psui3905/ncbi_genes_summary huggingface dataset:
PLA2G5, Official Symbol PLA2G5provided by HGNC Official Full Name phospholipase A2 group Vprovided by HGNC Primary source HGNC:HGNC:9038 See related Ensembl:ENSG00000127472 MIM:601192; AllianceGenome:HGNC:9038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRFB; GV-PLA2; PLA2-10; hVPLA(2) Summary This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues See more Orthologs all
PLA2G6, Official Symbol PLA2G6provided by HGNC Official Full Name phospholipase A2 group VIprovided by HGNC Primary source HGNC:HGNC:9039 See related Ensembl:ENSG00000184381 MIM:603604; AllianceGenome:HGNC:9039 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GVI; PLA2; INAD1; NBIA2; iPLA2; NBIA2A; NBIA2B; PARK14; PNPLA9; CaI-PLA2; IPLA2-VIA; iPLA2beta Summary The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010] Expression Broad expression in testis (RPKM 12.7), gall bladder (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
PLA2G7, Official Symbol PLA2G7provided by HGNC Official Full Name phospholipase A2 group VIIprovided by HGNC Primary source HGNC:HGNC:9040 See related Ensembl:ENSG00000146070 MIM:601690; AllianceGenome:HGNC:9040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAFAD; PAFAH; LP-PLA2; LDL-PLA2 Summary The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009] Expression Broad expression in appendix (RPKM 6.4), lymph node (RPKM 5.5) and 18 other tissues See more Orthologs mouse all
PLA2R1, Official Symbol PLA2R1provided by HGNC Official Full Name phospholipase A2 receptor 1provided by HGNC Primary source HGNC:HGNC:9042 See related Ensembl:ENSG00000153246 MIM:604939; AllianceGenome:HGNC:9042 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R Summary This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010] Expression Broad expression in thyroid (RPKM 11.6), kidney (RPKM 5.9) and 16 other tissues See more Orthologs mouse all
PLAA, Official Symbol PLAAprovided by HGNC Official Full Name phospholipase A2 activating proteinprovided by HGNC Primary source HGNC:HGNC:9043 See related Ensembl:ENSG00000137055 MIM:603873; AllianceGenome:HGNC:9043 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOA1; PLAP; PLA2P; NDMSBA Summary Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.9), bone marrow (RPKM 5.3) and 25 other tissues See more Orthologs mouse all
PLAAT1, Official Symbol PLAAT1provided by HGNC Official Full Name phospholipase A and acyltransferase 1provided by HGNC Primary source HGNC:HGNC:14922 See related Ensembl:ENSG00000127252 MIM:606487; AllianceGenome:HGNC:14922 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A-C1; HRSL1; HSD28; HRASLS; HRASLS1; PLA/AT1; PLAAT-1; H-REV107 Summary Enables acyltransferase activity, transferring groups other than amino-acyl groups and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process and phosphatidylcholine metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues See more Orthologs mouse all
PLAAT2, Official Symbol PLAAT2provided by HGNC Official Full Name phospholipase A and acyltransferase 2provided by HGNC Primary source HGNC:HGNC:17824 See related Ensembl:ENSG00000133328 MIM:613866; AllianceGenome:HGNC:17824 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRASLS2; PLAAT-2; PLA1/2-2 Summary The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016] Expression Biased expression in duodenum (RPKM 16.4), small intestine (RPKM 9.9) and 3 other tissues See more Orthologs all
PLAAT3, Official Symbol PLAAT3provided by HGNC Official Full Name phospholipase A and acyltransferase 3provided by HGNC Primary source HGNC:HGNC:17825 See related Ensembl:ENSG00000176485 MIM:613867; AllianceGenome:HGNC:17825 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AdPLA; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1 Summary Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues See more Orthologs mouse all
