psui3905/ncbi_genes_summary huggingface dataset:
UBE3B, Official Symbol UBE3Bprovided by HGNC Official Full Name ubiquitin protein ligase E3Bprovided by HGNC Primary source HGNC:HGNC:13478 See related Ensembl:ENSG00000151148 MIM:608047; AllianceGenome:HGNC:13478 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KOS; BPIDS Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 7.7), testis (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
UBE3C, Official Symbol UBE3Cprovided by HGNC Official Full Name ubiquitin protein ligase E3Cprovided by HGNC Primary source HGNC:HGNC:16803 See related Ensembl:ENSG00000009335 MIM:614454; AllianceGenome:HGNC:16803 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAUL; HECTH2; NDSMBA; NEDSMBA Summary Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination. Predicted to be located in nucleus. Predicted to be part of proteasome complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 21.1), esophagus (RPKM 16.8) and 25 other tissues See more Orthologs mouse all
UBE3D, Official Symbol UBE3Dprovided by HGNC Official Full Name ubiquitin protein ligase E3Dprovided by HGNC Primary source HGNC:HGNC:21381 See related Ensembl:ENSG00000118420 MIM:612495; AllianceGenome:HGNC:21381 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H10BH; UBE2CBP; YJR141W; C6orf157 Summary Enables cyclin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
UBE4A, Official Symbol UBE4Aprovided by HGNC Official Full Name ubiquitination factor E4Aprovided by HGNC Primary source HGNC:HGNC:12499 See related Ensembl:ENSG00000110344 MIM:603753; AllianceGenome:HGNC:12499 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E4; UFD2; UBOX2; NEDHMS Summary This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in brain (RPKM 15.5), appendix (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
UBE4B, Official Symbol UBE4Bprovided by HGNC Official Full Name ubiquitination factor E4Bprovided by HGNC Primary source HGNC:HGNC:12500 See related Ensembl:ENSG00000130939 MIM:613565; AllianceGenome:HGNC:12500 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E4; UFD2; HDNB1; UBOX3; UFD2A Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 12.1), skin (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
UBFD1, Official Symbol UBFD1provided by HGNC Official Full Name ubiquitin family domain containing 1provided by HGNC Primary source HGNC:HGNC:30565 See related Ensembl:ENSG00000103353 AllianceGenome:HGNC:30565 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBPH Summary Enables RNA binding activity and cadherin binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 14.6), thyroid (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
UBFD1P1, Official Symbol UBFD1P1provided by HGNC Official Full Name ubiquitin family domain containing 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:42389 See related AllianceGenome:HGNC:42389 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBIAD1, Official Symbol UBIAD1provided by HGNC Official Full Name UbiA prenyltransferase domain containing 1provided by HGNC Primary source HGNC:HGNC:30791 See related Ensembl:ENSG00000120942 MIM:611632; AllianceGenome:HGNC:30791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCCD; TERE1 Summary This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in testis (RPKM 2.8), ovary (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
UBL3, Official Symbol UBL3provided by HGNC Official Full Name ubiquitin like 3provided by HGNC Primary source HGNC:HGNC:12504 See related Ensembl:ENSG00000122042 MIM:604711; AllianceGenome:HGNC:12504 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCG-1; PNSC1 Summary Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 38.2), stomach (RPKM 32.6) and 25 other tissues See more Orthologs mouse all
UBL4A, Official Symbol UBL4Aprovided by HGNC Official Full Name ubiquitin like 4Aprovided by HGNC Primary source HGNC:HGNC:12505 See related Ensembl:ENSG00000102178 MIM:312070; AllianceGenome:HGNC:12505 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDX; G6PD; GET5; MDY2; UBL4; TMA24; DX254E; DXS254E Summary Enables chaperone binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in cytosol; membrane; and nucleoplasm. Part of BAT3 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 16.9), brain (RPKM 12.9) and 25 other tissues See more Orthologs mouse all
UBL4B, Official Symbol UBL4Bprovided by HGNC Official Full Name ubiquitin like 4Bprovided by HGNC Primary source HGNC:HGNC:32309 See related Ensembl:ENSG00000186150 MIM:611127; AllianceGenome:HGNC:32309 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
