psui3905/ncbi_genes_summary huggingface dataset:
RNA5SP98, Official Symbol RNA5SP98provided by HGNC Official Full Name RNA, 5S ribosomal pseudogene 98provided by HGNC Primary source HGNC:HGNC:42896 See related Ensembl:ENSG00000200028 AllianceGenome:HGNC:42896 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RN5S98
RNA5SP99, Official Symbol RNA5SP99provided by HGNC Official Full Name RNA, 5S ribosomal pseudogene 99provided by HGNC Primary source HGNC:HGNC:42897 See related AllianceGenome:HGNC:42897 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RN5S99
RNASE1, Official Symbol RNASE1provided by HGNC Official Full Name ribonuclease A family member 1, pancreaticprovided by HGNC Primary source HGNC:HGNC:10044 See related Ensembl:ENSG00000129538 MIM:180440; AllianceGenome:HGNC:10044 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAC1; RIB1; RNS1 Summary This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in pancreas (RPKM 931.1), testis (RPKM 410.8) and 19 other tissues See more Orthologs mouse all
RNASE10, Official Symbol RNASE10provided by HGNC Official Full Name ribonuclease A family member 10 (inactive)provided by HGNC Primary source HGNC:HGNC:19275 See related Ensembl:ENSG00000182545 AllianceGenome:HGNC:19275 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAH1; RNASE9 Summary Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including heterotypic cell-cell adhesion; positive regulation of flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
RNASE11, Official Symbol RNASE11provided by HGNC Official Full Name ribonuclease A family member 11 (inactive)provided by HGNC Primary source HGNC:HGNC:19269 See related Ensembl:ENSG00000173464 AllianceGenome:HGNC:19269 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAJ1; C14orf6; HEL-S-84p Summary Predicted to enable endonuclease activity and nucleic acid binding activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 14.1) See more Orthologs mouse all
RNASE12, Official Symbol RNASE12provided by HGNC Official Full Name ribonuclease A family member 12 (inactive)provided by HGNC Primary source HGNC:HGNC:24211 See related Ensembl:ENSG00000258436 AllianceGenome:HGNC:24211 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAI1; HEL-S-85p Summary Predicted to enable nucleic acid binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
RNASE13, Official Symbol RNASE13provided by HGNC Official Full Name ribonuclease A family member 13 (inactive)provided by HGNC Primary source HGNC:HGNC:25285 See related Ensembl:ENSG00000206150 AllianceGenome:HGNC:25285 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAL1; HEL-S-86p Summary Predicted to enable nucleic acid binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
RNASE2, Official Symbol RNASE2provided by HGNC Official Full Name ribonuclease A family member 2provided by HGNC Primary source HGNC:HGNC:10045 See related Ensembl:ENSG00000169385 MIM:131410; AllianceGenome:HGNC:10045 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDN; RAF3; RNS2 Summary The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014] Expression Restricted expression toward bone marrow (RPKM 516.0) See more Orthologs mouse all
RNASE3, Official Symbol RNASE3provided by HGNC Official Full Name ribonuclease A family member 3provided by HGNC Primary source HGNC:HGNC:10046 See related Ensembl:ENSG00000169397 MIM:131398; AllianceGenome:HGNC:10046 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ECP; RAF1; RNS3 Summary The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014] Expression Restricted expression toward bone marrow (RPKM 299.8) See more Orthologs all
RNASE4, Official Symbol RNASE4provided by HGNC Official Full Name ribonuclease A family member 4provided by HGNC Primary source HGNC:HGNC:10047 See related Ensembl:ENSG00000258818 MIM:601030; AllianceGenome:HGNC:10047 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAB1; RNS4 Summary The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013] Expression Biased expression in liver (RPKM 129.2), fat (RPKM 38.7) and 12 other tissues See more Orthologs mouse all
RNASE6, Official Symbol RNASE6provided by HGNC Official Full Name ribonuclease A family member k6provided by HGNC Primary source HGNC:HGNC:10048 See related Ensembl:ENSG00000169413 MIM:601981; AllianceGenome:HGNC:10048 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAD1; RNS6; RNasek6 Summary The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014] Expression Broad expression in lymph node (RPKM 33.5), appendix (RPKM 26.6) and 24 other tissues See more Orthologs mouse all
