psui3905/ncbi_genes_summary huggingface dataset:
DGKB, Official Symbol DGKBprovided by HGNC Official Full Name diacylglycerol kinase betaprovided by HGNC Primary source HGNC:HGNC:2850 See related Ensembl:ENSG00000136267 MIM:604070; AllianceGenome:HGNC:2850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DGK; DAGK2; DGK-BETA Summary Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017] Expression Biased expression in brain (RPKM 7.2), adrenal (RPKM 0.9) and 2 other tissues See more Orthologs mouse all
DGKD, Official Symbol DGKDprovided by HGNC Official Full Name diacylglycerol kinase deltaprovided by HGNC Primary source HGNC:HGNC:2851 See related Ensembl:ENSG00000077044 MIM:601826; AllianceGenome:HGNC:2851 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dgkd-2; DGKdelta; DGK-delta Summary This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in stomach (RPKM 11.9), bone marrow (RPKM 9.9) and 23 other tissues See more Orthologs mouse all
DGKE, Official Symbol DGKEprovided by HGNC Official Full Name diacylglycerol kinase epsilonprovided by HGNC Primary source HGNC:HGNC:2852 See related Ensembl:ENSG00000153933 MIM:601440; AllianceGenome:HGNC:2852 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DGK; AHUS7; DAGK5; DAGK6; NPHS7 Summary Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 3.8), spleen (RPKM 3.2) and 25 other tissues See more Orthologs mouse all
DGKG, Official Symbol DGKGprovided by HGNC Official Full Name diacylglycerol kinase gammaprovided by HGNC Primary source HGNC:HGNC:2853 See related Ensembl:ENSG00000058866 MIM:601854; AllianceGenome:HGNC:2853 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAGK3; DGK-GAMMA Summary This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 8.0), heart (RPKM 3.6) and 15 other tissues See more Orthologs mouse all
DGKH, Official Symbol DGKHprovided by HGNC Official Full Name diacylglycerol kinase etaprovided by HGNC Primary source HGNC:HGNC:2854 See related Ensembl:ENSG00000102780 MIM:604071; AllianceGenome:HGNC:2854 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DGKeta Summary This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in endometrium (RPKM 2.6), placenta (RPKM 1.9) and 24 other tissues See more Orthologs mouse all
DGKI, Official Symbol DGKIprovided by HGNC Official Full Name diacylglycerol kinase iotaprovided by HGNC Primary source HGNC:HGNC:2855 See related Ensembl:ENSG00000157680 MIM:604072; AllianceGenome:HGNC:2855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DGK-IOTA Summary This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008] Expression Biased expression in thyroid (RPKM 5.1), brain (RPKM 1.6) and 1 other tissue See more Orthologs mouse all
DGKK, Official Symbol DGKKprovided by HGNC Official Full Name diacylglycerol kinase kappaprovided by HGNC Primary source HGNC:HGNC:32395 See related Ensembl:ENSG00000274588 MIM:300837; AllianceGenome:HGNC:32395 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011] Expression Biased expression in adrenal (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue See more Orthologs mouse all
DGKQ, Official Symbol DGKQprovided by HGNC Official Full Name diacylglycerol kinase thetaprovided by HGNC Primary source HGNC:HGNC:2856 See related Ensembl:ENSG00000145214 MIM:601207; AllianceGenome:HGNC:2856 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAGK; DAGK4; DAGK7 Summary The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in small intestine (RPKM 9.9), duodenum (RPKM 8.3) and 25 other tissues See more Orthologs mouse all
DGKZ, Official Symbol DGKZprovided by HGNC Official Full Name diacylglycerol kinase zetaprovided by HGNC Primary source HGNC:HGNC:2857 See related Ensembl:ENSG00000149091 MIM:601441; AllianceGenome:HGNC:2857 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAGK5; DAGK6; DGK-ZETA; hDGKzeta Summary The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in brain (RPKM 24.7), bone marrow (RPKM 15.6) and 24 other tissues See more Orthologs mouse all
DGKZP1, Official Symbol DGKZP1provided by HGNC Official Full Name diacylglycerol kinase zeta pseudogene 1provided by HGNC Primary source HGNC:HGNC:39263 See related Ensembl:ENSG00000179611 AllianceGenome:HGNC:39263 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
