psui3905/ncbi_genes_summary huggingface dataset:
WNT16, Official Symbol WNT16provided by HGNC Official Full Name Wnt family member 16provided by HGNC Primary source HGNC:HGNC:16267 See related Ensembl:ENSG00000002745 MIM:606267; AllianceGenome:HGNC:16267 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 9.9) and lymph node (RPKM 0.5) See more Orthologs mouse all
WNT2, Official Symbol WNT2provided by HGNC Official Full Name Wnt family member 2provided by HGNC Primary source HGNC:HGNC:12780 See related Ensembl:ENSG00000105989 MIM:147870; AllianceGenome:HGNC:12780 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRP; INT1L1 Summary This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 44.0), endometrium (RPKM 14.0) and 3 other tissues See more Orthologs mouse all
WNT2B, Official Symbol WNT2Bprovided by HGNC Official Full Name Wnt family member 2Bprovided by HGNC Primary source HGNC:HGNC:12781 See related Ensembl:ENSG00000134245 MIM:601968; AllianceGenome:HGNC:12781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WNT13 Summary This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Broad expression in ovary (RPKM 4.3), skin (RPKM 3.1) and 21 other tissues See more Orthologs mouse all
WNT3, Official Symbol WNT3provided by HGNC Official Full Name Wnt family member 3provided by HGNC Primary source HGNC:HGNC:12782 See related Ensembl:ENSG00000108379 MIM:165330; AllianceGenome:HGNC:12782 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT4; TETAMS Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 21.7), testis (RPKM 3.1) and 3 other tissues See more Orthologs mouse all
WNT3A, Official Symbol WNT3Aprovided by HGNC Official Full Name Wnt family member 3Aprovided by HGNC Primary source HGNC:HGNC:15983 See related Ensembl:ENSG00000154342 MIM:606359; AllianceGenome:HGNC:15983 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 9.0), lung (RPKM 1.6) and 1 other tissue See more Orthologs mouse all
WNT4, Official Symbol WNT4provided by HGNC Official Full Name Wnt family member 4provided by HGNC Primary source HGNC:HGNC:12783 See related Ensembl:ENSG00000162552 MIM:603490; AllianceGenome:HGNC:12783 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WNT-4; SERKAL Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 8.0), ovary (RPKM 4.5) and 13 other tissues See more Orthologs mouse all
WNT5A, Official Symbol WNT5Aprovided by HGNC Official Full Name Wnt family member 5Aprovided by HGNC Primary source HGNC:HGNC:12784 See related Ensembl:ENSG00000114251 MIM:164975; AllianceGenome:HGNC:12784 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hWNT5A Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] Expression Broad expression in urinary bladder (RPKM 9.1), endometrium (RPKM 7.3) and 19 other tissues See more Orthologs mouse all
WNT5B, Official Symbol WNT5Bprovided by HGNC Official Full Name Wnt family member 5Bprovided by HGNC Primary source HGNC:HGNC:16265 See related Ensembl:ENSG00000111186 MIM:606361; AllianceGenome:HGNC:16265 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] Expression Broad expression in prostate (RPKM 12.1), esophagus (RPKM 5.6) and 21 other tissues See more Orthologs mouse all
WNT6, Official Symbol WNT6provided by HGNC Official Full Name Wnt family member 6provided by HGNC Primary source HGNC:HGNC:12785 See related Ensembl:ENSG00000115596 MIM:604663; AllianceGenome:HGNC:12785 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 1.4), prostate (RPKM 1.1) and 13 other tissues See more Orthologs mouse all
WNT7A, Official Symbol WNT7Aprovided by HGNC Official Full Name Wnt family member 7Aprovided by HGNC Primary source HGNC:HGNC:12786 See related Ensembl:ENSG00000154764 MIM:601570; AllianceGenome:HGNC:12786 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Wnt-7a Summary This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 3.1), placenta (RPKM 2.3) and 9 other tissues See more Orthologs mouse all
WNT7B, Official Symbol WNT7Bprovided by HGNC Official Full Name Wnt family member 7Bprovided by HGNC Primary source HGNC:HGNC:12787 See related Ensembl:ENSG00000188064 MIM:601967; AllianceGenome:HGNC:12787 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008] Expression Biased expression in skin (RPKM 7.3), urinary bladder (RPKM 3.8) and 6 other tissues See more Orthologs mouse all
WNT8A, Official Symbol WNT8Aprovided by HGNC Official Full Name Wnt family member 8Aprovided by HGNC Primary source HGNC:HGNC:12788 See related Ensembl:ENSG00000061492 MIM:606360; AllianceGenome:HGNC:12788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WNT8D Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all
