psui3905/ncbi_genes_summary huggingface dataset:
FBXW5, Official Symbol FBXW5provided by HGNC Official Full Name F-box and WD repeat domain containing 5provided by HGNC Primary source HGNC:HGNC:13613 See related Ensembl:ENSG00000159069 MIM:609072; AllianceGenome:HGNC:13613 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Fbw5 Summary This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 77.8), colon (RPKM 28.1) and 25 other tissues See more Orthologs mouse all
FBXW7, Official Symbol FBXW7provided by HGNC Official Full Name F-box and WD repeat domain containing 7provided by HGNC Primary source HGNC:HGNC:16712 See related Ensembl:ENSG00000109670 MIM:606278; AllianceGenome:HGNC:16712 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; DEDHIL; FBXO30; SEL-10 Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] Expression Broad expression in skin (RPKM 23.3), brain (RPKM 19.1) and 24 other tissues See more Orthologs mouse all
FBXW7-AS1, Official Symbol FBXW7-AS1provided by HGNC Official Full Name FBXW7 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:52397 See related Ensembl:ENSG00000270751 AllianceGenome:HGNC:52397 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEAR; DEspR Summary Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: The ncRNA locus type is based on analysis of genome sequence data and RNA-seq samples. This gene has protein-coding potential in some circumstances (PMID:17446437, PMID:27301377), possibly through use of an ADAR1 RNA-editing mechanism (PMID:33853558). [13 Dec 2016] Note: Be aware that the expression data shown for FBXW7-AS1 is from non-stranded files and not distinguished from that of FBXW7. [08 Aug 2023] Expression Broad expression in brain (RPKM 11.8), skin (RPKM 11.5) and 23 other tissues See more
FBXW8, Official Symbol FBXW8provided by HGNC Official Full Name F-box and WD repeat domain containing 8provided by HGNC Primary source HGNC:HGNC:13597 See related Ensembl:ENSG00000174989 MIM:609073; AllianceGenome:HGNC:13597 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBW6; FBW8; FBX29; FBXW6; FBXO29 Summary This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues See more Orthologs mouse all
FBXW9, Official Symbol FBXW9provided by HGNC Official Full Name F-box and WD repeat domain containing 9provided by HGNC Primary source HGNC:HGNC:28136 See related Ensembl:ENSG00000132004 MIM:609074; AllianceGenome:HGNC:28136 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Fbw9; MEC-15 Summary Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] Expression Broad expression in testis (RPKM 5.8), kidney (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
FCAMR, Official Symbol FCAMRprovided by HGNC Official Full Name Fc alpha and mu receptorprovided by HGNC Primary source HGNC:HGNC:24692 See related Ensembl:ENSG00000162897 MIM:605484; AllianceGenome:HGNC:24692 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD351; FCA/MR; FKSG87; Fcalpha/muR Summary Predicted to enable IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to be involved in adaptive immune response. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 16.8), lymph node (RPKM 10.8) and 4 other tissues See more Orthologs mouse all
FCAR, Official Symbol FCARprovided by HGNC Official Full Name Fc alpha receptorprovided by HGNC Primary source HGNC:HGNC:3608 See related Ensembl:ENSG00000186431 MIM:147045; AllianceGenome:HGNC:3608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD89; FcalphaR; FcalphaRI; CTB-61M7.2 Summary This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward bone marrow (RPKM 95.4) See more Orthologs all
FCER1A, Official Symbol FCER1Aprovided by HGNC Official Full Name Fc epsilon receptor Iaprovided by HGNC Primary source HGNC:HGNC:3609 See related Ensembl:ENSG00000179639 MIM:147140; AllianceGenome:HGNC:3609 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCE1A; FcERI; FCERIA Summary The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011] Expression Broad expression in skin (RPKM 12.7), esophagus (RPKM 10.4) and 20 other tissues See more Orthologs mouse all
FCER1G, Official Symbol FCER1Gprovided by HGNC Official Full Name Fc epsilon receptor Igprovided by HGNC Primary source HGNC:HGNC:3611 See related Ensembl:ENSG00000158869 MIM:147139; AllianceGenome:HGNC:3611 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCRG Summary The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 140.4), spleen (RPKM 128.5) and 19 other tissues See more Orthologs mouse all
