psui3905/ncbi_genes_summary huggingface dataset:
TAB1, Official Symbol TAB1provided by HGNC Official Full Name TGF-beta activated kinase 1 (MAP3K7) binding protein 1provided by HGNC Primary source HGNC:HGNC:18157 See related Ensembl:ENSG00000100324 MIM:602615; AllianceGenome:HGNC:18157 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 3'-Tab1; MAP3K7IP1 Summary The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 7.9), brain (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
TAB2, Official Symbol TAB2provided by HGNC Official Full Name TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by HGNC Primary source HGNC:HGNC:17075 See related Ensembl:ENSG00000055208 MIM:605101; AllianceGenome:HGNC:17075 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHTD2; TAB-2; MAP3K7IP2 Summary The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
TAB2-AS1, Official Symbol TAB2-AS1provided by HGNC Official Full Name TAB2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53508 See related Ensembl:ENSG00000225924 AllianceGenome:HGNC:53508 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
TAB3, Official Symbol TAB3provided by HGNC Official Full Name TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by HGNC Primary source HGNC:HGNC:30681 See related Ensembl:ENSG00000157625 MIM:300480; AllianceGenome:HGNC:30681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAP1; MAP3K7IP3 Summary The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
TAB3-AS2, Official Symbol TAB3-AS2provided by HGNC Official Full Name TAB3 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40013 See related AllianceGenome:HGNC:40013 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
TAB3P1, Official Symbol TAB3P1provided by HGNC Official Full Name TGF-beta activated kinase 1/MAP3K7 binding protein 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:37723 See related Ensembl:ENSG00000235462 AllianceGenome:HGNC:37723 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAC1, Official Symbol TAC1provided by HGNC Official Full Name tachykinin precursor 1provided by HGNC Primary source HGNC:HGNC:11517 See related Ensembl:ENSG00000006128 MIM:162320; AllianceGenome:HGNC:11517 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NK2; NPK; NKNA; TAC2; Hs.2563 Summary This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] Expression Biased expression in brain (RPKM 24.6), spleen (RPKM 12.4) and 6 other tissues See more Orthologs mouse all
TAC3, Official Symbol TAC3provided by HGNC Official Full Name tachykinin precursor 3provided by HGNC Primary source HGNC:HGNC:11521 See related Ensembl:ENSG00000166863 MIM:162330; AllianceGenome:HGNC:11521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NK3; NKB; HH10; NKNB; PRO1155; ZNEUROK1; LncZBTB39 Summary This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] Expression Restricted expression toward placenta (RPKM 93.9) See more Orthologs mouse all
TAC4, Official Symbol TAC4provided by HGNC Official Full Name tachykinin precursor 4provided by HGNC Primary source HGNC:HGNC:16641 See related Ensembl:ENSG00000176358 MIM:607833; AllianceGenome:HGNC:16641 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EK; HK1; HK-1; PPT-C Summary This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Low expression observed in reference dataset See more Orthologs mouse all
TACC1, Official Symbol TACC1provided by HGNC Official Full Name transforming acidic coiled-coil containing protein 1provided by HGNC Primary source HGNC:HGNC:11522 See related Ensembl:ENSG00000147526 MIM:605301; AllianceGenome:HGNC:11522 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Ga55 Summary This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017] Expression Ubiquitous expression in fat (RPKM 59.1), endometrium (RPKM 38.3) and 24 other tissues See more Orthologs mouse all
TACC2, Official Symbol TACC2provided by HGNC Official Full Name transforming acidic coiled-coil containing protein 2provided by HGNC Primary source HGNC:HGNC:11523 See related Ensembl:ENSG00000138162 MIM:605302; AllianceGenome:HGNC:11523 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AZU-1; ECTACC Summary Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in heart (RPKM 17.2), skin (RPKM 13.6) and 19 other tissues See more Orthologs mouse all
TACC3, Official Symbol TACC3provided by HGNC Official Full Name transforming acidic coiled-coil containing protein 3provided by HGNC Primary source HGNC:HGNC:11524 See related Ensembl:ENSG00000013810 MIM:605303; AllianceGenome:HGNC:11524 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERIC1; Tacc4; ERIC-1; maskin Summary This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011] Expression Broad expression in testis (RPKM 25.6), bone marrow (RPKM 24.9) and 16 other tissues See more Orthologs mouse all
