psui3905/ncbi_genes_summary huggingface dataset:
OTULIN, Official Symbol OTULINprovided by HGNC Official Full Name OTU deubiquitinase with linear linkage specificityprovided by HGNC Primary source HGNC:HGNC:25118 See related Ensembl:ENSG00000154124 MIM:615712; AllianceGenome:HGNC:25118 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GUM; AIPDS; IMD107; FAM105B Summary This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in bone marrow (RPKM 5.9), skin (RPKM 4.5) and 25 other tissues See more Orthologs mouse all
OTULIN-DT, Official Symbol OTULIN-DTprovided by HGNC Official Full Name OTULIN divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55368 See related Ensembl:ENSG00000261360 AllianceGenome:HGNC:55368 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OTULINL, Official Symbol OTULINLprovided by HGNC Official Full Name OTU deubiquitinase with linear linkage specificity likeprovided by HGNC Primary source HGNC:HGNC:25629 See related Ensembl:ENSG00000145569 AllianceGenome:HGNC:25629 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NET20; FAM105A Summary Located in cytoplasm. Is extrinsic component of endoplasmic reticulum membrane. Colocalizes with nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 12.7), colon (RPKM 9.2) and 21 other tissues See more Orthologs mouse all
OTX1, Official Symbol OTX1provided by HGNC Official Full Name orthodenticle homeobox 1provided by HGNC Primary source HGNC:HGNC:8521 See related Ensembl:ENSG00000115507 MIM:600036; AllianceGenome:HGNC:8521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Biased expression in skin (RPKM 2.2), prostate (RPKM 0.7) and 5 other tissues See more Orthologs mouse all
OTX2, Official Symbol OTX2provided by HGNC Official Full Name orthodenticle homeobox 2provided by HGNC Primary source HGNC:HGNC:8522 See related Ensembl:ENSG00000165588 MIM:600037; AllianceGenome:HGNC:8522 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPHD6; MCOPS5 Summary This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012] Expression Low expression observed in reference dataset See more Orthologs mouse all
OTX2-AS1, Official Symbol OTX2-AS1provided by HGNC Official Full Name OTX2 antisense RNA 1 (head to head)provided by HGNC Primary source HGNC:HGNC:43906 See related Ensembl:ENSG00000248550 AllianceGenome:HGNC:43906 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTX2OS1 Expression Low expression observed in reference dataset See more
OTX2P1, Official Symbol OTX2P1provided by HGNC Official Full Name OTX2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:33281 See related AllianceGenome:HGNC:33281 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTX2P
OTX2P2, Official Symbol OTX2P2provided by HGNC Official Full Name OTX2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:54560 See related Ensembl:ENSG00000227134 AllianceGenome:HGNC:54560 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OVAAL, Official Symbol OVAALprovided by HGNC Official Full Name ovarian adenocarcinoma amplified long non-coding RNAprovided by HGNC Primary source HGNC:HGNC:49422 See related Ensembl:ENSG00000236719 AllianceGenome:HGNC:49422 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OVAL; RMEL2; LINC01131 Expression Restricted expression toward heart (RPKM 1.1) See more
OVCA2, Official Symbol OVCA2provided by HGNC Official Full Name OVCA2 serine hydrolase domain containingprovided by HGNC Primary source HGNC:HGNC:24203 See related Ensembl:ENSG00000262664 MIM:607896; AllianceGenome:HGNC:24203 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in response to retinoic acid. Located in cytoplasm. Biomarker of ovarian cancer. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 23.0), gall bladder (RPKM 21.3) and 25 other tissues See more Orthologs mouse all
OVCH1, Official Symbol OVCH1provided by HGNC Official Full Name ovochymase 1provided by HGNC Primary source HGNC:HGNC:23080 See related Ensembl:ENSG00000187950 AllianceGenome:HGNC:23080 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OVCH Summary Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
OVCH1-AS1, Official Symbol OVCH1-AS1provided by HGNC Official Full Name OVCH1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44484 See related Ensembl:ENSG00000257599 AllianceGenome:HGNC:44484 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 3.3), appendix (RPKM 0.3) and 6 other tissues See more
