psui3905/ncbi_genes_summary huggingface dataset:
NUBPL, Official Symbol NUBPLprovided by HGNC Official Full Name NUBP iron-sulfur cluster assembly factor, mitochondrialprovided by HGNC Primary source HGNC:HGNC:20278 See related Ensembl:ENSG00000151413 MIM:613621; AllianceGenome:HGNC:20278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IND1; huInd1; MC1DN21; C14orf127 Summary This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Mutations in this gene cause mitochondrial complex I deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in fat (RPKM 1.5), heart (RPKM 1.4) and 25 other tissues See more Orthologs mouse all
NUCB1, Official Symbol NUCB1provided by HGNC Official Full Name nucleobindin 1provided by HGNC Primary source HGNC:HGNC:8043 See related Ensembl:ENSG00000104805 MIM:601323; AllianceGenome:HGNC:8043 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUC; CALNUC Summary This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010] Expression Ubiquitous expression in kidney (RPKM 89.1), fat (RPKM 86.3) and 25 other tissues See more Orthologs mouse all
NUCB1-AS1, Official Symbol NUCB1-AS1provided by HGNC Official Full Name NUCB1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40419 See related Ensembl:ENSG00000235191 AllianceGenome:HGNC:40419 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in kidney (RPKM 35.3), fat (RPKM 31.2) and 25 other tissues See more
NUCB2, Official Symbol NUCB2provided by HGNC Official Full Name nucleobindin 2provided by HGNC Primary source HGNC:HGNC:8044 See related Ensembl:ENSG00000070081 MIM:608020; AllianceGenome:HGNC:8044 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEFA; HEL-S-109 Summary This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011] Expression Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues See more Orthologs mouse all
NUCKS1, Official Symbol NUCKS1provided by HGNC Official Full Name nuclear casein kinase and cyclin dependent kinase substrate 1provided by HGNC Primary source HGNC:HGNC:29923 See related Ensembl:ENSG00000069275 MIM:611912; AllianceGenome:HGNC:29923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JC7; NUCKS Summary This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in brain (RPKM 77.7), thyroid (RPKM 69.9) and 25 other tissues See more Orthologs mouse all
NUCKS1P1, Official Symbol NUCKS1P1provided by HGNC Official Full Name nuclear casein kinase and cyclin dependent kinase substrate 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:51943 See related Ensembl:ENSG00000232864 AllianceGenome:HGNC:51943 Gene type pseudo RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUDC, Official Symbol NUDCprovided by HGNC Official Full Name nuclear distribution C, dynein complex regulatorprovided by HGNC Primary source HGNC:HGNC:8045 See related Ensembl:ENSG00000090273 MIM:610325; AllianceGenome:HGNC:8045 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNUDC; MNUDC; NPD011 Summary This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in testis (RPKM 27.7), adrenal (RPKM 27.5) and 25 other tissues See more Orthologs mouse all
NUDCD1, Official Symbol NUDCD1provided by HGNC Official Full Name NudC domain containing 1provided by HGNC Primary source HGNC:HGNC:24306 See related Ensembl:ENSG00000120526 MIM:606109; AllianceGenome:HGNC:24306 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CML66; OVA66 Summary Predicted to be involved in immune system process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.8), placenta (RPKM 5.8) and 25 other tissues See more Orthologs mouse all
NUDCD2, Official Symbol NUDCD2provided by HGNC Official Full Name NudC domain containing 2provided by HGNC Primary source HGNC:HGNC:30535 See related Ensembl:ENSG00000170584 MIM:620136; AllianceGenome:HGNC:30535 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NudCL2 Summary Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 16.1), prostate (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
NUDCD3, Official Symbol NUDCD3provided by HGNC Official Full Name NudC domain containing 3provided by HGNC Primary source HGNC:HGNC:22208 See related Ensembl:ENSG00000015676 MIM:610296; AllianceGenome:HGNC:22208 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NudCL Summary The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 28.0), ovary (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
