psui3905/ncbi_genes_summary huggingface dataset:
ZNF836, Official Symbol ZNF836provided by HGNC Official Full Name zinc finger protein 836provided by HGNC Primary source HGNC:HGNC:34333 See related Ensembl:ENSG00000196267 AllianceGenome:HGNC:34333 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 5.5), ovary (RPKM 1.8) and 24 other tissues See more Orthologs all
ZNF837, Official Symbol ZNF837provided by HGNC Official Full Name zinc finger protein 837provided by HGNC Primary source HGNC:HGNC:25164 See related Ensembl:ENSG00000152475 AllianceGenome:HGNC:25164 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
ZNF839, Official Symbol ZNF839provided by HGNC Official Full Name zinc finger protein 839provided by HGNC Primary source HGNC:HGNC:20345 See related Ensembl:ENSG00000022976 AllianceGenome:HGNC:20345 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C14orf131 Summary Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 6.0), spleen (RPKM 2.7) and 25 other tissues See more Orthologs mouse all
ZNF839P1, Official Symbol ZNF839P1provided by HGNC Official Full Name zinc finger protein 839 pseudogene 1provided by HGNC Primary source HGNC:HGNC:38455 See related Ensembl:ENSG00000217896 AllianceGenome:HGNC:38455 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF84, Official Symbol ZNF84provided by HGNC Official Full Name zinc finger protein 84provided by HGNC Primary source HGNC:HGNC:13159 See related Ensembl:ENSG00000198040 MIM:618554; AllianceGenome:HGNC:13159 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPF2 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 7.4), endometrium (RPKM 6.1) and 25 other tissues See more Orthologs all
ZNF84-DT, Official Symbol ZNF84-DTprovided by HGNC Official Full Name ZNF84 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53355 See related Ensembl:ENSG00000246394 AllianceGenome:HGNC:53355 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.7) See more
ZNF841, Official Symbol ZNF841provided by HGNC Official Full Name zinc finger protein 841provided by HGNC Primary source HGNC:HGNC:27611 See related Ensembl:ENSG00000197608 AllianceGenome:HGNC:27611 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 3.7), endometrium (RPKM 2.9) and 25 other tissues See more Orthologs all
ZNF843, Official Symbol ZNF843provided by HGNC Official Full Name zinc finger protein 843provided by HGNC Primary source HGNC:HGNC:28710 See related Ensembl:ENSG00000176723 AllianceGenome:HGNC:28710 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
ZNF844, Official Symbol ZNF844provided by HGNC Official Full Name zinc finger protein 844provided by HGNC Primary source HGNC:HGNC:25932 See related Ensembl:ENSG00000223547 AllianceGenome:HGNC:25932 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 5.6), ovary (RPKM 4.7) and 25 other tissues See more Orthologs all
ZNF845, Official Symbol ZNF845provided by HGNC Official Full Name zinc finger protein 845provided by HGNC Primary source HGNC:HGNC:25112 See related Ensembl:ENSG00000213799 AllianceGenome:HGNC:25112 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 2.2), thyroid (RPKM 2.2) and 25 other tissues See more Orthologs all
ZNF846, Official Symbol ZNF846provided by HGNC Official Full Name zinc finger protein 846provided by HGNC Primary source HGNC:HGNC:27260 See related Ensembl:ENSG00000196605 AllianceGenome:HGNC:27260 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 2.6), brain (RPKM 2.1) and 25 other tissues See more Orthologs all
ZNF849P, Official Symbol ZNF849Pprovided by HGNC Official Full Name zinc finger protein 849, pseudogeneprovided by HGNC Primary source HGNC:HGNC:34389 See related Ensembl:ENSG00000198153 AllianceGenome:HGNC:34389 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF85, Official Symbol ZNF85provided by HGNC Official Full Name zinc finger protein 85provided by HGNC Primary source HGNC:HGNC:13160 See related Ensembl:ENSG00000105750 MIM:603899; AllianceGenome:HGNC:13160 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPF4; HTF1 Summary Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 3.9), thyroid (RPKM 2.6) and 21 other tissues See more Orthologs all
ZNF850, Official Symbol ZNF850provided by HGNC Official Full Name zinc finger protein 850provided by HGNC Primary source HGNC:HGNC:27994 See related Ensembl:ENSG00000267041 AllianceGenome:HGNC:27994 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF850P Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 1.4), placenta (RPKM 0.7) and 23 other tissues See more Orthologs all
