psui3905/ncbi_genes_summary huggingface dataset:
ADGRL3, Official Symbol ADGRL3provided by HGNC Official Full Name adhesion G protein-coupled receptor L3provided by HGNC Primary source HGNC:HGNC:20974 See related Ensembl:ENSG00000150471 MIM:616417; AllianceGenome:HGNC:20974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL3; LEC3; CIRL3; LPHN3 Summary This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 7.2), adrenal (RPKM 1.9) and 13 other tissues See more Orthologs mouse all
ADGRL3-AS1, Official Symbol ADGRL3-AS1provided by HGNC Official Full Name ADGRL3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50604 See related AllianceGenome:HGNC:50604 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPHN3-AS1 Expression Broad expression in brain (RPKM 22.6), adrenal (RPKM 16.9) and 17 other tissues See more
ADGRL4, Official Symbol ADGRL4provided by HGNC Official Full Name adhesion G protein-coupled receptor L4provided by HGNC Primary source HGNC:HGNC:20822 See related Ensembl:ENSG00000162618 MIM:616419; AllianceGenome:HGNC:20822 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ETL; ELTD1; KPG_003 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be integral component of plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 38.7), spleen (RPKM 20.4) and 20 other tissues See more Orthologs mouse all
ADGRV1, Official Symbol ADGRV1provided by HGNC Official Full Name adhesion G protein-coupled receptor V1provided by HGNC Primary source HGNC:HGNC:17416 See related Ensembl:ENSG00000164199 MIM:602851; AllianceGenome:HGNC:17416 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FEB4; GPR98; MASS1; USH2B; USH2C; VLGR1; VLGR1b Summary This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 8.5), brain (RPKM 6.0) and 6 other tissues See more Orthologs mouse all
ADH1A, Official Symbol ADH1Aprovided by HGNC Official Full Name alcohol dehydrogenase 1A (class I), alpha polypeptideprovided by HGNC Primary source HGNC:HGNC:249 See related Ensembl:ENSG00000187758 MIM:103700; AllianceGenome:HGNC:249 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH1 Summary This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010] Expression Biased expression in liver (RPKM 735.3) and fat (RPKM 36.3) See more
ADH1B, Official Symbol ADH1Bprovided by HGNC Official Full Name alcohol dehydrogenase 1B (class I), beta polypeptideprovided by HGNC Primary source HGNC:HGNC:250 See related Ensembl:ENSG00000196616 MIM:103720; AllianceGenome:HGNC:250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH2; HEL-S-117 Summary The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Expression Biased expression in liver (RPKM 1714.7), fat (RPKM 1144.5) and 3 other tissues See more Orthologs all
ADH1C, Official Symbol ADH1Cprovided by HGNC Official Full Name alcohol dehydrogenase 1C (class I), gamma polypeptideprovided by HGNC Primary source HGNC:HGNC:251 See related Ensembl:ENSG00000248144 MIM:103730; AllianceGenome:HGNC:251 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH3 Summary This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019] Expression Biased expression in liver (RPKM 388.0), duodenum (RPKM 230.6) and 5 other tissues See more Orthologs mouse all
ADH4, Official Symbol ADH4provided by HGNC Official Full Name alcohol dehydrogenase 4 (class II), pi polypeptideprovided by HGNC Primary source HGNC:HGNC:252 See related Ensembl:ENSG00000198099 MIM:103740; AllianceGenome:HGNC:252 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH-2; HEL-S-4 Summary This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 940.8) See more Orthologs mouse all
ADH5, Official Symbol ADH5provided by HGNC Official Full Name alcohol dehydrogenase 5 (class III), chi polypeptideprovided by HGNC Primary source HGNC:HGNC:253 See related Ensembl:ENSG00000197894 MIM:103710; AllianceGenome:HGNC:253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FDH; ADHX; ADH-3; AMEDS; BMFS7; FALDH; GSNOR; GSH-FDH; HEL-S-60p Summary This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in endometrium (RPKM 69.1), kidney (RPKM 68.7) and 25 other tissues See more Orthologs mouse all
ADH5P2, Official Symbol ADH5P2provided by HGNC Official Full Name ADH5 pseudogene 2provided by HGNC Primary source HGNC:HGNC:22976 See related Ensembl:ENSG00000232676 AllianceGenome:HGNC:22976 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ADH5P3, Official Symbol ADH5P3provided by HGNC Official Full Name ADH5 pseudogene 3provided by HGNC Primary source HGNC:HGNC:22991 See related Ensembl:ENSG00000223694 AllianceGenome:HGNC:22991 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ADH5P5, Official Symbol ADH5P5provided by HGNC Official Full Name ADH5 pseudogene 5provided by HGNC Primary source HGNC:HGNC:54523 See related Ensembl:ENSG00000234865 AllianceGenome:HGNC:54523 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ADH6, Official Symbol ADH6provided by HGNC Official Full Name alcohol dehydrogenase 6 (class V)provided by HGNC Primary source HGNC:HGNC:255 See related Ensembl:ENSG00000172955 MIM:103735; AllianceGenome:HGNC:255 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH-5 Summary This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 139.0), duodenum (RPKM 20.7) and 2 other tissues See more Orthologs all
