psui3905/ncbi_genes_summary huggingface dataset:
LRRC49, Official Symbol LRRC49provided by HGNC Official Full Name leucine rich repeat containing 49provided by HGNC Primary source HGNC:HGNC:25965 See related Ensembl:ENSG00000137821 MIM:620497; AllianceGenome:HGNC:25965 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGs4; CSTPP2 Summary Predicted to be involved in outer dynein arm assembly. Predicted to be located in microtubule. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in heart (RPKM 8.5), testis (RPKM 7.2) and 19 other tissues See more Orthologs mouse all
LRRC4B, Official Symbol LRRC4Bprovided by HGNC Official Full Name leucine rich repeat containing 4Bprovided by HGNC Primary source HGNC:HGNC:25042 See related Ensembl:ENSG00000131409 AllianceGenome:HGNC:25042 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSM; LRIG4; NGL-3 Summary Predicted to enable signaling receptor binding activity. Predicted to be involved in regulation of synapse assembly and synaptic membrane adhesion. Predicted to be located in cerebellar mossy fiber and presynaptic membrane. Predicted to be active in glutamatergic synapse and plasma membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 11.1), endometrium (RPKM 2.3) and 4 other tissues See more Orthologs mouse all
LRRC4C, Official Symbol LRRC4Cprovided by HGNC Official Full Name leucine rich repeat containing 4Cprovided by HGNC Primary source HGNC:HGNC:29317 See related Ensembl:ENSG00000148948 MIM:608817; AllianceGenome:HGNC:29317 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NGL1; NGL-1 Summary NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008] Expression Biased expression in brain (RPKM 5.3), adrenal (RPKM 0.7) and 1 other tissue See more Orthologs mouse all
LRRC52, Official Symbol LRRC52provided by HGNC Official Full Name leucine rich repeat containing 52provided by HGNC Primary source HGNC:HGNC:32156 See related Ensembl:ENSG00000162763 MIM:615218; AllianceGenome:HGNC:32156 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 7.8) See more Orthologs mouse all
LRRC52-AS1, Official Symbol LRRC52-AS1provided by HGNC Official Full Name LRRC52 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54044 See related Ensembl:ENSG00000237463 AllianceGenome:HGNC:54044 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 2.7), heart (RPKM 0.3) and 1 other tissue See more
LRRC53, Official Symbol LRRC53provided by HGNC Official Full Name leucine rich repeat containing 53provided by HGNC Primary source HGNC:HGNC:25255 See related Ensembl:ENSG00000162621 AllianceGenome:HGNC:25255 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
LRRC55, Official Symbol LRRC55provided by HGNC Official Full Name leucine rich repeat containing 55provided by HGNC Primary source HGNC:HGNC:32324 See related Ensembl:ENSG00000183908 MIM:615213; AllianceGenome:HGNC:32324 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 2.8), lymph node (RPKM 1.5) and 14 other tissues See more Orthologs mouse all
LRRC56, Official Symbol LRRC56provided by HGNC Official Full Name leucine rich repeat containing 56provided by HGNC Primary source HGNC:HGNC:25430 See related Ensembl:ENSG00000161328 MIM:618227; AllianceGenome:HGNC:25430 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CILD39; DNAAF12 Summary Predicted to be involved in cell projection organization. Predicted to be located in cilium. Implicated in primary ciliary dyskinesia 39. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 4.5), skin (RPKM 0.8) and 17 other tissues See more Orthologs mouse all
LRRC57, Official Symbol LRRC57provided by HGNC Official Full Name leucine rich repeat containing 57provided by HGNC Primary source HGNC:HGNC:26719 See related Ensembl:ENSG00000180979 AllianceGenome:HGNC:26719 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 9.0), placenta (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
LRRC57P1, Official Symbol LRRC57P1provided by HGNC Official Full Name LRRC57 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54680 See related AllianceGenome:HGNC:54680 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LRRC58, Official Symbol LRRC58provided by HGNC Official Full Name leucine rich repeat containing 58provided by HGNC Primary source HGNC:HGNC:26968 See related Ensembl:ENSG00000163428 AllianceGenome:HGNC:26968 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in adrenal (RPKM 14.9), thyroid (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
