psui3905/ncbi_genes_summary huggingface dataset:
WDR86-AS1, Official Symbol WDR86-AS1provided by HGNC Official Full Name WDR86 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41186 See related Ensembl:ENSG00000243836 AllianceGenome:HGNC:41186 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in spleen (RPKM 7.2), thyroid (RPKM 3.6) and 7 other tissues See more
WDR87, Official Symbol WDR87provided by HGNC Official Full Name WD repeat domain 87provided by HGNC Primary source HGNC:HGNC:29934 See related Ensembl:ENSG00000171804 MIM:620274; AllianceGenome:HGNC:29934 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NYD-SP11 Expression Restricted expression toward testis (RPKM 11.3) See more Orthologs mouse all
WDR88, Official Symbol WDR88provided by HGNC Official Full Name WD repeat domain 88provided by HGNC Primary source HGNC:HGNC:26999 See related Ensembl:ENSG00000166359 AllianceGenome:HGNC:26999 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PQWD Expression Broad expression in testis (RPKM 2.4), thyroid (RPKM 0.5) and 23 other tissues See more Orthologs mouse all
WDR89, Official Symbol WDR89provided by HGNC Official Full Name WD repeat domain 89provided by HGNC Primary source HGNC:HGNC:20489 See related Ensembl:ENSG00000140006 AllianceGenome:HGNC:20489 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSTP050; C14orf150 Expression Ubiquitous expression in lymph node (RPKM 4.5), thyroid (RPKM 4.4) and 25 other tissues See more Orthologs mouse all
WDR90, Official Symbol WDR90provided by HGNC Official Full Name WD repeat domain 90provided by HGNC Primary source HGNC:HGNC:26960 See related Ensembl:ENSG00000161996 MIM:618290; AllianceGenome:HGNC:26960 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POC16; C16orf15; C16orf16; C16orf17; C16orf18; C16orf19 Summary Involved in cilium assembly. Located in centriole. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 12.0), bone marrow (RPKM 4.3) and 23 other tissues See more Orthologs mouse all
WDR91, Official Symbol WDR91provided by HGNC Official Full Name WD repeat domain 91provided by HGNC Primary source HGNC:HGNC:24997 See related Ensembl:ENSG00000105875 MIM:616303; AllianceGenome:HGNC:24997 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SORF1; SORF-1; HSPC049 Summary Enables phosphatidylinositol 3-kinase regulator activity. Involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Located in cytosol; early endosome membrane; and late endosome membrane. Is extrinsic component of endosome membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues See more Orthologs mouse all
WDR93, Official Symbol WDR93provided by HGNC Official Full Name WD repeat domain 93provided by HGNC Primary source HGNC:HGNC:26924 See related Ensembl:ENSG00000140527 MIM:619891; AllianceGenome:HGNC:26924 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1d-87; FAP297; CFAP297 Summary Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in electron transport chain. Predicted to be part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 3.2), prostate (RPKM 0.4) and 3 other tissues See more Orthologs mouse all
WDR95P, Official Symbol WDR95Pprovided by HGNC Official Full Name WD repeat domain 95, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42637 See related AllianceGenome:HGNC:42637 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
WDR97, Official Symbol WDR97provided by HGNC Official Full Name WD repeat domain 97provided by HGNC Primary source HGNC:HGNC:26959 See related Ensembl:ENSG00000179698 AllianceGenome:HGNC:26959 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA1875 Summary The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. [provided by RefSeq, Oct 2008] Expression Biased expression in testis (RPKM 5.3), brain (RPKM 0.6) and 9 other tissues See more Orthologs mouse all
WDSUB1, Official Symbol WDSUB1provided by HGNC Official Full Name WD repeat, sterile alpha motif and U-box domain containing 1provided by HGNC Primary source HGNC:HGNC:26697 See related Ensembl:ENSG00000196151 AllianceGenome:HGNC:26697 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBOX6; WDSAM1 Summary Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 5.8), kidney (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
