psui3905/ncbi_genes_summary huggingface dataset:
PPIAP69, Official Symbol PPIAP69provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 69provided by HGNC Primary source HGNC:HGNC:53693 See related Ensembl:ENSG00000228337 AllianceGenome:HGNC:53693 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP75, Official Symbol PPIAP75provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 75provided by HGNC Primary source HGNC:HGNC:53699 See related Ensembl:ENSG00000271131 AllianceGenome:HGNC:53699 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP76, Official Symbol PPIAP76provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 76provided by HGNC Primary source HGNC:HGNC:53700 See related Ensembl:ENSG00000250484 AllianceGenome:HGNC:53700 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP77, Official Symbol PPIAP77provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 77provided by HGNC Primary source HGNC:HGNC:53701 See related AllianceGenome:HGNC:53701 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP83, Official Symbol PPIAP83provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 83provided by HGNC Primary source HGNC:HGNC:53707 See related Ensembl:ENSG00000242978 AllianceGenome:HGNC:53707 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP84, Official Symbol PPIAP84provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 84provided by HGNC Primary source HGNC:HGNC:53708 See related Ensembl:ENSG00000254152 AllianceGenome:HGNC:53708 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP85, Official Symbol PPIAP85provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 85provided by HGNC Primary source HGNC:HGNC:53709 See related AllianceGenome:HGNC:53709 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP86, Official Symbol PPIAP86provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 86provided by HGNC Primary source HGNC:HGNC:53710 See related Ensembl:ENSG00000213873 AllianceGenome:HGNC:53710 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP88, Official Symbol PPIAP88provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 88provided by HGNC Primary source HGNC:HGNC:53712 See related Ensembl:ENSG00000227350 AllianceGenome:HGNC:53712 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP89, Official Symbol PPIAP89provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 89provided by HGNC Primary source HGNC:HGNC:53713 See related AllianceGenome:HGNC:53713 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP90, Official Symbol PPIAP90provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 90provided by HGNC Primary source HGNC:HGNC:53714 See related Ensembl:ENSG00000234557 AllianceGenome:HGNC:53714 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP91, Official Symbol PPIAP91provided by HGNC Official Full Name peptidylprolyl isomerase A pseudogene 91provided by HGNC Primary source HGNC:HGNC:53715 See related Ensembl:ENSG00000228728 AllianceGenome:HGNC:53715 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIAP93, Official Symbol PPIAP93provided by HGNC Official Full Name PPIA pseudogene 93provided by HGNC Primary source HGNC:HGNC:54634 See related Ensembl:ENSG00000227847 AllianceGenome:HGNC:54634 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPIB, Official Symbol PPIBprovided by HGNC Official Full Name peptidylprolyl isomerase Bprovided by HGNC Primary source HGNC:HGNC:9255 See related Ensembl:ENSG00000166794 MIM:123841; AllianceGenome:HGNC:9255 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OI9; CYPB; SCYLP; CYP-S1; HEL-S-39 Summary The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009] Expression Ubiquitous expression in thyroid (RPKM 295.6), placenta (RPKM 241.5) and 25 other tissues See more Orthologs mouse all
PPIC, Official Symbol PPICprovided by HGNC Official Full Name peptidylprolyl isomerase Cprovided by HGNC Primary source HGNC:HGNC:9256 See related Ensembl:ENSG00000168938 MIM:123842; AllianceGenome:HGNC:9256 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPC Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 32.1), placenta (RPKM 29.0) and 24 other tissues See more Orthologs mouse all
PPID, Official Symbol PPIDprovided by HGNC Official Full Name peptidylprolyl isomerase Dprovided by HGNC Primary source HGNC:HGNC:9257 See related Ensembl:ENSG00000171497 MIM:601753; AllianceGenome:HGNC:9257 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPD; CYP-40 Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008] Annotation information Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by Entrez GeneID 10105, PPIF. [13 Feb 2013] Expression Ubiquitous expression in testis (RPKM 15.6), duodenum (RPKM 13.0) and 25 other tissues See more Orthologs mouse all
PPIE, Official Symbol PPIEprovided by HGNC Official Full Name peptidylprolyl isomerase Eprovided by HGNC Primary source HGNC:HGNC:9258 See related Ensembl:ENSG00000084072 MIM:602435; AllianceGenome:HGNC:9258 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP33; CYP-33 Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010] Expression Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