WNT8B, Official Symbol WNT8Bprovided by HGNC Official Full Name Wnt family member 8Bprovided by HGNC Primary source HGNC:HGNC:12789 See related Ensembl:ENSG00000075290 MIM:601396; AllianceGenome:HGNC:12789 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
WNT9A, Official Symbol WNT9Aprovided by HGNC Official Full Name Wnt family member 9Aprovided by HGNC Primary source HGNC:HGNC:12778 See related Ensembl:ENSG00000143816 MIM:602863; AllianceGenome:HGNC:12778 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WNT14 Summary The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008] Expression Broad expression in heart (RPKM 3.6), endometrium (RPKM 2.9) and 21 other tissues See more Orthologs mouse all
WNT9B, Official Symbol WNT9Bprovided by HGNC Official Full Name Wnt family member 9Bprovided by HGNC Primary source HGNC:HGNC:12779 See related Ensembl:ENSG00000158955 MIM:602864; AllianceGenome:HGNC:12779 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WNT15; WNT14B Summary The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Biased expression in kidney (RPKM 1.6), skin (RPKM 0.7) and 9 other tissues See more Orthologs mouse all
WRAP53, Official Symbol WRAP53provided by HGNC Official Full Name WD repeat containing antisense to TP53provided by HGNC Primary source HGNC:HGNC:25522 See related Ensembl:ENSG00000141499 MIM:612661; AllianceGenome:HGNC:25522 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKCB3; TCAB1; WDR79 Summary This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011] Expression Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues See more Orthologs mouse all
WRAP73, Official Symbol WRAP73provided by HGNC Official Full Name WD repeat containing, antisense to TP73provided by HGNC Primary source HGNC:HGNC:12759 See related Ensembl:ENSG00000116213 MIM:606040; AllianceGenome:HGNC:12759 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WDR8 Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in bone marrow (RPKM 7.8), testis (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
WRN, Official Symbol WRNprovided by HGNC Official Full Name WRN RecQ like helicaseprovided by HGNC Primary source HGNC:HGNC:12791 See related Ensembl:ENSG00000165392 MIM:604611; AllianceGenome:HGNC:12791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RECQ3; RECQL2; RECQL3 Summary This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in bone marrow (RPKM 5.0), endometrium (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
WRNIP1, Official Symbol WRNIP1provided by HGNC Official Full Name WRN helicase interacting protein 1provided by HGNC Primary source HGNC:HGNC:20876 See related Ensembl:ENSG00000124535 MIM:608196; AllianceGenome:HGNC:20876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WHIP; FAP93; CFAP93; bA420G6.2 Summary Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 15.6), placenta (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
WSB1, Official Symbol WSB1provided by HGNC Official Full Name WD repeat and SOCS box containing 1provided by HGNC Primary source HGNC:HGNC:19221 See related Ensembl:ENSG00000109046 MIM:610091; AllianceGenome:HGNC:19221 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SWIP1; WSB-1 Summary This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 64.5), lung (RPKM 63.6) and 25 other tissues See more Orthologs mouse all
WSB2, Official Symbol WSB2provided by HGNC Official Full Name WD repeat and SOCS box containing 2provided by HGNC Primary source HGNC:HGNC:19222 See related Ensembl:ENSG00000176871 AllianceGenome:HGNC:19222 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SBA2 Summary This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 28.5) and 25 other tissues See more Orthologs mouse all
WSCD1, Official Symbol WSCD1provided by HGNC Official Full Name WSC domain containing 1provided by HGNC Primary source HGNC:HGNC:29060 See related Ensembl:ENSG00000179314 MIM:619584; AllianceGenome:HGNC:29060 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable sulfotransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 6.9), spleen (RPKM 4.6) and 14 other tissues See more Orthologs mouse all
WSCD2, Official Symbol WSCD2provided by HGNC Official Full Name WSC domain containing 2provided by HGNC Primary source HGNC:HGNC:29117 See related Ensembl:ENSG00000075035 MIM:619253; AllianceGenome:HGNC:29117 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 7.6), brain (RPKM 4.6) and 4 other tissues See more Orthologs mouse all
WSPAR, Official Symbol WSPARprovided by HGNC Official Full Name WNT signaling pathway activating non-coding RNAprovided by HGNC Primary source HGNC:HGNC:51639 See related Ensembl:ENSG00000249073 MIM:616333; AllianceGenome:HGNC:51639 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LncTCF7; TCONS_00009511 Expression Low expression observed in reference dataset See more