LRRC59, Official Symbol LRRC59provided by HGNC Official Full Name leucine rich repeat containing 59provided by HGNC Primary source HGNC:HGNC:28817 See related Ensembl:ENSG00000108829 MIM:614854; AllianceGenome:HGNC:28817 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p34; PRO1855 Summary Enables RNA binding activity and cadherin binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. Located in endoplasmic reticulum and mitochondrial nucleoid. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 47.1), stomach (RPKM 37.6) and 25 other tissues See more Orthologs mouse all
LRRC61, Official Symbol LRRC61provided by HGNC Official Full Name leucine rich repeat containing 61provided by HGNC Primary source HGNC:HGNC:21704 See related Ensembl:ENSG00000127399 AllianceGenome:HGNC:21704 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSPC295 Summary Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 5.1), adrenal (RPKM 4.0) and 25 other tissues See more Orthologs mouse all
LRRC63, Official Symbol LRRC63provided by HGNC Official Full Name leucine rich repeat containing 63provided by HGNC Primary source HGNC:HGNC:34296 See related Ensembl:ENSG00000173988 AllianceGenome:HGNC:34296 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 1.5), prostate (RPKM 0.2) and 3 other tissues See more Orthologs mouse all
LRRC66, Official Symbol LRRC66provided by HGNC Official Full Name leucine rich repeat containing 66provided by HGNC Primary source HGNC:HGNC:34299 See related Ensembl:ENSG00000188993 AllianceGenome:HGNC:34299 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. [provided by RefSeq, Apr 2017] Expression Biased expression in duodenum (RPKM 4.6), small intestine (RPKM 4.1) and 4 other tissues See more Orthologs mouse all
LRRC69, Official Symbol LRRC69provided by HGNC Official Full Name leucine rich repeat containing 69provided by HGNC Primary source HGNC:HGNC:34303 See related Ensembl:ENSG00000214954 AllianceGenome:HGNC:34303 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 1.3), lymph node (RPKM 0.4) and 19 other tissues See more Orthologs mouse all
LRRC7, Official Symbol LRRC7provided by HGNC Official Full Name leucine rich repeat containing 7provided by HGNC Primary source HGNC:HGNC:18531 See related Ensembl:ENSG00000033122 MIM:614453; AllianceGenome:HGNC:18531 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DENSIN Summary Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of neuron projection development; and receptor clustering. Located in several cellular components, including centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 2.3), testis (RPKM 0.6) and 2 other tissues See more Orthologs mouse all
LRRC70, Official Symbol LRRC70provided by HGNC Official Full Name leucine rich repeat containing 70provided by HGNC Primary source HGNC:HGNC:35155 See related Ensembl:ENSG00000186105 AllianceGenome:HGNC:35155 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLRN Summary Involved in positive regulation of response to cytokine stimulus. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 4.2), thyroid (RPKM 3.6) and 22 other tissues See more Orthologs mouse all
LRRC71, Official Symbol LRRC71provided by HGNC Official Full Name leucine rich repeat containing 71provided by HGNC Primary source HGNC:HGNC:26556 See related Ensembl:ENSG00000160838 AllianceGenome:HGNC:26556 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1orf92 Expression Restricted expression toward testis (RPKM 8.7) See more Orthologs mouse all
LRRC72, Official Symbol LRRC72provided by HGNC Official Full Name leucine rich repeat containing 72provided by HGNC Primary source HGNC:HGNC:42972 See related Ensembl:ENSG00000205858 AllianceGenome:HGNC:42972 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAP279; CFAP279 Expression Restricted expression toward testis (RPKM 1.2) See more Orthologs mouse all
LRRC73, Official Symbol LRRC73provided by HGNC Official Full Name leucine rich repeat containing 73provided by HGNC Primary source HGNC:HGNC:21375 See related Ensembl:ENSG00000204052 AllianceGenome:HGNC:21375 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6orf154 Expression Biased expression in testis (RPKM 12.8), brain (RPKM 2.3) and 2 other tissues See more Orthologs mouse all