TACO1, Official Symbol TACO1provided by HGNC Official Full Name translational activator of cytochrome c oxidase Iprovided by HGNC Primary source HGNC:HGNC:24316 See related Ensembl:ENSG00000136463 MIM:612958; AllianceGenome:HGNC:24316 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCDC44; MC4DN8 Summary This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010] Expression Ubiquitous expression in kidney (RPKM 17.5), liver (RPKM 13.0) and 25 other tissues See more Orthologs mouse all
TACR1, Official Symbol TACR1provided by HGNC Official Full Name tachykinin receptor 1provided by HGNC Primary source HGNC:HGNC:11526 See related Ensembl:ENSG00000115353 MIM:162323; AllianceGenome:HGNC:11526 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPR; NK1R; NKIR; TAC1R Summary This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] Expression Broad expression in skin (RPKM 1.8), endometrium (RPKM 1.4) and 17 other tissues See more Orthologs mouse all
TACR2, Official Symbol TACR2provided by HGNC Official Full Name tachykinin receptor 2provided by HGNC Primary source HGNC:HGNC:11527 See related Ensembl:ENSG00000075073 MIM:162321; AllianceGenome:HGNC:11527 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SKR; NK2R; NKNAR; TAC2R Summary This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 8.8), endometrium (RPKM 7.3) and 9 other tissues See more Orthologs mouse all
TACR3, Official Symbol TACR3provided by HGNC Official Full Name tachykinin receptor 3provided by HGNC Primary source HGNC:HGNC:11528 See related Ensembl:ENSG00000169836 MIM:162332; AllianceGenome:HGNC:11528 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NK3; NKR; HH11; NK3R; NK-3R; TAC3R; TAC3RL Summary This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
TACSTD2, Official Symbol TACSTD2provided by HGNC Official Full Name tumor associated calcium signal transducer 2provided by HGNC Primary source HGNC:HGNC:11530 See related Ensembl:ENSG00000184292 MIM:137290; AllianceGenome:HGNC:11530 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1 Summary This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009] Orthologs mouse all
TADA1, Official Symbol TADA1provided by HGNC Official Full Name transcriptional adaptor 1provided by HGNC Primary source HGNC:HGNC:30631 See related Ensembl:ENSG00000152382 MIM:612763; AllianceGenome:HGNC:30631 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADA1; HFI1; hADA1; STAF42; TADA1L Summary TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009] Expression Ubiquitous expression in brain (RPKM 9.2), bone marrow (RPKM 7.8) and 25 other tissues See more Orthologs mouse all
TADA2A, Official Symbol TADA2Aprovided by HGNC Official Full Name transcriptional adaptor 2Aprovided by HGNC Primary source HGNC:HGNC:11531 See related Ensembl:ENSG00000276234 MIM:602276; AllianceGenome:HGNC:11531 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADA2; ADA2A; KL04P; hADA2; TADA2L Summary Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009] Annotation information Note: ADA2 is an official symbol GeneID: 51816 and an alias on GeneID: 687. GeneID: 6871 is frequently referred to as ADA2 in the literature, and publications belonging to GeneID:51816 are sometimes mis-associated with GeneID: 6871 [06 Jul 2018] Expression Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 4.5) and 25 other tissues See more Orthologs mouse all
TADA2B, Official Symbol TADA2Bprovided by HGNC Official Full Name transcriptional adaptor 2Bprovided by HGNC Primary source HGNC:HGNC:30781 See related Ensembl:ENSG00000173011 MIM:608790; AllianceGenome:HGNC:30781 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADA2B; ADA2(beta) Summary TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010] Expression Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 7.9) and 25 other tissues See more Orthologs mouse all
TADA3, Official Symbol TADA3provided by HGNC Official Full Name transcriptional adaptor 3provided by HGNC Primary source HGNC:HGNC:19422 See related Ensembl:ENSG00000171148 MIM:602945; AllianceGenome:HGNC:19422 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADA3; NGG1; hADA3; STAF54; TADA3L Summary DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] Expression Ubiquitous expression in testis (RPKM 21.9), ovary (RPKM 20.9) and 25 other tissues See more Orthologs mouse all
TAF1, Official Symbol TAF1provided by HGNC Official Full Name TATA-box binding protein associated factor 1provided by HGNC Primary source HGNC:HGNC:11535 See related Ensembl:ENSG00000147133 MIM:313650; AllianceGenome:HGNC:11535 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; MRXS33; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250 Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013] Expression Ubiquitous expression in thyroid (RPKM 5.8), endometrium (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