WT1, Official Symbol WT1provided by HGNC Official Full Name WT1 transcription factorprovided by HGNC Primary source HGNC:HGNC:12796 See related Ensembl:ENSG00000184937 MIM:607102; AllianceGenome:HGNC:12796 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GUD; AWT1; WAGR; WT-1; WT33; NPHS4; WIT-2 Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015] Expression Biased expression in endometrium (RPKM 27.6), testis (RPKM 17.6) and 4 other tissues See more Orthologs mouse all
WT1-AS, Official Symbol WT1-ASprovided by HGNC Official Full Name WT1 antisense RNAprovided by HGNC Primary source HGNC:HGNC:18135 See related Ensembl:ENSG00000183242 MIM:607899; AllianceGenome:HGNC:18135 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WIT1; WIT-1; WT1AS; WT1-AS1 Summary This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis. [provided by RefSeq, May 2014] Expression Biased expression in ovary (RPKM 4.7), endometrium (RPKM 3.7) and 3 other tissues See more Orthologs mouse all
WTAP, Official Symbol WTAPprovided by HGNC Official Full Name WT1 associated proteinprovided by HGNC Primary source HGNC:HGNC:16846 See related Ensembl:ENSG00000146457 MIM:605442; AllianceGenome:HGNC:16846 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mum2 Summary The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in bone marrow (RPKM 44.8), lymph node (RPKM 20.4) and 25 other tissues See more Orthologs mouse all
WTAPP1, Official Symbol WTAPP1provided by HGNC Official Full Name Wilms tumor 1 associated protein pseudogene 1provided by HGNC Primary source HGNC:HGNC:44115 See related Ensembl:ENSG00000255282 AllianceGenome:HGNC:44115 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in gall bladder (RPKM 3.0), appendix (RPKM 1.1) and 8 other tissues See more
WTIP, Official Symbol WTIPprovided by HGNC Official Full Name WT1 interacting proteinprovided by HGNC Primary source HGNC:HGNC:20964 See related Ensembl:ENSG00000142279 MIM:614790; AllianceGenome:HGNC:20964 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of gene silencing by miRNA; and response to hypoxia. Acts upstream of or within gene silencing by miRNA. Located in P-body. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 6.5), ovary (RPKM 5.4) and 23 other tissues See more Orthologs mouse all
WWC1, Official Symbol WWC1provided by HGNC Official Full Name WW and C2 domain containing 1provided by HGNC Primary source HGNC:HGNC:29435 See related Ensembl:ENSG00000113645 MIM:610533; AllianceGenome:HGNC:29435 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168 Summary The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Broad expression in salivary gland (RPKM 17.1), kidney (RPKM 16.5) and 17 other tissues See more Orthologs mouse all
WWC2, Official Symbol WWC2provided by HGNC Official Full Name WW and C2 domain containing 2provided by HGNC Primary source HGNC:HGNC:24148 See related Ensembl:ENSG00000151718 MIM:620110; AllianceGenome:HGNC:24148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BOMB Summary This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016] Expression Broad expression in lung (RPKM 16.2), kidney (RPKM 8.8) and 23 other tissues See more Orthologs mouse all
WWC2-AS1, Official Symbol WWC2-AS1provided by HGNC Official Full Name WWC2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41041 See related Ensembl:ENSG00000251128 MIM:620088; AllianceGenome:HGNC:41041 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
WWC2-AS2, Official Symbol WWC2-AS2provided by HGNC Official Full Name WWC2 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:26390 See related Ensembl:ENSG00000251359 AllianceGenome:HGNC:26390 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C4orf38
WWC3, Official Symbol WWC3provided by HGNC Official Full Name WWC family member 3provided by HGNC Primary source HGNC:HGNC:29237 See related Ensembl:ENSG00000047644 MIM:301089; AllianceGenome:HGNC:29237 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BM042 Summary This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011] Annotation information Annotation category: suggests misassembly Expression Ubiquitous expression in lung (RPKM 15.2), placenta (RPKM 10.3) and 25 other tissues See more Orthologs all
WWOX, Official Symbol WWOXprovided by HGNC Official Full Name WW domain containing oxidoreductaseprovided by HGNC Primary source HGNC:HGNC:12799 See related Ensembl:ENSG00000186153 MIM:605131; AllianceGenome:HGNC:12799 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOR; WOX1; DEE28; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in thyroid (RPKM 4.4), kidney (RPKM 2.1) and 25 other tissues See more Orthologs mouse all