LRRC74A, Official Symbol LRRC74Aprovided by HGNC Official Full Name leucine rich repeat containing 74Aprovided by HGNC Primary source HGNC:HGNC:23346 See related Ensembl:ENSG00000100565 AllianceGenome:HGNC:23346 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC74; C14orf166B Expression Restricted expression toward testis (RPKM 2.8) See more Orthologs mouse all
LRRC74B, Official Symbol LRRC74Bprovided by HGNC Official Full Name leucine rich repeat containing 74Bprovided by HGNC Primary source HGNC:HGNC:34301 See related Ensembl:ENSG00000187905 AllianceGenome:HGNC:34301 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 1.1), lung (RPKM 0.6) and 1 other tissue See more Orthologs mouse all
LRRC75A, Official Symbol LRRC75Aprovided by HGNC Official Full Name leucine rich repeat containing 75Aprovided by HGNC Primary source HGNC:HGNC:32403 See related Ensembl:ENSG00000181350 AllianceGenome:HGNC:32403 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM211A; C17orf76 Summary Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in urinary bladder (RPKM 22.4), thyroid (RPKM 17.1) and 21 other tissues See more Orthologs mouse all
LRRC75B, Official Symbol LRRC75Bprovided by HGNC Official Full Name leucine rich repeat containing 75Bprovided by HGNC Primary source HGNC:HGNC:33155 See related Ensembl:ENSG00000178026 AllianceGenome:HGNC:33155 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM211B; C22orf36 Summary Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in prostate (RPKM 10.6), thyroid (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
LRRC77P, Official Symbol LRRC77Pprovided by HGNC Official Full Name leucine rich repeat containing 77, pseudogeneprovided by HGNC Primary source HGNC:HGNC:50536 See related Ensembl:ENSG00000244227 AllianceGenome:HGNC:50536 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01330 Expression Biased expression in testis (RPKM 2.0), heart (RPKM 0.7) and 2 other tissues See more
LRRC8A, Official Symbol LRRC8Aprovided by HGNC Official Full Name leucine rich repeat containing 8 VRAC subunit Aprovided by HGNC Primary source HGNC:HGNC:19027 See related Ensembl:ENSG00000136802 MIM:608360; AllianceGenome:HGNC:19027 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGM5; LRRC8; SWELL1; HsLRRC8A Summary This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 27.9), esophagus (RPKM 16.9) and 25 other tissues See more Orthologs mouse all
LRRC8B, Official Symbol LRRC8Bprovided by HGNC Official Full Name leucine rich repeat containing 8 VRAC subunit Bprovided by HGNC Primary source HGNC:HGNC:30692 See related Ensembl:ENSG00000197147 MIM:612888; AllianceGenome:HGNC:30692 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TALRRP; TA-LRRP Summary Contributes to volume-sensitive anion channel activity. Involved in anion transmembrane transport. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. Part of ion channel complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 8.6), adrenal (RPKM 5.3) and 25 other tissues See more Orthologs mouse all
LRRC8C, Official Symbol LRRC8Cprovided by HGNC Official Full Name leucine rich repeat containing 8 VRAC subunit Cprovided by HGNC Primary source HGNC:HGNC:25075 See related Ensembl:ENSG00000171488 MIM:612889; AllianceGenome:HGNC:25075 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD158; FAD158 Summary Enables volume-sensitive anion channel activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 7.4), lymph node (RPKM 5.7) and 24 other tissues See more Orthologs mouse all
LRRC8C-DT, Official Symbol LRRC8C-DTprovided by HGNC Official Full Name LRRC8C divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53731 See related Ensembl:ENSG00000231999 AllianceGenome:HGNC:53731 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 6.3), ovary (RPKM 1.3) and 14 other tissues See more