OVCH2, Official Symbol OVCH2provided by HGNC Official Full Name ovochymase 2provided by HGNC Primary source HGNC:HGNC:29970 See related Ensembl:ENSG00000183378 MIM:618962; AllianceGenome:HGNC:29970 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OVTN Summary Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 2.1), kidney (RPKM 1.0) and 5 other tissues See more Orthologs mouse all
OVGP1, Official Symbol OVGP1provided by HGNC Official Full Name oviductal glycoprotein 1provided by HGNC Primary source HGNC:HGNC:8524 See related Ensembl:ENSG00000085465 MIM:603578; AllianceGenome:HGNC:8524 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EGP; OGP; MUC9; CHIT5 Summary This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 11.4), testis (RPKM 3.0) and 16 other tissues See more Orthologs mouse all
OVOL1, Official Symbol OVOL1provided by HGNC Official Full Name ovo like transcriptional repressor 1provided by HGNC Primary source HGNC:HGNC:8525 See related Ensembl:ENSG00000172818 MIM:602313; AllianceGenome:HGNC:8525 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOVO1 Summary This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011] Expression Biased expression in esophagus (RPKM 10.0), testis (RPKM 9.1) and 9 other tissues See more Orthologs mouse all
OVOL1-AS1, Official Symbol OVOL1-AS1provided by HGNC Official Full Name OVOL1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49319 See related Ensembl:ENSG00000255120 AllianceGenome:HGNC:49319 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 6.9), skin (RPKM 2.5) and 6 other tissues See more
OVOL2, Official Symbol OVOL2provided by HGNC Official Full Name ovo like zinc finger 2provided by HGNC Primary source HGNC:HGNC:15804 See related Ensembl:ENSG00000125850 MIM:616441; AllianceGenome:HGNC:15804 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHED; CHED1; CHED2; PPCD1; ZNF339; EUROIMAGE566589 Summary This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016] Expression Broad expression in stomach (RPKM 6.1), colon (RPKM 3.5) and 15 other tissues See more Orthologs mouse all
OVOL3, Official Symbol OVOL3provided by HGNC Official Full Name ovo like zinc finger 3provided by HGNC Primary source HGNC:HGNC:14186 See related Ensembl:ENSG00000105261 MIM:616442; AllianceGenome:HGNC:14186 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOVO3 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
OVOS2, Gene symbol OVOS2 Gene description alpha-2-macroglobulin like 1 pseudogene See related Ensembl:ENSG00000177359 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 5.2), small intestine (RPKM 0.8) and 3 other tissues See more Orthologs all
OXA1L, Official Symbol OXA1Lprovided by HGNC Official Full Name OXA1L mitochondrial inner membrane proteinprovided by HGNC Primary source HGNC:HGNC:8526 See related Ensembl:ENSG00000155463 MIM:601066; AllianceGenome:HGNC:8526 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OXA1; OXA1L1 Summary This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in heart (RPKM 54.4), duodenum (RPKM 53.5) and 25 other tissues See more Orthologs mouse all
OXCT1, Official Symbol OXCT1provided by HGNC Official Full Name 3-oxoacid CoA-transferase 1provided by HGNC Primary source HGNC:HGNC:8527 See related Ensembl:ENSG00000083720 MIM:601424; AllianceGenome:HGNC:8527 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OXCT; SCOT Summary This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008] Expression Broad expression in heart (RPKM 90.1), brain (RPKM 37.8) and 19 other tissues See more Orthologs mouse all
OXCT1-AS1, Official Symbol OXCT1-AS1provided by HGNC Official Full Name OXCT1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40423 See related Ensembl:ENSG00000248668 AllianceGenome:HGNC:40423 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SARRAH Expression Broad expression in heart (RPKM 4.2), brain (RPKM 3.5) and 21 other tissues See more
OXCT2, Official Symbol OXCT2provided by HGNC Official Full Name 3-oxoacid CoA-transferase 2provided by HGNC Primary source HGNC:HGNC:18606 See related Ensembl:ENSG00000198754 MIM:610289; AllianceGenome:HGNC:18606 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCOTT; FKSG25 Summary The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016] Orthologs mouse all
OXCT2P1, Official Symbol OXCT2P1provided by HGNC Official Full Name 3-oxoacid CoA-transferase 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:21627 See related Ensembl:ENSG00000237624 AllianceGenome:HGNC:21627 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OXCT2P
