psui3905/ncbi_genes_summary huggingface dataset:
CR2, Official Symbol CR2provided by HGNC Official Full Name complement C3d receptor 2provided by HGNC Primary source HGNC:HGNC:2336 See related Ensembl:ENSG00000117322 MIM:120650; AllianceGenome:HGNC:2336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CR; C3DR; CD21; CVID7; SLEB9 Summary This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] Expression Biased expression in lymph node (RPKM 99.4), spleen (RPKM 44.6) and 1 other tissue See more Orthologs mouse all
CRABP1, Official Symbol CRABP1provided by HGNC Official Full Name cellular retinoic acid binding protein 1provided by HGNC Primary source HGNC:HGNC:2338 See related Ensembl:ENSG00000166426 MIM:180230; AllianceGenome:HGNC:2338 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RBP5; CRABP; CRABPI; CRABP-I Summary This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008] Expression Biased expression in thyroid (RPKM 65.7), spleen (RPKM 23.2) and 3 other tissues See more Orthologs mouse all
CRABP2, Official Symbol CRABP2provided by HGNC Official Full Name cellular retinoic acid binding protein 2provided by HGNC Primary source HGNC:HGNC:2339 See related Ensembl:ENSG00000143320 MIM:180231; AllianceGenome:HGNC:2339 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RBP6; CRABP-II Summary This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010] Expression Biased expression in esophagus (RPKM 46.7), skin (RPKM 7.1) and 2 other tissues See more Orthologs mouse all
CRACD, Official Symbol CRACDprovided by HGNC Official Full Name capping protein inhibiting regulator of actin dynamicsprovided by HGNC Primary source HGNC:HGNC:29219 See related Ensembl:ENSG00000109265 MIM:618327; AllianceGenome:HGNC:29219 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRAD; KIAA1211 Summary Involved in negative regulation of barbed-end actin filament capping. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 12.2), small intestine (RPKM 8.0) and 13 other tissues See more Orthologs mouse all
CRACDL, Official Symbol CRACDLprovided by HGNC Official Full Name CRACD likeprovided by HGNC Primary source HGNC:HGNC:33454 See related Ensembl:ENSG00000196872 AllianceGenome:HGNC:33454 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf55; KIAA1211L Expression Broad expression in brain (RPKM 4.1), esophagus (RPKM 1.2) and 18 other tissues See more Orthologs mouse all
CRACR2A, Official Symbol CRACR2Aprovided by HGNC Official Full Name calcium release activated channel regulator 2Aprovided by HGNC Primary source HGNC:HGNC:28657 See related Ensembl:ENSG00000130038 MIM:614178; AllianceGenome:HGNC:28657 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAB46; EFCAB4B Summary Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated calcium channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in salivary gland (RPKM 9.7), colon (RPKM 7.2) and 16 other tissues See more Orthologs mouse all
CRACR2B, Official Symbol CRACR2Bprovided by HGNC Official Full Name calcium release activated channel regulator 2Bprovided by HGNC Primary source HGNC:HGNC:28703 See related Ensembl:ENSG00000177685 MIM:614177; AllianceGenome:HGNC:28703 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EFCAB4A Summary Predicted to enable calcium ion binding activity. Involved in store-operated calcium entry. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in salivary gland (RPKM 19.1), stomach (RPKM 14.0) and 12 other tissues See more Orthologs mouse all
CRADD, Official Symbol CRADDprovided by HGNC Official Full Name CASP2 and RIPK1 domain containing adaptor with death domainprovided by HGNC Primary source HGNC:HGNC:2340 See related Ensembl:ENSG00000169372 MIM:603454; AllianceGenome:HGNC:2340 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT34; RAIDD Summary This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in heart (RPKM 3.8), liver (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
CRAMP1, Official Symbol CRAMP1provided by HGNC Official Full Name cramped chromatin regulator homolog 1provided by HGNC Primary source HGNC:HGNC:14122 See related Ensembl:ENSG00000007545 AllianceGenome:HGNC:14122 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HN1L; TCE4; CRAMP1L Summary Predicted to enable chromatin binding activity. Predicted to be involved in pattern specification process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 13.3), skin (RPKM 5.0) and 24 other tissues See more Orthologs mouse all
CRAT, Official Symbol CRATprovided by HGNC Official Full Name carnitine O-acetyltransferaseprovided by HGNC Primary source HGNC:HGNC:2342 See related Ensembl:ENSG00000095321 MIM:600184; AllianceGenome:HGNC:2342 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAT; CAT1; NBIA8 Summary This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016] Expression Broad expression in testis (RPKM 76.6), duodenum (RPKM 25.0) and 23 other tissues See more Orthologs mouse all
CRAT37, Gene symbol CRAT37 Gene description cervical cancer-associated transcript 37 See related Ensembl:ENSG00000258551 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
CRB1, Official Symbol CRB1provided by HGNC Official Full Name crumbs cell polarity complex component 1provided by HGNC Primary source HGNC:HGNC:2343 See related Ensembl:ENSG00000134376 MIM:604210; AllianceGenome:HGNC:2343 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LCA8; RP12; CRB1-A; CRB1-B; CRB1-C Summary This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012] Expression Biased expression in brain (RPKM 4.0) and testis (RPKM 1.3) See more Orthologs mouse all
CRB2, Official Symbol CRB2provided by HGNC Official Full Name crumbs cell polarity complex component 2provided by HGNC Primary source HGNC:HGNC:18688 See related Ensembl:ENSG00000148204 MIM:609720; AllianceGenome:HGNC:18688 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FSGS9; VMCKD Summary This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. [provided by RefSeq, Aug 2016] Expression Broad expression in brain (RPKM 3.7), kidney (RPKM 3.4) and 23 other tissues See more Orthologs mouse all
CRB3, Official Symbol CRB3provided by HGNC Official Full Name crumbs cell polarity complex component 3provided by HGNC Primary source HGNC:HGNC:20237 See related Ensembl:ENSG00000130545 MIM:609737; AllianceGenome:HGNC:20237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] Expression Broad expression in colon (RPKM 9.7), duodenum (RPKM 9.6) and 16 other tissues See more Orthologs mouse all
CRB3P1, Official Symbol CRB3P1provided by HGNC Official Full Name crumbs cell polarity complex component 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49684 See related Ensembl:ENSG00000232563 AllianceGenome:HGNC:49684 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CRBN, Official Symbol CRBNprovided by HGNC Official Full Name cereblonprovided by HGNC Primary source HGNC:HGNC:30185 See related Ensembl:ENSG00000113851 MIM:609262; AllianceGenome:HGNC:30185 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT2; MRT2A Summary This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in testis (RPKM 17.6), brain (RPKM 16.5) and 25 other tissues See more Orthologs mouse all
CRCP, Official Symbol CRCPprovided by HGNC Official Full Name CGRP receptor componentprovided by HGNC Primary source HGNC:HGNC:17888 See related Ensembl:ENSG00000241258 MIM:606121; AllianceGenome:HGNC:17888 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C17; RCP; RCP9; RPC9; POLR3I; POLR3J; CGRPRCP; CGRP-RCP Summary This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 11.5), thyroid (RPKM 11.3) and 25 other tissues See more Orthologs mouse all
CRCT1, Official Symbol CRCT1provided by HGNC Official Full Name cysteine rich C-terminal 1provided by HGNC Primary source HGNC:HGNC:29875 See related Ensembl:ENSG00000169509 MIM:617426; AllianceGenome:HGNC:29875 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NICE1; NICE-1; C1orf42 Expression Biased expression in skin (RPKM 17.3) and esophagus (RPKM 17.1) See more Orthologs mouse all
CREB1, Official Symbol CREB1provided by HGNC Official Full Name cAMP responsive element binding protein 1provided by HGNC Primary source HGNC:HGNC:2345 See related Ensembl:ENSG00000118260 MIM:123810; AllianceGenome:HGNC:2345 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CREB; CREB-1 Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in lymph node (RPKM 5.0), thyroid (RPKM 4.7) and 25 other tissues See more Orthologs mouse all
CREB3, Official Symbol CREB3provided by HGNC Official Full Name cAMP responsive element binding protein 3provided by HGNC Primary source HGNC:HGNC:2347 See related Ensembl:ENSG00000107175 MIM:606443; AllianceGenome:HGNC:2347 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LZIP; LUMAN; sLZIP Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009] Expression Ubiquitous expression in prostate (RPKM 27.8), testis (RPKM 25.9) and 25 other tissues See more Orthologs mouse all
CREB3L1, Official Symbol CREB3L1provided by HGNC Official Full Name cAMP responsive element binding protein 3 like 1provided by HGNC Primary source HGNC:HGNC:18856 See related Ensembl:ENSG00000157613 MIM:616215; AllianceGenome:HGNC:18856 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OI16; OASIS; DEL16p11.2; C16DELp11.2 Summary The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013] Expression Broad expression in stomach (RPKM 29.2), colon (RPKM 23.7) and 16 other tissues See more Orthologs mouse all
CREB3L2, Official Symbol CREB3L2provided by HGNC Official Full Name cAMP responsive element binding protein 3 like 2provided by HGNC Primary source HGNC:HGNC:23720 See related Ensembl:ENSG00000182158 MIM:608834; AllianceGenome:HGNC:23720 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BBF2H7 Summary This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in thyroid (RPKM 36.0), placenta (RPKM 17.4) and 24 other tissues See more Orthologs mouse all
CREB3L2-AS1, Official Symbol CREB3L2-AS1provided by HGNC Official Full Name CREB3L2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41030 See related Ensembl:ENSG00000237243 AllianceGenome:HGNC:41030 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more Orthologs all
CREB3L3, Official Symbol CREB3L3provided by HGNC Official Full Name cAMP responsive element binding protein 3 like 3provided by HGNC Primary source HGNC:HGNC:18855 See related Ensembl:ENSG00000060566 MIM:611998; AllianceGenome:HGNC:18855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CREBH; HYTG2; CREB-H; HYST1481 Summary This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] Expression Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue See more Orthologs mouse all
CREB3L4, Official Symbol CREB3L4provided by HGNC Official Full Name cAMP responsive element binding protein 3 like 4provided by HGNC Primary source HGNC:HGNC:18854 See related Ensembl:ENSG00000143578 MIM:607138; AllianceGenome:HGNC:18854 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP Summary This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Broad expression in prostate (RPKM 52.3), stomach (RPKM 10.0) and 20 other tissues See more Orthologs mouse all
CREB5, Official Symbol CREB5provided by HGNC Official Full Name cAMP responsive element binding protein 5provided by HGNC Primary source HGNC:HGNC:16844 See related Ensembl:ENSG00000146592 MIM:618262; AllianceGenome:HGNC:16844 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CREB-5; CREBPA; CRE-BPA Summary The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues See more Orthologs mouse all
CREBBP, Official Symbol CREBBPprovided by HGNC Official Full Name CREB binding proteinprovided by HGNC Primary source HGNC:HGNC:2348 See related Ensembl:ENSG00000005339 MIM:600140; AllianceGenome:HGNC:2348 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBP; RSTS; KAT3A; MKHK1; RSTS1 Summary This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] Expression Ubiquitous expression in testis (RPKM 12.8), bone marrow (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
CREBL2, Official Symbol CREBL2provided by HGNC Official Full Name cAMP responsive element binding protein like 2provided by HGNC Primary source HGNC:HGNC:2350 See related Ensembl:ENSG00000111269 MIM:603476; AllianceGenome:HGNC:2350 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 84.6), thyroid (RPKM 31.5) and 23 other tissues See more Orthologs mouse all
CREBRF, Official Symbol CREBRFprovided by HGNC Official Full Name CREB3 regulatory factorprovided by HGNC Primary source HGNC:HGNC:24050 See related Ensembl:ENSG00000164463 MIM:617109; AllianceGenome:HGNC:24050 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRF; C5orf41 Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of transport; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 12.2), bone marrow (RPKM 8.3) and 25 other tissues See more Orthologs mouse all
