psui3905/ncbi_genes_summary huggingface dataset:
RANBP6, Official Symbol RANBP6provided by HGNC Official Full Name RAN binding protein 6provided by HGNC Primary source HGNC:HGNC:9851 See related Ensembl:ENSG00000137040 AllianceGenome:HGNC:9851 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 13.1), brain (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
RANBP9, Official Symbol RANBP9provided by HGNC Official Full Name RAN binding protein 9provided by HGNC Primary source HGNC:HGNC:13727 See related Ensembl:ENSG00000010017 MIM:603854; AllianceGenome:HGNC:13727 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPM-L; BPM90; RANBPM; RanBP7 Summary This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 72.2), esophagus (RPKM 38.9) and 23 other tissues See more Orthologs mouse all
RANGAP1, Official Symbol RANGAP1provided by HGNC Official Full Name Ran GTPase activating protein 1provided by HGNC Primary source HGNC:HGNC:9854 See related Ensembl:ENSG00000100401 MIM:602362; AllianceGenome:HGNC:9854 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SD; Fug1; RANGAP Summary This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Broad expression in testis (RPKM 19.7), skin (RPKM 13.7) and 25 other tissues See more Orthologs mouse all
RANGRF, Official Symbol RANGRFprovided by HGNC Official Full Name RAN guanine nucleotide release factorprovided by HGNC Primary source HGNC:HGNC:17679 See related Ensembl:ENSG00000108961 MIM:607954; AllianceGenome:HGNC:17679 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MOG1; HSPC165; HSPC236; RANGNRF Summary This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] Expression Broad expression in testis (RPKM 13.3), endometrium (RPKM 7.1) and 24 other tissues See more Orthologs mouse all
RANP2, Official Symbol RANP2provided by HGNC Official Full Name RAN pseudogene 2provided by HGNC Primary source HGNC:HGNC:39857 See related AllianceGenome:HGNC:39857 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RANP7, Official Symbol RANP7provided by HGNC Official Full Name RAN pseudogene 7provided by HGNC Primary source HGNC:HGNC:39862 See related AllianceGenome:HGNC:39862 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RANP8, Official Symbol RANP8provided by HGNC Official Full Name RAN pseudogene 8provided by HGNC Primary source HGNC:HGNC:39863 See related AllianceGenome:HGNC:39863 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RANP9, Official Symbol RANP9provided by HGNC Official Full Name RAN pseudogene 9provided by HGNC Primary source HGNC:HGNC:39864 See related Ensembl:ENSG00000253393 AllianceGenome:HGNC:39864 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RAP1A, Official Symbol RAP1Aprovided by HGNC Official Full Name RAP1A, member of RAS oncogene familyprovided by HGNC Primary source HGNC:HGNC:9855 See related Ensembl:ENSG00000116473 MIM:179520; AllianceGenome:HGNC:9855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAP1; C21KG; G-22K; KREV1; KREV-1; SMGP21 Summary This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in appendix (RPKM 12.2), esophagus (RPKM 11.3) and 25 other tissues See more Orthologs mouse all
RAP1B, Official Symbol RAP1Bprovided by HGNC Official Full Name RAP1B, member of RAS oncogene familyprovided by HGNC Primary source HGNC:HGNC:9857 See related Ensembl:ENSG00000127314 MIM:179530; AllianceGenome:HGNC:9857 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as K-REV; RAL1B Summary This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in lymph node (RPKM 83.8), appendix (RPKM 79.8) and 25 other tissues See more Orthologs mouse all
RAP1BP3, Official Symbol RAP1BP3provided by HGNC Official Full Name RAP1B pseudogene 3provided by HGNC Primary source HGNC:HGNC:49782 See related AllianceGenome:HGNC:49782 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RAP1GAP, Official Symbol RAP1GAPprovided by HGNC Official Full Name RAP1 GTPase activating proteinprovided by HGNC Primary source HGNC:HGNC:9858 See related Ensembl:ENSG00000076864 MIM:600278; AllianceGenome:HGNC:9858 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII Summary This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011] Expression Biased expression in thyroid (RPKM 75.3), brain (RPKM 38.1) and 11 other tissues See more Orthologs mouse all
