psui3905/ncbi_genes_summary huggingface dataset:
TSSK2, Official Symbol TSSK2provided by HGNC Official Full Name testis specific serine kinase 2provided by HGNC Primary source HGNC:HGNC:11401 See related Ensembl:ENSG00000206203 MIM:610710; AllianceGenome:HGNC:11401 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSK2; DGS-G; SPOGA2; STK22B Summary TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008] Orthologs mouse all
TSSK3, Official Symbol TSSK3provided by HGNC Official Full Name testis specific serine kinase 3provided by HGNC Primary source HGNC:HGNC:15473 See related Ensembl:ENSG00000162526 MIM:607660; AllianceGenome:HGNC:15473 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSK3; SPOGA3; STK22C; STK22D Summary This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 12.3), bone marrow (RPKM 7.8) and 23 other tissues See more Orthologs mouse all
TSSK4, Official Symbol TSSK4provided by HGNC Official Full Name testis specific serine kinase 4provided by HGNC Primary source HGNC:HGNC:19825 See related Ensembl:ENSG00000139908 MIM:610711; AllianceGenome:HGNC:19825 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSK4; TSK-4; TSSK5; STK22E; C14orf20 Summary This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Expression Broad expression in testis (RPKM 10.7), spleen (RPKM 1.5) and 18 other tissues See more Orthologs mouse all
TSSK5P, Official Symbol TSSK5Pprovided by HGNC Official Full Name testis specific serine kinase 5, pseudogeneprovided by HGNC Primary source HGNC:HGNC:31931 See related Ensembl:ENSG00000227473 AllianceGenome:HGNC:31931 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSSK5P1; TSSK5P2; TSSKps1
TSSK6, Official Symbol TSSK6provided by HGNC Official Full Name testis specific serine kinase 6provided by HGNC Primary source HGNC:HGNC:30410 See related Ensembl:ENSG00000178093 MIM:610712; AllianceGenome:HGNC:30410 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT72; SSTK; TSSK4; FKSG82 Summary This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012] Orthologs mouse all
TST, Official Symbol TSTprovided by HGNC Official Full Name thiosulfate sulfurtransferaseprovided by HGNC Primary source HGNC:HGNC:12388 See related Ensembl:ENSG00000128311 MIM:180370; AllianceGenome:HGNC:12388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDS Summary This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Expression Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues See more Orthologs mouse all
TSTD1, Official Symbol TSTD1provided by HGNC Official Full Name thiosulfate sulfurtransferase like domain containing 1provided by HGNC Primary source HGNC:HGNC:35410 See related Ensembl:ENSG00000215845 MIM:616041; AllianceGenome:HGNC:35410 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAT; TST Summary Predicted to enable thiosulfate-thiol sulfurtransferase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Located in cytoplasmic ribonucleoprotein granule and cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 33.0), kidney (RPKM 26.4) and 25 other tissues See more Orthologs mouse all
TSTD2, Official Symbol TSTD2provided by HGNC Official Full Name thiosulfate sulfurtransferase like domain containing 2provided by HGNC Primary source HGNC:HGNC:30087 See related Ensembl:ENSG00000136925 AllianceGenome:HGNC:30087 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C9orf97 Expression Ubiquitous expression in heart (RPKM 18.5), adrenal (RPKM 16.8) and 25 other tissues See more Orthologs mouse all
TSTD3, Official Symbol TSTD3provided by HGNC Official Full Name thiosulfate sulfurtransferase like domain containing 3provided by HGNC Primary source HGNC:HGNC:40910 See related Ensembl:ENSG00000279170 AllianceGenome:HGNC:40910 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 1.4), prostate (RPKM 1.1) and 25 other tissues See more Orthologs mouse all
TTBK1, Official Symbol TTBK1provided by HGNC Official Full Name tau tubulin kinase 1provided by HGNC Primary source HGNC:HGNC:19140 See related Ensembl:ENSG00000146216 MIM:619415; AllianceGenome:HGNC:19140 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDTK Summary Summary:This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. [provided by RefSeq, Jul 2016] Expression Biased expression in brain (RPKM 4.4), small intestine (RPKM 0.9) and 4 other tissues See more Orthologs mouse all
