psui3905/ncbi_genes_summary huggingface dataset:
PC, Official Symbol PCprovided by HGNC Official Full Name pyruvate carboxylaseprovided by HGNC Primary source HGNC:HGNC:8636 See related Ensembl:ENSG00000173599 MIM:608786; AllianceGenome:HGNC:8636 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCB Summary This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 30.0), liver (RPKM 19.3) and 13 other tissues See more Orthologs mouse all
PCA3, Official Symbol PCA3provided by HGNC Official Full Name prostate cancer associated 3provided by HGNC Primary source HGNC:HGNC:8637 See related Ensembl:ENSG00000225937 MIM:604845; AllianceGenome:HGNC:8637 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DD3; PCAT3; NCRNA00019; PRUNE2-AS1 Summary This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017] Expression Restricted expression toward prostate (RPKM 4.9) See more
PCARE, Official Symbol PCAREprovided by HGNC Official Full Name photoreceptor cilium actin regulatorprovided by HGNC Primary source HGNC:HGNC:34383 See related Ensembl:ENSG00000179270 MIM:613425; AllianceGenome:HGNC:34383 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP54; C2orf71 Summary The protein encoded by this gene is highly expressed in photoreceptors and may associate with the primary cilium of the outer segment. The encoded protein appears to undergo post-translational lipid modification. Nonsense and missense variants of this gene appear to cause a recessive form of retinitis pigmentosa. [provided by RefSeq, Jun 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
PCAT1, Official Symbol PCAT1provided by HGNC Official Full Name prostate cancer associated transcript 1provided by HGNC Primary source HGNC:HGNC:43022 See related Ensembl:ENSG00000253438 MIM:616043; AllianceGenome:HGNC:43022 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCA1; PiHL; PCAT-1 Summary This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways. [provided by RefSeq, Dec 2017] Expression Low expression observed in reference dataset See more
PCAT14, Official Symbol PCAT14provided by HGNC Official Full Name prostate cancer associated transcript 14provided by HGNC Primary source HGNC:HGNC:48977 See related AllianceGenome:HGNC:48977 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward prostate (RPKM 12.3) See more
PCAT18, Official Symbol PCAT18provided by HGNC Official Full Name prostate cancer associated transcript 18provided by HGNC Primary source HGNC:HGNC:49211 See related Ensembl:ENSG00000265369 MIM:617647; AllianceGenome:HGNC:49211 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01092 Expression Biased expression in prostate (RPKM 2.5), stomach (RPKM 1.5) and 4 other tissues See more
PCAT19, Official Symbol PCAT19provided by HGNC Official Full Name prostate cancer associated transcript 19provided by HGNC Primary source HGNC:HGNC:49593 See related Ensembl:ENSG00000267107 MIM:618192; AllianceGenome:HGNC:49593 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01190 Expression Broad expression in fat (RPKM 5.8), lung (RPKM 5.0) and 22 other tissues See more
PCAT4, Official Symbol PCAT4provided by HGNC Official Full Name prostate cancer associated transcript 4provided by HGNC Primary source HGNC:HGNC:24853 See related Ensembl:ENSG00000251321 MIM:609717; AllianceGenome:HGNC:24853 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDEP; PCA4; PCAN1 Expression Restricted expression toward prostate (RPKM 24.7) See more
PCAT5, Official Symbol PCAT5provided by HGNC Official Full Name prostate cancer associated transcript 5provided by HGNC Primary source HGNC:HGNC:48665 See related Ensembl:ENSG00000280719 AllianceGenome:HGNC:48665 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01452; TPCAT-10-36067 Expression Low expression observed in reference dataset See more
PCAT6, Official Symbol PCAT6provided by HGNC Official Full Name prostate cancer associated transcript 6provided by HGNC Primary source HGNC:HGNC:43714 See related Ensembl:ENSG00000228288 AllianceGenome:HGNC:43714 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCAN-R1; KDM5BAS1; ncRNA-a2; KDM5B-AS1; onco-lncRNA-96 Expression Biased expression in testis (RPKM 17.7), skin (RPKM 2.8) and 6 other tissues See more
PCAT7, Official Symbol PCAT7provided by HGNC Official Full Name prostate cancer associated transcript 7provided by HGNC Primary source HGNC:HGNC:48824 See related AllianceGenome:HGNC:48824 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCAN-R2 Expression Biased expression in stomach (RPKM 5.4), testis (RPKM 2.0) and 9 other tissues See more