CREBZF, Official Symbol CREBZFprovided by HGNC Official Full Name CREB/ATF bZIP transcription factorprovided by HGNC Primary source HGNC:HGNC:24905 See related Ensembl:ENSG00000137504 MIM:606444; AllianceGenome:HGNC:24905 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZF; SMILE Summary Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; and response to virus. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 18.3), spleen (RPKM 18.1) and 25 other tissues See more Orthologs mouse all
CREG1, Official Symbol CREG1provided by HGNC Official Full Name cellular repressor of E1A stimulated genes 1provided by HGNC Primary source HGNC:HGNC:2351 See related Ensembl:ENSG00000143162 MIM:618055; AllianceGenome:HGNC:2351 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CREG Summary The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in gall bladder (RPKM 83.3), thyroid (RPKM 78.7) and 25 other tissues See more Orthologs mouse all
CREG2, Official Symbol CREG2provided by HGNC Official Full Name cellular repressor of E1A stimulated genes 2provided by HGNC Primary source HGNC:HGNC:14272 See related Ensembl:ENSG00000175874 MIM:618540; AllianceGenome:HGNC:14272 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward brain (RPKM 23.3) See more Orthologs mouse all
CRELD1, Official Symbol CRELD1provided by HGNC Official Full Name cysteine rich with EGF like domains 1provided by HGNC Primary source HGNC:HGNC:14630 See related Ensembl:ENSG00000163703 MIM:607170; AllianceGenome:HGNC:14630 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AVSD2; CIRRIN Summary This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] Expression Ubiquitous expression in thyroid (RPKM 17.8), heart (RPKM 15.1) and 25 other tissues See more Orthologs mouse all
CRELD2, Official Symbol CRELD2provided by HGNC Official Full Name cysteine rich with EGF like domains 2provided by HGNC Primary source HGNC:HGNC:28150 See related Ensembl:ENSG00000184164 MIM:607171; AllianceGenome:HGNC:28150 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 19.3), testis (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
CREM, Official Symbol CREMprovided by HGNC Official Full Name cAMP responsive element modulatorprovided by HGNC Primary source HGNC:HGNC:2352 See related Ensembl:ENSG00000095794 MIM:123812; AllianceGenome:HGNC:2352 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ICER; CREM-2; hCREM-2 Summary This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 19.2), adrenal (RPKM 15.7) and 21 other tissues See more Orthologs mouse all
CRH, Official Symbol CRHprovided by HGNC Official Full Name corticotropin releasing hormoneprovided by HGNC Primary source HGNC:HGNC:2355 See related Ensembl:ENSG00000147571 MIM:122560; AllianceGenome:HGNC:2355 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRF; CRH1 Summary This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015] Expression Biased expression in placenta (RPKM 2.8), fat (RPKM 0.8) and 2 other tissues See more Orthologs mouse all
CRHBP, Official Symbol CRHBPprovided by HGNC Official Full Name corticotropin releasing hormone binding proteinprovided by HGNC Primary source HGNC:HGNC:2356 See related Ensembl:ENSG00000145708 MIM:122559; AllianceGenome:HGNC:2356 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRFBP; CRF-BP Summary Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues See more Orthologs mouse all
CRHR1, Official Symbol CRHR1provided by HGNC Official Full Name corticotropin releasing hormone receptor 1provided by HGNC Primary source HGNC:HGNC:2357 See related Ensembl:ENSG00000120088 MIM:122561; AllianceGenome:HGNC:2357 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRF-R-1; CRH-R-1 Summary This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016] Expression Biased expression in brain (RPKM 2.0), endometrium (RPKM 0.5) and 3 other tissues See more Orthologs mouse all
CRHR2, Official Symbol CRHR2provided by HGNC Official Full Name corticotropin releasing hormone receptor 2provided by HGNC Primary source HGNC:HGNC:2358 See related Ensembl:ENSG00000106113 MIM:602034; AllianceGenome:HGNC:2358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRF2; CRFR2; CRF-RB; HM-CRF Summary The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
