psui3905/ncbi_genes_summary huggingface dataset:
ME2, Official Symbol ME2provided by HGNC Official Full Name malic enzyme 2provided by HGNC Primary source HGNC:HGNC:6984 See related Ensembl:ENSG00000082212 MIM:154270; AllianceGenome:HGNC:6984 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ODS1 Summary This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in duodenum (RPKM 15.0), colon (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
ME3, Official Symbol ME3provided by HGNC Official Full Name malic enzyme 3provided by HGNC Primary source HGNC:HGNC:6985 See related Ensembl:ENSG00000151376 MIM:604626; AllianceGenome:HGNC:6985 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NADP-ME Summary Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 4.2), fat (RPKM 4.1) and 25 other tissues See more Orthologs mouse all
MEA1, Official Symbol MEA1provided by HGNC Official Full Name male-enhanced antigen 1provided by HGNC Primary source HGNC:HGNC:6986 See related Ensembl:ENSG00000124733 MIM:143170; AllianceGenome:HGNC:6986 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYS; MEA Summary Predicted to be involved in male gonad development. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 41.1), brain (RPKM 13.3) and 25 other tissues See more Orthologs mouse all
MEAF6, Official Symbol MEAF6provided by HGNC Official Full Name MYST/Esa1 associated factor 6provided by HGNC Primary source HGNC:HGNC:25674 See related Ensembl:ENSG00000163875 MIM:611001; AllianceGenome:HGNC:25674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAF6; CENP-28; C1orf149; NY-SAR-91 Summary This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in prostate (RPKM 17.1), testis (RPKM 12.4) and 25 other tissues See more Orthologs mouse all
MEAK7, Official Symbol MEAK7provided by HGNC Official Full Name MTOR associated protein, eak-7 homologprovided by HGNC Primary source HGNC:HGNC:29325 See related Ensembl:ENSG00000140950 MIM:619331; AllianceGenome:HGNC:29325 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAK7; TLDC1; mEAK-7; KIAA1609 Summary Involved in several processes, including TOR signaling; positive regulation of protein localization to lysosome; and response to insulin. Located in cytosol; lysosomal membrane; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 6.1), esophagus (RPKM 5.1) and 23 other tissues See more Orthologs mouse all
MECOM, Official Symbol MECOMprovided by HGNC Official Full Name MDS1 and EVI1 complex locusprovided by HGNC Primary source HGNC:HGNC:3498 See related Ensembl:ENSG00000085276 MIM:165215; AllianceGenome:HGNC:3498 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EVI1; MDS1; KMT8E; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1 Summary The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Expression Broad expression in stomach (RPKM 15.9), kidney (RPKM 12.6) and 18 other tissues See more Orthologs mouse all
MECOM-AS1, Official Symbol MECOM-AS1provided by HGNC Official Full Name MECOM antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40368 See related Ensembl:ENSG00000241479 AllianceGenome:HGNC:40368 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in esophagus (RPKM 1.4), stomach (RPKM 0.2) and 2 other tissues See more
MECP2, Official Symbol MECP2provided by HGNC Official Full Name methyl-CpG binding protein 2provided by HGNC Primary source HGNC:HGNC:6990 See related Ensembl:ENSG00000169057 MIM:300005; AllianceGenome:HGNC:6990 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13 Summary DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in ovary (RPKM 10.4), brain (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
MECR, Official Symbol MECRprovided by HGNC Official Full Name mitochondrial trans-2-enoyl-CoA reductaseprovided by HGNC Primary source HGNC:HGNC:19691 See related Ensembl:ENSG00000116353 MIM:608205; AllianceGenome:HGNC:19691 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ETR1; NRBF1; CGI-63; FASN2B; DYTOABG Summary The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy. [provided by RefSeq, Mar 2017] Expression Ubiquitous expression in fat (RPKM 6.2), brain (RPKM 3.9) and 25 other tissues See more Orthologs mouse all
