psui3905/ncbi_genes_summary huggingface dataset:
FSCN3, Official Symbol FSCN3provided by HGNC Official Full Name fascin actin-bundling protein 3provided by HGNC Primary source HGNC:HGNC:3961 See related Ensembl:ENSG00000106328 MIM:615800; AllianceGenome:HGNC:3961 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including lamellipodium; microvillus; and ruffle. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 43.5) See more Orthologs mouse all
FSD1, Official Symbol FSD1provided by HGNC Official Full Name fibronectin type III and SPRY domain containing 1provided by HGNC Primary source HGNC:HGNC:13745 See related Ensembl:ENSG00000105255 MIM:609828; AllianceGenome:HGNC:13745 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIR1; GLFND Summary This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009] Expression Biased expression in brain (RPKM 10.1), testis (RPKM 4.8) and 2 other tissues See more Orthologs mouse all
FSD1L, Official Symbol FSD1Lprovided by HGNC Official Full Name fibronectin type III and SPRY domain containing 1 likeprovided by HGNC Primary source HGNC:HGNC:13753 See related Ensembl:ENSG00000106701 MIM:609829; AllianceGenome:HGNC:13753 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIR1; CCDC10; FSD1CL; FSD1NL; CSDUFD1 Summary Predicted to be located in cytoplasm. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 4.1), testis (RPKM 1.7) and 22 other tissues See more Orthologs mouse all
FSD2, Official Symbol FSD2provided by HGNC Official Full Name fibronectin type III and SPRY domain containing 2provided by HGNC Primary source HGNC:HGNC:18024 See related Ensembl:ENSG00000186628 AllianceGenome:HGNC:18024 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPRYD1 Summary This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Biased expression in heart (RPKM 7.7), prostate (RPKM 0.9) and 6 other tissues See more Orthologs mouse all
FSHB, Official Symbol FSHBprovided by HGNC Official Full Name follicle stimulating hormone subunit betaprovided by HGNC Primary source HGNC:HGNC:3964 See related Ensembl:ENSG00000131808 MIM:136530; AllianceGenome:HGNC:3964 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HH24 Summary The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
FSHR, Official Symbol FSHRprovided by HGNC Official Full Name follicle stimulating hormone receptorprovided by HGNC Primary source HGNC:HGNC:3969 See related Ensembl:ENSG00000170820 MIM:136435; AllianceGenome:HGNC:3969 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LGR1; ODG1; FSHR1; FSHRO Summary The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
FSIP1, Official Symbol FSIP1provided by HGNC Official Full Name fibrous sheath interacting protein 1provided by HGNC Primary source HGNC:HGNC:21674 See related Ensembl:ENSG00000150667 MIM:615795; AllianceGenome:HGNC:21674 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSD10 Expression Biased expression in appendix (RPKM 7.4), bone marrow (RPKM 3.4) and 11 other tissues See more Orthologs mouse all
FSIP2, Official Symbol FSIP2provided by HGNC Official Full Name fibrous sheath interacting protein 2provided by HGNC Primary source HGNC:HGNC:21675 See related Ensembl:ENSG00000188738 MIM:615796; AllianceGenome:HGNC:21675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPGF34 Summary This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016] Expression Biased expression in testis (RPKM 4.0), stomach (RPKM 1.4) and 2 other tissues See more Orthologs mouse all
FSIP2-AS1, Official Symbol FSIP2-AS1provided by HGNC Official Full Name FSIP2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40978 See related Ensembl:ENSG00000231646 AllianceGenome:HGNC:40978 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 2.0), stomach (RPKM 1.0) and 12 other tissues See more
FSIP2-AS2, Official Symbol FSIP2-AS2provided by HGNC Official Full Name FSIP2 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:54061 See related Ensembl:ENSG00000226747 AllianceGenome:HGNC:54061 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 3.3) and skin (RPKM 0.2) See more
FST, Official Symbol FSTprovided by HGNC Official Full Name follistatinprovided by HGNC Primary source HGNC:HGNC:3971 See related Ensembl:ENSG00000134363 MIM:136470; AllianceGenome:HGNC:3971 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FS Summary Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 13.6), placenta (RPKM 7.9) and 16 other tissues See more Orthologs mouse all
FSTL1, Official Symbol FSTL1provided by HGNC Official Full Name follistatin like 1provided by HGNC Primary source HGNC:HGNC:3972 See related Ensembl:ENSG00000163430 MIM:605547; AllianceGenome:HGNC:3972 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRP; FSL1; OCC1; OCC-1; tsc36; MIR198 Summary This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 238.4), gall bladder (RPKM 177.0) and 21 other tissues See more Orthologs mouse all