RAP1GAP2, Official Symbol RAP1GAP2provided by HGNC Official Full Name RAP1 GTPase activating protein 2provided by HGNC Primary source HGNC:HGNC:29176 See related Ensembl:ENSG00000132359 MIM:618714; AllianceGenome:HGNC:29176 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GARNL4; RAP1GA3 Summary This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in brain (RPKM 11.5), bone marrow (RPKM 10.7) and 24 other tissues See more Orthologs mouse all
RAP1GDS1, Official Symbol RAP1GDS1provided by HGNC Official Full Name Rap1 GTPase-GDP dissociation stimulator 1provided by HGNC Primary source HGNC:HGNC:9859 See related Ensembl:ENSG00000138698 MIM:179502; AllianceGenome:HGNC:9859 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GDS1; SmgGDS Summary The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010] Expression Ubiquitous expression in brain (RPKM 27.0), testis (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
RAP2A, Official Symbol RAP2Aprovided by HGNC Official Full Name RAP2A, member of RAS oncogene familyprovided by HGNC Primary source HGNC:HGNC:9861 See related Ensembl:ENSG00000125249 MIM:179540; AllianceGenome:HGNC:9861 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KREV; RAP2; K-REV; RbBP-30 Summary Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including actin cytoskeleton reorganization; microvillus assembly; and positive regulation of protein autophosphorylation. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 41.0), placenta (RPKM 14.5) and 23 other tissues See more Orthologs mouse all
RAP2B, Official Symbol RAP2Bprovided by HGNC Official Full Name RAP2B, member of RAS oncogene familyprovided by HGNC Primary source HGNC:HGNC:9862 See related Ensembl:ENSG00000181467 MIM:179541; AllianceGenome:HGNC:9862 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008] Orthologs mouse all
RAP2C, Official Symbol RAP2Cprovided by HGNC Official Full Name RAP2C, member of RAS oncogene familyprovided by HGNC Primary source HGNC:HGNC:21165 See related Ensembl:ENSG00000123728 MIM:301016; AllianceGenome:HGNC:21165 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012] Expression Ubiquitous expression in endometrium (RPKM 31.6), bone marrow (RPKM 18.9) and 24 other tissues See more Orthologs mouse all
RAP2C-AS1, Official Symbol RAP2C-AS1provided by HGNC Official Full Name RAP2C antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40957 See related Ensembl:ENSG00000232160 AllianceGenome:HGNC:40957 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in endometrium (RPKM 2.1), thyroid (RPKM 1.0) and 25 other tissues See more
RAP2CP1, Official Symbol RAP2CP1provided by HGNC Official Full Name RAP2C pseudogene 1provided by HGNC Primary source HGNC:HGNC:49146 See related Ensembl:ENSG00000270938 AllianceGenome:HGNC:49146 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RAPGEF1, Official Symbol RAPGEF1provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 1provided by HGNC Primary source HGNC:HGNC:4568 See related Ensembl:ENSG00000107263 MIM:600303; AllianceGenome:HGNC:4568 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C3G; GRF2 Summary This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 13.7), lymph node (RPKM 12.3) and 25 other tissues See more Orthologs mouse all
RAPGEF2, Official Symbol RAPGEF2provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 2provided by HGNC Primary source HGNC:HGNC:16854 See related Ensembl:ENSG00000109756 MIM:609530; AllianceGenome:HGNC:16854 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAGEF; RA-GEF; NRAPGEP; PDZGEF1; Rap-GEP; CNrasGEF; PDZ-GEF1; RA-GEF-1; nRap GEP Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in brain (RPKM 13.6), bone marrow (RPKM 11.0) and 25 other tissues See more Orthologs mouse all
RAPGEF3, Official Symbol RAPGEF3provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 3provided by HGNC Primary source HGNC:HGNC:16629 See related Ensembl:ENSG00000079337 MIM:606057; AllianceGenome:HGNC:16629 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI Summary Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including positive regulation of protein modification process; regulation of actin cytoskeleton organization; and regulation of syncytium formation by plasma membrane fusion. Located in filopodium; lamellipodium; and microvillus. Colocalizes with cortical actin cytoskeleton and plasma membrane. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 15.0), thyroid (RPKM 13.2) and 22 other tissues See more Orthologs mouse all
