psui3905/ncbi_genes_summary huggingface dataset:
TMSB10, Official Symbol TMSB10provided by HGNC Official Full Name thymosin beta 10provided by HGNC Primary source HGNC:HGNC:11879 See related Ensembl:ENSG00000034510 MIM:188399; AllianceGenome:HGNC:11879 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TB10; MIG12 Summary Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in appendix (RPKM 826.8), colon (RPKM 808.9) and 25 other tissues See more Orthologs mouse all
TMSB15A, Official Symbol TMSB15Aprovided by HGNC Official Full Name thymosin beta 15Aprovided by HGNC Primary source HGNC:HGNC:30744 See related Ensembl:ENSG00000158164 MIM:300939; AllianceGenome:HGNC:30744 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Tb15; TbNB; TMSL8; TMSNB; TMSB15; TMSB15B Summary Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in prostate (RPKM 5.7), endometrium (RPKM 2.4) and 14 other tissues See more Orthologs mouse all
TMSB4X, Official Symbol TMSB4Xprovided by HGNC Official Full Name thymosin beta 4 X-linkedprovided by HGNC Primary source HGNC:HGNC:11881 See related Ensembl:ENSG00000205542 MIM:300159; AllianceGenome:HGNC:11881 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FX; TB4X; PTMB4; TMSB4 Summary This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 3301.5), lymph node (RPKM 3201.4) and 24 other tissues See more Orthologs mouse all
TMSB4XP3, Official Symbol TMSB4XP3provided by HGNC Official Full Name TMSB4X pseudogene 3provided by HGNC Primary source HGNC:HGNC:38587 See related Ensembl:ENSG00000223437 AllianceGenome:HGNC:38587 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TMSB4XP4, Official Symbol TMSB4XP4provided by HGNC Official Full Name TMSB4X pseudogene 4provided by HGNC Primary source HGNC:HGNC:11886 See related Ensembl:ENSG00000223551 AllianceGenome:HGNC:11886 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMSL4
TMSB4Y, Official Symbol TMSB4Yprovided by HGNC Official Full Name thymosin beta 4 Y-linkedprovided by HGNC Primary source HGNC:HGNC:11882 See related Ensembl:ENSG00000154620 MIM:400017; AllianceGenome:HGNC:11882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TB4Y Summary This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 2.3), prostate (RPKM 2.2) and 19 other tissues See more Orthologs all
TMTC1, Official Symbol TMTC1provided by HGNC Official Full Name transmembrane O-mannosyltransferase targeting cadherins 1provided by HGNC Primary source HGNC:HGNC:24099 See related Ensembl:ENSG00000133687 MIM:615855; AllianceGenome:HGNC:24099 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OLF; ARG99; TMTC1A Summary Enables mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 11.8), spleen (RPKM 11.6) and 20 other tissues See more Orthologs mouse all
TMTC2, Official Symbol TMTC2provided by HGNC Official Full Name transmembrane O-mannosyltransferase targeting cadherins 2provided by HGNC Primary source HGNC:HGNC:25440 See related Ensembl:ENSG00000179104 MIM:615856; AllianceGenome:HGNC:25440 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IBDBP1 Summary The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in brain (RPKM 7.5), gall bladder (RPKM 7.0) and 24 other tissues See more Orthologs mouse all
TMTC3, Official Symbol TMTC3provided by HGNC Official Full Name transmembrane O-mannosyltransferase targeting cadherins 3provided by HGNC Primary source HGNC:HGNC:26899 See related Ensembl:ENSG00000139324 MIM:617218; AllianceGenome:HGNC:26899 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIS8; SMILE Summary This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010] Expression Ubiquitous expression in skin (RPKM 6.6), esophagus (RPKM 5.7) and 25 other tissues See more Orthologs mouse all
TMTC4, Official Symbol TMTC4provided by HGNC Official Full Name transmembrane O-mannosyltransferase targeting cadherins 4provided by HGNC Primary source HGNC:HGNC:25904 See related Ensembl:ENSG00000125247 MIM:618203; AllianceGenome:HGNC:25904 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a transmembrane protein that belongs to family of proteins containing an N-terminal transmembrane domain and a C-terminal tetratricopeptide repeat (TPR) domain. TPR domains mediate protein-protein interactions in various cellular processes, such as synaptic vesicle fusion, protein folding, and protein translocation. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in brain (RPKM 8.0), testis (RPKM 5.8) and 25 other tissues See more Orthologs mouse all