MED1, Official Symbol MED1provided by HGNC Official Full Name mediator complex subunit 1provided by HGNC Primary source HGNC:HGNC:9234 See related Ensembl:ENSG00000125686 MIM:604311; AllianceGenome:HGNC:9234 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220 Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 8.1), appendix (RPKM 7.7) and 25 other tissues See more Orthologs mouse all
MED10, Official Symbol MED10provided by HGNC Official Full Name mediator complex subunit 10provided by HGNC Primary source HGNC:HGNC:28760 See related Ensembl:ENSG00000133398 MIM:612382; AllianceGenome:HGNC:28760 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L6; NUT2; TRG20 Summary MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008] Expression Ubiquitous expression in bone marrow (RPKM 22.5), lymph node (RPKM 18.2) and 25 other tissues See more Orthologs mouse all
MED11, Official Symbol MED11provided by HGNC Official Full Name mediator complex subunit 11provided by HGNC Primary source HGNC:HGNC:32687 See related Ensembl:ENSG00000161920 MIM:612383; AllianceGenome:HGNC:32687 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDDRSB; HSPC296 Summary MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008] Expression Ubiquitous expression in kidney (RPKM 9.3), spleen (RPKM 8.7) and 25 other tissues See more Orthologs mouse all
MED12, Official Symbol MED12provided by HGNC Official Full Name mediator complex subunit 12provided by HGNC Primary source HGNC:HGNC:11957 See related Ensembl:ENSG00000184634 MIM:300188; AllianceGenome:HGNC:11957 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Kto; OKS; FGS1; HDKR; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230 Summary The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009] Expression Ubiquitous expression in ovary (RPKM 11.0), spleen (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
MED12L, Official Symbol MED12Lprovided by HGNC Official Full Name mediator complex subunit 12Lprovided by HGNC Primary source HGNC:HGNC:16050 See related Ensembl:ENSG00000144893 MIM:611318; AllianceGenome:HGNC:16050 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOPAR; TRALP; NIZIDS; TNRC11L; TRALPUSH Summary The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010] Expression Broad expression in testis (RPKM 2.2), brain (RPKM 1.5) and 18 other tissues See more Orthologs mouse all
MED13, Official Symbol MED13provided by HGNC Official Full Name mediator complex subunit 13provided by HGNC Primary source HGNC:HGNC:22474 See related Ensembl:ENSG00000108510 MIM:603808; AllianceGenome:HGNC:22474 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRD61; ARC250; THRAP1; DRIP250; HSPC221; TRAP240 Summary This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
MED13L, Official Symbol MED13Lprovided by HGNC Official Full Name mediator complex subunit 13Lprovided by HGNC Primary source HGNC:HGNC:22962 See related Ensembl:ENSG00000123066 MIM:608771; AllianceGenome:HGNC:22962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRFACD; THRAP2; TRAP240L; PROSIT240 Summary The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010] Expression Ubiquitous expression in bone marrow (RPKM 23.0), ovary (RPKM 14.7) and 25 other tissues See more Orthologs mouse all
MED13P1, Official Symbol MED13P1provided by HGNC Official Full Name mediator complex subunit 13 pseudogene 1provided by HGNC Primary source HGNC:HGNC:38733 See related Ensembl:ENSG00000236131 AllianceGenome:HGNC:38733 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MED14, Official Symbol MED14provided by HGNC Official Full Name mediator complex subunit 14provided by HGNC Primary source HGNC:HGNC:2370 See related Ensembl:ENSG00000180182 MIM:300182; AllianceGenome:HGNC:2370 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170 Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 8.7), duodenum (RPKM 8.0) and 25 other tissues See more Orthologs mouse all
MED14P1, Official Symbol MED14P1provided by HGNC Official Full Name mediator complex subunit 14 pseudogene 1provided by HGNC Primary source HGNC:HGNC:2371 See related Ensembl:ENSG00000233774 AllianceGenome:HGNC:2371 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRSP2P; MED14P; CXorf4P
