psui3905/ncbi_genes_summary huggingface dataset:
CYCSP2, Official Symbol CYCSP2provided by HGNC Official Full Name CYCS pseudogene 2provided by HGNC Primary source HGNC:HGNC:24410 See related Ensembl:ENSG00000259547 AllianceGenome:HGNC:24410 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP37
CYCSP20, Official Symbol CYCSP20provided by HGNC Official Full Name CYCS pseudogene 20provided by HGNC Primary source HGNC:HGNC:24394 See related AllianceGenome:HGNC:24394 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP20
CYCSP22, Official Symbol CYCSP22provided by HGNC Official Full Name CYCS pseudogene 22provided by HGNC Primary source HGNC:HGNC:24396 See related AllianceGenome:HGNC:24396 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP22
CYCSP23, Official Symbol CYCSP23provided by HGNC Official Full Name CYCS pseudogene 23provided by HGNC Primary source HGNC:HGNC:24397 See related Ensembl:ENSG00000253495 AllianceGenome:HGNC:24397 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP23
CYCSP32, Official Symbol CYCSP32provided by HGNC Official Full Name CYCS pseudogene 32provided by HGNC Primary source HGNC:HGNC:24406 See related AllianceGenome:HGNC:24406 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP32
CYCSP40, Official Symbol CYCSP40provided by HGNC Official Full Name CYCS pseudogene 40provided by HGNC Primary source HGNC:HGNC:24414 See related AllianceGenome:HGNC:24414 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC7; HCP40
CYCSP41, Official Symbol CYCSP41provided by HGNC Official Full Name CYCS pseudogene 41provided by HGNC Primary source HGNC:HGNC:2580 See related AllianceGenome:HGNC:2580 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP41; CYC1LP4
CYCSP42, Official Symbol CYCSP42provided by HGNC Official Full Name CYCS pseudogene 42provided by HGNC Primary source HGNC:HGNC:2581 See related Ensembl:ENSG00000224524 AllianceGenome:HGNC:2581 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP42; CYC1LP5
CYCSP43, Official Symbol CYCSP43provided by HGNC Official Full Name CYCS pseudogene 43provided by HGNC Primary source HGNC:HGNC:24417 See related AllianceGenome:HGNC:24417 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP43
CYCSP5, Official Symbol CYCSP5provided by HGNC Official Full Name CYCS pseudogene 5provided by HGNC Primary source HGNC:HGNC:24416 See related Ensembl:ENSG00000227735 AllianceGenome:HGNC:24416 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP5
CYCSP52, Official Symbol CYCSP52provided by HGNC Official Full Name CYCS pseudogene 52provided by HGNC Primary source HGNC:HGNC:24393 See related Ensembl:ENSG00000235700 AllianceGenome:HGNC:24393 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC6; HCP2
CYCSP53, Official Symbol CYCSP53provided by HGNC Official Full Name CYCS pseudogene 53provided by HGNC Primary source HGNC:HGNC:24404 See related Ensembl:ENSG00000234333 AllianceGenome:HGNC:24404 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP3
CYCSP55, Official Symbol CYCSP55provided by HGNC Official Full Name CYCS pseudogene 55provided by HGNC Primary source HGNC:HGNC:21252 See related AllianceGenome:HGNC:21252 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HS11; HCP15; CYCSL1; bA513I15.3
CYCSP7, Official Symbol CYCSP7provided by HGNC Official Full Name CYCS pseudogene 7provided by HGNC Primary source HGNC:HGNC:24422 See related AllianceGenome:HGNC:24422 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP7
CYCTP, Official Symbol CYCTPprovided by HGNC Official Full Name cytochrome c, testis, pseudogeneprovided by HGNC Primary source HGNC:HGNC:24424 See related Ensembl:ENSG00000249909 AllianceGenome:HGNC:24424 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCP9 Summary Predicted to enable heme binding activity. Predicted to act upstream of or within hydrogen peroxide metabolic process and positive regulation of intrinsic apoptotic signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]
CYFIP1, Official Symbol CYFIP1provided by HGNC Official Full Name cytoplasmic FMR1 interacting protein 1provided by HGNC Primary source HGNC:HGNC:13759 See related Ensembl:ENSG00000273749 MIM:606322; AllianceGenome:HGNC:13759 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SHYC; SRA1; SRA-1; P140SRA-1 Summary This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, Mar 2022] Expression Ubiquitous expression in placenta (RPKM 24.8), esophagus (RPKM 20.9) and 25 other tissues See more Orthologs mouse all
CYFIP2, Official Symbol CYFIP2provided by HGNC Official Full Name cytoplasmic FMR1 interacting protein 2provided by HGNC Primary source HGNC:HGNC:13760 See related Ensembl:ENSG00000055163 MIM:606323; AllianceGenome:HGNC:13760 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE65; EIEE65; PIR121 Summary Predicted to enable small GTPase binding activity. Involved in activation of cysteine-type endopeptidase activity; apoptotic process; and cell-cell adhesion. Located in perinuclear region of cytoplasm and synapse. Part of SCAR complex. Implicated in developmental and epileptic encephalopathy 65. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 63.0), brain (RPKM 45.0) and 14 other tissues See more Orthologs mouse all