OXER1, Official Symbol OXER1provided by HGNC Official Full Name oxoeicosanoid receptor 1provided by HGNC Primary source HGNC:HGNC:24884 See related Ensembl:ENSG00000162881 MIM:620064; AllianceGenome:HGNC:24884 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPCR; GPR170; TG1019 Summary Enables G protein-coupled receptor activity and icosanoid binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
OXGR1, Official Symbol OXGR1provided by HGNC Official Full Name oxoglutarate receptor 1provided by HGNC Primary source HGNC:HGNC:4531 See related Ensembl:ENSG00000165621 MIM:606922; AllianceGenome:HGNC:4531 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as aKGR; CAON2; GPR80; GPR99; P2Y15; P2RY15 Summary This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] Expression Broad expression in kidney (RPKM 1.0), colon (RPKM 0.6) and 14 other tissues See more Orthologs mouse all
OXLD1, Official Symbol OXLD1provided by HGNC Official Full Name oxidoreductase like domain containing 1provided by HGNC Primary source HGNC:HGNC:27901 See related Ensembl:ENSG00000204237 AllianceGenome:HGNC:27901 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C17orf90 Expression Ubiquitous expression in spleen (RPKM 8.6), lymph node (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
OXNAD1, Official Symbol OXNAD1provided by HGNC Official Full Name oxidoreductase NAD binding domain containing 1provided by HGNC Primary source HGNC:HGNC:25128 See related Ensembl:ENSG00000154814 AllianceGenome:HGNC:25128 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable oxidoreductase activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 2.7), appendix (RPKM 1.8) and 24 other tissues See more Orthologs mouse all
OXR1, Official Symbol OXR1provided by HGNC Official Full Name oxidation resistance 1provided by HGNC Primary source HGNC:HGNC:15822 See related Ensembl:ENSG00000164830 MIM:605609; AllianceGenome:HGNC:15822 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLDC3; CHEGDD; Nbla00307 Summary Predicted to enable oxidoreductase activity. Predicted to be involved in response to oxidative stress. Predicted to act upstream of or within several processes, including adult walking behavior; negative regulation of neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Predicted to be located in mitochondrion and nucleolus. Predicted to be active in nucleus. Implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 30.5), testis (RPKM 21.8) and 24 other tissues See more Orthologs mouse all
OXSM, Official Symbol OXSMprovided by HGNC Official Full Name 3-oxoacyl-ACP synthase, mitochondrialprovided by HGNC Primary source HGNC:HGNC:26063 See related Ensembl:ENSG00000151093 MIM:610324; AllianceGenome:HGNC:26063 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KS; CEM1; KASI; FASN2D Summary This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009] Expression Ubiquitous expression in testis (RPKM 3.3), thyroid (RPKM 1.6) and 25 other tissues See more Orthologs mouse all
OXSR1, Official Symbol OXSR1provided by HGNC Official Full Name oxidative stress responsive kinase 1provided by HGNC Primary source HGNC:HGNC:8508 See related Ensembl:ENSG00000172939 MIM:604046; AllianceGenome:HGNC:8508 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSR1 Summary The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008] Annotation information Note: OSR1 (Gene ID: 130497) and OXSR1 (Gene ID: 9943) share the OSR1 symbol/alias in common. OSR1 is a widely used alternative name for oxidative stress responsive 1 (OXSR1). [29 Jun 2018] Expression Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues See more Orthologs mouse all
OXT, Official Symbol OXTprovided by HGNC Official Full Name oxytocin/neurophysin I prepropeptideprovided by HGNC Primary source HGNC:HGNC:8528 See related Ensembl:ENSG00000101405 MIM:167050; AllianceGenome:HGNC:8528 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OT; OT-NPI; OXT-NPI Summary This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013] Expression Biased expression in liver (RPKM 1.6), kidney (RPKM 0.7) and 5 other tissues See more Orthologs mouse all
OXTR, Official Symbol OXTRprovided by HGNC Official Full Name oxytocin receptorprovided by HGNC Primary source HGNC:HGNC:8529 See related Ensembl:ENSG00000180914 MIM:167055; AllianceGenome:HGNC:8529 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTR; OT-R Summary The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008] Expression Broad expression in ovary (RPKM 1.0), endometrium (RPKM 1.0) and 16 other tissues See more Orthologs mouse all
