psui3905/ncbi_genes_summary huggingface dataset:
CCR1, Official Symbol CCR1provided by HGNC Official Full Name C-C motif chemokine receptor 1provided by HGNC Primary source HGNC:HGNC:1602 See related Ensembl:ENSG00000163823 MIM:601159; AllianceGenome:HGNC:1602 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1 Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 27.8), spleen (RPKM 15.6) and 17 other tissues See more Orthologs mouse all
CCR10, Official Symbol CCR10provided by HGNC Official Full Name C-C motif chemokine receptor 10provided by HGNC Primary source HGNC:HGNC:4474 See related Ensembl:ENSG00000184451 MIM:600240; AllianceGenome:HGNC:4474 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR2 Summary Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008] Expression Broad expression in fat (RPKM 3.5), colon (RPKM 2.5) and 15 other tissues See more Orthologs mouse all
CCR12P, Official Symbol CCR12Pprovided by HGNC Official Full Name C-C motif chemokine receptor 12, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39812 See related Ensembl:ENSG00000238241 AllianceGenome:HGNC:39812 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR183P1
CCR2, Official Symbol CCR2provided by HGNC Official Full Name C-C motif chemokine receptor 2provided by HGNC Primary source HGNC:HGNC:1603 See related Ensembl:ENSG00000121807 MIM:601267; AllianceGenome:HGNC:1603 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2 Summary The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017] Expression Biased expression in appendix (RPKM 15.2), lymph node (RPKM 5.1) and 12 other tissues See more Orthologs mouse all
CCR3, Official Symbol CCR3provided by HGNC Official Full Name C-C motif chemokine receptor 3provided by HGNC Primary source HGNC:HGNC:1604 See related Ensembl:ENSG00000183625 MIM:601268; AllianceGenome:HGNC:1604 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKR3; CD193; CKR 3; CMKBR3; C C CKR3; CC-CKR-3 Summary The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Low expression observed in reference dataset See more Orthologs mouse all
CCR4, Official Symbol CCR4provided by HGNC Official Full Name C-C motif chemokine receptor 4provided by HGNC Primary source HGNC:HGNC:1605 See related Ensembl:ENSG00000183813 MIM:604836; AllianceGenome:HGNC:1605 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099 Summary The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 6.5), urinary bladder (RPKM 6.3) and 12 other tissues See more Orthologs mouse all
CCR5, Official Symbol CCR5provided by HGNC Official Full Name C-C motif chemokine receptor 5provided by HGNC Primary source HGNC:HGNC:1606 See related Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5 Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Broad expression in appendix (RPKM 9.4), lymph node (RPKM 7.4) and 21 other tissues See more Orthologs all
CCR6, Official Symbol CCR6provided by HGNC Official Full Name C-C motif chemokine receptor 6provided by HGNC Primary source HGNC:HGNC:1607 See related Ensembl:ENSG00000112486 MIM:601835; AllianceGenome:HGNC:1607 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6 Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 8.0), appendix (RPKM 6.0) and 13 other tissues See more Orthologs mouse all
CCR7, Official Symbol CCR7provided by HGNC Official Full Name C-C motif chemokine receptor 7provided by HGNC Primary source HGNC:HGNC:1608 See related Ensembl:ENSG00000126353 MIM:600242; AllianceGenome:HGNC:1608 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7 Summary The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] Expression Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues See more Orthologs mouse all
CCR8, Official Symbol CCR8provided by HGNC Official Full Name C-C motif chemokine receptor 8provided by HGNC Primary source HGNC:HGNC:1609 See related Ensembl:ENSG00000179934 MIM:601834; AllianceGenome:HGNC:1609 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8 Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
CCR9, Official Symbol CCR9provided by HGNC Official Full Name C-C motif chemokine receptor 9provided by HGNC Primary source HGNC:HGNC:1610 See related Ensembl:ENSG00000173585 MIM:604738; AllianceGenome:HGNC:1610 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR28; CDw199; GPR-9-6; CC-CKR-9 Summary The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] Expression Biased expression in small intestine (RPKM 2.0), duodenum (RPKM 1.6) and 6 other tissues See more Orthologs mouse all
CCRL2, Official Symbol CCRL2provided by HGNC Official Full Name C-C motif chemokine receptor like 2provided by HGNC Primary source HGNC:HGNC:1612 See related Ensembl:ENSG00000121797 MIM:608379; AllianceGenome:HGNC:1612 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B Summary This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 6.4), lung (RPKM 6.3) and 20 other tissues See more Orthologs mouse all