CYGB, Official Symbol CYGBprovided by HGNC Official Full Name cytoglobinprovided by HGNC Primary source HGNC:HGNC:16505 See related Ensembl:ENSG00000161544 MIM:608759; AllianceGenome:HGNC:16505 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HGB; STAP Summary This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in fat (RPKM 16.5), urinary bladder (RPKM 7.0) and 23 other tissues See more Orthologs mouse all
CYLC1, Official Symbol CYLC1provided by HGNC Official Full Name cylicin 1provided by HGNC Primary source HGNC:HGNC:2582 See related Ensembl:ENSG00000183035 MIM:300768; AllianceGenome:HGNC:2582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYCL1 Summary This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] Expression Restricted expression toward testis (RPKM 13.2) See more Orthologs mouse all
CYLC2, Official Symbol CYLC2provided by HGNC Official Full Name cylicin 2provided by HGNC Primary source HGNC:HGNC:2583 See related Ensembl:ENSG00000155833 MIM:604035; AllianceGenome:HGNC:2583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 24.8) See more Orthologs mouse all
CYLD, Official Symbol CYLDprovided by HGNC Official Full Name CYLD lysine 63 deubiquitinaseprovided by HGNC Primary source HGNC:HGNC:2584 See related Ensembl:ENSG00000083799 MIM:605018; AllianceGenome:HGNC:2584 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2; FTDALS8 Summary This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 13.0), lymph node (RPKM 10.5) and 25 other tissues See more Orthologs mouse all
CYLD-AS1, Official Symbol CYLD-AS1provided by HGNC Official Full Name CYLD antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55352 See related Ensembl:ENSG00000261644 AllianceGenome:HGNC:55352 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in spleen (RPKM 2.0), appendix (RPKM 2.0) and 25 other tissues See more
CYMP, Official Symbol CYMPprovided by HGNC Official Full Name chymosin, pseudogeneprovided by HGNC Primary source HGNC:HGNC:2588 See related Ensembl:ENSG00000240194 MIM:118943; AllianceGenome:HGNC:2588 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
CYMP-AS1, Official Symbol CYMP-AS1provided by HGNC Official Full Name CYMP antisense RNA 1provided by HGNC Primary source HGNC:HGNC:52509 See related Ensembl:ENSG00000235407 AllianceGenome:HGNC:52509 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
CYP11A1, Official Symbol CYP11A1provided by HGNC Official Full Name cytochrome P450 family 11 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2590 See related Ensembl:ENSG00000140459 MIM:118485; AllianceGenome:HGNC:2590 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP11A; CYPXIA1; P450SCC Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 261.9), placenta (RPKM 29.0) and 1 other tissue See more Orthologs mouse all
CYP11B1, Official Symbol CYP11B1provided by HGNC Official Full Name cytochrome P450 family 11 subfamily B member 1provided by HGNC Primary source HGNC:HGNC:2591 See related Ensembl:ENSG00000160882 MIM:610613; AllianceGenome:HGNC:2591 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHI; CPN1; CYP11B; P450C11 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward adrenal (RPKM 1098.5) See more Orthologs all
CYP11B2, Official Symbol CYP11B2provided by HGNC Official Full Name cytochrome P450 family 11 subfamily B member 2provided by HGNC Primary source HGNC:HGNC:2592 See related Ensembl:ENSG00000179142 MIM:124080; AllianceGenome:HGNC:2592 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPN2; ALDOS; CYP11B; CYP11BL; CYPXIB2; P450C18; P-450C18; P450aldo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008] Expression Restricted expression toward adrenal (RPKM 110.5) See more Orthologs mouse all
CYP17A1, Official Symbol CYP17A1provided by HGNC Official Full Name cytochrome P450 family 17 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2593 See related Ensembl:ENSG00000148795 MIM:609300; AllianceGenome:HGNC:2593 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPT7; CYP17; S17AH; P450C17 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008] Expression Restricted expression toward adrenal (RPKM 1959.5) See more Orthologs mouse all
CYP19A1, Official Symbol CYP19A1provided by HGNC Official Full Name cytochrome P450 family 19 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2594 See related Ensembl:ENSG00000137869 MIM:107910; AllianceGenome:HGNC:2594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016] Expression Restricted expression toward placenta (RPKM 83.2) See more Orthologs mouse all
CYP1A1, Official Symbol CYP1A1provided by HGNC Official Full Name cytochrome P450 family 1 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2595 See related Ensembl:ENSG00000140465 MIM:108330; AllianceGenome:HGNC:2595 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX Summary This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016] Expression Biased expression in urinary bladder (RPKM 40.8), liver (RPKM 18.0) and 1 other tissue See more Orthologs mouse all