ZNF852, Official Symbol ZNF852provided by HGNC Official Full Name zinc finger protein 852provided by HGNC Primary source HGNC:HGNC:27713 See related Ensembl:ENSG00000178917 AllianceGenome:HGNC:27713 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Annotation category: suggests misassembly Expression Ubiquitous expression in prostate (RPKM 1.1), spleen (RPKM 1.0) and 25 other tissues See more Orthologs all
ZNF853, Official Symbol ZNF853provided by HGNC Official Full Name zinc finger protein 853provided by HGNC Primary source HGNC:HGNC:21767 See related Ensembl:ENSG00000236609 AllianceGenome:HGNC:21767 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 5.7), brain (RPKM 5.5) and 23 other tissues See more Orthologs mouse all
ZNF859P, Official Symbol ZNF859Pprovided by HGNC Official Full Name zinc finger protein 859, pseudogeneprovided by HGNC Primary source HGNC:HGNC:34507 See related AllianceGenome:HGNC:34507 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF860, Official Symbol ZNF860provided by HGNC Official Full Name zinc finger protein 860provided by HGNC Primary source HGNC:HGNC:34513 See related Ensembl:ENSG00000197385 AllianceGenome:HGNC:34513 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 1.1), prostate (RPKM 0.9) and 21 other tissues See more Orthologs all
ZNF861P, Official Symbol ZNF861Pprovided by HGNC Official Full Name zinc finger protein 861, pseudogeneprovided by HGNC Primary source HGNC:HGNC:34514 See related Ensembl:ENSG00000267235 AllianceGenome:HGNC:34514 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
ZNF862, Official Symbol ZNF862provided by HGNC Official Full Name zinc finger protein 862provided by HGNC Primary source HGNC:HGNC:34519 See related Ensembl:ENSG00000106479 AllianceGenome:HGNC:34519 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity and protein dimerization activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 4.4), thyroid (RPKM 4.0) and 25 other tissues See more Orthologs all
ZNF865, Official Symbol ZNF865provided by HGNC Official Full Name zinc finger protein 865provided by HGNC Primary source HGNC:HGNC:38705 See related Ensembl:ENSG00000261221 AllianceGenome:HGNC:38705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
ZNF875, Official Symbol ZNF875provided by HGNC Official Full Name zinc finger protein 875provided by HGNC Primary source HGNC:HGNC:4928 See related Ensembl:ENSG00000181666 MIM:165250; AllianceGenome:HGNC:4928 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HKR1 Summary Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in prostate (RPKM 5.1), thyroid (RPKM 4.9) and 25 other tissues See more Orthologs all
ZNF876P, Official Symbol ZNF876Pprovided by HGNC Official Full Name zinc finger protein 876, pseudogeneprovided by HGNC Primary source HGNC:HGNC:32472 See related Ensembl:ENSG00000290382 AllianceGenome:HGNC:32472 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 2.4), thyroid (RPKM 0.7) and 20 other tissues See more
ZNF878, Official Symbol ZNF878provided by HGNC Official Full Name zinc finger protein 878provided by HGNC Primary source HGNC:HGNC:37246 See related Ensembl:ENSG00000257446 AllianceGenome:HGNC:37246 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
ZNF879, Official Symbol ZNF879provided by HGNC Official Full Name zinc finger protein 879provided by HGNC Primary source HGNC:HGNC:37273 See related Ensembl:ENSG00000234284 AllianceGenome:HGNC:37273 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKFZp686E2433 Summary This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017] Expression Broad expression in testis (RPKM 2.9), thyroid (RPKM 1.6) and 24 other tissues See more Orthologs mouse all
ZNF880, Official Symbol ZNF880provided by HGNC Official Full Name zinc finger protein 880provided by HGNC Primary source HGNC:HGNC:37249 See related Ensembl:ENSG00000221923 AllianceGenome:HGNC:37249 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 3.2), ovary (RPKM 2.5) and 25 other tissues See more Orthologs all
ZNF883, Official Symbol ZNF883provided by HGNC Official Full Name zinc finger protein 883provided by HGNC Primary source HGNC:HGNC:27271 See related Ensembl:ENSG00000228623 AllianceGenome:HGNC:27271 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 3.0), heart (RPKM 1.5) and 19 other tissues See more Orthologs all