FCER2, Official Symbol FCER2provided by HGNC Official Full Name Fc epsilon receptor IIprovided by HGNC Primary source HGNC:HGNC:3612 See related Ensembl:ENSG00000104921 MIM:151445; AllianceGenome:HGNC:3612 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD23; FCE2; CD23A; IGEBF; CLEC4J; FCErII; BLAST-2 Summary The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] Expression Biased expression in spleen (RPKM 20.9), lymph node (RPKM 16.3) and 4 other tissues See more Orthologs mouse all
FCF1, Official Symbol FCF1provided by HGNC Official Full Name FCF1 rRNA-processing proteinprovided by HGNC Primary source HGNC:HGNC:20220 See related Ensembl:ENSG00000119616 AllianceGenome:HGNC:20220 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Bka; UTP24; CGI-35; C14orf111 Summary Enables RNA binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 6.5), colon (RPKM 5.1) and 25 other tissues See more Orthologs mouse all
FCF1P10, Official Symbol FCF1P10provided by HGNC Official Full Name FCF1 pseudogene 10provided by HGNC Primary source HGNC:HGNC:44622 See related Ensembl:ENSG00000218490 AllianceGenome:HGNC:44622 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FCF1P3, Official Symbol FCF1P3provided by HGNC Official Full Name FCF1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:44615 See related Ensembl:ENSG00000239997 AllianceGenome:HGNC:44615 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FCF1P4, Official Symbol FCF1P4provided by HGNC Official Full Name FCF1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:44616 See related Ensembl:ENSG00000226112 AllianceGenome:HGNC:44616 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FCF1P5, Official Symbol FCF1P5provided by HGNC Official Full Name FCF1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:44617 See related Ensembl:ENSG00000220392 AllianceGenome:HGNC:44617 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FCF1P8, Official Symbol FCF1P8provided by HGNC Official Full Name FCF1 pseudogene 8provided by HGNC Primary source HGNC:HGNC:44620 See related AllianceGenome:HGNC:44620 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FCF1P9, Official Symbol FCF1P9provided by HGNC Official Full Name FCF1 pseudogene 9provided by HGNC Primary source HGNC:HGNC:44621 See related Ensembl:ENSG00000231478 AllianceGenome:HGNC:44621 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FCGBP, Official Symbol FCGBPprovided by HGNC Official Full Name Fc gamma binding proteinprovided by HGNC Primary source HGNC:HGNC:13572 See related Ensembl:ENSG00000275395 MIM:617553; AllianceGenome:HGNC:13572 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FC(GAMMA)BP Summary Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Annotation category: suggests misassembly Annotation category: partial on reference assembly Expression Biased expression in colon (RPKM 352.9), thyroid (RPKM 129.4) and 4 other tissues See more Orthologs mouse all
FCGR1A, Official Symbol FCGR1Aprovided by HGNC Official Full Name Fc gamma receptor Iaprovided by HGNC Primary source HGNC:HGNC:3613 See related Ensembl:ENSG00000150337 MIM:146760; AllianceGenome:HGNC:3613 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD64; FCG1; FCRI; CD64A; FCGR1; IGFR1; FcgammaRI Summary This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 19.0), placenta (RPKM 13.4) and 10 other tissues See more Orthologs mouse all
FCGR1CP, Official Symbol FCGR1CPprovided by HGNC Official Full Name Fc gamma receptor Ic, pseudogeneprovided by HGNC Primary source HGNC:HGNC:3615 See related Ensembl:ENSG00000265531 MIM:601503; AllianceGenome:HGNC:3615 Gene type pseudo RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD64c; FCRIC; IGFR1; IGFRC; FCGR1C Summary The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be a pseudogene of Fc-gamma-receptor 1A. [provided by RefSeq, Apr 2009] Expression Biased expression in appendix (RPKM 19.1), placenta (RPKM 14.5) and 11 other tissues See more
FCGR2A, Official Symbol FCGR2Aprovided by HGNC Official Full Name Fc gamma receptor IIaprovided by HGNC Primary source HGNC:HGNC:3616 See related Ensembl:ENSG00000143226 MIM:146790; AllianceGenome:HGNC:3616 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; FcgammaRIIa Summary This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] Expression Broad expression in appendix (RPKM 39.7), placenta (RPKM 36.5) and 21 other tissues See more Orthologs all
