psui3905/ncbi_genes_summary huggingface dataset:
NPIPB14P, Official Symbol NPIPB14Pprovided by HGNC Official Full Name nuclear pore complex interacting protein family member B14, pseudogeneprovided by HGNC Primary source HGNC:HGNC:41990 See related Ensembl:ENSG00000226232 AllianceGenome:HGNC:41990 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPIPB15, Official Symbol NPIPB15provided by HGNC Official Full Name nuclear pore complex interacting protein family member B15provided by HGNC Primary source HGNC:HGNC:34409 See related Ensembl:ENSG00000196436 AllianceGenome:HGNC:34409 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPIPL2; A-761H5.4 Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 17.7), skin (RPKM 3.0) and 23 other tissues See more
NPIPB2, Official Symbol NPIPB2provided by HGNC Official Full Name nuclear pore complex interacting protein family member B2provided by HGNC Primary source HGNC:HGNC:37451 See related Ensembl:ENSG00000234719 AllianceGenome:HGNC:37451 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
NPIPB3, Official Symbol NPIPB3provided by HGNC Official Full Name nuclear pore complex interacting protein family member B3provided by HGNC Primary source HGNC:HGNC:28989 See related MIM:619984; AllianceGenome:HGNC:28989 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPIP; NPIPB; NPIPB5; NPIPL3; KIAA0220L Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Annotation category: suggests misassembly Expression Ubiquitous expression in skin (RPKM 36.9), bone marrow (RPKM 26.9) and 24 other tissues See more Orthologs all
NPIPB4, Official Symbol NPIPB4provided by HGNC Official Full Name nuclear pore complex interacting protein family member B4provided by HGNC Primary source HGNC:HGNC:41985 See related Ensembl:ENSG00000185864 AllianceGenome:HGNC:41985 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 61E3.4 Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 29.6), bone marrow (RPKM 21.2) and 24 other tissues See more Orthologs all
NPIPB5, Official Symbol NPIPB5provided by HGNC Official Full Name nuclear pore complex interacting protein family member B5provided by HGNC Primary source HGNC:HGNC:37233 See related Ensembl:ENSG00000243716 AllianceGenome:HGNC:37233 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 35.9), bone marrow (RPKM 26.2) and 24 other tissues See more
NPIPB6, Official Symbol NPIPB6provided by HGNC Official Full Name nuclear pore complex interacting protein family member B6provided by HGNC Primary source HGNC:HGNC:37454 See related Ensembl:ENSG00000198156 AllianceGenome:HGNC:37454 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPIPB Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 11.9), skin (RPKM 4.0) and 22 other tissues See more Orthologs all
NPIPB7, Official Symbol NPIPB7provided by HGNC Official Full Name nuclear pore complex interacting protein family member B7provided by HGNC Primary source HGNC:HGNC:33832 See related Ensembl:ENSG00000233232 AllianceGenome:HGNC:33832 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPIPL1; A-575C2.4; A-761H5.5 Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
NPIPB8, Official Symbol NPIPB8provided by HGNC Official Full Name nuclear pore complex interacting protein family member B8provided by HGNC Primary source HGNC:HGNC:37490 See related Ensembl:ENSG00000255524 AllianceGenome:HGNC:37490 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 22.6), skin (RPKM 8.3) and 23 other tissues See more
NPIPB9, Official Symbol NPIPB9provided by HGNC Official Full Name nuclear pore complex interacting protein family member B9provided by HGNC Primary source HGNC:HGNC:41987 See related Ensembl:ENSG00000196993 AllianceGenome:HGNC:41987 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 11.3), skin (RPKM 4.2) and 25 other tissues See more
NPIPP1, Official Symbol NPIPP1provided by HGNC Official Full Name nuclear pore complex interacting protein pseudogene 1provided by HGNC Primary source HGNC:HGNC:35407 See related Ensembl:ENSG00000188599 AllianceGenome:HGNC:35407 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPL, Official Symbol NPLprovided by HGNC Official Full Name N-acetylneuraminate pyruvate lyaseprovided by HGNC Primary source HGNC:HGNC:16781 See related Ensembl:ENSG00000135838 MIM:611412; AllianceGenome:HGNC:16781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAL; C112; NPL1; C1orf13 Summary This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Broad expression in placenta (RPKM 18.1), kidney (RPKM 16.5) and 20 other tissues See more Orthologs mouse all