ZNF888, Official Symbol ZNF888provided by HGNC Official Full Name zinc finger protein 888provided by HGNC Primary source HGNC:HGNC:38695 See related Ensembl:ENSG00000213793 AllianceGenome:HGNC:38695 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in urinary bladder (RPKM 7.4), prostate (RPKM 5.4) and 24 other tissues See more Orthologs all
ZNF891, Official Symbol ZNF891provided by HGNC Official Full Name zinc finger protein 891provided by HGNC Primary source HGNC:HGNC:38709 See related Ensembl:ENSG00000214029 AllianceGenome:HGNC:38709 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 1.3), thyroid (RPKM 0.9) and 24 other tissues See more Orthologs all
ZNF90, Official Symbol ZNF90provided by HGNC Official Full Name zinc finger protein 90provided by HGNC Primary source HGNC:HGNC:13165 See related Ensembl:ENSG00000213988 MIM:603973; AllianceGenome:HGNC:13165 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HTF9 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 9.1), lymph node (RPKM 5.0) and 25 other tissues See more Orthologs all
ZNF91, Official Symbol ZNF91provided by HGNC Official Full Name zinc finger protein 91provided by HGNC Primary source HGNC:HGNC:13166 See related Ensembl:ENSG00000167232 MIM:603971; AllianceGenome:HGNC:13166 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPF7; HTF10 Summary The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010] Expression Ubiquitous expression in small intestine (RPKM 3.5), thyroid (RPKM 3.3) and 25 other tissues See more Orthologs all
ZNF92, Official Symbol ZNF92provided by HGNC Official Full Name zinc finger protein 92provided by HGNC Primary source HGNC:HGNC:13168 See related Ensembl:ENSG00000146757 MIM:603974; AllianceGenome:HGNC:13168 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TF12; HPF12; HTF12; HEL-203 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 2.6), bone marrow (RPKM 2.5) and 25 other tissues See more Orthologs all
ZNF92P1Y, Official Symbol ZNF92P1Yprovided by HGNC Official Full Name zinc finger protein 92 pseudogene 1, Y-linkedprovided by HGNC Primary source HGNC:HGNC:39553 See related Ensembl:ENSG00000215603 AllianceGenome:HGNC:39553 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF92P2, Official Symbol ZNF92P2provided by HGNC Official Full Name zinc finger protein 92 pseudogene 2provided by HGNC Primary source HGNC:HGNC:39554 See related AllianceGenome:HGNC:39554 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF93, Official Symbol ZNF93provided by HGNC Official Full Name zinc finger protein 93provided by HGNC Primary source HGNC:HGNC:13169 See related Ensembl:ENSG00000184635 MIM:603975; AllianceGenome:HGNC:13169 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TF34; HPF34; HTF34; ZNF505 Summary Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription, DNA-templated and negative regulation of transposon integration. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 2.7), urinary bladder (RPKM 1.7) and 25 other tissues See more Orthologs all
ZNF962P, Official Symbol ZNF962Pprovided by HGNC Official Full Name zinc finger protein 962, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39250 See related Ensembl:ENSG00000215604 AllianceGenome:HGNC:39250 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF965P, Official Symbol ZNF965Pprovided by HGNC Official Full Name zinc finger protein 965, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42025 See related AllianceGenome:HGNC:42025 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF969P, Official Symbol ZNF969Pprovided by HGNC Official Full Name zinc finger protein 969, pseudogeneprovided by HGNC Primary source HGNC:HGNC:44211 See related Ensembl:ENSG00000251046 AllianceGenome:HGNC:44211 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNF98, Official Symbol ZNF98provided by HGNC Official Full Name zinc finger protein 98provided by HGNC Primary source HGNC:HGNC:13174 See related Ensembl:ENSG00000197360 MIM:603980; AllianceGenome:HGNC:13174 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as F7175; ZNF739 Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 2.3), kidney (RPKM 0.7) and 13 other tissues See more