CCS, Official Symbol CCSprovided by HGNC Official Full Name copper chaperone for superoxide dismutaseprovided by HGNC Primary source HGNC:HGNC:1613 See related Ensembl:ENSG00000173992 MIM:603864; AllianceGenome:HGNC:1613 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 18.8), spleen (RPKM 17.6) and 25 other tissues See more Orthologs mouse all
CCSAP, Official Symbol CCSAPprovided by HGNC Official Full Name centriole, cilia and spindle associated proteinprovided by HGNC Primary source HGNC:HGNC:29578 See related Ensembl:ENSG00000154429 MIM:616762; AllianceGenome:HGNC:29578 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSAP; C1orf96 Summary Enables microtubule binding activity. Involved in mitotic spindle microtubule depolymerization and regulation of mitotic spindle assembly. Located in axon; ciliary transition zone; and cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 20.5), placenta (RPKM 8.3) and 20 other tissues See more Orthologs mouse all
CCSER1, Official Symbol CCSER1provided by HGNC Official Full Name coiled-coil serine rich protein 1provided by HGNC Primary source HGNC:HGNC:29349 See related Ensembl:ENSG00000184305 MIM:618934; AllianceGenome:HGNC:29349 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM190A Expression Low expression observed in reference dataset See more Orthologs mouse all
CCSER2, Official Symbol CCSER2provided by HGNC Official Full Name coiled-coil serine rich protein 2provided by HGNC Primary source HGNC:HGNC:29197 See related Ensembl:ENSG00000107771 MIM:619944; AllianceGenome:HGNC:29197 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Gcap14; FAM190B; KIAA1128; bA486O22.1 Summary Predicted to enable microtubule binding activity. Predicted to act upstream of or within microtubule bundle formation. Predicted to be located in cytoplasm and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 13.5), testis (RPKM 13.1) and 25 other tissues See more Orthologs mouse all
CCT2, Official Symbol CCT2provided by HGNC Official Full Name chaperonin containing TCP1 subunit 2provided by HGNC Primary source HGNC:HGNC:1615 See related Ensembl:ENSG00000166226 MIM:605139; AllianceGenome:HGNC:1615 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCTB; 99D8.1; PRO1633; CCT-beta; HEL-S-100n; TCP-1-beta Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Expression Broad expression in testis (RPKM 107.5), bone marrow (RPKM 41.1) and 24 other tissues See more Orthologs mouse all
CCT3, Official Symbol CCT3provided by HGNC Official Full Name chaperonin containing TCP1 subunit 3provided by HGNC Primary source HGNC:HGNC:1616 See related Ensembl:ENSG00000163468 MIM:600114; AllianceGenome:HGNC:1616 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in testis (RPKM 72.7), adrenal (RPKM 56.4) and 25 other tissues See more Orthologs mouse all
CCT3P1, Official Symbol CCT3P1provided by HGNC Official Full Name chaperonin containing TCP1 subunit 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:35129 See related Ensembl:ENSG00000253951 AllianceGenome:HGNC:35129 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT3-1P
CCT4, Official Symbol CCT4provided by HGNC Official Full Name chaperonin containing TCP1 subunit 4provided by HGNC Primary source HGNC:HGNC:1617 See related Ensembl:ENSG00000115484 MIM:605142; AllianceGenome:HGNC:1617 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRB; Cctd; CCT-DELTA Summary The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in ovary (RPKM 58.5), testis (RPKM 51.7) and 25 other tissues See more Orthologs mouse all
CCT4P1, Official Symbol CCT4P1provided by HGNC Official Full Name chaperonin containing TCP1 subunit 4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:35151 See related AllianceGenome:HGNC:35151 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT4-2P
CCT4P2, Official Symbol CCT4P2provided by HGNC Official Full Name chaperonin containing TCP1 subunit 4 pseudogene 2provided by HGNC Primary source HGNC:HGNC:35141 See related Ensembl:ENSG00000225569 AllianceGenome:HGNC:35141 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT4-1P
CCT5, Official Symbol CCT5provided by HGNC Official Full Name chaperonin containing TCP1 subunit 5provided by HGNC Primary source HGNC:HGNC:1618 See related Ensembl:ENSG00000150753 MIM:610150; AllianceGenome:HGNC:1618 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCTE; HEL-S-69; PNAS-102; CCT-epsilon; TCP-1-epsilon Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015] Expression Ubiquitous expression in testis (RPKM 38.0), appendix (RPKM 31.8) and 25 other tissues See more Orthologs mouse all