NPLOC4, Official Symbol NPLOC4provided by HGNC Official Full Name NPL4 homolog, ubiquitin recognition factorprovided by HGNC Primary source HGNC:HGNC:18261 See related Ensembl:ENSG00000182446 MIM:606590; AllianceGenome:HGNC:18261 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPL4 Summary Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 14.2), esophagus (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
NPM1, Official Symbol NPM1provided by HGNC Official Full Name nucleophosmin 1provided by HGNC Primary source HGNC:HGNC:7910 See related Ensembl:ENSG00000181163 MIM:164040; AllianceGenome:HGNC:7910 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B23; NPM Summary The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in ovary (RPKM 256.2), lymph node (RPKM 146.3) and 25 other tissues See more Orthologs mouse all
NPM1P10, Official Symbol NPM1P10provided by HGNC Official Full Name nucleophosmin 1 pseudogene 10provided by HGNC Primary source HGNC:HGNC:7912 See related AllianceGenome:HGNC:7912 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P17, Official Symbol NPM1P17provided by HGNC Official Full Name nucleophosmin 1 pseudogene 17provided by HGNC Primary source HGNC:HGNC:7919 See related Ensembl:ENSG00000242070 AllianceGenome:HGNC:7919 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P18, Official Symbol NPM1P18provided by HGNC Official Full Name nucleophosmin 1 pseudogene 18provided by HGNC Primary source HGNC:HGNC:7920 See related AllianceGenome:HGNC:7920 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P2, Official Symbol NPM1P2provided by HGNC Official Full Name nucleophosmin 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:7922 See related AllianceGenome:HGNC:7922 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NG2-6; NPMP2
NPM1P20, Official Symbol NPM1P20provided by HGNC Official Full Name nucleophosmin 1 pseudogene 20provided by HGNC Primary source HGNC:HGNC:20140 See related AllianceGenome:HGNC:20140 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P23, Official Symbol NPM1P23provided by HGNC Official Full Name nucleophosmin 1 pseudogene 23provided by HGNC Primary source HGNC:HGNC:44513 See related Ensembl:ENSG00000242109 AllianceGenome:HGNC:44513 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P25, Official Symbol NPM1P25provided by HGNC Official Full Name nucleophosmin 1 pseudogene 25provided by HGNC Primary source HGNC:HGNC:45204 See related Ensembl:ENSG00000229417 AllianceGenome:HGNC:45204 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P30, Official Symbol NPM1P30provided by HGNC Official Full Name nucleophosmin 1 pseudogene 30provided by HGNC Primary source HGNC:HGNC:45209 See related Ensembl:ENSG00000228219 AllianceGenome:HGNC:45209 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P35, Official Symbol NPM1P35provided by HGNC Official Full Name nucleophosmin 1 pseudogene 35provided by HGNC Primary source HGNC:HGNC:45214 See related AllianceGenome:HGNC:45214 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P36, Official Symbol NPM1P36provided by HGNC Official Full Name nucleophosmin 1 pseudogene 36provided by HGNC Primary source HGNC:HGNC:45215 See related Ensembl:ENSG00000214604 AllianceGenome:HGNC:45215 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P38, Official Symbol NPM1P38provided by HGNC Official Full Name nucleophosmin 1 pseudogene 38provided by HGNC Primary source HGNC:HGNC:45217 See related Ensembl:ENSG00000219257 AllianceGenome:HGNC:45217 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P39, Official Symbol NPM1P39provided by HGNC Official Full Name nucleophosmin 1 pseudogene 39provided by HGNC Primary source HGNC:HGNC:45218 See related Ensembl:ENSG00000225159 AllianceGenome:HGNC:45218 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P4, Official Symbol NPM1P4provided by HGNC Official Full Name nucleophosmin 1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:7924 See related AllianceGenome:HGNC:7924 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NG4-5; NPMP4
NPM1P40, Official Symbol NPM1P40provided by HGNC Official Full Name nucleophosmin 1 pseudogene 40provided by HGNC Primary source HGNC:HGNC:45219 See related Ensembl:ENSG00000236523 AllianceGenome:HGNC:45219 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P47, Official Symbol NPM1P47provided by HGNC Official Full Name nucleophosmin 1 pseudogene 47provided by HGNC Primary source HGNC:HGNC:45226 See related AllianceGenome:HGNC:45226 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P48, Official Symbol NPM1P48provided by HGNC Official Full Name nucleophosmin 1 pseudogene 48provided by HGNC Primary source HGNC:HGNC:45227 See related Ensembl:ENSG00000231821 AllianceGenome:HGNC:45227 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P49, Official Symbol NPM1P49provided by HGNC Official Full Name nucleophosmin 1 pseudogene 49provided by HGNC Primary source HGNC:HGNC:45228 See related Ensembl:ENSG00000226556 AllianceGenome:HGNC:45228 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P5, Official Symbol NPM1P5provided by HGNC Official Full Name nucleophosmin 1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:7925 See related AllianceGenome:HGNC:7925 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NG5-4; NPMP5