ZNF99, Official Symbol ZNF99provided by HGNC Official Full Name zinc finger protein 99provided by HGNC Primary source HGNC:HGNC:13175 See related Ensembl:ENSG00000213973 MIM:603981; AllianceGenome:HGNC:13175 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as F8281; C19orf9 Summary Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 1.1), brain (RPKM 0.1) and 2 other tissues See more
ZNFX1, Official Symbol ZNFX1provided by HGNC Official Full Name zinc finger NFX1-type containing 1provided by HGNC Primary source HGNC:HGNC:29271 See related Ensembl:ENSG00000124201 MIM:618931; AllianceGenome:HGNC:29271 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD91 Summary Enables RNA binding activity. Predicted to be involved in heterochromatin assembly by small RNA. Predicted to be part of nuclear RNA-directed RNA polymerase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lung (RPKM 11.1), spleen (RPKM 10.7) and 25 other tissues See more Orthologs mouse all
ZNHIT1, Official Symbol ZNHIT1provided by HGNC Official Full Name zinc finger HIT-type containing 1provided by HGNC Primary source HGNC:HGNC:21688 See related Ensembl:ENSG00000106400 MIM:618617; AllianceGenome:HGNC:21688 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CG1I; ZNFN4A1 Summary Predicted to enable histone deacetylase binding activity and nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to act upstream of or within several processes, including negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of histone deacetylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in liver (RPKM 23.5), kidney (RPKM 21.2) and 25 other tissues See more Orthologs mouse all
ZNHIT2, Official Symbol ZNHIT2provided by HGNC Official Full Name zinc finger HIT-type containing 2provided by HGNC Primary source HGNC:HGNC:1177 See related Ensembl:ENSG00000174276 MIM:604575; AllianceGenome:HGNC:1177 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FON; C11orf5 Summary Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
ZNHIT3, Official Symbol ZNHIT3provided by HGNC Official Full Name zinc finger HIT-type containing 3provided by HGNC Primary source HGNC:HGNC:12309 See related Ensembl:ENSG00000273611 MIM:604500; AllianceGenome:HGNC:12309 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hit1; PEHO; TRIP3 Summary Predicted to enable thyroid hormone receptor binding activity. Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Located in cytoplasm and nucleus. Implicated in PEHO syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 10.5), testis (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
ZNHIT6, Official Symbol ZNHIT6provided by HGNC Official Full Name zinc finger HIT-type containing 6provided by HGNC Primary source HGNC:HGNC:26089 See related Ensembl:ENSG00000117174 MIM:620473; AllianceGenome:HGNC:26089 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCD1; C1orf181; NY-BR-75 Summary Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Involved in box C/D snoRNP assembly; protein complex oligomerization; and snoRNA localization. Located in extracellular exosome. Part of pre-snoRNP complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 2.7), endometrium (RPKM 2.7) and 25 other tissues See more Orthologs mouse all
ZNNT1, Official Symbol ZNNT1provided by HGNC Official Full Name ZNF706 neighboring transcript 1provided by HGNC Primary source HGNC:HGNC:54438 See related Ensembl:ENSG00000261087 AllianceGenome:HGNC:54438 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZNRD2, Official Symbol ZNRD2provided by HGNC Official Full Name zinc ribbon domain containing 2provided by HGNC Primary source HGNC:HGNC:11328 See related Ensembl:ENSG00000173465 MIM:606044; AllianceGenome:HGNC:11328 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p27; SSSCA1 Summary This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 11.4), bone marrow (RPKM 10.2) and 25 other tissues See more Orthologs mouse all
ZNRF1, Official Symbol ZNRF1provided by HGNC Official Full Name zinc and ring finger 1provided by HGNC Primary source HGNC:HGNC:18452 See related Ensembl:ENSG00000186187 MIM:612060; AllianceGenome:HGNC:18452 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIN283 Summary This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in testis (RPKM 4.3), thyroid (RPKM 4.3) and 25 other tissues See more Orthologs mouse all