PCBD1, Official Symbol PCBD1provided by HGNC Official Full Name pterin-4 alpha-carbinolamine dehydratase 1provided by HGNC Primary source HGNC:HGNC:8646 See related Ensembl:ENSG00000166228 MIM:126090; AllianceGenome:HGNC:8646 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCD; PHS; DCOH; PCBD Summary This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in liver (RPKM 47.7), kidney (RPKM 31.6) and 25 other tissues See more Orthologs mouse all
PCBD2, Official Symbol PCBD2provided by HGNC Official Full Name pterin-4 alpha-carbinolamine dehydratase 2provided by HGNC Primary source HGNC:HGNC:24474 See related Ensembl:ENSG00000132570 MIM:609836; AllianceGenome:HGNC:24474 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PHS2; DCOH2; DCOHM Summary Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Involved in positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 3.0), kidney (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
PCBP1, Official Symbol PCBP1provided by HGNC Official Full Name poly(rC) binding protein 1provided by HGNC Primary source HGNC:HGNC:8647 See related Ensembl:ENSG00000169564 MIM:601209; AllianceGenome:HGNC:8647 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1 Summary This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008] Orthologs mouse all
PCBP1-AS1, Official Symbol PCBP1-AS1provided by HGNC Official Full Name PCBP1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:42948 See related Ensembl:ENSG00000179818 AllianceGenome:HGNC:42948 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Linc-GALH Expression Ubiquitous expression in testis (RPKM 3.5), ovary (RPKM 2.9) and 24 other tissues See more
PCBP2, Official Symbol PCBP2provided by HGNC Official Full Name poly(rC) binding protein 2provided by HGNC Primary source HGNC:HGNC:8648 See related Ensembl:ENSG00000197111 MIM:601210; AllianceGenome:HGNC:8648 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HNRPE2; HNRNPE2; hnRNP-E2 Summary The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018] Expression Ubiquitous expression in kidney (RPKM 155.8), thyroid (RPKM 127.6) and 25 other tissues See more Orthologs mouse all
PCBP2-OT1, Official Symbol PCBP2-OT1provided by HGNC Official Full Name PCBP2 overlapping transcript 1provided by HGNC Primary source HGNC:HGNC:49150 See related Ensembl:ENSG00000282977 AllianceGenome:HGNC:49150 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TUC338; uc.338; TUC.338
PCBP3, Official Symbol PCBP3provided by HGNC Official Full Name poly(rC) binding protein 3provided by HGNC Primary source HGNC:HGNC:8651 See related Ensembl:ENSG00000183570 MIM:608502; AllianceGenome:HGNC:8651 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCBP3OT; ALPHA-CP3; PCBP3-OT1 Summary This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017] Expression Broad expression in testis (RPKM 8.3), endometrium (RPKM 4.4) and 17 other tissues See more Orthologs mouse all
PCBP4, Official Symbol PCBP4provided by HGNC Official Full Name poly(rC) binding protein 4provided by HGNC Primary source HGNC:HGNC:8652 See related Ensembl:ENSG00000090097 MIM:608503; AllianceGenome:HGNC:8652 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBP; LIP4; MCG10 Summary This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 22.5), prostate (RPKM 9.4) and 24 other tissues See more Orthologs mouse all
PCCA, Official Symbol PCCAprovided by HGNC Official Full Name propionyl-CoA carboxylase subunit alphaprovided by HGNC Primary source HGNC:HGNC:8653 See related Ensembl:ENSG00000175198 MIM:232000; AllianceGenome:HGNC:8653 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] Expression Broad expression in kidney (RPKM 11.9), liver (RPKM 5.1) and 23 other tissues See more Orthologs mouse all
PCCA-DT, Official Symbol PCCA-DTprovided by HGNC Official Full Name PCCA divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53266 See related Ensembl:ENSG00000274605 AllianceGenome:HGNC:53266 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in prostate (RPKM 5.0), liver (RPKM 1.9) and 23 other tissues See more
PCCB, Official Symbol PCCBprovided by HGNC Official Full Name propionyl-CoA carboxylase subunit betaprovided by HGNC Primary source HGNC:HGNC:8654 See related Ensembl:ENSG00000114054 MIM:232050; AllianceGenome:HGNC:8654 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] Expression Ubiquitous expression in liver (RPKM 38.7), kidney (RPKM 36.6) and 25 other tissues See more Orthologs mouse all