FSTL3, Official Symbol FSTL3provided by HGNC Official Full Name follistatin like 3provided by HGNC Primary source HGNC:HGNC:3973 See related Ensembl:ENSG00000070404 MIM:605343; AllianceGenome:HGNC:3973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLRG; FSRP Summary Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 92.4), testis (RPKM 32.9) and 13 other tissues See more Orthologs mouse all
FSTL4, Official Symbol FSTL4provided by HGNC Official Full Name follistatin like 4provided by HGNC Primary source HGNC:HGNC:21389 See related Ensembl:ENSG00000053108 AllianceGenome:HGNC:21389 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable brain-derived neurotrophic factor binding activity and calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to act upstream of or within negative regulation of brain-derived neurotrophic factor receptor signaling pathway; negative regulation of collateral sprouting; and negative regulation of dendritic spine development. Predicted to be located in extracellular region and secretory granule. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 2.5), urinary bladder (RPKM 1.7) and 8 other tissues See more Orthologs mouse all
FSTL5, Official Symbol FSTL5provided by HGNC Official Full Name follistatin like 5provided by HGNC Primary source HGNC:HGNC:21386 See related Ensembl:ENSG00000168843 MIM:620128; AllianceGenome:HGNC:21386 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 6.2), adrenal (RPKM 3.7) and 1 other tissue See more Orthologs mouse all
FTCD, Official Symbol FTCDprovided by HGNC Official Full Name formimidoyltransferase cyclodeaminaseprovided by HGNC Primary source HGNC:HGNC:3974 See related Ensembl:ENSG00000160282 MIM:606806; AllianceGenome:HGNC:3974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCHC1 Summary The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009] Expression Biased expression in liver (RPKM 54.7), kidney (RPKM 35.5) and 1 other tissue See more Orthologs mouse all
FTCD-AS1, Official Symbol FTCD-AS1provided by HGNC Official Full Name FTCD antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40243 See related Ensembl:ENSG00000237338 AllianceGenome:HGNC:40243 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTCDNL1, Official Symbol FTCDNL1provided by HGNC Official Full Name formiminotransferase cyclodeaminase N-terminal likeprovided by HGNC Primary source HGNC:HGNC:48661 See related Ensembl:ENSG00000226124 MIM:614308; AllianceGenome:HGNC:48661 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FONG Summary Predicted to enable folic acid binding activity and transferase activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 1.7), thyroid (RPKM 1.3) and 25 other tissues See more Orthologs all
FTH1, Official Symbol FTH1provided by HGNC Official Full Name ferritin heavy chain 1provided by HGNC Primary source HGNC:HGNC:3976 See related Ensembl:ENSG00000167996 MIM:134770; AllianceGenome:HGNC:3976 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHC; FTH; HFE5; PLIF; FTHL6; PIG15 Summary This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in colon (RPKM 1259.0), appendix (RPKM 1256.9) and 25 other tissues See more Orthologs mouse all
FTH1P10, Official Symbol FTH1P10provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 10provided by HGNC Primary source HGNC:HGNC:3980 See related Ensembl:ENSG00000223361 AllianceGenome:HGNC:3980 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTHL10
FTH1P16, Official Symbol FTH1P16provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 16provided by HGNC Primary source HGNC:HGNC:3986 See related AllianceGenome:HGNC:3986 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTH2; FTHL16
FTH1P22, Official Symbol FTH1P22provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 22provided by HGNC Primary source HGNC:HGNC:37640 See related Ensembl:ENSG00000225079 AllianceGenome:HGNC:37640 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTHL22
FTH1P25, Official Symbol FTH1P25provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 25provided by HGNC Primary source HGNC:HGNC:37643 See related Ensembl:ENSG00000232792 AllianceGenome:HGNC:37643 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTHL25
FTH1P26, Official Symbol FTH1P26provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 26provided by HGNC Primary source HGNC:HGNC:37644 See related AllianceGenome:HGNC:37644 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTHL26
FTH1P5, Official Symbol FTH1P5provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:3996 See related AllianceGenome:HGNC:3996 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTHL5; FTHP1