NPM1P50, Official Symbol NPM1P50provided by HGNC Official Full Name nucleophosmin 1 pseudogene 50provided by HGNC Primary source HGNC:HGNC:45229 See related Ensembl:ENSG00000213333 AllianceGenome:HGNC:45229 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P52, Official Symbol NPM1P52provided by HGNC Official Full Name nucleophosmin 1 pseudogene 52provided by HGNC Primary source HGNC:HGNC:45231 See related Ensembl:ENSG00000253663 AllianceGenome:HGNC:45231 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NPM1P7, Official Symbol NPM1P7provided by HGNC Official Full Name nucleophosmin 1 pseudogene 7provided by HGNC Primary source HGNC:HGNC:7927 See related AllianceGenome:HGNC:7927 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NG7-6; NPMP7; NPM1P16
NPM2, Official Symbol NPM2provided by HGNC Official Full Name nucleophosmin/nucleoplasmin 2provided by HGNC Primary source HGNC:HGNC:7930 See related Ensembl:ENSG00000158806 MIM:608073; AllianceGenome:HGNC:7930 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Involved in several processes, including blastocyst development; oocyte differentiation; and regulation of cell cycle process. Located in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 3.7), brain (RPKM 3.7) and 12 other tissues See more Orthologs mouse all
NPM3, Official Symbol NPM3provided by HGNC Official Full Name nucleophosmin/nucleoplasmin 3provided by HGNC Primary source HGNC:HGNC:7931 See related Ensembl:ENSG00000107833 MIM:606456; AllianceGenome:HGNC:7931 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PORMIN; TMEM123 Summary The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in testis (RPKM 11.1), appendix (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
NPNT, Official Symbol NPNTprovided by HGNC Official Full Name nephronectinprovided by HGNC Primary source HGNC:HGNC:27405 See related Ensembl:ENSG00000168743 MIM:610306; AllianceGenome:HGNC:27405 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POEM; EGFL6L Summary Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; positive regulation of ERK1 and ERK2 cascade; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular exosome. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 91.1), lung (RPKM 60.2) and 10 other tissues See more Orthologs mouse all
NPPA, Official Symbol NPPAprovided by HGNC Official Full Name natriuretic peptide Aprovided by HGNC Primary source HGNC:HGNC:7939 See related Ensembl:ENSG00000175206 MIM:108780; AllianceGenome:HGNC:7939 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF Summary The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015] Expression Restricted expression toward heart (RPKM 12159.5) See more Orthologs mouse all
NPPB, Official Symbol NPPBprovided by HGNC Official Full Name natriuretic peptide Bprovided by HGNC Primary source HGNC:HGNC:7940 See related Ensembl:ENSG00000120937 MIM:600295; AllianceGenome:HGNC:7940 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BNP; Iso-ANP Summary This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis. Expression Restricted expression toward heart (RPKM 1334.9) See more Orthologs mouse all
NPPC, Official Symbol NPPCprovided by HGNC Official Full Name natriuretic peptide Cprovided by HGNC Primary source HGNC:HGNC:7941 See related Ensembl:ENSG00000163273 MIM:600296; AllianceGenome:HGNC:7941 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNP; CNP2 Summary This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015] Annotation information Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018] Expression Biased expression in prostate (RPKM 1.1), esophagus (RPKM 0.4) and 9 other tissues See more Orthologs mouse all
NPR1, Official Symbol NPR1provided by HGNC Official Full Name natriuretic peptide receptor 1provided by HGNC Primary source HGNC:HGNC:7943 See related Ensembl:ENSG00000169418 MIM:108960; AllianceGenome:HGNC:7943 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANPa; NPRA; ANPRA; GUC2A; GUCY2A Summary Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] Expression Biased expression in fat (RPKM 49.0), lung (RPKM 10.4) and 9 other tissues See more Orthologs mouse all
NPR2, Official Symbol NPR2provided by HGNC Official Full Name natriuretic peptide receptor 2provided by HGNC Primary source HGNC:HGNC:7944 See related Ensembl:ENSG00000159899 MIM:108961; AllianceGenome:HGNC:7944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCB; AMD1; AMDM; ANPb; ECDM; GC-B; NPRB; SNSK; ANPRB; GUC2B; NPRBi; GUCY2B Summary This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 8.6), fat (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