TMUB1, Official Symbol TMUB1provided by HGNC Official Full Name transmembrane and ubiquitin like domain containing 1provided by HGNC Primary source HGNC:HGNC:21709 See related Ensembl:ENSG00000164897 MIM:614792; AllianceGenome:HGNC:21709 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DULP; HOPS; SB144; C7orf21 Summary Involved in ubiquitin-dependent ERAD pathway. Predicted to be located in several cellular components, including nucleolus; postsynaptic membrane; and recycling endosome. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 10.6), kidney (RPKM 10.4) and 25 other tissues See more Orthologs mouse all
TMUB2, Official Symbol TMUB2provided by HGNC Official Full Name transmembrane and ubiquitin like domain containing 2provided by HGNC Primary source HGNC:HGNC:28459 See related Ensembl:ENSG00000168591 AllianceGenome:HGNC:28459 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FP2653 Summary Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 16.4), spleen (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
TMX1, Official Symbol TMX1provided by HGNC Official Full Name thioredoxin related transmembrane protein 1provided by HGNC Primary source HGNC:HGNC:15487 See related Ensembl:ENSG00000139921 MIM:610527; AllianceGenome:HGNC:15487 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMX; TXNDC; PDIA11; TXNDC1 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in urinary bladder (RPKM 15.6), colon (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
TMX2, Official Symbol TMX2provided by HGNC Official Full Name thioredoxin related transmembrane protein 2provided by HGNC Primary source HGNC:HGNC:30739 See related Ensembl:ENSG00000213593 MIM:616715; AllianceGenome:HGNC:30739 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIG26; CGI-31; PDIA12; NEDMCMS; TXNDC14 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in brain (RPKM 42.0), thyroid (RPKM 36.4) and 25 other tissues See more Orthologs mouse all
TMX2-CTNND1, Official Symbol TMX2-CTNND1provided by HGNC Official Full Name TMX2-CTNND1 readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:41992 See related Ensembl:ENSG00000288534 AllianceGenome:HGNC:41992 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAS; CTNND1; p120(cas); p120(ctn) Summary This locus represents naturally occurring read-through transcription between the neighboring TMX2 (thioredoxin-related transmembrane protein 2) and CTNND1 (catenin, cadherin-associated protein, delta 1) genes on chromosome 11. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in esophagus (RPKM 79.6), skin (RPKM 63.1) and 25 other tissues See more
TMX2P1, Official Symbol TMX2P1provided by HGNC Official Full Name thioredoxin related transmembrane protein 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49916 See related AllianceGenome:HGNC:49916 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TMX3, Official Symbol TMX3provided by HGNC Official Full Name thioredoxin related transmembrane protein 3provided by HGNC Primary source HGNC:HGNC:24718 See related Ensembl:ENSG00000166479 MIM:616102; AllianceGenome:HGNC:24718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDIA13; TXNDC10 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in appendix (RPKM 11.6), lymph node (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
TMX4, Official Symbol TMX4provided by HGNC Official Full Name thioredoxin related transmembrane protein 4provided by HGNC Primary source HGNC:HGNC:25237 See related Ensembl:ENSG00000125827 MIM:616766; AllianceGenome:HGNC:25237 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDIA14; TXNDC13; DJ971N18.2 Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017] Expression Broad expression in testis (RPKM 50.0), heart (RPKM 24.6) and 24 other tissues See more Orthologs mouse all