DGLUCY, Official Symbol DGLUCYprovided by HGNC Official Full Name D-glutamate cyclaseprovided by HGNC Primary source HGNC:HGNC:20498 See related Ensembl:ENSG00000133943 AllianceGenome:HGNC:20498 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C14orf159 Summary Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 27.3), kidney (RPKM 11.9) and 24 other tissues See more Orthologs mouse all
DGUOK, Official Symbol DGUOKprovided by HGNC Official Full Name deoxyguanosine kinaseprovided by HGNC Primary source HGNC:HGNC:2858 See related Ensembl:ENSG00000114956 MIM:601465; AllianceGenome:HGNC:2858 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dGK; NCPH; NCPH1; PEOB4; MTDPS3 Summary In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 20.4), lymph node (RPKM 18.7) and 25 other tissues See more Orthologs mouse all
DGUOK-AS1, Official Symbol DGUOK-AS1provided by HGNC Official Full Name DGUOK antisense RNA 1provided by HGNC Primary source HGNC:HGNC:43441 See related AllianceGenome:HGNC:43441 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in adrenal (RPKM 4.2), colon (RPKM 4.2) and 25 other tissues See more
DHCR24, Official Symbol DHCR24provided by HGNC Official Full Name 24-dehydrocholesterol reductaseprovided by HGNC Primary source HGNC:HGNC:2859 See related Ensembl:ENSG00000116133 MIM:606418; AllianceGenome:HGNC:2859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCE; SELADIN1; Nbla03646; seladin-1 Summary This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008] Expression Biased expression in adrenal (RPKM 515.3), liver (RPKM 200.4) and 12 other tissues See more Orthologs mouse all
DHCR7, Official Symbol DHCR7provided by HGNC Official Full Name 7-dehydrocholesterol reductaseprovided by HGNC Primary source HGNC:HGNC:2860 See related Ensembl:ENSG00000172893 MIM:602858; AllianceGenome:HGNC:2860 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLOS Summary This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009] Expression Broad expression in liver (RPKM 39.9), adrenal (RPKM 35.8) and 24 other tissues See more Orthologs mouse all
DHDDS, Official Symbol DHDDSprovided by HGNC Official Full Name dehydrodolichyl diphosphate synthase subunitprovided by HGNC Primary source HGNC:HGNC:20603 See related Ensembl:ENSG00000117682 MIM:608172; AllianceGenome:HGNC:20603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DS; CIT; CPT; HDS; RP59; hCIT; DEDSM Summary The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in fat (RPKM 22.0), colon (RPKM 11.7) and 24 other tissues See more Orthologs mouse all
DHDH, Official Symbol DHDHprovided by HGNC Official Full Name dihydrodiol dehydrogenaseprovided by HGNC Primary source HGNC:HGNC:17887 See related Ensembl:ENSG00000104808 MIM:606377; AllianceGenome:HGNC:17887 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 2DD; HUM2DD Summary This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 7.4), small intestine (RPKM 4.3) and 5 other tissues See more Orthologs mouse all
DHFR, Official Symbol DHFRprovided by HGNC Official Full Name dihydrofolate reductaseprovided by HGNC Primary source HGNC:HGNC:2861 See related Ensembl:ENSG00000228716 MIM:126060; AllianceGenome:HGNC:2861 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DYR; DHFR1; DHFRP1 Summary Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in fat (RPKM 21.2), lymph node (RPKM 18.2) and 24 other tissues See more Orthologs mouse all
DHFR2, Official Symbol DHFR2provided by HGNC Official Full Name dihydrofolate reductase 2provided by HGNC Primary source HGNC:HGNC:27309 See related Ensembl:ENSG00000178700 MIM:616588; AllianceGenome:HGNC:27309 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DHFRL1; DHFRP4 Summary Enables dihydrofolate reductase activity and mRNA binding activity. Involved in tetrahydrofolate metabolic process and thymidine biosynthetic process. Located in mitochondrial inner membrane and mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 4.0), endometrium (RPKM 4.0) and 25 other tissues See more Orthologs all
DHFRP5, Official Symbol DHFRP5provided by HGNC Official Full Name dihydrofolate reductase pseudogene 5provided by HGNC Primary source HGNC:HGNC:52355 See related AllianceGenome:HGNC:52355 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
