psui3905/ncbi_genes_summary huggingface dataset:
TJAP1, Official Symbol TJAP1provided by HGNC Official Full Name tight junction associated protein 1provided by HGNC Primary source HGNC:HGNC:17949 See related Ensembl:ENSG00000137221 MIM:612658; AllianceGenome:HGNC:17949 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PILT; TJP4 Summary This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
TJAP1P1, Official Symbol TJAP1P1provided by HGNC Official Full Name TJAP1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:55129 See related AllianceGenome:HGNC:55129 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TJP1, Official Symbol TJP1provided by HGNC Official Full Name tight junction protein 1provided by HGNC Primary source HGNC:HGNC:11827 See related Ensembl:ENSG00000104067 MIM:601009; AllianceGenome:HGNC:11827 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZO-1 Summary This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in testis (RPKM 23.9), placenta (RPKM 23.2) and 24 other tissues See more Orthologs mouse all
TJP2, Official Symbol TJP2provided by HGNC Official Full Name tight junction protein 2provided by HGNC Primary source HGNC:HGNC:11828 See related Ensembl:ENSG00000119139 MIM:607709; AllianceGenome:HGNC:11828 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZO2; X104; FHCA1; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11 Summary This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in lung (RPKM 15.3), fat (RPKM 14.2) and 25 other tissues See more Orthologs mouse all
TJP3, Official Symbol TJP3provided by HGNC Official Full Name tight junction protein 3provided by HGNC Primary source HGNC:HGNC:11829 See related Ensembl:ENSG00000105289 MIM:612689; AllianceGenome:HGNC:11829 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZO3; ZO-3 Summary The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012] Expression Biased expression in colon (RPKM 22.4), duodenum (RPKM 17.0) and 13 other tissues See more Orthologs mouse all
TK1, Official Symbol TK1provided by HGNC Official Full Name thymidine kinase 1provided by HGNC Primary source HGNC:HGNC:11830 See related Ensembl:ENSG00000167900 MIM:188300; AllianceGenome:HGNC:11830 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TK2 Summary The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016] Expression Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 12.6) and 18 other tissues See more Orthologs mouse all
TK2, Official Symbol TK2provided by HGNC Official Full Name thymidine kinase 2provided by HGNC Primary source HGNC:HGNC:11831 See related Ensembl:ENSG00000166548 MIM:188250; AllianceGenome:HGNC:11831 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTTK; PEOB3; SCA31; MTDPS2; TK2-EXT Summary This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in fat (RPKM 14.4), testis (RPKM 9.6) and 25 other tissues See more Orthologs mouse all
TKFC, Official Symbol TKFCprovided by HGNC Official Full Name triokinase and FMN cyclaseprovided by HGNC Primary source HGNC:HGNC:24552 See related Ensembl:ENSG00000149476 MIM:615844; AllianceGenome:HGNC:24552 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DAK; NET45; TKFCD Summary This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017] Expression Broad expression in duodenum (RPKM 30.4), small intestine (RPKM 22.4) and 23 other tissues See more Orthologs mouse all
TKT, Official Symbol TKTprovided by HGNC Official Full Name transketolaseprovided by HGNC Primary source HGNC:HGNC:11834 See related Ensembl:ENSG00000163931 MIM:606781; AllianceGenome:HGNC:11834 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TK; TKT1; SDDHD; HEL107; HEL-S-48 Summary This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] Expression Broad expression in bone marrow (RPKM 210.7), fat (RPKM 83.0) and 22 other tissues See more Orthologs mouse all
TKTL1, Official Symbol TKTL1provided by HGNC Official Full Name transketolase like 1provided by HGNC Primary source HGNC:HGNC:11835 See related Ensembl:ENSG00000007350 MIM:300044; AllianceGenome:HGNC:11835 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TKR; TKT2 Summary The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Expression Restricted expression toward testis (RPKM 88.4) See more Orthologs mouse all
TKTL2, Official Symbol TKTL2provided by HGNC Official Full Name transketolase like 2provided by HGNC Primary source HGNC:HGNC:25313 See related Ensembl:ENSG00000151005 AllianceGenome:HGNC:25313 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
TLCD1, Official Symbol TLCD1provided by HGNC Official Full Name TLC domain containing 1provided by HGNC Primary source HGNC:HGNC:25177 See related Ensembl:ENSG00000160606 AllianceGenome:HGNC:25177 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 8.5), lymph node (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