FCGR2B, Official Symbol FCGR2Bprovided by HGNC Official Full Name Fc gamma receptor IIbprovided by HGNC Primary source HGNC:HGNC:3618 See related Ensembl:ENSG00000072694 MIM:604590; AllianceGenome:HGNC:3618 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb Summary The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Expression Biased expression in placenta (RPKM 92.9), appendix (RPKM 9.6) and 6 other tissues See more Orthologs all
FCGR3A, Official Symbol FCGR3Aprovided by HGNC Official Full Name Fc gamma receptor IIIaprovided by HGNC Primary source HGNC:HGNC:3619 See related Ensembl:ENSG00000203747 MIM:146740; AllianceGenome:HGNC:3619 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; CD16-II; FCGRIII; FCRIIIA; FcGRIIIA Summary This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Biased expression in spleen (RPKM 154.1), lung (RPKM 70.6) and 10 other tissues See more Orthologs all
FCGR3B, Official Symbol FCGR3Bprovided by HGNC Official Full Name Fc gamma receptor IIIbprovided by HGNC Primary source HGNC:HGNC:3620 See related Ensembl:ENSG00000162747 MIM:610665; AllianceGenome:HGNC:3620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD16; FCG3; CD16A; CD16b; FCGR3; CD16-I; FCGR3A; FCR-10; FCRIII; FCRIIIb Summary The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012] Expression Biased expression in spleen (RPKM 53.3), appendix (RPKM 50.9) and 7 other tissues See more Orthologs all
FCGRT, Official Symbol FCGRTprovided by HGNC Official Full Name Fc gamma receptor and transporterprovided by HGNC Primary source HGNC:HGNC:3621 See related Ensembl:ENSG00000104870 MIM:601437; AllianceGenome:HGNC:3621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCRN; FcgammaRn; alpha-chain Summary This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] Expression Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues See more Orthologs mouse all
FCHO1, Official Symbol FCHO1provided by HGNC Official Full Name FCH and mu domain containing endocytic adaptor 1provided by HGNC Primary source HGNC:HGNC:29002 See related Ensembl:ENSG00000130475 MIM:613437; AllianceGenome:HGNC:29002 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD76 Summary Enables AP-2 adaptor complex binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in cytosol; nucleoplasm; and plasma membrane. Is active in clathrin-coated pit. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 7.7), spleen (RPKM 6.3) and 14 other tissues See more Orthologs mouse all
FCHO2, Official Symbol FCHO2provided by HGNC Official Full Name FCH and mu domain containing endocytic adaptor 2provided by HGNC Primary source HGNC:HGNC:25180 See related Ensembl:ENSG00000157107 MIM:613438; AllianceGenome:HGNC:25180 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables identical protein binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 12.4), thyroid (RPKM 12.1) and 25 other tissues See more Orthologs mouse all
FCHSD1, Official Symbol FCHSD1provided by HGNC Official Full Name FCH and double SH3 domains 1provided by HGNC Primary source HGNC:HGNC:25463 See related Ensembl:ENSG00000197948 MIM:617555; AllianceGenome:HGNC:25463 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NWK2 Summary Predicted to enable lipid binding activity. Predicted to be involved in neuromuscular synaptic transmission and positive regulation of actin filament polymerization. Predicted to be located in cell projection and perikaryon. Predicted to be active in neuromuscular junction and recycling endosome. Predicted to colocalize with cuticular plate. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 9.3), lymph node (RPKM 8.7) and 24 other tissues See more Orthologs mouse all
FCHSD2, Official Symbol FCHSD2provided by HGNC Official Full Name FCH and double SH3 domains 2provided by HGNC Primary source HGNC:HGNC:29114 See related Ensembl:ENSG00000137478 MIM:617556; AllianceGenome:HGNC:29114 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NWK; NWK1; SH3MD3 Summary Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in plasma membrane. Colocalizes with clathrin-coated pit. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 18.6), lymph node (RPKM 17.3) and 25 other tissues See more Orthologs mouse all