TTBK2, Official Symbol TTBK2provided by HGNC Official Full Name tau tubulin kinase 2provided by HGNC Primary source HGNC:HGNC:19141 See related Ensembl:ENSG00000128881 MIM:611695; AllianceGenome:HGNC:19141 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTBK; SCA11 Summary This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009] Expression Broad expression in testis (RPKM 9.5), brain (RPKM 5.6) and 24 other tissues See more Orthologs mouse all
TTC1, Official Symbol TTC1provided by HGNC Official Full Name tetratricopeptide repeat domain 1provided by HGNC Primary source HGNC:HGNC:12391 See related Ensembl:ENSG00000113312 MIM:601963; AllianceGenome:HGNC:12391 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPR1 Summary This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in brain (RPKM 29.2), heart (RPKM 23.5) and 25 other tissues See more Orthologs mouse all
TTC12, Official Symbol TTC12provided by HGNC Official Full Name tetratricopeptide repeat domain 12provided by HGNC Primary source HGNC:HGNC:23700 See related Ensembl:ENSG00000149292 MIM:610732; AllianceGenome:HGNC:23700 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPARM; CILD45 Summary Involved in axonemal dynein complex assembly and sperm axoneme assembly. Located in centrosome and cytoplasm. Implicated in primary ciliary dyskinesia 45. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 10.6), thyroid (RPKM 3.1) and 21 other tissues See more Orthologs mouse all
TTC13, Official Symbol TTC13provided by HGNC Official Full Name tetratricopeptide repeat domain 13provided by HGNC Primary source HGNC:HGNC:26204 See related Ensembl:ENSG00000143643 AllianceGenome:HGNC:26204 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in lymph node (RPKM 8.0), spleen (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
TTC14, Official Symbol TTC14provided by HGNC Official Full Name tetratricopeptide repeat domain 14provided by HGNC Primary source HGNC:HGNC:24697 See related Ensembl:ENSG00000163728 AllianceGenome:HGNC:24697 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRDL5813; PRO19630 Summary Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 14.0), thyroid (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
TTC16, Official Symbol TTC16provided by HGNC Official Full Name tetratricopeptide repeat domain 16provided by HGNC Primary source HGNC:HGNC:26536 See related Ensembl:ENSG00000167094 AllianceGenome:HGNC:26536 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 9.1), lung (RPKM 0.9) and 2 other tissues See more Orthologs mouse all
TTC17, Official Symbol TTC17provided by HGNC Official Full Name tetratricopeptide repeat domain 17provided by HGNC Primary source HGNC:HGNC:25596 See related Ensembl:ENSG00000052841 MIM:619388; AllianceGenome:HGNC:25596 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in actin filament polymerization and cilium organization. Located in actin cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 14.5), ovary (RPKM 10.5) and 25 other tissues See more Orthologs mouse all
TTC19, Official Symbol TTC19provided by HGNC Official Full Name tetratricopeptide repeat domain 19provided by HGNC Primary source HGNC:HGNC:26006 See related Ensembl:ENSG00000011295 MIM:613814; AllianceGenome:HGNC:26006 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MC3DN2; 2010204O13Rik Summary This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2012] Expression Ubiquitous expression in thyroid (RPKM 8.6), brain (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
TTC21A, Official Symbol TTC21Aprovided by HGNC Official Full Name tetratricopeptide repeat domain 21Aprovided by HGNC Primary source HGNC:HGNC:30761 See related Ensembl:ENSG00000168026 MIM:611430; AllianceGenome:HGNC:30761 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as STI2; Thm2; SPGF37; IFT139A Summary Involved in flagellated sperm motility and spermatid development. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle A. Implicated in spermatogenic failure 37. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 39.0) and lung (RPKM 1.7) See more Orthologs mouse all
TTC21B, Official Symbol TTC21Bprovided by HGNC Official Full Name tetratricopeptide repeat domain 21Bprovided by HGNC Primary source HGNC:HGNC:25660 See related Ensembl:ENSG00000123607 MIM:612014; AllianceGenome:HGNC:25660 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATD4; THM1; FAP60; FLA17; SRTD4; CFAP60; IFT139; JBTS11; NPHP12; IFT139B; Nbla10696 Summary This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat (TPR) domains. This protein is localized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations in this gene are associated with various ciliopathies, nephronophthisis 12, and asphyxiating thoracic dystrophy 4. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in prostate (RPKM 1.9), ovary (RPKM 1.8) and 25 other tissues See more Orthologs mouse all