TAF10, Official Symbol TAF10provided by HGNC Official Full Name TATA-box binding protein associated factor 10provided by HGNC Primary source HGNC:HGNC:11543 See related Ensembl:ENSG00000166337 MIM:600475; AllianceGenome:HGNC:11543 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAF2A; TAF2H; TAFII30 Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 44.4), testis (RPKM 44.3) and 25 other tissues See more Orthologs mouse all
TAF11, Official Symbol TAF11provided by HGNC Official Full Name TATA-box binding protein associated factor 11provided by HGNC Primary source HGNC:HGNC:11544 See related Ensembl:ENSG00000064995 MIM:600772; AllianceGenome:HGNC:11544 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAF2I; PRO2134; TAFII28; MGC:15243 Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in testis (RPKM 12.6), bone marrow (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
TAF11L10, Official Symbol TAF11L10provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 10provided by HGNC Primary source HGNC:HGNC:53853 See related Ensembl:ENSG00000284356 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAF11L11, Official Symbol TAF11L11provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 11provided by HGNC Primary source HGNC:HGNC:53854 See related Ensembl:ENSG00000283740 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAF11L12, Official Symbol TAF11L12provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 12provided by HGNC Primary source HGNC:HGNC:53855 See related Ensembl:ENSG00000249156 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAF11L13, Official Symbol TAF11L13provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 13provided by HGNC Primary source HGNC:HGNC:53856 See related Ensembl:ENSG00000283776 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAF11L14, Official Symbol TAF11L14provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 14provided by HGNC Primary source HGNC:HGNC:53857 See related Ensembl:ENSG00000250782 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAF11L2, Official Symbol TAF11L2provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 2provided by HGNC Primary source HGNC:HGNC:53845 See related Ensembl:ENSG00000284373 AllianceGenome:HGNC:53845 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
TAF11L3, Official Symbol TAF11L3provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 3provided by HGNC Primary source HGNC:HGNC:53846 See related Ensembl:ENSG00000284439 AllianceGenome:HGNC:53846 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
TAF11L4, Official Symbol TAF11L4provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 4provided by HGNC Primary source HGNC:HGNC:53847 See related Ensembl:ENSG00000284283 AllianceGenome:HGNC:53847 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
TAF11L5, Official Symbol TAF11L5provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 5provided by HGNC Primary source HGNC:HGNC:53848 See related Ensembl:ENSG00000284234 AllianceGenome:HGNC:53848 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
TAF11L6, Official Symbol TAF11L6provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 6provided by HGNC Primary source HGNC:HGNC:53849 See related Ensembl:ENSG00000284042 AllianceGenome:HGNC:53849 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
TAF11L7, Official Symbol TAF11L7provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 7provided by HGNC Primary source HGNC:HGNC:53850 See related Ensembl:ENSG00000284465 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAF11L5
TAF11L8, Official Symbol TAF11L8provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 8provided by HGNC Primary source HGNC:HGNC:53851 See related Ensembl:ENSG00000283967 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAF11L9, Official Symbol TAF11L9provided by HGNC Official Full Name TATA-box binding protein associated factor 11 like 9provided by HGNC Primary source HGNC:HGNC:53852 See related Ensembl:ENSG00000283988 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs all
TAF12, Official Symbol TAF12provided by HGNC Official Full Name TATA-box binding protein associated factor 12provided by HGNC Primary source HGNC:HGNC:11545 See related Ensembl:ENSG00000120656 MIM:600773; AllianceGenome:HGNC:11545 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAF2J; TAFII20 Summary Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in testis (RPKM 9.9), lymph node (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
TAF13, Official Symbol TAF13provided by HGNC Official Full Name TATA-box binding protein associated factor 13provided by HGNC Primary source HGNC:HGNC:11546 See related Ensembl:ENSG00000197780 MIM:600774; AllianceGenome:HGNC:11546 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT60; TAF2K; TAFII18; TAFII-18; TAF(II)18 Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 23.1), kidney (RPKM 21.3) and 25 other tissues See more Orthologs mouse all
