psui3905/ncbi_genes_summary huggingface dataset:
RNY3P15, Official Symbol RNY3P15provided by HGNC Official Full Name RNY3 pseudogene 15provided by HGNC Primary source HGNC:HGNC:50890 See related Ensembl:ENSG00000252106 AllianceGenome:HGNC:50890 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY3P16, Official Symbol RNY3P16provided by HGNC Official Full Name RNY3 pseudogene 16provided by HGNC Primary source HGNC:HGNC:50891 See related Ensembl:ENSG00000252147 AllianceGenome:HGNC:50891 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY3P2, Official Symbol RNY3P2provided by HGNC Official Full Name RNY3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:42486 See related Ensembl:ENSG00000199788 AllianceGenome:HGNC:42486 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY3P3, Official Symbol RNY3P3provided by HGNC Official Full Name RNY3 pseudogene 3provided by HGNC Primary source HGNC:HGNC:42487 See related Ensembl:ENSG00000200686 AllianceGenome:HGNC:42487 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY3P4, Official Symbol RNY3P4provided by HGNC Official Full Name RNY3 pseudogene 4provided by HGNC Primary source HGNC:HGNC:42488 See related Ensembl:ENSG00000207157 AllianceGenome:HGNC:42488 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY3P7, Official Symbol RNY3P7provided by HGNC Official Full Name RNY3 pseudogene 7provided by HGNC Primary source HGNC:HGNC:42491 See related Ensembl:ENSG00000206800 AllianceGenome:HGNC:42491 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY3P9, Official Symbol RNY3P9provided by HGNC Official Full Name RNY3 pseudogene 9provided by HGNC Primary source HGNC:HGNC:42493 See related Ensembl:ENSG00000207458 AllianceGenome:HGNC:42493 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4, Official Symbol RNY4provided by HGNC Official Full Name RNA, Ro60-associated Y4provided by HGNC Primary source HGNC:HGNC:10244 See related Ensembl:ENSG00000252316 MIM:601823; AllianceGenome:HGNC:10244 Gene type ncRNA RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Y4; HY4
RNY4P10, Official Symbol RNY4P10provided by HGNC Official Full Name RNY4 pseudogene 10provided by HGNC Primary source HGNC:HGNC:34060 See related Ensembl:ENSG00000202441 AllianceGenome:HGNC:34060 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P14, Official Symbol RNY4P14provided by HGNC Official Full Name RNY4 pseudogene 14provided by HGNC Primary source HGNC:HGNC:34064 See related Ensembl:ENSG00000200526 AllianceGenome:HGNC:34064 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P16, Official Symbol RNY4P16provided by HGNC Official Full Name RNY4 pseudogene 16provided by HGNC Primary source HGNC:HGNC:34066 See related Ensembl:ENSG00000201638 AllianceGenome:HGNC:34066 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P17, Official Symbol RNY4P17provided by HGNC Official Full Name RNY4 pseudogene 17provided by HGNC Primary source HGNC:HGNC:34067 See related Ensembl:ENSG00000201818 AllianceGenome:HGNC:34067 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P18, Official Symbol RNY4P18provided by HGNC Official Full Name RNY4 pseudogene 18provided by HGNC Primary source HGNC:HGNC:34068 See related Ensembl:ENSG00000212409 AllianceGenome:HGNC:34068 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P19, Official Symbol RNY4P19provided by HGNC Official Full Name RNY4 pseudogene 19provided by HGNC Primary source HGNC:HGNC:34069 See related Ensembl:ENSG00000199400 AllianceGenome:HGNC:34069 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P20, Official Symbol RNY4P20provided by HGNC Official Full Name RNY4 pseudogene 20provided by HGNC Primary source HGNC:HGNC:34070 See related Ensembl:ENSG00000252487 AllianceGenome:HGNC:34070 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P23, Official Symbol RNY4P23provided by HGNC Official Full Name RNY4 pseudogene 23provided by HGNC Primary source HGNC:HGNC:42473 See related Ensembl:ENSG00000201377 AllianceGenome:HGNC:42473 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P24, Official Symbol RNY4P24provided by HGNC Official Full Name RNY4 pseudogene 24provided by HGNC Primary source HGNC:HGNC:42474 See related Ensembl:ENSG00000199605 AllianceGenome:HGNC:42474 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P25, Official Symbol RNY4P25provided by HGNC Official Full Name RNY4 pseudogene 25provided by HGNC Primary source HGNC:HGNC:42475 See related Ensembl:ENSG00000238711 AllianceGenome:HGNC:42475 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P27, Official Symbol RNY4P27provided by HGNC Official Full Name RNY4 pseudogene 27provided