CCT5P1, Official Symbol CCT5P1provided by HGNC Official Full Name chaperonin containing TCP1 subunit 5 pseudogene 1provided by HGNC Primary source HGNC:HGNC:35135 See related Ensembl:ENSG00000250444 AllianceGenome:HGNC:35135 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT5-3P
CCT5P2, Official Symbol CCT5P2provided by HGNC Official Full Name chaperonin containing TCP1 subunit 5 pseudogene 2provided by HGNC Primary source HGNC:HGNC:35139 See related Ensembl:ENSG00000230584 AllianceGenome:HGNC:35139 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT5-P1
CCT6A, Official Symbol CCT6Aprovided by HGNC Official Full Name chaperonin containing TCP1 subunit 6Aprovided by HGNC Primary source HGNC:HGNC:1620 See related Ensembl:ENSG00000146731 MIM:104613; AllianceGenome:HGNC:1620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010] Expression Ubiquitous expression in appendix (RPKM 44.1), lymph node (RPKM 38.8) and 25 other tissues See more Orthologs mouse all
CCT6B, Official Symbol CCT6Bprovided by HGNC Official Full Name chaperonin containing TCP1 subunit 6Bprovided by HGNC Primary source HGNC:HGNC:1621 See related Ensembl:ENSG00000132141 MIM:610730; AllianceGenome:HGNC:1621 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cctz2; CCTZ-2; TSA303; CCT-zeta-2; TCP-1-zeta-2 Summary This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] Expression Biased expression in testis (RPKM 57.4) and thyroid (RPKM 1.2) See more Orthologs mouse all
CCT6P2, Official Symbol CCT6P2provided by HGNC Official Full Name chaperonin containing TCP1 subunit 6 pseudogene 2provided by HGNC Primary source HGNC:HGNC:35150 See related Ensembl:ENSG00000250526 AllianceGenome:HGNC:35150 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT6-1P
CCT6P3, Official Symbol CCT6P3provided by HGNC Official Full Name chaperonin containing TCP1 subunit 6 pseudogene 3provided by HGNC Primary source HGNC:HGNC:35137 See related Ensembl:ENSG00000290860 AllianceGenome:HGNC:35137 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT6-3P Expression Ubiquitous expression in testis (RPKM 5.5), prostate (RPKM 4.9) and 25 other tissues See more
CCT7, Official Symbol CCT7provided by HGNC Official Full Name chaperonin containing TCP1 subunit 7provided by HGNC Primary source HGNC:HGNC:1622 See related Ensembl:ENSG00000135624 MIM:605140; AllianceGenome:HGNC:1622 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCTH; CCTETA; NIP7-1; TCP1ETA Summary This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in testis (RPKM 102.9), adrenal (RPKM 73.8) and 25 other tissues See more Orthologs mouse all
CCT7P1, Official Symbol CCT7P1provided by HGNC Official Full Name chaperonin containing TCP1 subunit 7 pseudogene 1provided by HGNC Primary source HGNC:HGNC:35149 See related Ensembl:ENSG00000217733 AllianceGenome:HGNC:35149 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT7-2P
CCT7P2, Official Symbol CCT7P2provided by HGNC Official Full Name chaperonin containing TCP1 subunit 7 pseudogene 2provided by HGNC Primary source HGNC:HGNC:35134 See related Ensembl:ENSG00000249958 AllianceGenome:HGNC:35134 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT7-1P
CCT8, Official Symbol CCT8provided by HGNC Official Full Name chaperonin containing TCP1 subunit 8provided by HGNC Primary source HGNC:HGNC:1623 See related Ensembl:ENSG00000156261 MIM:617786; AllianceGenome:HGNC:1623 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Cctq; PRED71; D21S246; C21orf112 Summary This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in adrenal (RPKM 57.9), lymph node (RPKM 57.3) and 25 other tissues See more Orthologs mouse all
CCT8L1P, Official Symbol CCT8L1Pprovided by HGNC Official Full Name chaperonin containing TCP1 subunit 8 like 1, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32153 See related Ensembl:ENSG00000020219 AllianceGenome:HGNC:32153 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT8L1 Summary Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of chaperonin-containing T-complex. [provided by Alliance of Genome Resources, Apr 2022]
CCT8L2, Official Symbol CCT8L2provided by HGNC Official Full Name chaperonin containing TCP1 subunit 8 like 2provided by HGNC Primary source HGNC:HGNC:15553 See related Ensembl:ENSG00000198445 AllianceGenome:HGNC:15553 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CESK1 Summary Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of chaperonin-containing T-complex. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
CCT8P1, Official Symbol CCT8P1provided by HGNC Official Full Name chaperonin containing TCP1 subunit 8 pseudogene 1provided by HGNC Primary source HGNC:HGNC:35144 See related Ensembl:ENSG00000226015 AllianceGenome:HGNC:35144 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCT8-1P
