psui3905/ncbi_genes_summary huggingface dataset:
CDKN2B, Official Symbol CDKN2Bprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 2Bprovided by HGNC Primary source HGNC:HGNC:1788 See related Ensembl:ENSG00000147883 MIM:600431; AllianceGenome:HGNC:1788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P15; MTS2; TP15; CDK4I; INK4B; p15INK4b Summary This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 20.3), small intestine (RPKM 17.6) and 17 other tissues See more Orthologs mouse all
CDKN2B-AS1, Official Symbol CDKN2B-AS1provided by HGNC Official Full Name CDKN2B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:34341 See related Ensembl:ENSG00000240498 MIM:613149; AllianceGenome:HGNC:34341 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANRIL; p15AS; PCAT12; CDKN2BAS; CDKN2B-AS; NCRNA00089 Summary This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014] Expression Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.7) and 1 other tissue See more
CDKN2C, Official Symbol CDKN2Cprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 2Cprovided by HGNC Primary source HGNC:HGNC:1789 See related Ensembl:ENSG00000123080 MIM:603369; AllianceGenome:HGNC:1789 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p18; INK4C; p18-INK4C Summary The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 34.6), ovary (RPKM 9.5) and 22 other tissues See more Orthologs mouse all
CDKN2D, Official Symbol CDKN2Dprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 2Dprovided by HGNC Primary source HGNC:HGNC:1790 See related Ensembl:ENSG00000129355 MIM:600927; AllianceGenome:HGNC:1790 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p19; INK4D; p19-INK4D Summary The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 80.4), brain (RPKM 18.7) and 5 other tissues See more Orthologs mouse all
CDKN3, Official Symbol CDKN3provided by HGNC Official Full Name cyclin dependent kinase inhibitor 3provided by HGNC Primary source HGNC:HGNC:1791 See related Ensembl:ENSG00000100526 MIM:123832; AllianceGenome:HGNC:1791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAP; CDI1; CIP2; KAP1 Summary The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Biased expression in testis (RPKM 79.3), bone marrow (RPKM 10.8) and 5 other tissues See more Orthologs mouse all
CDNF, Official Symbol CDNFprovided by HGNC Official Full Name cerebral dopamine neurotrophic factorprovided by HGNC Primary source HGNC:HGNC:24913 See related Ensembl:ENSG00000185267 MIM:611233; AllianceGenome:HGNC:24913 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARMETL1 Summary Predicted to enable growth factor activity. Predicted to be involved in dopaminergic neuron differentiation and neuron projection development. Predicted to be active in endoplasmic reticulum and extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 6.6), thyroid (RPKM 2.2) and 23 other tissues See more Orthologs mouse all
CDO1, Official Symbol CDO1provided by HGNC Official Full Name cysteine dioxygenase type 1provided by HGNC Primary source HGNC:HGNC:1795 See related Ensembl:ENSG00000129596 MIM:603943; AllianceGenome:HGNC:1795 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDO-I Summary Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in L-cysteine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 94.6), fat (RPKM 66.8) and 8 other tissues See more Orthologs mouse all
CDON, Official Symbol CDONprovided by HGNC Official Full Name cell adhesion associated, oncogene regulatedprovided by HGNC Primary source HGNC:HGNC:17104 See related Ensembl:ENSG00000064309 MIM:608707; AllianceGenome:HGNC:17104 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDO; Ihog; CDON1; HPE11; ORCAM Summary This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011] Expression Broad expression in thyroid (RPKM 12.5), ovary (RPKM 11.8) and 17 other tissues See more Orthologs mouse all
CDPF1, Official Symbol CDPF1provided by HGNC Official Full Name cysteine rich DPF motif domain containing 1provided by HGNC Primary source HGNC:HGNC:33710 See related Ensembl:ENSG00000205643 AllianceGenome:HGNC:33710 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDKN1A; C22orf40 Expression Ubiquitous expression in ovary (RPKM 2.6), spleen (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
CDR2, Official Symbol CDR2provided by HGNC Official Full Name cerebellar degeneration related protein 2provided by HGNC Primary source HGNC:HGNC:1799 See related Ensembl:ENSG00000140743 MIM:117340; AllianceGenome:HGNC:1799 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Yo; CDR62 Summary Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 38.3), thyroid (RPKM 28.3) and 24 other tissues See more Orthologs mouse all
CDR2-DT, Official Symbol CDR2-DTprovided by HGNC Official Full Name CDR2 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55381 See related Ensembl:ENSG00000260790 AllianceGenome:HGNC:55381 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDR2L, Official Symbol CDR2Lprovided by HGNC Official Full Name cerebellar degeneration related protein 2 likeprovided by HGNC Primary source HGNC:HGNC:29999 See related Ensembl:ENSG00000109089 AllianceGenome:HGNC:29999 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HUMPPA Summary Enables identical protein binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in duodenum (RPKM 11.0), stomach (RPKM 7.1) and 23 other tissues See more Orthologs mouse all
CDRT15, Official Symbol CDRT15provided by HGNC Official Full Name CMT1A duplicated region transcript 15provided by HGNC Primary source HGNC:HGNC:14395 See related Ensembl:ENSG00000223510 AllianceGenome:HGNC:14395 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 6.0), lymph node (RPKM 0.6) and 2 other tissues See more Orthologs all
CDRT15L2, Official Symbol CDRT15L2provided by HGNC Official Full Name CMT1A duplicated region transcript 15 like 2provided by HGNC Primary source HGNC:HGNC:34075 See related Ensembl:ENSG00000214819 AllianceGenome:HGNC:34075 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 4.8) See more Orthologs all
CDRT15P13, Official Symbol CDRT15P13provided by HGNC Official Full Name CDRT15 pseudogene 13provided by HGNC Primary source HGNC:HGNC:54920 See related AllianceGenome:HGNC:54920 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDRT15P2, Official Symbol CDRT15P2provided by HGNC Official Full Name CDRT15 pseudogene 2provided by HGNC Primary source HGNC:HGNC:34074 See related AllianceGenome:HGNC:34074 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDRT15L1 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 4.4) See more
CDRT15P3, Official Symbol CDRT15P3provided by HGNC Official Full Name CDRT15 pseudogene 3provided by HGNC Primary source HGNC:HGNC:33824 See related Ensembl:ENSG00000290618 AllianceGenome:HGNC:33824 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf27B Expression Broad expression in testis (RPKM 1.2), brain (RPKM 0.8) and 19 other tissues See more
CDRT15P4, Official Symbol CDRT15P4provided by HGNC Official Full Name CDRT15 pseudogene 4provided by HGNC Primary source HGNC:HGNC:54913 See related Ensembl:ENSG00000287071 AllianceGenome:HGNC:54913 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDRT15P7, Official Symbol CDRT15P7provided by HGNC Official Full Name CDRT15 pseudogene 7provided by HGNC Primary source HGNC:HGNC:54915 See related AllianceGenome:HGNC:54915 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDRT4, Official Symbol CDRT4provided by HGNC Official Full Name CMT1A duplicated region transcript 4provided by HGNC Primary source HGNC:HGNC:14383 See related Ensembl:ENSG00000239704 AllianceGenome:HGNC:14383 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 6.9), skin (RPKM 5.8) and 25 other tissues See more Orthologs mouse all
CDRT7, Official Symbol CDRT7provided by HGNC Official Full Name CMT1A duplicated region transcript 7provided by HGNC Primary source HGNC:HGNC:14386 See related Ensembl:ENSG00000259944 AllianceGenome:HGNC:14386 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00025; NCRNA00025
CDS1, Official Symbol CDS1provided by HGNC Official Full Name CDP-diacylglycerol synthase 1provided by HGNC Primary source HGNC:HGNC:1800 See related Ensembl:ENSG00000163624 MIM:603548; AllianceGenome:HGNC:1800 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDS 1 Summary Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008] Expression Broad expression in duodenum (RPKM 20.9), thyroid (RPKM 19.8) and 17 other tissues See more Orthologs mouse all
CDS2, Official Symbol CDS2provided by HGNC Official Full Name CDP-diacylglycerol synthase 2provided by HGNC Primary source HGNC:HGNC:1801 See related Ensembl:ENSG00000101290 MIM:603549; AllianceGenome:HGNC:1801 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 21.0), heart (RPKM 9.4) and 24 other tissues See more Orthologs mouse all
CDSN, Official Symbol CDSNprovided by HGNC Official Full Name corneodesmosinprovided by HGNC Primary source HGNC:HGNC:1802 See related Ensembl:ENSG00000204539 MIM:602593; AllianceGenome:HGNC:1802 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSS; HTSS; PSS1; HTSS1; HYPT2 Summary This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014] Expression Restricted expression toward skin (RPKM 78.3) See more Orthologs mouse all
CDT1, Official Symbol CDT1provided by HGNC Official Full Name chromatin licensing and DNA replication factor 1provided by HGNC Primary source HGNC:HGNC:24576 See related Ensembl:ENSG00000167513 MIM:605525; AllianceGenome:HGNC:24576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUP; RIS2 Summary The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011] Expression Biased expression in bone marrow (RPKM 13.5), placenta (RPKM 2.5) and 9 other tissues See more Orthologs mouse all
CDV3, Official Symbol CDV3provided by HGNC Official Full Name CDV3 homologprovided by HGNC Primary source HGNC:HGNC:26928 See related Ensembl:ENSG00000091527 MIM:618789; AllianceGenome:HGNC:26928 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H41 Summary Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 58.2), appendix (RPKM 45.7) and 25 other tissues See more Orthologs mouse all
CDX1, Official Symbol CDX1provided by HGNC Official Full Name caudal type homeobox 1provided by HGNC Primary source HGNC:HGNC:1805 See related Ensembl:ENSG00000113722 MIM:600746; AllianceGenome:HGNC:1805 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008] Expression Biased expression in colon (RPKM 56.3), small intestine (RPKM 34.1) and 2 other tissues See more Orthologs mouse all
CDX2, Official Symbol CDX2provided by HGNC Official Full Name caudal type homeobox 2provided by HGNC Primary source HGNC:HGNC:1806 See related Ensembl:ENSG00000165556 MIM:600297; AllianceGenome:HGNC:1806 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDX3; CDX-3; CDX2/AS Summary This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012] Expression Biased expression in colon (RPKM 23.4), small intestine (RPKM 15.9) and 2 other tissues See more Orthologs mouse all
CDX4, Official Symbol CDX4provided by HGNC Official Full Name caudal type homeobox 4provided by HGNC Primary source HGNC:HGNC:1808 See related Ensembl:ENSG00000131264 MIM:300025; AllianceGenome:HGNC:1808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012] Expression Low expression observed in reference dataset See more Orthologs mouse all
CDY1, Official Symbol CDY1provided by HGNC Official Full Name chromodomain Y-linked 1provided by HGNC Primary source HGNC:HGNC:1809 See related Ensembl:ENSG00000172288 MIM:400016; AllianceGenome:HGNC:1809 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDY; CDY1A Summary This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 2.1) See more
CDY11P, Official Symbol CDY11Pprovided by HGNC Official Full Name chromodomain Y-linked 11 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23852 See related AllianceGenome:HGNC:23852 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY12P, Official Symbol CDY12Pprovided by HGNC Official Full Name chromodomain Y-linked 12 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23856 See related Ensembl:ENSG00000228850 AllianceGenome:HGNC:23856 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY13P, Official Symbol CDY13Pprovided by HGNC Official Full Name chromodomain Y-linked 13 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23857 See related Ensembl:ENSG00000224873 AllianceGenome:HGNC:23857 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY14P, Official Symbol CDY14Pprovided by HGNC Official Full Name chromodomain Y-linked 14 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23858 See related Ensembl:ENSG00000226873 AllianceGenome:HGNC:23858 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY17P, Official Symbol CDY17Pprovided by HGNC Official Full Name chromodomain Y-linked 17 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23861 See related AllianceGenome:HGNC:23861 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY1B, Official Symbol CDY1Bprovided by HGNC Official Full Name chromodomain Y-linked 1Bprovided by HGNC Primary source HGNC:HGNC:23920 See related Ensembl:ENSG00000172352 AllianceGenome:HGNC:23920 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDY Summary This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 2.1) See more
CDY20P, Official Symbol CDY20Pprovided by HGNC Official Full Name chromodomain Y-linked 20 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23864 See related Ensembl:ENSG00000225609 AllianceGenome:HGNC:23864 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY23P, Official Symbol CDY23Pprovided by HGNC Official Full Name chromodomain Y-linked 23 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23867 See related Ensembl:ENSG00000231716 AllianceGenome:HGNC:23867 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY2A, Official Symbol CDY2Aprovided by HGNC Official Full Name chromodomain Y-linked 2Aprovided by HGNC Primary source HGNC:HGNC:1810 See related Ensembl:ENSG00000182415 MIM:400018; AllianceGenome:HGNC:1810 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDY; CDY2 Summary This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008]
CDY2B, Official Symbol CDY2Bprovided by HGNC Official Full Name chromodomain Y-linked 2Bprovided by HGNC Primary source HGNC:HGNC:23921 See related Ensembl:ENSG00000129873 AllianceGenome:HGNC:23921 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDY Summary This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008]
CDY3P, Official Symbol CDY3Pprovided by HGNC Official Full Name chromodomain Y-linked 3 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23849 See related AllianceGenome:HGNC:23849 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY4P, Official Symbol CDY4Pprovided by HGNC Official Full Name chromodomain Y-linked 4 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23872 See related AllianceGenome:HGNC:23872 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY7P, Official Symbol CDY7Pprovided by HGNC Official Full Name chromodomain Y-linked 7 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23854 See related Ensembl:ENSG00000237558 AllianceGenome:HGNC:23854 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDY8P, Official Symbol CDY8Pprovided by HGNC Official Full Name chromodomain Y-linked 8 pseudogeneprovided by HGNC Primary source HGNC:HGNC:23855 See related Ensembl:ENSG00000224033 AllianceGenome:HGNC:23855 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDYL, Official Symbol CDYLprovided by HGNC Official Full Name chromodomain Y likeprovided by HGNC Primary source HGNC:HGNC:1811 See related Ensembl:ENSG00000153046 MIM:603778; AllianceGenome:HGNC:1811 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDYL1 Summary Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 8.5), endometrium (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
CDYL-AS1, Official Symbol CDYL-AS1provided by HGNC Official Full Name CDYL antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40142 See related Ensembl:ENSG00000236336 AllianceGenome:HGNC:40142 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.4) See more
CDYL2, Official Symbol CDYL2provided by HGNC Official Full Name chromodomain Y like 2provided by HGNC Primary source HGNC:HGNC:23030 See related Ensembl:ENSG00000166446 MIM:618816; AllianceGenome:HGNC:23030 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCCP1 Summary Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 6.1), placenta (RPKM 3.9) and 20 other tissues See more Orthologs mouse all
CDYLP1, Official Symbol CDYLP1provided by HGNC Official Full Name CDYL pseudogene 1provided by HGNC Primary source HGNC:HGNC:52805 See related AllianceGenome:HGNC:52805 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CEACAM1, Official Symbol CEACAM1provided by HGNC Official Full Name CEA cell adhesion molecule 1provided by HGNC Primary source HGNC:HGNC:1814 See related Ensembl:ENSG00000079385 MIM:109770; AllianceGenome:HGNC:1814 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BGP; BGP1; BGPI Summary This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010] Expression Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues See more Orthologs all