LRRC8D, Official Symbol LRRC8Dprovided by HGNC Official Full Name leucine rich repeat containing 8 VRAC subunit Dprovided by HGNC Primary source HGNC:HGNC:16992 See related Ensembl:ENSG00000171492 MIM:612890; AllianceGenome:HGNC:16992 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC5; HsLRRC8D Summary Enables volume-sensitive anion channel activity. Involved in cellular response to osmotic stress; organic acid transport; and protein hexamerization. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. Part of ion channel complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 8.5), brain (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
LRRC8D-DT, Official Symbol LRRC8D-DTprovided by HGNC Official Full Name LRRC8D divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55186 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
LRRC8E, Official Symbol LRRC8Eprovided by HGNC Official Full Name leucine rich repeat containing 8 VRAC subunit Eprovided by HGNC Primary source HGNC:HGNC:26272 See related Ensembl:ENSG00000171017 MIM:612891; AllianceGenome:HGNC:26272 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012] Expression Broad expression in skin (RPKM 1.3), prostate (RPKM 0.9) and 17 other tissues See more Orthologs mouse all
LRRC9, Official Symbol LRRC9provided by HGNC Official Full Name leucine rich repeat containing 9provided by HGNC Primary source HGNC:HGNC:19848 See related Ensembl:ENSG00000131951 AllianceGenome:HGNC:19848 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 3.9) See more Orthologs mouse all
LRRCC1, Official Symbol LRRCC1provided by HGNC Official Full Name leucine rich repeat and coiled-coil centrosomal protein 1provided by HGNC Primary source HGNC:HGNC:29373 See related Ensembl:ENSG00000133739 MIM:617791; AllianceGenome:HGNC:29373 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAP2; VFL1; CLERC; CLERK Summary This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. [provided by RefSeq, Mar 2017] Expression Broad expression in testis (RPKM 21.8), thyroid (RPKM 6.5) and 23 other tissues See more Orthologs mouse all
LRRD1, Official Symbol LRRD1provided by HGNC Official Full Name leucine rich repeats and death domain containing 1provided by HGNC Primary source HGNC:HGNC:34300 See related Ensembl:ENSG00000240720 AllianceGenome:HGNC:34300 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 7.7) See more Orthologs mouse all
LRRFIP1, Official Symbol LRRFIP1provided by HGNC Official Full Name LRR binding FLII interacting protein 1provided by HGNC Primary source HGNC:HGNC:6702 See related Ensembl:ENSG00000124831 MIM:603256; AllianceGenome:HGNC:6702 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1 Summary Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lung (RPKM 14.3), bone marrow (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
LRRFIP1P1, Official Symbol LRRFIP1P1provided by HGNC Official Full Name LRR binding FLII interacting protein 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:32937 See related AllianceGenome:HGNC:32937 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LRRFIP2, Official Symbol LRRFIP2provided by HGNC Official Full Name LRR binding FLII interacting protein 2provided by HGNC Primary source HGNC:HGNC:6703 See related Ensembl:ENSG00000093167 MIM:614043; AllianceGenome:HGNC:6703 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HUFI-2 Summary The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in testis (RPKM 17.9), heart (RPKM 16.5) and 25 other tissues See more Orthologs mouse all
LRRFIP2P1, Official Symbol LRRFIP2P1provided by HGNC Official Full Name LRRFIP2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54992 See related Ensembl:ENSG00000237014 AllianceGenome:HGNC:54992 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LRRIQ1, Official Symbol LRRIQ1provided by HGNC Official Full Name leucine rich repeats and IQ motif containing 1provided by HGNC Primary source HGNC:HGNC:25708 See related Ensembl:ENSG00000133640 AllianceGenome:HGNC:25708 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 3.9), lung (RPKM 0.9) and 4 other tissues See more Orthologs mouse all
LRRIQ3, Official Symbol LRRIQ3provided by HGNC Official Full Name leucine rich repeats and IQ motif containing 3provided by HGNC Primary source HGNC:HGNC:28318 See related Ensembl:ENSG00000162620 MIM:617957; AllianceGenome:HGNC:28318 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC44 Expression Biased expression in testis (RPKM 6.2) and fat (RPKM 0.4) See more Orthologs mouse all