RNASE7, Official Symbol RNASE7provided by HGNC Official Full Name ribonuclease A family member 7provided by HGNC Primary source HGNC:HGNC:19278 See related Ensembl:ENSG00000165799 MIM:612484; AllianceGenome:HGNC:19278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAE1 Summary The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] Expression Biased expression in esophagus (RPKM 35.9), skin (RPKM 11.5) and 1 other tissue See more Orthologs all
RNASE8, Official Symbol RNASE8provided by HGNC Official Full Name ribonuclease A family member 8provided by HGNC Primary source HGNC:HGNC:19277 See related Ensembl:ENSG00000173431 MIM:612485; AllianceGenome:HGNC:19277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAE2 Summary The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014] Orthologs all
RNASE9, Official Symbol RNASE9provided by HGNC Official Full Name ribonuclease A family member 9 (inactive)provided by HGNC Primary source HGNC:HGNC:20673 See related Ensembl:ENSG00000188655 MIM:614014; AllianceGenome:HGNC:20673 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAK1; h461; HEL128 Summary Predicted to enable nucleic acid binding activity. Predicted to act upstream of or within positive regulation of flagellated sperm motility involved in capacitation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
RNASEH1, Official Symbol RNASEH1provided by HGNC Official Full Name ribonuclease H1provided by HGNC Primary source HGNC:HGNC:18466 See related Ensembl:ENSG00000171865 MIM:604123; AllianceGenome:HGNC:18466 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNH1; H1RNA; PEOB2 Summary This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017] Expression Ubiquitous expression in brain (RPKM 5.7), endometrium (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
RNASEH1P1, Official Symbol RNASEH1P1provided by HGNC Official Full Name ribonuclease H1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:10049 See related Ensembl:ENSG00000265790 AllianceGenome:HGNC:10049 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNH1; RNASEH1; RNASEH1P
RNASEH1P2, Official Symbol RNASEH1P2provided by HGNC Official Full Name ribonuclease H1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:18715 See related Ensembl:ENSG00000231458 AllianceGenome:HGNC:18715 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNASEH2A, Official Symbol RNASEH2Aprovided by HGNC Official Full Name ribonuclease H2 subunit Aprovided by HGNC Primary source HGNC:HGNC:18518 See related Ensembl:ENSG00000104889 MIM:606034; AllianceGenome:HGNC:18518 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGS4; JUNB; RNHL; RNHIA; THSD8; RNASEHI Summary The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009] Expression Ubiquitous expression in bone marrow (RPKM 7.3), testis (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
RNASEH2B, Official Symbol RNASEH2Bprovided by HGNC Official Full Name ribonuclease H2 subunit Bprovided by HGNC Primary source HGNC:HGNC:25671 See related Ensembl:ENSG00000136104 MIM:610326; AllianceGenome:HGNC:25671 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGS2; DLEU8 Summary RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in bone marrow (RPKM 7.7), lymph node (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
RNASEH2C, Official Symbol RNASEH2Cprovided by HGNC Official Full Name ribonuclease H2 subunit Cprovided by HGNC Primary source HGNC:HGNC:24116 See related Ensembl:ENSG00000172922 MIM:610330; AllianceGenome:HGNC:24116 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AGS3; AYP1 Summary This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 17.9), endometrium (RPKM 15.2) and 25 other tissues See more Orthologs mouse all
RNASEK, Official Symbol RNASEKprovided by HGNC Official Full Name ribonuclease Kprovided by HGNC Primary source HGNC:HGNC:33911 See related Ensembl:ENSG00000219200 MIM:617098; AllianceGenome:HGNC:33911 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables endoribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 84.0), kidney (RPKM 67.2) and 25 other tissues See more Orthologs mouse all