NUDT1, Official Symbol NUDT1provided by HGNC Official Full Name nudix hydrolase 1provided by HGNC Primary source HGNC:HGNC:8048 See related Ensembl:ENSG00000106268 MIM:600312; AllianceGenome:HGNC:8048 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTH1 Summary Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018] Expression Broad expression in bone marrow (RPKM 17.0), testis (RPKM 13.9) and 24 other tissues See more Orthologs mouse all
NUDT10, Official Symbol NUDT10provided by HGNC Official Full Name nudix hydrolase 10provided by HGNC Primary source HGNC:HGNC:17621 See related Ensembl:ENSG00000122824 MIM:300527; AllianceGenome:HGNC:17621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APS2; DIPP3a; DIPP3-alpha Summary This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015] Expression Biased expression in testis (RPKM 20.6), brain (RPKM 8.6) and 6 other tissues See more Orthologs all
NUDT11, Official Symbol NUDT11provided by HGNC Official Full Name nudix hydrolase 11provided by HGNC Primary source HGNC:HGNC:18011 See related Ensembl:ENSG00000196368 MIM:300528; AllianceGenome:HGNC:18011 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APS1; ASP1; DIPP3b; DIPP3beta; hDIPP3beta Summary NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008] Expression Biased expression in testis (RPKM 29.1), brain (RPKM 16.8) and 4 other tissues See more Orthologs mouse all
NUDT12, Official Symbol NUDT12provided by HGNC Official Full Name nudix hydrolase 12provided by HGNC Primary source HGNC:HGNC:18826 See related Ensembl:ENSG00000112874 MIM:609232; AllianceGenome:HGNC:18826 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in kidney (RPKM 12.0), thyroid (RPKM 10.7) and 24 other tissues See more Orthologs mouse all
NUDT13, Official Symbol NUDT13provided by HGNC Official Full Name nudix hydrolase 13provided by HGNC Primary source HGNC:HGNC:18827 See related Ensembl:ENSG00000166321 MIM:609233; AllianceGenome:HGNC:18827 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NADH metabolic process and NADP catabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.0), skin (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
NUDT14, Official Symbol NUDT14provided by HGNC Official Full Name nudix hydrolase 14provided by HGNC Primary source HGNC:HGNC:20141 See related Ensembl:ENSG00000183828 MIM:609219; AllianceGenome:HGNC:20141 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UGPP; UGPPase Summary The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in fat (RPKM 8.0), kidney (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
NUDT15, Official Symbol NUDT15provided by HGNC Official Full Name nudix hydrolase 15provided by HGNC Primary source HGNC:HGNC:23063 See related Ensembl:ENSG00000136159 MIM:615792; AllianceGenome:HGNC:23063 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTH2; NUDT15D Summary This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in colon (RPKM 4.7), duodenum (RPKM 4.1) and 25 other tissues See more Orthologs mouse all
NUDT16, Official Symbol NUDT16provided by HGNC Official Full Name nudix hydrolase 16provided by HGNC Primary source HGNC:HGNC:26442 See related Ensembl:ENSG00000198585 MIM:617381; AllianceGenome:HGNC:26442 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables several functions, including RNA binding activity; metal ion binding activity; and purine ribonucleoside triphosphate binding activity. Involved in IDP catabolic process; RNA metabolic process; and positive regulation of cell cycle process. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 14.5), kidney (RPKM 13.4) and 25 other tissues See more Orthologs mouse all
NUDT16L1, Official Symbol NUDT16L1provided by HGNC Official Full Name nudix hydrolase 16 like 1provided by HGNC Primary source HGNC:HGNC:28154 See related Ensembl:ENSG00000168101 MIM:617338; AllianceGenome:HGNC:28154 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDOS; TIRR Summary Enables snoRNA binding activity. Involved in negative regulation of double-strand break repair via nonhomologous end joining. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 5.2), prostate (RPKM 4.4) and 25 other tissues See more Orthologs mouse all
NUDT16L2P, Official Symbol NUDT16L2Pprovided by HGNC Official Full Name nudix hydrolase 16 like 2, pseudogeneprovided by HGNC Primary source HGNC:HGNC:27189 See related Ensembl:ENSG00000246082 AllianceGenome:HGNC:27189 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUDT16P; NUDT16P1 Expression Broad expression in thyroid (RPKM 6.6), small intestine (RPKM 4.3) and 23 other tissues See more
