psui3905/ncbi_genes_summary huggingface dataset:
ADCY3, Official Symbol ADCY3provided by HGNC Official Full Name adenylate cyclase 3provided by HGNC Primary source HGNC:HGNC:234 See related Ensembl:ENSG00000138031 MIM:600291; AllianceGenome:HGNC:234 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC3; AC-III; BMIQ19 Summary This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in placenta (RPKM 27.7), ovary (RPKM 14.8) and 23 other tissues See more Orthologs mouse all
ADCY4, Official Symbol ADCY4provided by HGNC Official Full Name adenylate cyclase 4provided by HGNC Primary source HGNC:HGNC:235 See related Ensembl:ENSG00000129467 MIM:600292; AllianceGenome:HGNC:235 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC4 Summary This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] Expression Broad expression in placenta (RPKM 14.4), fat (RPKM 11.6) and 23 other tissues See more Orthologs mouse all
ADCY5, Official Symbol ADCY5provided by HGNC Official Full Name adenylate cyclase 5provided by HGNC Primary source HGNC:HGNC:236 See related Ensembl:ENSG00000173175 MIM:600293; AllianceGenome:HGNC:236 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC5; FDFM; DSKOD Summary This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Broad expression in heart (RPKM 22.9), brain (RPKM 7.3) and 17 other tissues See more Orthologs mouse all
ADCY6, Official Symbol ADCY6provided by HGNC Official Full Name adenylate cyclase 6provided by HGNC Primary source HGNC:HGNC:237 See related Ensembl:ENSG00000174233 MIM:600294; AllianceGenome:HGNC:237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC6; LCCS8 Summary This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015] Expression Ubiquitous expression in fat (RPKM 25.0), heart (RPKM 17.1) and 23 other tissues See more Orthologs mouse all
ADCY6-DT, Official Symbol ADCY6-DTprovided by HGNC Official Full Name ADCY6 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53332 See related Ensembl:ENSG00000257660 AllianceGenome:HGNC:53332 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ADCY7, Official Symbol ADCY7provided by HGNC Official Full Name adenylate cyclase 7provided by HGNC Primary source HGNC:HGNC:238 See related Ensembl:ENSG00000121281 MIM:600385; AllianceGenome:HGNC:238 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC7 Summary This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013] Expression Broad expression in spleen (RPKM 22.5), appendix (RPKM 19.0) and 24 other tissues See more Orthologs mouse all
ADCY8, Official Symbol ADCY8provided by HGNC Official Full Name adenylate cyclase 8provided by HGNC Primary source HGNC:HGNC:239 See related Ensembl:ENSG00000155897 MIM:103070; AllianceGenome:HGNC:239 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC8; ADCY3; HBAC1 Summary Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.1), lung (RPKM 0.8) and 2 other tissues See more Orthologs mouse all
ADCY9, Official Symbol ADCY9provided by HGNC Official Full Name adenylate cyclase 9provided by HGNC Primary source HGNC:HGNC:240 See related Ensembl:ENSG00000162104 MIM:603302; AllianceGenome:HGNC:240 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AC9; ACIX Summary Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 11.2), lung (RPKM 8.5) and 24 other tissues See more Orthologs mouse all
ADCYAP1, Official Symbol ADCYAP1provided by HGNC Official Full Name adenylate cyclase activating polypeptide 1provided by HGNC Primary source HGNC:HGNC:241 See related Ensembl:ENSG00000141433 MIM:102980; AllianceGenome:HGNC:241 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PACAP Summary This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013] Expression Biased expression in appendix (RPKM 6.6), brain (RPKM 5.7) and 11 other tissues See more Orthologs mouse all
ADCYAP1R1, Official Symbol ADCYAP1R1provided by HGNC Official Full Name ADCYAP receptor type Iprovided by HGNC Primary source HGNC:HGNC:242 See related Ensembl:ENSG00000078549 MIM:102981; AllianceGenome:HGNC:242 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAC1; PAC1R; PACAPR; PACAPRI Summary This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010] Expression Biased expression in brain (RPKM 39.8), adrenal (RPKM 5.5) and 1 other tissue See more Orthologs mouse all
ADD1, Official Symbol ADD1provided by HGNC Official Full Name adducin 1provided by HGNC Primary source HGNC:HGNC:243 See related Ensembl:ENSG00000087274 MIM:102680; AllianceGenome:HGNC:243 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADDA Summary Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in brain (RPKM 57.3), ovary (RPKM 51.1) and 25 other tissues See more Orthologs mouse all
ADD2, Official Symbol ADD2provided by HGNC Official Full Name adducin 2provided by HGNC Primary source HGNC:HGNC:244 See related Ensembl:ENSG00000075340 MIM:102681; AllianceGenome:HGNC:244 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADDB Summary Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010] Expression Biased expression in brain (RPKM 14.9), bone marrow (RPKM 7.7) and 4 other tissues See more Orthologs mouse all
