psui3905/ncbi_genes_summary huggingface dataset:
EGR3, Official Symbol EGR3provided by HGNC Official Full Name early growth response 3provided by HGNC Primary source HGNC:HGNC:3240 See related Ensembl:ENSG00000179388 MIM:602419; AllianceGenome:HGNC:3240 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EGR-3; PILOT Summary This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010] Expression Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues See more Orthologs mouse all
EGR4, Official Symbol EGR4provided by HGNC Official Full Name early growth response 4provided by HGNC Primary source HGNC:HGNC:3241 See related Ensembl:ENSG00000135625 MIM:128992; AllianceGenome:HGNC:3241 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AT133; NGFIC; NGFI-C; PAT133 Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 3.5) and testis (RPKM 1.6) See more Orthologs mouse all
EHBP1, Official Symbol EHBP1provided by HGNC Official Full Name EH domain binding protein 1provided by HGNC Primary source HGNC:HGNC:29144 See related Ensembl:ENSG00000115504 MIM:609922; AllianceGenome:HGNC:29144 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPC12; NACSIN Summary This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] Expression Ubiquitous expression in ovary (RPKM 15.6), fat (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
EHBP1L1, Official Symbol EHBP1L1provided by HGNC Official Full Name EH domain binding protein 1 like 1provided by HGNC Primary source HGNC:HGNC:30682 See related Ensembl:ENSG00000173442 MIM:619583; AllianceGenome:HGNC:30682 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in actin cytoskeleton organization. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 34.0), appendix (RPKM 32.9) and 24 other tissues See more Orthologs mouse all
EHD1, Official Symbol EHD1provided by HGNC Official Full Name EH domain containing 1provided by HGNC Primary source HGNC:HGNC:3242 See related Ensembl:ENSG00000110047 MIM:605888; AllianceGenome:HGNC:3242 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAST; PAST1; H-PAST; HPAST1 Summary This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] Expression Broad expression in bone marrow (RPKM 39.6), testis (RPKM 32.1) and 24 other tissues See more Orthologs mouse all
EHD2, Official Symbol EHD2provided by HGNC Official Full Name EH domain containing 2provided by HGNC Primary source HGNC:HGNC:3243 See related Ensembl:ENSG00000024422 MIM:605890; AllianceGenome:HGNC:3243 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAST2 Summary This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008] Expression Broad expression in fat (RPKM 140.8), lung (RPKM 41.0) and 18 other tissues See more Orthologs mouse all
EHD3, Official Symbol EHD3provided by HGNC Official Full Name EH domain containing 3provided by HGNC Primary source HGNC:HGNC:3244 See related Ensembl:ENSG00000013016 MIM:605891; AllianceGenome:HGNC:3244 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAST3 Summary Predicted to enable nucleic acid binding activity. Involved in several processes, including Golgi to lysosome transport; endosomal transport; and protein homooligomerization. Acts upstream of or within protein localization to plasma membrane and regulation of cardiac muscle cell membrane potential. Located in ciliary pocket membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 25.4), esophagus (RPKM 14.7) and 17 other tissues See more Orthologs mouse all
EHD4, Official Symbol EHD4provided by HGNC Official Full Name EH domain containing 4provided by HGNC Primary source HGNC:HGNC:3245 See related Ensembl:ENSG00000103966 MIM:605892; AllianceGenome:HGNC:3245 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAST4 Summary Enables cadherin binding activity. Involved in endocytic recycling and protein homooligomerization. Located in endoplasmic reticulum and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in urinary bladder (RPKM 15.6), gall bladder (RPKM 14.3) and 25 other tissues See more Orthologs mouse all
EHD4-AS1, Official Symbol EHD4-AS1provided by HGNC Official Full Name EHD4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51418 See related Ensembl:ENSG00000259883 AllianceGenome:HGNC:51418 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
EHF, Official Symbol EHFprovided by HGNC Official Full Name ETS homologous factorprovided by HGNC Primary source HGNC:HGNC:3246 See related Ensembl:ENSG00000135373 MIM:605439; AllianceGenome:HGNC:3246 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESE3; ESEJ; ESE3B Summary This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] Expression Biased expression in esophagus (RPKM 89.9), colon (RPKM 60.6) and 12 other tissues See more Orthologs mouse all