RAPGEF4, Official Symbol RAPGEF4provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 4provided by HGNC Primary source HGNC:HGNC:16626 See related Ensembl:ENSG00000091428 MIM:606058; AllianceGenome:HGNC:16626 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII Summary Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 37.0), adrenal (RPKM 17.3) and 12 other tissues See more Orthologs mouse all
RAPGEF4-AS1, Official Symbol RAPGEF4-AS1provided by HGNC Official Full Name RAPGEF4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:28081 See related Ensembl:ENSG00000228016 AllianceGenome:HGNC:28081 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
RAPGEF5, Official Symbol RAPGEF5provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 5provided by HGNC Primary source HGNC:HGNC:16862 See related Ensembl:ENSG00000136237 MIM:609527; AllianceGenome:HGNC:16862 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GFR; MRGEF; REPAC; MR-GEF Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] Expression Broad expression in brain (RPKM 18.5), spleen (RPKM 13.5) and 23 other tissues See more Orthologs mouse all
RAPGEF6, Official Symbol RAPGEF6provided by HGNC Official Full Name Rap guanine nucleotide exchange factor 6provided by HGNC Primary source HGNC:HGNC:20655 See related Ensembl:ENSG00000158987 MIM:610499; AllianceGenome:HGNC:20655 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAGEF2; PDZGEF2; KIA001LB; PDZ-GEF2; RA-GEF-2 Summary Enables several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Involved in microvillus assembly; positive regulation of GTPase activity; and protein localization to plasma membrane. Located in several cellular components, including apical plasma membrane; centrosome; and endocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 9.8), appendix (RPKM 6.5) and 24 other tissues See more Orthologs mouse all
RAPGEFL1, Official Symbol RAPGEFL1provided by HGNC Official Full Name Rap guanine nucleotide exchange factor like 1provided by HGNC Primary source HGNC:HGNC:17428 See related Ensembl:ENSG00000108352 AllianceGenome:HGNC:17428 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Link-GEFII Summary Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and nervous system development. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 52.1), esophagus (RPKM 22.9) and 7 other tissues See more Orthologs mouse all
RAPH1, Official Symbol RAPH1provided by HGNC Official Full Name Ras association (RalGDS/AF-6) and pleckstrin homology domains 1provided by HGNC Primary source HGNC:HGNC:14436 See related Ensembl:ENSG00000173166 MIM:609035; AllianceGenome:HGNC:14436 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPD; RMO1; PREL2; PREL-2; ALS2CR9; ALS2CR18; RalGDS/AF-6 Summary This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in thyroid (RPKM 14.2), liver (RPKM 12.2) and 23 other tissues See more Orthologs mouse all
RAPSN, Official Symbol RAPSNprovided by HGNC Official Full Name receptor associated protein of the synapseprovided by HGNC Primary source HGNC:HGNC:9863 See related Ensembl:ENSG00000165917 MIM:601592; AllianceGenome:HGNC:9863 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FADS; CMS11; CMS4C; FADS2; RAPSYN; RNF205 Summary This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011] Expression Biased expression in placenta (RPKM 1.3), prostate (RPKM 0.9) and 7 other tissues See more Orthologs mouse all
RARA, Official Symbol RARAprovided by HGNC Official Full Name retinoic acid receptor alphaprovided by HGNC Primary source HGNC:HGNC:9864 See related Ensembl:ENSG00000131759 MIM:180240; AllianceGenome:HGNC:9864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAR; NR1B1; RARalpha Summary This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010] Expression Ubiquitous expression in lung (RPKM 10.4), spleen (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