MED15, Official Symbol MED15provided by HGNC Official Full Name mediator complex subunit 15provided by HGNC Primary source HGNC:HGNC:14248 See related Ensembl:ENSG00000099917 MIM:607372; AllianceGenome:HGNC:14248 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105 Summary The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues See more Orthologs mouse all
MED15P1, Official Symbol MED15P1provided by HGNC Official Full Name mediator complex subunit 15 pseudogene 1provided by HGNC Primary source HGNC:HGNC:19271 See related AllianceGenome:HGNC:19271 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED15P; PCQAPP
MED15P3, Official Symbol MED15P3provided by HGNC Official Full Name mediator complex subunit 15 pseudogene 3provided by HGNC Primary source HGNC:HGNC:48652 See related Ensembl:ENSG00000226831 AllianceGenome:HGNC:48652 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MED15P9, Official Symbol MED15P9provided by HGNC Official Full Name mediator complex subunit 15 pseudogene 9provided by HGNC Primary source HGNC:HGNC:44130 See related Ensembl:ENSG00000290707 AllianceGenome:HGNC:44130 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED15P2; CCDC74B-AS1 Expression Biased expression in testis (RPKM 1.9), endometrium (RPKM 0.3) and 5 other tissues See more
MED16, Official Symbol MED16provided by HGNC Official Full Name mediator complex subunit 16provided by HGNC Primary source HGNC:HGNC:17556 See related Ensembl:ENSG00000175221 MIM:604062; AllianceGenome:HGNC:17556 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRIP92; THRAP5; TRAP95 Summary Enables thyroid hormone receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation from RNA polymerase II promoter. Located in membrane. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 10.5), kidney (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
MED17, Official Symbol MED17provided by HGNC Official Full Name mediator complex subunit 17provided by HGNC Primary source HGNC:HGNC:2375 See related Ensembl:ENSG00000042429 MIM:603810; AllianceGenome:HGNC:2375 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRB4; CRSP6; CRSP77; DRIP80; TRAP80 Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 8.7), ovary (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
MED18, Official Symbol MED18provided by HGNC Official Full Name mediator complex subunit 18provided by HGNC Primary source HGNC:HGNC:25944 See related Ensembl:ENSG00000130772 MIM:612384; AllianceGenome:HGNC:25944 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRB5; p28b Summary MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008] Expression Ubiquitous expression in colon (RPKM 5.4), lymph node (RPKM 4.8) and 25 other tissues See more Orthologs mouse all
MED19, Official Symbol MED19provided by HGNC Official Full Name mediator complex subunit 19provided by HGNC Primary source HGNC:HGNC:29600 See related Ensembl:ENSG00000156603 MIM:612385; AllianceGenome:HGNC:29600 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCMR1; DT2P1G7; MED19AS Summary The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in testis (RPKM 7.0), brain (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
MED20, Official Symbol MED20provided by HGNC Official Full Name mediator complex subunit 20provided by HGNC Primary source HGNC:HGNC:16840 See related Ensembl:ENSG00000124641 MIM:612915; AllianceGenome:HGNC:16840 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRB2; TRFP; PRO0213 Summary This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015] Expression Ubiquitous expression in placenta (RPKM 6.7), thyroid (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
MED21, Official Symbol MED21provided by HGNC Official Full Name mediator complex subunit 21provided by HGNC Primary source HGNC:HGNC:11473 See related Ensembl:ENSG00000152944 MIM:603800; AllianceGenome:HGNC:11473 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRB7; SURB7; hSrb7 Summary This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] Expression Ubiquitous expression in adrenal (RPKM 13.1), testis (RPKM 11.0) and 25 other tissues See more Orthologs mouse all
MED22, Official Symbol MED22provided by HGNC Official Full Name mediator complex subunit 22provided by HGNC Primary source HGNC:HGNC:11477 See related Ensembl:ENSG00000148297 MIM:185641; AllianceGenome:HGNC:11477 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRB6; MED24; SURF5; surf-5 Summary This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in ovary (RPKM 8.5), thyroid (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