CRIM1, Official Symbol CRIM1provided by HGNC Official Full Name cysteine rich transmembrane BMP regulator 1provided by HGNC Primary source HGNC:HGNC:2359 See related Ensembl:ENSG00000150938 MIM:606189; AllianceGenome:HGNC:2359 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S52; CRIM-1 Summary This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010] Expression Broad expression in placenta (RPKM 93.7), fat (RPKM 55.7) and 23 other tissues See more Orthologs mouse all
CRIM1-DT, Official Symbol CRIM1-DTprovided by HGNC Official Full Name CRIM1 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:54057 See related AllianceGenome:HGNC:54057 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in fat (RPKM 5.5), brain (RPKM 5.1) and 23 other tissues See more
CRIP1, Official Symbol CRIP1provided by HGNC Official Full Name cysteine rich protein 1provided by HGNC Primary source HGNC:HGNC:2360 See related Ensembl:ENSG00000213145 MIM:123875; AllianceGenome:HGNC:2360 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRHP; CRIP; CRP1; CRP-1 Summary Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008] Expression Broad expression in small intestine (RPKM 154.6), lung (RPKM 120.1) and 20 other tissues See more Orthologs mouse all
CRIP1P1, Official Symbol CRIP1P1provided by HGNC Official Full Name cysteine rich protein 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44516 See related Ensembl:ENSG00000233252 AllianceGenome:HGNC:44516 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CRIP1P3, Official Symbol CRIP1P3provided by HGNC Official Full Name cysteine rich protein 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:44518 See related Ensembl:ENSG00000227109 AllianceGenome:HGNC:44518 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CRIP2, Official Symbol CRIP2provided by HGNC Official Full Name cysteine rich protein 2provided by HGNC Primary source HGNC:HGNC:2361 See related Ensembl:ENSG00000182809 MIM:601183; AllianceGenome:HGNC:2361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRIP; CRP2; ESP1 Summary This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Broad expression in heart (RPKM 55.7), lung (RPKM 26.3) and 23 other tissues See more Orthologs mouse all
CRIP3, Official Symbol CRIP3provided by HGNC Official Full Name cysteine rich protein 3provided by HGNC Primary source HGNC:HGNC:17751 See related Ensembl:ENSG00000146215 AllianceGenome:HGNC:17751 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TLP; CRP-3; TLP-A; h6LIMo Summary Predicted to enable metal ion binding activity. Predicted to act upstream of or within T cell proliferation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 2.8), heart (RPKM 2.6) and 13 other tissues See more Orthologs mouse all
CRIPT, Official Symbol CRIPTprovided by HGNC Official Full Name CXXC repeat containing interactor of PDZ3 domainprovided by HGNC Primary source HGNC:HGNC:14312 See related Ensembl:ENSG00000119878 MIM:604594; AllianceGenome:HGNC:14312 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SSMDF; HSPC139 Summary This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014] Expression Ubiquitous expression in brain (RPKM 3.3), adrenal (RPKM 2.2) and 25 other tissues See more Orthologs mouse all
CRISP1, Official Symbol CRISP1provided by HGNC Official Full Name cysteine rich secretory protein 1provided by HGNC Primary source HGNC:HGNC:304 See related Ensembl:ENSG00000124812 MIM:601193; AllianceGenome:HGNC:304 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARP; AEGL1; HUMARP; CRISP-1; HEL-S-57; HSCRISP1D; HSCRISP1G Summary Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
CRISP2, Official Symbol CRISP2provided by HGNC Official Full Name cysteine rich secretory protein 2provided by HGNC Primary source HGNC:HGNC:12024 See related Ensembl:ENSG00000124490 MIM:187430; AllianceGenome:HGNC:12024 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT36; TPX1; TSP1; GAPDL5; CRISP-2 Summary Predicted to be involved in cell-cell adhesion. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 156.0) See more Orthologs mouse all