WDTC1, Official Symbol WDTC1provided by HGNC Official Full Name WD and tetratricopeptide repeats 1provided by HGNC Primary source HGNC:HGNC:29175 See related Ensembl:ENSG00000142784 MIM:619763; AllianceGenome:HGNC:29175 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADP; DCAF9 Summary Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 28.2), heart (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
WEE1, Official Symbol WEE1provided by HGNC Official Full Name WEE1 G2 checkpoint kinaseprovided by HGNC Primary source HGNC:HGNC:12761 See related Ensembl:ENSG00000166483 MIM:193525; AllianceGenome:HGNC:12761 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WEE1A; WEE1hu Summary This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in gall bladder (RPKM 23.7), esophagus (RPKM 19.4) and 22 other tissues See more Orthologs mouse all
WEE2, Official Symbol WEE2provided by HGNC Official Full Name WEE2 oocyte meiosis inhibiting kinaseprovided by HGNC Primary source HGNC:HGNC:19684 See related Ensembl:ENSG00000214102 MIM:614084; AllianceGenome:HGNC:19684 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OOMD5; WEE1B; OZEMA5 Summary Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of meiosis I. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
WEE2-AS1, Official Symbol WEE2-AS1provided by HGNC Official Full Name WEE2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:48669 See related Ensembl:ENSG00000228775 AllianceGenome:HGNC:48669 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 1.2), ovary (RPKM 0.9) and 25 other tissues See more
WFDC1, Official Symbol WFDC1provided by HGNC Official Full Name WAP four-disulfide core domain 1provided by HGNC Primary source HGNC:HGNC:15466 See related Ensembl:ENSG00000103175 MIM:605322; AllianceGenome:HGNC:15466 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PS20 Summary This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Biased expression in placenta (RPKM 49.5), prostate (RPKM 33.0) and 13 other tissues See more Orthologs mouse all
WFDC10A, Official Symbol WFDC10Aprovided by HGNC Official Full Name WAP four-disulfide core domain 10Aprovided by HGNC Primary source HGNC:HGNC:16139 See related Ensembl:ENSG00000180305 AllianceGenome:HGNC:16139 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP10; C20orf146; dJ688G8.3 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
WFDC10B, Official Symbol WFDC10Bprovided by HGNC Official Full Name WAP four-disulfide core domain 10Bprovided by HGNC Primary source HGNC:HGNC:20479 See related Ensembl:ENSG00000182931 AllianceGenome:HGNC:20479 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP12 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
WFDC11, Official Symbol WFDC11provided by HGNC Official Full Name WAP four-disulfide core domain 11provided by HGNC Primary source HGNC:HGNC:20478 See related Ensembl:ENSG00000180083 AllianceGenome:HGNC:20478 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP11 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 1.2) See more Orthologs mouse all
WFDC12, Official Symbol WFDC12provided by HGNC Official Full Name WAP four-disulfide core domain 12provided by HGNC Primary source HGNC:HGNC:16115 See related Ensembl:ENSG00000168703 MIM:609872; AllianceGenome:HGNC:16115 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP2; SWAM2; C20orf122; dJ211D12.4 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 13.5) and esophagus (RPKM 0.8) See more Orthologs all
WFDC13, Official Symbol WFDC13provided by HGNC Official Full Name WAP four-disulfide core domain 13provided by HGNC Primary source HGNC:HGNC:16131 See related Ensembl:ENSG00000168634 AllianceGenome:HGNC:16131 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP13; C20orf138; dJ601O1.3 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
WFDC2, Official Symbol WFDC2provided by HGNC Official Full Name WAP four-disulfide core domain 2provided by HGNC Primary source HGNC:HGNC:15939 See related Ensembl:ENSG00000101443 MIM:617548; AllianceGenome:HGNC:15939 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HE4; WAP5; EDDM4; dJ461P17.6 Summary This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008] Expression Biased expression in salivary gland (RPKM 317.9), endometrium (RPKM 117.3) and 8 other tissues See more Orthologs mouse all