CCZ1, Official Symbol CCZ1provided by HGNC Official Full Name CCZ1 homolog, vacuolar protein trafficking and biogenesis associatedprovided by HGNC Primary source HGNC:HGNC:21691 See related Ensembl:ENSG00000122674 AllianceGenome:HGNC:21691 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCZ1A; CGI-43; C7orf28A; H_DJ1163J12.2 Summary Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 39.9), urinary bladder (RPKM 31.0) and 25 other tissues See more Orthologs mouse all
CCZ1B, Official Symbol CCZ1Bprovided by HGNC Official Full Name CCZ1 homolog B, vacuolar protein trafficking and biogenesis associatedprovided by HGNC Primary source HGNC:HGNC:21717 See related Ensembl:ENSG00000146574 AllianceGenome:HGNC:21717 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CCZ1; C7orf28A; C7orf28B; H_NH0577018.2 Summary Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 39.8), urinary bladder (RPKM 33.4) and 25 other tissues See more Orthologs all
CD101, Official Symbol CD101provided by HGNC Official Full Name CD101 moleculeprovided by HGNC Primary source HGNC:HGNC:5949 See related Ensembl:ENSG00000134256 MIM:604516; AllianceGenome:HGNC:5949 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as V7; IGSF2; EWI-101 Summary Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within positive regulation of myeloid leukocyte differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in small intestine (RPKM 2.3), lung (RPKM 2.1) and 18 other tissues See more Orthologs mouse all
CD109, Official Symbol CD109provided by HGNC Official Full Name CD109 moleculeprovided by HGNC Primary source HGNC:HGNC:21685 See related Ensembl:ENSG00000156535 MIM:608859; AllianceGenome:HGNC:21685 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p180; r150; CPAMD7 Summary This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] Expression Broad expression in skin (RPKM 9.8), endometrium (RPKM 7.6) and 21 other tissues See more Orthologs mouse all
CD14, Official Symbol CD14provided by HGNC Official Full Name CD14 moleculeprovided by HGNC Primary source HGNC:HGNC:1628 See related Ensembl:ENSG00000170458 MIM:158120; AllianceGenome:HGNC:1628 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment. Expression Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues See more Orthologs mouse all
CD151, Official Symbol CD151provided by HGNC Official Full Name CD151 molecule (Raph blood group)provided by HGNC Primary source HGNC:HGNC:1630 See related Ensembl:ENSG00000177697 MIM:602243; AllianceGenome:HGNC:1630 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EBS7; GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 188.8), lung (RPKM 142.9) and 25 other tissues See more Orthologs mouse all
CD160, Official Symbol CD160provided by HGNC Official Full Name CD160 moleculeprovided by HGNC Primary source HGNC:HGNC:17013 See related Ensembl:ENSG00000117281 MIM:604463; AllianceGenome:HGNC:17013 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NK1; BY55; NK28 Summary CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 5.2), duodenum (RPKM 1.7) and 12 other tissues See more Orthologs mouse all
CD163, Official Symbol CD163provided by HGNC Official Full Name CD163 moleculeprovided by HGNC Primary source HGNC:HGNC:1631 See related Ensembl:ENSG00000177575 MIM:605545; AllianceGenome:HGNC:1631 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as M130; MM130; SCARI1 Summary The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] Expression Broad expression in appendix (RPKM 85.9), spleen (RPKM 66.5) and 18 other tissues See more Orthologs all
CD163L1, Official Symbol CD163L1provided by HGNC Official Full Name CD163 molecule like 1provided by HGNC Primary source HGNC:HGNC:30375 See related Ensembl:ENSG00000177675 MIM:606079; AllianceGenome:HGNC:30375 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WC1; M160; STAR; CD163B; SCARI2 Summary This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] Expression Broad expression in spleen (RPKM 7.7), small intestine (RPKM 4.5) and 14 other tissues See more Orthologs all
CD164, Official Symbol CD164provided by HGNC Official Full Name CD164 moleculeprovided by HGNC Primary source HGNC:HGNC:1632 See related Ensembl:ENSG00000135535 MIM:603356; AllianceGenome:HGNC:1632 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNA66; MGC-24; MUC-24; MGC-24v; endolyn Summary This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016] Expression Ubiquitous expression in thyroid (RPKM 246.6), fat (RPKM 191.2) and 25 other tissues See more Orthologs mouse all
CD164L2, Official Symbol CD164L2provided by HGNC Official Full Name CD164 molecule like 2provided by HGNC Primary source HGNC:HGNC:32043 See related Ensembl:ENSG00000174950 AllianceGenome:HGNC:32043 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNQ6122; EAPG6122 Summary Predicted to be integral component of membrane. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 3.1), esophagus (RPKM 2.8) and 5 other tissues See more Orthologs mouse all