RNASEK-C17orf49, Official Symbol RNASEK-C17orf49provided by HGNC Official Full Name RNASEK-C17orf49 readthroughprovided by HGNC Primary source HGNC:HGNC:44419 See related Ensembl:ENSG00000161939 AllianceGenome:HGNC:44419 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAP18; C17orf49 Summary This locus represents naturally occurring read-through transcription between the neighboring RNASEK (ribonuclease, RNase K) and C17orf49 (chromosome 17 open reading frame 49) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is unlikely to produce a protein product. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in adrenal (RPKM 51.3), spleen (RPKM 48.8) and 25 other tissues See more
RNASEL, Official Symbol RNASELprovided by HGNC Official Full Name ribonuclease Lprovided by HGNC Primary source HGNC:HGNC:10050 See related Ensembl:ENSG00000135828 MIM:180435; AllianceGenome:HGNC:10050 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNS4; PRCA1 Summary This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in thyroid (RPKM 5.0), ovary (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
RNASET2, Official Symbol RNASET2provided by HGNC Official Full Name ribonuclease T2provided by HGNC Primary source HGNC:HGNC:21686 See related Ensembl:ENSG00000026297 MIM:612944; AllianceGenome:HGNC:21686 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNASE6PL; bA514O12.3 Summary This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 93.0), colon (RPKM 39.0) and 24 other tissues See more Orthologs mouse all
RND1, Official Symbol RND1provided by HGNC Official Full Name Rho family GTPase 1provided by HGNC Primary source HGNC:HGNC:18314 See related Ensembl:ENSG00000172602 MIM:609038; AllianceGenome:HGNC:18314 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARHS; RHO6; RHOS Summary This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014] Expression Biased expression in liver (RPKM 28.4), brain (RPKM 15.0) and 9 other tissues See more Orthologs mouse all
RND2, Official Symbol RND2provided by HGNC Official Full Name Rho family GTPase 2provided by HGNC Primary source HGNC:HGNC:18315 See related Ensembl:ENSG00000108830 MIM:601555; AllianceGenome:HGNC:18315 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARHN; RHO7; RhoN Summary This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 14.7), testis (RPKM 13.8) and 5 other tissues See more Orthologs mouse all
RND3, Official Symbol RND3provided by HGNC Official Full Name Rho family GTPase 3provided by HGNC Primary source HGNC:HGNC:671 See related Ensembl:ENSG00000115963 MIM:602924; AllianceGenome:HGNC:671 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARHE; Rho8; RhoE; memB Summary This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] Expression Broad expression in esophagus (RPKM 87.1), liver (RPKM 49.1) and 19 other tissues See more Orthologs mouse all
RNF10, Official Symbol RNF10provided by HGNC Official Full Name ring finger protein 10provided by HGNC Primary source HGNC:HGNC:10055 See related Ensembl:ENSG00000022840 MIM:615998; AllianceGenome:HGNC:10055 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIE2 Summary The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 52.4), bone marrow (RPKM 51.8) and 25 other tissues See more Orthologs mouse all
RNF103, Official Symbol RNF103provided by HGNC Official Full Name ring finger protein 103provided by HGNC Primary source HGNC:HGNC:12859 See related Ensembl:ENSG00000239305 MIM:602507; AllianceGenome:HGNC:12859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KF1; KF-1; HKF-1; ZFP103; ZFP-103 Summary The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in bone marrow (RPKM 15.1), small intestine (RPKM 12.4) and 25 other tissues See more Orthologs mouse all
RNF103-CHMP3, Official Symbol RNF103-CHMP3provided by HGNC Official Full Name RNF103-CHMP3 readthroughprovided by HGNC Primary source HGNC:HGNC:38847 See related Ensembl:ENSG00000249884 AllianceGenome:HGNC:38847 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEDF; CHMP3; VPS24; CGI149; hVps24; RNF103-VPS24 Summary This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in esophagus (RPKM 39.0), thyroid (RPKM 37.6) and 25 other tissues See more Orthologs all
RNF10P1, Official Symbol RNF10P1provided by HGNC Official Full Name ring finger protein 10 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44472 See related AllianceGenome:HGNC:44472 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNF11, Official Symbol RNF11provided by HGNC Official Full Name ring finger protein 11provided by HGNC Primary source HGNC:HGNC:10056 See related Ensembl:ENSG00000123091 MIM:612598; AllianceGenome:HGNC:10056 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-123; SID1669 Summary The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 55.4) and 25 other tissues See more Orthologs mouse all