TAF13P2, Official Symbol TAF13P2provided by HGNC Official Full Name TATA-box binding protein associated factor 13 pseudogene 2provided by HGNC Primary source HGNC:HGNC:38161 See related Ensembl:ENSG00000225658 AllianceGenome:HGNC:38161 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TAF15, Official Symbol TAF15provided by HGNC Official Full Name TATA-box binding protein associated factor 15provided by HGNC Primary source HGNC:HGNC:11547 See related Ensembl:ENSG00000270647 MIM:601574; AllianceGenome:HGNC:11547 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Npl3; RBP56; TAF2N; TAFII68 Summary This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] Expression Ubiquitous expression in testis (RPKM 46.3), lymph node (RPKM 45.2) and 25 other tissues See more Orthologs mouse all
TAF1A, Official Symbol TAF1Aprovided by HGNC Official Full Name TATA-box binding protein associated factor, RNA polymerase I subunit Aprovided by HGNC Primary source HGNC:HGNC:11532 See related Ensembl:ENSG00000143498 MIM:604903; AllianceGenome:HGNC:11532 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SL1; RAFI48; TAFI48; MGC:17061 Summary This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011] Expression Ubiquitous expression in testis (RPKM 2.3), lymph node (RPKM 1.9) and 24 other tissues See more Orthologs mouse all
TAF1A-AS1, Official Symbol TAF1A-AS1provided by HGNC Official Full Name TAF1A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40573 See related Ensembl:ENSG00000225265 AllianceGenome:HGNC:40573 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 3.6), thyroid (RPKM 2.6) and 23 other tissues See more
TAF1B, Official Symbol TAF1Bprovided by HGNC Official Full Name TATA-box binding protein associated factor, RNA polymerase I subunit Bprovided by HGNC Primary source HGNC:HGNC:11533 See related Ensembl:ENSG00000115750 MIM:604904; AllianceGenome:HGNC:11533 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SL1; RAF1B; RAFI63; TAFI63; MGC:9349 Summary Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in testis (RPKM 5.9), placenta (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
TAF1C, Official Symbol TAF1Cprovided by HGNC Official Full Name TATA-box binding protein associated factor, RNA polymerase I subunit Cprovided by HGNC Primary source HGNC:HGNC:11534 See related Ensembl:ENSG00000103168 MIM:604905; AllianceGenome:HGNC:11534 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SL1; TAFI95; TAFI110; MGC:39976 Summary Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011] Expression Ubiquitous expression in spleen (RPKM 19.0), ovary (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
TAF1D, Official Symbol TAF1Dprovided by HGNC Official Full Name TATA-box binding protein associated factor, RNA polymerase I subunit Dprovided by HGNC Primary source HGNC:HGNC:28759 See related Ensembl:ENSG00000166012 MIM:612823; AllianceGenome:HGNC:28759 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JOSD3; RAFI41; TAFI41; TAF(I)41 Summary TAF1D is a member of the SL1 complex, which includes TBP (MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C (MIM 604905), and plays a role in RNA polymerase I transcription (Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed 17318177]).[supplied by OMIM, Jun 2009] Expression Ubiquitous expression in lymph node (RPKM 25.5), appendix (RPKM 22.4) and 25 other tissues See more Orthologs mouse all
TAF1L, Official Symbol TAF1Lprovided by HGNC Official Full Name TATA-box binding protein associated factor 1 likeprovided by HGNC Primary source HGNC:HGNC:18056 See related Ensembl:ENSG00000122728 MIM:607798; AllianceGenome:HGNC:18056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAF2A2; TAF(II)210 Summary This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. [provided by RefSeq, Aug 2015] Orthologs all
TAF2, Official Symbol TAF2provided by HGNC Official Full Name TATA-box binding protein associated factor 2provided by HGNC Primary source HGNC:HGNC:11536 See related Ensembl:ENSG00000064313 MIM:604912; AllianceGenome:HGNC:11536 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT40; TAF2B; CIF150; TAFII150 Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
TAF3, Official Symbol TAF3provided by HGNC Official Full Name TATA-box binding protein associated factor 3provided by HGNC Primary source HGNC:HGNC:17303 See related Ensembl:ENSG00000165632 MIM:606576; AllianceGenome:HGNC:17303 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAF140; TAFII140; TAFII-140 Summary The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009] Expression Ubiquitous expression in testis (RPKM 5.8), ovary (RPKM 3.8) and 25 other tissues See more Orthologs mouse all