psui3905/ncbi_genes_summary huggingface dataset:
TRIL, Official Symbol TRILprovided by HGNC Official Full Name TLR4 interactor with leucine rich repeatsprovided by HGNC Primary source HGNC:HGNC:22200 See related Ensembl:ENSG00000255690 MIM:613356; AllianceGenome:HGNC:22200 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010] Orthologs mouse all
TRIM10, Official Symbol TRIM10provided by HGNC Official Full Name tripartite motif containing 10provided by HGNC Primary source HGNC:HGNC:10072 See related Ensembl:ENSG00000204613 MIM:605701; AllianceGenome:HGNC:10072 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF9; HERF1; RFB30 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 6.5), kidney (RPKM 1.8) and 6 other tissues See more Orthologs mouse all
TRIM11, Official Symbol TRIM11provided by HGNC Official Full Name tripartite motif containing 11provided by HGNC Primary source HGNC:HGNC:16281 See related Ensembl:ENSG00000154370 MIM:607868; AllianceGenome:HGNC:16281 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIA1; RNF92 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues See more Orthologs mouse all
TRIM13, Official Symbol TRIM13provided by HGNC Official Full Name tripartite motif containing 13provided by HGNC Primary source HGNC:HGNC:9976 See related Ensembl:ENSG00000204977 MIM:605661; AllianceGenome:HGNC:9976 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAR; LEU5; RFP2; DLEU5; RNF77 Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 17.7), bone marrow (RPKM 8.8) and 25 other tissues See more Orthologs mouse all
TRIM14, Official Symbol TRIM14provided by HGNC Official Full Name tripartite motif containing 14provided by HGNC Primary source HGNC:HGNC:16283 See related Ensembl:ENSG00000106785 MIM:606556; AllianceGenome:HGNC:16283 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in colon (RPKM 8.0), small intestine (RPKM 7.7) and 24 other tissues See more Orthologs mouse all
TRIM15, Official Symbol TRIM15provided by HGNC Official Full Name tripartite motif containing 15provided by HGNC Primary source HGNC:HGNC:16284 See related Ensembl:ENSG00000204610 AllianceGenome:HGNC:16284 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF93; ZNFB7; ZNF178 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in duodenum (RPKM 12.6), small intestine (RPKM 9.2) and 6 other tissues See more Orthologs mouse all
TRIM16, Official Symbol TRIM16provided by HGNC Official Full Name tripartite motif containing 16provided by HGNC Primary source HGNC:HGNC:17241 See related Ensembl:ENSG00000221926 MIM:609505; AllianceGenome:HGNC:17241 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EBBP Summary The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017] Expression Broad expression in esophagus (RPKM 47.9), placenta (RPKM 17.3) and 19 other tissues See more Orthologs mouse all
TRIM16L, Official Symbol TRIM16Lprovided by HGNC Official Full Name tripartite motif containing 16 like (pseudogene)provided by HGNC Primary source HGNC:HGNC:32670 See related Ensembl:ENSG00000291110 AllianceGenome:HGNC:32670 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIM70 Summary Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 13.7), gall bladder (RPKM 5.6) and 24 other tissues See more Orthologs all
TRIM17, Official Symbol TRIM17provided by HGNC Official Full Name tripartite motif containing 17provided by HGNC Primary source HGNC:HGNC:13430 See related Ensembl:ENSG00000162931 MIM:606123; AllianceGenome:HGNC:13430 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RBCC; terf; RNF16 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 5.7), spleen (RPKM 1.3) and 11 other tissues See more Orthologs mouse all
TRIM2, Official Symbol TRIM2provided by HGNC Official Full Name tripartite motif containing 2provided by HGNC Primary source HGNC:HGNC:15974 See related Ensembl:ENSG00000109654 MIM:614141; AllianceGenome:HGNC:15974 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMT2R; RNF86 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] Expression Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues See more Orthologs mouse all