P2RX1, Official Symbol P2RX1provided by HGNC Official Full Name purinergic receptor P2X 1provided by HGNC Primary source HGNC:HGNC:8533 See related Ensembl:ENSG00000108405 MIM:600845; AllianceGenome:HGNC:8533 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X1 Summary The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013] Expression Broad expression in bone marrow (RPKM 20.3), urinary bladder (RPKM 20.1) and 15 other tissues See more Orthologs mouse all
P2RX2, Official Symbol P2RX2provided by HGNC Official Full Name purinergic receptor P2X 2provided by HGNC Primary source HGNC:HGNC:15459 See related Ensembl:ENSG00000187848 MIM:600844; AllianceGenome:HGNC:15459 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X2; DFNA41 Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013] Expression Biased expression in prostate (RPKM 1.9), spleen (RPKM 0.8) and 13 other tissues See more Orthologs mouse all
P2RX3, Official Symbol P2RX3provided by HGNC Official Full Name purinergic receptor P2X 3provided by HGNC Primary source HGNC:HGNC:8534 See related Ensembl:ENSG00000109991 MIM:600843; AllianceGenome:HGNC:8534 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X3 Summary This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017] Expression Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues See more Orthologs mouse all
P2RX4, Official Symbol P2RX4provided by HGNC Official Full Name purinergic receptor P2X 4provided by HGNC Primary source HGNC:HGNC:8535 See related Ensembl:ENSG00000135124 MIM:600846; AllianceGenome:HGNC:8535 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X4; P2X4R Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in placenta (RPKM 18.6), colon (RPKM 15.4) and 25 other tissues See more Orthologs mouse all
P2RX5, Official Symbol P2RX5provided by HGNC Official Full Name purinergic receptor P2X 5provided by HGNC Primary source HGNC:HGNC:8536 See related Ensembl:ENSG00000083454 MIM:602836; AllianceGenome:HGNC:8536 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X5; LRH-1; P2X5R Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011] Expression Biased expression in lymph node (RPKM 41.6), spleen (RPKM 36.1) and 4 other tissues See more Orthologs mouse all
P2RX5-TAX1BP3, Official Symbol P2RX5-TAX1BP3provided by HGNC Official Full Name P2RX5-TAX1BP3 readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:49191 See related Ensembl:ENSG00000257950 AllianceGenome:HGNC:49191 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X5; P2RX5 Summary This locus represents naturally occurring read-through transcription between the neighboring P2RX5 (purinergic receptor P2X, ligand-gated ion channel, 5) and TAX1BP3 (Tax1 binding protein 3) genes on chromosome 17. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011] Expression Ubiquitous expression in stomach (RPKM 14.5), lymph node (RPKM 14.1) and 25 other tissues See more
P2RX6, Official Symbol P2RX6provided by HGNC Official Full Name purinergic receptor P2X 6provided by HGNC Primary source HGNC:HGNC:8538 See related Ensembl:ENSG00000099957 MIM:608077; AllianceGenome:HGNC:8538 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X6; P2XM; P2RXL1 Summary The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009] Expression Broad expression in spleen (RPKM 2.6), brain (RPKM 2.0) and 17 other tissues See more Orthologs mouse all
P2RX6P, Official Symbol P2RX6Pprovided by HGNC Official Full Name purinergic receptor P2X 6 pseudogeneprovided by HGNC Primary source HGNC:HGNC:34076 See related AllianceGenome:HGNC:34076 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in brain (RPKM 1.4), fat (RPKM 0.5) and 10 other tissues See more
P2RX7, Official Symbol P2RX7provided by HGNC Official Full Name purinergic receptor P2X 7provided by HGNC Primary source HGNC:HGNC:8537 See related Ensembl:ENSG00000089041 MIM:602566; AllianceGenome:HGNC:8537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2X7 Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] Expression Broad expression in brain (RPKM 6.8), skin (RPKM 4.9) and 23 other tissues See more Orthologs mouse all