FTH1P6, Official Symbol FTH1P6provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 6provided by HGNC Primary source HGNC:HGNC:39088 See related Ensembl:ENSG00000233083 AllianceGenome:HGNC:39088 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTH1P9, Official Symbol FTH1P9provided by HGNC Official Full Name ferritin heavy chain 1 pseudogene 9provided by HGNC Primary source HGNC:HGNC:39089 See related Ensembl:ENSG00000251395 AllianceGenome:HGNC:39089 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTHL17, Official Symbol FTHL17provided by HGNC Official Full Name ferritin heavy chain like 17provided by HGNC Primary source HGNC:HGNC:3987 See related Ensembl:ENSG00000132446 MIM:300308; AllianceGenome:HGNC:3987 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT38 Summary This gene encodes a ferritin heavy chain-like protein. This gene is primarily expressed in embryonic germ cells. The encoded protein may lack ferroxidase activity. Multiple pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Oct 2016] Orthologs mouse all
FTL, Official Symbol FTLprovided by HGNC Official Full Name ferritin light chainprovided by HGNC Primary source HGNC:HGNC:3999 See related Ensembl:ENSG00000087086 MIM:134790; AllianceGenome:HGNC:3999 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FTL1; LFTD; NBIA3 Summary This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 2442.6), spleen (RPKM 2174.9) and 25 other tissues See more Orthologs mouse all
FTLP10, Official Symbol FTLP10provided by HGNC Official Full Name ferritin light chain pseudogene 10provided by HGNC Primary source HGNC:HGNC:37959 See related Ensembl:ENSG00000250426 AllianceGenome:HGNC:37959 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FTLP12, Official Symbol FTLP12provided by HGNC Official Full Name ferritin light chain pseudogene 12provided by HGNC Primary source HGNC:HGNC:37961 See related Ensembl:ENSG00000265095 AllianceGenome:HGNC:37961 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTLP13, Official Symbol FTLP13provided by HGNC Official Full Name ferritin light chain pseudogene 13provided by HGNC Primary source HGNC:HGNC:37963 See related Ensembl:ENSG00000263725 AllianceGenome:HGNC:37963 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTLP15, Official Symbol FTLP15provided by HGNC Official Full Name ferritin light chain pseudogene 15provided by HGNC Primary source HGNC:HGNC:37965 See related AllianceGenome:HGNC:37965 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTLP16, Official Symbol FTLP16provided by HGNC Official Full Name ferritin light chain pseudogene 16provided by HGNC Primary source HGNC:HGNC:37966 See related Ensembl:ENSG00000229735 AllianceGenome:HGNC:37966 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTLP18, Official Symbol FTLP18provided by HGNC Official Full Name ferritin light chain pseudogene 18provided by HGNC Primary source HGNC:HGNC:37968 See related Ensembl:ENSG00000230214 AllianceGenome:HGNC:37968 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTLP19, Official Symbol FTLP19provided by HGNC Official Full Name ferritin light chain pseudogene 19provided by HGNC Primary source HGNC:HGNC:37969 See related Ensembl:ENSG00000237913 AllianceGenome:HGNC:37969 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTLP8, Official Symbol FTLP8provided by HGNC Official Full Name ferritin light chain pseudogene 8provided by HGNC Primary source HGNC:HGNC:37956 See related Ensembl:ENSG00000232217 AllianceGenome:HGNC:37956 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FTMT, Official Symbol FTMTprovided by HGNC Official Full Name ferritin mitochondrialprovided by HGNC Primary source HGNC:HGNC:17345 See related Ensembl:ENSG00000181867 MIM:608847; AllianceGenome:HGNC:17345 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTF Summary Predicted to enable ferric iron binding activity and ferrous iron binding activity. Involved in several processes, including cellular iron ion homeostasis; positive regulation of aconitate hydratase activity; and positive regulation of succinate dehydrogenase activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
FTO, Official Symbol FTOprovided by HGNC Official Full Name FTO alpha-ketoglutarate dependent dioxygenaseprovided by HGNC Primary source HGNC:HGNC:24678 See related Ensembl:ENSG00000140718 MIM:610966; AllianceGenome:HGNC:24678 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDFD; IFEX9; ALKBH9; BMIQ14 Summary This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011] Expression Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.2) and 25 other tissues See more Orthologs mouse all