EHHADH, Official Symbol EHHADHprovided by HGNC Official Full Name enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenaseprovided by HGNC Primary source HGNC:HGNC:3247 See related Ensembl:ENSG00000113790 MIM:607037; AllianceGenome:HGNC:3247 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LBP; ECHD; LBFP; MFE1; PBFE; FRTS3; L-PBE Summary The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Biased expression in liver (RPKM 75.1), kidney (RPKM 65.6) and 8 other tissues See more Orthologs mouse all
EHHADH-AS1, Official Symbol EHHADH-AS1provided by HGNC Official Full Name EHHADH antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44133 See related Ensembl:ENSG00000223358 AllianceGenome:HGNC:44133 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in kidney (RPKM 35.8), liver (RPKM 26.1) and 12 other tissues See more
EHMT1, Official Symbol EHMT1provided by HGNC Official Full Name euchromatic histone lysine methyltransferase 1provided by HGNC Primary source HGNC:HGNC:24650 See related Ensembl:ENSG00000181090 MIM:607001; AllianceGenome:HGNC:24650 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GLP; GLP1; KMT1D; KLEFS1; FP13812; EHMT1-IT1; EUHMTASE1; Eu-HMTase1 Summary The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in testis (RPKM 9.7), spleen (RPKM 7.2) and 25 other tissues See more Orthologs mouse all
EHMT2, Official Symbol EHMT2provided by HGNC Official Full Name euchromatic histone lysine methyltransferase 2provided by HGNC Primary source HGNC:HGNC:14129 See related Ensembl:ENSG00000204371 MIM:604599; AllianceGenome:HGNC:14129 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G9A; BAT8; GAT8; NG36; KMT1C; C6orf30 Summary This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in ovary (RPKM 14.8), testis (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
EHMT2-AS1, Official Symbol EHMT2-AS1provided by HGNC Official Full Name EHMT2 and SLC44A4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39751 See related Ensembl:ENSG00000237080 AllianceGenome:HGNC:39751 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 6.1) and 25 other tissues See more
EI24, Official Symbol EI24provided by HGNC Official Full Name EI24 autophagy associated transmembrane proteinprovided by HGNC Primary source HGNC:HGNC:13276 See related Ensembl:ENSG00000149547 MIM:605170; AllianceGenome:HGNC:13276 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPG4; PIG8; TP53I8 Summary This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in liver (RPKM 39.6), colon (RPKM 30.4) and 25 other tissues See more Orthologs mouse all
EI24P1, Official Symbol EI24P1provided by HGNC Official Full Name EI24 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44586 See related Ensembl:ENSG00000236357 AllianceGenome:HGNC:44586 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EID1, Official Symbol EID1provided by HGNC Official Full Name EP300 interacting inhibitor of differentiation 1provided by HGNC Primary source HGNC:HGNC:1191 See related Ensembl:ENSG00000255302 MIM:605894; AllianceGenome:HGNC:1191 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620 Summary Enables histone acetyltransferase binding activity and histone acetyltransferase regulator activity. Involved in cell differentiation and negative regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasmic ribonucleoprotein granule and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
EID2, Official Symbol EID2provided by HGNC Official Full Name EP300 interacting inhibitor of differentiation 2provided by HGNC Primary source HGNC:HGNC:28292 See related Ensembl:ENSG00000176396 MIM:609773; AllianceGenome:HGNC:28292 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRI2; EID-2 Summary Enables SMAD binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta receptor signaling pathway; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
EID2B, Official Symbol EID2Bprovided by HGNC Official Full Name EP300 interacting inhibitor of differentiation 2Bprovided by HGNC Primary source HGNC:HGNC:26796 See related Ensembl:ENSG00000176401 MIM:617355; AllianceGenome:HGNC:26796 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EID-3; EID-2B Summary Enables identical protein binding activity. Involved in negative regulation of myoblast differentiation and negative regulation of transcription, DNA-templated. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
EID3, Official Symbol EID3provided by HGNC Official Full Name EP300 interacting inhibitor of differentiation 3provided by HGNC Primary source HGNC:HGNC:32961 See related Ensembl:ENSG00000255150 MIM:612986; AllianceGenome:HGNC:32961 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NS4EB; NSE4B; NSMCE4B Summary Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