PCDH1, Official Symbol PCDH1provided by HGNC Official Full Name protocadherin 1provided by HGNC Primary source HGNC:HGNC:8655 See related Ensembl:ENSG00000156453 MIM:603626; AllianceGenome:HGNC:8655 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PC42; PCDH42 Summary This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 10.0), colon (RPKM 8.9) and 22 other tissues See more Orthologs mouse all
PCDH10, Official Symbol PCDH10provided by HGNC Official Full Name protocadherin 10provided by HGNC Primary source HGNC:HGNC:13404 See related Ensembl:ENSG00000138650 MIM:608286; AllianceGenome:HGNC:13404 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDH19; OL-PCDH Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] Expression Biased expression in brain (RPKM 21.3), placenta (RPKM 10.2) and 4 other tissues See more Orthologs mouse all
PCDH11X, Official Symbol PCDH11Xprovided by HGNC Official Full Name protocadherin 11 X-linkedprovided by HGNC Primary source HGNC:HGNC:8656 See related Ensembl:ENSG00000102290 MIM:300246; AllianceGenome:HGNC:8656 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDHX; PCDH-X; PCDH-Y; PCDH11; PCDH22; PCDH11Y; PPP1R119 Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Biased expression in ovary (RPKM 3.1), brain (RPKM 2.5) and 2 other tissues See more Orthologs mouse all
PCDH11Y, Official Symbol PCDH11Yprovided by HGNC Official Full Name protocadherin 11 Y-linkedprovided by HGNC Primary source HGNC:HGNC:15813 See related Ensembl:ENSG00000099715 MIM:400022; AllianceGenome:HGNC:15813 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDHX; PCDHY; PCDH22; PCDH-PC Summary This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] Expression Biased expression in brain (RPKM 1.4), ovary (RPKM 0.6) and 5 other tissues See more
PCDH12, Official Symbol PCDH12provided by HGNC Official Full Name protocadherin 12provided by HGNC Primary source HGNC:HGNC:8657 See related Ensembl:ENSG00000113555 MIM:605622; AllianceGenome:HGNC:8657 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DMJDS1; VECAD2; VE-cadherin-2 Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 15.3), lung (RPKM 10.9) and 20 other tissues See more Orthologs mouse all
PCDH15, Official Symbol PCDH15provided by HGNC Official Full Name protocadherin related 15provided by HGNC Primary source HGNC:HGNC:14674 See related Ensembl:ENSG00000150275 MIM:605514; AllianceGenome:HGNC:14674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USH1F; CDHR15; DFNB23 Summary This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008] Expression Biased expression in brain (RPKM 1.2), adrenal (RPKM 0.8) and 5 other tissues See more Orthologs mouse all
PCDH17, Official Symbol PCDH17provided by HGNC Official Full Name protocadherin 17provided by HGNC Primary source HGNC:HGNC:14267 See related Ensembl:ENSG00000118946 MIM:611760; AllianceGenome:HGNC:14267 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCH68; PCDH68 Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 10.8), brain (RPKM 7.3) and 14 other tissues See more Orthologs mouse all
PCDH18, Official Symbol PCDH18provided by HGNC Official Full Name protocadherin 18provided by HGNC Primary source HGNC:HGNC:14268 See related Ensembl:ENSG00000189184 MIM:608287; AllianceGenome:HGNC:14268 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDH68L Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 18.1), endometrium (RPKM 17.7) and 21 other tissues See more Orthologs mouse all
PCDH19, Official Symbol PCDH19provided by HGNC Official Full Name protocadherin 19provided by HGNC Primary source HGNC:HGNC:14270 See related Ensembl:ENSG00000165194 MIM:300460; AllianceGenome:HGNC:14270 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE9; EFMR; EIEE9 Summary The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Mutations in this gene on human chromosome X are associated with sporadic infantile epileptic encephalopathy and to a female-restricted form of epilepsy (EFMR; also known as PCDH19RE). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017] Expression Biased expression in brain (RPKM 4.4), fat (RPKM 1.2) and 8 other tissues See more Orthologs mouse all
PCDH20, Official Symbol PCDH20provided by HGNC Official Full Name protocadherin 20provided by HGNC Primary source HGNC:HGNC:14257 See related Ensembl:ENSG00000280165 MIM:614449; AllianceGenome:HGNC:14257 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDH13 Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 4.5), lung (RPKM 1.5) and 14 other tissues See more Orthologs mouse all
