psui3905/ncbi_genes_summary huggingface dataset:
TNPO1P1, Official Symbol TNPO1P1provided by HGNC Official Full Name transportin 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:45120 See related Ensembl:ENSG00000225423 AllianceGenome:HGNC:45120 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TNPO1P2, Official Symbol TNPO1P2provided by HGNC Official Full Name transportin 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:45121 See related Ensembl:ENSG00000230662 AllianceGenome:HGNC:45121 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TNPO1P3, Official Symbol TNPO1P3provided by HGNC Official Full Name transportin 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:50718 See related Ensembl:ENSG00000229586 AllianceGenome:HGNC:50718 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TNPO2, Official Symbol TNPO2provided by HGNC Official Full Name transportin 2provided by HGNC Primary source HGNC:HGNC:19998 See related Ensembl:ENSG00000105576 MIM:603002; AllianceGenome:HGNC:19998 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPO3; TRN2; KPNB2B; IDDHISD Summary Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within negative regulation of muscle cell differentiation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 25.6), testis (RPKM 20.6) and 25 other tissues See more Orthologs mouse all
TNPO3, Official Symbol TNPO3provided by HGNC Official Full Name transportin 3provided by HGNC Primary source HGNC:HGNC:17103 See related Ensembl:ENSG00000064419 MIM:610032; AllianceGenome:HGNC:17103 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPO12; TRNSR; LGMD1F; LGMDD2; MTR10A; TRN-SR; TRN-SR2 Summary The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020] Expression Ubiquitous expression in testis (RPKM 16.7), thyroid (RPKM 13.7) and 25 other tissues See more Orthologs mouse all
TNPO3P1, Official Symbol TNPO3P1provided by HGNC Official Full Name TNPO3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:55053 See related Ensembl:ENSG00000271686 AllianceGenome:HGNC:55053 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TNR, Official Symbol TNRprovided by HGNC Official Full Name tenascin Rprovided by HGNC Primary source HGNC:HGNC:11953 See related Ensembl:ENSG00000116147 MIM:601995; AllianceGenome:HGNC:11953 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TN-R; NEDSTO Summary This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013] Expression Restricted expression toward brain (RPKM 22.5) See more Orthologs mouse all
TNR-IT1, Official Symbol TNR-IT1provided by HGNC Official Full Name TNR intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41391 See related AllianceGenome:HGNC:41391 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
TNRC18, Official Symbol TNRC18provided by HGNC Official Full Name trinucleotide repeat containing 18provided by HGNC Primary source HGNC:HGNC:11962 See related Ensembl:ENSG00000182095 AllianceGenome:HGNC:11962 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAGL79; TNRC18A Summary Predicted to enable chromatin binding activity. Located in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 6.4), colon (RPKM 6.2) and 25 other tissues See more Orthologs mouse all
TNRC18P2, Official Symbol TNRC18P2provided by HGNC Official Full Name trinucleotide repeat containing 18 pseudogene 2provided by HGNC Primary source HGNC:HGNC:34014 See related Ensembl:ENSG00000223566 AllianceGenome:HGNC:34014 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNRC18; TNRC18B
TNRC6A, Official Symbol TNRC6Aprovided by HGNC Official Full Name trinucleotide repeat containing adaptor 6Aprovided by HGNC Primary source HGNC:HGNC:11969 See related Ensembl:ENSG00000090905 MIM:610739; AllianceGenome:HGNC:11969 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GW1; FAME6; GW182; TNRC6; CAGH26 Summary This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 11.5), endometrium (RPKM 10.0) and 25 other tissues See more Orthologs mouse all
TNRC6B, Official Symbol TNRC6Bprovided by HGNC Official Full Name trinucleotide repeat containing adaptor 6Bprovided by HGNC Primary source HGNC:HGNC:29190 See related Ensembl:ENSG00000100354 MIM:610740; AllianceGenome:HGNC:29190 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDSBA Summary Enables RNA binding activity. Involved in regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 3.9), thyroid (RPKM 2.3) and 25 other tissues See more Orthologs mouse all
