psui3905/ncbi_genes_summary huggingface dataset:
FGF12, Official Symbol FGF12provided by HGNC Official Full Name fibroblast growth factor 12provided by HGNC Primary source HGNC:HGNC:3668 See related Ensembl:ENSG00000114279 MIM:601513; AllianceGenome:HGNC:3668 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHF1; DEE47; EIEE47; FGF12B Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. [provided by RefSeq, Dec 2019] Expression Biased expression in heart (RPKM 20.8), brain (RPKM 14.1) and 2 other tissues See more Orthologs mouse all
FGF12-AS1, Official Symbol FGF12-AS1provided by HGNC Official Full Name FGF12 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40234 See related Ensembl:ENSG00000231383 AllianceGenome:HGNC:40234 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FGF12-AS2, Official Symbol FGF12-AS2provided by HGNC Official Full Name FGF12 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40235 See related Ensembl:ENSG00000230126 AllianceGenome:HGNC:40235 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FGF12-AS3, Official Symbol FGF12-AS3provided by HGNC Official Full Name FGF12 antisense RNA 3provided by HGNC Primary source HGNC:HGNC:40236 See related AllianceGenome:HGNC:40236 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release Expression Low expression observed in reference dataset See more
FGF13, Official Symbol FGF13provided by HGNC Official Full Name fibroblast growth factor 13provided by HGNC Primary source HGNC:HGNC:3670 See related Ensembl:ENSG00000129682 MIM:300070; AllianceGenome:HGNC:3670 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FGF2; FHF2; DEE90; FHF-2; FGF-13; XLID110; LINC00889 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008] Expression Broad expression in brain (RPKM 11.3), fat (RPKM 6.2) and 21 other tissues See more Orthologs mouse all
FGF13-AS1, Official Symbol FGF13-AS1provided by HGNC Official Full Name FGF13 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44264 See related Ensembl:ENSG00000226031 MIM:301087; AllianceGenome:HGNC:44264 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in fat (RPKM 1.6), bone marrow (RPKM 0.4) and 16 other tissues See more
FGF14, Official Symbol FGF14provided by HGNC Official Full Name fibroblast growth factor 14provided by HGNC Primary source HGNC:HGNC:3671 See related Ensembl:ENSG00000102466 MIM:601515; AllianceGenome:HGNC:3671 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHF4; NYS4; FHF-4; SCA27; FGF-14; SCA27A; SCA27B Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 5.0), adrenal (RPKM 1.3) and 6 other tissues See more Orthologs mouse all
FGF14-AS1, Official Symbol FGF14-AS1provided by HGNC Official Full Name FGF14 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40237 See related Ensembl:ENSG00000234445 AllianceGenome:HGNC:40237 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.2) See more
FGF14-AS2, Official Symbol FGF14-AS2provided by HGNC Official Full Name FGF14 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:44368 See related Ensembl:ENSG00000272143 AllianceGenome:HGNC:44368 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FGF14-IT1, Official Symbol FGF14-IT1provided by HGNC Official Full Name FGF14 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:42774 See related Ensembl:ENSG00000243319 AllianceGenome:HGNC:42774 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 3.3) See more
FGF16, Official Symbol FGF16provided by HGNC Official Full Name fibroblast growth factor 16provided by HGNC Primary source HGNC:HGNC:3672 See related Ensembl:ENSG00000196468 MIM:300827; AllianceGenome:HGNC:3672 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MF4; FGF-16 Summary This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF17, Official Symbol FGF17provided by HGNC Official Full Name fibroblast growth factor 17provided by HGNC Primary source HGNC:HGNC:3673 See related Ensembl:ENSG00000158815 MIM:603725; AllianceGenome:HGNC:3673 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HH20; FGF-13; FGF-17 Summary This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF18, Official Symbol FGF18provided by HGNC Official Full Name fibroblast growth factor 18provided by HGNC Primary source HGNC:HGNC:3674 See related Ensembl:ENSG00000156427 MIM:603726; AllianceGenome:HGNC:3674 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZFGF5; FGF-18 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 3.7), lung (RPKM 0.9) and 12 other tissues See more Orthologs mouse all
