psui3905/ncbi_genes_summary huggingface dataset:
FMO1, Official Symbol FMO1provided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 1provided by HGNC Primary source HGNC:HGNC:3769 See related Ensembl:ENSG00000010932 MIM:136130; AllianceGenome:HGNC:3769 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Expression Biased expression in kidney (RPKM 54.7), small intestine (RPKM 8.2) and 1 other tissue See more Orthologs mouse all
FMO11P, Official Symbol FMO11Pprovided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 11, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32212 See related Ensembl:ENSG00000232148 AllianceGenome:HGNC:32212 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FMO2, Official Symbol FMO2provided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 2provided by HGNC Primary source HGNC:HGNC:3770 See related Ensembl:ENSG00000094963 MIM:603955; AllianceGenome:HGNC:3770 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FMO1B1 Summary This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] Expression Biased expression in fat (RPKM 59.7), lung (RPKM 58.7) and 8 other tissues See more Orthologs mouse all
FMO3, Official Symbol FMO3provided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 3provided by HGNC Primary source HGNC:HGNC:3771 See related Ensembl:ENSG00000007933 MIM:136132; AllianceGenome:HGNC:3771 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMAU; FMOII; dJ127D3.1 Summary Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016] Expression Biased expression in liver (RPKM 241.9) and adrenal (RPKM 8.6) See more Orthologs mouse all
FMO4, Official Symbol FMO4provided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 4provided by HGNC Primary source HGNC:HGNC:3772 See related Ensembl:ENSG00000076258 MIM:136131; AllianceGenome:HGNC:3772 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FMO2 Summary Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in kidney (RPKM 11.6), liver (RPKM 9.8) and 23 other tissues See more Orthologs mouse all
FMO5, Official Symbol FMO5provided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 5provided by HGNC Primary source HGNC:HGNC:3773 See related Ensembl:ENSG00000131781 MIM:603957; AllianceGenome:HGNC:3773 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hBVMO1 Summary Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] Expression Biased expression in liver (RPKM 65.3), small intestine (RPKM 17.2) and 8 other tissues See more Orthologs mouse all
FMO6P, Official Symbol FMO6Pprovided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 6, pseudogeneprovided by HGNC Primary source HGNC:HGNC:24024 See related Ensembl:ENSG00000117507 AllianceGenome:HGNC:24024 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FMO6 Summary Predicted to enable monooxygenase activity. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in salivary gland (RPKM 4.7) and stomach (RPKM 0.8) See more
FMO7P, Official Symbol FMO7Pprovided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 7, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32208 See related Ensembl:ENSG00000230231 AllianceGenome:HGNC:32208 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FMO8P, Official Symbol FMO8Pprovided by HGNC Official Full Name flavin containing dimethylaniline monoxygenase 8, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32209 See related Ensembl:ENSG00000238087 AllianceGenome:HGNC:32209 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FMOD, Official Symbol FMODprovided by HGNC Official Full Name fibromodulinprovided by HGNC Primary source HGNC:HGNC:3774 See related Ensembl:ENSG00000122176 MIM:600245; AllianceGenome:HGNC:3774 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FM; SLRR2E Summary Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Expression Broad expression in gall bladder (RPKM 78.8), fat (RPKM 77.4) and 22 other tissues See more Orthologs mouse all
FMR1, Official Symbol FMR1provided by HGNC Official Full Name fragile X messenger ribonucleoprotein 1provided by HGNC Primary source HGNC:HGNC:3775 See related Ensembl:ENSG00000102081 MIM:309550; AllianceGenome:HGNC:3775 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POF; FMRP; POF1; FRAXA Summary The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010] Expression Ubiquitous expression in thyroid (RPKM 16.8), brain (RPKM 15.9) and 25 other tissues See more Orthologs mouse all
FMR1-AS1, Official Symbol FMR1-AS1provided by HGNC Official Full Name FMR1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39081 See related Ensembl:ENSG00000268066 MIM:300805; AllianceGenome:HGNC:39081 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FMR4; FMR5; ASFMR1; FMR1AS; FMR1-AS Expression Low expression observed in reference dataset See more Orthologs mouse all
FMR1NB, Official Symbol FMR1NBprovided by HGNC Official Full Name FMR1 neighborprovided by HGNC Primary source HGNC:HGNC:26372 See related Ensembl:ENSG00000176988 AllianceGenome:HGNC:26372 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT37; NYSAR35; NY-SAR-35 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 27.9) See more Orthologs mouse all