DHH, Official Symbol DHHprovided by HGNC Official Full Name desert hedgehog signaling moleculeprovided by HGNC Primary source HGNC:HGNC:2865 See related Ensembl:ENSG00000139549 MIM:605423; AllianceGenome:HGNC:2865 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDMN; GDXYM; HHG-3; SRXY7 Summary This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010] Expression Biased expression in testis (RPKM 5.9) and appendix (RPKM 0.3) See more Orthologs mouse all
DHODH, Official Symbol DHODHprovided by HGNC Official Full Name dihydroorotate dehydrogenase (quinone)provided by HGNC Primary source HGNC:HGNC:2867 See related Ensembl:ENSG00000102967 MIM:126064; AllianceGenome:HGNC:2867 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as URA1; POADS; DHOdehase Summary The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 7.8), kidney (RPKM 1.7) and 24 other tissues See more Orthologs mouse all
DHPS, Official Symbol DHPSprovided by HGNC Official Full Name deoxyhypusine synthaseprovided by HGNC Primary source HGNC:HGNC:2869 See related Ensembl:ENSG00000095059 MIM:600944; AllianceGenome:HGNC:2869 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DS; DHS; MIG13; NEDSSWI Summary This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011] Expression Ubiquitous expression in ovary (RPKM 15.4), brain (RPKM 14.5) and 25 other tissues See more Orthologs mouse all
DHRS1, Official Symbol DHRS1provided by HGNC Official Full Name dehydrogenase/reductase 1provided by HGNC Primary source HGNC:HGNC:16445 See related Ensembl:ENSG00000157379 MIM:610410; AllianceGenome:HGNC:16445 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR19C1 Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in liver (RPKM 39.6), esophagus (RPKM 38.5) and 24 other tissues See more Orthologs mouse all
DHRS11, Official Symbol DHRS11provided by HGNC Official Full Name dehydrogenase/reductase 11provided by HGNC Primary source HGNC:HGNC:28639 See related Ensembl:ENSG00000278535 MIM:616159; AllianceGenome:HGNC:28639 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARPG836; SDR24C1; spDHRS11 Summary Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; and 3-keto sterol reductase activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 115.7), small intestine (RPKM 99.1) and 4 other tissues See more Orthologs mouse all
DHRS12, Official Symbol DHRS12provided by HGNC Official Full Name dehydrogenase/reductase 12provided by HGNC Primary source HGNC:HGNC:25832 See related Ensembl:ENSG00000102796 MIM:616163; AllianceGenome:HGNC:25832 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR40C1 Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in fat (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more Orthologs all
DHRS13, Official Symbol DHRS13provided by HGNC Official Full Name dehydrogenase/reductase 13provided by HGNC Primary source HGNC:HGNC:28326 See related Ensembl:ENSG00000167536 MIM:616157; AllianceGenome:HGNC:28326 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR7C5 Summary Predicted to enable NADP-retinol dehydrogenase activity. Predicted to be involved in retinal metabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 14.4), prostate (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
DHRS2, Official Symbol DHRS2provided by HGNC Official Full Name dehydrogenase/reductase 2provided by HGNC Primary source HGNC:HGNC:18349 See related Ensembl:ENSG00000100867 MIM:615194; AllianceGenome:HGNC:18349 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HEP27; SDR25C1 Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017] Expression Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues See more Orthologs mouse all
DHRS3, Official Symbol DHRS3provided by HGNC Official Full Name dehydrogenase/reductase 3provided by HGNC Primary source HGNC:HGNC:17693 See related Ensembl:ENSG00000162496 MIM:612830; AllianceGenome:HGNC:17693 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR1; RDH17; Rsdr1; DD83.1; SDR16C1; retSDR1; CNALPTC1 Summary Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in endoplasmic reticulum membrane and photoreceptor outer segment membrane. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in liver (RPKM 41.2), fat (RPKM 39.1) and 25 other tissues See more Orthologs mouse all