TNC, Official Symbol TNCprovided by HGNC Official Full Name tenascin Cprovided by HGNC Primary source HGNC:HGNC:5318 See related Ensembl:ENSG00000041982 MIM:187380; AllianceGenome:HGNC:5318 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225 Summary This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011] Expression Broad expression in appendix (RPKM 76.9), endometrium (RPKM 19.4) and 15 other tissues See more Orthologs mouse all
TNF, Official Symbol TNFprovided by HGNC Official Full Name tumor necrosis factorprovided by HGNC Primary source HGNC:HGNC:11892 See related Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha Summary This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Biased expression in bone marrow (RPKM 14.7), lymph node (RPKM 3.9) and 9 other tissues See more Orthologs mouse all
TNFAIP1, Official Symbol TNFAIP1provided by HGNC Official Full Name TNF alpha induced protein 1provided by HGNC Primary source HGNC:HGNC:11894 See related Ensembl:ENSG00000109079 MIM:191161; AllianceGenome:HGNC:11894 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B12; B61; EDP1; BTBD34; hBACURD2 Summary This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lung (RPKM 21.1), spleen (RPKM 20.2) and 25 other tissues See more Orthologs mouse all
TNFAIP2, Official Symbol TNFAIP2provided by HGNC Official Full Name TNF alpha induced protein 2provided by HGNC Primary source HGNC:HGNC:11895 See related Ensembl:ENSG00000185215 MIM:603300; AllianceGenome:HGNC:11895 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B94; EXOC3L3 Summary This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in urinary bladder (RPKM 54.5), spleen (RPKM 53.6) and 22 other tissues See more Orthologs mouse all
TNFAIP3, Official Symbol TNFAIP3provided by HGNC Official Full Name TNF alpha induced protein 3provided by HGNC Primary source HGNC:HGNC:11896 See related Ensembl:ENSG00000118503 MIM:191163; AllianceGenome:HGNC:11896 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A20; AISBL; AIFBL1; OTUD7C; TNFA1P2 Summary This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012] Expression Broad expression in bone marrow (RPKM 156.2), appendix (RPKM 61.9) and 14 other tissues See more Orthologs mouse all
TNFAIP6, Official Symbol TNFAIP6provided by HGNC Official Full Name TNF alpha induced protein 6provided by HGNC Primary source HGNC:HGNC:11898 See related Ensembl:ENSG00000123610 MIM:600410; AllianceGenome:HGNC:11898 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TSG6; TSG-6 Summary The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010] Expression Biased expression in appendix (RPKM 17.8), gall bladder (RPKM 12.0) and 11 other tissues See more Orthologs mouse all
TNFAIP8, Official Symbol TNFAIP8provided by HGNC Official Full Name TNF alpha induced protein 8provided by HGNC Primary source HGNC:HGNC:17260 See related Ensembl:ENSG00000145779 MIM:612111; AllianceGenome:HGNC:17260 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13 Summary Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues See more Orthologs mouse all
TNFAIP8L1, Official Symbol TNFAIP8L1provided by HGNC Official Full Name TNF alpha induced protein 8 like 1provided by HGNC Primary source HGNC:HGNC:28279 See related Ensembl:ENSG00000185361 MIM:615869; AllianceGenome:HGNC:28279 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIPE1 Summary Enables identical protein binding activity. Predicted to be involved in negative regulation of TOR signaling. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in liver (RPKM 6.4), spleen (RPKM 5.8) and 24 other tissues See more Orthologs mouse all
TNFAIP8L2, Official Symbol TNFAIP8L2provided by HGNC Official Full Name TNF alpha induced protein 8 like 2provided by HGNC Primary source HGNC:HGNC:26277 See related Ensembl:ENSG00000163154 MIM:612112; AllianceGenome:HGNC:26277 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIPE2 Summary Predicted to be involved in negative regulation of T cell activation and negative regulation of inflammatory response. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 30.0), lymph node (RPKM 26.2) and 14 other tissues See more Orthologs mouse all