FN1, Official Symbol FN1provided by HGNC Official Full Name fibronectin 1provided by HGNC Primary source HGNC:HGNC:3778 See related Ensembl:ENSG00000115414 MIM:135600; AllianceGenome:HGNC:3778 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF Summary This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016] Expression Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues See more Orthologs mouse all
FN3K, Official Symbol FN3Kprovided by HGNC Official Full Name fructosamine 3 kinaseprovided by HGNC Primary source HGNC:HGNC:24822 See related Ensembl:ENSG00000167363 MIM:608425; AllianceGenome:HGNC:24822 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012] Expression Broad expression in kidney (RPKM 47.7), brain (RPKM 22.0) and 20 other tissues See more Orthologs mouse all
FN3KRP, Official Symbol FN3KRPprovided by HGNC Official Full Name fructosamine 3 kinase related proteinprovided by HGNC Primary source HGNC:HGNC:25700 See related Ensembl:ENSG00000141560 MIM:611683; AllianceGenome:HGNC:25700 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FN3KL Summary A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in brain (RPKM 19.2), fat (RPKM 14.3) and 25 other tissues See more Orthologs mouse all
FNBP1, Official Symbol FNBP1provided by HGNC Official Full Name formin binding protein 1provided by HGNC Primary source HGNC:HGNC:17069 See related Ensembl:ENSG00000187239 MIM:606191; AllianceGenome:HGNC:17069 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBP17 Summary The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 19.9), spleen (RPKM 17.6) and 24 other tissues See more Orthologs mouse all
FNBP1L, Official Symbol FNBP1Lprovided by HGNC Official Full Name formin binding protein 1 likeprovided by HGNC Primary source HGNC:HGNC:20851 See related Ensembl:ENSG00000137942 MIM:608848; AllianceGenome:HGNC:20851 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOCA1; C1orf39 Summary The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 14.8), kidney (RPKM 13.9) and 24 other tissues See more Orthologs mouse all
FNBP1P1, Official Symbol FNBP1P1provided by HGNC Official Full Name formin binding protein 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44528 See related AllianceGenome:HGNC:44528 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FNBP4, Official Symbol FNBP4provided by HGNC Official Full Name formin binding protein 4provided by HGNC Primary source HGNC:HGNC:19752 See related Ensembl:ENSG00000109920 MIM:615265; AllianceGenome:HGNC:19752 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBP30 Summary This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in spleen (RPKM 13.0), lymph node (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
FNDC1, Official Symbol FNDC1provided by HGNC Official Full Name fibronectin type III domain containing 1provided by HGNC Primary source HGNC:HGNC:21184 See related Ensembl:ENSG00000164694 MIM:609991; AllianceGenome:HGNC:21184 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGS8; FNDC2; MEL4B3; bA243O10.1; dJ322A24.1 Summary Predicted to act upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in gall bladder (RPKM 10.5), thyroid (RPKM 9.5) and 12 other tissues See more Orthologs mouse all
FNDC1-IT1, Official Symbol FNDC1-IT1provided by HGNC Official Full Name FNDC1 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41460 See related Ensembl:ENSG00000235086 AllianceGenome:HGNC:41460 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FNDC10, Official Symbol FNDC10provided by HGNC Official Full Name fibronectin type III domain containing 10provided by HGNC Primary source HGNC:HGNC:42951 See related Ensembl:ENSG00000228594 AllianceGenome:HGNC:42951 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1orf233 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
FNDC11, Official Symbol FNDC11provided by HGNC Official Full Name fibronectin type III domain containing 11provided by HGNC Primary source HGNC:HGNC:28764 See related Ensembl:ENSG00000125531 AllianceGenome:HGNC:28764 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C20orf195 Expression Restricted expression toward testis (RPKM 14.6) See more Orthologs mouse all
FNDC3A, Official Symbol FNDC3Aprovided by HGNC Official Full Name fibronectin type III domain containing 3Aprovided by HGNC Primary source HGNC:HGNC:20296 See related Ensembl:ENSG00000102531 MIM:615794; AllianceGenome:HGNC:20296 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HUGO; FNDC3; bA203I16.1; bA203I16.5 Summary Enables RNA binding activity. Predicted to act upstream of or within several processes, including Sertoli cell development; fertilization; and spermatid development. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 26.8), adrenal (RPKM 18.9) and 25 other tissues See more Orthologs mouse all
FNDC3B, Official Symbol FNDC3Bprovided by HGNC Official Full Name fibronectin type III domain containing 3Bprovided by HGNC Primary source HGNC:HGNC:24670 See related Ensembl:ENSG00000075420 MIM:611909; AllianceGenome:HGNC:24670 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAD104; PRO4979; YVTM2421 Summary Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 11.7) and 25 other tissues See more Orthologs mouse all