MED23, Official Symbol MED23provided by HGNC Official Full Name mediator complex subunit 23provided by HGNC Primary source HGNC:HGNC:2372 See related Ensembl:ENSG00000112282 MIM:605042; AllianceGenome:HGNC:2372 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SUR2; CRSP3; MRT18; SUR-2; ARC130; CRSP130; CRSP133; DRIP130 Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 9.5), lymph node (RPKM 8.5) and 25 other tissues See more Orthologs mouse all
MED24, Official Symbol MED24provided by HGNC Official Full Name mediator complex subunit 24provided by HGNC Primary source HGNC:HGNC:22963 See related Ensembl:ENSG00000008838 MIM:607000; AllianceGenome:HGNC:22963 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED5; CRSP4; ARC100; THRAP4; CRSP100; DRIP100; TRAP100 Summary This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.9), brain (RPKM 13.4) and 25 other tissues See more Orthologs mouse all
MED25, Official Symbol MED25provided by HGNC Official Full Name mediator complex subunit 25provided by HGNC Primary source HGNC:HGNC:28845 See related Ensembl:ENSG00000104973 MIM:610197; AllianceGenome:HGNC:28845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758 Summary This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010] Expression Broad expression in testis (RPKM 24.2), adrenal (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
MED26, Official Symbol MED26provided by HGNC Official Full Name mediator complex subunit 26provided by HGNC Primary source HGNC:HGNC:2376 See related Ensembl:ENSG00000105085 MIM:605043; AllianceGenome:HGNC:2376 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRSP7; CRSP70 Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 18.2), bone marrow (RPKM 6.2) and 23 other tissues See more Orthologs mouse all
MED27, Official Symbol MED27provided by HGNC Official Full Name mediator complex subunit 27provided by HGNC Primary source HGNC:HGNC:2377 See related Ensembl:ENSG00000160563 MIM:605044; AllianceGenome:HGNC:2377 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED3; CRSP8; CRAP34; CRSP34; TRAP37; NEDSCAC Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 2.0) and 25 other tissues See more Orthologs mouse all
MED28, Official Symbol MED28provided by HGNC Official Full Name mediator complex subunit 28provided by HGNC Primary source HGNC:HGNC:24628 See related Ensembl:ENSG00000118579 MIM:610311; AllianceGenome:HGNC:24628 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EG1; magicin; 1500003D12Rik Summary Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and stem cell population maintenance. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 18.1), placenta (RPKM 17.9) and 25 other tissues See more Orthologs mouse all
MED28P1, Official Symbol MED28P1provided by HGNC Official Full Name mediator complex subunit 28 pseudogene 1provided by HGNC Primary source HGNC:HGNC:45078 See related AllianceGenome:HGNC:45078 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MED28P2, Official Symbol MED28P2provided by HGNC Official Full Name mediator complex subunit 28 pseudogene 2provided by HGNC Primary source HGNC:HGNC:45079 See related Ensembl:ENSG00000240511 AllianceGenome:HGNC:45079 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MED28P3, Official Symbol MED28P3provided by HGNC Official Full Name mediator complex subunit 28 pseudogene 3provided by HGNC Primary source HGNC:HGNC:45080 See related Ensembl:ENSG00000227692 AllianceGenome:HGNC:45080 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MED28P5, Official Symbol MED28P5provided by HGNC Official Full Name mediator complex subunit 28 pseudogene 5provided by HGNC Primary source HGNC:HGNC:45082 See related Ensembl:ENSG00000255205 AllianceGenome:HGNC:45082 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MED28P6, Official Symbol MED28P6provided by HGNC Official Full Name mediator complex subunit 28 pseudogene 6provided by HGNC Primary source HGNC:HGNC:45083 See related Ensembl:ENSG00000259183 AllianceGenome:HGNC:45083 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MED29, Official Symbol MED29provided by HGNC Official Full Name mediator complex subunit 29provided by HGNC Primary source HGNC:HGNC:23074 See related Ensembl:ENSG00000063322 MIM:612914; AllianceGenome:HGNC:23074 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IXL; MED2 Summary MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009] Expression Ubiquitous expression in brain (RPKM 2.7), thyroid (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