FGF19, Official Symbol FGF19provided by HGNC Official Full Name fibroblast growth factor 19provided by HGNC Primary source HGNC:HGNC:3675 See related Ensembl:ENSG00000162344 MIM:603891; AllianceGenome:HGNC:3675 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008] Expression Restricted expression toward gall bladder (RPKM 132.5) See more Orthologs mouse all
FGF2, Official Symbol FGF2provided by HGNC Official Full Name fibroblast growth factor 2provided by HGNC Primary source HGNC:HGNC:3676 See related Ensembl:ENSG00000138685 MIM:134920; AllianceGenome:HGNC:3676 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BFGF; FGFB; FGF-2; HBGF-2 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 17.2), endometrium (RPKM 8.8) and 21 other tissues See more Orthologs mouse all
FGF20, Official Symbol FGF20provided by HGNC Official Full Name fibroblast growth factor 20provided by HGNC Primary source HGNC:HGNC:3677 See related Ensembl:ENSG00000078579 MIM:605558; AllianceGenome:HGNC:3677 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHDA2; FGF-20 Summary The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF21, Official Symbol FGF21provided by HGNC Official Full Name fibroblast growth factor 21provided by HGNC Primary source HGNC:HGNC:3678 See related Ensembl:ENSG00000105550 MIM:609436; AllianceGenome:HGNC:3678 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016] Expression Restricted expression toward liver (RPKM 3.0) See more Orthologs mouse all
FGF22, Official Symbol FGF22provided by HGNC Official Full Name fibroblast growth factor 22provided by HGNC Primary source HGNC:HGNC:3679 See related Ensembl:ENSG00000070388 MIM:605831; AllianceGenome:HGNC:3679 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Expression Biased expression in skin (RPKM 1.5), brain (RPKM 0.4) and 7 other tissues See more Orthologs mouse all
FGF23, Official Symbol FGF23provided by HGNC Official Full Name fibroblast growth factor 23provided by HGNC Primary source HGNC:HGNC:3680 See related Ensembl:ENSG00000118972 MIM:605380; AllianceGenome:HGNC:3680 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC Summary This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF3, Official Symbol FGF3provided by HGNC Official Full Name fibroblast growth factor 3provided by HGNC Primary source HGNC:HGNC:3681 See related Ensembl:ENSG00000186895 MIM:164950; AllianceGenome:HGNC:3681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INT2; HBGF-3 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF4, Official Symbol FGF4provided by HGNC Official Full Name fibroblast growth factor 4provided by HGNC Primary source HGNC:HGNC:3682 See related Ensembl:ENSG00000075388 MIM:164980; AllianceGenome:HGNC:3682 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF5, Official Symbol FGF5provided by HGNC Official Full Name fibroblast growth factor 5provided by HGNC Primary source HGNC:HGNC:3683 See related Ensembl:ENSG00000138675 MIM:165190; AllianceGenome:HGNC:3683 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBGF-5; TCMGLY; Smag-82 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in gall bladder (RPKM 2.1), kidney (RPKM 0.5) and 2 other tissues See more Orthologs mouse all
FGF6, Official Symbol FGF6provided by HGNC Official Full Name fibroblast growth factor 6provided by HGNC Primary source HGNC:HGNC:3684 See related Ensembl:ENSG00000111241 MIM:134921; AllianceGenome:HGNC:3684 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HST2; HBGF-6 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF7, Official Symbol FGF7provided by HGNC Official Full Name fibroblast growth factor 7provided by HGNC Primary source HGNC:HGNC:3685 See related Ensembl:ENSG00000140285 MIM:148180; AllianceGenome:HGNC:3685 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KGF; HBGF-7 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008] Expression Broad expression in gall bladder (RPKM 32.8), urinary bladder (RPKM 19.9) and 15 other tissues See more Orthologs mouse all