FNDC4, Official Symbol FNDC4provided by HGNC Official Full Name fibronectin type III domain containing 4provided by HGNC Primary source HGNC:HGNC:20239 See related Ensembl:ENSG00000115226 MIM:611905; AllianceGenome:HGNC:20239 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRCP1 Summary Involved in response to transforming growth factor beta. Predicted to be located in endoplasmic reticulum and extracellular space. Predicted to be active in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in adrenal (RPKM 35.7), brain (RPKM 13.1) and 11 other tissues See more Orthologs mouse all
FNDC5, Official Symbol FNDC5provided by HGNC Official Full Name fibronectin type III domain containing 5provided by HGNC Primary source HGNC:HGNC:20240 See related Ensembl:ENSG00000160097 MIM:611906; AllianceGenome:HGNC:20240 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRCP2; irisin Summary This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Expression Biased expression in heart (RPKM 13.5), liver (RPKM 8.6) and 10 other tissues See more Orthologs mouse all
FNDC7, Official Symbol FNDC7provided by HGNC Official Full Name fibronectin type III domain containing 7provided by HGNC Primary source HGNC:HGNC:26668 See related Ensembl:ENSG00000143107 AllianceGenome:HGNC:26668 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
FNDC8, Official Symbol FNDC8provided by HGNC Official Full Name fibronectin type III domain containing 8provided by HGNC Primary source HGNC:HGNC:25286 See related Ensembl:ENSG00000073598 AllianceGenome:HGNC:25286 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 39.7) and brain (RPKM 1.6) See more Orthologs mouse all
FNDC9, Official Symbol FNDC9provided by HGNC Official Full Name fibronectin type III domain containing 9provided by HGNC Primary source HGNC:HGNC:33547 See related Ensembl:ENSG00000172568 AllianceGenome:HGNC:33547 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C5orf40 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 8.0) and adrenal (RPKM 2.8) See more Orthologs mouse all
FNIP1, Official Symbol FNIP1provided by HGNC Official Full Name folliculin interacting protein 1provided by HGNC Primary source HGNC:HGNC:29418 See related Ensembl:ENSG00000217128 MIM:610594; AllianceGenome:HGNC:29418 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD93 Summary This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in testis (RPKM 9.3), thyroid (RPKM 7.7) and 25 other tissues See more Orthologs mouse all
FNIP2, Official Symbol FNIP2provided by HGNC Official Full Name folliculin interacting protein 2provided by HGNC Primary source HGNC:HGNC:29280 See related Ensembl:ENSG00000052795 MIM:612768; AllianceGenome:HGNC:29280 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FNIPL; MAPO1 Summary This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
FNTA, Official Symbol FNTAprovided by HGNC Official Full Name farnesyltransferase, CAAX box, alphaprovided by HGNC Primary source HGNC:HGNC:3782 See related Ensembl:ENSG00000168522 MIM:134635; AllianceGenome:HGNC:3782 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPTA; PTAR2; PGGT1A Summary Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010] Expression Ubiquitous expression in fat (RPKM 32.7), placenta (RPKM 27.4) and 25 other tissues See more Orthologs mouse all
FNTB, Official Symbol FNTBprovided by HGNC Official Full Name farnesyltransferase, CAAX box, betaprovided by HGNC Primary source HGNC:HGNC:3785 See related Ensembl:ENSG00000257365 MIM:134636; AllianceGenome:HGNC:3785 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPTB Summary Enables zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation. Part of microtubule associated complex and protein farnesyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 9.3), brain (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
FOCAD, Official Symbol FOCADprovided by HGNC Official Full Name focadhesinprovided by HGNC Primary source HGNC:HGNC:23377 See related Ensembl:ENSG00000188352 MIM:614606; AllianceGenome:HGNC:23377 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCOLIV; KIAA1797 Summary Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 11.9), adrenal (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
FOCAD-AS1, Official Symbol FOCAD-AS1provided by HGNC Official Full Name FOCAD antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49789 See related Ensembl:ENSG00000227071 AllianceGenome:HGNC:49789 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FOLH1, Official Symbol FOLH1provided by HGNC Official Full Name folate hydrolase 1provided by HGNC Primary source HGNC:HGNC:3788 See related Ensembl:ENSG00000086205 MIM:600934; AllianceGenome:HGNC:3788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1 Summary This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010] Expression Biased expression in duodenum (RPKM 94.9), prostate (RPKM 43.3) and 6 other tissues See more Orthologs mouse all