MED30, Official Symbol MED30provided by HGNC Official Full Name mediator complex subunit 30provided by HGNC Primary source HGNC:HGNC:23032 See related Ensembl:ENSG00000164758 MIM:610237; AllianceGenome:HGNC:23032 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED30S; THRAP6; TRAP25 Summary The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010] Expression Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 5.0) and 24 other tissues See more Orthologs mouse all
MED31, Official Symbol MED31provided by HGNC Official Full Name mediator complex subunit 31provided by HGNC Primary source HGNC:HGNC:24260 See related Ensembl:ENSG00000108590 MIM:620492; AllianceGenome:HGNC:24260 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Soh1; SEP10; CGI-125; 3110004H13Rik Summary Predicted to enable transcription coregulator activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within limb development and negative regulation of fibroblast proliferation. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.0), adrenal (RPKM 4.6) and 25 other tissues See more Orthologs mouse all
MED4, Official Symbol MED4provided by HGNC Official Full Name mediator complex subunit 4provided by HGNC Primary source HGNC:HGNC:17903 See related Ensembl:ENSG00000136146 MIM:605718; AllianceGenome:HGNC:17903 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC36; VDRIP; DRIP36; TRAP36; HSPC126 Summary This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
MED4-AS1, Official Symbol MED4-AS1provided by HGNC Official Full Name MED4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39213 See related Ensembl:ENSG00000229111 AllianceGenome:HGNC:39213 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED4-AS Expression Ubiquitous expression in duodenum (RPKM 35.0), esophagus (RPKM 27.8) and 25 other tissues See more
MED6, Official Symbol MED6provided by HGNC Official Full Name mediator complex subunit 6provided by HGNC Primary source HGNC:HGNC:19970 See related Ensembl:ENSG00000133997 MIM:602984; AllianceGenome:HGNC:19970 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC33; NY-REN-28 Summary Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 6.4), ovary (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
MED7, Official Symbol MED7provided by HGNC Official Full Name mediator complex subunit 7provided by HGNC Primary source HGNC:HGNC:2378 See related Ensembl:ENSG00000155868 MIM:605045; AllianceGenome:HGNC:2378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC34; CRSP9; CRSP33 Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
MED8, Official Symbol MED8provided by HGNC Official Full Name mediator complex subunit 8provided by HGNC Primary source HGNC:HGNC:19971 See related Ensembl:ENSG00000159479 MIM:607956; AllianceGenome:HGNC:19971 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARC32 Summary This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in thyroid (RPKM 12.7), placenta (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
MED9, Official Symbol MED9provided by HGNC Official Full Name mediator complex subunit 9provided by HGNC Primary source HGNC:HGNC:25487 See related Ensembl:ENSG00000141026 MIM:609878; AllianceGenome:HGNC:25487 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MED25 Summary The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
MEDAG, Official Symbol MEDAGprovided by HGNC Official Full Name mesenteric estrogen dependent adipogenesisprovided by HGNC Primary source HGNC:HGNC:25926 See related Ensembl:ENSG00000102802 AllianceGenome:HGNC:25926 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AWMS3; MEDA4; MEDA-4; hAWMS3; C13orf33 Summary Predicted to be involved in positive regulation of fat cell differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in urinary bladder (RPKM 9.4), appendix (RPKM 6.9) and 19 other tissues See more Orthologs mouse all