ADD3, Official Symbol ADD3provided by HGNC Official Full Name adducin 3provided by HGNC Primary source HGNC:HGNC:245 See related Ensembl:ENSG00000148700 MIM:601568; AllianceGenome:HGNC:245 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADDL; CPSQ3 Summary Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 57.5), thyroid (RPKM 50.2) and 25 other tissues See more Orthologs mouse all
ADD3-AS1, Official Symbol ADD3-AS1provided by HGNC Official Full Name ADD3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:48682 See related Ensembl:ENSG00000203876 AllianceGenome:HGNC:48682 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 12.6), brain (RPKM 2.0) and 12 other tissues See more
ADGB, Official Symbol ADGBprovided by HGNC Official Full Name androglobinprovided by HGNC Primary source HGNC:HGNC:21212 See related Ensembl:ENSG00000118492 MIM:614630; AllianceGenome:HGNC:21212 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAPN16; C6orf103 Summary Predicted to enable calcium-dependent cysteine-type endopeptidase activity; heme binding activity; and oxygen binding activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 2.9) and lung (RPKM 0.4) See more Orthologs mouse all
ADGRA1, Official Symbol ADGRA1provided by HGNC Official Full Name adhesion G protein-coupled receptor A1provided by HGNC Primary source HGNC:HGNC:13838 See related Ensembl:ENSG00000197177 MIM:612302; AllianceGenome:HGNC:13838 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR123 Summary This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014] Expression Biased expression in brain (RPKM 3.7), adrenal (RPKM 1.0) and 1 other tissue See more Orthologs mouse all
ADGRA1-AS1, Official Symbol ADGRA1-AS1provided by HGNC Official Full Name ADGRA1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49543 See related AllianceGenome:HGNC:49543 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR123-AS1 Expression Biased expression in brain (RPKM 1.5), adrenal (RPKM 0.4) and 1 other tissue See more
ADGRA2, Official Symbol ADGRA2provided by HGNC Official Full Name adhesion G protein-coupled receptor A2provided by HGNC Primary source HGNC:HGNC:17849 See related Ensembl:ENSG00000020181 MIM:606823; AllianceGenome:HGNC:17849 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEM5; GPR124 Summary Predicted to enable G protein-coupled receptor activity. Involved in positive regulation of canonical Wnt signaling pathway. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in prostate (RPKM 39.9), fat (RPKM 36.6) and 23 other tissues See more Orthologs mouse all
ADGRA3, Official Symbol ADGRA3provided by HGNC Official Full Name adhesion G protein-coupled receptor A3provided by HGNC Primary source HGNC:HGNC:13839 See related Ensembl:ENSG00000152990 MIM:612303; AllianceGenome:HGNC:13839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR21; TEM5L; GPR125 Summary This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in thyroid (RPKM 9.5), liver (RPKM 6.2) and 24 other tissues See more Orthologs mouse all
ADGRB1, Official Symbol ADGRB1provided by HGNC Official Full Name adhesion G protein-coupled receptor B1provided by HGNC Primary source HGNC:HGNC:943 See related Ensembl:ENSG00000181790 MIM:602682; AllianceGenome:HGNC:943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAI1; GDAIF Summary Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 8.6), spleen (RPKM 1.3) and 4 other tissues See more Orthologs mouse all
ADGRB2, Official Symbol ADGRB2provided by HGNC Official Full Name adhesion G protein-coupled receptor B2provided by HGNC Primary source HGNC:HGNC:944 See related Ensembl:ENSG00000121753 MIM:602683; AllianceGenome:HGNC:944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAI2 Summary This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] Expression Biased expression in brain (RPKM 26.9), adrenal (RPKM 2.1) and 5 other tissues See more Orthologs mouse all
ADGRB3, Official Symbol ADGRB3provided by HGNC Official Full Name adhesion G protein-coupled receptor B3provided by HGNC Primary source HGNC:HGNC:945 See related Ensembl:ENSG00000135298 MIM:602684; AllianceGenome:HGNC:945 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAI3 Summary This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 7.6), adrenal (RPKM 0.8) and 3 other tissues See more Orthologs mouse all
ADGRD1, Official Symbol ADGRD1provided by HGNC Official Full Name adhesion G protein-coupled receptor D1provided by HGNC Primary source HGNC:HGNC:19893 See related Ensembl:ENSG00000111452 MIM:613639; AllianceGenome:HGNC:19893 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR25; GPR133 Summary The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010] Expression Broad expression in placenta (RPKM 7.4), lung (RPKM 6.8) and 20 other tissues See more Orthologs mouse all