FCMR, Official Symbol FCMRprovided by HGNC Official Full Name Fc mu receptorprovided by HGNC Primary source HGNC:HGNC:14315 See related Ensembl:ENSG00000162894 MIM:606015; AllianceGenome:HGNC:14315 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOSO; FAIM3; FcmuR Summary Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010] Expression Biased expression in lymph node (RPKM 59.4), spleen (RPKM 52.0) and 6 other tissues See more Orthologs mouse all
FCN1, Official Symbol FCN1provided by HGNC Official Full Name ficolin 1provided by HGNC Primary source HGNC:HGNC:3623 See related Ensembl:ENSG00000085265 MIM:601252; AllianceGenome:HGNC:3623 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCNM Summary The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 318.5), appendix (RPKM 117.5) and 3 other tissues See more Orthologs mouse all
FCN2, Official Symbol FCN2provided by HGNC Official Full Name ficolin 2provided by HGNC Primary source HGNC:HGNC:3624 See related Ensembl:ENSG00000160339 MIM:601624; AllianceGenome:HGNC:3624 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P35; FCNL; EBP-37; ficolin-2 Summary The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 10.3), adrenal (RPKM 1.6) and 2 other tissues See more Orthologs all
FCN3, Official Symbol FCN3provided by HGNC Official Full Name ficolin 3provided by HGNC Primary source HGNC:HGNC:3625 See related Ensembl:ENSG00000142748 MIM:604973; AllianceGenome:HGNC:3625 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCNH; HAKA1 Summary Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 93.2), liver (RPKM 47.7) and 3 other tissues See more Orthologs all
FCRL1, Official Symbol FCRL1provided by HGNC Official Full Name Fc receptor like 1provided by HGNC Primary source HGNC:HGNC:18509 See related Ensembl:ENSG00000163534 MIM:606508; AllianceGenome:HGNC:18509 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCRH1; IFGP1; IRTA5; CD307a Summary This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] Expression Biased expression in lymph node (RPKM 18.4), spleen (RPKM 14.4) and 3 other tissues See more Orthologs all
FCRL2, Official Symbol FCRL2provided by HGNC Official Full Name Fc receptor like 2provided by HGNC Primary source HGNC:HGNC:14875 See related Ensembl:ENSG00000132704 MIM:606509; AllianceGenome:HGNC:14875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C Summary This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009] Expression Biased expression in lymph node (RPKM 14.2), spleen (RPKM 13.1) and 7 other tissues See more Orthologs all
FCRL3, Official Symbol FCRL3provided by HGNC Official Full Name Fc receptor like 3provided by HGNC Primary source HGNC:HGNC:18506 See related Ensembl:ENSG00000160856 MIM:606510; AllianceGenome:HGNC:18506 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAIA; FCRH3; IFGP3; IRTA3; SPAP2; CD307c Summary This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Biased expression in lymph node (RPKM 31.5), spleen (RPKM 20.4) and 2 other tissues See more Orthologs all
FCRL4, Official Symbol FCRL4provided by HGNC Official Full Name Fc receptor like 4provided by HGNC Primary source HGNC:HGNC:18507 See related Ensembl:ENSG00000163518 MIM:605876; AllianceGenome:HGNC:18507 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCRH4; IGFP2; IRTA1; CD307d Summary This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009] Expression Biased expression in lymph node (RPKM 2.4), appendix (RPKM 2.3) and 5 other tissues See more Orthologs all
FCRL5, Official Symbol FCRL5provided by HGNC Official Full Name Fc receptor like 5provided by HGNC Primary source HGNC:HGNC:18508 See related Ensembl:ENSG00000143297 MIM:605877; AllianceGenome:HGNC:18508 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820 Summary This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010] Expression Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues See more Orthologs all
FCRL6, Official Symbol FCRL6provided by HGNC Official Full Name Fc receptor like 6provided by HGNC Primary source HGNC:HGNC:31910 See related Ensembl:ENSG00000181036 MIM:613562; AllianceGenome:HGNC:31910 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FcRH6 Summary Enables MHC class II protein binding activity and protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 6.7), lung (RPKM 2.6) and 14 other tissues See more Orthologs mouse all
FCRLA, Official Symbol FCRLAprovided by HGNC Official Full Name Fc receptor like Aprovided by HGNC Primary source HGNC:HGNC:18504 See related Ensembl:ENSG00000132185 MIM:606891; AllianceGenome:HGNC:18504 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2 Summary This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011] Expression Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues See more Orthologs mouse all