NPR3, Official Symbol NPR3provided by HGNC Official Full Name natriuretic peptide receptor 3provided by HGNC Primary source HGNC:HGNC:7945 See related Ensembl:ENSG00000113389 MIM:108962; AllianceGenome:HGNC:7945 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPRC; ANP-C; ANPRC; BOMOS; NPR-C; ANPR-C; GUCY2B; C5orf23 Summary This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] Expression Biased expression in kidney (RPKM 35.4), fat (RPKM 14.2) and 8 other tissues See more Orthologs mouse all
NPRL2, Official Symbol NPRL2provided by HGNC Official Full Name NPR2 like, GATOR1 complex subunitprovided by HGNC Primary source HGNC:HGNC:24969 See related Ensembl:ENSG00000114388 MIM:607072; AllianceGenome:HGNC:24969 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPR2; NPR2L; TUSC4; FFEVF2 Summary Enables protein kinase activity. Contributes to GTPase activator activity. Involved in cellular response to amino acid starvation; negative regulation of TOR signaling; and negative regulation of kinase activity. Located in lysosomal membrane. Part of GATOR1 complex. Implicated in focal epilepsy. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 7.6), ovary (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
NPRL3, Official Symbol NPRL3provided by HGNC Official Full Name NPR3 like, GATOR1 complex subunitprovided by HGNC Primary source HGNC:HGNC:14124 See related Ensembl:ENSG00000103148 MIM:600928; AllianceGenome:HGNC:14124 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MARE; NPR3; HS-40; RMD11; CGTHBA; FFEVF3; C16orf35 Summary Contributes to GTPase activator activity. Involved in cellular response to amino acid starvation and negative regulation of TOR signaling. Located in lysosomal membrane. Part of GATOR1 complex. Implicated in focal epilepsy. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 11.3), ovary (RPKM 10.7) and 25 other tissues See more Orthologs mouse all
NPS, Official Symbol NPSprovided by HGNC Official Full Name neuropeptide Sprovided by HGNC Primary source HGNC:HGNC:33940 See related Ensembl:ENSG00000214285 MIM:609513; AllianceGenome:HGNC:33940 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in positive regulation of GABAergic synaptic transmission; positive regulation of action potential; and positive regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within visual learning. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
NPSR1, Official Symbol NPSR1provided by HGNC Official Full Name neuropeptide S receptor 1provided by HGNC Primary source HGNC:HGNC:23631 See related Ensembl:ENSG00000187258 MIM:608595; AllianceGenome:HGNC:23631 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154 Summary This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all
NPSR1-AS1, Official Symbol NPSR1-AS1provided by HGNC Official Full Name NPSR1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:22128 See related Ensembl:ENSG00000197085 MIM:608596; AllianceGenome:HGNC:22128 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAA1 Summary This gene is located within a region that has been associated with asthma susceptibility. The locus is considered non-protein-coding based on lack of protein homology and a lack of experimental support for an encoded protein. Three alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2010] Expression Low expression observed in reference dataset See more
NPTN, Official Symbol NPTNprovided by HGNC Official Full Name neuroplastinprovided by HGNC Primary source HGNC:HGNC:17867 See related Ensembl:ENSG00000156642 MIM:612820; AllianceGenome:HGNC:17867 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP55; GP65; SDR1; np55; np65; SDFR1 Summary This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009] Expression Ubiquitous expression in brain (RPKM 67.5), endometrium (RPKM 61.9) and 25 other tissues See more Orthologs mouse all
NPTN-IT1, Official Symbol NPTN-IT1provided by HGNC Official Full Name NPTN intronic transcript 1provided by HGNC Primary source HGNC:HGNC:45091 See related Ensembl:ENSG00000281183 MIM:615176; AllianceGenome:HGNC:45091 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as lncRNA-LET
NPTX1, Official Symbol NPTX1provided by HGNC Official Full Name neuronal pentraxin 1provided by HGNC Primary source HGNC:HGNC:7952 See related Ensembl:ENSG00000171246 MIM:602367; AllianceGenome:HGNC:7952 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NP1; SCA50 Summary NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 51.6) and adrenal (RPKM 2.1) See more Orthologs mouse all