NUDT17, Official Symbol NUDT17provided by HGNC Official Full Name nudix hydrolase 17provided by HGNC Primary source HGNC:HGNC:26618 See related Ensembl:ENSG00000186364 AllianceGenome:HGNC:26618 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NAD catabolic process; NADH metabolic process; and NADP catabolic process. Predicted to be active in cytosol and peroxisome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 3.7), endometrium (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
NUDT18, Official Symbol NUDT18provided by HGNC Official Full Name nudix hydrolase 18provided by HGNC Primary source HGNC:HGNC:26194 See related Ensembl:ENSG00000275074 MIM:615791; AllianceGenome:HGNC:26194 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTH3 Summary The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012] Expression Ubiquitous expression in spleen (RPKM 3.1), lymph node (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
NUDT19, Official Symbol NUDT19provided by HGNC Official Full Name nudix hydrolase 19provided by HGNC Primary source HGNC:HGNC:32036 See related Ensembl:ENSG00000213965 AllianceGenome:HGNC:32036 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP2 Summary Predicted to enable magnesium ion binding activity. Predicted to be involved in purine nucleoside bisphosphate metabolic process. Predicted to be located in cytosol and peroxisomal matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 3.2), prostate (RPKM 2.7) and 25 other tissues See more Orthologs mouse all
NUDT19-DT, Official Symbol NUDT19-DTprovided by HGNC Official Full Name NUDT19 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55296 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
NUDT19P4, Official Symbol NUDT19P4provided by HGNC Official Full Name NUDT19 pseudogene 4provided by HGNC Primary source HGNC:HGNC:43588 See related Ensembl:ENSG00000270900 AllianceGenome:HGNC:43588 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUDT19P5, Official Symbol NUDT19P5provided by HGNC Official Full Name NUDT19 pseudogene 5provided by HGNC Primary source HGNC:HGNC:43589 See related Ensembl:ENSG00000251073 AllianceGenome:HGNC:43589 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUDT19P6, Official Symbol NUDT19P6provided by HGNC Official Full Name NUDT19 pseudogene 6provided by HGNC Primary source HGNC:HGNC:55061 See related Ensembl:ENSG00000270625 AllianceGenome:HGNC:55061 Gene type pseudo RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUDT2, Official Symbol NUDT2provided by HGNC Official Full Name nudix hydrolase 2provided by HGNC Primary source HGNC:HGNC:8049 See related Ensembl:ENSG00000164978 MIM:602852; AllianceGenome:HGNC:8049 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APAH1; IDDPN Summary This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in ovary (RPKM 11.6), prostate (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
NUDT21, Official Symbol NUDT21provided by HGNC Official Full Name nudix hydrolase 21provided by HGNC Primary source HGNC:HGNC:13870 See related Ensembl:ENSG00000167005 MIM:604978; AllianceGenome:HGNC:13870 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPSF5; CFIM25 Summary The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 30.7), ovary (RPKM 29.1) and 25 other tissues See more Orthologs mouse all
NUDT22, Official Symbol NUDT22provided by HGNC Official Full Name nudix hydrolase 22provided by HGNC Primary source HGNC:HGNC:28189 See related Ensembl:ENSG00000149761 AllianceGenome:HGNC:28189 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables UDP-sugar diphosphatase activity and metal ion binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 16.3), spleen (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
NUDT3, Official Symbol NUDT3provided by HGNC Official Full Name nudix hydrolase 3provided by HGNC Primary source HGNC:HGNC:8050 See related Ensembl:ENSG00000272325 MIM:609228; AllianceGenome:HGNC:8050 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIPP; DIPP1; DIPP-1 Summary NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011] Expression Ubiquitous expression in brain (RPKM 33.6), thyroid (RPKM 19.6) and 25 other tissues See more Orthologs mouse all
NUDT4, Official Symbol NUDT4provided by HGNC Official Full Name nudix hydrolase 4provided by HGNC Primary source HGNC:HGNC:8051 See related Ensembl:ENSG00000173598 MIM:609229; AllianceGenome:HGNC:8051 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIPP2; NUDT4B; DIPP-2B; HDCMB47P; DIPP2beta; DIPP2alpha Summary The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 30.0), kidney (RPKM 25.7) and 25 other tissues See more Orthologs mouse all