FGF7P3, Official Symbol FGF7P3provided by HGNC Official Full Name fibroblast growth factor 7 pseudogene 3provided by HGNC Primary source HGNC:HGNC:26671 See related AllianceGenome:HGNC:26671 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KGFLP2 Expression Ubiquitous expression in thyroid (RPKM 5.6), brain (RPKM 4.5) and 24 other tissues See more
FGF7P7, Official Symbol FGF7P7provided by HGNC Official Full Name fibroblast growth factor 7 pseudogene 7provided by HGNC Primary source HGNC:HGNC:33589 See related AllianceGenome:HGNC:33589 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FGF8, Official Symbol FGF8provided by HGNC Official Full Name fibroblast growth factor 8provided by HGNC Primary source HGNC:HGNC:3686 See related Ensembl:ENSG00000107831 MIM:600483; AllianceGenome:HGNC:3686 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HH6; AIGF; KAL6; FGF-8; HBGF-8 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
FGF9, Official Symbol FGF9provided by HGNC Official Full Name fibroblast growth factor 9provided by HGNC Primary source HGNC:HGNC:3687 See related Ensembl:ENSG00000102678 MIM:600921; AllianceGenome:HGNC:3687 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAF; FGF-9; SYNS3; HBFG-9; HBGF-9 Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 6.4), adrenal (RPKM 2.1) and 10 other tissues See more Orthologs mouse all
FGFBP1, Official Symbol FGFBP1provided by HGNC Official Full Name fibroblast growth factor binding protein 1provided by HGNC Primary source HGNC:HGNC:19695 See related Ensembl:ENSG00000137440 MIM:607737; AllianceGenome:HGNC:19695 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FGFBP; HBP17; FGF-BP; FGF-BP1; FGFBP-1 Summary This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] Expression Biased expression in esophagus (RPKM 137.5), skin (RPKM 14.8) and 1 other tissue See more Orthologs mouse all
FGFBP2, Official Symbol FGFBP2provided by HGNC Official Full Name fibroblast growth factor binding protein 2provided by HGNC Primary source HGNC:HGNC:29451 See related Ensembl:ENSG00000137441 MIM:607713; AllianceGenome:HGNC:29451 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KSP37; HBP17RP Summary This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008] Expression Biased expression in bone marrow (RPKM 17.7), spleen (RPKM 6.7) and 7 other tissues See more Orthologs all
FGFBP3, Official Symbol FGFBP3provided by HGNC Official Full Name fibroblast growth factor binding protein 3provided by HGNC Primary source HGNC:HGNC:23428 See related Ensembl:ENSG00000174721 AllianceGenome:HGNC:23428 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FGF-BP3; C10orf13 Summary Enables fibroblast growth factor binding activity and heparin binding activity. Acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway and positive regulation of vascular permeability. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 6.6), prostate (RPKM 0.9) and 13 other tissues See more Orthologs mouse all
FGFR1, Official Symbol FGFR1provided by HGNC Official Full Name fibroblast growth factor receptor 1provided by HGNC Primary source HGNC:HGNC:3688 See related Ensembl:ENSG00000077782 MIM:136350; AllianceGenome:HGNC:3688 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1 Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 21.8), fat (RPKM 21.4) and 25 other tissues See more Orthologs mouse all
FGFR1OP2, Official Symbol FGFR1OP2provided by HGNC Official Full Name FGFR1 oncogene partner 2provided by HGNC Primary source HGNC:HGNC:23098 See related Ensembl:ENSG00000111790 MIM:608858; AllianceGenome:HGNC:23098 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WIT3.0; HSPC123-like Summary Predicted to enable identical protein binding activity. Predicted to be involved in response to wounding. Predicted to act upstream of or within wound healing. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 23.0), adrenal (RPKM 22.0) and 25 other tissues See more Orthologs mouse all
FGFR2, Official Symbol FGFR2provided by HGNC Official Full Name fibroblast growth factor receptor 2provided by HGNC Primary source HGNC:HGNC:3689 See related Ensembl:ENSG00000066468 MIM:176943; AllianceGenome:HGNC:3689 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] Expression Broad expression in skin (RPKM 22.1), thyroid (RPKM 14.8) and 20 other tissues See more Orthologs mouse all
FGFR3, Official Symbol FGFR3provided by HGNC Official Full Name fibroblast growth factor receptor 3provided by HGNC Primary source HGNC:HGNC:3690 See related Ensembl:ENSG00000068078 MIM:134934; AllianceGenome:HGNC:3690 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACH; CEK2; JTK4; CD333; HSFGFR3EX Summary This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017] Expression Biased expression in skin (RPKM 120.7), esophagus (RPKM 18.0) and 8 other tissues See more Orthologs mouse all
FGFR3P1, Official Symbol FGFR3P1provided by HGNC Official Full Name fibroblast growth factor receptor 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:21664 See related AllianceGenome:HGNC:21664 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FGFR6; FGFR3P; D84394.2
FGFR3P6, Official Symbol FGFR3P6provided by HGNC Official Full Name fibroblast growth factor receptor 3 pseudogene 6provided by HGNC Primary source HGNC:HGNC:37951 See related Ensembl:ENSG00000226164 AllianceGenome:HGNC:37951 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FGFR4, Official Symbol FGFR4provided by HGNC Official Full Name fibroblast growth factor receptor 4provided by HGNC Primary source HGNC:HGNC:3691 See related Ensembl:ENSG00000160867 MIM:134935; AllianceGenome:HGNC:3691 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TKF; JTK2; CD334 Summary The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017] Expression Broad expression in lung (RPKM 16.7), kidney (RPKM 12.5) and 15 other tissues See more Orthologs mouse all
FGFRL1, Official Symbol FGFRL1provided by HGNC Official Full Name fibroblast growth factor receptor like 1provided by HGNC Primary source HGNC:HGNC:3693 See related Ensembl:ENSG00000127418 MIM:605830; AllianceGenome:HGNC:3693 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHFR; FGFR5; FGFR-5 Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 21.2), fat (RPKM 15.4) and 25 other tissues See more Orthologs mouse all
FGG, Official Symbol FGGprovided by HGNC Official Full Name fibrinogen gamma chainprovided by HGNC Primary source HGNC:HGNC:3694 See related Ensembl:ENSG00000171557 MIM:134850; AllianceGenome:HGNC:3694 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] Expression Restricted expression toward liver (RPKM 3614.5) See more Orthologs mouse all
FGGY, Official Symbol FGGYprovided by HGNC Official Full Name FGGY carbohydrate kinase domain containingprovided by HGNC Primary source HGNC:HGNC:25610 See related Ensembl:ENSG00000172456 MIM:611370; AllianceGenome:HGNC:25610 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] Expression Ubiquitous expression in liver (RPKM 2.1), kidney (RPKM 1.3) and 25 other tissues See more Orthologs mouse all
FGGY-DT, Official Symbol FGGY-DTprovided by HGNC Official Full Name FGGY divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55265 See related AllianceGenome:HGNC:55265 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FGL1, Official Symbol FGL1provided by HGNC Official Full Name fibrinogen like 1provided by HGNC Primary source HGNC:HGNC:3695 See related Ensembl:ENSG00000104760 MIM:605776; AllianceGenome:HGNC:3695 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPS; HFREP1; HP-041; LFIRE1; LFIRE-1 Summary Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 275.4) See more Orthologs mouse all
FGL2, Official Symbol FGL2provided by HGNC Official Full Name fibrinogen like 2provided by HGNC Primary source HGNC:HGNC:3696 See related Ensembl:ENSG00000127951 MIM:605351; AllianceGenome:HGNC:3696 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T49; pT49 Summary The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 83.3), appendix (RPKM 61.0) and 22 other tissues See more Orthologs mouse all
FGR, Official Symbol FGRprovided by HGNC Official Full Name FGR proto-oncogene, Src family tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:3697 See related Ensembl:ENSG00000000938 MIM:164940; AllianceGenome:HGNC:3697 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr Summary This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues See more Orthologs mouse all