ADH7, Official Symbol ADH7provided by HGNC Official Full Name alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideprovided by HGNC Primary source HGNC:HGNC:256 See related Ensembl:ENSG00000196344 MIM:600086; AllianceGenome:HGNC:256 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADH4 Summary This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Expression Restricted expression toward esophagus (RPKM 95.5) See more Orthologs mouse all
ADHFE1, Official Symbol ADHFE1provided by HGNC Official Full Name alcohol dehydrogenase iron containing 1provided by HGNC Primary source HGNC:HGNC:16354 See related Ensembl:ENSG00000147576 MIM:611083; AllianceGenome:HGNC:16354 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOT; ADH8; HMFT2263 Summary The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in heart (RPKM 16.3), fat (RPKM 15.2) and 25 other tissues See more Orthologs mouse all
ADI1, Official Symbol ADI1provided by HGNC Official Full Name acireductone dioxygenase 1provided by HGNC Primary source HGNC:HGNC:30576 See related Ensembl:ENSG00000182551 MIM:613400; AllianceGenome:HGNC:30576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARD; APL1; ARD'; SIPL; mtnD; Fe-ARD; MTCBP1; Ni-ARD; HMFT1638 Summary This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] Expression Ubiquitous expression in liver (RPKM 66.3), kidney (RPKM 48.9) and 24 other tissues See more Orthologs mouse all
ADI1P3, Official Symbol ADI1P3provided by HGNC Official Full Name acireductone dioxygenase 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:52341 See related Ensembl:ENSG00000258369 AllianceGenome:HGNC:52341 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ADIG, Official Symbol ADIGprovided by HGNC Official Full Name adipogeninprovided by HGNC Primary source HGNC:HGNC:28606 See related Ensembl:ENSG00000182035 MIM:611396; AllianceGenome:HGNC:28606 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMAF1 Summary ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008] Expression Restricted expression toward testis (RPKM 13.2) See more Orthologs mouse all
ADIPOQ, Official Symbol ADIPOQprovided by HGNC Official Full Name adiponectin, C1Q and collagen domain containingprovided by HGNC Primary source HGNC:HGNC:13633 See related Ensembl:ENSG00000181092 MIM:605441; AllianceGenome:HGNC:13633 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1 Summary This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010] Expression Restricted expression toward fat (RPKM 648.8) See more Orthologs mouse all
ADIPOQ-AS1, Official Symbol ADIPOQ-AS1provided by HGNC Official Full Name ADIPOQ antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40648 See related Ensembl:ENSG00000226482 AllianceGenome:HGNC:40648 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward fat (RPKM 397.8) See more
ADIPOR1, Official Symbol ADIPOR1provided by HGNC Official Full Name adiponectin receptor 1provided by HGNC Primary source HGNC:HGNC:24040 See related Ensembl:ENSG00000159346 MIM:607945; AllianceGenome:HGNC:24040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A Summary This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in bone marrow (RPKM 58.7), placenta (RPKM 45.4) and 25 other tissues See more Orthologs mouse all
ADIPOR2, Official Symbol ADIPOR2provided by HGNC Official Full Name adiponectin receptor 2provided by HGNC Primary source HGNC:HGNC:24041 See related Ensembl:ENSG00000006831 MIM:607946; AllianceGenome:HGNC:24041 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAQR2; ACDCR2 Summary The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in fat (RPKM 49.9), adrenal (RPKM 34.9) and 25 other tissues See more Orthologs mouse all
ADIRF, Official Symbol ADIRFprovided by HGNC Official Full Name adipogenesis regulatory factorprovided by HGNC Primary source HGNC:HGNC:24043 See related Ensembl:ENSG00000148671 AllianceGenome:HGNC:24043 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AFRO; APM2; apM-2; C10orf116 Summary APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 830.0), prostate (RPKM 218.1) and 10 other tissues See more Orthologs all
ADIRF-AS1, Official Symbol ADIRF-AS1provided by HGNC Official Full Name ADIRF antisense RNA 1provided by HGNC Primary source HGNC:HGNC:45127 See related AllianceGenome:HGNC:45127 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ADK, Official Symbol ADKprovided by HGNC Official Full Name adenosine kinaseprovided by HGNC Primary source HGNC:HGNC:257 See related Ensembl:ENSG00000156110 MIM:102750; AllianceGenome:HGNC:257 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AK Summary This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in liver (RPKM 10.9), thyroid (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