RNF111, Official Symbol RNF111provided by HGNC Official Full Name ring finger protein 111provided by HGNC Primary source HGNC:HGNC:17384 See related Ensembl:ENSG00000157450 MIM:605840; AllianceGenome:HGNC:17384 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARK; hRNF111 Summary The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 5.8), brain (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
RNF112, Official Symbol RNF112provided by HGNC Official Full Name ring finger protein 112provided by HGNC Primary source HGNC:HGNC:12968 See related Ensembl:ENSG00000128482 MIM:601237; AllianceGenome:HGNC:12968 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BFP; ZNF179 Summary This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 6.0), prostate (RPKM 2.1) and 11 other tissues See more Orthologs mouse all
RNF113A, Official Symbol RNF113Aprovided by HGNC Official Full Name ring finger protein 113Aprovided by HGNC Primary source HGNC:HGNC:12974 See related Ensembl:ENSG00000125352 MIM:300951; AllianceGenome:HGNC:12974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTD5; Cwc24; RNF113; ZNF183 Summary This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010] Orthologs mouse all
RNF113B, Official Symbol RNF113Bprovided by HGNC Official Full Name ring finger protein 113Bprovided by HGNC Primary source HGNC:HGNC:17267 See related Ensembl:ENSG00000139797 AllianceGenome:HGNC:17267 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF161; ZNF183L1; bA10G5.1 Summary Predicted to enable metal ion binding activity. Predicted to be involved in snoRNA splicing. Predicted to be part of U2-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 23.9) See more Orthologs all
RNF114, Official Symbol RNF114provided by HGNC Official Full Name ring finger protein 114provided by HGNC Primary source HGNC:HGNC:13094 See related Ensembl:ENSG00000124226 MIM:612451; AllianceGenome:HGNC:13094 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF313; PSORS12 Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 40.7), spleen (RPKM 29.3) and 25 other tissues See more Orthologs mouse all
RNF115, Official Symbol RNF115provided by HGNC Official Full Name ring finger protein 115provided by HGNC Primary source HGNC:HGNC:18154 See related Ensembl:ENSG00000265491 MIM:619535; AllianceGenome:HGNC:18154 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCA2; ZFP364; ZNF364; RABRING7 Summary Enables ubiquitin-protein transferase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; protein autoubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 16.1), fat (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
RNF121, Official Symbol RNF121provided by HGNC Official Full Name ring finger protein 121provided by HGNC Primary source HGNC:HGNC:21070 See related Ensembl:ENSG00000137522 AllianceGenome:HGNC:21070 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in kidney (RPKM 7.3), thyroid (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
RNF122, Official Symbol RNF122provided by HGNC Official Full Name ring finger protein 122provided by HGNC Primary source HGNC:HGNC:21147 See related Ensembl:ENSG00000133874 AllianceGenome:HGNC:21147 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in gall bladder (RPKM 7.2), adrenal (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
RNF123, Official Symbol RNF123provided by HGNC Official Full Name ring finger protein 123provided by HGNC Primary source HGNC:HGNC:21148 See related Ensembl:ENSG00000164068 MIM:614472; AllianceGenome:HGNC:21148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KPC1; FP1477 Summary The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in bone marrow (RPKM 13.6), testis (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
RNF125, Official Symbol RNF125provided by HGNC Official Full Name ring finger protein 125provided by HGNC Primary source HGNC:HGNC:21150 See related Ensembl:ENSG00000101695 MIM:610432; AllianceGenome:HGNC:21150 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TNORS; TRAC1; TRAC-1 Summary This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in fat (RPKM 4.1), bone marrow (RPKM 4.0) and 25 other tissues See more Orthologs mouse all