WFDC21P, Official Symbol WFDC21Pprovided by HGNC Official Full Name WAP four-disulfide core domain 21, pseudogeneprovided by HGNC Primary source HGNC:HGNC:50357 See related Ensembl:ENSG00000261040 MIM:615772; AllianceGenome:HGNC:50357 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LNCDC; lnc-DC; linc-DC Summary Predicted to enable enzyme activator activity. Predicted to act upstream of or within response to lipopolysaccharide; response to tumor necrosis factor; and white fat cell differentiation. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in esophagus (RPKM 17.0), skin (RPKM 14.1) and 7 other tissues See more
WFDC3, Official Symbol WFDC3provided by HGNC Official Full Name WAP four-disulfide core domain 3provided by HGNC Primary source HGNC:HGNC:15957 See related Ensembl:ENSG00000124116 AllianceGenome:HGNC:15957 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP14; dJ447F3.3 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 19.8) See more Orthologs mouse all
WFDC5, Official Symbol WFDC5provided by HGNC Official Full Name WAP four-disulfide core domain 5provided by HGNC Primary source HGNC:HGNC:20477 See related Ensembl:ENSG00000175121 MIM:605161; AllianceGenome:HGNC:20477 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRG5; WAP1; dJ211D12.5 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008] Expression Restricted expression toward skin (RPKM 102.0) See more Orthologs all
WFDC6, Official Symbol WFDC6provided by HGNC Official Full Name WAP four-disulfide core domain 6provided by HGNC Primary source HGNC:HGNC:16164 See related Ensembl:ENSG00000243543 AllianceGenome:HGNC:16164 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP6; C20orf171; HEL-S-295; dJ461P17.11 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010] Expression Restricted expression toward testis (RPKM 26.2) See more Orthologs all
WFDC8, Official Symbol WFDC8provided by HGNC Official Full Name WAP four-disulfide core domain 8provided by HGNC Primary source HGNC:HGNC:16163 See related Ensembl:ENSG00000158901 AllianceGenome:HGNC:16163 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP8; C20orf170; HEL-S-292; dJ461P17.1 Summary This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
WFDC9, Official Symbol WFDC9provided by HGNC Official Full Name WAP four-disulfide core domain 9provided by HGNC Primary source HGNC:HGNC:20380 See related Ensembl:ENSG00000180205 AllianceGenome:HGNC:20380 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WAP9; dJ688G8.2 Summary The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. [provided by RefSeq, Jul 2008] Orthologs mouse all
WFIKKN1, Official Symbol WFIKKN1provided by HGNC Official Full Name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1provided by HGNC Primary source HGNC:HGNC:30912 See related Ensembl:ENSG00000127578 MIM:608021; AllianceGenome:HGNC:30912 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RJD2; WFIKKN; WFDC20A; C16orf12 Summary This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
WFIKKN2, Official Symbol WFIKKN2provided by HGNC Official Full Name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by HGNC Primary source HGNC:HGNC:30916 See related Ensembl:ENSG00000173714 MIM:610895; AllianceGenome:HGNC:30916 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GASP-1; WFDC20B; hGASP-1; WFIKKNRP Summary The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008] Expression Biased expression in ovary (RPKM 30.8) and testis (RPKM 1.8) See more Orthologs mouse all
WFS1, Official Symbol WFS1provided by HGNC Official Full Name wolframin ER transmembrane glycoproteinprovided by HGNC Primary source HGNC:HGNC:12762 See related Ensembl:ENSG00000109501 MIM:606201; AllianceGenome:HGNC:12762 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WFS; WFRS; WFSL; CTRCT41 Summary This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in ovary (RPKM 44.4), fat (RPKM 34.2) and 24 other tissues See more Orthologs mouse all