CYP1A2, Official Symbol CYP1A2provided by HGNC Official Full Name cytochrome P450 family 1 subfamily A member 2provided by HGNC Primary source HGNC:HGNC:2596 See related Ensembl:ENSG00000140505 MIM:124060; AllianceGenome:HGNC:2596 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP12; CYPIA2; P3-450; P450(PA) Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 100.8) See more Orthologs all
CYP1B1, Official Symbol CYP1B1provided by HGNC Official Full Name cytochrome P450 family 1 subfamily B member 1provided by HGNC Primary source HGNC:HGNC:2597 See related Ensembl:ENSG00000138061 MIM:601771; AllianceGenome:HGNC:2597 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP1B; ASGD6; GLC3A; CYPIB1; P4501B1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008] Expression Broad expression in prostate (RPKM 32.6), endometrium (RPKM 26.2) and 19 other tissues See more Orthologs mouse all
CYP1B1-AS1, Official Symbol CYP1B1-AS1provided by HGNC Official Full Name CYP1B1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:28543 See related Ensembl:ENSG00000232973 AllianceGenome:HGNC:28543 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf58 Expression Low expression observed in reference dataset See more
CYP1D1P, Official Symbol CYP1D1Pprovided by HGNC Official Full Name cytochrome P450 family 1 subfamily D member 1, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39968 See related Ensembl:ENSG00000228024 AllianceGenome:HGNC:39968 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP1D1; CYP1A8P
CYP20A1, Official Symbol CYP20A1provided by HGNC Official Full Name cytochrome P450 family 20 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:20576 See related Ensembl:ENSG00000119004 AllianceGenome:HGNC:20576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP-M Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 2.4), kidney (RPKM 1.7) and 25 other tissues See more Orthologs mouse all
CYP21A1P, Official Symbol CYP21A1Pprovided by HGNC Official Full Name cytochrome P450 family 21 subfamily A member 1, pseudogeneprovided by HGNC Primary source HGNC:HGNC:2599 See related Ensembl:ENSG00000290788 AllianceGenome:HGNC:2599 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP21A; CYP21P; P450c21A Expression Biased expression in adrenal (RPKM 198.1) and fat (RPKM 7.0) See more
CYP21A2, Official Symbol CYP21A2provided by HGNC Official Full Name cytochrome P450 family 21 subfamily A member 2provided by HGNC Primary source HGNC:HGNC:2600 See related Ensembl:ENSG00000231852 MIM:613815; AllianceGenome:HGNC:2600 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward adrenal (RPKM 498.8) See more Orthologs mouse all
CYP24A1, Official Symbol CYP24A1provided by HGNC Official Full Name cytochrome P450 family 24 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2602 See related Ensembl:ENSG00000019186 MIM:126065; AllianceGenome:HGNC:2602 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP24; HCAI; CYP24; HCINF1; P450-CC24 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in urinary bladder (RPKM 21.5), endometrium (RPKM 10.7) and 2 other tissues See more Orthologs mouse all
CYP26A1, Official Symbol CYP26A1provided by HGNC Official Full Name cytochrome P450 family 26 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2603 See related Ensembl:ENSG00000095596 MIM:602239; AllianceGenome:HGNC:2603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP26; CYP26; P450RAI; P450RAI1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 15.5) See more Orthologs mouse all
CYP26B1, Official Symbol CYP26B1provided by HGNC Official Full Name cytochrome P450 family 26 subfamily B member 1provided by HGNC Primary source HGNC:HGNC:20581 See related Ensembl:ENSG00000003137 MIM:605207; AllianceGenome:HGNC:20581 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHFCA; CYP26A2; P450RAI2; P450RAI-2 Summary This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] Expression Broad expression in testis (RPKM 9.5), skin (RPKM 9.2) and 21 other tissues See more Orthologs mouse all
CYP26C1, Official Symbol CYP26C1provided by HGNC Official Full Name cytochrome P450 family 26 subfamily C member 1provided by HGNC Primary source HGNC:HGNC:20577 See related Ensembl:ENSG00000187553 MIM:608428; AllianceGenome:HGNC:20577 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FFDD4 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
CYP27A1, Official Symbol CYP27A1provided by HGNC Official Full Name cytochrome P450 family 27 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2605 See related Ensembl:ENSG00000135929 MIM:606530; AllianceGenome:HGNC:2605 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTX; CP27; CYP27 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 101.4), small intestine (RPKM 27.6) and 16 other tissues See more Orthologs mouse all