PLAAT4, Official Symbol PLAAT4provided by HGNC Official Full Name phospholipase A and acyltransferase 4provided by HGNC Primary source HGNC:HGNC:9869 See related Ensembl:ENSG00000133321 MIM:605092; AllianceGenome:HGNC:9869 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIG1; TIG3; HRSL4; HRASLS4; PLAAT-4; RARRES3; PLA1/2-3 Summary Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008] Annotation information Note: RARRES3 (Gene ID: 5920) and DDX58 (Gene ID: 23586) share the RIG1/RIG-1 alias in common. RIG1 is a widely used alternative name for DExD/H-box helicase 58 (DDX58), which can be confused with the retinoic acid receptor responder 3 (RARRES3) gene, since they share the same alias. [22 Jan 2019] Expression Ubiquitous expression in small intestine (RPKM 43.2), duodenum (RPKM 36.6) and 24 other tissues See more Orthologs all
PLAAT5, Official Symbol PLAAT5provided by HGNC Official Full Name phospholipase A and acyltransferase 5provided by HGNC Primary source HGNC:HGNC:24978 See related Ensembl:ENSG00000168004 MIM:611474; AllianceGenome:HGNC:24978 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RLP1; iNAT; HRLP5; HRSL5; HRASLS5; PLAAT-5 Summary Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 31.0), fat (RPKM 23.9) and 1 other tissue See more Orthologs mouse all
PLAC1, Official Symbol PLAC1provided by HGNC Official Full Name placenta enriched 1provided by HGNC Primary source HGNC:HGNC:9044 See related Ensembl:ENSG00000170965 MIM:300296; AllianceGenome:HGNC:9044 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT92; OOSP2B; OOSP2L Summary Involved in placenta development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward placenta (RPKM 19.2) See more Orthologs mouse all
PLAC4, Official Symbol PLAC4provided by HGNC Official Full Name placenta enriched 4provided by HGNC Primary source HGNC:HGNC:14616 See related Ensembl:ENSG00000280109 MIM:613770; AllianceGenome:HGNC:14616 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRED78; C21orf115
PLAC8, Official Symbol PLAC8provided by HGNC Official Full Name placenta associated 8provided by HGNC Primary source HGNC:HGNC:19254 See related Ensembl:ENSG00000145287 MIM:607515; AllianceGenome:HGNC:19254 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C15; DGIC; onzin; PNAS-144 Summary Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 48.1), colon (RPKM 47.5) and 10 other tissues See more Orthologs mouse all
PLAC8L1, Official Symbol PLAC8L1provided by HGNC Official Full Name PLAC8 like 1provided by HGNC Primary source HGNC:HGNC:31746 See related Ensembl:ENSG00000173261 AllianceGenome:HGNC:31746 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 3.1) and skin (RPKM 0.3) See more Orthologs mouse all
PLAC9, Official Symbol PLAC9provided by HGNC Official Full Name placenta associated 9provided by HGNC Primary source HGNC:HGNC:19255 See related Ensembl:ENSG00000189129 MIM:612857; AllianceGenome:HGNC:19255 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 55.2), prostate (RPKM 10.1) and 10 other tissues See more Orthologs mouse all
PLAG1, Official Symbol PLAG1provided by HGNC Official Full Name PLAG1 zinc fingerprovided by HGNC Primary source HGNC:HGNC:9045 See related Ensembl:ENSG00000181690 MIM:603026; AllianceGenome:HGNC:9045 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSA; SGPA; SRS4; ZNF912 Summary Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 1.7), spleen (RPKM 1.3) and 23 other tissues See more Orthologs mouse all
PLAGL1, Official Symbol PLAGL1provided by HGNC Official Full Name PLAG1 like zinc finger 1provided by HGNC Primary source HGNC:HGNC:9046 See related Ensembl:ENSG00000118495 MIM:603044; AllianceGenome:HGNC:9046 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZAC; LOT1; ZAC1 Summary This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015] Expression Broad expression in placenta (RPKM 68.4), skin (RPKM 15.8) and 16 other tissues See more Orthologs mouse all
PLAGL2, Official Symbol PLAGL2provided by HGNC Official Full Name PLAG1 like zinc finger 2provided by HGNC Primary source HGNC:HGNC:9047 See related Ensembl:ENSG00000126003 MIM:604866; AllianceGenome:HGNC:9047 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF900 Summary Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues See more Orthologs mouse all
PLAT, Official Symbol PLATprovided by HGNC Official Full Name plasminogen activator, tissue typeprovided by HGNC Primary source HGNC:HGNC:9051 See related Ensembl:ENSG00000104368 MIM:173370; AllianceGenome:HGNC:9051 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPA; T-PA Summary This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Broad expression in urinary bladder (RPKM 61.1), placenta (RPKM 41.3) and 18 other tissues See more Orthologs mouse all
