psui3905/ncbi_genes_summary huggingface dataset:
HBP1, Official Symbol HBP1provided by HGNC Official Full Name HMG-box transcription factor 1provided by HGNC Primary source HGNC:HGNC:23200 See related Ensembl:ENSG00000105856 MIM:616714; AllianceGenome:HGNC:23200 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of lipid transport; negative regulation of reactive oxygen species biosynthetic process; and negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Biomarker of osteoarthritis. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 32.0), endometrium (RPKM 26.6) and 25 other tissues See more Orthologs mouse all
HBQ1, Official Symbol HBQ1provided by HGNC Official Full Name hemoglobin subunit theta 1provided by HGNC Primary source HGNC:HGNC:4833 See related Ensembl:ENSG00000086506 MIM:142240; AllianceGenome:HGNC:4833 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBQ Summary Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008] Orthologs mouse all
HBS1L, Official Symbol HBS1Lprovided by HGNC Official Full Name HBS1 like translational GTPaseprovided by HGNC Primary source HGNC:HGNC:4834 See related Ensembl:ENSG00000112339 MIM:612450; AllianceGenome:HGNC:4834 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERFS; HBS1; EF-1a; eRF3c; HSPC276 Summary This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009] Expression Ubiquitous expression in bone marrow (RPKM 6.5), brain (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
HBZ, Official Symbol HBZprovided by HGNC Official Full Name hemoglobin subunit zetaprovided by HGNC Primary source HGNC:HGNC:4835 See related Ensembl:ENSG00000130656 MIM:142310; AllianceGenome:HGNC:4835 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBAZ; HBZ1; HBZ-T1 Summary Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009] Expression Biased expression in testis (RPKM 1.3), bone marrow (RPKM 0.5) and 1 other tissue See more Orthologs mouse all
HBZP1, Official Symbol HBZP1provided by HGNC Official Full Name hemoglobin subunit zeta pseudogene 1provided by HGNC Primary source HGNC:HGNC:4836 See related Ensembl:ENSG00000206178 AllianceGenome:HGNC:4836 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBZ2; HBZP; HBZ2P; HBZ-T2
HCAR1, Official Symbol HCAR1provided by HGNC Official Full Name hydroxycarboxylic acid receptor 1provided by HGNC Primary source HGNC:HGNC:4532 See related Ensembl:ENSG00000196917 MIM:606923; AllianceGenome:HGNC:4532 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCA1; GPR81; LACR1; FKSG80; GPR104; TAGPCR; TA-GPCR Summary G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005] Orthologs mouse all
HCAR2, Official Symbol HCAR2provided by HGNC Official Full Name hydroxycarboxylic acid receptor 2provided by HGNC Primary source HGNC:HGNC:24827 See related Ensembl:ENSG00000182782 MIM:609163; AllianceGenome:HGNC:24827 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A Summary Predicted to enable nicotinic acid receptor activity. Involved in neutrophil apoptotic process and positive regulation of neutrophil apoptotic process. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
HCAR3, Official Symbol HCAR3provided by HGNC Official Full Name hydroxycarboxylic acid receptor 3provided by HGNC Primary source HGNC:HGNC:16824 See related Ensembl:ENSG00000255398 MIM:606039; AllianceGenome:HGNC:16824 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCA3; HM74; PUMAG; Puma-g; GPR109B Summary Predicted to enable GTP binding activity and purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
HCCAT5, Official Symbol HCCAT5provided by HGNC Official Full Name hepatocellular carcinoma associated transcript 5provided by HGNC Primary source HGNC:HGNC:48612 See related Ensembl:ENSG00000260880 MIM:615613; AllianceGenome:HGNC:48612 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTA; FJ222407 Expression Low expression observed in reference dataset See more
HCCS, Official Symbol HCCSprovided by HGNC Official Full Name holocytochrome c synthaseprovided by HGNC Primary source HGNC:HGNC:4837 See related Ensembl:ENSG00000004961 MIM:300056; AllianceGenome:HGNC:4837 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLS; CCHL; MCOPS7; LSDMCA1 Summary The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010] Expression Ubiquitous expression in heart (RPKM 12.9), colon (RPKM 8.9) and 25 other tissues See more Orthologs mouse all