TTC21B-AS1, Official Symbol TTC21B-AS1provided by HGNC Official Full Name TTC21B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41115 See related AllianceGenome:HGNC:41115 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
TTC22, Official Symbol TTC22provided by HGNC Official Full Name tetratricopeptide repeat domain 22provided by HGNC Primary source HGNC:HGNC:26067 See related Ensembl:ENSG00000006555 AllianceGenome:HGNC:26067 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011] Expression Biased expression in esophagus (RPKM 8.5), colon (RPKM 4.0) and 12 other tissues See more Orthologs mouse all
TTC23, Official Symbol TTC23provided by HGNC Official Full Name tetratricopeptide repeat domain 23provided by HGNC Primary source HGNC:HGNC:25730 See related Ensembl:ENSG00000103852 AllianceGenome:HGNC:25730 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCC-8 Summary Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 4.9), ovary (RPKM 4.2) and 24 other tissues See more Orthologs mouse all
TTC23L, Official Symbol TTC23Lprovided by HGNC Official Full Name tetratricopeptide repeat domain 23 likeprovided by HGNC Primary source HGNC:HGNC:26355 See related Ensembl:ENSG00000205838 MIM:616344; AllianceGenome:HGNC:26355 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MC25-1 Summary Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 3.3), adrenal (RPKM 0.3) and 2 other tissues See more Orthologs mouse all
TTC23L-AS1, Official Symbol TTC23L-AS1provided by HGNC Official Full Name TTC23L antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55215 See related Ensembl:ENSG00000272323 AllianceGenome:HGNC:55215 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in adrenal (RPKM 3.3), thyroid (RPKM 2.4) and 22 other tissues See more
TTC24, Official Symbol TTC24provided by HGNC Official Full Name tetratricopeptide repeat domain 24provided by HGNC Primary source HGNC:HGNC:32348 See related Ensembl:ENSG00000187862 AllianceGenome:HGNC:32348 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in lymph node (RPKM 3.0), spleen (RPKM 1.9) and 3 other tissues See more Orthologs mouse all
TTC27, Official Symbol TTC27provided by HGNC Official Full Name tetratricopeptide repeat domain 27provided by HGNC Primary source HGNC:HGNC:25986 See related Ensembl:ENSG00000018699 AllianceGenome:HGNC:25986 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 8.0), thyroid (RPKM 6.7) and 25 other tissues See more Orthologs mouse all
TTC28, Official Symbol TTC28provided by HGNC Official Full Name tetratricopeptide repeat domain 28provided by HGNC Primary source HGNC:HGNC:29179 See related Ensembl:ENSG00000100154 MIM:615098; AllianceGenome:HGNC:29179 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPRBK Summary Enables kinase binding activity. Involved in regulation of mitotic cell cycle. Located in midbody. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.6) and 24 other tissues See more Orthologs mouse all
TTC28-AS1, Official Symbol TTC28-AS1provided by HGNC Official Full Name TTC28 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:29336 See related Ensembl:ENSG00000235954 AllianceGenome:HGNC:29336 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTC28AS; TTC28-AS; dJ353E16.2 Expression Ubiquitous expression in ovary (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues See more
TTC29, Official Symbol TTC29provided by HGNC Official Full Name tetratricopeptide repeat domain 29provided by HGNC Primary source HGNC:HGNC:29936 See related Ensembl:ENSG00000137473 MIM:618735; AllianceGenome:HGNC:29936 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPGF42; TBPP2A; NYD-SP14 Summary Involved in cilium movement and cilium organization. Located in sperm flagellum. Implicated in spermatogenic failure 42. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 35.8) See more Orthologs mouse all
TTC3, Official Symbol TTC3provided by HGNC Official Full Name tetratricopeptide repeat domain 3provided by HGNC Primary source HGNC:HGNC:12393 See related Ensembl:ENSG00000182670 MIM:602259; AllianceGenome:HGNC:12393 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCRR1; RNF105; TPRDIII Summary Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 28.4), thyroid (RPKM 22.3) and 25 other tissues See more Orthologs mouse all