by HGNC Primary source HGNC:HGNC:42495 See related Ensembl:ENSG00000200211 AllianceGenome:HGNC:42495 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P28, Official Symbol RNY4P28provided by HGNC Official Full Name RNY4 pseudogene 28provided by HGNC Primary source HGNC:HGNC:42496 See related Ensembl:ENSG00000202151 AllianceGenome:HGNC:42496 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P29, Official Symbol RNY4P29provided by HGNC Official Full Name RNY4 pseudogene 29provided by HGNC Primary source HGNC:HGNC:42497 See related Ensembl:ENSG00000222733 AllianceGenome:HGNC:42497 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P3, Official Symbol RNY4P3provided by HGNC Official Full Name RNY4 pseudogene 3provided by HGNC Primary source HGNC:HGNC:10247 See related Ensembl:ENSG00000202124 AllianceGenome:HGNC:10247 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hY4.F2
RNY4P30, Official Symbol RNY4P30provided by HGNC Official Full Name RNY4 pseudogene 30provided by HGNC Primary source HGNC:HGNC:42498 See related Ensembl:ENSG00000222148 AllianceGenome:HGNC:42498 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P34, Official Symbol RNY4P34provided by HGNC Official Full Name RNY4 pseudogene 34provided by HGNC Primary source HGNC:HGNC:50882 See related Ensembl:ENSG00000201649 AllianceGenome:HGNC:50882 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P36, Official Symbol RNY4P36provided by HGNC Official Full Name RNY4 pseudogene 36provided by HGNC Primary source HGNC:HGNC:50884 See related Ensembl:ENSG00000212418 AllianceGenome:HGNC:50884 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P37, Official Symbol RNY4P37provided by HGNC Official Full Name RNY4 pseudogene 37provided by HGNC Primary source HGNC:HGNC:50885 See related Ensembl:ENSG00000252034 AllianceGenome:HGNC:50885 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P6, Official Symbol RNY4P6provided by HGNC Official Full Name RNY4 pseudogene 6provided by HGNC Primary source HGNC:HGNC:34055 See related Ensembl:ENSG00000200537 AllianceGenome:HGNC:34055 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P7, Official Symbol RNY4P7provided by HGNC Official Full Name RNY4 pseudogene 7provided by HGNC Primary source HGNC:HGNC:34056 See related Ensembl:ENSG00000201470 AllianceGenome:HGNC:34056 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY4P9, Official Symbol RNY4P9provided by HGNC Official Full Name RNY4 pseudogene 9provided by HGNC Primary source HGNC:HGNC:34058 See related Ensembl:ENSG00000200064 AllianceGenome:HGNC:34058 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RNY5, Official Symbol RNY5provided by HGNC Official Full Name RNA, Ro60-associated Y5provided by HGNC Primary source HGNC:HGNC:10248 See related MIM:601824; AllianceGenome:HGNC:10248 Gene type ncRNA RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Y5; hY5 Annotation information Note: GeneID 6090 was incorrectly annotated on chromosome 12 on NCBI's Build 37.3. This gene is located at NT_007914.15:9234203 9234286 (+) in NCBI's build 37.3. [17 Jun 2014]
RO60, Official Symbol RO60provided by HGNC Official Full Name Ro60, Y RNA binding proteinprovided by HGNC Primary source HGNC:HGNC:11313 See related Ensembl:ENSG00000116747 MIM:600063; AllianceGenome:HGNC:11313 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SSA2; RORNP; TROVE2 Summary Enables RNA binding activity. Involved in cellular response to interferon-alpha and regulation of gene expression. Located in cytosol and nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues See more Orthologs mouse all
ROBO1, Official Symbol ROBO1provided by HGNC Official Full Name roundabout guidance receptor 1provided by HGNC Primary source HGNC:HGNC:10249 See related Ensembl:ENSG00000169855 MIM:602430; AllianceGenome:HGNC:10249 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NORS; NYS8; SAX3; CPHD8; DUTT1 Summary Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Expression Ubiquitous expression in brain (RPKM 11.9), skin (RPKM 9.4) and 23 other tissues See more Orthologs mouse all
ROBO2, Official Symbol ROBO2provided by HGNC Official Full Name roundabout guidance receptor 2provided by HGNC Primary source HGNC:HGNC:10250 See related Ensembl:ENSG00000185008 MIM:602431; AllianceGenome:HGNC:10250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAX3 Summary The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Broad expression in brain (RPKM 5.1), lung (RPKM 2.8) and 14 other tissues See more Orthologs mouse all