CYP27B1, Official Symbol CYP27B1provided by HGNC Official Full Name cytochrome P450 family 27 subfamily B member 1provided by HGNC Primary source HGNC:HGNC:2606 See related Ensembl:ENSG00000111012 MIM:609506; AllianceGenome:HGNC:2606 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VDR; CP2B; CYP1; PDDR; VDD1; VDDR; VDDRI; CYP27B; P450c1; CYP1alpha Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 9.5), thyroid (RPKM 4.8) and 4 other tissues See more Orthologs mouse all
CYP27C1, Official Symbol CYP27C1provided by HGNC Official Full Name cytochrome P450 family 27 subfamily C member 1provided by HGNC Primary source HGNC:HGNC:33480 See related Ensembl:ENSG00000186684 AllianceGenome:HGNC:33480 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 1.8), urinary bladder (RPKM 0.5) and 11 other tissues See more Orthologs all
CYP2A13, Official Symbol CYP2A13provided by HGNC Official Full Name cytochrome P450 family 2 subfamily A member 13provided by HGNC Primary source HGNC:HGNC:2608 See related Ensembl:ENSG00000197838 MIM:608055; AllianceGenome:HGNC:2608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPAD; CYP2A; CYPIIA13 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 9.1) See more Orthologs all
CYP2A6, Official Symbol CYP2A6provided by HGNC Official Full Name cytochrome P450 family 2 subfamily A member 6provided by HGNC Primary source HGNC:HGNC:2610 See related Ensembl:ENSG00000255974 MIM:122720; AllianceGenome:HGNC:2610 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPA6; CYP2A; CYP2A3; P450PB; CYPIIA6; P450C2A Summary This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 542.0) See more
CYP2A7, Official Symbol CYP2A7provided by HGNC Official Full Name cytochrome P450 family 2 subfamily A member 7provided by HGNC Primary source HGNC:HGNC:2611 See related Ensembl:ENSG00000198077 MIM:608054; AllianceGenome:HGNC:2611 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPA7; CPAD; CYP2A; CYPIIA7; P450-IIA4 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 27.5) See more Orthologs all
CYP2A7P1, Official Symbol CYP2A7P1provided by HGNC Official Full Name cytochrome P450 family 2 subfamily A member 7 pseudogene 1provided by HGNC Primary source HGNC:HGNC:2612 See related Ensembl:ENSG00000213908 AllianceGenome:HGNC:2612 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP2A7P2; CYP2A7PT; CYP2A18PC; CYP2A18PN
CYP2AB1P, Official Symbol CYP2AB1Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily AB member 1, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39975 See related Ensembl:ENSG00000233441 AllianceGenome:HGNC:39975 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP2AC1P, Official Symbol CYP2AC1Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily AC member 1, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39976 See related Ensembl:ENSG00000216998 AllianceGenome:HGNC:39976 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP2B6, Official Symbol CYP2B6provided by HGNC Official Full Name cytochrome P450 family 2 subfamily B member 6provided by HGNC Primary source HGNC:HGNC:2615 See related Ensembl:ENSG00000197408 MIM:123930; AllianceGenome:HGNC:2615 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6 Summary This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 124.8) See more Orthologs all
CYP2B7P, Official Symbol CYP2B7Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily B member 7, pseudogeneprovided by HGNC Primary source HGNC:HGNC:2616 See related Ensembl:ENSG00000291083 AllianceGenome:HGNC:2616 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP2B; CYP2B7; CYP2B7P1 Expression Biased expression in lung (RPKM 25.4), liver (RPKM 15.7) and 3 other tissues See more
CYP2C18, Official Symbol CYP2C18provided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 18provided by HGNC Primary source HGNC:HGNC:2620 See related Ensembl:ENSG00000108242 MIM:601131; AllianceGenome:HGNC:2620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 50.3), duodenum (RPKM 49.6) and 5 other tissues See more Orthologs all
CYP2C19, Official Symbol CYP2C19provided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 19provided by HGNC Primary source HGNC:HGNC:2621 See related Ensembl:ENSG00000165841 MIM:124020; AllianceGenome:HGNC:2621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 80.1), duodenum (RPKM 37.5) and 3 other tissues See more Orthologs all
CYP2C23P, Official Symbol CYP2C23Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 23, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39970 See related Ensembl:ENSG00000283232 AllianceGenome:HGNC:39970 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP2C62P
CYP2C56P, Official Symbol CYP2C56Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 56, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39971 See related Ensembl:ENSG00000229641 AllianceGenome:HGNC:39971 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP2C58P, Official Symbol CYP2C58Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 58, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39969 See related Ensembl:ENSG00000235199 AllianceGenome:HGNC:39969 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo