psui3905/ncbi_genes_summary huggingface dataset:
ZFAND5, Official Symbol ZFAND5provided by HGNC Official Full Name zinc finger AN1-type containing 5provided by HGNC Primary source HGNC:HGNC:13008 See related Ensembl:ENSG00000107372 MIM:604761; AllianceGenome:HGNC:13008 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZA20D2; ZNF216; ZFAND5A Summary Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to act upstream of or within several processes, including face development; fibroblast migration; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 113.8), adrenal (RPKM 84.6) and 25 other tissues See more Orthologs mouse all
ZFAND6, Official Symbol ZFAND6provided by HGNC Official Full Name zinc finger AN1-type containing 6provided by HGNC Primary source HGNC:HGNC:30164 See related Ensembl:ENSG00000086666 MIM:610183; AllianceGenome:HGNC:30164 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AWP1; ZA20D3; ZFAND5B Summary Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 50.8), thyroid (RPKM 41.4) and 25 other tissues See more Orthologs mouse all
ZFAND6P1, Official Symbol ZFAND6P1provided by HGNC Official Full Name zinc finger AN1-type containing 6 pseudogene 1provided by HGNC Primary source HGNC:HGNC:42978 See related AllianceGenome:HGNC:42978 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZFAS1, Official Symbol ZFAS1provided by HGNC Official Full Name ZNFX1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:33101 See related Ensembl:ENSG00000177410 AllianceGenome:HGNC:33101 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSUP1; HSUP2; C20orf199; ZNFX1-AS1; NCRNA00275 Summary This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017] Expression Ubiquitous expression in ovary (RPKM 66.8), bone marrow (RPKM 54.6) and 24 other tissues See more
ZFAT, Official Symbol ZFATprovided by HGNC Official Full Name zinc finger and AT-hook domain containingprovided by HGNC Primary source HGNC:HGNC:19899 See related Ensembl:ENSG00000066827 MIM:610931; AllianceGenome:HGNC:19899 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AITD3; ZFAT1; ZNF406 Summary This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009] Expression Broad expression in placenta (RPKM 4.4), kidney (RPKM 1.1) and 17 other tissues See more Orthologs mouse all
ZFAT-AS1, Official Symbol ZFAT-AS1provided by HGNC Official Full Name ZFAT antisense RNA 1provided by HGNC Primary source HGNC:HGNC:33992 See related Ensembl:ENSG00000248492 AllianceGenome:HGNC:33992 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFATAS; ZFAT-AS; SAS-ZFAT; NCRNA00070 Summary This gene encodes a small antisense RNA that may be involved in regulating the sense strand locus, zinc finger and AT hook domain containing. This RNA may play a role in B cell function. A single nucleotide polymorphism in the promoter of this gene is associated with an increased risk of autoimmune thyroid disease.[provided by RefSeq, Jan 2010] Expression Broad expression in placenta (RPKM 6.9), kidney (RPKM 2.4) and 18 other tissues See more
ZFC3H1, Official Symbol ZFC3H1provided by HGNC Official Full Name zinc finger C3H1-type containingprovided by HGNC Primary source HGNC:HGNC:28328 See related Ensembl:ENSG00000133858 AllianceGenome:HGNC:28328 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSRC2; PSRC2; CCDC131 Summary Predicted to enable metal ion binding activity. Predicted to be involved in RNA processing. Located in nucleus. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 12.9), testis (RPKM 11.4) and 25 other tissues See more Orthologs mouse all
ZFHX2, Official Symbol ZFHX2provided by HGNC Official Full Name zinc finger homeobox 2provided by HGNC Primary source HGNC:HGNC:20152 See related Ensembl:ENSG00000136367 MIM:617828; AllianceGenome:HGNC:20152 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFH5; ZFH-5; MARSIS; ZNF409 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of sensory perception of pain. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 3.0), brain (RPKM 0.7) and 5 other tissues See more Orthologs mouse all
ZFHX3, Official Symbol ZFHX3provided by HGNC Official Full Name zinc finger homeobox 3provided by HGNC Primary source HGNC:HGNC:777 See related Ensembl:ENSG00000140836 MIM:104155; AllianceGenome:HGNC:777 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATBT; ATBF1; ZFH-3; ZNF927; C16orf47 Summary This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in thyroid (RPKM 3.0), prostate (RPKM 2.4) and 25 other tissues See more Orthologs mouse all
ZFHX4, Official Symbol ZFHX4provided by HGNC Official Full Name zinc finger homeobox 4provided by HGNC Primary source HGNC:HGNC:30939 See related Ensembl:ENSG00000091656 MIM:606940; AllianceGenome:HGNC:30939 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFH4; ZHF4 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 2.1), adrenal (RPKM 2.1) and 16 other tissues See more Orthologs mouse all
ZFHX4-AS1, Official Symbol ZFHX4-AS1provided by HGNC Official Full Name ZFHX4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44165 See related Ensembl:ENSG00000253661 AllianceGenome:HGNC:44165 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in brain (RPKM 1.6), fat (RPKM 1.1) and 6 other tissues See more
ZFP1, Official Symbol ZFP1provided by HGNC Official Full Name ZFP1 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:23328 See related Ensembl:ENSG00000184517 MIM:617230; AllianceGenome:HGNC:23328 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF475 Summary This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.0) and 24 other tissues See more Orthologs mouse all
ZFP14, Official Symbol ZFP14provided by HGNC Official Full Name ZFP14 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:29312 See related Ensembl:ENSG00000142065 MIM:620163; AllianceGenome:HGNC:29312 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF531 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within blastocyst hatching. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 2.2), endometrium (RPKM 1.7) and 25 other tissues See more Orthologs mouse all
ZFP2, Official Symbol ZFP2provided by HGNC Official Full Name ZFP2 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:26138 See related Ensembl:ENSG00000198939 AllianceGenome:HGNC:26138 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as zfp-2; ZNF751 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 2.5), ovary (RPKM 1.7) and 24 other tissues See more Orthologs mouse all
ZFP28, Official Symbol ZFP28provided by HGNC Official Full Name ZFP28 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:17801 See related Ensembl:ENSG00000196867 MIM:616798; AllianceGenome:HGNC:17801 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as mkr5 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 2.5), brain (RPKM 2.0) and 24 other tissues See more Orthologs mouse all
ZFP28-DT, Official Symbol ZFP28-DTprovided by HGNC Official Full Name ZFP28 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55297 See related AllianceGenome:HGNC:55297 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ZFP3, Official Symbol ZFP3provided by HGNC Official Full Name ZFP3 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:12861 See related Ensembl:ENSG00000180787 MIM:194480; AllianceGenome:HGNC:12861 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF752 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 4.0), duodenum (RPKM 3.8) and 24 other tissues See more Orthologs mouse all
ZFP30, Official Symbol ZFP30provided by HGNC Official Full Name ZFP30 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:29555 See related Ensembl:ENSG00000120784 MIM:617317; AllianceGenome:HGNC:29555 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF745 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.4) and 25 other tissues See more Orthologs all
ZFP36, Official Symbol ZFP36provided by HGNC Official Full Name ZFP36 ring finger proteinprovided by HGNC Primary source HGNC:HGNC:12862 See related Ensembl:ENSG00000128016 MIM:190700; AllianceGenome:HGNC:12862 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A Summary Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Colocalizes with RISC-loading complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 274.6), bone marrow (RPKM 248.5) and 25 other tissues See more Orthologs mouse all
ZFP36L1, Official Symbol ZFP36L1provided by HGNC Official Full Name ZFP36 ring finger protein like 1provided by HGNC Primary source HGNC:HGNC:1107 See related Ensembl:ENSG00000185650 MIM:601064; AllianceGenome:HGNC:1107 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B Summary This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in endometrium (RPKM 164.2), ovary (RPKM 123.6) and 25 other tissues See more Orthologs mouse all
ZFP36L2, Official Symbol ZFP36L2provided by HGNC Official Full Name ZFP36 ring finger protein like 2provided by HGNC Primary source HGNC:HGNC:1108 See related Ensembl:ENSG00000152518 MIM:612053; AllianceGenome:HGNC:1108 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRF2; ERF2; ERF-2; OOMD13; TIS11D; OZEMA13; RNF162C Summary This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 108.0), appendix (RPKM 94.7) and 25 other tissues See more Orthologs mouse all
ZFP37, Official Symbol ZFP37provided by HGNC Official Full Name ZFP37 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:12863 See related Ensembl:ENSG00000136866 MIM:602951; AllianceGenome:HGNC:12863 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF906; zfp-37 Summary This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.7) and 21 other tissues See more Orthologs mouse all
ZFP41, Official Symbol ZFP41provided by HGNC Official Full Name ZFP41 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:26786 See related Ensembl:ENSG00000181638 AllianceGenome:HGNC:26786 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF753; zfp-41 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.9), ovary (RPKM 2.1) and 25 other tissues See more Orthologs mouse all
ZFP42, Official Symbol ZFP42provided by HGNC Official Full Name ZFP42 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:30949 See related Ensembl:ENSG00000179059 MIM:614572; AllianceGenome:HGNC:30949 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as REX1; REX-1; ZNF754; zfp-42 Summary Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 1.0), placenta (RPKM 0.5) and 1 other tissue See more Orthologs mouse all
ZFP57, Official Symbol ZFP57provided by HGNC Official Full Name ZFP57 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:18791 See related Ensembl:ENSG00000204644 MIM:612192; AllianceGenome:HGNC:18791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNDM1; ZNF698; C6orf40; bA145L22; bA145L22.2 Summary The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009] Expression Biased expression in heart (RPKM 2.7), brain (RPKM 1.0) and 13 other tissues See more Orthologs mouse all
ZFP62, Official Symbol ZFP62provided by HGNC Official Full Name ZFP62 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:23241 See related Ensembl:ENSG00000196670 MIM:610281; AllianceGenome:HGNC:23241 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZET; ZNF755 Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: Annotation of ZFP62 was placed on AC016572.6 on NCBI's annotation 36.3. This clone has been determined to be redundant, so the annotation was merged with the location on the assembled chromosome. [02 Mar 2009] Expression Ubiquitous expression in thyroid (RPKM 6.7), lymph node (RPKM 4.3) and 25 other tissues See more Orthologs mouse all
ZFP64, Official Symbol ZFP64provided by HGNC Official Full Name ZFP64 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:15940 See related Ensembl:ENSG00000020256 MIM:618111; AllianceGenome:HGNC:15940 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF338 Summary Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of cytokine production and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.7), ovary (RPKM 2.2) and 25 other tissues See more Orthologs mouse all
ZFP69, Official Symbol ZFP69provided by HGNC Official Full Name ZFP69 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:24708 See related Ensembl:ENSG00000187815 MIM:617939; AllianceGenome:HGNC:24708 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFP69A; ZNF642; ZSCAN54A; ZKSCAN23A Summary Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of lipid metabolic process. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 2.2), spleen (RPKM 1.5) and 25 other tissues See more Orthologs all
ZFP69B, Official Symbol ZFP69Bprovided by HGNC Official Full Name ZFP69 zinc finger protein Bprovided by HGNC Primary source HGNC:HGNC:28053 See related Ensembl:ENSG00000187801 AllianceGenome:HGNC:28053 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF643; ZSCAN54B; ZKSCAN23B Summary Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 1.6), appendix (RPKM 1.1) and 25 other tissues See more Orthologs all
ZFP82, Official Symbol ZFP82provided by HGNC Official Full Name ZFP82 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:28682 See related Ensembl:ENSG00000181007 AllianceGenome:HGNC:28682 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF545 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 1.5), brain (RPKM 1.3) and 24 other tissues See more Orthologs all
ZFP90, Official Symbol ZFP90provided by HGNC Official Full Name ZFP90 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:23329 See related Ensembl:ENSG00000184939 MIM:609451; AllianceGenome:HGNC:23329 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIK; NK10; ZNF756; zfp-90 Summary This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015] Expression Ubiquitous expression in ovary (RPKM 6.9), brain (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
ZFP91, Official Symbol ZFP91provided by HGNC Official Full Name ZFP91 zinc finger protein, atypical E3 ubiquitin ligaseprovided by HGNC Primary source HGNC:HGNC:14983 See related Ensembl:ENSG00000186660 MIM:619289; AllianceGenome:HGNC:14983 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757 Summary The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010] Expression Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues See more Orthologs mouse all
ZFP91P1, Official Symbol ZFP91P1provided by HGNC Official Full Name ZFP91 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54652 See related Ensembl:ENSG00000274010 AllianceGenome:HGNC:54652 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZFP92, Official Symbol ZFP92provided by HGNC Official Full Name ZFP92 zinc finger proteinprovided by HGNC Primary source HGNC:HGNC:12865 See related Ensembl:ENSG00000189420 AllianceGenome:HGNC:12865 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF897 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in ovary (RPKM 2.1), bone marrow (RPKM 1.1) and 19 other tissues See more Orthologs all
ZFPL1, Official Symbol ZFPL1provided by HGNC Official Full Name zinc finger protein like 1provided by HGNC Primary source HGNC:HGNC:12868 See related Ensembl:ENSG00000162300 MIM:619397; AllianceGenome:HGNC:12868 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCG4; D11S750 Summary Predicted to enable metal ion binding activity. Predicted to be involved in vesicle-mediated transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 12.5), ovary (RPKM 11.1) and 25 other tissues See more Orthologs mouse all
ZFPM1, Official Symbol ZFPM1provided by HGNC Official Full Name zinc finger protein, FOG family member 1provided by HGNC Primary source HGNC:HGNC:19762 See related Ensembl:ENSG00000179588 MIM:601950; AllianceGenome:HGNC:19762 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A Summary Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in platelet formation; regulation of definitive erythrocyte differentiation; and regulation of gene expression. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in stomach (RPKM 2.3), duodenum (RPKM 1.0) and 20 other tissues See more Orthologs mouse all
ZFPM1-AS1, Official Symbol ZFPM1-AS1provided by HGNC Official Full Name ZFPM1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55351 See related Ensembl:ENSG00000261744 AllianceGenome:HGNC:55351 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ZFPM2, Official Symbol ZFPM2provided by HGNC Official Full Name zinc finger protein, FOG family member 2provided by HGNC Primary source HGNC:HGNC:16700 See related Ensembl:ENSG00000169946 MIM:603693; AllianceGenome:HGNC:16700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIH3; FOG2; SRXY9; ZNF89B; hFOG-2; ZC2HC11B Summary The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008] Expression Broad expression in ovary (RPKM 10.1), endometrium (RPKM 2.6) and 16 other tissues See more Orthologs mouse all
ZFR, Official Symbol ZFRprovided by HGNC Official Full Name zinc finger RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:17277 See related Ensembl:ENSG00000056097 MIM:615635; AllianceGenome:HGNC:17277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFR1; SPG71 Summary This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in brain (RPKM 34.3), testis (RPKM 25.1) and 25 other tissues See more Orthologs mouse all
ZFR2, Official Symbol ZFR2provided by HGNC Official Full Name zinc finger RNA binding protein 2provided by HGNC Primary source HGNC:HGNC:29189 See related Ensembl:ENSG00000105278 MIM:619284; AllianceGenome:HGNC:29189 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA1086 Summary Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 2.0), brain (RPKM 1.5) and 1 other tissue See more Orthologs mouse all
ZFX, Official Symbol ZFXprovided by HGNC Official Full Name zinc finger protein X-linkedprovided by HGNC Primary source HGNC:HGNC:12869 See related Ensembl:ENSG00000005889 MIM:314980; AllianceGenome:HGNC:12869 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF926 Summary This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010] Expression Ubiquitous expression in endometrium (RPKM 5.2), thyroid (RPKM 4.9) and 25 other tissues See more Orthologs mouse all
ZFX-AS1, Official Symbol ZFX-AS1provided by HGNC Official Full Name ZFX antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40617 See related Ensembl:ENSG00000234230 AllianceGenome:HGNC:40617 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ZFY, Official Symbol ZFYprovided by HGNC Official Full Name zinc finger protein Y-linkedprovided by HGNC Primary source HGNC:HGNC:12870 See related Ensembl:ENSG00000067646 MIM:490000; AllianceGenome:HGNC:12870 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF911 Summary This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008] Annotation information Note: This gene is annotated on the Y chromosome of the reference genome and HuRef assemblies but is annotated on the X chromosome of the Celera assembly (as gene LOC100130829 and model XM_001713692.1). [18 Feb 2009] Expression Broad expression in testis (RPKM 3.4), prostate (RPKM 3.2) and 20 other tissues See more Orthologs all
ZFY-AS1, Official Symbol ZFY-AS1provided by HGNC Official Full Name ZFY antisense RNA 1provided by HGNC Primary source HGNC:HGNC:38798 See related Ensembl:ENSG00000233070 AllianceGenome:HGNC:38798 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFYAS; ZFY-AS Expression Broad expression in esophagus (RPKM 5.7), appendix (RPKM 5.2) and 16 other tissues See more
ZFYVE1, Official Symbol ZFYVE1provided by HGNC Official Full Name zinc finger FYVE-type containing 1provided by HGNC Primary source HGNC:HGNC:13180 See related Ensembl:ENSG00000165861 MIM:605471; AllianceGenome:HGNC:13180 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172 Summary The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
ZFYVE16, Official Symbol ZFYVE16provided by HGNC Official Full Name zinc finger FYVE-type containing 16provided by HGNC Primary source HGNC:HGNC:20756 See related Ensembl:ENSG00000039319 MIM:608880; AllianceGenome:HGNC:20756 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPP1R69 Summary This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in brain (RPKM 10.1), endometrium (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
ZFYVE19, Official Symbol ZFYVE19provided by HGNC Official Full Name zinc finger FYVE-type containing 19provided by HGNC Primary source HGNC:HGNC:20758 See related Ensembl:ENSG00000166140 MIM:619635; AllianceGenome:HGNC:20758 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANCHR; PFIC9; MPFYVE Summary Enables phosphatidylinositol-3-phosphate binding activity. Involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Located in centrosome; cleavage furrow; and midbody. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 6.2), small intestine (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
ZFYVE21, Official Symbol ZFYVE21provided by HGNC Official Full Name zinc finger FYVE-type containing 21provided by HGNC Primary source HGNC:HGNC:20760 See related Ensembl:ENSG00000100711 MIM:613504; AllianceGenome:HGNC:20760 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZF21; HCVP7TP1 Summary Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 36.0), endometrium (RPKM 31.2) and 25 other tissues See more Orthologs mouse all
ZFYVE26, Official Symbol ZFYVE26provided by HGNC Official Full Name zinc finger FYVE-type containing 26provided by HGNC Primary source HGNC:HGNC:20761 See related Ensembl:ENSG00000072121 MIM:612012; AllianceGenome:HGNC:20761 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPG15; FYVE-CENT Summary This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in skin (RPKM 3.6), spleen (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
ZFYVE27, Official Symbol ZFYVE27provided by HGNC Official Full Name zinc finger FYVE-type containing 27provided by HGNC Primary source HGNC:HGNC:26559 See related Ensembl:ENSG00000155256 MIM:610243; AllianceGenome:HGNC:26559 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPG33; PROTRUDIN Summary This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in small intestine (RPKM 6.9), duodenum (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
ZFYVE28, Official Symbol ZFYVE28provided by HGNC Official Full Name zinc finger FYVE-type containing 28provided by HGNC Primary source HGNC:HGNC:29334 See related Ensembl:ENSG00000159733 MIM:614176; AllianceGenome:HGNC:29334 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LST2; LYST2; lst-2 Summary Enables phosphatidylinositol-3-phosphate binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 1.1), brain (RPKM 1.1) and 25 other tissues See more Orthologs mouse all
ZFYVE9, Official Symbol ZFYVE9provided by HGNC Official Full Name zinc finger FYVE-type containing 9provided by HGNC Primary source HGNC:HGNC:6775 See related Ensembl:ENSG00000157077 MIM:603755; AllianceGenome:HGNC:6775 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSP; SARA; MADHIP; SMADIP; PPP1R173 Summary This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] Expression Ubiquitous expression in brain (RPKM 8.0), thyroid (RPKM 7.9) and 25 other tissues See more Orthologs mouse all
ZFYVE9P1, Official Symbol ZFYVE9P1provided by HGNC Official Full Name zinc finger FYVE-type containing 9 pseudogene 1provided by HGNC Primary source HGNC:HGNC:33359 See related Ensembl:ENSG00000229562 AllianceGenome:HGNC:33359 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo