psui3905/ncbi_genes_summary huggingface dataset:
OSBPL5, Official Symbol OSBPL5provided by HGNC Official Full Name oxysterol binding protein like 5provided by HGNC Primary source HGNC:HGNC:16392 See related Ensembl:ENSG00000021762 MIM:606733; AllianceGenome:HGNC:16392 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORP5; OBPH1 Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in spleen (RPKM 7.8), endometrium (RPKM 5.8) and 24 other tissues See more Orthologs mouse all
OSBPL6, Official Symbol OSBPL6provided by HGNC Official Full Name oxysterol binding protein like 6provided by HGNC Primary source HGNC:HGNC:16388 See related Ensembl:ENSG00000079156 MIM:606734; AllianceGenome:HGNC:16388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORP6 Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 4.0), skin (RPKM 2.6) and 21 other tissues See more Orthologs mouse all
OSBPL7, Official Symbol OSBPL7provided by HGNC Official Full Name oxysterol binding protein like 7provided by HGNC Primary source HGNC:HGNC:16387 See related Ensembl:ENSG00000006025 MIM:606735; AllianceGenome:HGNC:16387 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORP7 Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in stomach (RPKM 18.4), duodenum (RPKM 12.5) and 22 other tissues See more Orthologs mouse all
OSBPL8, Official Symbol OSBPL8provided by HGNC Official Full Name oxysterol binding protein like 8provided by HGNC Primary source HGNC:HGNC:16396 See related Ensembl:ENSG00000091039 MIM:606736; AllianceGenome:HGNC:16396 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORP8; MST120; OSBP10; MSTP120 Summary This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in kidney (RPKM 16.1), lymph node (RPKM 15.4) and 25 other tissues See more Orthologs mouse all
OSBPL9, Official Symbol OSBPL9provided by HGNC Official Full Name oxysterol binding protein like 9provided by HGNC Primary source HGNC:HGNC:16386 See related Ensembl:ENSG00000117859 MIM:606737; AllianceGenome:HGNC:16386 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORP9; ORP-9 Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in kidney (RPKM 20.1), thyroid (RPKM 18.0) and 25 other tissues See more Orthologs mouse all
OSBPL9P1, Official Symbol OSBPL9P1provided by HGNC Official Full Name oxysterol binding protein like 9 pseudogene 1provided by HGNC Primary source HGNC:HGNC:48731 See related Ensembl:ENSG00000271389 AllianceGenome:HGNC:48731 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OSBPL9P3, Official Symbol OSBPL9P3provided by HGNC Official Full Name oxysterol binding protein like 9 pseudogene 3provided by HGNC Primary source HGNC:HGNC:48733 See related Ensembl:ENSG00000255070 AllianceGenome:HGNC:48733 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OSBPL9P5, Official Symbol OSBPL9P5provided by HGNC Official Full Name oxysterol binding protein like 9 pseudogene 5provided by HGNC Primary source HGNC:HGNC:48735 See related Ensembl:ENSG00000256285 AllianceGenome:HGNC:48735 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OSCAR, Official Symbol OSCARprovided by HGNC Official Full Name osteoclast associated Ig-like receptorprovided by HGNC Primary source HGNC:HGNC:29960 See related Ensembl:ENSG00000170909 MIM:606862; AllianceGenome:HGNC:29960 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIGR3; PIgR-3 Summary Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] Expression Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues See more Orthologs mouse all
OSCP1, Official Symbol OSCP1provided by HGNC Official Full Name organic solute carrier partner 1provided by HGNC Primary source HGNC:HGNC:29971 See related Ensembl:ENSG00000116885 MIM:608854; AllianceGenome:HGNC:29971 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOR1; C1orf102 Summary Enables transmembrane transporter activity. Involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basal plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 27.5), thyroid (RPKM 6.0) and 13 other tissues See more Orthologs mouse all
OSER1, Official Symbol OSER1provided by HGNC Official Full Name oxidative stress responsive serine rich 1provided by HGNC Primary source HGNC:HGNC:16105 See related Ensembl:ENSG00000132823 AllianceGenome:HGNC:16105 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Osr1; Perit1; HSPC207; C20orf111; dJ1183I21.1 Summary Predicted to be involved in cellular response to hydrogen peroxide. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 25.7), bone marrow (RPKM 22.5) and 24 other tissues See more Orthologs mouse all
OSER1-DT, Official Symbol OSER1-DTprovided by HGNC Official Full Name OSER1 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:48585 See related Ensembl:ENSG00000223891 AllianceGenome:HGNC:48585 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSER1-AS1 Expression Ubiquitous expression in ovary (RPKM 6.2), brain (RPKM 5.4) and 25 other tissues See more
OSGEP, Official Symbol OSGEPprovided by HGNC Official Full Name O-sialoglycoprotein endopeptidaseprovided by HGNC Primary source HGNC:HGNC:18028 See related Ensembl:ENSG00000092094 MIM:610107; AllianceGenome:HGNC:18028 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAE1; TCS3; GCPL1; GAMOS3; OSGEP1; PRSMG1 Summary Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 14.4), lymph node (RPKM 12.5) and 25 other tissues See more Orthologs mouse all
OSGEPL1, Official Symbol OSGEPL1provided by HGNC Official Full Name O-sialoglycoprotein endopeptidase like 1provided by HGNC Primary source HGNC:HGNC:23075 See related Ensembl:ENSG00000128694 MIM:619634; AllianceGenome:HGNC:23075 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Qri7; OSGEPL Summary Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 2.6), testis (RPKM 2.5) and 25 other tissues See more Orthologs mouse all
OSGEPL1-AS1, Official Symbol OSGEPL1-AS1provided by HGNC Official Full Name OSGEPL1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41009 See related AllianceGenome:HGNC:41009 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
OSGIN1, Official Symbol OSGIN1provided by HGNC Official Full Name oxidative stress induced growth inhibitor 1provided by HGNC Primary source HGNC:HGNC:30093 See related Ensembl:ENSG00000140961 MIM:607975; AllianceGenome:HGNC:30093 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDGI; OKL38 Summary This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011] Expression Broad expression in liver (RPKM 32.8), duodenum (RPKM 12.4) and 14 other tissues See more Orthologs mouse all
OSGIN2, Official Symbol OSGIN2provided by HGNC Official Full Name oxidative stress induced growth inhibitor family member 2provided by HGNC Primary source HGNC:HGNC:1355 See related Ensembl:ENSG00000164823 MIM:604598; AllianceGenome:HGNC:1355 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hT41; C8orf1 Summary Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 10.6), brain (RPKM 9.0) and 25 other tissues See more Orthologs mouse all
OSM, Official Symbol OSMprovided by HGNC Official Full Name oncostatin Mprovided by HGNC Primary source HGNC:HGNC:8506 See related Ensembl:ENSG00000099985 MIM:165095; AllianceGenome:HGNC:8506 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Biased expression in bone marrow (RPKM 29.4), appendix (RPKM 5.8) and 4 other tissues See more Orthologs mouse all
OSMR, Official Symbol OSMRprovided by HGNC Official Full Name oncostatin M receptorprovided by HGNC Primary source HGNC:HGNC:8507 See related Ensembl:ENSG00000145623 MIM:601743; AllianceGenome:HGNC:8507 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSMRB; PLCA1; IL-31RB; OSMRbeta; IL-31R-beta Summary This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in gall bladder (RPKM 13.2), placenta (RPKM 11.5) and 24 other tissues See more Orthologs mouse all
OSR1, Official Symbol OSR1provided by HGNC Official Full Name odd-skipped related transcription factor 1provided by HGNC Primary source HGNC:HGNC:8111 See related Ensembl:ENSG00000143867 MIM:608891; AllianceGenome:HGNC:8111 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ODD Summary Enables sequence-specific double-stranded DNA binding activity. Involved in negative regulation of ion transmembrane transporter activity; positive regulation of gastrulation; and pronephros development. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: OSR1 (Gene ID: 130497) and OXSR1 (Gene ID: 9943) share the OSR1 symbol/alias in common. OSR1 is a widely used alternative name for oxidative stress responsive 1 (OXSR1). [29 Jun 2018] Expression Broad expression in salivary gland (RPKM 5.4), endometrium (RPKM 5.3) and 19 other tissues See more Orthologs mouse all
OSR2, Official Symbol OSR2provided by HGNC Official Full Name odd-skipped related transciption factor 2provided by HGNC Primary source HGNC:HGNC:15830 See related Ensembl:ENSG00000164920 MIM:611297; AllianceGenome:HGNC:15830 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008] Expression Biased expression in endometrium (RPKM 68.5), ovary (RPKM 33.5) and 8 other tissues See more Orthologs mouse all
OST4, Official Symbol OST4provided by HGNC Official Full Name oligosaccharyltransferase complex subunit 4, non-catalyticprovided by HGNC Primary source HGNC:HGNC:32483 See related Ensembl:ENSG00000228474 MIM:618932; AllianceGenome:HGNC:32483 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 112.3), adrenal (RPKM 106.4) and 25 other tissues See more Orthologs mouse all
OSTC, Official Symbol OSTCprovided by HGNC Official Full Name oligosaccharyltransferase complex non-catalytic subunitprovided by HGNC Primary source HGNC:HGNC:24448 See related Ensembl:ENSG00000198856 MIM:619023; AllianceGenome:HGNC:24448 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DC2 Summary Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues See more Orthologs mouse all
OSTCP1, Official Symbol OSTCP1provided by HGNC Official Full Name oligosaccharyltransferase complex subunit pseudogene 1provided by HGNC Primary source HGNC:HGNC:30530 See related Ensembl:ENSG00000243775 AllianceGenome:HGNC:30530 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DC2L; OSTCL Expression Low expression observed in reference dataset See more
OSTCP2, Official Symbol OSTCP2provided by HGNC Official Full Name oligosaccharyltransferase complex subunit pseudogene 2provided by HGNC Primary source HGNC:HGNC:42864 See related AllianceGenome:HGNC:42864 Gene type protein coding RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OSTCP3, Official Symbol OSTCP3provided by HGNC Official Full Name oligosaccharyltransferase complex subunit pseudogene 3provided by HGNC Primary source HGNC:HGNC:42865 See related Ensembl:ENSG00000269608 AllianceGenome:HGNC:42865 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
OSTF1, Official Symbol OSTF1provided by HGNC Official Full Name osteoclast stimulating factor 1provided by HGNC Primary source HGNC:HGNC:8510 See related Ensembl:ENSG00000134996 MIM:610180; AllianceGenome:HGNC:8510 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSF; SH3P2; bA235O14.1 Summary Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in spleen (RPKM 44.5), esophagus (RPKM 43.2) and 25 other tissues See more Orthologs mouse all
OSTM1, Official Symbol OSTM1provided by HGNC Official Full Name osteoclastogenesis associated transmembrane protein 1provided by HGNC Primary source HGNC:HGNC:21652 See related Ensembl:ENSG00000081087 MIM:607649; AllianceGenome:HGNC:21652 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GL; GIPN; OPTB5; HSPC019 Summary This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 17.8), adrenal (RPKM 13.8) and 24 other tissues See more Orthologs mouse all
OSTM1-AS1, Official Symbol OSTM1-AS1provided by HGNC Official Full Name OSTM1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:43666 See related Ensembl:ENSG00000225174 AllianceGenome:HGNC:43666 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
OSTN, Official Symbol OSTNprovided by HGNC Official Full Name osteocrinprovided by HGNC Primary source HGNC:HGNC:29961 See related Ensembl:ENSG00000188729 MIM:610280; AllianceGenome:HGNC:29961 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MUSCLIN Summary Predicted to enable signaling receptor binding activity. Involved in negative regulation of dendrite extension. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
OSTN-AS1, Official Symbol OSTN-AS1provided by HGNC Official Full Name OSTN antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41250 See related Ensembl:ENSG00000233308 AllianceGenome:HGNC:41250 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
OTC, Official Symbol OTCprovided by HGNC Official Full Name ornithine transcarbamylaseprovided by HGNC Primary source HGNC:HGNC:8512 See related Ensembl:ENSG00000036473 MIM:300461; AllianceGenome:HGNC:8512 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OCTD; OTC1; OTCD; OTCase Summary This nuclear gene encodes a mitochondrial matrix enzyme. The encoded protein is involved in the urea cycle which functions to detoxify ammonia into urea for excretion. Mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. [provided by RefSeq, May 2022] Expression Biased expression in liver (RPKM 75.1), duodenum (RPKM 47.8) and 1 other tissue See more Orthologs mouse all
OTOA, Official Symbol OTOAprovided by HGNC Official Full Name otoancorinprovided by HGNC Primary source HGNC:HGNC:16378 See related Ensembl:ENSG00000155719 MIM:607038; AllianceGenome:HGNC:16378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT108; DFNB22 Summary The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Biased expression in testis (RPKM 1.9), spleen (RPKM 0.7) and 4 other tissues See more Orthologs mouse all
OTOF, Official Symbol OTOFprovided by HGNC Official Full Name otoferlinprovided by HGNC Primary source HGNC:HGNC:8515 See related Ensembl:ENSG00000115155 MIM:603681; AllianceGenome:HGNC:8515 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AUNB1; DFNB6; DFNB9; NSRD9; FER1L2 Summary Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has 3 C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has 6 C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
OTOG, Official Symbol OTOGprovided by HGNC Official Full Name otogelinprovided by HGNC Primary source HGNC:HGNC:8516 See related Ensembl:ENSG00000188162 MIM:604487; AllianceGenome:HGNC:8516 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTGN; MLEMP; DFNB18B Summary The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all
OTOGL, Official Symbol OTOGLprovided by HGNC Official Full Name otogelin likeprovided by HGNC Primary source HGNC:HGNC:26901 See related Ensembl:ENSG00000165899 MIM:614925; AllianceGenome:HGNC:26901 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB84B; C12orf64 Summary The protein encoded by this gene belongs to the otogelin family. This gene is expressed in the inner ear of vertebrates with the highest level of expression seen at the embryonic stage and lowest in adult. Knockdown studies in zebrafish suggest that this gene is essential for normal inner ear function. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2012] Expression Biased expression in kidney (RPKM 2.9), heart (RPKM 0.7) and 3 other tissues See more Orthologs mouse all
OTOL1, Official Symbol OTOL1provided by HGNC Official Full Name otolin 1provided by HGNC Primary source HGNC:HGNC:34071 See related Ensembl:ENSG00000182447 AllianceGenome:HGNC:34071 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1QTNF15; C1QTNF16 Summary This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin-1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance deficits resulting from vestibular dysfunction. [provided by RefSeq, Jul 2017] Expression Low expression observed in reference dataset See more Orthologs mouse all
OTOP1, Official Symbol OTOP1provided by HGNC Official Full Name otopetrin 1provided by HGNC Primary source HGNC:HGNC:19656 See related Ensembl:ENSG00000163982 MIM:607806; AllianceGenome:HGNC:19656 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a transmembrane protein which belongs to the otopetrin domain protein family and is required for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals that are required for the detection of linear acceleration and gravity. This gene modulates purinergic control of intracellular calcium in vestibular supporting cells. Naturally occurring mutations in the orthologous mouse gene are associated with nonsyndromic otoconia agenesis and a consequent balance defect. The orthologous mouse gene is also induced in white adipose tissue during obesity. The encoded protein is a component of a counterinflammatory pathway that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. [provided by RefSeq, Jul 2017] Expression Low expression observed in reference dataset See more Orthologs mouse all
OTOP2, Official Symbol OTOP2provided by HGNC Official Full Name otopetrin 2provided by HGNC Primary source HGNC:HGNC:19657 See related Ensembl:ENSG00000183034 MIM:607827; AllianceGenome:HGNC:19657 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 10.3), testis (RPKM 1.8) and 1 other tissue See more Orthologs mouse all
OTOP3, Official Symbol OTOP3provided by HGNC Official Full Name otopetrin 3provided by HGNC Primary source HGNC:HGNC:19658 See related Ensembl:ENSG00000182938 MIM:607828; AllianceGenome:HGNC:19658 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 38.1), small intestine (RPKM 6.4) and 1 other tissue See more Orthologs mouse all
OTOR, Official Symbol OTORprovided by HGNC Official Full Name otoraplinprovided by HGNC Primary source HGNC:HGNC:8517 See related Ensembl:ENSG00000125879 MIM:606067; AllianceGenome:HGNC:8517 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FDP; MIAL1 Summary This gene encodes a member of the melanoma-inhibiting activity gene family. The encoded protein is secreted via the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness. [provided by RefSeq, Jul 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all
OTOS, Official Symbol OTOSprovided by HGNC Official Full Name otospiralinprovided by HGNC Primary source HGNC:HGNC:22644 See related Ensembl:ENSG00000178602 MIM:607877; AllianceGenome:HGNC:22644 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTOSP Summary Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin in guinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 [PubMed 12687421]).[supplied by OMIM, Mar 2008] Expression Restricted expression toward thyroid (RPKM 6.1) See more Orthologs mouse all
OTP, Official Symbol OTPprovided by HGNC Official Full Name orthopedia homeoboxprovided by HGNC Primary source HGNC:HGNC:8518 See related Ensembl:ENSG00000171540 MIM:604529; AllianceGenome:HGNC:8518 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
OTUB1, Official Symbol OTUB1provided by HGNC Official Full Name OTU deubiquitinase, ubiquitin aldehyde binding 1provided by HGNC Primary source HGNC:HGNC:23077 See related Ensembl:ENSG00000167770 MIM:608337; AllianceGenome:HGNC:23077 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTB1; OTU1; HSPC263 Summary The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 29.9), placenta (RPKM 22.0) and 25 other tissues See more Orthologs mouse all
OTUB2, Official Symbol OTUB2provided by HGNC Official Full Name OTU deubiquitinase, ubiquitin aldehyde binding 2provided by HGNC Primary source HGNC:HGNC:20351 See related Ensembl:ENSG00000089723 MIM:608338; AllianceGenome:HGNC:20351 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTB2; OTU2; C14orf137 Summary This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues See more Orthologs mouse all
OTUD1, Official Symbol OTUD1provided by HGNC Official Full Name OTU deubiquitinase 1provided by HGNC Primary source HGNC:HGNC:27346 See related Ensembl:ENSG00000165312 MIM:612022; AllianceGenome:HGNC:27346 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUBA7; OTDC1 Summary Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008] Orthologs mouse all
OTUD3, Official Symbol OTUD3provided by HGNC Official Full Name OTU deubiquitinase 3provided by HGNC Primary source HGNC:HGNC:29038 See related Ensembl:ENSG00000169914 MIM:611758; AllianceGenome:HGNC:29038 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUBA4 Summary Enables thiol-dependent deubiquitinase. Acts upstream of or within negative regulation of protein kinase B signaling; protein deubiquitination; and protein stabilization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 8.1), endometrium (RPKM 3.2) and 23 other tissues See more Orthologs mouse all
OTUD4, Official Symbol OTUD4provided by HGNC Official Full Name OTU deubiquitinase 4provided by HGNC Primary source HGNC:HGNC:24949 See related Ensembl:ENSG00000164164 MIM:611744; AllianceGenome:HGNC:24949 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HIN1; DUBA6; HSHIN1 Summary Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in testis (RPKM 19.7), bone marrow (RPKM 11.0) and 25 other tissues See more Orthologs mouse all
OTUD5, Official Symbol OTUD5provided by HGNC Official Full Name OTU deubiquitinase 5provided by HGNC Primary source HGNC:HGNC:25402 See related Ensembl:ENSG00000068308 MIM:300713; AllianceGenome:HGNC:25402 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUBA; MCAND Summary This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in brain (RPKM 16.1), spleen (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
OTUD6A, Official Symbol OTUD6Aprovided by HGNC Official Full Name OTU deubiquitinase 6Aprovided by HGNC Primary source HGNC:HGNC:32312 See related Ensembl:ENSG00000189401 MIM:300714; AllianceGenome:HGNC:32312 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUBA2; HSHIN6 Summary Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008] Orthologs mouse all
OTUD6B, Official Symbol OTUD6Bprovided by HGNC Official Full Name OTU deubiquitinase 6Bprovided by HGNC Primary source HGNC:HGNC:24281 See related Ensembl:ENSG00000155100 MIM:612021; AllianceGenome:HGNC:24281 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DUBA5; CGI-77; DUBA-5; IDDFSDA Summary This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013] Expression Ubiquitous expression in brain (RPKM 6.6), testis (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
OTUD6B-AS1, Official Symbol OTUD6B-AS1provided by HGNC Official Full Name OTUD6B antisense RNA 1 (head to head)provided by HGNC Primary source HGNC:HGNC:50466 See related Ensembl:ENSG00000253738 AllianceGenome:HGNC:50466 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GS1-251I9.4 Expression Ubiquitous expression in thyroid (RPKM 8.2), brain (RPKM 7.9) and 25 other tissues See more
OTUD7A, Official Symbol OTUD7Aprovided by HGNC Official Full Name OTU deubiquitinase 7Aprovided by HGNC Primary source HGNC:HGNC:20718 See related Ensembl:ENSG00000169918 MIM:612024; AllianceGenome:HGNC:20718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTUD7; C15orf16; C16ORF15; CEZANNE2 Summary The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016] Expression Broad expression in brain (RPKM 2.7), testis (RPKM 2.0) and 18 other tissues See more Orthologs mouse all
OTUD7B, Official Symbol OTUD7Bprovided by HGNC Official Full Name OTU deubiquitinase 7Bprovided by HGNC Primary source HGNC:HGNC:16683 See related Ensembl:ENSG00000264522 MIM:611748; AllianceGenome:HGNC:16683 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZA20D1; CEZANNE Summary Enables Lys48-specific deubiquitinase activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues See more Orthologs mouse all