EIF1, Official Symbol EIF1provided by HGNC Official Full Name eukaryotic translation initiation factor 1provided by HGNC Primary source HGNC:HGNC:3249 See related Ensembl:ENSG00000173812 MIM:619901; AllianceGenome:HGNC:3249 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A121; ISO1; SUI1; EIF-1; EIF1A Summary Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 681.9), fat (RPKM 274.0) and 25 other tissues See more Orthologs mouse all
EIF1AD, Official Symbol EIF1ADprovided by HGNC Official Full Name eukaryotic translation initiation factor 1A domain containingprovided by HGNC Primary source HGNC:HGNC:28147 See related Ensembl:ENSG00000175376 MIM:618473; AllianceGenome:HGNC:28147 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OBELIX; haponin Summary Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 7.6), testis (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
EIF1AX, Official Symbol EIF1AXprovided by HGNC Official Full Name eukaryotic translation initiation factor 1A X-linkedprovided by HGNC Primary source HGNC:HGNC:3250 See related Ensembl:ENSG00000173674 MIM:300186; AllianceGenome:HGNC:3250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1 Summary This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 20.5), endometrium (RPKM 20.0) and 25 other tissues See more Orthologs mouse all
EIF1AX-AS1, Official Symbol EIF1AX-AS1provided by HGNC Official Full Name EIF1AX antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40208 See related Ensembl:ENSG00000225037 AllianceGenome:HGNC:40208 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
EIF1AXP1, Official Symbol EIF1AXP1provided by HGNC Official Full Name EIF1AX pseudogene 1provided by HGNC Primary source HGNC:HGNC:19900 See related AllianceGenome:HGNC:19900 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF1AP1
EIF1AXP2, Official Symbol EIF1AXP2provided by HGNC Official Full Name EIF1AX pseudogene 2provided by HGNC Primary source HGNC:HGNC:44295 See related Ensembl:ENSG00000258980 AllianceGenome:HGNC:44295 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF1AY, Official Symbol EIF1AYprovided by HGNC Official Full Name eukaryotic translation initiation factor 1A Y-linkedprovided by HGNC Primary source HGNC:HGNC:3252 See related Ensembl:ENSG00000198692 MIM:400014; AllianceGenome:HGNC:3252 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as eIF-4C Summary This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Broad expression in bone marrow (RPKM 13.9), prostate (RPKM 13.1) and 20 other tissues See more Orthologs all
EIF1B, Official Symbol EIF1Bprovided by HGNC Official Full Name eukaryotic translation initiation factor 1Bprovided by HGNC Primary source HGNC:HGNC:30792 See related Ensembl:ENSG00000114784 AllianceGenome:HGNC:30792 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GC20 Summary Enables RNA binding activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 113.1), bone marrow (RPKM 72.6) and 25 other tissues See more Orthologs mouse all
EIF1B-AS1, Official Symbol EIF1B-AS1provided by HGNC Official Full Name EIF1B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44555 See related Ensembl:ENSG00000280739 AllianceGenome:HGNC:44555 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
EIF1P3, Official Symbol EIF1P3provided by HGNC Official Full Name eukaryotic translation initiation factor 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:49616 See related AllianceGenome:HGNC:49616 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF1P5, Official Symbol EIF1P5provided by HGNC Official Full Name eukaryotic translation initiation factor 1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:49618 See related Ensembl:ENSG00000266563 AllianceGenome:HGNC:49618 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF1P6, Official Symbol EIF1P6provided by HGNC Official Full Name eukaryotic translation initiation factor 1 pseudogene 6provided by HGNC Primary source HGNC:HGNC:49619 See related AllianceGenome:HGNC:49619 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF1P7, Official Symbol EIF1P7provided by HGNC Official Full Name eukaryotic translation initiation factor 1 pseudogene 7provided by HGNC Primary source HGNC:HGNC:49620 See related AllianceGenome:HGNC:49620 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF2A, Official Symbol EIF2Aprovided by HGNC Official Full Name eukaryotic translation initiation factor 2Aprovided by HGNC Primary source HGNC:HGNC:3254 See related Ensembl:ENSG00000144895 MIM:609234; AllianceGenome:HGNC:3254 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDA02; EIF-2A; MST089; MSTP004; MSTP089 Summary This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Annotation information Note: EIF2A (Gene ID: 83939) and EIF2S1 (Gene ID: 1965) share the EIF2A symbol/alias in common. EIF2A is a widely used alternative name for eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), which can be confused with the official symbol for eukaryotic translation initiation factor 2A (EIF2A). [05 Jul 2018] Expression Ubiquitous expression in thyroid (RPKM 30.8), ovary (RPKM 23.5) and 25 other tissues See more Orthologs mouse all
