psui3905/ncbi_genes_summary huggingface dataset:
NUP188, Official Symbol NUP188provided by HGNC Official Full Name nucleoporin 188provided by HGNC Primary source HGNC:HGNC:17859 See related Ensembl:ENSG00000095319 MIM:615587; AllianceGenome:HGNC:17859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hNup188; KIAA0169; SANDSTEF Summary The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013] Expression Broad expression in testis (RPKM 47.7), skin (RPKM 10.9) and 23 other tissues See more Orthologs mouse all
NUP205, Official Symbol NUP205provided by HGNC Official Full Name nucleoporin 205provided by HGNC Primary source HGNC:HGNC:18658 See related Ensembl:ENSG00000155561 MIM:614352; AllianceGenome:HGNC:18658 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPHS13; C7orf14 Summary This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
NUP210, Official Symbol NUP210provided by HGNC Official Full Name nucleoporin 210provided by HGNC Primary source HGNC:HGNC:30052 See related Ensembl:ENSG00000132182 MIM:607703; AllianceGenome:HGNC:30052 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP210; POM210 Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013] Expression Broad expression in lymph node (RPKM 17.2), bone marrow (RPKM 15.9) and 22 other tissues See more Orthologs mouse all
NUP210L, Official Symbol NUP210Lprovided by HGNC Official Full Name nucleoporin 210 likeprovided by HGNC Primary source HGNC:HGNC:29915 See related Ensembl:ENSG00000143552 AllianceGenome:HGNC:29915 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to act upstream of or within Sertoli cell development and spermatid development. Predicted to be integral component of membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 16.4) See more Orthologs mouse all
NUP210P1, Official Symbol NUP210P1provided by HGNC Official Full Name nucleoporin 210 pseudogene 1provided by HGNC Primary source HGNC:HGNC:27399 See related Ensembl:ENSG00000198284 AllianceGenome:HGNC:27399 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3orf46 Expression Restricted expression toward testis (RPKM 2.3) See more
NUP214, Official Symbol NUP214provided by HGNC Official Full Name nucleoporin 214provided by HGNC Primary source HGNC:HGNC:8064 See related Ensembl:ENSG00000126883 MIM:114350; AllianceGenome:HGNC:8064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAN; CAIN; IIAE9 Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] Expression Broad expression in testis (RPKM 32.1), spleen (RPKM 10.1) and 24 other tissues See more Orthologs mouse all
NUP35, Official Symbol NUP35provided by HGNC Official Full Name nucleoporin 35provided by HGNC Primary source HGNC:HGNC:29797 See related Ensembl:ENSG00000163002 MIM:608140; AllianceGenome:HGNC:29797 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MP44; NP44; MP-44; NUP53 Summary This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013] Expression Ubiquitous expression in testis (RPKM 6.9), adrenal (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
NUP35P1, Official Symbol NUP35P1provided by HGNC Official Full Name nucleoporin 35 pseudogene 1provided by HGNC Primary source HGNC:HGNC:52370 See related AllianceGenome:HGNC:52370 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUP37, Official Symbol NUP37provided by HGNC Official Full Name nucleoporin 37provided by HGNC Primary source HGNC:HGNC:29929 See related Ensembl:ENSG00000075188 MIM:609264; AllianceGenome:HGNC:29929 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p37; MCPH24 Summary Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in lymph node (RPKM 10.3), testis (RPKM 8.5) and 25 other tissues See more Orthologs mouse all
NUP42, Official Symbol NUP42provided by HGNC Official Full Name nucleoporin 42provided by HGNC Primary source HGNC:HGNC:17010 See related Ensembl:ENSG00000136243 MIM:619998; AllianceGenome:HGNC:17010 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CG1; NLP1; UIP1; hCG1; NLP-1; NLP_1; NUPL2 Summary Enables nuclear export signal receptor activity. Involved in protein export from nucleus. Located in cytosol and nucleoplasm. Colocalizes with nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 9.0), lymph node (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
NUP43, Official Symbol NUP43provided by HGNC Official Full Name nucleoporin 43provided by HGNC Primary source HGNC:HGNC:21182 See related Ensembl:ENSG00000120253 MIM:608141; AllianceGenome:HGNC:21182 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p42; bA350J20.1 Summary Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in lymph node (RPKM 6.0), appendix (RPKM 5.2) and 25 other tissues See more Orthologs mouse all