PPIF, Official Symbol PPIFprovided by HGNC Official Full Name peptidylprolyl isomerase Fprovided by HGNC Primary source HGNC:HGNC:9259 See related Ensembl:ENSG00000108179 MIM:604486; AllianceGenome:HGNC:9259 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP3; CypD; CyP-M; Cyp-D Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008] Annotation information Note: This gene encodes a 178 aa mature peptide that is found in the mitochondrion. It has been labeled 'cyclophilin D'. This same name has also been applied to a different cytoplasmic protein of 370 aa, which is represented by Entrez GeneID 5481, PPID. [05 May 2010] Expression Ubiquitous expression in adrenal (RPKM 72.6), bone marrow (RPKM 44.8) and 25 other tissues See more Orthologs mouse all
PPIG, Official Symbol PPIGprovided by HGNC Official Full Name peptidylprolyl isomerase Gprovided by HGNC Primary source HGNC:HGNC:14650 See related Ensembl:ENSG00000138398 MIM:606093; AllianceGenome:HGNC:14650 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP; SRCyp; SCAF10; CARS-Cyp Summary Enables cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in protein peptidyl-prolyl isomerization. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 12.9), endometrium (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
PPIH, Official Symbol PPIHprovided by HGNC Official Full Name peptidylprolyl isomerase Hprovided by HGNC Primary source HGNC:HGNC:14651 See related Ensembl:ENSG00000171960 MIM:606095; AllianceGenome:HGNC:14651 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPH; CYP-20; USA-CYP; SnuCyp-20 Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.7) and 25 other tissues See more Orthologs mouse all
PPIL1, Official Symbol PPIL1provided by HGNC Official Full Name peptidylprolyl isomerase like 1provided by HGNC Primary source HGNC:HGNC:9260 See related Ensembl:ENSG00000137168 MIM:601301; AllianceGenome:HGNC:9260 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPL1; PCH14; hCyPX; PPIase; CGI-124 Summary This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 23.5), thyroid (RPKM 20.4) and 25 other tissues See more Orthologs mouse all
PPIL2, Official Symbol PPIL2provided by HGNC Official Full Name peptidylprolyl isomerase like 2provided by HGNC Primary source HGNC:HGNC:9261 See related Ensembl:ENSG00000100023 MIM:607588; AllianceGenome:HGNC:9261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYC4; CYP60; UBOX7; Cyp-60; hCyP-60 Summary This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in thyroid (RPKM 15.3), lymph node (RPKM 12.4) and 25 other tissues See more Orthologs mouse all
PPIL3, Official Symbol PPIL3provided by HGNC Official Full Name peptidylprolyl isomerase like 3provided by HGNC Primary source HGNC:HGNC:9262 See related Ensembl:ENSG00000240344 MIM:615811; AllianceGenome:HGNC:9262 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPJ Summary This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in lymph node (RPKM 8.6), ovary (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
PPIL4, Official Symbol PPIL4provided by HGNC Official Full Name peptidylprolyl isomerase like 4provided by HGNC Primary source HGNC:HGNC:15702 See related Ensembl:ENSG00000131013 MIM:607609; AllianceGenome:HGNC:15702 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HDCME13P Summary This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 15.0), gall bladder (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
PPIL6, Official Symbol PPIL6provided by HGNC Official Full Name peptidylprolyl isomerase like 6provided by HGNC Primary source HGNC:HGNC:21557 See related Ensembl:ENSG00000185250 AllianceGenome:HGNC:21557 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPIase; RSPH12; bA425D10.6; dJ919F19.1 Summary Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 2.1), thyroid (RPKM 1.7) and 18 other tissues See more Orthologs mouse all
PPIP5K1, Official Symbol PPIP5K1provided by HGNC Official Full Name diphosphoinositol pentakisphosphate kinase 1provided by HGNC Primary source HGNC:HGNC:29023 See related Ensembl:ENSG00000168781 MIM:610979; AllianceGenome:HGNC:29023 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IP6K; IPS1; VIP1; hsVIP1; HISPPD2A Summary This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010] Expression Ubiquitous expression in duodenum (RPKM 8.8), small intestine (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
PPIP5K2, Official Symbol PPIP5K2provided by HGNC Official Full Name diphosphoinositol pentakisphosphate kinase 2provided by HGNC Primary source HGNC:HGNC:29035 See related Ensembl:ENSG00000145725 MIM:611648; AllianceGenome:HGNC:29035 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VIP2; IP7K2; CFAP160; DFNB100; HISPPD1 Summary This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in bone marrow (RPKM 8.5), colon (RPKM 7.8) and 25 other tissues See more Orthologs mouse all
PPL, Official Symbol PPLprovided by HGNC Official Full Name periplakinprovided by HGNC Primary source HGNC:HGNC:9273 See related Ensembl:ENSG00000118898 MIM:602871; AllianceGenome:HGNC:9273 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 300.0) and skin (RPKM 63.7) See more Orthologs mouse all