UBL5, Official Symbol UBL5provided by HGNC Official Full Name ubiquitin like 5provided by HGNC Primary source HGNC:HGNC:13736 See related Ensembl:ENSG00000198258 MIM:606849; AllianceGenome:HGNC:13736 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HUB1 Summary This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in kidney (RPKM 86.7), adrenal (RPKM 83.4) and 25 other tissues See more Orthologs mouse all
UBL5P1, Official Symbol UBL5P1provided by HGNC Official Full Name ubiquitin like 5 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44639 See related Ensembl:ENSG00000248418 AllianceGenome:HGNC:44639 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBL5P4, Official Symbol UBL5P4provided by HGNC Official Full Name ubiquitin like 5 pseudogene 4provided by HGNC Primary source HGNC:HGNC:44642 See related Ensembl:ENSG00000260224 AllianceGenome:HGNC:44642 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBL7, Official Symbol UBL7provided by HGNC Official Full Name ubiquitin like 7provided by HGNC Primary source HGNC:HGNC:28221 See related Ensembl:ENSG00000138629 MIM:609748; AllianceGenome:HGNC:28221 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCBA1; BMSC-UbP Summary Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 17.2), brain (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
UBLCP1, Official Symbol UBLCP1provided by HGNC Official Full Name ubiquitin like domain containing CTD phosphatase 1provided by HGNC Primary source HGNC:HGNC:28110 See related Ensembl:ENSG00000164332 MIM:609867; AllianceGenome:HGNC:28110 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPUB1 Summary Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 19.2), brain (RPKM 17.4) and 25 other tissues See more Orthologs mouse all
UBN1, Official Symbol UBN1provided by HGNC Official Full Name ubinuclein 1provided by HGNC Primary source HGNC:HGNC:12506 See related Ensembl:ENSG00000118900 MIM:609771; AllianceGenome:HGNC:12506 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VT; VT4 Summary Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016] Expression Broad expression in testis (RPKM 22.1), bone marrow (RPKM 13.0) and 25 other tissues See more Orthologs mouse all
UBN2, Official Symbol UBN2provided by HGNC Official Full Name ubinuclein 2provided by HGNC Primary source HGNC:HGNC:21931 See related Ensembl:ENSG00000157741 MIM:613841; AllianceGenome:HGNC:21931 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in DNA replication-independent chromatin assembly. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 5.1), skin (RPKM 4.0) and 25 other tissues See more Orthologs mouse all
UBOX5, Official Symbol UBOX5provided by HGNC Official Full Name U-box domain containing 5provided by HGNC Primary source HGNC:HGNC:17777 See related Ensembl:ENSG00000185019 MIM:619675; AllianceGenome:HGNC:17777 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UIP5; RNF37; hUIP5; UBCE7IP5 Summary This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Expression Ubiquitous expression in testis (RPKM 3.8), ovary (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
UBOX5-AS1, Official Symbol UBOX5-AS1provided by HGNC Official Full Name UBOX5 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44111 See related Ensembl:ENSG00000235958 AllianceGenome:HGNC:44111 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 2.7), skin (RPKM 2.2) and 25 other tissues See more
UBP1, Official Symbol UBP1provided by HGNC Official Full Name upstream binding protein 1provided by HGNC Primary source HGNC:HGNC:12507 See related Ensembl:ENSG00000153560 MIM:609784; AllianceGenome:HGNC:12507 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LBP1A; LBP1B; LBP-1B; LBP-1a Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of viral transcription and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 21.9), appendix (RPKM 18.6) and 25 other tissues See more Orthologs mouse all
UBQLN1, Official Symbol UBQLN1provided by HGNC Official Full Name ubiquilin 1provided by HGNC Primary source HGNC:HGNC:12508 See related Ensembl:ENSG00000135018 MIM:605046; AllianceGenome:HGNC:12508 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DA41; DSK2; UBQN; XDRP1; PLIC-1 Summary This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 34.9), bone marrow (RPKM 27.8) and 25 other tissues See more Orthologs mouse all
UBQLN2, Official Symbol UBQLN2provided by HGNC Official Full Name ubiquilin 2provided by HGNC Primary source HGNC:HGNC:12509 See related Ensembl:ENSG00000188021 MIM:300264; AllianceGenome:HGNC:12509 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157 Summary This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009] Orthologs mouse all