WWOX-AS1, Official Symbol WWOX-AS1provided by HGNC Official Full Name WWOX antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53169 See related Ensembl:ENSG00000260969 AllianceGenome:HGNC:53169 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 5.3) See more
WWP1, Official Symbol WWP1provided by HGNC Official Full Name WW domain containing E3 ubiquitin protein ligase 1provided by HGNC Primary source HGNC:HGNC:17004 See related Ensembl:ENSG00000123124 MIM:602307; AllianceGenome:HGNC:17004 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIP5; Tiul1; hSDRP1 Summary WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues See more Orthologs mouse all
WWP1P1, Official Symbol WWP1P1provided by HGNC Official Full Name WW domain containing E3 ubiquitin protein ligase 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:48944 See related AllianceGenome:HGNC:48944 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
WWP2, Official Symbol WWP2provided by HGNC Official Full Name WW domain containing E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:16804 See related Ensembl:ENSG00000198373 MIM:602308; AllianceGenome:HGNC:16804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AIP2; WWp2-like Summary This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in lung (RPKM 8.8), spleen (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
WWTR1, Official Symbol WWTR1provided by HGNC Official Full Name WW domain containing transcription regulator 1provided by HGNC Primary source HGNC:HGNC:24042 See related Ensembl:ENSG00000018408 MIM:607392; AllianceGenome:HGNC:24042 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAZ Summary Enables transcription coactivator activity. Involved in several processes, including hippo signaling; positive regulation of cell differentiation; and regulation of signal transduction. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: TAZ (GeneID 6901) and WWTR1 (GeneID 25937) loci share the TAZ symbol/alias in common. TAZ is a widely used alternative name for the transcriptional coactivator with PDZ-binding motif (WWTR1) conflicting with the official symbol for tafazzin (TAZ). [19 Jun 2012] Expression Ubiquitous expression in gall bladder (RPKM 24.8), endometrium (RPKM 22.7) and 24 other tissues See more Orthologs mouse all
WWTR1-AS1, Official Symbol WWTR1-AS1provided by HGNC Official Full Name WWTR1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41035 See related Ensembl:ENSG00000241313 AllianceGenome:HGNC:41035 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
XAB2, Official Symbol XAB2provided by HGNC Official Full Name XPA binding protein 2provided by HGNC Primary source HGNC:HGNC:14089 See related Ensembl:ENSG00000076924 MIM:610850; AllianceGenome:HGNC:14089 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCNP; HCRN; SYF1; NTC90 Summary Involved in mRNA splicing, via spliceosome; transcription, DNA-templated; and transcription-coupled nucleotide-excision repair. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 21.5), ovary (RPKM 19.8) and 25 other tissues See more Orthologs mouse all
XAF1, Official Symbol XAF1provided by HGNC Official Full Name XIAP associated factor 1provided by HGNC Primary source HGNC:HGNC:30932 See related Ensembl:ENSG00000132530 MIM:606717; AllianceGenome:HGNC:30932 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIRC4BP; XIAPAF1; HSXIAPAF1 Summary This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in spleen (RPKM 13.4), lung (RPKM 8.3) and 24 other tissues See more Orthologs mouse all
XAGE1A, Official Symbol XAGE1Aprovided by HGNC Official Full Name X antigen family member 1Aprovided by HGNC Primary source HGNC:HGNC:4111 See related Ensembl:ENSG00000204379 MIM:300742; AllianceGenome:HGNC:4111 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTP9; XAGE1; CT12.1; GAGED2; XAGE-1; XAGE1B; CT12.1A; CT12.1B Summary This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010] Annotation information Note: There are two XAGE1 loci on the X chromosome. This location, previously annotated as XAGE1B, is now annotated as XAGE1A. [01 Dec 2017] Expression Restricted expression toward testis (RPKM 23.8) See more Orthologs all
XAGE1B, Official Symbol XAGE1Bprovided by HGNC Official Full Name X antigen family member 1Bprovided by HGNC Primary source HGNC:HGNC:25400 See related Ensembl:ENSG00000204382 MIM:300289; AllianceGenome:HGNC:25400 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTP9; XAGE1; CT12.1; GAGED2; XAGE-1; XAGE1C; XAGE1D; XAGE1E; CT12.1C; CT12.1D; CT12.1E; CT12.1b Summary This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010] Annotation information Note: There are two XAGE1 loci on the X chromosome. This location, previously annotated as XAGE1E, is now annotated as XAGE1B. [01 Dec 2017] Expression Restricted expression toward testis (RPKM 23.6) See more Orthologs all