TLCD2, Official Symbol TLCD2provided by HGNC Official Full Name TLC domain containing 2provided by HGNC Primary source HGNC:HGNC:33522 See related Ensembl:ENSG00000185561 AllianceGenome:HGNC:33522 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 9.2), colon (RPKM 5.9) and 17 other tissues See more Orthologs mouse all
TLCD3A, Official Symbol TLCD3Aprovided by HGNC Official Full Name TLC domain containing 3Aprovided by HGNC Primary source HGNC:HGNC:29646 See related Ensembl:ENSG00000167695 MIM:611627; AllianceGenome:HGNC:29646 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT120; FAM57A Summary The protein encoded by this gene is a membrane-associated protein that promotes lung carcinogenesis. The encoded protein may be involved in amino acid transport and glutathione metabolism since it can interact with a solute carrier family member (SLC3A2) and an isoform of gamma-glutamyltranspeptidase-like 3. An alternatively spliced variant encoding a protein that lacks a 32 aa internal segment showed the opposite effect, inhibiting lung cancer cell growth. Knockdown of this gene also inhibited lung carcinogenesis and tumor cell growth. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] Expression Broad expression in skin (RPKM 26.1), esophagus (RPKM 9.7) and 18 other tissues See more Orthologs mouse all
TLCD3B, Official Symbol TLCD3Bprovided by HGNC Official Full Name TLC domain containing 3Bprovided by HGNC Primary source HGNC:HGNC:25295 See related Ensembl:ENSG00000149926 MIM:615175; AllianceGenome:HGNC:25295 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CORD22; FAM57B; FP1188 Summary This gene encodes a transmembrane protein, which may be a likely target of peroxisome proliferator-activated receptor gamma (PPAR-gamma). The product of the orthologous gene in mouse is related to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Restricted expression toward testis (RPKM 12.4) See more Orthologs mouse all
TLCD4, Official Symbol TLCD4provided by HGNC Official Full Name TLC domain containing 4provided by HGNC Primary source HGNC:HGNC:26477 See related Ensembl:ENSG00000152078 AllianceGenome:HGNC:26477 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMEM56 Summary Predicted to be involved in lipid homeostasis. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in liver (RPKM 27.2), heart (RPKM 9.3) and 19 other tissues See more Orthologs mouse all
TLCD4-RWDD3, Official Symbol TLCD4-RWDD3provided by HGNC Official Full Name TLCD4-RWDD3 readthroughprovided by HGNC Primary source HGNC:HGNC:49388 See related Ensembl:ENSG00000271092 AllianceGenome:HGNC:49388 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMEM56-RWDD3 Summary This locus represents naturally occurring read-through transcription between the neighboring TMEM56 (transmembrane protein 56) and RWDD3 (RWD domain containing 3) genes on chromosome 1. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but it contains a distinct C-terminus due to frameshifts versus the downstream gene coding sequence. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in liver (RPKM 11.5), heart (RPKM 6.5) and 25 other tissues See more Orthologs all
TLCD5, Official Symbol TLCD5provided by HGNC Official Full Name TLC domain containing 5provided by HGNC Primary source HGNC:HGNC:28280 See related Ensembl:ENSG00000181264 AllianceGenome:HGNC:28280 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMEM136 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in adrenal (RPKM 4.7), brain (RPKM 4.1) and 21 other tissues See more Orthologs mouse all
TLDC2, Official Symbol TLDC2provided by HGNC Official Full Name TBC/LysM-associated domain containing 2provided by HGNC Primary source HGNC:HGNC:16112 See related Ensembl:ENSG00000101342 AllianceGenome:HGNC:16112 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C20orf118 Summary Predicted to be involved in response to oxidative stress. Predicted to act upstream of or within negative regulation of oxidative stress-induced neuron death. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in appendix (RPKM 10.6), small intestine (RPKM 8.5) and 25 other tissues See more Orthologs mouse all
TLE1, Official Symbol TLE1provided by HGNC Official Full Name TLE family member 1, transcriptional corepressorprovided by HGNC Primary source HGNC:HGNC:11837 See related Ensembl:ENSG00000196781 MIM:600189; AllianceGenome:HGNC:11837 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESG; ESG1; GRG1; TLE-1 Summary Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 15.1), endometrium (RPKM 10.2) and 25 other tissues See more Orthologs all
TLE2, Official Symbol TLE2provided by HGNC Official Full Name TLE family member 2, transcriptional corepressorprovided by HGNC Primary source HGNC:HGNC:11838 See related Ensembl:ENSG00000065717 MIM:601041; AllianceGenome:HGNC:11838 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESG; ESG2; GRG2 Summary Enables transcription corepressor activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in salivary gland (RPKM 17.9), fat (RPKM 13.6) and 24 other tissues See more Orthologs mouse all