RNF126, Official Symbol RNF126provided by HGNC Official Full Name ring finger protein 126provided by HGNC Primary source HGNC:HGNC:21151 See related Ensembl:ENSG00000070423 MIM:615177; AllianceGenome:HGNC:21151 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 15.1), spleen (RPKM 11.1) and 25 other tissues See more Orthologs mouse all
RNF126P1, Official Symbol RNF126P1provided by HGNC Official Full Name ring finger protein 126 pseudogene 1provided by HGNC Primary source HGNC:HGNC:30340 See related Ensembl:ENSG00000261192 AllianceGenome:HGNC:30340 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNF128, Official Symbol RNF128provided by HGNC Official Full Name ring finger protein 128provided by HGNC Primary source HGNC:HGNC:21153 See related Ensembl:ENSG00000133135 MIM:300439; AllianceGenome:HGNC:21153 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRAIL Summary The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Broad expression in small intestine (RPKM 27.8), liver (RPKM 27.8) and 15 other tissues See more Orthologs mouse all
RNF13, Official Symbol RNF13provided by HGNC Official Full Name ring finger protein 13provided by HGNC Primary source HGNC:HGNC:10057 See related Ensembl:ENSG00000082996 MIM:609247; AllianceGenome:HGNC:10057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RZF; DEE73; EIEE73 Summary The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 22.1), brain (RPKM 22.0) and 25 other tissues See more Orthologs mouse all
RNF130, Official Symbol RNF130provided by HGNC Official Full Name ring finger protein 130provided by HGNC Primary source HGNC:HGNC:18280 See related Ensembl:ENSG00000113269 MIM:619163; AllianceGenome:HGNC:18280 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP; G1RP; G1RZFP; GOLIATH Summary The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in fat (RPKM 11.3), brain (RPKM 9.7) and 25 other tissues See more Orthologs mouse all
RNF133, Official Symbol RNF133provided by HGNC Official Full Name ring finger protein 133provided by HGNC Primary source HGNC:HGNC:21154 See related Ensembl:ENSG00000188050 AllianceGenome:HGNC:21154 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. [provided by RefSeq, Jul 2008] Orthologs mouse all
RNF135, Official Symbol RNF135provided by HGNC Official Full Name ring finger protein 135provided by HGNC Primary source HGNC:HGNC:21158 See related Ensembl:ENSG00000181481 MIM:611358; AllianceGenome:HGNC:21158 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L13; MMFD; REUL; Riplet Summary The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 5.5), spleen (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
RNF138, Official Symbol RNF138provided by HGNC Official Full Name ring finger protein 138provided by HGNC Primary source HGNC:HGNC:17765 See related Ensembl:ENSG00000134758 MIM:616319; AllianceGenome:HGNC:17765 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NARF; HSD-4; STRIN; hNARF Summary The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 31.9), bone marrow (RPKM 30.7) and 23 other tissues See more Orthologs mouse all
RNF138P1, Official Symbol RNF138P1provided by HGNC Official Full Name ring finger protein 138 pseudogene 1provided by HGNC Primary source HGNC:HGNC:30342 See related AllianceGenome:HGNC:30342 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNF138P2, Official Symbol RNF138P2provided by HGNC Official Full Name ring finger protein 138 pseudogene 2provided by HGNC Primary source HGNC:HGNC:50775 See related Ensembl:ENSG00000271194 AllianceGenome:HGNC:50775 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNF139, Official Symbol RNF139provided by HGNC Official Full Name ring finger protein 139provided by HGNC Primary source HGNC:HGNC:17023 See related Ensembl:ENSG00000170881 MIM:603046; AllianceGenome:HGNC:17023 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RCA1; TRC8; HRCA1 Summary The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 33.6), testis (RPKM 25.9) and 25 other tissues See more Orthologs mouse all
RNF14, Official Symbol RNF14provided by HGNC Official Full Name ring finger protein 14provided by HGNC Primary source HGNC:HGNC:10058 See related Ensembl:ENSG00000013561 MIM:605675; AllianceGenome:HGNC:10058 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARA54; HFB30; TRIAD2; HRIHFB2038 Summary The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues See more Orthologs mouse all