ADGRD1-AS1, Official Symbol ADGRD1-AS1provided by HGNC Official Full Name ADGRD1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53314 See related AllianceGenome:HGNC:53314 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LACAT8 Expression Broad expression in lung (RPKM 4.2), placenta (RPKM 2.9) and 19 other tissues See more
ADGRD2, Official Symbol ADGRD2provided by HGNC Official Full Name adhesion G protein-coupled receptor D2provided by HGNC Primary source HGNC:HGNC:18651 See related Ensembl:ENSG00000180264 AllianceGenome:HGNC:18651 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR24; GPR144 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
ADGRE1, Official Symbol ADGRE1provided by HGNC Official Full Name adhesion G protein-coupled receptor E1provided by HGNC Primary source HGNC:HGNC:3336 See related Ensembl:ENSG00000174837 MIM:600493; AllianceGenome:HGNC:3336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EMR1; TM7LN3 Summary This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Expression Biased expression in spleen (RPKM 6.8), appendix (RPKM 4.1) and 12 other tissues See more Orthologs mouse all
ADGRE2, Official Symbol ADGRE2provided by HGNC Official Full Name adhesion G protein-coupled receptor E2provided by HGNC Primary source HGNC:HGNC:3337 See related Ensembl:ENSG00000127507 MIM:606100; AllianceGenome:HGNC:3337 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VBU; CD97; EMR2; CD312 Summary This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] Expression Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues See more Orthologs all
ADGRE3, Official Symbol ADGRE3provided by HGNC Official Full Name adhesion G protein-coupled receptor E3provided by HGNC Primary source HGNC:HGNC:23647 See related Ensembl:ENSG00000131355 MIM:606101; AllianceGenome:HGNC:23647 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EMR3 Summary This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014] Expression Biased expression in appendix (RPKM 3.7), spleen (RPKM 2.5) and 12 other tissues See more Orthologs mouse all
ADGRE5, Official Symbol ADGRE5provided by HGNC Official Full Name adhesion G protein-coupled receptor E5provided by HGNC Primary source HGNC:HGNC:1711 See related Ensembl:ENSG00000123146 MIM:601211; AllianceGenome:HGNC:1711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD97; TM7LN1 Summary This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] Expression Broad expression in bone marrow (RPKM 63.9), spleen (RPKM 54.1) and 23 other tissues See more Orthologs mouse all
ADGRF1, Official Symbol ADGRF1provided by HGNC Official Full Name adhesion G protein-coupled receptor F1provided by HGNC Primary source HGNC:HGNC:18990 See related Ensembl:ENSG00000153292 MIM:617430; AllianceGenome:HGNC:18990 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR19; GPR110; KPG_012; hGPCR36 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in urinary bladder (RPKM 9.0), kidney (RPKM 6.7) and 5 other tissues See more Orthologs mouse all
ADGRF2, Official Symbol ADGRF2provided by HGNC Official Full Name adhesion G protein-coupled receptor F2provided by HGNC Primary source HGNC:HGNC:18991 See related AllianceGenome:HGNC:18991 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR20; GPR111; hGPCR35 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 1.2), esophagus (RPKM 0.3) and 1 other tissue See more Orthologs all
ADGRF3, Official Symbol ADGRF3provided by HGNC Official Full Name adhesion G protein-coupled receptor F3provided by HGNC Primary source HGNC:HGNC:18989 See related Ensembl:ENSG00000173567 AllianceGenome:HGNC:18989 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR23; GPR113 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
ADGRF4, Official Symbol ADGRF4provided by HGNC Official Full Name adhesion G protein-coupled receptor F4provided by HGNC Primary source HGNC:HGNC:19011 See related Ensembl:ENSG00000153294 MIM:614268; AllianceGenome:HGNC:19011 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR18; GPR115 Summary Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016] Expression Biased expression in skin (RPKM 17.6), esophagus (RPKM 6.4) and 3 other tissues See more Orthologs mouse all
ADGRF5, Official Symbol ADGRF5provided by HGNC Official Full Name adhesion G protein-coupled receptor F5provided by HGNC Primary source HGNC:HGNC:19030 See related Ensembl:ENSG00000069122 AllianceGenome:HGNC:19030 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR116; KPG_001 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to act upstream of or within several processes, including glomerular filtration; pharyngeal arch artery morphogenesis; and surfactant homeostasis. Located in cell surface and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lung (RPKM 71.0), fat (RPKM 49.8) and 16 other tissues See more Orthologs mouse all
ADGRF5-AS1, Official Symbol ADGRF5-AS1provided by HGNC Official Full Name ADGRF5 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40864 See related AllianceGenome:HGNC:40864 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ADGRF5P1, Official Symbol ADGRF5P1provided by HGNC Official Full Name adhesion G protein-coupled receptor F5 pseudogene 1provided by HGNC Primary source HGNC:HGNC:32922 See related Ensembl:ENSG00000227582 AllianceGenome:HGNC:32922 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR116P1