LRRIQ4, Official Symbol LRRIQ4provided by HGNC Official Full Name leucine rich repeats and IQ motif containing 4provided by HGNC Primary source HGNC:HGNC:34298 See related Ensembl:ENSG00000188306 AllianceGenome:HGNC:34298 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC64 Summary Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 1.1), colon (RPKM 0.3) and 5 other tissues See more Orthologs mouse all
LRRK1, Official Symbol LRRK1provided by HGNC Official Full Name leucine rich repeat kinase 1provided by HGNC Primary source HGNC:HGNC:18608 See related Ensembl:ENSG00000154237 MIM:610986; AllianceGenome:HGNC:18608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSMD; RIPK6; Roco1 Summary This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in lymph node (RPKM 6.0), spleen (RPKM 4.4) and 24 other tissues See more Orthologs mouse all
LRRK2, Official Symbol LRRK2provided by HGNC Official Full Name leucine rich repeat kinase 2provided by HGNC Primary source HGNC:HGNC:18618 See related Ensembl:ENSG00000188906 MIM:609007; AllianceGenome:HGNC:18618 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PARK8; RIPK7; ROCO2; AURA17; DARDARIN Summary This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] Expression Broad expression in lung (RPKM 31.3), appendix (RPKM 7.6) and 15 other tissues See more Orthologs mouse all
LRRN2, Official Symbol LRRN2provided by HGNC Official Full Name leucine rich repeat neuronal 2provided by HGNC Primary source HGNC:HGNC:16914 See related Ensembl:ENSG00000170382 MIM:605492; AllianceGenome:HGNC:16914 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAC1; LRRN5; LRANK1; FIGLER7 Summary The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 5.5), kidney (RPKM 2.6) and 20 other tissues See more Orthologs mouse all
LRRN3, Official Symbol LRRN3provided by HGNC Official Full Name leucine rich repeat neuronal 3provided by HGNC Primary source HGNC:HGNC:17200 See related Ensembl:ENSG00000173114 MIM:619748; AllianceGenome:HGNC:17200 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NLRR3; NLRR-3; FIGLER5 Summary Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in adrenal (RPKM 13.7), brain (RPKM 11.9) and 12 other tissues See more Orthologs mouse all
LRRN4, Official Symbol LRRN4provided by HGNC Official Full Name leucine rich repeat neuronal 4provided by HGNC Primary source HGNC:HGNC:16208 See related Ensembl:ENSG00000125872 MIM:619706; AllianceGenome:HGNC:16208 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NLRR4; NLRR-4; C20orf75; dJ1056H1.1 Summary Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lung (RPKM 6.4) and kidney (RPKM 1.0) See more Orthologs mouse all
LRRN4CL, Official Symbol LRRN4CLprovided by HGNC Official Full Name LRRN4 C-terminal likeprovided by HGNC Primary source HGNC:HGNC:33724 See related Ensembl:ENSG00000177363 AllianceGenome:HGNC:33724 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in ovary (RPKM 6.0), endometrium (RPKM 5.9) and 17 other tissues See more Orthologs mouse all
LRRTM1, Official Symbol LRRTM1provided by HGNC Official Full Name leucine rich repeat transmembrane neuronal 1provided by HGNC Primary source HGNC:HGNC:19408 See related Ensembl:ENSG00000162951 MIM:610867; AllianceGenome:HGNC:19408 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in regulation of postsynaptic density assembly and regulation of presynapse assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Located in endoplasmic reticulum and growth cone. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 4.5), salivary gland (RPKM 2.3) and 7 other tissues See more Orthologs mouse all
LRRTM2, Official Symbol LRRTM2provided by HGNC Official Full Name leucine rich repeat transmembrane neuronal 2provided by HGNC Primary source HGNC:HGNC:19409 See related Ensembl:ENSG00000146006 MIM:610868; AllianceGenome:HGNC:19409 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable neurexin family protein binding activity. Predicted to be involved in regulation of postsynaptic density assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 12.7), placenta (RPKM 1.4) and 2 other tissues See more Orthologs mouse all