FOLH1B, Official Symbol FOLH1Bprovided by HGNC Official Full Name folate hydrolase 1B (pseudogene)provided by HGNC Primary source HGNC:HGNC:13636 See related MIM:609020; AllianceGenome:HGNC:13636 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSM; FOLH2; FOLHP; PSMAL; PSMA-LIKE Summary Enables metallocarboxypeptidase activity. Involved in C-terminal protein deglutamylation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 38.8), prostate (RPKM 20.3) and 6 other tissues See more Orthologs all
FOLR1, Official Symbol FOLR1provided by HGNC Official Full Name folate receptor alphaprovided by HGNC Primary source HGNC:HGNC:3791 See related Ensembl:ENSG00000110195 MIM:136430; AllianceGenome:HGNC:3791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBP; FOLR; NCFTD; FRalpha Summary The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] Expression Biased expression in lung (RPKM 83.5), kidney (RPKM 59.8) and 4 other tissues See more Orthologs mouse all
FOLR1P1, Official Symbol FOLR1P1provided by HGNC Official Full Name folate receptor 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:3792 See related AllianceGenome:HGNC:3792 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KB-1; FOLR1P
FOLR2, Official Symbol FOLR2provided by HGNC Official Full Name folate receptor betaprovided by HGNC Primary source HGNC:HGNC:3793 See related Ensembl:ENSG00000165457 MIM:136425; AllianceGenome:HGNC:3793 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1 Summary The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 67.9), gall bladder (RPKM 33.0) and 20 other tissues See more Orthologs mouse all
FOLR3, Official Symbol FOLR3provided by HGNC Official Full Name folate receptor gammaprovided by HGNC Primary source HGNC:HGNC:3795 See related Ensembl:ENSG00000110203 MIM:602469; AllianceGenome:HGNC:3795 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FR-G; FRgamma; FR-gamma; gamma-hFR Summary This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in bone marrow (RPKM 27.0), appendix (RPKM 4.9) and 3 other tissues See more Orthologs all
FOS, Official Symbol FOSprovided by HGNC Official Full Name Fos proto-oncogene, AP-1 transcription factor subunitprovided by HGNC Primary source HGNC:HGNC:3796 See related Ensembl:ENSG00000170345 MIM:164810; AllianceGenome:HGNC:3796 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p55; AP-1; C-FOS Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 802.2), gall bladder (RPKM 632.2) and 23 other tissues See more Orthologs mouse all
FOSB, Official Symbol FOSBprovided by HGNC Official Full Name FosB proto-oncogene, AP-1 transcription factor subunitprovided by HGNC Primary source HGNC:HGNC:3797 See related Ensembl:ENSG00000125740 MIM:164772; AllianceGenome:HGNC:3797 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AP-1; G0S3; GOS3; GOSB Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 202.0), bone marrow (RPKM 136.2) and 23 other tissues See more Orthologs mouse all
FOSL1, Official Symbol FOSL1provided by HGNC Official Full Name FOS like 1, AP-1 transcription factor subunitprovided by HGNC Primary source HGNC:HGNC:13718 See related Ensembl:ENSG00000175592 MIM:136515; AllianceGenome:HGNC:13718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRA; FRA1; fra-1 Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] Expression Biased expression in gall bladder (RPKM 16.7), urinary bladder (RPKM 10.2) and 13 other tissues See more Orthologs mouse all
FOSL1P1, Official Symbol FOSL1P1provided by HGNC Official Full Name FOSL1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44055 See related AllianceGenome:HGNC:44055 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FOSL2, Official Symbol FOSL2provided by HGNC Official Full Name FOS like 2, AP-1 transcription factor subunitprovided by HGNC Primary source HGNC:HGNC:3798 See related Ensembl:ENSG00000075426 MIM:601575; AllianceGenome:HGNC:3798 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRA2 Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in adrenal (RPKM 58.8), bone marrow (RPKM 50.0) and 23 other tissues See more Orthologs mouse all
FOXA1, Official Symbol FOXA1provided by HGNC Official Full Name forkhead box A1provided by HGNC Primary source HGNC:HGNC:5021 See related Ensembl:ENSG00000129514 MIM:602294; AllianceGenome:HGNC:5021 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNF3A; TCF3A Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 46.5), urinary bladder (RPKM 12.0) and 6 other tissues See more Orthologs mouse all
FOXA2, Official Symbol FOXA2provided by HGNC Official Full Name forkhead box A2provided by HGNC Primary source HGNC:HGNC:5022 See related Ensembl:ENSG00000125798 MIM:600288; AllianceGenome:HGNC:5022 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNF3B; TCF3B; HNF-3-beta Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] Expression Biased expression in stomach (RPKM 15.2), lung (RPKM 9.0) and 8 other tissues See more Orthologs mouse all
FOXA3, Official Symbol FOXA3provided by HGNC Official Full Name forkhead box A3provided by HGNC Primary source HGNC:HGNC:5023 See related Ensembl:ENSG00000170608 MIM:602295; AllianceGenome:HGNC:5023 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHH3; HNF3G; TCF3G Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 21.0), stomach (RPKM 17.8) and 6 other tissues See more Orthologs mouse all