CEACAM16, Official Symbol CEACAM16provided by HGNC Official Full Name CEA cell adhesion molecule 16, tectorial membrane componentprovided by HGNC Primary source HGNC:HGNC:31948 See related Ensembl:ENSG00000213892 MIM:614591; AllianceGenome:HGNC:31948 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEAL2; DFNA4B; DFNB113 Summary The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012] Expression Low expression observed in reference dataset See more Orthologs mouse all
CEACAM18, Official Symbol CEACAM18provided by HGNC Official Full Name CEA cell adhesion molecule 18provided by HGNC Primary source HGNC:HGNC:31949 See related Ensembl:ENSG00000213822 AllianceGenome:HGNC:31949 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in duodenum (RPKM 5.4) and small intestine (RPKM 3.6) See more Orthologs mouse all
CEACAM19, Official Symbol CEACAM19provided by HGNC Official Full Name CEA cell adhesion molecule 19provided by HGNC Primary source HGNC:HGNC:31951 See related Ensembl:ENSG00000186567 MIM:606691; AllianceGenome:HGNC:31951 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEAL1; CEACM19 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 5.4), testis (RPKM 2.3) and 24 other tissues See more Orthologs mouse all
CEACAM20, Official Symbol CEACAM20provided by HGNC Official Full Name CEA cell adhesion molecule 20provided by HGNC Primary source HGNC:HGNC:24879 See related Ensembl:ENSG00000273777 AllianceGenome:HGNC:24879 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNQ9366 Summary Predicted to be involved in positive regulation of cytokine production. Predicted to act upstream of or within response to bacterium. Predicted to be located in apical plasma membrane and microvillus membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 13.3), duodenum (RPKM 12.5) and 1 other tissue See more Orthologs mouse all
CEACAM21, Official Symbol CEACAM21provided by HGNC Official Full Name CEA cell adhesion molecule 21provided by HGNC Primary source HGNC:HGNC:28834 See related Ensembl:ENSG00000007129 MIM:618191; AllianceGenome:HGNC:28834 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEACAM3; R29124_1 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 2.0), bone marrow (RPKM 1.9) and 15 other tissues See more Orthologs all
CEACAM3, Official Symbol CEACAM3provided by HGNC Official Full Name CEA cell adhesion molecule 3provided by HGNC Primary source HGNC:HGNC:1815 See related Ensembl:ENSG00000170956 MIM:609142; AllianceGenome:HGNC:1815 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEA; CGM1; W264; W282; CD66D; CGM1a Summary This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] Expression Biased expression in bone marrow (RPKM 11.7), appendix (RPKM 5.0) and 3 other tissues See more Orthologs all
CEACAM4, Official Symbol CEACAM4provided by HGNC Official Full Name CEA cell adhesion molecule 4provided by HGNC Primary source HGNC:HGNC:1816 See related Ensembl:ENSG00000105352 MIM:619159; AllianceGenome:HGNC:1816 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCA; CGM7; CGM7_HUMAN Summary Involved in phagocytosis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 8.4), spleen (RPKM 4.0) and 4 other tissues See more Orthologs all
CEACAM5, Official Symbol CEACAM5provided by HGNC Official Full Name CEA cell adhesion molecule 5provided by HGNC Primary source HGNC:HGNC:1817 See related Ensembl:ENSG00000105388 MIM:114890; AllianceGenome:HGNC:1817 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEA; CD66e Summary This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] Expression Biased expression in colon (RPKM 540.8), appendix (RPKM 102.3) and 2 other tissues See more Orthologs all
CEACAM6, Official Symbol CEACAM6provided by HGNC Official Full Name CEA cell adhesion molecule 6provided by HGNC Primary source HGNC:HGNC:1818 See related Ensembl:ENSG00000086548 MIM:163980; AllianceGenome:HGNC:1818 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCA; CEAL; CD66c; NCA-50/90 Summary This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014] Expression Biased expression in colon (RPKM 147.4), lung (RPKM 142.2) and 9 other tissues See more Orthologs all
CEACAM7, Official Symbol CEACAM7provided by HGNC Official Full Name CEA cell adhesion molecule 7provided by HGNC Primary source HGNC:HGNC:1819 See related Ensembl:ENSG00000007306 MIM:619160; AllianceGenome:HGNC:1819 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGM2 Summary This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] Expression Restricted expression toward colon (RPKM 448.6) See more Orthologs all