivary gland (RPKM 9550.6) See more Orthologs all
PRB4, Official Symbol PRB4provided by HGNC Official Full Name proline rich protein BstNI subfamily 4provided by HGNC Primary source HGNC:HGNC:9340 See related Ensembl:ENSG00000230657 MIM:180990; AllianceGenome:HGNC:9340 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Po Summary This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Small" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015] Expression Restricted expression toward salivary gland (RPKM 1203.4) See more Orthologs all
PRC1, Official Symbol PRC1provided by HGNC Official Full Name protein regulator of cytokinesis 1provided by HGNC Primary source HGNC:HGNC:9341 See related Ensembl:ENSG00000198901 MIM:603484; AllianceGenome:HGNC:9341 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASE1 Summary This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Expression Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues See more Orthologs mouse all
PRC1-AS1, Official Symbol PRC1-AS1provided by HGNC Official Full Name PRC1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:48587 See related Ensembl:ENSG00000258725 AllianceGenome:HGNC:48587 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 20.5), bone marrow (RPKM 11.1) and 13 other tissues See more
PRCC, Official Symbol PRCCprovided by HGNC Official Full Name proline rich mitotic checkpoint control factorprovided by HGNC Primary source HGNC:HGNC:9343 See related Ensembl:ENSG00000143294 MIM:179755; AllianceGenome:HGNC:9343 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPRC; RCCP1 Summary This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010] Expression Ubiquitous expression in brain (RPKM 14.8), spleen (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
PRCD, Official Symbol PRCDprovided by HGNC Official Full Name photoreceptor disc componentprovided by HGNC Primary source HGNC:HGNC:32528 See related Ensembl:ENSG00000214140 MIM:610598; AllianceGenome:HGNC:32528 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP36 Summary This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in fat (RPKM 1.8), adrenal (RPKM 1.0) and 23 other tissues See more Orthologs mouse all
PRCP, Official Symbol PRCPprovided by HGNC Official Full Name prolylcarboxypeptidaseprovided by HGNC Primary source HGNC:HGNC:9344 See related Ensembl:ENSG00000137509 MIM:176785; AllianceGenome:HGNC:9344 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCP; HUMPCP Summary This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in placenta (RPKM 42.6), urinary bladder (RPKM 37.6) and 25 other tissues See more Orthologs mouse all
PRCPP1, Official Symbol PRCPP1provided by HGNC Official Full Name PRCP pseudogene 1provided by HGNC Primary source HGNC:HGNC:54653 See related Ensembl:ENSG00000232556 AllianceGenome:HGNC:54653 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRDM1, Official Symbol PRDM1provided by HGNC Official Full Name PR/SET domain 1provided by HGNC Primary source HGNC:HGNC:9346 See related Ensembl:ENSG00000057657 MIM:603423; AllianceGenome:HGNC:9346 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLIMP1; PRDI-BF1 Summary This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 16.3), endometrium (RPKM 7.2) and 17 other tissues See more Orthologs mouse all
PRDM10, Official Symbol PRDM10provided by HGNC Official Full Name PR/SET domain 10provided by HGNC Primary source HGNC:HGNC:13995 See related Ensembl:ENSG00000170325 MIM:618319; AllianceGenome:HGNC:13995 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BHD2; PFM7; TRIS Summary The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 1.6), lymph node (RPKM 1.5) and 25 other tissues See more Orthologs mouse all
PRDM11, Official Symbol PRDM11provided by HGNC Official Full Name PR/SET domain 11provided by HGNC Primary source HGNC:HGNC:13996 See related Ensembl:ENSG00000019485 MIM:616347; AllianceGenome:HGNC:13996 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFM8 Summary Predicted to enable chromatin binding activity. Involved in several processes, including negative regulation of cell growth; positive regulation of fibroblast apoptotic process; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 2.3), ovary (RPKM 1.9) and 24 other tissues See more Orthologs mouse all
PRDM12, Official Symbol PRDM12provided by HGNC Official Full Name PR/SET domain 12provided by HGNC Primary source HGNC:HGNC:13997 See related Ensembl:ENSG00000130711 MIM:616458; AllianceGenome:HGNC:13997 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFM9; HSAN8 Summary This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017] Expression Low expression observed in reference dataset See more Orthologs mouse all
PRDM13, Official Symbol PRDM13provided by HGNC Official Full Name PR/SET domain 13provided by HGNC Primary source HGNC:HGNC:13998 See related Ensembl:ENSG00000112238 MIM:616741; AllianceGenome:HGNC:13998 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCH17; PFM10; CDIDHH; MU-MB-20.220 Summary Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and histone methyltransferase activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and neurogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
PRDM14, Official Symbol PRDM14provided by HGNC Official Full Name PR/SET domain 14provided by HGNC Primary source HGNC:HGNC:14001 See related Ensembl:ENSG00000147596 MIM:611781; AllianceGenome:HGNC:14001 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFM11 Summary This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
PRDM15, Official Symbol PRDM15provided by HGNC Official Full Name PR/SET domain 15provided by HGNC Primary source HGNC:HGNC:13999 See related Ensembl:ENSG00000141956 MIM:617692; AllianceGenome:HGNC:13999 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFM15; ZNF298; C21orf83 Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 2.4), appendix (RPKM 1.2) and 25 other tissues See more Orthologs mouse all
PRDM16, Official Symbol PRDM16provided by HGNC Official Full Name PR/SET domain 16provided by HGNC Primary source HGNC:HGNC:14000 See related Ensembl:ENSG00000142611 MIM:605557; AllianceGenome:HGNC:14000 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEL1; KMT8F; LVNC8; PFM13; CMD1LL Summary The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in stomach (RPKM 3.4), thyroid (RPKM 3.1) and 17 other tissues See more Orthologs mouse all
PRDM16-DT, Official Symbol PRDM16-DTprovided by HGNC Official Full Name PRDM16 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:48664 See related Ensembl:ENSG00000177133 AllianceGenome:HGNC:48664 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00982; lnc-dPrdm16 Expression Biased expression in kidney (RPKM 17.6), stomach (RPKM 7.0) and 5 other tissues See more
PRDM2, Official Symbol PRDM2provided by HGNC Official Full Name PR/SET domain 2provided by HGNC Primary source HGNC:HGNC:9347 See related Ensembl:ENSG00000116731 MIM:601196; AllianceGenome:HGNC:9347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIZ; KMT8; RIZ1; RIZ2; KMT8A; MTB-ZF; HUMHOXY1 Summary This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in bone marrow (RPKM 10.7), ovary (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
PRDM4, Official Symbol PRDM4provided by HGNC Official Full Name PR/SET domain 4provided by HGNC Primary source HGNC:HGNC:9348 See related Ensembl:ENSG00000110851 MIM:605780; AllianceGenome:HGNC:9348 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFM1 Summary The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 10.4), esophagus (RPKM 8.7) and 25 other tissues See more Orthologs mouse all
PRDM5, Official Symbol PRDM5provided by HGNC Official Full Name PR/SET domain 5provided by HGNC Primary source HGNC:HGNC:9349 See related Ensembl:ENSG00000138738 MIM:614161; AllianceGenome:HGNC:9349 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCS2; PFM2 Summary The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 2.4), endometrium (RPKM 1.5) and 24 other tissues See more Orthologs mouse all
PRDM6, Official Symbol PRDM6provided by HGNC Official Full Name PR/SET domain 6provided by HGNC Primary source HGNC:HGNC:9350 See related Ensembl:ENSG00000061455 MIM:616982; AllianceGenome:HGNC:9350 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDA3; KMT8C; PRISM Summary The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017] Expression Broad expression in gall bladder (RPKM 2.3), placenta (RPKM 2.0) and 16 other tissues See more Orthologs mouse all
PRDM7, Official Symbol PRDM7provided by HGNC Official Full Name PR/SET domain 7provided by HGNC Primary source HGNC:HGNC:9351 See related Ensembl:ENSG00000126856 MIM:609759; AllianceGenome:HGNC:9351 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFM4; ZNF910 Summary This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013] Expression Low expression observed in reference dataset See more Orthologs all