EIF2AK1, Official Symbol EIF2AK1provided by HGNC Official Full Name eukaryotic translation initiation factor 2 alpha kinase 1provided by HGNC Primary source HGNC:HGNC:24921 See related Ensembl:ENSG00000086232 MIM:613635; AllianceGenome:HGNC:24921 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCR; HRI; hHRI; LEMSPAD Summary The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Expression Ubiquitous expression in bone marrow (RPKM 37.9), placenta (RPKM 32.2) and 25 other tissues See more Orthologs mouse all
EIF2AK2, Official Symbol EIF2AK2provided by HGNC Official Full Name eukaryotic translation initiation factor 2 alpha kinase 2provided by HGNC Primary source HGNC:HGNC:9437 See related Ensembl:ENSG00000055332 MIM:176871; AllianceGenome:HGNC:9437 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKR; PRKR; DYT33; LEUDEN; EIF2AK1; PPP1R83 Summary The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in bone marrow (RPKM 8.7), brain (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
EIF2AK3, Official Symbol EIF2AK3provided by HGNC Official Full Name eukaryotic translation initiation factor 2 alpha kinase 3provided by HGNC Primary source HGNC:HGNC:3255 See related Ensembl:ENSG00000172071 MIM:604032; AllianceGenome:HGNC:3255 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PEK; WRS; PERK Summary The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in thyroid (RPKM 13.4), stomach (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
EIF2AK3-DT, Official Symbol EIF2AK3-DTprovided by HGNC Official Full Name EIF2AK3 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:54066 See related Ensembl:ENSG00000234028 AllianceGenome:HGNC:54066 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in lymph node (RPKM 1.3), ovary (RPKM 1.0) and 25 other tissues See more
EIF2AK4, Official Symbol EIF2AK4provided by HGNC Official Full Name eukaryotic translation initiation factor 2 alpha kinase 4provided by HGNC Primary source HGNC:HGNC:19687 See related Ensembl:ENSG00000128829 MIM:609280; AllianceGenome:HGNC:19687 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GCN2; PVOD2 Summary This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in prostate (RPKM 9.5), thyroid (RPKM 9.2) and 25 other tissues See more Orthologs mouse all
EIF2AP4, Official Symbol EIF2AP4provided by HGNC Official Full Name eukaryotic translation initiation factor 2A pseudogene 4provided by HGNC Primary source HGNC:HGNC:39498 See related Ensembl:ENSG00000227395 AllianceGenome:HGNC:39498 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
EIF2B1, Official Symbol EIF2B1provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit alphaprovided by HGNC Primary source HGNC:HGNC:3257 See related Ensembl:ENSG00000111361 MIM:606686; AllianceGenome:HGNC:3257 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWM1; EIF2B; EIF2BA; EIF2Balpha Summary This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in lymph node (RPKM 22.1), skin (RPKM 20.5) and 25 other tissues See more Orthologs mouse all
EIF2B2, Official Symbol EIF2B2provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit betaprovided by HGNC Primary source HGNC:HGNC:3258 See related Ensembl:ENSG00000119718 MIM:606454; AllianceGenome:HGNC:3258 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWM2; EIF2B; EIF2Bbeta; EIF-2Bbeta Summary This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in thyroid (RPKM 32.7), adrenal (RPKM 18.1) and 25 other tissues See more Orthologs mouse all
EIF2B3, Official Symbol EIF2B3provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit gammaprovided by HGNC Primary source HGNC:HGNC:3259 See related Ensembl:ENSG00000070785 MIM:606273; AllianceGenome:HGNC:3259 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWM3; EIF-2B; EIF2Bgamma Summary The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in fat (RPKM 9.9), testis (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
EIF2B4, Official Symbol EIF2B4provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit deltaprovided by HGNC Primary source HGNC:HGNC:3260 See related Ensembl:ENSG00000115211 MIM:606687; AllianceGenome:HGNC:3260 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VWM4; EIF2B; EIF-2B; EIF2Bdelta Summary Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 20.0), prostate (RPKM 13.7) and 25 other tissues See more Orthologs mouse all