ROBO2P1, Official Symbol ROBO2P1provided by HGNC Official Full Name roundabout guidance receptor 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44386 See related Ensembl:ENSG00000229478 AllianceGenome:HGNC:44386 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ROBO3, Official Symbol ROBO3provided by HGNC Official Full Name roundabout guidance receptor 3provided by HGNC Primary source HGNC:HGNC:13433 See related Ensembl:ENSG00000154134 MIM:608630; AllianceGenome:HGNC:13433 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HGPS; RIG1; HGPPS; RBIG1; HGPPS1 Summary This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019] Expression Ubiquitous expression in ovary (RPKM 7.2), spleen (RPKM 3.0) and 21 other tissues See more Orthologs mouse all
ROBO4, Official Symbol ROBO4provided by HGNC Official Full Name roundabout guidance receptor 4provided by HGNC Primary source HGNC:HGNC:17985 See related Ensembl:ENSG00000154133 MIM:607528; AllianceGenome:HGNC:17985 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRB; AOVD3; ECSM4 Summary Predicted to enable cell-cell adhesion mediator activity. Involved in angiogenesis and establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 35.9), spleen (RPKM 32.4) and 17 other tissues See more Orthologs mouse all
ROCK1, Official Symbol ROCK1provided by HGNC Official Full Name Rho associated coiled-coil containing protein kinase 1provided by HGNC Primary source HGNC:HGNC:10251 See related Ensembl:ENSG00000067900 MIM:601702; AllianceGenome:HGNC:10251 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ROCK-I; P160ROCK Summary This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015] Expression Ubiquitous expression in bone marrow (RPKM 22.1), fat (RPKM 16.6) and 25 other tissues See more Orthologs mouse all
ROCK2, Official Symbol ROCK2provided by HGNC Official Full Name Rho associated coiled-coil containing protein kinase 2provided by HGNC Primary source HGNC:HGNC:10252 See related Ensembl:ENSG00000134318 MIM:604002; AllianceGenome:HGNC:10252 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ROCK-II Summary The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 15.2), colon (RPKM 13.4) and 25 other tissues See more Orthologs mouse all
ROGDI, Official Symbol ROGDIprovided by HGNC Official Full Name rogdi atypical leucine zipperprovided by HGNC Primary source HGNC:HGNC:29478 See related Ensembl:ENSG00000067836 MIM:614574; AllianceGenome:HGNC:29478 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KTZS; RAV2; ROGD1 Summary Involved in brain development; neurogenesis; and odontogenesis of dentin-containing tooth. Located in nuclear envelope. Implicated in Kohlschutter-Tonz syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 26.0), bone marrow (RPKM 23.4) and 25 other tissues See more Orthologs mouse all
ROM1, Official Symbol ROM1provided by HGNC Official Full Name retinal outer segment membrane protein 1provided by HGNC Primary source HGNC:HGNC:10254 See related Ensembl:ENSG00000149489 MIM:180721; AllianceGenome:HGNC:10254 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ROM; RP7; ROSP1; TSPAN23 Summary This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 5.2), ovary (RPKM 2.2) and 23 other tissues See more Orthologs mouse all
ROMO1, Official Symbol ROMO1provided by HGNC Official Full Name reactive oxygen species modulator 1provided by HGNC Primary source HGNC:HGNC:16185 See related Ensembl:ENSG00000125995 MIM:618894; AllianceGenome:HGNC:16185 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTGM; MTGMP; C20orf52; bA353C18.2 Summary The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014] Expression Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues See more Orthologs mouse all
ROPN1, Official Symbol ROPN1provided by HGNC Official Full Name rhophilin associated tail protein 1provided by HGNC Primary source HGNC:HGNC:17692 See related Ensembl:ENSG00000065371 MIM:611757; AllianceGenome:HGNC:17692 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT91; ODF6; ROPN1A; RHPNAP1; ropporin Summary The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015] Expression Restricted expression toward testis (RPKM 42.1) See more Orthologs mouse all
ROPN1B, Official Symbol ROPN1Bprovided by HGNC Official Full Name rhophilin associated tail protein 1Bprovided by HGNC Primary source HGNC:HGNC:31927 See related Ensembl:ENSG00000114547 AllianceGenome:HGNC:31927 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables protein heterodimerization activity. Predicted to be involved in several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Located in cytoplasm and motile cilium. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 113.4) See more Orthologs all