NPTX2, Official Symbol NPTX2provided by HGNC Official Full Name neuronal pentraxin 2provided by HGNC Primary source HGNC:HGNC:7953 See related Ensembl:ENSG00000106236 MIM:600750; AllianceGenome:HGNC:7953 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NP2; NARP; NP-II Summary This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009] Expression Biased expression in brain (RPKM 31.6), testis (RPKM 20.6) and 4 other tissues See more Orthologs mouse all
NPTXR, Official Symbol NPTXRprovided by HGNC Official Full Name neuronal pentraxin receptorprovided by HGNC Primary source HGNC:HGNC:7954 See related Ensembl:ENSG00000221890 MIM:609474; AllianceGenome:HGNC:7954 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPR Summary This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 73.3), heart (RPKM 6.6) and 3 other tissues See more Orthologs mouse all
NPVF, Official Symbol NPVFprovided by HGNC Official Full Name neuropeptide VF precursorprovided by HGNC Primary source HGNC:HGNC:13782 See related Ensembl:ENSG00000105954 MIM:616984; AllianceGenome:HGNC:13782 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RFRP; C7orf9 Summary Predicted to enable signaling receptor binding activity. Involved in negative regulation of gonadotropin secretion. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
NPW, Official Symbol NPWprovided by HGNC Official Full Name neuropeptide Wprovided by HGNC Primary source HGNC:HGNC:30509 See related Ensembl:ENSG00000183971 MIM:607997; AllianceGenome:HGNC:30509 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L8; L8C; PPL8; PPNPW Summary The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 2.8), stomach (RPKM 0.8) and 1 other tissue See more Orthologs mouse all
NPY, Official Symbol NPYprovided by HGNC Official Full Name neuropeptide Yprovided by HGNC Primary source HGNC:HGNC:7955 See related Ensembl:ENSG00000122585 MIM:162640; AllianceGenome:HGNC:7955 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PYY4 Summary This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] Expression Biased expression in prostate (RPKM 182.5), brain (RPKM 56.2) and 1 other tissue See more Orthologs mouse all
NPY1R, Official Symbol NPY1Rprovided by HGNC Official Full Name neuropeptide Y receptor Y1provided by HGNC Primary source HGNC:HGNC:7956 See related Ensembl:ENSG00000164128 MIM:162641; AllianceGenome:HGNC:7956 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPYR; NPY1-R Summary This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013] Expression Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues See more Orthologs mouse all
NPY2R, Official Symbol NPY2Rprovided by HGNC Official Full Name neuropeptide Y receptor Y2provided by HGNC Primary source HGNC:HGNC:7957 See related Ensembl:ENSG00000185149 MIM:162642; AllianceGenome:HGNC:7957 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPY2-R Summary Predicted to enable calcium channel regulator activity and neuropeptide Y receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
NPY4R, Official Symbol NPY4Rprovided by HGNC Official Full Name neuropeptide Y receptor Y4provided by HGNC Primary source HGNC:HGNC:9329 See related Ensembl:ENSG00000204174 MIM:601790; AllianceGenome:HGNC:9329 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Y4; PP1; PPYR1; NPY4-R Summary Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 2.9), skin (RPKM 1.7) and 7 other tissues See more Orthologs mouse all
NPY4R2, Official Symbol NPY4R2provided by HGNC Official Full Name neuropeptide Y receptor Y4-2provided by HGNC Primary source HGNC:HGNC:52383 See related Ensembl:ENSG00000264717 AllianceGenome:HGNC:52383 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP1; NPY4R; PPYR1; NPY4-R; CH17-360D5.1 Summary Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 2.8), skin (RPKM 1.5) and 7 other tissues See more Orthologs all
NPY5R, Official Symbol NPY5Rprovided by HGNC Official Full Name neuropeptide Y receptor Y5provided by HGNC Primary source HGNC:HGNC:7958 See related Ensembl:ENSG00000164129 MIM:602001; AllianceGenome:HGNC:7958 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPYR5; NPY5-R; NPYY5-R Summary The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015] Expression Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues See more Orthologs mouse all
NPY6R, Official Symbol NPY6Rprovided by HGNC Official Full Name neuropeptide Y receptor Y6 (pseudogene)provided by HGNC Primary source HGNC:HGNC:7959 See related Ensembl:ENSG00000226306 MIM:601770; AllianceGenome:HGNC:7959 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2; Y2B; NPY1RL; NPY6RP Summary Predicted to enable pancreatic polypeptide receptor activity and peptide YY receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in heart (RPKM 55.5), duodenum (RPKM 9.3) and 5 other tissues See more