ADM, Official Symbol ADMprovided by HGNC Official Full Name adrenomedullinprovided by HGNC Primary source HGNC:HGNC:259 See related Ensembl:ENSG00000148926 MIM:103275; AllianceGenome:HGNC:259 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AM; PAMP Summary The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014] Expression Broad expression in placenta (RPKM 66.2), fat (RPKM 27.8) and 18 other tissues See more Orthologs mouse all
ADM2, Official Symbol ADM2provided by HGNC Official Full Name adrenomedullin 2provided by HGNC Primary source HGNC:HGNC:28898 See related Ensembl:ENSG00000128165 MIM:608682; AllianceGenome:HGNC:28898 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AM2; dJ579N16.4 Summary This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015] Expression Biased expression in thyroid (RPKM 8.0), kidney (RPKM 5.1) and 12 other tissues See more Orthologs mouse all
ADM5, Official Symbol ADM5provided by HGNC Official Full Name adrenomedullin 5 (putative)provided by HGNC Primary source HGNC:HGNC:27293 See related Ensembl:ENSG00000224420 AllianceGenome:HGNC:27293 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AM5; C19orf76 Summary Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of heart rate; and regulation of urine volume. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
ADNP, Official Symbol ADNPprovided by HGNC Official Full Name activity dependent neuroprotector homeoboxprovided by HGNC Primary source HGNC:HGNC:15766 See related Ensembl:ENSG00000101126 MIM:611386; AllianceGenome:HGNC:15766 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADNP1; HVDAS; MRD28 Summary Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 11.8), ovary (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
ADNP-AS1, Official Symbol ADNP-AS1provided by HGNC Official Full Name ADNP antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51227 See related Ensembl:ENSG00000259456 AllianceGenome:HGNC:51227 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 9.4), bone marrow (RPKM 2.1) and 21 other tissues See more
ADNP2, Official Symbol ADNP2provided by HGNC Official Full Name ADNP homeobox 2provided by HGNC Primary source HGNC:HGNC:23803 See related Ensembl:ENSG00000101544 MIM:617422; AllianceGenome:HGNC:23803 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF508 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulation of cell growth. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 13.5), testis (RPKM 13.2) and 25 other tissues See more Orthologs mouse all
ADO, Official Symbol ADOprovided by HGNC Official Full Name 2-aminoethanethiol dioxygenaseprovided by HGNC Primary source HGNC:HGNC:23506 See related Ensembl:ENSG00000181915 MIM:611392; AllianceGenome:HGNC:23506 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C10orf22 Summary Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008] Orthologs mouse all
ADORA1, Official Symbol ADORA1provided by HGNC Official Full Name adenosine A1 receptorprovided by HGNC Primary source HGNC:HGNC:262 See related Ensembl:ENSG00000163485 MIM:102775; AllianceGenome:HGNC:262 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDC7 Summary The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 15.5), testis (RPKM 10.4) and 8 other tissues See more Orthologs mouse all
ADORA2A, Official Symbol ADORA2Aprovided by HGNC Official Full Name adenosine A2a receptorprovided by HGNC Primary source HGNC:HGNC:263 See related Ensembl:ENSG00000128271 MIM:102776; AllianceGenome:HGNC:263 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A2aR; RDC8; ADORA2 Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013] Expression Broad expression in bone marrow (RPKM 12.9), lymph node (RPKM 8.9) and 22 other tissues See more Orthologs mouse all
ADORA2A-AS1, Official Symbol ADORA2A-AS1provided by HGNC Official Full Name ADORA2A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:37122 See related Ensembl:ENSG00000178803 AllianceGenome:HGNC:37122 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C22orf45; hLinfRNA1 Annotation information Note: This locus has been reported as a novel protein-coding gene (Knowled and McLysaght, PMID: 19726446). NCBI has noted that there is uncertainty about the correct definition of the full-length transcript and which of the predicted short open reading frames is translated. Therefore, we have elected to represent the locus as non-coding until additional data supporting a specific protein product becomes available. [13 Feb 2013] Expression Biased expression in testis (RPKM 3.7), kidney (RPKM 2.7) and 10 other tissues See more
ADORA2B, Official Symbol ADORA2Bprovided by HGNC Official Full Name adenosine A2b receptorprovided by HGNC Primary source HGNC:HGNC:264 See related Ensembl:ENSG00000170425 MIM:600446; AllianceGenome:HGNC:264 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADORA2 Summary This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues See more Orthologs mouse all