PLAU, Official Symbol PLAUprovided by HGNC Official Full Name plasminogen activator, urokinaseprovided by HGNC Primary source HGNC:HGNC:9052 See related Ensembl:ENSG00000122861 MIM:191840; AllianceGenome:HGNC:9052 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATF; QPD; UPA; URK; u-PA; BDPLT5 Summary This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Expression Broad expression in appendix (RPKM 23.1), urinary bladder (RPKM 22.7) and 23 other tissues See more Orthologs mouse all
PLAUR, Official Symbol PLAURprovided by HGNC Official Full Name plasminogen activator, urokinase receptorprovided by HGNC Primary source HGNC:HGNC:9053 See related Ensembl:ENSG00000011422 MIM:173391; AllianceGenome:HGNC:9053 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD87; UPAR; URKR; U-PAR Summary This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 100.8), gall bladder (RPKM 18.1) and 5 other tissues See more Orthologs mouse all
PLB1, Official Symbol PLB1provided by HGNC Official Full Name phospholipase B1provided by HGNC Primary source HGNC:HGNC:30041 See related Ensembl:ENSG00000163803 MIM:610179; AllianceGenome:HGNC:30041 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLB; PLB/LIP Summary This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016] Expression Biased expression in small intestine (RPKM 8.9), bone marrow (RPKM 1.8) and 8 other tissues See more Orthologs mouse all
PLBD1, Official Symbol PLBD1provided by HGNC Official Full Name phospholipase B domain containing 1provided by HGNC Primary source HGNC:HGNC:26215 See related Ensembl:ENSG00000121316 MIM:618486; AllianceGenome:HGNC:26215 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 104.6), colon (RPKM 35.9) and 17 other tissues See more Orthologs mouse all
PLBD1-AS1, Official Symbol PLBD1-AS1provided by HGNC Official Full Name PLBD1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51143 See related Ensembl:ENSG00000256751 AllianceGenome:HGNC:51143 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in colon (RPKM 12.9), duodenum (RPKM 12.8) and 20 other tissues See more
PLBD2, Official Symbol PLBD2provided by HGNC Official Full Name phospholipase B domain containing 2provided by HGNC Primary source HGNC:HGNC:27283 See related Ensembl:ENSG00000151176 MIM:620097; AllianceGenome:HGNC:27283 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P76 Summary Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 36.9), ovary (RPKM 20.4) and 25 other tissues See more Orthologs mouse all
PLCB1, Official Symbol PLCB1provided by HGNC Official Full Name phospholipase C beta 1provided by HGNC Primary source HGNC:HGNC:15917 See related Ensembl:ENSG00000182621 MIM:607120; AllianceGenome:HGNC:15917 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE12; PLC-I; EIEE12; PI-PLC; PLC154; PLCB1A; PLCB1B; PLC-154; PLC-beta-1 Summary The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 18.8), salivary gland (RPKM 3.8) and 17 other tissues See more Orthologs mouse all
PLCB1-IT1, Official Symbol PLCB1-IT1provided by HGNC Official Full Name PLCB1 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41414 See related Ensembl:ENSG00000225479 AllianceGenome:HGNC:41414 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PLCB2, Official Symbol PLCB2provided by HGNC Official Full Name phospholipase C beta 2provided by HGNC Primary source HGNC:HGNC:9055 See related Ensembl:ENSG00000137841 MIM:604114; AllianceGenome:HGNC:9055 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLC-beta-2 Summary The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017] Expression Broad expression in spleen (RPKM 26.9), bone marrow (RPKM 19.8) and 17 other tissues See more Orthologs mouse all
PLCB2-AS1, Official Symbol PLCB2-AS1provided by HGNC Official Full Name PLCB2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:43662 See related AllianceGenome:HGNC:43662 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
PLCB3, Official Symbol PLCB3provided by HGNC Official Full Name phospholipase C beta 3provided by HGNC Primary source HGNC:HGNC:9056 See related Ensembl:ENSG00000149782 MIM:600230; AllianceGenome:HGNC:9056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMDCD Summary This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Expression Broad expression in duodenum (RPKM 38.8), small intestine (RPKM 36.6) and 18 other tissues See more Orthologs mouse all