NUP50, Official Symbol NUP50provided by HGNC Official Full Name nucleoporin 50provided by HGNC Primary source HGNC:HGNC:8065 See related Ensembl:ENSG00000093000 MIM:604646; AllianceGenome:HGNC:8065 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPAP60; NPAP60L Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 16.3), lymph node (RPKM 14.7) and 25 other tissues See more Orthologs mouse all
NUP50-DT, Official Symbol NUP50-DTprovided by HGNC Official Full Name NUP50 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:50502 See related Ensembl:ENSG00000226328 AllianceGenome:HGNC:50502 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUP50-AS1 Expression Ubiquitous expression in brain (RPKM 3.7), adrenal (RPKM 3.2) and 25 other tissues See more
NUP54, Official Symbol NUP54provided by HGNC Official Full Name nucleoporin 54provided by HGNC Primary source HGNC:HGNC:17359 See related Ensembl:ENSG00000138750 MIM:607607; AllianceGenome:HGNC:17359 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DYT37 Summary The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in bone marrow (RPKM 12.3), testis (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
NUP58, Official Symbol NUP58provided by HGNC Official Full Name nucleoporin 58provided by HGNC Primary source HGNC:HGNC:20261 See related Ensembl:ENSG00000139496 MIM:607615; AllianceGenome:HGNC:20261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUP45; NUPL1; PRO2463 Summary This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 26.3), thyroid (RPKM 10.4) and 24 other tissues See more Orthologs mouse all
NUP62, Official Symbol NUP62provided by HGNC Official Full Name nucleoporin 62provided by HGNC Primary source HGNC:HGNC:8066 See related Ensembl:ENSG00000213024 MIM:605815; AllianceGenome:HGNC:8066 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p62; IBSN; SNDI Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 21.4), appendix (RPKM 16.1) and 25 other tissues See more Orthologs mouse all
NUP62CL, Official Symbol NUP62CLprovided by HGNC Official Full Name nucleoporin 62 C-terminal likeprovided by HGNC Primary source HGNC:HGNC:25960 See related Ensembl:ENSG00000198088 AllianceGenome:HGNC:25960 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein containing a domain found in nucleoporins which are glycoproteins found in nuclear pore complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] Expression Broad expression in testis (RPKM 5.8), adrenal (RPKM 5.6) and 18 other tissues See more Orthologs mouse all
NUP85, Official Symbol NUP85provided by HGNC Official Full Name nucleoporin 85provided by HGNC Primary source HGNC:HGNC:8734 See related Ensembl:ENSG00000125450 MIM:170285; AllianceGenome:HGNC:8734 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Nup75; FROUNT; NPHS17 Summary This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in lymph node (RPKM 9.1), testis (RPKM 9.0) and 25 other tissues See more Orthologs mouse all
NUP88, Official Symbol NUP88provided by HGNC Official Full Name nucleoporin 88provided by HGNC Primary source HGNC:HGNC:8067 See related Ensembl:ENSG00000108559 MIM:602552; AllianceGenome:HGNC:8067 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FADS4 Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in testis (RPKM 25.7), lymph node (RPKM 15.5) and 25 other tissues See more Orthologs mouse all
NUP93, Official Symbol NUP93provided by HGNC Official Full Name nucleoporin 93provided by HGNC Primary source HGNC:HGNC:28958 See related Ensembl:ENSG00000102900 MIM:614351; AllianceGenome:HGNC:28958 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIC96 Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] Expression Broad expression in testis (RPKM 20.8), thyroid (RPKM 10.6) and 24 other tissues See more Orthologs mouse all
NUP93-DT, Official Symbol NUP93-DTprovided by HGNC Official Full Name NUP93 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55370 See related Ensembl:ENSG00000261302 AllianceGenome:HGNC:55370 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 1.9), brain (RPKM 0.3) and 5 other tissues See more
NUP98, Official Symbol NUP98provided by HGNC Official Full Name nucleoporin 98 and 96 precursorprovided by HGNC Primary source HGNC:HGNC:8068 See related Ensembl:ENSG00000110713 MIM:601021; AllianceGenome:HGNC:8068 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADIR2; NUP96; NUP196; Nup98-96 Summary Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016] Expression Broad expression in testis (RPKM 38.3), bone marrow (RPKM 17.8) and 25 other tissues See more Orthologs mouse all
NUPR1, Official Symbol NUPR1provided by HGNC Official Full Name nuclear protein 1, transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:29990 See related Ensembl:ENSG00000176046 MIM:614812; AllianceGenome:HGNC:29990 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P8; COM1 Summary Enables DNA binding activity and transcription coactivator activity. Involved in several processes, including regulation of cellular catabolic process; regulation of generation of precursor metabolites and energy; and regulation of programmed cell death. Acts upstream of or within negative regulation of cell cycle. Located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in thyroid (RPKM 197.1), pancreas (RPKM 192.3) and 21 other tissues See more Orthologs mouse all
NUPR2, Official Symbol NUPR2provided by HGNC Official Full Name nuclear protein 2, transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:44164 See related Ensembl:ENSG00000185290 AllianceGenome:HGNC:44164 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P8; NUPR1L Summary Involved in several processes, including cellular response to starvation; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 27.8) and kidney (RPKM 4.0) See more Orthologs mouse all
NUS1, Official Symbol NUS1provided by HGNC Official Full Name NUS1 dehydrodolichyl diphosphate synthase subunitprovided by HGNC Primary source HGNC:HGNC:21042 See related Ensembl:ENSG00000153989 MIM:610463; AllianceGenome:HGNC:21042 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NgBR; MRD55; CDG1AA; C6orf68; TANGO14; MGC:7199 Summary This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017] Expression Ubiquitous expression in thyroid (RPKM 25.1), appendix (RPKM 15.0) and 25 other tissues See more Orthologs mouse all
NUSAP1, Official Symbol NUSAP1provided by HGNC Official Full Name nucleolar and spindle associated protein 1provided by HGNC Primary source HGNC:HGNC:18538 See related Ensembl:ENSG00000137804 MIM:612818; AllianceGenome:HGNC:18538 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LNP; ANKT; SAPL; BM037; NUSAP; Q0310; PRO0310p1 Summary NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009] Expression Broad expression in bone marrow (RPKM 30.9), lymph node (RPKM 16.8) and 15 other tissues See more Orthologs mouse all
NUTF2, Official Symbol NUTF2provided by HGNC Official Full Name nuclear transport factor 2provided by HGNC Primary source HGNC:HGNC:13722 See related Ensembl:ENSG00000102898 MIM:605813; AllianceGenome:HGNC:13722 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTF2; PP15; NTF-2 Summary This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in placenta (RPKM 14.8), testis (RPKM 14.7) and 25 other tissues See more Orthologs mouse all
NUTF2P4, Official Symbol NUTF2P4provided by HGNC Official Full Name nuclear transport factor 2 pseudogene 4provided by HGNC Primary source HGNC:HGNC:50453 See related Ensembl:ENSG00000234790 AllianceGenome:HGNC:50453 Gene type protein coding RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUTF2P5, Official Symbol NUTF2P5provided by HGNC Official Full Name nuclear transport factor 2 pseudogene 5provided by HGNC Primary source HGNC:HGNC:50454 See related Ensembl:ENSG00000215227 AllianceGenome:HGNC:50454 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUTF2P6, Official Symbol NUTF2P6provided by HGNC Official Full Name nuclear transport factor 2 pseudogene 6provided by HGNC Primary source HGNC:HGNC:50455 See related Ensembl:ENSG00000259710 AllianceGenome:HGNC:50455 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NUTM1, Official Symbol NUTM1provided by HGNC Official Full Name NUT midline carcinoma family member 1provided by HGNC Primary source HGNC:HGNC:29919 See related Ensembl:ENSG00000184507 MIM:608963; AllianceGenome:HGNC:29919 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUT; FAM22H; C15orf55 Summary Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 8.8) See more Orthologs mouse all
NUTM2A, Official Symbol NUTM2Aprovided by HGNC Official Full Name NUT family member 2Aprovided by HGNC Primary source HGNC:HGNC:23438 See related Ensembl:ENSG00000184923 AllianceGenome:HGNC:23438 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM22A Expression Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 2.2) and 25 other tissues See more Orthologs all
NUTM2A-AS1, Official Symbol NUTM2A-AS1provided by HGNC Official Full Name NUTM2A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:45161 See related Ensembl:ENSG00000223482 AllianceGenome:HGNC:45161 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM22A-AS1 Expression Ubiquitous expression in fat (RPKM 7.6), testis (RPKM 5.7) and 25 other tissues See more
NUTM2B, Official Symbol NUTM2Bprovided by HGNC Official Full Name NUT family member 2Bprovided by HGNC Primary source HGNC:HGNC:23445 See related Ensembl:ENSG00000188199 AllianceGenome:HGNC:23445 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM22B; bA119F19.1 Expression Ubiquitous expression in testis (RPKM 2.9), brain (RPKM 2.0) and 25 other tissues See more
NUTM2B-AS1, Official Symbol NUTM2B-AS1provided by HGNC Official Full Name NUTM2B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51204 See related Ensembl:ENSG00000225484 MIM:618639; AllianceGenome:HGNC:51204 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPML1 Expression Ubiquitous expression in testis (RPKM 2.4), thyroid (RPKM 2.2) and 25 other tissues See more
NUTM2D, Official Symbol NUTM2Dprovided by HGNC Official Full Name NUT family member 2Dprovided by HGNC Primary source HGNC:HGNC:23447 See related Ensembl:ENSG00000214562 AllianceGenome:HGNC:23447 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM22D Expression Ubiquitous expression in testis (RPKM 1.6), brain (RPKM 1.5) and 25 other tissues See more
NUTM2E, Official Symbol NUTM2Eprovided by HGNC Official Full Name NUT family member 2Eprovided by HGNC Primary source HGNC:HGNC:23448 See related Ensembl:ENSG00000228570 AllianceGenome:HGNC:23448 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM22E Annotation information Note: This gene contains an intact open reading frame; however, it is classified as a pseudogene because no transcripts available as of August 2009 are thought to originate from this location, suggesting that this gene does not have a functional promoter. [26 Aug 2009]
NUTM2F, Official Symbol NUTM2Fprovided by HGNC Official Full Name NUT family member 2Fprovided by HGNC Primary source HGNC:HGNC:23450 See related Ensembl:ENSG00000130950 AllianceGenome:HGNC:23450 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUTMF; FAM22F Expression Biased expression in testis (RPKM 1.2), skin (RPKM 0.1) and 2 other tissues See more Orthologs all
NUTM2G, Official Symbol NUTM2Gprovided by HGNC Official Full Name NUT family member 2Gprovided by HGNC Primary source HGNC:HGNC:23449 See related Ensembl:ENSG00000188152 AllianceGenome:HGNC:23449 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUTMG; FAM22G Expression Low expression observed in reference dataset See more Orthologs all
NVL, Official Symbol NVLprovided by HGNC Official Full Name nuclear VCP likeprovided by HGNC Primary source HGNC:HGNC:8070 See related Ensembl:ENSG00000143748 MIM:602426; AllianceGenome:HGNC:8070 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NVL2 Summary This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in skin (RPKM 7.5), lymph node (RPKM 5.1) and 25 other tissues See more Orthologs mouse all
NWD1, Official Symbol NWD1provided by HGNC Official Full Name NACHT and WD repeat domain containing 1provided by HGNC Primary source HGNC:HGNC:27619 See related Ensembl:ENSG00000188039 MIM:616250; AllianceGenome:HGNC:27619 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] Expression Biased expression in prostate (RPKM 3.7), brain (RPKM 1.6) and 6 other tissues See more Orthologs mouse all
NWD2, Official Symbol NWD2provided by HGNC Official Full Name NACHT and WD repeat domain containing 2provided by HGNC Primary source HGNC:HGNC:29229 See related Ensembl:ENSG00000174145 MIM:620172; AllianceGenome:HGNC:29229 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA1239 Expression Biased expression in brain (RPKM 3.2), thyroid (RPKM 0.7) and 2 other tissues See more Orthologs mouse all
NXF1, Official Symbol NXF1provided by HGNC Official Full Name nuclear RNA export factor 1provided by HGNC Primary source HGNC:HGNC:8071 See related Ensembl:ENSG00000162231 MIM:602647; AllianceGenome:HGNC:8071 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAP; MEX67 Summary This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 39.4), spleen (RPKM 22.8) and 25 other tissues See more Orthologs mouse all
NXF2, Official Symbol NXF2provided by HGNC Official Full Name nuclear RNA export factor 2provided by HGNC Primary source HGNC:HGNC:8072 See related Ensembl:ENSG00000269405 MIM:300315; AllianceGenome:HGNC:8072 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT39; TAPL-2; TCP11X2 Summary This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013] Expression Restricted expression toward testis (RPKM 10.2) See more
NXF2B, Official Symbol NXF2Bprovided by HGNC Official Full Name nuclear RNA export factor 2Bprovided by HGNC Primary source HGNC:HGNC:23984 See related Ensembl:ENSG00000269437 AllianceGenome:HGNC:23984 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TCP11X2; bA353J17.1 Summary This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Jun 2015] Expression Restricted expression toward testis (RPKM 9.5) See more
NXF3, Official Symbol NXF3provided by HGNC Official Full Name nuclear RNA export factor 3provided by HGNC Primary source HGNC:HGNC:8073 See related Ensembl:ENSG00000147206 MIM:300316; AllianceGenome:HGNC:8073 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 42.7), gall bladder (RPKM 7.2) and 1 other tissue See more Orthologs mouse all
NXN, Official Symbol NXNprovided by HGNC Official Full Name nucleoredoxinprovided by HGNC Primary source HGNC:HGNC:18008 See related Ensembl:ENSG00000167693 MIM:612895; AllianceGenome:HGNC:18008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRX; RRS2; TRG-4 Summary This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in endometrium (RPKM 8.8), prostate (RPKM 6.7) and 24 other tissues See more Orthologs mouse all
NXNL1, Official Symbol NXNL1provided by HGNC Official Full Name nucleoredoxin like 1provided by HGNC Primary source HGNC:HGNC:25179 See related Ensembl:ENSG00000171773 MIM:608791; AllianceGenome:HGNC:25179 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDCVF; TXNL6 Summary Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. [provided by RefSeq, Dec 2015] Expression Biased expression in fat (RPKM 1.0) and adrenal (RPKM 0.2) See more Orthologs mouse all
NXNL2, Official Symbol NXNL2provided by HGNC Official Full Name nucleoredoxin like 2provided by HGNC Primary source HGNC:HGNC:30482 See related Ensembl:ENSG00000130045 MIM:615299; AllianceGenome:HGNC:30482 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RDCVF2; RdCVF2L; C9orf121 Summary Predicted to be involved in photoreceptor cell maintenance and sensory perception. Predicted to act upstream of or within sensory perception of smell and visual perception. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
NXPE1, Official Symbol NXPE1provided by HGNC Official Full Name neurexophilin and PC-esterase domain family member 1provided by HGNC Primary source HGNC:HGNC:28527 See related Ensembl:ENSG00000095110 AllianceGenome:HGNC:28527 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM55A Summary Predicted to be located in extracellular region. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward colon (RPKM 27.8) See more Orthologs all
NXPE2, Official Symbol NXPE2provided by HGNC Official Full Name neurexophilin and PC-esterase domain family member 2provided by HGNC Primary source HGNC:HGNC:26331 See related Ensembl:ENSG00000204361 AllianceGenome:HGNC:26331 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM55B Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 2.7), salivary gland (RPKM 0.7) and 2 other tissues See more Orthologs mouse all
NXPE2P1, Official Symbol NXPE2P1provided by HGNC Official Full Name neurexophilin and PC-esterase domain family member 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44082 See related Ensembl:ENSG00000255982 AllianceGenome:HGNC:44082 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
NXPE3, Official Symbol NXPE3provided by HGNC Official Full Name neurexophilin and PC-esterase domain family member 3provided by HGNC Primary source HGNC:HGNC:28238 See related Ensembl:ENSG00000144815 AllianceGenome:HGNC:28238 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM55C; MST115; MSTP115 Summary This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017] Expression Ubiquitous expression in brain (RPKM 6.4), lymph node (RPKM 5.0) and 24 other tissues See more Orthologs mouse all
NXPE4, Official Symbol NXPE4provided by HGNC Official Full Name neurexophilin and PC-esterase domain family member 4provided by HGNC Primary source HGNC:HGNC:23117 See related Ensembl:ENSG00000137634 MIM:618133; AllianceGenome:HGNC:23117 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM55D; C11orf33 Summary Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 26.5), salivary gland (RPKM 10.3) and 2 other tissues See more Orthologs mouse all