DHRS4, Official Symbol DHRS4provided by HGNC Official Full Name dehydrogenase/reductase 4provided by HGNC Primary source HGNC:HGNC:16985 See related Ensembl:ENSG00000157326 MIM:611596; AllianceGenome:HGNC:16985 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CR; NRDR; PHCR; PSCD; SDR-SRL; SDR25C1; SDR25C2; SCAD-SRL Summary Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including cellular ketone metabolic process; positive regulation of reactive oxygen species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 98.6), small intestine (RPKM 30.5) and 22 other tissues See more Orthologs all
DHRS4-AS1, Official Symbol DHRS4-AS1provided by HGNC Official Full Name DHRS4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:23175 See related Ensembl:ENSG00000215256 MIM:616925; AllianceGenome:HGNC:23175 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRO1488; AS1DHRS4; C14orf67; DHRS4AS1; C14orf167 Expression Ubiquitous expression in kidney (RPKM 24.8), duodenum (RPKM 10.1) and 24 other tissues See more
DHRS4L2, Official Symbol DHRS4L2provided by HGNC Official Full Name dehydrogenase/reductase 4 like 2provided by HGNC Primary source HGNC:HGNC:19731 See related Ensembl:ENSG00000187630 MIM:615196; AllianceGenome:HGNC:19731 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR25C3 Summary This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010] Expression Broad expression in kidney (RPKM 43.2), small intestine (RPKM 16.8) and 24 other tissues See more Orthologs all
DHRS7, Official Symbol DHRS7provided by HGNC Official Full Name dehydrogenase/reductase 7provided by HGNC Primary source HGNC:HGNC:21524 See related Ensembl:ENSG00000100612 MIM:612833; AllianceGenome:HGNC:21524 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-86; SDR34C1; retDSR4; retSDR4 Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016] Expression Broad expression in prostate (RPKM 116.8), small intestine (RPKM 40.2) and 22 other tissues See more Orthologs mouse all
DHRS7B, Official Symbol DHRS7Bprovided by HGNC Official Full Name dehydrogenase/reductase 7Bprovided by HGNC Primary source HGNC:HGNC:24547 See related Ensembl:ENSG00000109016 MIM:616160; AllianceGenome:HGNC:24547 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-93; SDR32C1 Summary Predicted to enable DNA-binding transcription factor binding activity and transcription corepressor activity. Predicted to be involved in neutrophil differentiation. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 7.1), thyroid (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
DHRS7C, Official Symbol DHRS7Cprovided by HGNC Official Full Name dehydrogenase/reductase 7Cprovided by HGNC Primary source HGNC:HGNC:32423 See related Ensembl:ENSG00000184544 MIM:616161; AllianceGenome:HGNC:32423 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR32C2 Summary Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in extracellular region and longitudinal sarcoplasmic reticulum. Predicted to be active in sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward heart (RPKM 31.7) See more Orthologs mouse all
DHRS9, Official Symbol DHRS9provided by HGNC Official Full Name dehydrogenase/reductase 9provided by HGNC Primary source HGNC:HGNC:16888 See related Ensembl:ENSG00000073737 MIM:612131; AllianceGenome:HGNC:16888 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDHL; RDH15; RDHTBE; SDR9C4; RDH-TBE; RETSDR8; hRoDH-E2; 3ALPHA-HSD; 3-alpha-HSD Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Biased expression in colon (RPKM 23.4), esophagus (RPKM 9.8) and 12 other tissues See more Orthologs mouse all
DHRSX, Official Symbol DHRSXprovided by HGNC Official Full Name dehydrogenase/reductase X-linkedprovided by HGNC Primary source HGNC:HGNC:18399 See related Ensembl:ENSG00000169084 Ensembl:ENSG00000292338 MIM:301034; AllianceGenome:HGNC:18399 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DHRSY; DHRS5X; DHRS5Y; DHRSXY; SDR7C6; CXorf11; SDR46C1 Summary Predicted to enable oxidoreductase activity. Involved in positive regulation of autophagy. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 6.0), liver (RPKM 5.1) and 25 other tissues See more Orthologs mouse all