ROPN1L, Official Symbol ROPN1Lprovided by HGNC Official Full Name rhophilin associated tail protein 1 likeprovided by HGNC Primary source HGNC:HGNC:24060 See related Ensembl:ENSG00000145491 MIM:611756; AllianceGenome:HGNC:24060 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASP; RSPH11 Summary This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014] Expression Restricted expression toward testis (RPKM 83.7) See more Orthologs mouse all
ROPN1L-AS1, Official Symbol ROPN1L-AS1provided by HGNC Official Full Name ROPN1L antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39984 See related AllianceGenome:HGNC:39984 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 3.3) See more
ROR1, Official Symbol ROR1provided by HGNC Official Full Name receptor tyrosine kinase like orphan receptor 1provided by HGNC Primary source HGNC:HGNC:10256 See related Ensembl:ENSG00000185483 MIM:602336; AllianceGenome:HGNC:10256 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTRKR1; dJ537F10.1 Summary This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] Expression Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues See more Orthologs mouse all
ROR1-AS1, Official Symbol ROR1-AS1provided by HGNC Official Full Name ROR1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40508 See related Ensembl:ENSG00000223949 AllianceGenome:HGNC:40508 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.4) See more
ROR2, Official Symbol ROR2provided by HGNC Official Full Name receptor tyrosine kinase like orphan receptor 2provided by HGNC Primary source HGNC:HGNC:10257 See related Ensembl:ENSG00000169071 MIM:602337; AllianceGenome:HGNC:10257 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDB; BDB1; NTRKR2 Summary The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 5.4), gall bladder (RPKM 3.7) and 18 other tissues See more Orthologs mouse all
RORA, Official Symbol RORAprovided by HGNC Official Full Name RAR related orphan receptor Aprovided by HGNC Primary source HGNC:HGNC:10258 See related Ensembl:ENSG00000069667 MIM:600825; AllianceGenome:HGNC:10258 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ROR1; ROR2; ROR3; RZRA; NR1F1; RORa1; IDDECA; RORalpha; RZR-ALPHA Summary The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014] Expression Broad expression in skin (RPKM 15.9), adrenal (RPKM 10.1) and 21 other tissues See more Orthologs mouse all
RORA-AS1, Official Symbol RORA-AS1provided by HGNC Official Full Name RORA antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51410 See related Ensembl:ENSG00000245534 AllianceGenome:HGNC:51410 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 2.3), skin (RPKM 2.2) and 22 other tissues See more
RORA-AS2, Official Symbol RORA-AS2provided by HGNC Official Full Name RORA antisense RNA 2provided by HGNC Primary source HGNC:HGNC:51411 See related Ensembl:ENSG00000259482 AllianceGenome:HGNC:51411 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 4.2) See more
RORB, Official Symbol RORBprovided by HGNC Official Full Name RAR related orphan receptor Bprovided by HGNC Primary source HGNC:HGNC:10259 See related Ensembl:ENSG00000198963 MIM:601972; AllianceGenome:HGNC:10259 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RZRB; EIG15; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1 Summary The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014] Expression Biased expression in brain (RPKM 5.4), endometrium (RPKM 3.4) and 9 other tissues See more Orthologs mouse all
RORC, Official Symbol RORCprovided by HGNC Official Full Name RAR related orphan receptor Cprovided by HGNC Primary source HGNC:HGNC:10260 See related Ensembl:ENSG00000143365 MIM:602943; AllianceGenome:HGNC:10260 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA Summary The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 16.0), thyroid (RPKM 15.9) and 18 other tissues See more Orthologs mouse all
ROS1, Official Symbol ROS1provided by HGNC Official Full Name ROS proto-oncogene 1, receptor tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:10261 See related Ensembl:ENSG00000047936 MIM:165020; AllianceGenome:HGNC:10261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ROS; MCF3; c-ros-1 Summary This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008] Expression Restricted expression toward lung (RPKM 10.3) See more Orthologs mouse all
RP1, Official Symbol RP1provided by HGNC Official Full Name RP1 axonemal microtubule associatedprovided by HGNC Primary source HGNC:HGNC:10263 See related Ensembl:ENSG00000104237 MIM:603937; AllianceGenome:HGNC:10263 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ORP1; DCDC4A Summary This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