FTSJ1, Official Symbol FTSJ1provided by HGNC Official Full Name FtsJ RNA 2'-O-methyltransferase 1provided by HGNC Primary source HGNC:HGNC:13254 See related Ensembl:ENSG00000068438 MIM:300499; AllianceGenome:HGNC:13254 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JM23; MRX9; SPB1; CDLIV; MRX44; TRMT7; XLID9 Summary This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in thyroid (RPKM 9.6), appendix (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
FTSJ3, Official Symbol FTSJ3provided by HGNC Official Full Name FtsJ RNA 2'-O-methyltransferase 3provided by HGNC Primary source HGNC:HGNC:17136 See related Ensembl:ENSG00000108592 MIM:618411; AllianceGenome:HGNC:17136 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPB1; EPCS3 Summary Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 14.7), lymph node (RPKM 12.1) and 25 other tissues See more Orthologs mouse all
FTX, Official Symbol FTXprovided by HGNC Official Full Name FTX transcript, XIST regulatorprovided by HGNC Primary source HGNC:HGNC:37190 See related Ensembl:ENSG00000230590 MIM:300936; AllianceGenome:HGNC:37190 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00182; MIR374AHG; NCRNA00182 Summary This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015] Expression Ubiquitous expression in ovary (RPKM 3.1), thyroid (RPKM 2.1) and 25 other tissues See more Orthologs mouse all
FUBP1, Official Symbol FUBP1provided by HGNC Official Full Name far upstream element binding protein 1provided by HGNC Primary source HGNC:HGNC:4004 See related Ensembl:ENSG00000162613 MIM:603444; AllianceGenome:HGNC:4004 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBP; FUBP; hDH V Summary The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 20.3) and 25 other tissues See more Orthologs mouse all
FUBP3, Official Symbol FUBP3provided by HGNC Official Full Name far upstream element binding protein 3provided by HGNC Primary source HGNC:HGNC:4005 See related Ensembl:ENSG00000107164 MIM:603536; AllianceGenome:HGNC:4005 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FBP3 Summary Enables single-stranded DNA binding activity. Involved in positive regulation of gene expression; positive regulation of transcription, DNA-templated; and transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 11.3) and 25 other tissues See more Orthologs mouse all
FUCA1, Official Symbol FUCA1provided by HGNC Official Full Name alpha-L-fucosidase 1provided by HGNC Primary source HGNC:HGNC:4006 See related Ensembl:ENSG00000179163 MIM:612280; AllianceGenome:HGNC:4006 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUCA Summary The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009] Expression Broad expression in lymph node (RPKM 70.6), colon (RPKM 56.5) and 23 other tissues See more Orthologs mouse all
FUCA2, Official Symbol FUCA2provided by HGNC Official Full Name alpha-L-fucosidase 2provided by HGNC Primary source HGNC:HGNC:4008 See related Ensembl:ENSG00000001036 MIM:136820; AllianceGenome:HGNC:4008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ20N2.5 Summary This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in placenta (RPKM 24.8), colon (RPKM 24.3) and 25 other tissues See more Orthologs mouse all
FUNDC1, Official Symbol FUNDC1provided by HGNC Official Full Name FUN14 domain containing 1provided by HGNC Primary source HGNC:HGNC:28746 See related Ensembl:ENSG00000069509 MIM:300871; AllianceGenome:HGNC:28746 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in brain (RPKM 11.4), heart (RPKM 11.0) and 25 other tissues See more Orthologs mouse all
FUNDC2, Official Symbol FUNDC2provided by HGNC Official Full Name FUN14 domain containing 2provided by HGNC Primary source HGNC:HGNC:24925 See related Ensembl:ENSG00000165775 MIM:301042; AllianceGenome:HGNC:24925 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DC44; HCC3; HCBP6; PD03104 Summary Predicted to be involved in autophagy of mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 26.0), ovary (RPKM 19.3) and 25 other tissues See more Orthologs mouse all
FUNDC2P1, Official Symbol FUNDC2P1provided by HGNC Official Full Name FUN14 domain containing 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:17253 See related AllianceGenome:HGNC:17253 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUNDC2P
FUNDC2P4, Official Symbol FUNDC2P4provided by HGNC Official Full Name FUN14 domain containing 2 pseudogene 4provided by HGNC Primary source HGNC:HGNC:37971 See related AllianceGenome:HGNC:37971 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FUOM, Official Symbol FUOMprovided by HGNC Official Full Name fucose mutarotaseprovided by HGNC Primary source HGNC:HGNC:24733 See related Ensembl:ENSG00000148803 MIM:617725; AllianceGenome:HGNC:24733 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUCU; FucM; C10orf125 Summary Predicted to enable L-fucose mutarotase activity and fucose binding activity. Predicted to be involved in fucose metabolic process and fucosylation. Predicted to act upstream of or within female mating behavior and negative regulation of neuron differentiation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in liver (RPKM 9.1), duodenum (RPKM 5.8) and 21 other tissues See more Orthologs mouse all