UBQLN3, Official Symbol UBQLN3provided by HGNC Official Full Name ubiquilin 3provided by HGNC Primary source HGNC:HGNC:12510 See related Ensembl:ENSG00000175520 MIM:605473; AllianceGenome:HGNC:12510 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TUP-1 Summary This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016] Expression Restricted expression toward testis (RPKM 82.9) See more Orthologs all
UBQLN4, Official Symbol UBQLN4provided by HGNC Official Full Name ubiquilin 4provided by HGNC Primary source HGNC:HGNC:1237 See related Ensembl:ENSG00000160803 MIM:605440; AllianceGenome:HGNC:1237 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1U; A1Up; UBIN; CIP75; C1orf6 Summary Enables K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in cellular response to DNA damage stimulus; negative regulation of double-strand break repair via homologous recombination; and regulation of cellular catabolic process. Located in several cellular components, including autophagosome; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with cytosolic proteasome complex and nuclear proteasome complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 15.5), endometrium (RPKM 13.7) and 25 other tissues See more Orthologs mouse all
UBQLNL, Official Symbol UBQLNLprovided by HGNC Official Full Name ubiquilin likeprovided by HGNC Primary source HGNC:HGNC:28294 See related Ensembl:ENSG00000175518 AllianceGenome:HGNC:28294 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
UBR1, Official Symbol UBR1provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 1provided by HGNC Primary source HGNC:HGNC:16808 See related Ensembl:ENSG00000159459 MIM:605981; AllianceGenome:HGNC:16808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JBS Summary The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 7.4), endometrium (RPKM 6.3) and 25 other tissues See more Orthologs mouse all
UBR2, Official Symbol UBR2provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 2provided by HGNC Primary source HGNC:HGNC:21289 See related Ensembl:ENSG00000024048 MIM:609134; AllianceGenome:HGNC:21289 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3 Summary Enables leucine binding activity. Involved in cellular response to leucine and negative regulation of TOR signaling. Predicted to be located in cytosol. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Predicted to colocalize with chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.8), spleen (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
UBR3, Official Symbol UBR3provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 3provided by HGNC Primary source HGNC:HGNC:30467 See related Ensembl:ENSG00000144357 MIM:613831; AllianceGenome:HGNC:30467 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF650 Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; sensory perception of smell; and suckling behavior. Predicted to act upstream of or within in utero embryonic development and olfactory behavior. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 13.7), thyroid (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
UBR4, Official Symbol UBR4provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 4provided by HGNC Primary source HGNC:HGNC:30313 See related Ensembl:ENSG00000127481 MIM:609890; AllianceGenome:HGNC:30313 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p600; ZUBR1; RBAF600 Summary The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in testis (RPKM 21.2), bone marrow (RPKM 14.0) and 25 other tissues See more Orthologs mouse all
UBR5, Official Symbol UBR5provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 5provided by HGNC Primary source HGNC:HGNC:16806 See related Ensembl:ENSG00000104517 MIM:608413; AllianceGenome:HGNC:16806 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DD5; EDD; HYD; EDD1 Summary This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.7), lymph node (RPKM 11.2) and 25 other tissues See more Orthologs mouse all
UBR7, Official Symbol UBR7provided by HGNC Official Full Name ubiquitin protein ligase E3 component n-recognin 7provided by HGNC Primary source HGNC:HGNC:20344 See related Ensembl:ENSG00000012963 MIM:613816; AllianceGenome:HGNC:20344 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LICAS; C14orf130 Summary This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in brain (RPKM 15.7), testis (RPKM 15.4) and 25 other tissues See more Orthologs mouse all