WHAMM, Official Symbol WHAMMprovided by HGNC Official Full Name WASP homolog associated with actin, golgi membranes and microtubulesprovided by HGNC Primary source HGNC:HGNC:30493 See related Ensembl:ENSG00000156232 MIM:612393; AllianceGenome:HGNC:30493 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WHDC1; WHAMM1 Summary This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in bone marrow (RPKM 8.9), spleen (RPKM 2.9) and 24 other tissues See more Orthologs mouse all
WHRN, Official Symbol WHRNprovided by HGNC Official Full Name whirlinprovided by HGNC Primary source HGNC:HGNC:16361 See related Ensembl:ENSG00000095397 MIM:607928; AllianceGenome:HGNC:16361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WI; CIP98; USH2D; DFNB31; PDZD7B Summary This gene is thought to function in the organization and stabilization of sterocilia elongation and actin cystoskeletal assembly, based on studies of the related mouse gene. Mutations in this gene have been associated with autosomal recessive non-syndromic deafness and Usher Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] Expression Broad expression in adrenal (RPKM 14.4), testis (RPKM 9.7) and 18 other tissues See more Orthologs mouse all
WHSC1L2P, Official Symbol WHSC1L2Pprovided by HGNC Official Full Name Wolf-Hirschhorn syndrome candidate 1-like 2, pseudogeneprovided by HGNC Primary source HGNC:HGNC:14647 See related Ensembl:ENSG00000267253 AllianceGenome:HGNC:14647 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSD4P; HsT36289; WHSC1L1P
WIF1, Official Symbol WIF1provided by HGNC Official Full Name WNT inhibitory factor 1provided by HGNC Primary source HGNC:HGNC:18081 See related Ensembl:ENSG00000156076 MIM:605186; AllianceGenome:HGNC:18081 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WIF-1 Summary The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010] Expression Biased expression in lung (RPKM 69.2), brain (RPKM 9.8) and 3 other tissues See more Orthologs mouse all
WIPF1, Official Symbol WIPF1provided by HGNC Official Full Name WAS/WASL interacting protein family member 1provided by HGNC Primary source HGNC:HGNC:12736 See related Ensembl:ENSG00000115935 MIM:602357; AllianceGenome:HGNC:12736 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WIP; WAS2; PRPL-2; WASPIP Summary This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 61.9), appendix (RPKM 50.1) and 23 other tissues See more Orthologs mouse all
WIPF2, Official Symbol WIPF2provided by HGNC Official Full Name WAS/WASL interacting protein family member 2provided by HGNC Primary source HGNC:HGNC:30923 See related Ensembl:ENSG00000171475 MIM:609692; AllianceGenome:HGNC:30923 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WICH; WIRE Summary This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 10.6), colon (RPKM 7.8) and 25 other tissues See more Orthologs mouse all
WIPF3, Official Symbol WIPF3provided by HGNC Official Full Name WAS/WASL interacting protein family member 3provided by HGNC Primary source HGNC:HGNC:22004 See related Ensembl:ENSG00000122574 MIM:612432; AllianceGenome:HGNC:22004 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CR16 Summary Predicted to enable SH3 domain binding activity and actin binding activity. Predicted to be involved in actin filament-based movement. Predicted to be located in cytosol. Predicted to be active in actin filament. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in ovary (RPKM 20.0), testis (RPKM 14.2) and 10 other tissues See more Orthologs mouse all
WIPI1, Official Symbol WIPI1provided by HGNC Official Full Name WD repeat domain, phosphoinositide interacting 1provided by HGNC Primary source HGNC:HGNC:25471 See related Ensembl:ENSG00000070540 MIM:609224; AllianceGenome:HGNC:25471 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATG18; ATG18A; WIPI49 Summary This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in placenta (RPKM 11.9), heart (RPKM 11.3) and 25 other tissues See more Orthologs mouse all
WIPI2, Official Symbol WIPI2provided by HGNC Official Full Name WD repeat domain, phosphoinositide interacting 2provided by HGNC Primary source HGNC:HGNC:32225 See related Ensembl:ENSG00000157954 MIM:609225; AllianceGenome:HGNC:32225 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Atg21; ATG18B; CGI-50; IDDSSA; WIPI-2 Summary WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in testis (RPKM 20.8), brain (RPKM 12.7) and 25 other tissues See more Orthologs mouse all