TTC3-AS1, Official Symbol TTC3-AS1provided by HGNC Official Full Name TTC3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40595 See related Ensembl:ENSG00000228677 AllianceGenome:HGNC:40595 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 3.5), fat (RPKM 2.5) and 25 other tissues See more
TTC31, Official Symbol TTC31provided by HGNC Official Full Name tetratricopeptide repeat domain 31provided by HGNC Primary source HGNC:HGNC:25759 See related Ensembl:ENSG00000115282 AllianceGenome:HGNC:25759 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in duodenum (RPKM 9.8), lymph node (RPKM 9.1) and 25 other tissues See more Orthologs all
TTC32, Official Symbol TTC32provided by HGNC Official Full Name tetratricopeptide repeat domain 32provided by HGNC Primary source HGNC:HGNC:32954 See related Ensembl:ENSG00000183891 AllianceGenome:HGNC:32954 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in bone marrow (RPKM 8.8), prostate (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
TTC33, Official Symbol TTC33provided by HGNC Official Full Name tetratricopeptide repeat domain 33provided by HGNC Primary source HGNC:HGNC:29959 See related Ensembl:ENSG00000113638 AllianceGenome:HGNC:29959 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSRF Expression Ubiquitous expression in brain (RPKM 7.4), thyroid (RPKM 4.0) and 24 other tissues See more Orthologs mouse all
TTC34, Official Symbol TTC34provided by HGNC Official Full Name tetratricopeptide repeat domain 34provided by HGNC Primary source HGNC:HGNC:34297 See related Ensembl:ENSG00000215912 AllianceGenome:HGNC:34297 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 2.4), thyroid (RPKM 0.8) and 14 other tissues See more Orthologs mouse all
TTC36, Official Symbol TTC36provided by HGNC Official Full Name tetratricopeptide repeat domain 36provided by HGNC Primary source HGNC:HGNC:33708 See related Ensembl:ENSG00000172425 AllianceGenome:HGNC:33708 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBP21 Summary The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016] Expression Biased expression in liver (RPKM 51.1), kidney (RPKM 9.2) and 2 other tissues See more Orthologs mouse all
TTC38, Official Symbol TTC38provided by HGNC Official Full Name tetratricopeptide repeat domain 38provided by HGNC Primary source HGNC:HGNC:26082 See related Ensembl:ENSG00000075234 AllianceGenome:HGNC:26082 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LL22NC03-5H6.5 Summary Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 26.4), small intestine (RPKM 22.0) and 25 other tissues See more Orthologs mouse all
TTC39A, Official Symbol TTC39Aprovided by HGNC Official Full Name tetratricopeptide repeat domain 39Aprovided by HGNC Primary source HGNC:HGNC:18657 See related Ensembl:ENSG00000085831 MIM:619885; AllianceGenome:HGNC:18657 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEME-6; C1orf34 Summary Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 15.4), colon (RPKM 9.3) and 14 other tissues See more Orthologs mouse all
TTC39A-AS1, Official Symbol TTC39A-AS1provided by HGNC Official Full Name TTC39A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40851 See related Ensembl:ENSG00000261664 AllianceGenome:HGNC:40851 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable chromatin binding activity; ribonucleoprotein complex binding activity; and transcription cis-regulatory region binding activity. Predicted to act upstream of or within with a negative effect on inflammatory response and transcription by RNA polymerase II. Predicted to act upstream of or within gene expression; nucleosome organization; and response to lipopolysaccharide. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
TTC39B, Official Symbol TTC39Bprovided by HGNC Official Full Name tetratricopeptide repeat domain 39Bprovided by HGNC Primary source HGNC:HGNC:23704 See related Ensembl:ENSG00000155158 MIM:613574; AllianceGenome:HGNC:23704 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C9orf52 Summary Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of cholesterol storage; and regulation of cholesterol efflux. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 3.7), gall bladder (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