PPM1A, Official Symbol PPM1Aprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Aprovided by HGNC Primary source HGNC:HGNC:9275 See related Ensembl:ENSG00000100614 MIM:606108; AllianceGenome:HGNC:9275 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CA; PP2Calpha; PP2C-ALPHA Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
PPM1AP1, Official Symbol PPM1AP1provided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene 1provided by HGNC Primary source HGNC:HGNC:30175 See related Ensembl:ENSG00000250483 AllianceGenome:HGNC:30175 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPM1B, Official Symbol PPM1Bprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Bprovided by HGNC Primary source HGNC:HGNC:9276 See related Ensembl:ENSG00000138032 MIM:603770; AllianceGenome:HGNC:9276 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 9.6), brain (RPKM 8.7) and 25 other tissues See more Orthologs mouse all
PPM1B-DT, Official Symbol PPM1B-DTprovided by HGNC Official Full Name PPM1B divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55161 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.7) See more
PPM1D, Official Symbol PPM1Dprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Dprovided by HGNC Primary source HGNC:HGNC:9277 See related Ensembl:ENSG00000170836 MIM:605100; AllianceGenome:HGNC:9277 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JDVS; WIP1; IDDGIP; PP2C-DELTA Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 7.0), ovary (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
PPM1E, Official Symbol PPM1Eprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Eprovided by HGNC Primary source HGNC:HGNC:19322 See related Ensembl:ENSG00000175175 MIM:619308; AllianceGenome:HGNC:19322 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POPX1; PP2CH; caMKN; CAMKPN; CaMKP-N Summary This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] Expression Biased expression in brain (RPKM 6.5), testis (RPKM 3.8) and 3 other tissues See more Orthologs mouse all
PPM1F, Official Symbol PPM1Fprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Fprovided by HGNC Primary source HGNC:HGNC:19388 See related Ensembl:ENSG00000100034 MIM:619309; AllianceGenome:HGNC:19388 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 16.9), spleen (RPKM 14.5) and 24 other tissues See more Orthologs mouse all
PPM1G, Official Symbol PPM1Gprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Gprovided by HGNC Primary source HGNC:HGNC:9278 See related Ensembl:ENSG00000115241 MIM:605119; AllianceGenome:HGNC:9278 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CG; PPP2CG; PP2CGAMMA Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] Expression Broad expression in testis (RPKM 133.0), lymph node (RPKM 28.8) and 24 other tissues See more Orthologs mouse all
PPM1H, Official Symbol PPM1Hprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Hprovided by HGNC Primary source HGNC:HGNC:18583 See related Ensembl:ENSG00000111110 MIM:616016; AllianceGenome:HGNC:18583 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as URCC2; ARHCL1; NERPP-2C Summary Enables identical protein binding activity and phosphoprotein phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 7.7), prostate (RPKM 6.7) and 23 other tissues See more Orthologs mouse all
PPM1J, Official Symbol PPM1Jprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Jprovided by HGNC Primary source HGNC:HGNC:20785 See related Ensembl:ENSG00000155367 MIM:609957; AllianceGenome:HGNC:20785 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CZ; PPP2CZ; PP2Czeta; PP2C-zeta Summary This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 22.7), skin (RPKM 8.1) and 5 other tissues See more Orthologs mouse all
PPM1J-DT, Official Symbol PPM1J-DTprovided by HGNC Official Full Name PPM1J divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55355 See related AllianceGenome:HGNC:55355 Gene type ncRNA RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.9) See more
PPM1K, Official Symbol PPM1Kprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Kprovided by HGNC Primary source HGNC:HGNC:25415 See related Ensembl:ENSG00000163644 MIM:611065; AllianceGenome:HGNC:25415 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDP; PTMP; PP2Cm; MSUDMV; PP2Ckappa; UG0882E07 Summary This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012] Expression Broad expression in heart (RPKM 22.0), endometrium (RPKM 10.0) and 22 other tissues See more Orthologs mouse all
PPM1K-DT, Official Symbol PPM1K-DTprovided by HGNC Official Full Name PPM1K divergent transcriptprovided by HGNC Primary source HGNC:HGNC:54093 See related Ensembl:ENSG00000246375 AllianceGenome:HGNC:54093 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PPM1L, Official Symbol PPM1Lprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Lprovided by HGNC Primary source HGNC:HGNC:16381 See related Ensembl:ENSG00000163590 MIM:611931; AllianceGenome:HGNC:16381 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CE; PPM1-LIKE; PP2C-epsilon Summary The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in brain (RPKM 9.7), thyroid (RPKM 6.9) and 24 other tissues See more Orthologs mouse all