ADGRF5P2, Official Symbol ADGRF5P2provided by HGNC Official Full Name adhesion G protein-coupled receptor F5 pseudogene 2provided by HGNC Primary source HGNC:HGNC:32921 See related AllianceGenome:HGNC:32921 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR116P2
ADGRG1, Official Symbol ADGRG1provided by HGNC Official Full Name adhesion G protein-coupled receptor G1provided by HGNC Primary source HGNC:HGNC:4512 See related Ensembl:ENSG00000205336 MIM:604110; AllianceGenome:HGNC:4512 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BFPP; BPPR; GPR56; TM7LN4; TM7XN1 Summary This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Broad expression in thyroid (RPKM 64.7), brain (RPKM 53.2) and 20 other tissues See more Orthologs mouse all
ADGRG2, Official Symbol ADGRG2provided by HGNC Official Full Name adhesion G protein-coupled receptor G2provided by HGNC Primary source HGNC:HGNC:4516 See related Ensembl:ENSG00000173698 MIM:300572; AllianceGenome:HGNC:4516 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HE6; EDDM6; GPR64; CBAVDX; TM7LN2 Summary This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Biased expression in stomach (RPKM 3.6), lymph node (RPKM 2.3) and 13 other tissues See more Orthologs mouse all
ADGRG3, Official Symbol ADGRG3provided by HGNC Official Full Name adhesion G protein-coupled receptor G3provided by HGNC Primary source HGNC:HGNC:13728 See related Ensembl:ENSG00000182885 MIM:618441; AllianceGenome:HGNC:13728 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PB99; GPR97; PGR26 Summary Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue See more Orthologs mouse all
ADGRG4, Official Symbol ADGRG4provided by HGNC Official Full Name adhesion G protein-coupled receptor G4provided by HGNC Primary source HGNC:HGNC:18992 See related Ensembl:ENSG00000156920 MIM:301085; AllianceGenome:HGNC:18992 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR17; GPR112; RP1-299I16 Summary This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010] Expression Biased expression in duodenum (RPKM 1.3), small intestine (RPKM 0.8) and 2 other tissues See more Orthologs mouse all
ADGRG5, Official Symbol ADGRG5provided by HGNC Official Full Name adhesion G protein-coupled receptor G5provided by HGNC Primary source HGNC:HGNC:19010 See related Ensembl:ENSG00000159618 MIM:616965; AllianceGenome:HGNC:19010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PGR27; GPR114 Summary This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Biased expression in lymph node (RPKM 4.6), spleen (RPKM 3.3) and 13 other tissues See more Orthologs mouse all
ADGRG6, Official Symbol ADGRG6provided by HGNC Official Full Name adhesion G protein-coupled receptor G6provided by HGNC Primary source HGNC:HGNC:13841 See related Ensembl:ENSG00000112414 MIM:612243; AllianceGenome:HGNC:13841 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APG1; DREG; VIGR; LCCS9; PR126; GPR126; PS1TP2 Summary This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009] Expression Broad expression in placenta (RPKM 17.7), liver (RPKM 15.5) and 18 other tissues See more Orthologs mouse all
ADGRG7, Official Symbol ADGRG7provided by HGNC Official Full Name adhesion G protein-coupled receptor G7provided by HGNC Primary source HGNC:HGNC:19241 See related Ensembl:ENSG00000144820 MIM:612307; AllianceGenome:HGNC:19241 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR128 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 18.5), small intestine (RPKM 17.4) and 2 other tissues See more Orthologs mouse all
ADGRL1, Official Symbol ADGRL1provided by HGNC Official Full Name adhesion G protein-coupled receptor L1provided by HGNC Primary source HGNC:HGNC:20973 See related Ensembl:ENSG00000072071 MIM:616416; AllianceGenome:HGNC:20973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL1; LEC2; CIRL1; LPHN1; DEDBANP Summary This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] Expression Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues See more Orthologs mouse all
ADGRL1-AS1, Official Symbol ADGRL1-AS1provided by HGNC Official Full Name ADGRL1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55309 See related Ensembl:ENSG00000267169 AllianceGenome:HGNC:55309 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 2.9), spleen (RPKM 1.6) and 24 other tissues See more
ADGRL2, Official Symbol ADGRL2provided by HGNC Official Full Name adhesion G protein-coupled receptor L2provided by HGNC Primary source HGNC:HGNC:18582 See related Ensembl:ENSG00000117114 MIM:607018; AllianceGenome:HGNC:18582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL2; LEC1; CIRL2; LPHH1; LPHN2 Summary This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in thyroid (RPKM 16.1), lung (RPKM 14.8) and 23 other tissues See more Orthologs mouse all