WIZ, Official Symbol WIZprovided by HGNC Official Full Name WIZ zinc fingerprovided by HGNC Primary source HGNC:HGNC:30917 See related Ensembl:ENSG00000011451 MIM:619715; AllianceGenome:HGNC:30917 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF803 Summary Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 8.9), fat (RPKM 6.6) and 25 other tissues See more Orthologs mouse all
WLS, Official Symbol WLSprovided by HGNC Official Full Name Wnt ligand secretion mediatorprovided by HGNC Primary source HGNC:HGNC:30238 See related Ensembl:ENSG00000116729 MIM:611514; AllianceGenome:HGNC:30238 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EVI; MRP; ZKS; GPR177; mig-14; C1orf139 Summary Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 32.7), gall bladder (RPKM 31.7) and 24 other tissues See more Orthologs mouse all
WNK1, Official Symbol WNK1provided by HGNC Official Full Name WNK lysine deficient protein kinase 1provided by HGNC Primary source HGNC:HGNC:14540 See related Ensembl:ENSG00000060237 MIM:605232; AllianceGenome:HGNC:14540 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167 Summary This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010] Expression Ubiquitous expression in kidney (RPKM 30.2), fat (RPKM 24.6) and 25 other tissues See more Orthologs mouse all
WNK2, Official Symbol WNK2provided by HGNC Official Full Name WNK lysine deficient protein kinase 2provided by HGNC Primary source HGNC:HGNC:14542 See related Ensembl:ENSG00000165238 MIM:606249; AllianceGenome:HGNC:14542 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13 Summary The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Broad expression in heart (RPKM 6.5), colon (RPKM 6.3) and 18 other tissues See more Orthologs mouse all
WNK3, Official Symbol WNK3provided by HGNC Official Full Name WNK lysine deficient protein kinase 3provided by HGNC Primary source HGNC:HGNC:14543 See related Ensembl:ENSG00000196632 MIM:300358; AllianceGenome:HGNC:14543 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRKWNK3 Summary This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Biased expression in testis (RPKM 7.2), brain (RPKM 1.1) and 5 other tissues See more Orthologs mouse all
WNK4, Official Symbol WNK4provided by HGNC Official Full Name WNK lysine deficient protein kinase 4provided by HGNC Primary source HGNC:HGNC:14544 See related Ensembl:ENSG00000126562 MIM:601844; AllianceGenome:HGNC:14544 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PHA2B; PRKWNK4 Summary This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009] Expression Biased expression in kidney (RPKM 12.8), prostate (RPKM 5.7) and 6 other tissues See more Orthologs mouse all
WNT1, Official Symbol WNT1provided by HGNC Official Full Name Wnt family member 1provided by HGNC Primary source HGNC:HGNC:12774 See related Ensembl:ENSG00000125084 MIM:164820; AllianceGenome:HGNC:12774 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT1; OI15; BMND16 Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
WNT10A, Official Symbol WNT10Aprovided by HGNC Official Full Name Wnt family member 10Aprovided by HGNC Primary source HGNC:HGNC:13829 See related Ensembl:ENSG00000135925 MIM:606268; AllianceGenome:HGNC:13829 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OODD; SSPS; ECTD16; STHAG4 Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008] Expression Broad expression in skin (RPKM 3.0), placenta (RPKM 1.8) and 16 other tissues See more Orthologs mouse all
WNT10B, Official Symbol WNT10Bprovided by HGNC Official Full Name Wnt family member 10Bprovided by HGNC Primary source HGNC:HGNC:12775 See related Ensembl:ENSG00000169884 MIM:601906; AllianceGenome:HGNC:12775 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SHFM6; STHAG8; WNT-12 Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 3.0), skin (RPKM 0.8) and 15 other tissues See more Orthologs mouse all
WNT11, Official Symbol WNT11provided by HGNC Official Full Name Wnt family member 11provided by HGNC Primary source HGNC:HGNC:12776 See related Ensembl:ENSG00000085741 MIM:603699; AllianceGenome:HGNC:12776 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HWNT11 Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 7.4), adrenal (RPKM 3.7) and 15 other tissues See more Orthologs mouse all