PPM1M, Official Symbol PPM1Mprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1Mprovided by HGNC Primary source HGNC:HGNC:26506 See related Ensembl:ENSG00000164088 MIM:608979; AllianceGenome:HGNC:26506 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CE; PP2Ceta; PP2C-eta Summary Predicted to enable manganese ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 16.5), spleen (RPKM 14.7) and 25 other tissues See more Orthologs mouse all
PPM1N, Official Symbol PPM1Nprovided by HGNC Official Full Name protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)provided by HGNC Primary source HGNC:HGNC:26845 See related Ensembl:ENSG00000213889 AllianceGenome:HGNC:26845 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 1.5), lymph node (RPKM 0.6) and 20 other tissues See more Orthologs mouse all
PPME1, Official Symbol PPME1provided by HGNC Official Full Name protein phosphatase methylesterase 1provided by HGNC Primary source HGNC:HGNC:30178 See related Ensembl:ENSG00000214517 MIM:611117; AllianceGenome:HGNC:30178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PME-1; ABDH19 Summary This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 17.5) and 25 other tissues See more Orthologs mouse all
PPOX, Official Symbol PPOXprovided by HGNC Official Full Name protoporphyrinogen oxidaseprovided by HGNC Primary source HGNC:HGNC:9280 See related Ensembl:ENSG00000143224 MIM:600923; AllianceGenome:HGNC:9280 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VP; PPO; VPCO; V290M Summary This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 6.3), skin (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
PPP1CA, Official Symbol PPP1CAprovided by HGNC Official Full Name protein phosphatase 1 catalytic subunit alphaprovided by HGNC Primary source HGNC:HGNC:9281 See related Ensembl:ENSG00000172531 MIM:176875; AllianceGenome:HGNC:9281 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP1A; PP-1A; PPP1A; PP1alpha Summary The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020] Expression Ubiquitous expression in lymph node (RPKM 67.2), colon (RPKM 56.9) and 25 other tissues See more Orthologs mouse all
PPP1CB, Official Symbol PPP1CBprovided by HGNC Official Full Name protein phosphatase 1 catalytic subunit betaprovided by HGNC Primary source HGNC:HGNC:9282 See related Ensembl:ENSG00000213639 MIM:600590; AllianceGenome:HGNC:9282 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p Summary The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 80.9), prostate (RPKM 58.5) and 25 other tissues See more Orthologs mouse all
PPP1CC, Official Symbol PPP1CCprovided by HGNC Official Full Name protein phosphatase 1 catalytic subunit gammaprovided by HGNC Primary source HGNC:HGNC:9283 See related Ensembl:ENSG00000186298 MIM:176914; AllianceGenome:HGNC:9283 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP1C; PP-1G; PPP1G Summary The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues See more Orthologs mouse all
PPP1R10, Official Symbol PPP1R10provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 10provided by HGNC Primary source HGNC:HGNC:9284 See related Ensembl:ENSG00000204569 MIM:603771; AllianceGenome:HGNC:9284 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p99; FB19; R111; CAT53; PNUTS; PP1R10 Summary This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 17.1), adrenal (RPKM 16.4) and 25 other tissues See more Orthologs mouse all
PPP1R10P1, Official Symbol PPP1R10P1provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 10 pseudogene 1provided by HGNC Primary source HGNC:HGNC:16325 See related Ensembl:ENSG00000255352 AllianceGenome:HGNC:16325 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPP1R10P
PPP1R11, Official Symbol PPP1R11provided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 11provided by HGNC Primary source HGNC:HGNC:9285 See related Ensembl:ENSG00000204619 MIM:606670; AllianceGenome:HGNC:9285 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255 Summary This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in small intestine (RPKM 46.4), thyroid (RPKM 45.6) and 25 other tissues See more Orthologs mouse all
PPP1R11P2, Official Symbol PPP1R11P2provided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 11 pseudogene 2provided by HGNC Primary source HGNC:HGNC:16327 See related Ensembl:ENSG00000231765 AllianceGenome:HGNC:16327 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPP1R12A, Official Symbol PPP1R12Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 12Aprovided by HGNC Primary source HGNC:HGNC:7618 See related Ensembl:ENSG00000058272 MIM:602021; AllianceGenome:HGNC:7618 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MBS; GUBS; M130; MYPT1 Summary Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] Expression Ubiquitous expression in endometrium (RPKM 18.7), esophagus (RPKM 16.4) and 24 other tissues See more Orthologs mouse all