NUDT4B, Official Symbol NUDT4Bprovided by HGNC Official Full Name nudix hydrolase 4Bprovided by HGNC Primary source HGNC:HGNC:18012 See related Ensembl:ENSG00000177144 AllianceGenome:HGNC:18012 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIPP-2B; NUDT4P1 Summary Predicted to enable pyrophosphatase activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
NUDT4P2, Official Symbol NUDT4P2provided by HGNC Official Full Name nudix hydrolase 4 pseudogene 2provided by HGNC Primary source HGNC:HGNC:18013 See related AllianceGenome:HGNC:18013 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUDT5, Official Symbol NUDT5provided by HGNC Official Full Name nudix hydrolase 5provided by HGNC Primary source HGNC:HGNC:8052 See related Ensembl:ENSG00000165609 MIM:609230; AllianceGenome:HGNC:8052 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as YSA1; YSA1H; YSAH1; hNUDT5 Summary This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in liver (RPKM 12.0), skin (RPKM 11.4) and 25 other tissues See more Orthologs mouse all
NUDT6, Official Symbol NUDT6provided by HGNC Official Full Name nudix hydrolase 6provided by HGNC Primary source HGNC:HGNC:8053 See related Ensembl:ENSG00000170917 MIM:606261; AllianceGenome:HGNC:8053 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS Summary This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in fat (RPKM 12.5), kidney (RPKM 8.8) and 23 other tissues See more Orthologs mouse all
NUDT7, Official Symbol NUDT7provided by HGNC Official Full Name nudix hydrolase 7provided by HGNC Primary source HGNC:HGNC:8054 See related Ensembl:ENSG00000140876 MIM:609231; AllianceGenome:HGNC:8054 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in liver (RPKM 10.5), heart (RPKM 9.9) and 24 other tissues See more Orthologs mouse all
NUDT8, Official Symbol NUDT8provided by HGNC Official Full Name nudix hydrolase 8provided by HGNC Primary source HGNC:HGNC:8055 See related Ensembl:ENSG00000167799 AllianceGenome:HGNC:8055 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable magnesium ion binding activity and manganese ion binding activity. Predicted to be involved in purine nucleoside bisphosphate catabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 5.4), heart (RPKM 4.8) and 25 other tissues See more Orthologs mouse all
NUDT9, Official Symbol NUDT9provided by HGNC Official Full Name nudix hydrolase 9provided by HGNC Primary source HGNC:HGNC:8056 See related Ensembl:ENSG00000170502 MIM:606022; AllianceGenome:HGNC:8056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUDT10 Summary The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in kidney (RPKM 6.8), prostate (RPKM 6.3) and 25 other tissues See more Orthologs mouse all
NUF2, Official Symbol NUF2provided by HGNC Official Full Name NUF2 component of NDC80 kinetochore complexprovided by HGNC Primary source HGNC:HGNC:14621 See related Ensembl:ENSG00000143228 MIM:611772; AllianceGenome:HGNC:14621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDCA1; CT106; NUF2R Summary This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 23.0), bone marrow (RPKM 9.4) and 11 other tissues See more Orthologs mouse all
NUFIP1, Official Symbol NUFIP1provided by HGNC Official Full Name nuclear FMR1 interacting protein 1provided by HGNC Primary source HGNC:HGNC:8057 See related Ensembl:ENSG00000083635 MIM:604354; AllianceGenome:HGNC:8057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Rsa1; NUFIP; bA540M5.1 Summary This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in testis (RPKM 3.6), brain (RPKM 2.9) and 25 other tissues See more Orthologs mouse all
NUFIP2, Official Symbol NUFIP2provided by HGNC Official Full Name nuclear FMR1 interacting protein 2provided by HGNC Primary source HGNC:HGNC:17634 See related Ensembl:ENSG00000108256 MIM:609356; AllianceGenome:HGNC:17634 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIG1; NUFP2; 82-FIP; FIP-82; 182-FIP Summary Enables RNA binding activity. Located in cytoplasmic stress granule; cytosol; and nuclear body. Part of polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 15.1), placenta (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