RARA-AS1, Official Symbol RARA-AS1provided by HGNC Official Full Name RARA antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49577 See related Ensembl:ENSG00000265666 AllianceGenome:HGNC:49577 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in small intestine (RPKM 2.1), colon (RPKM 1.9) and 25 other tissues See more
RARB, Official Symbol RARBprovided by HGNC Official Full Name retinoic acid receptor betaprovided by HGNC Primary source HGNC:HGNC:9865 See related Ensembl:ENSG00000077092 MIM:180220; AllianceGenome:HGNC:9865 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HAP; RRB2; NR1B2; MCOPS12; RARbeta; RARbeta1 Summary This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in placenta (RPKM 7.0), urinary bladder (RPKM 5.7) and 22 other tissues See more Orthologs mouse all
RARG, Official Symbol RARGprovided by HGNC Official Full Name retinoic acid receptor gammaprovided by HGNC Primary source HGNC:HGNC:9866 See related Ensembl:ENSG00000172819 MIM:180190; AllianceGenome:HGNC:9866 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RARC; NR1B3; RARgamma Summary This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Broad expression in skin (RPKM 47.1), esophagus (RPKM 32.0) and 18 other tissues See more Orthologs mouse all
RARRES1, Official Symbol RARRES1provided by HGNC Official Full Name retinoic acid receptor responder 1provided by HGNC Primary source HGNC:HGNC:9867 See related Ensembl:ENSG00000118849 MIM:605090; AllianceGenome:HGNC:9867 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LXNL; TIG1; PERG-1 Summary This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 33.7), urinary bladder (RPKM 25.5) and 17 other tissues See more Orthologs mouse all
RARRES2, Official Symbol RARRES2provided by HGNC Official Full Name retinoic acid receptor responder 2provided by HGNC Primary source HGNC:HGNC:9868 See related Ensembl:ENSG00000106538 MIM:601973; AllianceGenome:HGNC:9868 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIG2; HP10433 Summary This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014] Expression Broad expression in adrenal (RPKM 464.3), fat (RPKM 307.4) and 14 other tissues See more Orthologs mouse all
RARRES2P10, Official Symbol RARRES2P10provided by HGNC Official Full Name retinoic acid receptor responder 2 pseudogene 10provided by HGNC Primary source HGNC:HGNC:51742 See related Ensembl:ENSG00000260153 AllianceGenome:HGNC:51742 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RARRES2P11, Official Symbol RARRES2P11provided by HGNC Official Full Name retinoic acid receptor responder 2 pseudogene 11provided by HGNC Primary source HGNC:HGNC:51743 See related AllianceGenome:HGNC:51743 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RARRES2P2, Official Symbol RARRES2P2provided by HGNC Official Full Name retinoic acid receptor responder 2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:48701 See related AllianceGenome:HGNC:48701 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RARRES2P3, Official Symbol RARRES2P3provided by HGNC Official Full Name retinoic acid receptor responder 2 pseudogene 3provided by HGNC Primary source HGNC:HGNC:48702 See related Ensembl:ENSG00000231913 AllianceGenome:HGNC:48702 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RARRES2P5, Official Symbol RARRES2P5provided by HGNC Official Full Name retinoic acid receptor responder 2 pseudogene 5provided by HGNC Primary source HGNC:HGNC:48704 See related Ensembl:ENSG00000260967 AllianceGenome:HGNC:48704 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RARRES2P6, Official Symbol RARRES2P6provided by HGNC Official Full Name retinoic acid receptor responder 2 pseudogene 6provided by HGNC Primary source HGNC:HGNC:48705 See related Ensembl:ENSG00000261010 AllianceGenome:HGNC:48705 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RARS1, Official Symbol RARS1provided by HGNC Official Full Name arginyl-tRNA synthetase 1provided by HGNC Primary source HGNC:HGNC:9870 See related Ensembl:ENSG00000113643 MIM:107820; AllianceGenome:HGNC:9870 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLD9; RARS; ArgRS; DALRD1 Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 28.0), small intestine (RPKM 25.9) and 25 other tissues See more Orthologs mouse all