TRIM21, Official Symbol TRIM21provided by HGNC Official Full Name tripartite motif containing 21provided by HGNC Primary source HGNC:HGNC:11312 See related Ensembl:ENSG00000132109 MIM:109092; AllianceGenome:HGNC:11312 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SSA; RO52; SSA1; RNF81; Ro/SSA Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 15.5), appendix (RPKM 13.2) and 24 other tissues See more Orthologs mouse all
TRIM22, Official Symbol TRIM22provided by HGNC Official Full Name tripartite motif containing 22provided by HGNC Primary source HGNC:HGNC:16379 See related Ensembl:ENSG00000132274 MIM:606559; AllianceGenome:HGNC:16379 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF94; STAF50; GPSTAF50 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein is involved in innate immunity against different DNA and RNA viruses. [provided by RefSeq, Oct 2021] Expression Broad expression in spleen (RPKM 83.9), lymph node (RPKM 70.5) and 24 other tissues See more Orthologs all
TRIM23, Official Symbol TRIM23provided by HGNC Official Full Name tripartite motif containing 23provided by HGNC Primary source HGNC:HGNC:660 See related Ensembl:ENSG00000113595 MIM:601747; AllianceGenome:HGNC:660 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARD1; ARFD1; RNF46 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 18.0), prostate (RPKM 7.0) and 24 other tissues See more Orthologs mouse all
TRIM24, Official Symbol TRIM24provided by HGNC Official Full Name tripartite motif containing 24provided by HGNC Primary source HGNC:HGNC:11812 See related Ensembl:ENSG00000122779 MIM:603406; AllianceGenome:HGNC:11812 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA Summary The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 19.9), ovary (RPKM 16.3) and 25 other tissues See more Orthologs mouse all
TRIM25, Official Symbol TRIM25provided by HGNC Official Full Name tripartite motif containing 25provided by HGNC Primary source HGNC:HGNC:12932 See related Ensembl:ENSG00000121060 MIM:600453; AllianceGenome:HGNC:12932 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EFP; Z147; RNF147; ZNF147 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in bone marrow (RPKM 21.8), skin (RPKM 15.8) and 25 other tissues See more Orthologs mouse all
TRIM26, Official Symbol TRIM26provided by HGNC Official Full Name tripartite motif containing 26provided by HGNC Primary source HGNC:HGNC:12962 See related Ensembl:ENSG00000234127 MIM:600830; AllianceGenome:HGNC:12962 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AFP; RNF95; ZNF173 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011] Expression Ubiquitous expression in kidney (RPKM 14.9), spleen (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
TRIM27, Official Symbol TRIM27provided by HGNC Official Full Name tripartite motif containing 27provided by HGNC Primary source HGNC:HGNC:9975 See related Ensembl:ENSG00000204713 MIM:602165; AllianceGenome:HGNC:9975 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RFP; RNF76 Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 14.7), spleen (RPKM 14.3) and 25 other tissues See more Orthologs mouse all
TRIM28, Official Symbol TRIM28provided by HGNC Official Full Name tripartite motif containing 28provided by HGNC Primary source HGNC:HGNC:16384 See related Ensembl:ENSG00000130726 MIM:601742; AllianceGenome:HGNC:16384 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KAP1; TF1B; RNF96; TIF1B; PPP1R157; TIF1beta Summary The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 89.1), testis (RPKM 80.5) and 25 other tissues See more Orthologs mouse all
TRIM29, Official Symbol TRIM29provided by HGNC Official Full Name tripartite motif containing 29provided by HGNC Primary source HGNC:HGNC:17274 See related Ensembl:ENSG00000137699 MIM:610658; AllianceGenome:HGNC:17274 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATDC Summary The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 274.4), skin (RPKM 264.0) and 4 other tissues See more Orthologs mouse all
TRIM3, Official Symbol TRIM3provided by HGNC Official Full Name tripartite motif containing 3provided by HGNC Primary source HGNC:HGNC:10064 See related Ensembl:ENSG00000110171 MIM:605493; AllianceGenome:HGNC:10064 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BERP; HAC1; RNF22; RNF97 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