TLE3, Official Symbol TLE3provided by HGNC Official Full Name TLE family member 3, transcriptional corepressorprovided by HGNC Primary source HGNC:HGNC:11839 See related Ensembl:ENSG00000140332 MIM:600190; AllianceGenome:HGNC:11839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESG; ESG3; GRG3; HsT18976 Summary This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
TLE4, Official Symbol TLE4provided by HGNC Official Full Name TLE family member 4, transcriptional corepressorprovided by HGNC Primary source HGNC:HGNC:11840 See related Ensembl:ENSG00000106829 MIM:605132; AllianceGenome:HGNC:11840 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl) Summary Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues See more Orthologs mouse all
TLE5, Official Symbol TLE5provided by HGNC Official Full Name TLE family member 5, transcriptional modulatorprovided by HGNC Primary source HGNC:HGNC:307 See related Ensembl:ENSG00000104964 MIM:600188; AllianceGenome:HGNC:307 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AES; GRG; ESP1; GRG5; AES-1; AES-2; Grg-5 Summary The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 135.6), spleen (RPKM 116.8) and 25 other tissues See more Orthologs mouse all
TLE6, Official Symbol TLE6provided by HGNC Official Full Name TLE family member 6, subcortical maternal complex memberprovided by HGNC Primary source HGNC:HGNC:30788 See related Ensembl:ENSG00000104953 MIM:612399; AllianceGenome:HGNC:30788 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRG6; PREMBL; OZEMA15 Summary This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Expression Broad expression in thyroid (RPKM 2.5), placenta (RPKM 2.5) and 21 other tissues See more Orthologs mouse all
TLE7, Official Symbol TLE7provided by HGNC Official Full Name TLE family member 7provided by HGNC Primary source HGNC:HGNC:53648 See related Ensembl:ENSG00000260734 AllianceGenome:HGNC:53648 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as chico Summary Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
TLK1, Official Symbol TLK1provided by HGNC Official Full Name tousled like kinase 1provided by HGNC Primary source HGNC:HGNC:11841 See related Ensembl:ENSG00000198586 MIM:608438; AllianceGenome:HGNC:11841 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKU-beta Summary The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] Expression Ubiquitous expression in testis (RPKM 13.5), thyroid (RPKM 10.7) and 25 other tissues See more Orthologs mouse all
TLK2, Official Symbol TLK2provided by HGNC Official Full Name tousled like kinase 2provided by HGNC Primary source HGNC:HGNC:11842 See related Ensembl:ENSG00000146872 MIM:608439; AllianceGenome:HGNC:11842 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HsHPK; MRD57; PKU-ALPHA Summary This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
TLK2P1, Official Symbol TLK2P1provided by HGNC Official Full Name tousled like kinase 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:18048 See related Ensembl:ENSG00000226049 AllianceGenome:HGNC:18048 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLK2ps1
TLK2P2, Official Symbol TLK2P2provided by HGNC Official Full Name tousled like kinase 2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:22227 See related Ensembl:ENSG00000228828 AllianceGenome:HGNC:22227 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLK2ps2
TLL1, Official Symbol TLL1provided by HGNC Official Full Name tolloid like 1provided by HGNC Primary source HGNC:HGNC:11843 See related Ensembl:ENSG00000038295 MIM:606742; AllianceGenome:HGNC:11843 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLL; ASD6 Summary This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Expression Broad expression in placenta (RPKM 2.3), gall bladder (RPKM 1.2) and 21 other tissues See more Orthologs mouse all
TLL2, Official Symbol TLL2provided by HGNC Official Full Name tolloid like 2provided by HGNC Primary source HGNC:HGNC:11844 See related Ensembl:ENSG00000095587 MIM:606743; AllianceGenome:HGNC:11844 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
TLN1, Official Symbol TLN1provided by HGNC Official Full Name talin 1provided by HGNC Primary source HGNC:HGNC:11845 See related Ensembl:ENSG00000137076 MIM:186745; AllianceGenome:HGNC:11845 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLN; ILWEQ; talin-1 Summary This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009] Expression Ubiquitous expression in fat (RPKM 74.7), spleen (RPKM 60.6) and 25 other tissues See more Orthologs mouse all
TLN2, Official Symbol TLN2provided by HGNC Official Full Name talin 2provided by HGNC Primary source HGNC:HGNC:15447 See related Ensembl:ENSG00000171914 MIM:607349; AllianceGenome:HGNC:15447 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILWEQ Summary This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 12.9), brain (RPKM 11.8) and 19 other tissues See more Orthologs mouse all
TLNRD1, Official Symbol TLNRD1provided by HGNC Official Full Name talin rod domain containing 1provided by HGNC Primary source HGNC:HGNC:13519 See related Ensembl:ENSG00000140406 MIM:615466; AllianceGenome:HGNC:13519 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MESDC1 Summary This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016] Orthologs mouse all
TLR1, Official Symbol TLR1provided by HGNC Official Full Name toll like receptor 1provided by HGNC Primary source HGNC:HGNC:11847 See related Ensembl:ENSG00000174125 MIM:601194; AllianceGenome:HGNC:11847 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIL; CD281; rsc786; TIL. LPRS5 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 7.0), spleen (RPKM 4.9) and 24 other tissues See more Orthologs mouse all
TLR10, Official Symbol TLR10provided by HGNC Official Full Name toll like receptor 10provided by HGNC Primary source HGNC:HGNC:15634 See related Ensembl:ENSG00000174123 MIM:606270; AllianceGenome:HGNC:15634 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD290 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010] Expression Biased expression in lymph node (RPKM 20.4), spleen (RPKM 11.7) and 3 other tissues See more Orthologs all
TLR12P, Official Symbol TLR12Pprovided by HGNC Official Full Name toll like receptor 12, pseudogeneprovided by HGNC Primary source HGNC:HGNC:31754 See related Ensembl:ENSG00000234512 AllianceGenome:HGNC:31754 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to act upstream of or within defense response to protozoan. [provided by Alliance of Genome Resources, Apr 2022]
TLR2, Official Symbol TLR2provided by HGNC Official Full Name toll like receptor 2provided by HGNC Primary source HGNC:HGNC:11848 See related Ensembl:ENSG00000137462 MIM:603028; AllianceGenome:HGNC:11848 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIL4; CD282 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Broad expression in appendix (RPKM 15.9), bone marrow (RPKM 12.6) and 18 other tissues See more Orthologs mouse all
TLR3, Official Symbol TLR3provided by HGNC Official Full Name toll like receptor 3provided by HGNC Primary source HGNC:HGNC:11849 See related Ensembl:ENSG00000164342 MIM:603029; AllianceGenome:HGNC:11849 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD283; IIAE2; IMD83 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in duodenum (RPKM 5.4), small intestine (RPKM 5.0) and 24 other tissues See more Orthologs mouse all
TLR4, Official Symbol TLR4provided by HGNC Official Full Name toll like receptor 4provided by HGNC Primary source HGNC:HGNC:11850 See related Ensembl:ENSG00000136869 MIM:603030; AllianceGenome:HGNC:11850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOLL; CD284; TLR-4; ARMD10 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment. Expression Broad expression in spleen (RPKM 17.1), appendix (RPKM 15.6) and 22 other tissues See more Orthologs mouse all
TLR5, Official Symbol TLR5provided by HGNC Official Full Name toll like receptor 5provided by HGNC Primary source HGNC:HGNC:11851 See related Ensembl:ENSG00000187554 MIM:603031; AllianceGenome:HGNC:11851 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLE1; TIL3; SLEB1; MELIOS Summary This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] Expression Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues See more Orthologs mouse all
TLR6, Official Symbol TLR6provided by HGNC Official Full Name toll like receptor 6provided by HGNC Primary source HGNC:HGNC:16711 See related Ensembl:ENSG00000174130 MIM:605403; AllianceGenome:HGNC:16711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD286 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011] Expression Broad expression in appendix (RPKM 4.9), spleen (RPKM 4.1) and 20 other tissues See more Orthologs mouse all
TLR7, Official Symbol TLR7provided by HGNC Official Full Name toll like receptor 7provided by HGNC Primary source HGNC:HGNC:15631 See related Ensembl:ENSG00000196664 MIM:300365; AllianceGenome:HGNC:15631 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD74; SLEB17; TLR7-like Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Broad expression in placenta (RPKM 3.3), appendix (RPKM 3.0) and 23 other tissues See more Orthologs mouse all
TLR8, Official Symbol TLR8provided by HGNC Official Full Name toll like receptor 8provided by HGNC Primary source HGNC:HGNC:15632 See related Ensembl:ENSG00000101916 MIM:300366; AllianceGenome:HGNC:15632 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD288; IMD98; TLR-8; hTLR8 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 9 other tissues See more Orthologs mouse all
TLR8-AS1, Official Symbol TLR8-AS1provided by HGNC Official Full Name TLR8 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40720 See related Ensembl:ENSG00000233338 AllianceGenome:HGNC:40720 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GS1-324M7.6 Expression Low expression observed in reference dataset See more