TNRC6B-DT, Official Symbol TNRC6B-DTprovided by HGNC Official Full Name TNRC6B divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55373 See related Ensembl:ENSG00000261202 AllianceGenome:HGNC:55373 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TNRC6C, Official Symbol TNRC6Cprovided by HGNC Official Full Name trinucleotide repeat containing adaptor 6Cprovided by HGNC Primary source HGNC:HGNC:29318 See related Ensembl:ENSG00000078687 MIM:610741; AllianceGenome:HGNC:29318 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable RNA binding activity. Involved in gene silencing by miRNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 4.2), testis (RPKM 3.1) and 25 other tissues See more Orthologs mouse all
TNS1, Official Symbol TNS1provided by HGNC Official Full Name tensin 1provided by HGNC Primary source HGNC:HGNC:11973 See related Ensembl:ENSG00000079308 MIM:600076; AllianceGenome:HGNC:11973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155 Summary The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] Expression Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues See more Orthologs mouse all
TNS1-AS1, Official Symbol TNS1-AS1provided by HGNC Official Full Name TNS1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40589 See related Ensembl:ENSG00000223923 AllianceGenome:HGNC:40589 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in ovary (RPKM 2.6), fat (RPKM 1.4) and 19 other tissues See more
TNS2, Official Symbol TNS2provided by HGNC Official Full Name tensin 2provided by HGNC Primary source HGNC:HGNC:19737 See related Ensembl:ENSG00000111077 MIM:607717; AllianceGenome:HGNC:19737 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1TEN; TENC1; C1-TEN Summary The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 68.0), ovary (RPKM 31.0) and 23 other tissues See more Orthologs mouse all
TNS3, Official Symbol TNS3provided by HGNC Official Full Name tensin 3provided by HGNC Primary source HGNC:HGNC:21616 See related Ensembl:ENSG00000136205 MIM:606825; AllianceGenome:HGNC:21616 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEM6; TENS1 Summary Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation and intracellular signal transduction. Predicted to act upstream of or within cell migration; lung alveolus development; and positive regulation of cell population proliferation. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 15.0), lung (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
TNS4, Official Symbol TNS4provided by HGNC Official Full Name tensin 4provided by HGNC Primary source HGNC:HGNC:24352 See related Ensembl:ENSG00000131746 MIM:608385; AllianceGenome:HGNC:24352 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTEN; PP14434 Summary Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues See more Orthologs mouse all
TNXB, Official Symbol TNXBprovided by HGNC Official Full Name tenascin XBprovided by HGNC Primary source HGNC:HGNC:11976 See related Ensembl:ENSG00000168477 MIM:600985; AllianceGenome:HGNC:11976 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; VUR8; TNXB1; TNXB2; TNXBS; EDSCLL; EDSCLL1 Summary This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in adrenal (RPKM 35.5), fat (RPKM 21.3) and 17 other tissues See more Orthologs mouse all
TOB1, Official Symbol TOB1provided by HGNC Official Full Name transducer of ERBB2, 1provided by HGNC Primary source HGNC:HGNC:11979 See related Ensembl:ENSG00000141232 MIM:605523; AllianceGenome:HGNC:11979 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOB; TROB; APRO5; APRO6; PIG49; TROB1 Summary This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in adrenal (RPKM 113.0), thyroid (RPKM 46.6) and 25 other tissues See more Orthologs mouse all
TOB1-AS1, Official Symbol TOB1-AS1provided by HGNC Official Full Name TOB1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44340 See related Ensembl:ENSG00000229980 AllianceGenome:HGNC:44340 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 1.4), brain (RPKM 1.2) and 25 other tissues See more
TOB2, Official Symbol TOB2provided by HGNC Official Full Name transducer of ERBB2, 2provided by HGNC Primary source HGNC:HGNC:11980 See related Ensembl:ENSG00000183864 MIM:607396; AllianceGenome:HGNC:11980 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOB4; TOBL; APRO5; TROB2 Summary TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004] Expression Ubiquitous expression in fat (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues See more Orthologs mouse all
TOE1, Official Symbol TOE1provided by HGNC Official Full Name target of EGR1, exonucleaseprovided by HGNC Primary source HGNC:HGNC:15954 See related Ensembl:ENSG00000132773 MIM:613931; AllianceGenome:HGNC:15954 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCH7; TOE-1; hCaf1z Summary Enables poly(A)-specific ribonuclease activity and snRNA binding activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and snRNA 3'-end processing. Located in Cajal body and cytoplasm. Implicated in pontocerebellar hypoplasia type 7. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 7.9), bone marrow (RPKM 5.3) and 25 other tissues See more Orthologs mouse all
TOGARAM1, Official Symbol TOGARAM1provided by HGNC Official Full Name TOG array regulator of axonemal microtubules 1provided by HGNC Primary source HGNC:HGNC:19959 See related Ensembl:ENSG00000198718 MIM:617618; AllianceGenome:HGNC:19959 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JBTS37; FAM179B; KIAA0423 Summary Predicted to enable microtubule binding activity. Predicted to be involved in organelle assembly and positive regulation of microtubule polymerization. Predicted to be located in ciliary basal body. Predicted to be active in cilium and microtubule cytoskeleton. Predicted to colocalize with microtubule. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 6.9), brain (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
TOGARAM2, Official Symbol TOGARAM2provided by HGNC Official Full Name TOG array regulator of axonemal microtubules 2provided by HGNC Primary source HGNC:HGNC:33715 See related Ensembl:ENSG00000189350 AllianceGenome:HGNC:33715 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM179A Summary Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle assembly. Predicted to be active in cilium and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lung (RPKM 1.7), spleen (RPKM 1.2) and 19 other tissues See more Orthologs mouse all
TOLLIP, Official Symbol TOLLIPprovided by HGNC Official Full Name toll interacting proteinprovided by HGNC Primary source HGNC:HGNC:16476 See related Ensembl:ENSG00000078902 MIM:606277; AllianceGenome:HGNC:16476 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-1RAcPIP Summary This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in brain (RPKM 31.0), testis (RPKM 17.9) and 25 other tissues See more Orthologs mouse all
TOM1, Official Symbol TOM1provided by HGNC Official Full Name target of myb1 membrane trafficking proteinprovided by HGNC Primary source HGNC:HGNC:11982 See related Ensembl:ENSG00000100284 MIM:604700; AllianceGenome:HGNC:11982 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD85 Summary This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in bone marrow (RPKM 24.4), esophagus (RPKM 24.1) and 25 other tissues See more Orthologs mouse all
TOM1L1, Official Symbol TOM1L1provided by HGNC Official Full Name target of myb1 like 1 membrane trafficking proteinprovided by HGNC Primary source HGNC:HGNC:11983 See related Ensembl:ENSG00000141198 MIM:604701; AllianceGenome:HGNC:11983 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRCASM Summary Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in duodenum (RPKM 37.8), thyroid (RPKM 25.7) and 24 other tissues See more Orthologs mouse all
TOM1L2, Official Symbol TOM1L2provided by HGNC Official Full Name target of myb1 like 2 membrane trafficking proteinprovided by HGNC Primary source HGNC:HGNC:11984 See related Ensembl:ENSG00000175662 MIM:615519; AllianceGenome:HGNC:11984 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017] Expression Broad expression in heart (RPKM 43.2), brain (RPKM 27.4) and 23 other tissues See more Orthologs mouse all
TOMM20, Official Symbol TOMM20provided by HGNC Official Full Name translocase of outer mitochondrial membrane 20provided by HGNC Primary source HGNC:HGNC:20947 See related Ensembl:ENSG00000173726 MIM:601848; AllianceGenome:HGNC:20947 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAS20; MOM19; TOM20 Summary Enables protein-transporting ATPase activity and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 101.1), brain (RPKM 96.3) and 25 other tissues See more Orthologs mouse all
TOMM20L, Official Symbol TOMM20Lprovided by HGNC Official Full Name translocase of outer mitochondrial membrane 20 likeprovided by HGNC Primary source HGNC:HGNC:33752 See related Ensembl:ENSG00000196860 AllianceGenome:HGNC:33752 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNQ9438 Summary Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Predicted to be integral component of membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Predicted to be integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: July 18, 2008: Although this gene has been referred to as TIMM9, TIMM9 is a distinct locus, located in a head-head orientation to UNQ9438. [18 Jul 2008] Expression Broad expression in testis (RPKM 4.2), thyroid (RPKM 0.8) and 20 other tissues See more Orthologs mouse all
TOMM20P1, Official Symbol TOMM20P1provided by HGNC Official Full Name TOMM20 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50518 See related AllianceGenome:HGNC:50518 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM20P3, Official Symbol TOMM20P3provided by HGNC Official Full Name TOMM20 pseudogene 3provided by HGNC Primary source HGNC:HGNC:50520 See related Ensembl:ENSG00000263935 AllianceGenome:HGNC:50520 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM22, Official Symbol TOMM22provided by HGNC Official Full Name translocase of outer mitochondrial membrane 22provided by HGNC Primary source HGNC:HGNC:18002 See related Ensembl:ENSG00000100216 MIM:607046; AllianceGenome:HGNC:18002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 1C9-2; TOM22; MST065; MSTP065 Summary The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 24.2), kidney (RPKM 23.3) and 25 other tissues See more Orthologs mouse all
TOMM22P1, Official Symbol TOMM22P1provided by HGNC Official Full Name TOMM22 pseudogene 1provided by HGNC Primary source HGNC:HGNC:38736 See related Ensembl:ENSG00000237427 AllianceGenome:HGNC:38736 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM22P2, Official Symbol TOMM22P2provided by HGNC Official Full Name TOMM22 pseudogene 2provided by HGNC Primary source HGNC:HGNC:38737 See related Ensembl:ENSG00000232195 AllianceGenome:HGNC:38737 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM22P3, Official Symbol TOMM22P3provided by HGNC Official Full Name TOMM22 pseudogene 3provided by HGNC Primary source HGNC:HGNC:38739 See related AllianceGenome:HGNC:38739 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM22P4, Official Symbol TOMM22P4provided by HGNC Official Full Name TOMM22 pseudogene 4provided by HGNC Primary source HGNC:HGNC:38740 See related Ensembl:ENSG00000248396 AllianceGenome:HGNC:38740 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM22P5, Official Symbol TOMM22P5provided by HGNC Official Full Name TOMM22 pseudogene 5provided by HGNC Primary source HGNC:HGNC:38741 See related AllianceGenome:HGNC:38741 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM22P6, Official Symbol TOMM22P6provided by HGNC Official Full Name TOMM22 pseudogene 6provided by HGNC Primary source HGNC:HGNC:38742 See related Ensembl:ENSG00000241874 AllianceGenome:HGNC:38742 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TOMM34, Official Symbol TOMM34provided by HGNC Official Full Name translocase of outer mitochondrial membrane 34provided by HGNC Primary source HGNC:HGNC:15746 See related Ensembl:ENSG00000025772 MIM:616049; AllianceGenome:HGNC:15746 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOM34; URCC3; HTOM34P Summary The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 58.9), adrenal (RPKM 15.3) and 22 other tissues See more Orthologs mouse all
TOMM40, Official Symbol TOMM40provided by HGNC Official Full Name translocase of outer mitochondrial membrane 40provided by HGNC Primary source HGNC:HGNC:18001 See related Ensembl:ENSG00000130204 MIM:608061; AllianceGenome:HGNC:18001 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOM40; PEREC1; C19orf1; PER-EC1; D19S1177E Summary The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015] Expression Ubiquitous expression in colon (RPKM 13.7), esophagus (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
TOMM40L, Official Symbol TOMM40Lprovided by HGNC Official Full Name translocase of outer mitochondrial membrane 40 likeprovided by HGNC Primary source HGNC:HGNC:25756 See related Ensembl:ENSG00000158882 AllianceGenome:HGNC:25756 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOMM40B Summary Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 24 other tissues See more Orthologs mouse all
TOMM5, Official Symbol TOMM5provided by HGNC Official Full Name translocase of outer mitochondrial membrane 5provided by HGNC Primary source HGNC:HGNC:31369 See related Ensembl:ENSG00000175768 MIM:616169; AllianceGenome:HGNC:31369 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Tom5; C9orf105; bA613M10.3 Summary Predicted to be involved in protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 28.8), colon (RPKM 28.3) and 25 other tissues See more Orthologs mouse all
TOMM6, Official Symbol TOMM6provided by HGNC Official Full Name translocase of outer mitochondrial membrane 6provided by HGNC Primary source HGNC:HGNC:34528 See related Ensembl:ENSG00000214736 MIM:616168; AllianceGenome:HGNC:34528 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OBTP; TOM6 Summary Predicted to be involved in protein transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 63.4), kidney (RPKM 57.9) and 25 other tissues See more Orthologs mouse all
TOMM7, Official Symbol TOMM7provided by HGNC Official Full Name translocase of outer mitochondrial membrane 7provided by HGNC Primary source HGNC:HGNC:21648 See related Ensembl:ENSG00000196683 MIM:607980; AllianceGenome:HGNC:21648 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOM7 Summary This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in ovary (RPKM 141.3), fat (RPKM 120.2) and 25 other tissues See more Orthologs mouse all
TOMM70, Official Symbol TOMM70provided by HGNC Official Full Name translocase of outer mitochondrial membrane 70provided by HGNC Primary source HGNC:HGNC:11985 See related Ensembl:ENSG00000154174 MIM:606081; AllianceGenome:HGNC:11985 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Tom70; TOMM70A Summary This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Ubiquitous expression in brain (RPKM 23.1), thyroid (RPKM 20.6) and 25 other tissues See more Orthologs mouse all
TONSL, Official Symbol TONSLprovided by HGNC Official Full Name tonsoku like, DNA repair proteinprovided by HGNC Primary source HGNC:HGNC:7801 See related Ensembl:ENSG00000160949 MIM:604546; AllianceGenome:HGNC:7801 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IKBR; SEMDSP; NFKBIL2 Summary The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 3.5), small intestine (RPKM 2.3) and 24 other tissues See more Orthologs mouse all
TOP1, Official Symbol TOP1provided by HGNC Official Full Name DNA topoisomerase Iprovided by HGNC Primary source HGNC:HGNC:11986 See related Ensembl:ENSG00000198900 MIM:126420; AllianceGenome:HGNC:11986 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOPI Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 33.0), lymph node (RPKM 31.6) and 25 other tissues See more Orthologs mouse all
TOP1MT, Official Symbol TOP1MTprovided by HGNC Official Full Name DNA topoisomerase I mitochondrialprovided by HGNC Primary source HGNC:HGNC:29787 See related Ensembl:ENSG00000184428 MIM:606387; AllianceGenome:HGNC:29787 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] Expression Ubiquitous expression in ovary (RPKM 11.4), bone marrow (RPKM 11.1) and 25 other tissues See more Orthologs mouse all
TOP2A, Official Symbol TOP2Aprovided by HGNC Official Full Name DNA topoisomerase II alphaprovided by HGNC Primary source HGNC:HGNC:11989 See related Ensembl:ENSG00000131747 MIM:126430; AllianceGenome:HGNC:11989 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOP2; TP2A; TOPIIA; TOP2alpha Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] Expression Biased expression in testis (RPKM 34.8), lymph node (RPKM 21.9) and 13 other tissues See more Orthologs mouse all
TOP2B, Official Symbol TOP2Bprovided by HGNC Official Full Name DNA topoisomerase II betaprovided by HGNC Primary source HGNC:HGNC:11990 See related Ensembl:ENSG00000077097 MIM:126431; AllianceGenome:HGNC:11990 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BILU; TOPIIB; top2beta Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] Expression Ubiquitous expression in urinary bladder (RPKM 32.3), brain (RPKM 31.7) and 25 other tissues See more Orthologs mouse all
TOP3A, Official Symbol TOP3Aprovided by HGNC Official Full Name DNA topoisomerase III alphaprovided by HGNC Primary source HGNC:HGNC:11992 See related Ensembl:ENSG00000177302 MIM:601243; AllianceGenome:HGNC:11992 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOP3; PEOB5; ZGRF7; MGRISCE2 Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in testis (RPKM 4.1), bone marrow (RPKM 3.1) and 25 other tissues See more Orthologs mouse all
TOP3B, Official Symbol TOP3Bprovided by HGNC Official Full Name DNA topoisomerase III betaprovided by HGNC Primary source HGNC:HGNC:11993 See related Ensembl:ENSG00000100038 MIM:603582; AllianceGenome:HGNC:11993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOP3B1 Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in spleen (RPKM 4.6), lymph node (RPKM 3.7) and 25 other tissues See more Orthologs mouse all
TOPAZ1, Official Symbol TOPAZ1provided by HGNC Official Full Name testis and ovary specific TOPAZ 1provided by HGNC Primary source HGNC:HGNC:24746 See related Ensembl:ENSG00000173769 MIM:614412; AllianceGenome:HGNC:24746 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3orf77 Summary Predicted to be involved in spermatid development and spermatocyte division. Predicted to act upstream of or within apoptotic process; ncRNA transcription; and positive regulation of meiotic cell cycle phase transition. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 2.4) See more Orthologs mouse all
TOPBP1, Official Symbol TOPBP1provided by HGNC Official Full Name DNA topoisomerase II binding protein 1provided by HGNC Primary source HGNC:HGNC:17008 See related Ensembl:ENSG00000163781 MIM:607760; AllianceGenome:HGNC:17008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Dpb11; TOP2BP1 Summary This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 16.9), bone marrow (RPKM 13.6) and 25 other tissues See more Orthologs mouse all