FCRLB, Official Symbol FCRLBprovided by HGNC Official Full Name Fc receptor like Bprovided by HGNC Primary source HGNC:HGNC:26431 See related Ensembl:ENSG00000162746 MIM:609251; AllianceGenome:HGNC:26431 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FcRY; FCRL2; FCRLY; FREB2; FCRLM2; FREB-2 Summary FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008] Expression Broad expression in kidney (RPKM 1.2), appendix (RPKM 0.8) and 23 other tissues See more Orthologs mouse all
FCSK, Official Symbol FCSKprovided by HGNC Official Full Name fucose kinaseprovided by HGNC Primary source HGNC:HGNC:29500 See related Ensembl:ENSG00000157353 MIM:608675; AllianceGenome:HGNC:29500 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUK; CDGF2; 1110046B12Rik Summary The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 3.1), kidney (RPKM 2.8) and 25 other tissues See more Orthologs mouse all
FDCSP, Official Symbol FDCSPprovided by HGNC Official Full Name follicular dendritic cell secreted proteinprovided by HGNC Primary source HGNC:HGNC:19215 See related Ensembl:ENSG00000181617 MIM:607241; AllianceGenome:HGNC:19215 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C4orf7; FDC-SP Summary This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011] Expression Biased expression in salivary gland (RPKM 447.2), lymph node (RPKM 235.7) and 1 other tissue See more Orthologs mouse all
FDFT1, Official Symbol FDFT1provided by HGNC Official Full Name farnesyl-diphosphate farnesyltransferase 1provided by HGNC Primary source HGNC:HGNC:3629 See related Ensembl:ENSG00000079459 MIM:184420; AllianceGenome:HGNC:3629 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SS; SQS; DGPT; ERG9; SQSD Summary This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 32.6), colon (RPKM 26.2) and 25 other tissues See more Orthologs mouse all
FDPS, Official Symbol FDPSprovided by HGNC Official Full Name farnesyl diphosphate synthaseprovided by HGNC Primary source HGNC:HGNC:3631 See related Ensembl:ENSG00000160752 MIM:134629; AllianceGenome:HGNC:3631 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPS; FPPS; POROK9 Summary This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008] Expression Ubiquitous expression in liver (RPKM 72.6), duodenum (RPKM 62.1) and 25 other tissues See more Orthologs mouse all
FDPSP1, Official Symbol FDPSP1provided by HGNC Official Full Name farnesyl diphosphate synthase pseudogene 1provided by HGNC Primary source HGNC:HGNC:3632 See related Ensembl:ENSG00000225462 AllianceGenome:HGNC:3632 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPSL1; CHR39A; FDPSL1
FDPSP2, Official Symbol FDPSP2provided by HGNC Official Full Name farnesyl diphosphate synthase pseudogene 2provided by HGNC Primary source HGNC:HGNC:3633 See related AllianceGenome:HGNC:3633 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPSL2; FDPSL2; FDPSL2A Annotation information Note: The FDPSP2 nomenclature was previously associated with GeneID:392063, which was determined to be redundant with FDPSP7 (GeneID:441261), and annotated on the wrong strand on the NCBI assembly (Annotation Release 104). HUGO Gene Nomenclature Committee has FDPSP2 symbol associated with GeneID:619190 on chromosome 7 at a different location and strand. To connect location with nomenclature, FDPSP2 nomenclature was moved to GeneID:619190. [17 Jun 2014]
FDPSP3, Official Symbol FDPSP3provided by HGNC Official Full Name farnesyl diphosphate synthase pseudogene 3provided by HGNC Primary source HGNC:HGNC:3634 See related Ensembl:ENSG00000258872 AllianceGenome:HGNC:3634 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPSL3; FDPSL3
FDPSP4, Official Symbol FDPSP4provided by HGNC Official Full Name farnesyl diphosphate synthase pseudogene 4provided by HGNC Primary source HGNC:HGNC:3635 See related Ensembl:ENSG00000254793 AllianceGenome:HGNC:3635 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPSL4; CHR39B; FDPSL4
FDPSP5, Official Symbol FDPSP5provided by HGNC Official Full Name farnesyl diphosphate synthase pseudogene 5provided by HGNC Primary source HGNC:HGNC:3636 See related Ensembl:ENSG00000215035 AllianceGenome:HGNC:3636 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPSL5; CHR39C; FDPSL5