ADORA3, Official Symbol ADORA3provided by HGNC Official Full Name adenosine A3 receptorprovided by HGNC Primary source HGNC:HGNC:268 See related Ensembl:ENSG00000282608 MIM:600445; AllianceGenome:HGNC:268 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A3AR Summary This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014] Expression Broad expression in adrenal (RPKM 4.4), small intestine (RPKM 2.9) and 20 other tissues See more Orthologs all
ADPGK, Official Symbol ADPGKprovided by HGNC Official Full Name ADP dependent glucokinaseprovided by HGNC Primary source HGNC:HGNC:25250 See related Ensembl:ENSG00000159322 MIM:611861; AllianceGenome:HGNC:25250 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADP-GK; 2610017G09Rik Summary ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in bone marrow (RPKM 23.6), appendix (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
ADPGK-AS1, Official Symbol ADPGK-AS1provided by HGNC Official Full Name ADPGK antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44144 See related Ensembl:ENSG00000260898 AllianceGenome:HGNC:44144 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ADPRH, Official Symbol ADPRHprovided by HGNC Official Full Name ADP-ribosylarginine hydrolaseprovided by HGNC Primary source HGNC:HGNC:269 See related Ensembl:ENSG00000144843 MIM:603081; AllianceGenome:HGNC:269 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARH1; hARH1 Summary The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014] Expression Ubiquitous expression in lung (RPKM 7.2), spleen (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
ADPRHL1, Official Symbol ADPRHL1provided by HGNC Official Full Name ADP-ribosylhydrolase like 1provided by HGNC Primary source HGNC:HGNC:21303 See related Ensembl:ENSG00000153531 MIM:610620; AllianceGenome:HGNC:21303 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARH2 Summary ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008] Expression Biased expression in heart (RPKM 98.4) and prostate (RPKM 3.2) See more Orthologs mouse all
ADPRM, Official Symbol ADPRMprovided by HGNC Official Full Name ADP-ribose/CDP-alcohol diphosphatase, manganese dependentprovided by HGNC Primary source HGNC:HGNC:30925 See related Ensembl:ENSG00000170222 AllianceGenome:HGNC:30925 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MDS006; C17orf48; NBLA03831 Summary Predicted to enable 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 8.5), prostate (RPKM 8.3) and 25 other tissues See more Orthologs mouse all
ADPRS, Official Symbol ADPRSprovided by HGNC Official Full Name ADP-ribosylserine hydrolaseprovided by HGNC Primary source HGNC:HGNC:21304 See related Ensembl:ENSG00000116863 MIM:610624; AllianceGenome:HGNC:21304 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARH3; ADPRHL2; CONDSIAS Summary This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009] Expression Ubiquitous expression in testis (RPKM 14.2), lung (RPKM 13.1) and 25 other tissues See more Orthologs mouse all
ADRA1A, Official Symbol ADRA1Aprovided by HGNC Official Full Name adrenoceptor alpha 1Aprovided by HGNC Primary source HGNC:HGNC:277 See related Ensembl:ENSG00000120907 MIM:104221; AllianceGenome:HGNC:277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADRA1C; ADRA1L1; ALPHA1AAR Summary Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues See more Orthologs mouse all
ADRA1B, Official Symbol ADRA1Bprovided by HGNC Official Full Name adrenoceptor alpha 1Bprovided by HGNC Primary source HGNC:HGNC:278 See related Ensembl:ENSG00000170214 MIM:104220; AllianceGenome:HGNC:278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADRA1; ALPHA1BAR Summary Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 2.0), brain (RPKM 1.2) and 10 other tissues See more Orthologs mouse all
ADRA1D, Official Symbol ADRA1Dprovided by HGNC Official Full Name adrenoceptor alpha 1Dprovided by HGNC Primary source HGNC:HGNC:280 See related Ensembl:ENSG00000171873 MIM:104219; AllianceGenome:HGNC:280 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2 Summary Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 2.3), spleen (RPKM 0.8) and 10 other tissues See more Orthologs mouse all
ADRA2A, Official Symbol ADRA2Aprovided by HGNC Official Full Name adrenoceptor alpha 2Aprovided by HGNC Primary source HGNC:HGNC:281 See related Ensembl:ENSG00000150594 MIM:104210; AllianceGenome:HGNC:281 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR Summary Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019] Orthologs mouse all
ADRA2B, Official Symbol ADRA2Bprovided by HGNC Official Full Name adrenoceptor alpha 2Bprovided by HGNC Primary source HGNC:HGNC:282 See related Ensembl:ENSG00000274286 MIM:104260; AllianceGenome:HGNC:282 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR Summary This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014] Orthologs mouse all
ADRA2C, Official Symbol ADRA2Cprovided by HGNC Official Full Name adrenoceptor alpha 2Cprovided by HGNC Primary source HGNC:HGNC:283 See related Ensembl:ENSG00000184160 MIM:104250; AllianceGenome:HGNC:283 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR Summary Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] Orthologs mouse all