UBTD1, Official Symbol UBTD1provided by HGNC Official Full Name ubiquitin domain containing 1provided by HGNC Primary source HGNC:HGNC:25683 See related Ensembl:ENSG00000165886 MIM:616388; AllianceGenome:HGNC:25683 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014] Expression Broad expression in testis (RPKM 17.5), lung (RPKM 11.7) and 22 other tissues See more Orthologs mouse all
UBTD2, Official Symbol UBTD2provided by HGNC Official Full Name ubiquitin domain containing 2provided by HGNC Primary source HGNC:HGNC:24463 See related Ensembl:ENSG00000168246 MIM:610174; AllianceGenome:HGNC:24463 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCUBP Summary Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 21.6), endometrium (RPKM 12.8) and 24 other tissues See more Orthologs mouse all
UBTF, Official Symbol UBTFprovided by HGNC Official Full Name upstream binding transcription factorprovided by HGNC Primary source HGNC:HGNC:12511 See related Ensembl:ENSG00000108312 MIM:600673; AllianceGenome:HGNC:12511 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBF; UBF1; UBF2; UBF-1; CONDBA; NOR-90 Summary This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in lymph node (RPKM 22.2), thyroid (RPKM 21.0) and 25 other tissues See more Orthologs mouse all
UBTFL1, Official Symbol UBTFL1provided by HGNC Official Full Name upstream binding transcription factor like 1provided by HGNC Primary source HGNC:HGNC:14533 See related Ensembl:ENSG00000255009 MIM:613696; AllianceGenome:HGNC:14533 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HMGPI; C11orf27 Summary Predicted to enable DNA binding activity. Predicted to act upstream of or within blastocyst growth; embryo implantation; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
UBTFL10, Official Symbol UBTFL10provided by HGNC Official Full Name UBTF like 10 (pseudogene)provided by HGNC Primary source HGNC:HGNC:50287 See related Ensembl:ENSG00000255385 AllianceGenome:HGNC:50287 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBTFL2, Official Symbol UBTFL2provided by HGNC Official Full Name UBTF like 2 (pseudogene)provided by HGNC Primary source HGNC:HGNC:35169 See related Ensembl:ENSG00000234376 AllianceGenome:HGNC:35169 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBTFL5, Official Symbol UBTFL5provided by HGNC Official Full Name UBTF like 5 (pseudogene)provided by HGNC Primary source HGNC:HGNC:35405 See related Ensembl:ENSG00000204705 AllianceGenome:HGNC:35405 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBTFL7, Official Symbol UBTFL7provided by HGNC Official Full Name UBTF like 7 (pseudogene)provided by HGNC Primary source HGNC:HGNC:35404 See related Ensembl:ENSG00000229361 AllianceGenome:HGNC:35404 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBTFL9, Official Symbol UBTFL9provided by HGNC Official Full Name UBTF like 9 (pseudogene)provided by HGNC Primary source HGNC:HGNC:50286 See related Ensembl:ENSG00000254567 AllianceGenome:HGNC:50286 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBXN1, Official Symbol UBXN1provided by HGNC Official Full Name UBX domain protein 1provided by HGNC Primary source HGNC:HGNC:18402 See related Ensembl:ENSG00000162191 MIM:616378; AllianceGenome:HGNC:18402 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 2B28; SAKS1; UBXD10 Summary Enables several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 47.6), fat (RPKM 40.5) and 25 other tissues See more Orthologs mouse all
UBXN10, Official Symbol UBXN10provided by HGNC Official Full Name UBX domain protein 10provided by HGNC Primary source HGNC:HGNC:26354 See related Ensembl:ENSG00000162543 MIM:616783; AllianceGenome:HGNC:26354 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBXD3 Summary Involved in cilium assembly. Located in cilium. Colocalizes with intraciliary transport particle B. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 9.4), lung (RPKM 3.6) and 16 other tissues See more Orthologs mouse all
UBXN11, Official Symbol UBXN11provided by HGNC Official Full Name UBX domain protein 11provided by HGNC Primary source HGNC:HGNC:30600 See related Ensembl:ENSG00000158062 MIM:609151; AllianceGenome:HGNC:30600 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SOC; SOCI; COA-1; UBXD5; PP2243 Summary This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 18.9), spleen (RPKM 17.6) and 25 other tissues See more Orthologs mouse all