LRRTM3, Official Symbol LRRTM3provided by HGNC Official Full Name leucine rich repeat transmembrane neuronal 3provided by HGNC Primary source HGNC:HGNC:19410 See related Ensembl:ENSG00000198739 MIM:610869; AllianceGenome:HGNC:19410 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in presynapse assembly. Acts upstream of or within positive regulation of amyloid-beta formation. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 4.5), adrenal (RPKM 1.0) and 2 other tissues See more Orthologs mouse all
LRRTM4, Official Symbol LRRTM4provided by HGNC Official Full Name leucine rich repeat transmembrane neuronal 4provided by HGNC Primary source HGNC:HGNC:19411 See related Ensembl:ENSG00000176204 MIM:610870; AllianceGenome:HGNC:19411 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable heparan sulfate proteoglycan binding activity. Predicted to be involved in regulation of synapse assembly. Predicted to act upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular matrix; extracellular space; and glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 5.6) and lung (RPKM 0.2) See more Orthologs mouse all
LRRTM4-AS1, Official Symbol LRRTM4-AS1provided by HGNC Official Full Name LRRTM4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40889 See related Ensembl:ENSG00000234653 AllianceGenome:HGNC:40889 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
LRSAM1, Official Symbol LRSAM1provided by HGNC Official Full Name leucine rich repeat and sterile alpha motif containing 1provided by HGNC Primary source HGNC:HGNC:25135 See related Ensembl:ENSG00000148356 MIM:610933; AllianceGenome:HGNC:25135 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAL; CMT2P; RIFLE Summary This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012] Expression Ubiquitous expression in skin (RPKM 9.6), bone marrow (RPKM 7.7) and 24 other tissues See more Orthologs mouse all
LRTM1, Official Symbol LRTM1provided by HGNC Official Full Name leucine rich repeats and transmembrane domains 1provided by HGNC Primary source HGNC:HGNC:25023 See related Ensembl:ENSG00000144771 AllianceGenome:HGNC:25023 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HT017 Summary Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in spleen (RPKM 2.9), esophagus (RPKM 1.8) and 1 other tissue See more Orthologs mouse all
LRTM2, Official Symbol LRTM2provided by HGNC Official Full Name leucine rich repeats and transmembrane domains 2provided by HGNC Primary source HGNC:HGNC:32443 See related Ensembl:ENSG00000166159 AllianceGenome:HGNC:32443 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward brain (RPKM 3.3) See more Orthologs mouse all
LRTOMT, Official Symbol LRTOMTprovided by HGNC Official Full Name leucine rich transmembrane and O-methyltransferase domain containingprovided by HGNC Primary source HGNC:HGNC:25033 See related Ensembl:ENSG00000284922 MIM:612414; AllianceGenome:HGNC:25033 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOMT; DFNB63; LRRC51; CFAP111; LRRC51-TOMT Summary This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021] Expression Broad expression in testis (RPKM 6.2), thyroid (RPKM 2.2) and 25 other tissues See more Orthologs all
LRWD1, Official Symbol LRWD1provided by HGNC Official Full Name leucine rich repeats and WD repeat domain containing 1provided by HGNC Primary source HGNC:HGNC:21769 See related Ensembl:ENSG00000161036 MIM:615167; AllianceGenome:HGNC:21769 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORCA; CENP-33 Summary The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] Expression Biased expression in testis (RPKM 101.1) and bone marrow (RPKM 5.9) See more Orthologs mouse all
LSAMP, Official Symbol LSAMPprovided by HGNC Official Full Name limbic system associated membrane proteinprovided by HGNC Primary source HGNC:HGNC:6705 See related Ensembl:ENSG00000185565 MIM:603241; AllianceGenome:HGNC:6705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAMP; IGLON3 Summary This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Biased expression in brain (RPKM 19.9), prostate (RPKM 5.4) and 9 other tissues See more Orthologs mouse all
LSAMP-AS1, Official Symbol LSAMP-AS1provided by HGNC Official Full Name LSAMP antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40350 See related Ensembl:ENSG00000240922 AllianceGenome:HGNC:40350 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more