EIF2B5, Official Symbol EIF2B5provided by HGNC Official Full Name eukaryotic translation initiation factor 2B subunit epsilonprovided by HGNC Primary source HGNC:HGNC:3261 See related Ensembl:ENSG00000145191 MIM:603945; AllianceGenome:HGNC:3261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLE; CACH; LVWM; VWM5; EIF-2B; EIF2Bepsilon Summary This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009] Expression Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
EIF2B5-DT, Official Symbol EIF2B5-DTprovided by HGNC Official Full Name EIF2B5 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55202 See related AllianceGenome:HGNC:55202 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
EIF2D, Official Symbol EIF2Dprovided by HGNC Official Full Name eukaryotic translation initiation factor 2Dprovided by HGNC Primary source HGNC:HGNC:6583 See related Ensembl:ENSG00000143486 MIM:613709; AllianceGenome:HGNC:6583 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LGTN; HCA56 Summary This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Annotation information Note: The name of this locus was changed from ligatin to eukaryotic translation initiation factor 2D based on the gene characterization reported in PMID:20566627. [18 Aug 2011] Expression Ubiquitous expression in ovary (RPKM 12.2), thyroid (RPKM 9.1) and 25 other tissues See more Orthologs mouse all
EIF2S1, Official Symbol EIF2S1provided by HGNC Official Full Name eukaryotic translation initiation factor 2 subunit alphaprovided by HGNC Primary source HGNC:HGNC:3265 See related Ensembl:ENSG00000134001 MIM:603907; AllianceGenome:HGNC:3265 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha Summary The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010] Annotation information Note: EIF2A (Gene ID: 83939) and EIF2S1 (Gene ID: 1965) share the EIF2A symbol/alias in common. EIF2A is a widely used alternative name for eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), which can be confused with the official symbol for eukaryotic translation initiation factor 2A (EIF2A). [05 Jul 2018] Expression Ubiquitous expression in testis (RPKM 19.0), esophagus (RPKM 15.6) and 25 other tissues See more Orthologs mouse all
EIF2S2, Official Symbol EIF2S2provided by HGNC Official Full Name eukaryotic translation initiation factor 2 subunit betaprovided by HGNC Primary source HGNC:HGNC:3266 See related Ensembl:ENSG00000125977 MIM:603908; AllianceGenome:HGNC:3266 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta Summary Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in placenta (RPKM 24.2), thyroid (RPKM 22.6) and 25 other tissues See more Orthologs mouse all
EIF2S2P1, Official Symbol EIF2S2P1provided by HGNC Official Full Name eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 1provided by HGNC Primary source HGNC:HGNC:20009 See related AllianceGenome:HGNC:20009 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF2S2P
EIF2S3, Official Symbol EIF2S3provided by HGNC Official Full Name eukaryotic translation initiation factor 2 subunit gammaprovided by HGNC Primary source HGNC:HGNC:3267 See related Ensembl:ENSG00000130741 MIM:300161; AllianceGenome:HGNC:3267 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF2; EIF2G; MEHMO; MRXSBRK; eIF-2gA; EIF2gamma Summary The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010] Expression Ubiquitous expression in ovary (RPKM 61.4), lymph node (RPKM 53.4) and 25 other tissues See more Orthologs mouse all
EIF2S3B, Official Symbol EIF2S3Bprovided by HGNC Official Full Name eukaryotic translation initiation factor 2 subunit gamma Bprovided by HGNC Primary source HGNC:HGNC:43863 See related Ensembl:ENSG00000180574 AllianceGenome:HGNC:43863 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as eIF2gA; EIF2S3L; eIF-2gA Summary Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to be part of eukaryotic translation initiation factor 2 complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
EIF3A, Official Symbol EIF3Aprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Aprovided by HGNC Primary source HGNC:HGNC:3271 See related Ensembl:ENSG00000107581 MIM:602039; AllianceGenome:HGNC:3271 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta Summary Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues See more Orthologs mouse all
EIF3B, Official Symbol EIF3Bprovided by HGNC Official Full Name eukaryotic translation initiation factor 3 subunit Bprovided by HGNC Primary source HGNC:HGNC:3280 See related Ensembl:ENSG00000106263 MIM:603917; AllianceGenome:HGNC:3280 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116 Summary Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues See more Orthologs mouse all