UBXN2A, Official Symbol UBXN2Aprovided by HGNC Official Full Name UBX domain protein 2Aprovided by HGNC Primary source HGNC:HGNC:27265 See related Ensembl:ENSG00000173960 AllianceGenome:HGNC:27265 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBXD4 Summary Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; regulation of gene expression; and regulation of protein metabolic process. Predicted to be located in cis-Golgi network and endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 3.2), esophagus (RPKM 2.9) and 25 other tissues See more Orthologs mouse all
UBXN2B, Official Symbol UBXN2Bprovided by HGNC Official Full Name UBX domain protein 2Bprovided by HGNC Primary source HGNC:HGNC:27035 See related Ensembl:ENSG00000215114 MIM:610686; AllianceGenome:HGNC:27035 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p37 Summary Predicted to enable ubiquitin binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and spindle pole centrosome. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 9.6), thyroid (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
UBXN4, Official Symbol UBXN4provided by HGNC Official Full Name UBX domain protein 4provided by HGNC Primary source HGNC:HGNC:14860 See related Ensembl:ENSG00000144224 MIM:611216; AllianceGenome:HGNC:14860 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBXD2; UBXDC1; erasin Summary UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in thyroid (RPKM 49.4), gall bladder (RPKM 38.6) and 25 other tissues See more Orthologs mouse all
UBXN6, Official Symbol UBXN6provided by HGNC Official Full Name UBX domain protein 6provided by HGNC Primary source HGNC:HGNC:14928 See related Ensembl:ENSG00000167671 MIM:611946; AllianceGenome:HGNC:14928 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBXD1; UBXDC2 Summary Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Is extrinsic component of membrane. Part of endosome and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 49.0), kidney (RPKM 36.6) and 25 other tissues See more Orthologs mouse all
UBXN7, Official Symbol UBXN7provided by HGNC Official Full Name UBX domain protein 7provided by HGNC Primary source HGNC:HGNC:29119 See related Ensembl:ENSG00000163960 MIM:616379; AllianceGenome:HGNC:29119 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBXD7 Summary Enables ubiquitin binding activity and ubiquitin protein ligase binding activity. Located in nuclear body. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
UBXN8, Official Symbol UBXN8provided by HGNC Official Full Name UBX domain protein 8provided by HGNC Primary source HGNC:HGNC:30307 See related Ensembl:ENSG00000104691 MIM:602155; AllianceGenome:HGNC:30307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as REP8; UBXD6; D8S2298E Summary p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013] Expression Ubiquitous expression in ovary (RPKM 15.4), testis (RPKM 6.3) and 23 other tissues See more Orthologs mouse all
UCA1, Official Symbol UCA1provided by HGNC Official Full Name urothelial cancer associated 1provided by HGNC Primary source HGNC:HGNC:37126 See related Ensembl:ENSG00000214049 MIM:617500; AllianceGenome:HGNC:37126 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CUDR; UCAT1; LINC00178; NCRNA00178; onco-lncRNA-36 Summary This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017] Expression Biased expression in gall bladder (RPKM 19.1), endometrium (RPKM 12.1) and 5 other tissues See more
UCHL1, Official Symbol UCHL1provided by HGNC Official Full Name ubiquitin C-terminal hydrolase L1provided by HGNC Primary source HGNC:HGNC:12513 See related Ensembl:ENSG00000154277 MIM:191342; AllianceGenome:HGNC:12513 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDGOA; PARK5; PGP95; SPG79; PGP9.5; SPG79A; UCHL-1; Uch-L1; HEL-117; PGP 9.5; HEL-S-53 Summary The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] Expression Biased expression in brain (RPKM 389.7), adrenal (RPKM 70.8) and 2 other tissues See more Orthologs mouse all
UCHL3, Official Symbol UCHL3provided by HGNC Official Full Name ubiquitin C-terminal hydrolase L3provided by HGNC Primary source HGNC:HGNC:12515 See related Ensembl:ENSG00000118939 MIM:603090; AllianceGenome:HGNC:12515 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UCH-L3 Summary The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in thyroid (RPKM 5.1), testis (RPKM 4.9) and 25 other tissues See more Orthologs mouse all
UCHL5, Official Symbol UCHL5provided by HGNC Official Full Name ubiquitin C-terminal hydrolase L5provided by HGNC Primary source HGNC:HGNC:19678 See related Ensembl:ENSG00000116750 MIM:610667; AllianceGenome:HGNC:19678 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UCH37; CGI-70; INO80R; UCH-L5 Summary Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues See more Orthologs mouse all