RP1L1, Official Symbol RP1L1provided by HGNC Official Full Name RP1 like 1provided by HGNC Primary source HGNC:HGNC:15946 See related Ensembl:ENSG00000183638 MIM:608581; AllianceGenome:HGNC:15946 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OCMD; RP88; DCDC4B Summary This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, and two C-terminal large repetitive regions, both of which contain a high percentage of glutamine and glutamic acid residues. This protein is a retinal-specific protein. Its exact length varies among individuals due to the presence of a 16aa repeat in the first C-terminal repetitive region. The 16aa repeat is encoded by the highly polymorphic 48-bp repeat, and 1-6 copies of the 16aa repeat have been identified in normal individuals. The current reference sequence shown here has a single copy of the 16aa repeat. This protein and the RP1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Mutations in this gene cause occult macular dystrophy (OMD). [provided by RefSeq, Sep 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
RP2, Official Symbol RP2provided by HGNC Official Full Name RP2 activator of ARL3 GTPaseprovided by HGNC Primary source HGNC:HGNC:10274 See related Ensembl:ENSG00000102218 MIM:300757; AllianceGenome:HGNC:10274 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3 Summary The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 18.5), placenta (RPKM 13.6) and 24 other tissues See more Orthologs mouse all
RP9, Official Symbol RP9provided by HGNC Official Full Name RP9 pre-mRNA splicing factorprovided by HGNC Primary source HGNC:HGNC:10288 See related Ensembl:ENSG00000164610 MIM:607331; AllianceGenome:HGNC:10288 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAP1; PAP-1 Summary The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre-mRNA splicing. CBF1-interacting protein (CIR), a corepressor of CBF1, can also bind to this protein and effects alternative splicing. Mutations in this gene result in autosomal dominant retinitis pigmentosa-9. This gene has a pseudogene (GeneID: 441212), which is located in tandem array approximately 166 kb distal to this gene. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in testis (RPKM 5.1), adrenal (RPKM 4.6) and 25 other tissues See more Orthologs mouse all
RPA1, Official Symbol RPA1provided by HGNC Official Full Name replication protein A1provided by HGNC Primary source HGNC:HGNC:10289 See related Ensembl:ENSG00000132383 MIM:179835; AllianceGenome:HGNC:10289 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSSB; RF-A; RP-A; REPA1; RPA70; MST075; PFBMFT6 Summary This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017] Expression Ubiquitous expression in lymph node (RPKM 21.6), ovary (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
RPA2, Official Symbol RPA2provided by HGNC Official Full Name replication protein A2provided by HGNC Primary source HGNC:HGNC:10290 See related Ensembl:ENSG00000117748 MIM:179836; AllianceGenome:HGNC:10290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as REPA2; RPA32; RP-A p32; RP-A p34 Summary This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017] Expression Ubiquitous expression in testis (RPKM 29.0), lymph node (RPKM 26.6) and 25 other tissues See more Orthologs mouse all
RPA2P1, Official Symbol RPA2P1provided by HGNC Official Full Name replication protein A2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:19676 See related AllianceGenome:HGNC:19676 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPA2P
RPA2P2, Official Symbol RPA2P2provided by HGNC Official Full Name replication protein A2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:45117 See related AllianceGenome:HGNC:45117 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RPA2P3, Official Symbol RPA2P3provided by HGNC Official Full Name replication protein A2 pseudogene 3provided by HGNC Primary source HGNC:HGNC:45118 See related AllianceGenome:HGNC:45118 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RPA3, Official Symbol RPA3provided by HGNC Official Full Name replication protein A3provided by HGNC Primary source HGNC:HGNC:10291 See related Ensembl:ENSG00000106399 MIM:179837; AllianceGenome:HGNC:10291 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as REPA3; RP-A p14 Summary Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 9.0), bone marrow (RPKM 7.1) and 25 other tissues See more Orthologs mouse all