TTC39C, Official Symbol TTC39Cprovided by HGNC Official Full Name tetratricopeptide repeat domain 39Cprovided by HGNC Primary source HGNC:HGNC:26595 See related Ensembl:ENSG00000168234 AllianceGenome:HGNC:26595 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HsT2697; C18orf17 Summary Predicted to be involved in cilium assembly and otolith morphogenesis. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in liver (RPKM 7.1), skin (RPKM 3.6) and 20 other tissues See more Orthologs mouse all
TTC39C-AS1, Official Symbol TTC39C-AS1provided by HGNC Official Full Name TTC39C antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51321 See related Ensembl:ENSG00000264745 AllianceGenome:HGNC:51321 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 1.2), urinary bladder (RPKM 0.4) and 15 other tissues See more
TTC39CP1, Official Symbol TTC39CP1provided by HGNC Official Full Name tetratricopeptide repeat domain 39C pseudogene 1provided by HGNC Primary source HGNC:HGNC:44019 See related Ensembl:ENSG00000250627 AllianceGenome:HGNC:44019 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TTC39DP, Official Symbol TTC39DPprovided by HGNC Official Full Name tetratricopeptide repeat domain 39D, pseudogeneprovided by HGNC Primary source HGNC:HGNC:35451 See related Ensembl:ENSG00000227238 AllianceGenome:HGNC:35451 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TTC4, Official Symbol TTC4provided by HGNC Official Full Name tetratricopeptide repeat domain 4provided by HGNC Primary source HGNC:HGNC:12394 See related Ensembl:ENSG00000243725 MIM:606753; AllianceGenome:HGNC:12394 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNS1 Summary This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014] Expression Ubiquitous expression in testis (RPKM 12.6), ovary (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
TTC41P, Official Symbol TTC41Pprovided by HGNC Official Full Name tetratricopeptide repeat domain 41, pseudogeneprovided by HGNC Primary source HGNC:HGNC:49210 See related Ensembl:ENSG00000214198 AllianceGenome:HGNC:49210 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GNN; GNNP Summary Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 1.4), thyroid (RPKM 0.5) and 20 other tissues See more
TTC4P1, Official Symbol TTC4P1provided by HGNC Official Full Name tetratricopeptide repeat domain 4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:12395 See related Ensembl:ENSG00000221971 AllianceGenome:HGNC:12395 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTC4P
TTC5, Official Symbol TTC5provided by HGNC Official Full Name tetratricopeptide repeat domain 5provided by HGNC Primary source HGNC:HGNC:19274 See related Ensembl:ENSG00000136319 MIM:619014; AllianceGenome:HGNC:19274 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Strap; NEDCAFD Summary Predicted to enable DNA binding activity and chromatin binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
TTC6, Official Symbol TTC6provided by HGNC Official Full Name tetratricopeptide repeat domain 6provided by HGNC Primary source HGNC:HGNC:19739 See related Ensembl:ENSG00000139865 AllianceGenome:HGNC:19739 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C14orf25; NCRNA00291 Expression Biased expression in prostate (RPKM 2.5), testis (RPKM 2.0) and 3 other tissues See more Orthologs mouse all
TTC7A, Official Symbol TTC7Aprovided by HGNC Official Full Name tetratricopeptide repeat domain 7Aprovided by HGNC Primary source HGNC:HGNC:19750 See related Ensembl:ENSG00000068724 MIM:609332; AllianceGenome:HGNC:19750 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTC7; GIDID; MINAT Summary This gene encodes a protein containing tetratricopeptide repeats. Mutations in this gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Broad expression in testis (RPKM 14.8), bone marrow (RPKM 7.9) and 25 other tissues See more Orthologs mouse all
TTC7B, Official Symbol TTC7Bprovided by HGNC Official Full Name tetratricopeptide repeat domain 7Bprovided by HGNC Primary source HGNC:HGNC:19858 See related Ensembl:ENSG00000165914 MIM:620060; AllianceGenome:HGNC:19858 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTC7L1; c14_5685 Summary Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 16.7), fat (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
TTC8, Official Symbol TTC8provided by HGNC Official Full Name tetratricopeptide repeat domain 8provided by HGNC Primary source HGNC:HGNC:20087 See related Ensembl:ENSG00000165533 MIM:608132; AllianceGenome:HGNC:20087 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BBS8; RP51 Summary This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. A mutation in this gene has also been implicated in nonsyndromic retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Broad expression in ovary (RPKM 24.2), adrenal (RPKM 16.1) and 24 other tissues See more Orthologs mouse all
TTC9, Official Symbol TTC9provided by HGNC Official Full Name tetratricopeptide repeat domain 9provided by HGNC Primary source HGNC:HGNC:20267 See related Ensembl:ENSG00000133985 MIM:610488; AllianceGenome:HGNC:20267 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTC9A Summary This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Mar 2009] Expression Biased expression in esophagus (RPKM 24.9), brain (RPKM 6.0) and 11 other tissues See more Orthologs mouse all
TTC9B, Official Symbol TTC9Bprovided by HGNC Official Full Name tetratricopeptide repeat domain 9Bprovided by HGNC Primary source HGNC:HGNC:26395 See related Ensembl:ENSG00000174521 AllianceGenome:HGNC:26395 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in brain (RPKM 12.1) and adrenal (RPKM 0.2) See more Orthologs mouse all
TTC9C, Official Symbol TTC9Cprovided by HGNC Official Full Name tetratricopeptide repeat domain 9Cprovided by HGNC Primary source HGNC:HGNC:28432 See related Ensembl:ENSG00000162222 AllianceGenome:HGNC:28432 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in lymph node (RPKM 5.7), ovary (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
TTF1, Official Symbol TTF1provided by HGNC Official Full Name transcription termination factor 1provided by HGNC Primary source HGNC:HGNC:12397 See related Ensembl:ENSG00000125482 MIM:600777; AllianceGenome:HGNC:12397 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTF-1; TTF-I Summary This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] Annotation information Note: TTF1 (GeneID 7270) and NKX2-1 (GeneID 7080) loci share the TTF1 symbol/alias in common. TTF1 is a widely used alternative name for thyroid transcription factor 1 (NKX2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (TTF1). [13 Feb 2013] Expression Ubiquitous expression in thyroid (RPKM 5.3), testis (RPKM 4.8) and 25 other tissues See more Orthologs mouse all
TTF2, Official Symbol TTF2provided by HGNC Official Full Name transcription termination factor 2provided by HGNC Primary source HGNC:HGNC:12398 See related Ensembl:ENSG00000116830 MIM:604718; AllianceGenome:HGNC:12398 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as F2; HuF2; ZGRF6 Summary This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008] Annotation information Note: TTF2 (Gene ID: 8458) and FOXE1 (Gene ID: 2304) share the TTF2 symbol/alias in common. TTF2 is a widely used alternative name for forkhead box E1 (FOXE1), which can be confused with the official symbol for transcription termination factor 2 (TTF2). [31 May 2018] Expression Ubiquitous expression in lymph node (RPKM 3.1), appendix (RPKM 2.5) and 25 other tissues See more Orthologs mouse all
TTI1, Official Symbol TTI1provided by HGNC Official Full Name TELO2 interacting protein 1provided by HGNC Primary source HGNC:HGNC:29029 See related Ensembl:ENSG00000101407 MIM:614425; AllianceGenome:HGNC:29029 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEDMIM; smg-10; KIAA0406 Summary Involved in regulation of TOR signaling. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
TTI2, Official Symbol TTI2provided by HGNC Official Full Name TELO2 interacting protein 2provided by HGNC Primary source HGNC:HGNC:26262 See related Ensembl:ENSG00000129696 MIM:614426; AllianceGenome:HGNC:26262 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT39; C8orf41 Summary This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013] Expression Ubiquitous expression in testis (RPKM 6.8), lymph node (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
TTK, Official Symbol TTKprovided by HGNC Official Full Name TTK protein kinaseprovided by HGNC Primary source HGNC:HGNC:12401 See related Ensembl:ENSG00000112742 MIM:604092; AllianceGenome:HGNC:12401 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESK; PYT; CT96; MPH1; MPS1; MPS1L1 Summary This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] Expression Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues See more Orthologs mouse all
TTL, Official Symbol TTLprovided by HGNC Official Full Name tubulin tyrosine ligaseprovided by HGNC Primary source HGNC:HGNC:21586 See related Ensembl:ENSG00000114999 MIM:608291; AllianceGenome:HGNC:21586 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in brain (RPKM 13.3), lung (RPKM 7.4) and 24 other tissues See more Orthologs mouse all