NUGGC, Official Symbol NUGGCprovided by HGNC Official Full Name nuclear GTPase, germinal center associatedprovided by HGNC Primary source HGNC:HGNC:33550 See related Ensembl:ENSG00000189233 MIM:619088; AllianceGenome:HGNC:33550 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLIPGC; C8orf80; SLIP-GC; HMFN0672 Summary Enables GTPase activity. Involved in cellular response to lipopolysaccharide; negative regulation of apoptotic process; and regulation of nuclear cell cycle DNA replication. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 5.9), liver (RPKM 3.6) and 9 other tissues See more Orthologs mouse all
NUMA1, Official Symbol NUMA1provided by HGNC Official Full Name nuclear mitotic apparatus protein 1provided by HGNC Primary source HGNC:HGNC:8059 See related Ensembl:ENSG00000137497 MIM:164009; AllianceGenome:HGNC:8059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUMA; NMP-22 Summary This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] Expression Ubiquitous expression in prostate (RPKM 51.4), ovary (RPKM 49.9) and 25 other tissues See more Orthologs mouse all
NUMB, Official Symbol NUMBprovided by HGNC Official Full Name NUMB endocytic adaptor proteinprovided by HGNC Primary source HGNC:HGNC:8060 See related Ensembl:ENSG00000133961 MIM:603728; AllianceGenome:HGNC:8060 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S171; C14orf41; c14_5527 Summary The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in lung (RPKM 25.7), gall bladder (RPKM 21.4) and 25 other tissues See more Orthologs mouse all
NUMBL, Official Symbol NUMBLprovided by HGNC Official Full Name NUMB like endocytic adaptor proteinprovided by HGNC Primary source HGNC:HGNC:8061 See related Ensembl:ENSG00000105245 MIM:604018; AllianceGenome:HGNC:8061 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE Summary Involved in cytokine-mediated signaling pathway and protein metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 8.6), endometrium (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
NUP107, Official Symbol NUP107provided by HGNC Official Full Name nucleoporin 107provided by HGNC Primary source HGNC:HGNC:29914 See related Ensembl:ENSG00000111581 MIM:607617; AllianceGenome:HGNC:29914 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ODG6; NUP84; NPHS11; ODG6; GAMOS7 Summary This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 14.7), lymph node (RPKM 14.2) and 25 other tissues See more Orthologs mouse all
NUP133, Official Symbol NUP133provided by HGNC Official Full Name nucleoporin 133provided by HGNC Primary source HGNC:HGNC:18016 See related Ensembl:ENSG00000069248 MIM:607613; AllianceGenome:HGNC:18016 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAMOS8; NPHS18; hNUP133 Summary The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 11.8), brain (RPKM 11.8) and 25 other tissues See more Orthologs mouse all
NUP153, Official Symbol NUP153provided by HGNC Official Full Name nucleoporin 153provided by HGNC Primary source HGNC:HGNC:8062 See related Ensembl:ENSG00000124789 MIM:603948; AllianceGenome:HGNC:8062 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N153; HNUP153 Summary Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] Expression Ubiquitous expression in testis (RPKM 19.5), bone marrow (RPKM 18.1) and 25 other tissues See more Orthologs mouse all
NUP153-AS1, Official Symbol NUP153-AS1provided by HGNC Official Full Name NUP153 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55217 See related Ensembl:ENSG00000272269 AllianceGenome:HGNC:55217 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 5.6) and lymph node (RPKM 0.4) See more
NUP155, Official Symbol NUP155provided by HGNC Official Full Name nucleoporin 155provided by HGNC Primary source HGNC:HGNC:8063 See related Ensembl:ENSG00000113569 MIM:606694; AllianceGenome:HGNC:8063 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as N155; ATFB15 Summary Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013] Expression Broad expression in testis (RPKM 44.4), bone marrow (RPKM 5.5) and 19 other tissues See more Orthologs mouse all
NUP160, Official Symbol NUP160provided by HGNC Official Full Name nucleoporin 160provided by HGNC Primary source HGNC:HGNC:18017 See related Ensembl:ENSG00000030066 MIM:607614; AllianceGenome:HGNC:18017 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPHS19 Summary A structural constituent of nuclear pore. Involved in mRNA export from nucleus and nephron development. Part of nuclear pore outer ring. Colocalizes with kinetochore. Implicated in nephrotic syndrome type 19. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 10.0), appendix (RPKM 9.5) and 25 other tissues See more Orthologs mouse all