FURIN, Official Symbol FURINprovided by HGNC Official Full Name furin, paired basic amino acid cleaving enzymeprovided by HGNC Primary source HGNC:HGNC:8568 See related Ensembl:ENSG00000140564 MIM:136950; AllianceGenome:HGNC:8568 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUR; PACE; SPC1; PCSK3 Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Ubiquitous expression in salivary gland (RPKM 50.5), liver (RPKM 36.0) and 25 other tissues See more Orthologs mouse all
FUS, Official Symbol FUSprovided by HGNC Official Full Name FUS RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:4010 See related Ensembl:ENSG00000089280 MIM:137070; AllianceGenome:HGNC:4010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLS; ALS6; ETM4; FUS1; POMP75; altFUS; HNRNPP2 Summary This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in appendix (RPKM 32.4), lymph node (RPKM 29.5) and 25 other tissues See more Orthologs mouse all
FUT1, Official Symbol FUT1provided by HGNC Official Full Name fucosyltransferase 1 (H blood group)provided by HGNC Primary source HGNC:HGNC:4012 See related Ensembl:ENSG00000174951 MIM:211100; AllianceGenome:HGNC:4012 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H; HH; HSC Summary This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016] Expression Broad expression in stomach (RPKM 2.7), pancreas (RPKM 2.4) and 23 other tissues See more Orthologs mouse all
FUT10, Official Symbol FUT10provided by HGNC Official Full Name fucosyltransferase 10provided by HGNC Primary source HGNC:HGNC:19234 See related Ensembl:ENSG00000172728 MIM:616931; AllianceGenome:HGNC:19234 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUCTX Summary Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to act upstream of or within cerebral cortex radially oriented cell migration and neuronal stem cell population maintenance. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 2.0), placenta (RPKM 1.5) and 25 other tissues See more Orthologs mouse all
FUT11, Official Symbol FUT11provided by HGNC Official Full Name fucosyltransferase 11provided by HGNC Primary source HGNC:HGNC:19233 See related Ensembl:ENSG00000196968 MIM:616932; AllianceGenome:HGNC:19233 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUCTXI Summary Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 8.2), lung (RPKM 6.0) and 24 other tissues See more Orthologs mouse all
FUT2, Official Symbol FUT2provided by HGNC Official Full Name fucosyltransferase 2provided by HGNC Primary source HGNC:HGNC:4013 See related Ensembl:ENSG00000176920 MIM:182100; AllianceGenome:HGNC:4013 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SE; Se2; sej; SEC2; B12QTL1 Summary This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway. It is also involved in cell-cell interaction, cell surface expression, and cell proliferation. Mutations in this gene are a cause of the H-Bombay blood group where red blood cells lack the H antigen. [provided by RefSeq, May 2022] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Biased expression in duodenum (RPKM 17.4), stomach (RPKM 16.4) and 11 other tissues See more Orthologs mouse all
FUT3, Official Symbol FUT3provided by HGNC Official Full Name fucosyltransferase 3 (Lewis blood group)provided by HGNC Primary source HGNC:HGNC:4014 See related Ensembl:ENSG00000171124 MIM:111100; AllianceGenome:HGNC:4014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LE; Les; FT3B; CD174; FucT-III Summary The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020] Annotation information Annotation category: suggests misassembly Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process. Expression Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues See more Orthologs all
FUT4, Official Symbol FUT4provided by HGNC Official Full Name fucosyltransferase 4provided by HGNC Primary source HGNC:HGNC:4015 See related Ensembl:ENSG00000196371 MIM:104230; AllianceGenome:HGNC:4015 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV Summary The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009] Orthologs mouse all
FUT5, Official Symbol FUT5provided by HGNC Official Full Name fucosyltransferase 5provided by HGNC Primary source HGNC:HGNC:4016 See related Ensembl:ENSG00000130383 MIM:136835; AllianceGenome:HGNC:4016 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FUC-TV Summary Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in ceramide metabolic process and oligosaccharide metabolic process. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 6.2), esophagus (RPKM 5.3) and 8 other tissues See more Orthologs all