PLCB4, Official Symbol PLCB4provided by HGNC Official Full Name phospholipase C beta 4provided by HGNC Primary source HGNC:HGNC:9059 See related Ensembl:ENSG00000101333 MIM:600810; AllianceGenome:HGNC:9059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARCND2; PI-PLC; ARCND2A; ARCND2B Summary The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010] Expression Broad expression in thyroid (RPKM 7.9), salivary gland (RPKM 5.4) and 19 other tissues See more Orthologs mouse all
PLCD1, Official Symbol PLCD1provided by HGNC Official Full Name phospholipase C delta 1provided by HGNC Primary source HGNC:HGNC:9060 See related Ensembl:ENSG00000187091 MIM:602142; AllianceGenome:HGNC:9060 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDNC3; PLC-III Summary This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Broad expression in testis (RPKM 17.3), esophagus (RPKM 7.7) and 24 other tissues See more Orthologs mouse all
PLCD3, Official Symbol PLCD3provided by HGNC Official Full Name phospholipase C delta 3provided by HGNC Primary source HGNC:HGNC:9061 See related Ensembl:ENSG00000161714 MIM:608795; AllianceGenome:HGNC:9061 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLC-delta-3 Summary This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 22.8), urinary bladder (RPKM 21.5) and 20 other tissues See more Orthologs mouse all
PLCD4, Official Symbol PLCD4provided by HGNC Official Full Name phospholipase C delta 4provided by HGNC Primary source HGNC:HGNC:9062 See related Ensembl:ENSG00000115556 MIM:605939; AllianceGenome:HGNC:9062 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011] Expression Broad expression in esophagus (RPKM 2.6), testis (RPKM 2.2) and 23 other tissues See more Orthologs mouse all
PLCE1, Official Symbol PLCE1provided by HGNC Official Full Name phospholipase C epsilon 1provided by HGNC Primary source HGNC:HGNC:17175 See related Ensembl:ENSG00000138193 MIM:608414; AllianceGenome:HGNC:17175 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLCE; PPLC; NPHS3 Summary This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009] Expression Broad expression in colon (RPKM 6.3), endometrium (RPKM 5.5) and 21 other tissues See more Orthologs mouse all
PLCE1-AS1, Official Symbol PLCE1-AS1provided by HGNC Official Full Name PLCE1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:45193 See related Ensembl:ENSG00000268894 AllianceGenome:HGNC:45193 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in placenta (RPKM 2.0), endometrium (RPKM 1.2) and 21 other tissues See more
PLCE1-AS2, Official Symbol PLCE1-AS2provided by HGNC Official Full Name PLCE1 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:51206 See related Ensembl:ENSG00000232913 AllianceGenome:HGNC:51206 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PLCG1, Official Symbol PLCG1provided by HGNC Official Full Name phospholipase C gamma 1provided by HGNC Primary source HGNC:HGNC:9065 See related Ensembl:ENSG00000124181 MIM:172420; AllianceGenome:HGNC:9065 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1 Summary The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 23.5), lymph node (RPKM 23.2) and 25 other tissues See more Orthologs mouse all
PLCG1-AS1, Official Symbol PLCG1-AS1provided by HGNC Official Full Name PLCG1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40450 See related Ensembl:ENSG00000226648 AllianceGenome:HGNC:40450 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOP1-AS1 Expression Ubiquitous expression in lymph node (RPKM 5.4), appendix (RPKM 4.8) and 25 other tissues See more
PLCG2, Official Symbol PLCG2provided by HGNC Official Full Name phospholipase C gamma 2provided by HGNC Primary source HGNC:HGNC:9066 See related Ensembl:ENSG00000197943 MIM:600220; AllianceGenome:HGNC:9066 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FCAS3; APLAID; PLC-IV; PLC-gamma-2 Summary The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014] Expression Broad expression in lymph node (RPKM 20.0), spleen (RPKM 12.3) and 21 other tissues See more Orthologs mouse all