RARS2, Official Symbol RARS2provided by HGNC Official Full Name arginyl-tRNA synthetase 2, mitochondrialprovided by HGNC Primary source HGNC:HGNC:21406 See related Ensembl:ENSG00000146282 MIM:611524; AllianceGenome:HGNC:21406 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCH6; ArgRS; RARSL; DALRD2; PRO1992 Summary This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in adrenal (RPKM 9.8), testis (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
RASA1, Official Symbol RASA1provided by HGNC Official Full Name RAS p21 protein activator 1provided by HGNC Primary source HGNC:HGNC:9871 See related Ensembl:ENSG00000145715 MIM:139150; AllianceGenome:HGNC:9871 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAP; PKWS; RASA; p120; CMAVM; CM-AVM; CMAVM1; RASGAP; p120GAP; p120RASGAP Summary The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012] Expression Broad expression in placenta (RPKM 37.4), testis (RPKM 12.6) and 24 other tissues See more Orthologs mouse all
RASA2, Official Symbol RASA2provided by HGNC Official Full Name RAS p21 protein activator 2provided by HGNC Primary source HGNC:HGNC:9872 See related Ensembl:ENSG00000155903 MIM:601589; AllianceGenome:HGNC:9872 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAP1M Summary The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in lymph node (RPKM 9.4), appendix (RPKM 7.9) and 24 other tissues See more Orthologs mouse all
RASA3, Official Symbol RASA3provided by HGNC Official Full Name RAS p21 protein activator 3provided by HGNC Primary source HGNC:HGNC:20331 See related Ensembl:ENSG00000185989 MIM:605182; AllianceGenome:HGNC:20331 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAPIII; GAP1IP4BP Summary This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in fat (RPKM 14.2), lymph node (RPKM 12.1) and 25 other tissues See more Orthologs mouse all
RASA3-IT1, Official Symbol RASA3-IT1provided by HGNC Official Full Name RASA3 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:39938 See related AllianceGenome:HGNC:39938 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RASA4, Official Symbol RASA4provided by HGNC Official Full Name RAS p21 protein activator 4provided by HGNC Primary source HGNC:HGNC:23181 See related Ensembl:ENSG00000105808 MIM:607943; AllianceGenome:HGNC:23181 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAPL; CAPRI Summary This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 14.7), spleen (RPKM 11.8) and 24 other tissues See more Orthologs mouse all
RASA4B, Official Symbol RASA4Bprovided by HGNC Official Full Name RAS p21 protein activator 4Bprovided by HGNC Primary source HGNC:HGNC:35202 See related Ensembl:ENSG00000170667 AllianceGenome:HGNC:35202 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 22.0), brain (RPKM 17.5) and 24 other tissues See more Orthologs all
RASAL1, Official Symbol RASAL1provided by HGNC Official Full Name RAS protein activator like 1provided by HGNC Primary source HGNC:HGNC:9873 See related Ensembl:ENSG00000111344 MIM:604118; AllianceGenome:HGNC:9873 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RASAL Summary The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010] Expression Broad expression in brain (RPKM 6.0), lymph node (RPKM 5.1) and 18 other tissues See more Orthologs mouse all
RASAL2, Official Symbol RASAL2provided by HGNC Official Full Name RAS protein activator like 2provided by HGNC Primary source HGNC:HGNC:9874 See related Ensembl:ENSG00000075391 MIM:606136; AllianceGenome:HGNC:9874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NGAP Summary This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 4.0), fat (RPKM 3.6) and 24 other tissues See more Orthologs mouse all
RASAL2-AS1, Official Symbol RASAL2-AS1provided by HGNC Official Full Name RASAL2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44170 See related Ensembl:ENSG00000224687 AllianceGenome:HGNC:44170 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
RASAL3, Official Symbol RASAL3provided by HGNC Official Full Name RAS protein activator like 3provided by HGNC Primary source HGNC:HGNC:26129 See related Ensembl:ENSG00000105122 MIM:616561; AllianceGenome:HGNC:26129 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017] Expression Broad expression in lymph node (RPKM 18.0), spleen (RPKM 15.7) and 14 other tissues See more Orthologs mouse all