PCDH7, Official Symbol PCDH7provided by HGNC Official Full Name protocadherin 7provided by HGNC Primary source HGNC:HGNC:8659 See related Ensembl:ENSG00000169851 MIM:602988; AllianceGenome:HGNC:8659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BHPCDH; BH-Pcdh; PPP1R120 Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 10.8), spleen (RPKM 5.9) and 17 other tissues See more Orthologs mouse all
PCDH8, Official Symbol PCDH8provided by HGNC Official Full Name protocadherin 8provided by HGNC Primary source HGNC:HGNC:8660 See related Ensembl:ENSG00000136099 MIM:603580; AllianceGenome:HGNC:8660 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAPC; ARCADLIN Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 2.9), testis (RPKM 0.5) and 2 other tissues See more Orthologs mouse all
PCDH8P1, Official Symbol PCDH8P1provided by HGNC Official Full Name protocadherin 8 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39937 See related AllianceGenome:HGNC:39937 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PCDH9, Official Symbol PCDH9provided by HGNC Official Full Name protocadherin 9provided by HGNC Primary source HGNC:HGNC:8661 See related Ensembl:ENSG00000184226 MIM:603581; AllianceGenome:HGNC:8661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2012] Expression Biased expression in brain (RPKM 8.9), fat (RPKM 0.9) and 2 other tissues See more Orthologs mouse all
PCDH9-AS2, Official Symbol PCDH9-AS2provided by HGNC Official Full Name PCDH9 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:39896 See related Ensembl:ENSG00000228842 AllianceGenome:HGNC:39896 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PCDH9-AS3, Official Symbol PCDH9-AS3provided by HGNC Official Full Name PCDH9 antisense RNA 3provided by HGNC Primary source HGNC:HGNC:40427 See related Ensembl:ENSG00000225263 AllianceGenome:HGNC:40427 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.1) See more
PCDH9-AS4, Official Symbol PCDH9-AS4provided by HGNC Official Full Name PCDH9 antisense RNA 4provided by HGNC Primary source HGNC:HGNC:40428 See related Ensembl:ENSG00000233840 AllianceGenome:HGNC:40428 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PCDHA1, Official Symbol PCDHA1provided by HGNC Official Full Name protocadherin alpha 1provided by HGNC Primary source HGNC:HGNC:8663 See related Ensembl:ENSG00000204970 MIM:606307; AllianceGenome:HGNC:8663 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDH-ALPHA1 Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Orthologs mouse all
PCDHA10, Official Symbol PCDHA10provided by HGNC Official Full Name protocadherin alpha 10provided by HGNC Primary source HGNC:HGNC:8664 See related Ensembl:ENSG00000250120 MIM:606316; AllianceGenome:HGNC:8664 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNR8; CNRN8; CNRS8; CRNR8; PCDH-ALPHA10 Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Orthologs mouse all
PCDHA11, Official Symbol PCDHA11provided by HGNC Official Full Name protocadherin alpha 11provided by HGNC Primary source HGNC:HGNC:8665 See related Ensembl:ENSG00000249158 MIM:606317; AllianceGenome:HGNC:8665 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNR7; CNRN7; CNRS7; CRNR7; PCDH-ALPHA11 Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Orthologs mouse all
PCDHA12, Official Symbol PCDHA12provided by HGNC Official Full Name protocadherin alpha 12provided by HGNC Primary source HGNC:HGNC:8666 See related Ensembl:ENSG00000251664 MIM:606318; AllianceGenome:HGNC:8666 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDH-ALPHA12 Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Orthologs mouse all
PCDHA13, Official Symbol PCDHA13provided by HGNC Official Full Name protocadherin alpha 13provided by HGNC Primary source HGNC:HGNC:8667 See related Ensembl:ENSG00000239389 MIM:606319; AllianceGenome:HGNC:8667 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CNR5; CNRN5; CNRS5; CRNR5; PCDH-ALPHA13 Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Orthologs all
PCDHA2, Official Symbol PCDHA2provided by HGNC Official Full Name protocadherin alpha 2provided by HGNC Primary source HGNC:HGNC:8668 See related Ensembl:ENSG00000204969 MIM:606308; AllianceGenome:HGNC:8668 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDH-ALPHA2 Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Orthologs mouse all
PCDHA3, Official Symbol PCDHA3provided by HGNC Official Full Name protocadherin alpha 3provided by HGNC Primary source HGNC:HGNC:8669 See related Ensembl:ENSG00000255408 MIM:606309; AllianceGenome:HGNC:8669 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCDH-ALPHA3 Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] Orthologs mouse all