P2RY1, Official Symbol P2RY1provided by HGNC Official Full Name purinergic receptor P2Y1provided by HGNC Primary source HGNC:HGNC:8539 See related Ensembl:ENSG00000169860 MIM:601167; AllianceGenome:HGNC:8539 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2Y1; SARCC Summary The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008] Orthologs mouse all
P2RY10, Official Symbol P2RY10provided by HGNC Official Full Name P2Y receptor family member 10provided by HGNC Primary source HGNC:HGNC:19906 See related Ensembl:ENSG00000078589 MIM:300529; AllianceGenome:HGNC:19906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPS2; P2Y10; LYPSR2 Summary The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016] Expression Biased expression in lymph node (RPKM 13.0), appendix (RPKM 8.0) and 9 other tissues See more Orthologs mouse all
P2RY10BP, Official Symbol P2RY10BPprovided by HGNC Official Full Name P2Y receptor family member 10B, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32924 See related Ensembl:ENSG00000232168 AllianceGenome:HGNC:32924 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2RY10P2
P2RY11, Official Symbol P2RY11provided by HGNC Official Full Name purinergic receptor P2Y11provided by HGNC Primary source HGNC:HGNC:8540 See related Ensembl:ENSG00000244165 MIM:602697; AllianceGenome:HGNC:8540 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2Y11 Summary The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 6.0), lymph node (RPKM 4.7) and 25 other tissues See more Orthologs all
P2RY12, Official Symbol P2RY12provided by HGNC Official Full Name purinergic receptor P2Y12provided by HGNC Primary source HGNC:HGNC:18124 See related Ensembl:ENSG00000169313 MIM:600515; AllianceGenome:HGNC:18124 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc) Summary The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] Expression Biased expression in brain (RPKM 25.8), fat (RPKM 4.8) and 4 other tissues See more Orthologs mouse all
P2RY13, Official Symbol P2RY13provided by HGNC Official Full Name purinergic receptor P2Y13provided by HGNC Primary source HGNC:HGNC:4537 See related Ensembl:ENSG00000181631 MIM:606380; AllianceGenome:HGNC:4537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPCR1; GPR86; GPR94; P2Y13; SP174; FKSG77 Summary The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008] Expression Broad expression in spleen (RPKM 21.1), appendix (RPKM 14.3) and 18 other tissues See more Orthologs mouse all
P2RY14, Official Symbol P2RY14provided by HGNC Official Full Name purinergic receptor P2Y14provided by HGNC Primary source HGNC:HGNC:16442 See related Ensembl:ENSG00000174944 MIM:610116; AllianceGenome:HGNC:16442 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2Y14; BPR105; GPR105 Summary The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in esophagus (RPKM 4.9), placenta (RPKM 4.7) and 18 other tissues See more Orthologs mouse all
P2RY2, Official Symbol P2RY2provided by HGNC Official Full Name purinergic receptor P2Y2provided by HGNC Primary source HGNC:HGNC:8541 See related Ensembl:ENSG00000175591 MIM:600041; AllianceGenome:HGNC:8541 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R Summary The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013] Expression Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more Orthologs mouse all
P2RY4, Official Symbol P2RY4provided by HGNC Official Full Name pyrimidinergic receptor P2Y4provided by HGNC Primary source HGNC:HGNC:8542 See related Ensembl:ENSG00000186912 MIM:300038; AllianceGenome:HGNC:8542 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRU; P2P; UNR; P2Y4 Summary The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008] Orthologs mouse all
P2RY6, Official Symbol P2RY6provided by HGNC Official Full Name pyrimidinergic receptor P2Y6provided by HGNC Primary source HGNC:HGNC:8543 See related Ensembl:ENSG00000171631 MIM:602451; AllianceGenome:HGNC:8543 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2Y6 Summary The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013] Expression Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues See more Orthologs mouse all
P2RY8, Official Symbol P2RY8provided by HGNC Official Full Name P2Y receptor family member 8provided by HGNC Primary source HGNC:HGNC:15524 See related Ensembl:ENSG00000182162 Ensembl:ENSG00000292333 MIM:300525; AllianceGenome:HGNC:15524 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P2Y8 Summary The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 13.9), spleen (RPKM 8.9) and 14 other tissues See more Orthologs all