TNFAIP8L3, Official Symbol TNFAIP8L3provided by HGNC Official Full Name TNF alpha induced protein 8 like 3provided by HGNC Primary source HGNC:HGNC:20620 See related Ensembl:ENSG00000183578 MIM:616438; AllianceGenome:HGNC:20620 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIPE3 Summary Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Predicted to be involved in several processes, including inositol lipid-mediated signaling; positive regulation of intracellular signal transduction; and positive regulation of phosphatidylinositol 3-kinase activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in endometrium (RPKM 16.6), esophagus (RPKM 6.5) and 15 other tissues See more Orthologs mouse all
TNFRSF10A, Official Symbol TNFRSF10Aprovided by HGNC Official Full Name TNF receptor superfamily member 10aprovided by HGNC Primary source HGNC:HGNC:11904 See related Ensembl:ENSG00000104689 MIM:603611; AllianceGenome:HGNC:11904 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DR4; APO2; CD261; TRAILR1; TRAILR-1 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 4.9), appendix (RPKM 4.2) and 24 other tissues See more Orthologs all
TNFRSF10B, Official Symbol TNFRSF10Bprovided by HGNC Official Full Name TNF receptor superfamily member 10bprovided by HGNC Primary source HGNC:HGNC:11905 See related Ensembl:ENSG00000120889 MIM:603612; AllianceGenome:HGNC:11905 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in gall bladder (RPKM 17.8), urinary bladder (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
TNFRSF10C, Official Symbol TNFRSF10Cprovided by HGNC Official Full Name TNF receptor superfamily member 10cprovided by HGNC Primary source HGNC:HGNC:11906 See related Ensembl:ENSG00000173535 MIM:603613; AllianceGenome:HGNC:11906 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 12.1), bone marrow (RPKM 9.2) and 17 other tissues See more Orthologs all
TNFRSF10D, Official Symbol TNFRSF10Dprovided by HGNC Official Full Name TNF receptor superfamily member 10dprovided by HGNC Primary source HGNC:HGNC:11907 See related Ensembl:ENSG00000173530 MIM:603614; AllianceGenome:HGNC:11907 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in gall bladder (RPKM 5.6), colon (RPKM 4.7) and 24 other tissues See more Orthologs all
TNFRSF11A, Official Symbol TNFRSF11Aprovided by HGNC Official Full Name TNF receptor superfamily member 11aprovided by HGNC Primary source HGNC:HGNC:11908 See related Ensembl:ENSG00000141655 MIM:603499; AllianceGenome:HGNC:11908 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; TRANCE-R Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012] Expression Biased expression in duodenum (RPKM 14.3), colon (RPKM 11.6) and 10 other tissues See more Orthologs mouse all
TNFRSF11B, Official Symbol TNFRSF11Bprovided by HGNC Official Full Name TNF receptor superfamily member 11bprovided by HGNC Primary source HGNC:HGNC:11909 See related Ensembl:ENSG00000164761 MIM:602643; AllianceGenome:HGNC:11909 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OPG; TR1; OCIF; PDB5 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in thyroid (RPKM 62.5), kidney (RPKM 16.2) and 7 other tissues See more Orthologs mouse all
TNFRSF12A, Official Symbol TNFRSF12Aprovided by HGNC Official Full Name TNF receptor superfamily member 12Aprovided by HGNC Primary source HGNC:HGNC:18152 See related Ensembl:ENSG00000006327 MIM:605914; AllianceGenome:HGNC:18152 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FN14; CD266; TWEAKR Summary Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 21.3), liver (RPKM 18.8) and 23 other tissues See more Orthologs mouse all
TNFRSF13B, Official Symbol TNFRSF13Bprovided by HGNC Official Full Name TNF receptor superfamily member 13Bprovided by HGNC Primary source HGNC:HGNC:18153 See related Ensembl:ENSG00000240505 MIM:604907; AllianceGenome:HGNC:18153 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CVID; RYZN; TACI; CD267; CVID2; IGAD2; TNFRSF14B Summary The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 10.1), lymph node (RPKM 5.1) and 6 other tissues See more Orthologs mouse all
TNFRSF13C, Official Symbol TNFRSF13Cprovided by HGNC Official Full Name TNF receptor superfamily member 13Cprovided by HGNC Primary source HGNC:HGNC:17755 See related Ensembl:ENSG00000159958 MIM:606269; AllianceGenome:HGNC:17755 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin Summary B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008] Expression Biased expression in spleen (RPKM 19.7), lymph node (RPKM 17.1) and 5 other tissues See more Orthologs mouse all
TNFRSF14, Official Symbol TNFRSF14provided by HGNC Official Full Name TNF receptor superfamily member 14provided by HGNC Primary source HGNC:HGNC:11912 See related Ensembl:ENSG00000157873 MIM:602746; AllianceGenome:HGNC:11912 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TR2; ATAR; HVEA; HVEM; CD270; LIGHTR Summary This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues See more Orthologs mouse all
TNFRSF14-AS1, Official Symbol TNFRSF14-AS1provided by HGNC Official Full Name TNFRSF14 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:26966 See related AllianceGenome:HGNC:26966 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in duodenum (RPKM 15.0), small intestine (RPKM 13.4) and 22 other tissues See more
TNFRSF17, Official Symbol TNFRSF17provided by HGNC Official Full Name TNF receptor superfamily member 17provided by HGNC Primary source HGNC:HGNC:11913 See related Ensembl:ENSG00000048462 MIM:109545; AllianceGenome:HGNC:11913 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCM; BCMA; CD269; TNFRSF13A Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 11.9), duodenum (RPKM 11.5) and 10 other tissues See more Orthologs mouse all
TNFRSF18, Official Symbol TNFRSF18provided by HGNC Official Full Name TNF receptor superfamily member 18provided by HGNC Primary source HGNC:HGNC:11914 See related Ensembl:ENSG00000186891 MIM:603905; AllianceGenome:HGNC:11914 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AITR; GITR; CD357; GITR-D; ENERGEN Summary This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] Expression Biased expression in skin (RPKM 4.0), appendix (RPKM 1.0) and 12 other tissues See more Orthologs mouse all
TNFRSF19, Official Symbol TNFRSF19provided by HGNC Official Full Name TNF receptor superfamily member 19provided by HGNC Primary source HGNC:HGNC:11915 See related Ensembl:ENSG00000127863 MIM:606122; AllianceGenome:HGNC:11915 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAJ; TROY; TRADE; TAJ-alpha Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 37.6), prostate (RPKM 12.9) and 8 other tissues See more Orthologs mouse all
TNFRSF1A, Official Symbol TNFRSF1Aprovided by HGNC Official Full Name TNF receptor superfamily member 1Aprovided by HGNC Primary source HGNC:HGNC:11916 See related Ensembl:ENSG00000067182 MIM:191190; AllianceGenome:HGNC:11916 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55 Summary This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in small intestine (RPKM 52.0), gall bladder (RPKM 48.9) and 25 other tissues See more Orthologs mouse all
TNFRSF1B, Official Symbol TNFRSF1Bprovided by HGNC Official Full Name TNF receptor superfamily member 1Bprovided by HGNC Primary source HGNC:HGNC:11917 See related Ensembl:ENSG00000028137 MIM:191191; AllianceGenome:HGNC:11917 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 31.9), spleen (RPKM 25.2) and 23 other tissues See more Orthologs mouse all
TNFRSF21, Official Symbol TNFRSF21provided by HGNC Official Full Name TNF receptor superfamily member 21provided by HGNC Primary source HGNC:HGNC:13469 See related Ensembl:ENSG00000146072 MIM:605732; AllianceGenome:HGNC:13469 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DR6; CD358; BM-018 Summary This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013] Expression Broad expression in urinary bladder (RPKM 50.6), fat (RPKM 36.4) and 23 other tissues See more Orthologs mouse all
TNFRSF25, Official Symbol TNFRSF25provided by HGNC Official Full Name TNF receptor superfamily member 25provided by HGNC Primary source HGNC:HGNC:11910 See related Ensembl:ENSG00000215788 MIM:603366; AllianceGenome:HGNC:11910 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008] Expression Broad expression in skin (RPKM 23.6), spleen (RPKM 13.2) and 19 other tissues See more Orthologs mouse all