DHTKD1, Official Symbol DHTKD1provided by HGNC Official Full Name dehydrogenase E1 and transketolase domain containing 1provided by HGNC Primary source HGNC:HGNC:23537 See related Ensembl:ENSG00000181192 MIM:614984; AllianceGenome:HGNC:23537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E1a; AAKAD; CMT2Q; AMOXAD; OADC-E1; OADH-E1 Summary This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013] Expression Broad expression in liver (RPKM 30.3), kidney (RPKM 21.7) and 24 other tissues See more Orthologs mouse all
DHX15, Official Symbol DHX15provided by HGNC Official Full Name DEAH-box helicase 15provided by HGNC Primary source HGNC:HGNC:2738 See related Ensembl:ENSG00000109606 MIM:603403; AllianceGenome:HGNC:2738 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBP1; DDX15; PRP43; PRPF43; hPrp43; PrPp43p Summary The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 42.0), lymph node (RPKM 36.6) and 25 other tissues See more Orthologs mouse all
DHX16, Official Symbol DHX16provided by HGNC Official Full Name DEAH-box helicase 16provided by HGNC Primary source HGNC:HGNC:2739 See related Ensembl:ENSG00000204560 MIM:603405; AllianceGenome:HGNC:2739 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBP2; PRP8; Prp2; DDX16; NMOAS; PRPF2; PRO2014 Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018] Expression Ubiquitous expression in testis (RPKM 17.0), spleen (RPKM 9.0) and 25 other tissues See more Orthologs mouse all
DHX29, Official Symbol DHX29provided by HGNC Official Full Name DExH-box helicase 29provided by HGNC Primary source HGNC:HGNC:15815 See related Ensembl:ENSG00000067248 MIM:612720; AllianceGenome:HGNC:15815 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX29 Summary This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in thyroid (RPKM 12.7), prostate (RPKM 10.7) and 25 other tissues See more Orthologs mouse all
DHX30, Official Symbol DHX30provided by HGNC Official Full Name DExH-box helicase 30provided by HGNC Primary source HGNC:HGNC:16716 See related Ensembl:ENSG00000132153 MIM:616423; AllianceGenome:HGNC:16716 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX30; RETCOR; NEDMIAL Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013] Expression Broad expression in testis (RPKM 30.7), brain (RPKM 11.0) and 25 other tissues See more Orthologs mouse all
DHX32, Official Symbol DHX32provided by HGNC Official Full Name DEAH-box helicase 32 (putative)provided by HGNC Primary source HGNC:HGNC:16717 See related Ensembl:ENSG00000089876 MIM:607960; AllianceGenome:HGNC:16717 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX32; DHLP1 Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.2), colon (RPKM 13.8) and 25 other tissues See more Orthologs mouse all
DHX33, Official Symbol DHX33provided by HGNC Official Full Name DEAH-box helicase 33provided by HGNC Primary source HGNC:HGNC:16718 See related Ensembl:ENSG00000005100 MIM:614405; AllianceGenome:HGNC:16718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX33 Summary This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in brain (RPKM 5.2), appendix (RPKM 3.8) and 25 other tissues See more Orthologs mouse all
DHX33-DT, Official Symbol DHX33-DTprovided by HGNC Official Full Name DHX33 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:52937 See related Ensembl:ENSG00000262099 AllianceGenome:HGNC:52937 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
DHX34, Official Symbol DHX34provided by HGNC Official Full Name DExH-box helicase 34provided by HGNC Primary source HGNC:HGNC:16719 See related Ensembl:ENSG00000134815 MIM:615475; AllianceGenome:HGNC:16719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRH1; DDX34 Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 9.0), bone marrow (RPKM 4.3) and 25 other tissues See more Orthologs mouse all
DHX35, Official Symbol DHX35provided by HGNC Official Full Name DEAH-box helicase 35provided by HGNC Primary source HGNC:HGNC:15861 See related Ensembl:ENSG00000101452 AllianceGenome:HGNC:15861 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DDX35; C20orf15; KAIA0875 Summary DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010] Expression Ubiquitous expression in testis (RPKM 6.1), endometrium (RPKM 6.0) and 25 other tissues See more Orthologs mouse all