HCFC1, Official Symbol HCFC1provided by HGNC Official Full Name host cell factor C1provided by HGNC Primary source HGNC:HGNC:4839 See related Ensembl:ENSG00000172534 MIM:300019; AllianceGenome:HGNC:4839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; MAHCX; XLID3; PPP1R89 Summary This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 11.5), spleen (RPKM 8.5) and 25 other tissues See more Orthologs mouse all
HCFC1-AS1, Official Symbol HCFC1-AS1provided by HGNC Official Full Name HCFC1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40273 See related AllianceGenome:HGNC:40273 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
HCFC1R1, Official Symbol HCFC1R1provided by HGNC Official Full Name host cell factor C1 regulator 1provided by HGNC Primary source HGNC:HGNC:21198 See related Ensembl:ENSG00000103145 MIM:618818; AllianceGenome:HGNC:21198 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPIP Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 18.6), prostate (RPKM 18.2) and 25 other tissues See more Orthologs mouse all
HCFC2, Official Symbol HCFC2provided by HGNC Official Full Name host cell factor C2provided by HGNC Primary source HGNC:HGNC:24972 See related Ensembl:ENSG00000111727 MIM:607926; AllianceGenome:HGNC:24972 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCF2; HCF-2 Summary This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 10.0), endometrium (RPKM 3.8) and 25 other tissues See more Orthologs mouse all
HCFC2P1, Official Symbol HCFC2P1provided by HGNC Official Full Name host cell factor C2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39815 See related Ensembl:ENSG00000232087 AllianceGenome:HGNC:39815 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HCG11, Official Symbol HCG11provided by HGNC Official Full Name HLA complex group 11provided by HGNC Primary source HGNC:HGNC:17707 See related Ensembl:ENSG00000228223 AllianceGenome:HGNC:17707 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bK14H9.3; CTA-14H9.3
HCG14, Official Symbol HCG14provided by HGNC Official Full Name HLA complex group 14provided by HGNC Primary source HGNC:HGNC:18323 See related Ensembl:ENSG00000224157 AllianceGenome:HGNC:18323 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ111M5.4 Expression Low expression observed in reference dataset See more
HCG17, Official Symbol HCG17provided by HGNC Official Full Name HLA complex group 17provided by HGNC Primary source HGNC:HGNC:31339 See related Ensembl:ENSG00000270604 AllianceGenome:HGNC:31339 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCG18; LINC00046; NCRNA00046 Expression Low expression observed in reference dataset See more
HCG18, Official Symbol HCG18provided by HGNC Official Full Name HLA complex group 18provided by HGNC Primary source HGNC:HGNC:31337 See related Ensembl:ENSG00000231074 AllianceGenome:HGNC:31337 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 4.5), thyroid (RPKM 4.0) and 25 other tissues See more
HCG19P, Official Symbol HCG19Pprovided by HGNC Official Full Name HLA complex group 19 pseudogeneprovided by HGNC Primary source HGNC:HGNC:31336 Gene type pseudo Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
HCG20, Official Symbol HCG20provided by HGNC Official Full Name HLA complex group 20provided by HGNC Primary source HGNC:HGNC:31334 See related Ensembl:ENSG00000228022 AllianceGenome:HGNC:31334 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCRNA00149 Expression Broad expression in kidney (RPKM 1.8), colon (RPKM 1.5) and 25 other tissues See more
HCG22, Official Symbol HCG22provided by HGNC Official Full Name HLA complex group 22 (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:27780 See related Ensembl:ENSG00000228789 MIM:613918; AllianceGenome:HGNC:27780 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PBMUCL2 Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Annotation category: suggests misassembly Expression Biased expression in esophagus (RPKM 10.7) and brain (RPKM 0.7) See more
HCG25, Official Symbol HCG25provided by HGNC Official Full Name HLA complex group 25provided by HGNC Primary source HGNC:HGNC:20196 See related Ensembl:ENSG00000232940 AllianceGenome:HGNC:20196 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ1033B10.16 Expression Ubiquitous expression in skin (RPKM 11.4), prostate (RPKM 11.1) and 25 other tissues See more
HCG27, Official Symbol HCG27provided by HGNC Official Full Name HLA complex group 27provided by HGNC Primary source HGNC:HGNC:27366 See related Ensembl:ENSG00000206344 AllianceGenome:HGNC:27366 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bCX101P6.9; bPG299F13.9; bQB115I13.2 Expression Broad expression in spleen (RPKM 2.2), appendix (RPKM 1.9) and 25 other tissues See more
HCG4P11, Official Symbol HCG4P11provided by HGNC Official Full Name HLA complex group 4 pseudogene 11provided by HGNC Primary source HGNC:HGNC:22930 See related AllianceGenome:HGNC:22930 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCGIV-11; HCGIV.10
HCG4P3, Official Symbol HCG4P3provided by HGNC Official Full Name HLA complex group 4 pseudogene 3provided by HGNC Primary source HGNC:HGNC:22922 See related AllianceGenome:HGNC:22922 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCGIV-3; HCGIV.2; HCGIV-03
HCG4P5, Official Symbol HCG4P5provided by HGNC Official Full Name HLA complex group 4 pseudogene 5provided by HGNC Primary source HGNC:HGNC:22925 See related AllianceGenome:HGNC:22925 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCGIV-5; HCGIV.4; HCGIV-05
HCG4P7, Official Symbol HCG4P7provided by HGNC Official Full Name HLA complex group 4 pseudogene 7provided by HGNC Primary source HGNC:HGNC:22926 See related AllianceGenome:HGNC:22926 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCGIV-7; HCGIV.C; HCGIV-07
HCG9, Official Symbol HCG9provided by HGNC Official Full Name HLA complex group 9provided by HGNC Primary source HGNC:HGNC:21243 See related Ensembl:ENSG00000204625 MIM:615797; AllianceGenome:HGNC:21243 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCGIX; HCGIX4 Summary This gene lies within the MHC class I region on chromosome 6p21.3. This gene is believed to be non-coding, but its function has not been determined. [provided by RefSeq, Jul 2009] Expression Low expression observed in reference dataset See more
HCK, Official Symbol HCKprovided by HGNC Official Full Name HCK proto-oncogene, Src family tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:4840 See related Ensembl:ENSG00000101336 MIM:142370; AllianceGenome:HGNC:4840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JTK9; AIPCV; p59Hck; p61Hck Summary The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010] Expression Broad expression in appendix (RPKM 55.1), spleen (RPKM 40.9) and 14 other tissues See more Orthologs mouse all
HCLS1, Official Symbol HCLS1provided by HGNC Official Full Name hematopoietic cell-specific Lyn substrate 1provided by HGNC Primary source HGNC:HGNC:4844 See related Ensembl:ENSG00000180353 MIM:601306; AllianceGenome:HGNC:4844 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HS1; p75; CTTNL; lckBP1 Summary Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 118.5), lymph node (RPKM 107.3) and 16 other tissues See more Orthologs mouse all
HCN1, Official Symbol HCN1provided by HGNC Official Full Name hyperpolarization activated cyclic nucleotide gated potassium channel 1provided by HGNC Primary source HGNC:HGNC:4845 See related Ensembl:ENSG00000164588 MIM:602780; AllianceGenome:HGNC:4845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCNG1; DEE24; HAC-2; BCNG-1; EIEE24; GEFSP10 Summary The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011] Expression Biased expression in brain (RPKM 4.9), heart (RPKM 0.8) and 1 other tissue See more Orthologs mouse all
HCN2, Official Symbol HCN2provided by HGNC Official Full Name hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2provided by HGNC Primary source HGNC:HGNC:4846 See related Ensembl:ENSG00000099822 MIM:602781; AllianceGenome:HGNC:4846 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FEB2; BCNG2; EIG17; HAC-1; BCNG-2; GEFSP11 Summary The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017] Expression Biased expression in brain (RPKM 15.0), heart (RPKM 4.6) and 2 other tissues See more Orthologs mouse all
HCN3, Official Symbol HCN3provided by HGNC Official Full Name hyperpolarization activated cyclic nucleotide gated potassium channel 3provided by HGNC Primary source HGNC:HGNC:19183 See related Ensembl:ENSG00000143630 MIM:609973; AllianceGenome:HGNC:19183 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in liver (RPKM 3.6), duodenum (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
HCN4, Official Symbol HCN4provided by HGNC Official Full Name hyperpolarization activated cyclic nucleotide gated potassium channel 4provided by HGNC Primary source HGNC:HGNC:16882 See related Ensembl:ENSG00000138622 MIM:605206; AllianceGenome:HGNC:16882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SSS2; EIG18; BRGDA8 Summary This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008] Expression Biased expression in testis (RPKM 3.3), heart (RPKM 1.0) and 3 other tissues See more Orthologs mouse all
HCP5, Official Symbol HCP5provided by HGNC Official Full Name HLA complex P5provided by HGNC Primary source HGNC:HGNC:21659 See related Ensembl:ENSG00000206337 MIM:604676; AllianceGenome:HGNC:21659 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P5-1; 6S2650E; D6S2650E Expression Broad expression in spleen (RPKM 38.9), lymph node (RPKM 31.9) and 24 other tissues See more
HCP5B, Official Symbol HCP5Bprovided by HGNC Official Full Name HLA complex P5Bprovided by HGNC Primary source HGNC:HGNC:30984 See related Ensembl:ENSG00000281831 AllianceGenome:HGNC:30984 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P5.9; P5-10; HCP5P10
HCRT, Official Symbol HCRTprovided by HGNC Official Full Name hypocretin neuropeptide precursorprovided by HGNC Primary source HGNC:HGNC:4847 See related Ensembl:ENSG00000161610 MIM:602358; AllianceGenome:HGNC:4847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OX; PPOX; NRCLP1 Summary This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
HCRTR1, Official Symbol HCRTR1provided by HGNC Official Full Name hypocretin receptor 1provided by HGNC Primary source HGNC:HGNC:4848 See related Ensembl:ENSG00000121764 MIM:602392; AllianceGenome:HGNC:4848 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OX1R; OXR1; ORXR1 Summary The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all
HCRTR2, Official Symbol HCRTR2provided by HGNC Official Full Name hypocretin receptor 2provided by HGNC Primary source HGNC:HGNC:4849 See related Ensembl:ENSG00000137252 MIM:602393; AllianceGenome:HGNC:4849 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OX2R; OXR2; ORXR2 Summary The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all
HCST, Official Symbol HCSTprovided by HGNC Official Full Name hematopoietic cell signal transducerprovided by HGNC Primary source HGNC:HGNC:16977 See related Ensembl:ENSG00000126264 MIM:604089; AllianceGenome:HGNC:16977 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAP10; KAP10; PIK3AP Summary This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 39.5), spleen (RPKM 20.3) and 12 other tissues See more Orthologs mouse all
HDAC1, Official Symbol HDAC1provided by HGNC Official Full Name histone deacetylase 1provided by HGNC Primary source HGNC:HGNC:4852 See related Ensembl:ENSG00000116478 MIM:601241; AllianceGenome:HGNC:4852 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD1; RPD3; KDAC1; GON-10; RPD3L1 Summary Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 56.9), colon (RPKM 56.3) and 25 other tissues See more Orthologs mouse all
HDAC10, Official Symbol HDAC10provided by HGNC Official Full Name histone deacetylase 10provided by HGNC Primary source HGNC:HGNC:18128 See related Ensembl:ENSG00000100429 MIM:608544; AllianceGenome:HGNC:18128 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD10 Summary The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in spleen (RPKM 10.7), bone marrow (RPKM 7.4) and 25 other tissues See more Orthologs mouse all
HDAC11, Official Symbol HDAC11provided by HGNC Official Full Name histone deacetylase 11provided by HGNC Primary source HGNC:HGNC:19086 See related Ensembl:ENSG00000163517 MIM:607226; AllianceGenome:HGNC:19086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD11 Summary This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009] Expression Broad expression in brain (RPKM 17.4), testis (RPKM 14.8) and 22 other tissues See more Orthologs mouse all
HDAC11-AS1, Official Symbol HDAC11-AS1provided by HGNC Official Full Name HDAC11 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40868 See related Ensembl:ENSG00000244502 AllianceGenome:HGNC:40868 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 2.4) and kidney (RPKM 0.2) See more
HDAC1P1, Official Symbol HDAC1P1provided by HGNC Official Full Name histone deacetylase 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:45190 See related AllianceGenome:HGNC:45190 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HDAC1P2, Official Symbol HDAC1P2provided by HGNC Official Full Name histone deacetylase 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:45191 See related Ensembl:ENSG00000233012 AllianceGenome:HGNC:45191 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
HDAC2, Official Symbol HDAC2provided by HGNC Official Full Name histone deacetylase 2provided by HGNC Primary source HGNC:HGNC:4853 See related Ensembl:ENSG00000196591 MIM:605164; AllianceGenome:HGNC:4853 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD2; RPD3; YAF1; KDAC2 Summary This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] Expression Ubiquitous expression in testis (RPKM 14.8), endometrium (RPKM 10.6) and 25 other tissues See more Orthologs mouse all
HDAC2-AS2, Official Symbol HDAC2-AS2provided by HGNC Official Full Name HDAC2 and HS3ST5 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:43590 See related Ensembl:ENSG00000228624 AllianceGenome:HGNC:43590 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 1.4), brain (RPKM 0.4) and 16 other tissues See more
HDAC3, Official Symbol HDAC3provided by HGNC Official Full Name histone deacetylase 3provided by HGNC Primary source HGNC:HGNC:4854 See related Ensembl:ENSG00000171720 MIM:605166; AllianceGenome:HGNC:4854 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD3; RPD3; KDAC3; RPD3-2 Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 21.1), adrenal (RPKM 20.9) and 25 other tissues See more Orthologs mouse all
HDAC4, Official Symbol HDAC4provided by HGNC Official Full Name histone deacetylase 4provided by HGNC Primary source HGNC:HGNC:14063 See related Ensembl:ENSG00000068024 MIM:605314; AllianceGenome:HGNC:14063 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; NEDCHF; NEDCHID Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 1.6) and 24 other tissues See more Orthologs mouse all
HDAC4-AS1, Official Symbol HDAC4-AS1provided by HGNC Official Full Name HDAC4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54064 See related Ensembl:ENSG00000222020 AllianceGenome:HGNC:54064 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in fat (RPKM 4.7), testis (RPKM 3.5) and 9 other tissues See more
HDAC5, Official Symbol HDAC5provided by HGNC Official Full Name histone deacetylase 5provided by HGNC Primary source HGNC:HGNC:14068 See related Ensembl:ENSG00000108840 MIM:605315; AllianceGenome:HGNC:14068 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD5; NY-CO-9 Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 14.0), ovary (RPKM 13.4) and 25 other tissues See more Orthologs mouse all
HDAC6, Official Symbol HDAC6provided by HGNC Official Full Name histone deacetylase 6provided by HGNC Primary source HGNC:HGNC:14064 See related Ensembl:ENSG00000094631 MIM:300272; AllianceGenome:HGNC:14064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD6; JM21; CPBHM; PPP1R90 Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 18.6), testis (RPKM 15.9) and 25 other tissues See more Orthologs mouse all
HDAC7, Official Symbol HDAC7provided by HGNC Official Full Name histone deacetylase 7provided by HGNC Primary source HGNC:HGNC:14067 See related Ensembl:ENSG00000061273 MIM:606542; AllianceGenome:HGNC:14067 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD7; HD7A; HDAC7A Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 18.9), spleen (RPKM 18.4) and 25 other tissues See more Orthologs mouse all
HDAC8, Official Symbol HDAC8provided by HGNC Official Full Name histone deacetylase 8provided by HGNC Primary source HGNC:HGNC:13315 See related Ensembl:ENSG00000147099 MIM:300269; AllianceGenome:HGNC:13315 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD8; WTS; RPD3; CDA07; CDLS5; KDAC8; MRXS6; HDACL1 Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in adrenal (RPKM 3.9), thyroid (RPKM 3.1) and 25 other tissues See more Orthologs mouse all
HDAC9, Official Symbol HDAC9provided by HGNC Official Full Name histone deacetylase 9provided by HGNC Primary source HGNC:HGNC:14065 See related Ensembl:ENSG00000048052 MIM:606543; AllianceGenome:HGNC:14065 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; ARCND4; HDAC7B; HDAC9B; HDAC9FL Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 2.1), brain (RPKM 2.0) and 24 other tissues See more Orthologs mouse all
HDC, Official Symbol HDCprovided by HGNC Official Full Name histidine decarboxylaseprovided by HGNC Primary source HGNC:HGNC:4855 See related Ensembl:ENSG00000140287 MIM:142704; AllianceGenome:HGNC:4855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010] Expression Broad expression in gall bladder (RPKM 9.0), stomach (RPKM 6.4) and 14 other tissues See more Orthologs mouse all