PLCH1, Official Symbol PLCH1provided by HGNC Official Full Name phospholipase C eta 1provided by HGNC Primary source HGNC:HGNC:29185 See related Ensembl:ENSG00000114805 MIM:612835; AllianceGenome:HGNC:29185 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPE14; PLCL3; PLC-L3; PLC eta 1 Summary PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009] Expression Biased expression in testis (RPKM 4.0), thyroid (RPKM 1.7) and 9 other tissues See more Orthologs mouse all
PLCH1-AS1, Official Symbol PLCH1-AS1provided by HGNC Official Full Name PLCH1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41231 See related Ensembl:ENSG00000239508 AllianceGenome:HGNC:41231 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PLCH1-AS2, Official Symbol PLCH1-AS2provided by HGNC Official Full Name PLCH1 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:41232 See related Ensembl:ENSG00000242925 AllianceGenome:HGNC:41232 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.4) See more
PLCH2, Official Symbol PLCH2provided by HGNC Official Full Name phospholipase C eta 2provided by HGNC Primary source HGNC:HGNC:29037 See related Ensembl:ENSG00000149527 MIM:612836; AllianceGenome:HGNC:29037 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLCL4; PLC-L4; PLCeta2; PLC-eta2 Summary PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009] Expression Biased expression in skin (RPKM 13.2), brain (RPKM 3.0) and 10 other tissues See more Orthologs mouse all
PLCL1, Official Symbol PLCL1provided by HGNC Official Full Name phospholipase C like 1 (inactive)provided by HGNC Primary source HGNC:HGNC:9063 See related Ensembl:ENSG00000115896 MIM:600597; AllianceGenome:HGNC:9063 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLCE; PLCL; PRIP; PLDL1; PPP1R127 Summary Predicted to enable phospholipase C activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including gamma-aminobutyric acid signaling pathway; regulation of GABAergic synaptic transmission; and regulation of peptidyl-serine phosphorylation. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 12.7), heart (RPKM 9.4) and 16 other tissues See more Orthologs mouse all
PLCL2, Official Symbol PLCL2provided by HGNC Official Full Name phospholipase C like 2provided by HGNC Primary source HGNC:HGNC:9064 See related Ensembl:ENSG00000154822 MIM:614276; AllianceGenome:HGNC:9064 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLCE2 Summary Enables GABA receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 4.0), lymph node (RPKM 3.4) and 23 other tissues See more Orthologs mouse all
PLCXD1, Official Symbol PLCXD1provided by HGNC Official Full Name phosphatidylinositol specific phospholipase C X domain containing 1provided by HGNC Primary source HGNC:HGNC:23148 See related Ensembl:ENSG00000182378 Ensembl:ENSG00000292344 MIM:300974; AllianceGenome:HGNC:23148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LL0XNC01-136G2.1 Summary This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in stomach (RPKM 5.3), skin (RPKM 4.4) and 25 other tissues See more Orthologs mouse all
PLCXD2, Official Symbol PLCXD2provided by HGNC Official Full Name phosphatidylinositol specific phospholipase C X domain containing 2provided by HGNC Primary source HGNC:HGNC:26462 See related Ensembl:ENSG00000240891 MIM:617015; AllianceGenome:HGNC:26462 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 2.6), liver (RPKM 2.6) and 21 other tissues See more Orthologs mouse all
PLCXD3, Official Symbol PLCXD3provided by HGNC Official Full Name phosphatidylinositol specific phospholipase C X domain containing 3provided by HGNC Primary source HGNC:HGNC:31822 See related Ensembl:ENSG00000182836 MIM:617016; AllianceGenome:HGNC:31822 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be located in cytoplasm. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in heart (RPKM 12.4), ovary (RPKM 9.3) and 8 other tissues See more Orthologs mouse all
PLCZ1, Official Symbol PLCZ1provided by HGNC Official Full Name phospholipase C zeta 1provided by HGNC Primary source HGNC:HGNC:19218 See related Ensembl:ENSG00000139151 MIM:608075; AllianceGenome:HGNC:19218 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPGF17; PLCzeta; NYD-SP27; PLC-zeta-1 Summary The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Restricted expression toward testis (RPKM 5.9) See more Orthologs mouse all