ZNRF2, Official Symbol ZNRF2provided by HGNC Official Full Name zinc and ring finger 2provided by HGNC Primary source HGNC:HGNC:22316 See related Ensembl:ENSG00000180233 MIM:612061; AllianceGenome:HGNC:22316 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF202 Summary Enables ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 15.0), colon (RPKM 12.4) and 25 other tissues See more Orthologs mouse all
ZNRF3, Official Symbol ZNRF3provided by HGNC Official Full Name zinc and ring finger 3provided by HGNC Primary source HGNC:HGNC:18126 See related Ensembl:ENSG00000183579 MIM:612062; AllianceGenome:HGNC:18126 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF203; BK747E2.3 Summary Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in cellular protein metabolic process and negative regulation of Wnt signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 4.8), brain (RPKM 4.7) and 24 other tissues See more Orthologs mouse all
ZNRF3-AS1, Official Symbol ZNRF3-AS1provided by HGNC Official Full Name ZNRF3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41927 See related Ensembl:ENSG00000177993 AllianceGenome:HGNC:41927 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
ZNRF4, Official Symbol ZNRF4provided by HGNC Official Full Name zinc and ring finger 4provided by HGNC Primary source HGNC:HGNC:17726 See related Ensembl:ENSG00000105428 MIM:612063; AllianceGenome:HGNC:17726 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as spzn; RNF204; Ssrzf1; SPERIZIN Summary Predicted to enable ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
ZP1, Official Symbol ZP1provided by HGNC Official Full Name zona pellucida glycoprotein 1provided by HGNC Primary source HGNC:HGNC:13187 See related Ensembl:ENSG00000149506 MIM:195000; AllianceGenome:HGNC:13187 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OOMD; ZPB1; OOMD1; HEL163; OZEMA1 Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014] Expression Biased expression in testis (RPKM 1.8), fat (RPKM 0.3) and 2 other tissues See more Orthologs mouse all
ZP2, Official Symbol ZP2provided by HGNC Official Full Name zona pellucida glycoprotein 2provided by HGNC Primary source HGNC:HGNC:13188 See related Ensembl:ENSG00000103310 MIM:182888; AllianceGenome:HGNC:13188 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZPA; Zp-2; OOMD6; OZEMA6 Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Low expression observed in reference dataset See more Orthologs mouse all
ZP3, Official Symbol ZP3provided by HGNC Official Full Name zona pellucida glycoprotein 3provided by HGNC Primary source HGNC:HGNC:13189 See related Ensembl:ENSG00000188372 MIM:182889; AllianceGenome:HGNC:13189 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZPC; ZP3A; ZP3B; Zp-3; OOMD3; OZEMA3 Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 5.0), skin (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
ZP3P1, Official Symbol ZP3P1provided by HGNC Official Full Name ZP3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50856 See related Ensembl:ENSG00000250013 AllianceGenome:HGNC:50856 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ZP4, Official Symbol ZP4provided by HGNC Official Full Name zona pellucida glycoprotein 4provided by HGNC Primary source HGNC:HGNC:15770 See related Ensembl:ENSG00000116996 MIM:613514; AllianceGenome:HGNC:15770 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZBP; ZP1; ZPB; ZP1B; ZPB2; Zp-4 Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
ZPBP, Official Symbol ZPBPprovided by HGNC Official Full Name zona pellucida binding proteinprovided by HGNC Primary source HGNC:HGNC:15662 See related Ensembl:ENSG00000042813 MIM:608498; AllianceGenome:HGNC:15662 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZPBP1; SPGF66 Summary ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008] Expression Restricted expression toward testis (RPKM 37.4) See more Orthologs mouse all
ZPBP2, Official Symbol ZPBP2provided by HGNC Official Full Name zona pellucida binding protein 2provided by HGNC Primary source HGNC:HGNC:20678 See related Ensembl:ENSG00000186075 MIM:608499; AllianceGenome:HGNC:20678 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZPBPL Summary Predicted to be involved in acrosome assembly and binding activity of sperm to zona pellucida. Predicted to act upstream of or within membrane lipid metabolic process and regulation of gene expression. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 54.6) See more Orthologs mouse all