TRIM31, Official Symbol TRIM31provided by HGNC Official Full Name tripartite motif containing 31provided by HGNC Primary source HGNC:HGNC:16289 See related Ensembl:ENSG00000204616 MIM:609316; AllianceGenome:HGNC:16289 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF; HCG1; HCGI; C6orf13 Summary This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Expression Biased expression in colon (RPKM 26.2), urinary bladder (RPKM 20.1) and 5 other tissues See more Orthologs mouse all
TRIM31-AS1, Official Symbol TRIM31-AS1provided by HGNC Official Full Name TRIM31 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39761 See related Ensembl:ENSG00000231226 AllianceGenome:HGNC:39761 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in colon (RPKM 5.7), duodenum (RPKM 4.3) and 6 other tissues See more
TRIM32, Official Symbol TRIM32provided by HGNC Official Full Name tripartite motif containing 32provided by HGNC Primary source HGNC:HGNC:16380 See related Ensembl:ENSG00000119401 MIM:602290; AllianceGenome:HGNC:16380 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HT2A; BBS11; TATIP; LGMD2H; LGMDR8 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 1.6), adrenal (RPKM 1.5) and 24 other tissues See more Orthologs mouse all
TRIM33, Official Symbol TRIM33provided by HGNC Official Full Name tripartite motif containing 33provided by HGNC Primary source HGNC:HGNC:16290 See related Ensembl:ENSG00000197323 MIM:605769; AllianceGenome:HGNC:16290 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA Summary The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues See more Orthologs mouse all
TRIM34, Official Symbol TRIM34provided by HGNC Official Full Name tripartite motif containing 34provided by HGNC Primary source HGNC:HGNC:10063 See related Ensembl:ENSG00000258659 MIM:605684; AllianceGenome:HGNC:10063 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IFP1; RNF21 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in spleen (RPKM 7.4), lymph node (RPKM 6.3) and 24 other tissues See more Orthologs all
TRIM35, Official Symbol TRIM35provided by HGNC Official Full Name tripartite motif containing 35provided by HGNC Primary source HGNC:HGNC:16285 See related Ensembl:ENSG00000104228 MIM:617007; AllianceGenome:HGNC:16285 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLS5; MAIR Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 5.7), testis (RPKM 5.1) and 25 other tissues See more Orthologs mouse all
TRIM36, Official Symbol TRIM36provided by HGNC Official Full Name tripartite motif containing 36provided by HGNC Primary source HGNC:HGNC:16280 See related Ensembl:ENSG00000152503 MIM:609317; AllianceGenome:HGNC:16280 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ANPH; ANPH1; RNF98; HAPRIN; RBCC728 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues See more Orthologs mouse all
TRIM37, Official Symbol TRIM37provided by HGNC Official Full Name tripartite motif containing 37provided by HGNC Primary source HGNC:HGNC:7523 See related Ensembl:ENSG00000108395 MIM:605073; AllianceGenome:HGNC:7523 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MUL; POB1; TEF3 Summary This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020] Expression Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues See more Orthologs mouse all
TRIM38, Official Symbol TRIM38provided by HGNC Official Full Name tripartite motif containing 38provided by HGNC Primary source HGNC:HGNC:10059 See related Ensembl:ENSG00000112343 AllianceGenome:HGNC:10059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF15; RORET Summary This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in spleen (RPKM 9.0), lymph node (RPKM 8.4) and 24 other tissues See more Orthologs mouse all
TRIM39, Official Symbol TRIM39provided by HGNC Official Full Name tripartite motif containing 39provided by HGNC Primary source HGNC:HGNC:10065 See related Ensembl:ENSG00000204599 MIM:605700; AllianceGenome:HGNC:10065 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TFP; RNF23; TRIM39B Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
TRIM39-RPP21, Official Symbol TRIM39-RPP21provided by HGNC Official Full Name TRIM39-RPP21 readthroughprovided by HGNC Primary source HGNC:HGNC:38845 See related Ensembl:ENSG00000248167 AllianceGenome:HGNC:38845 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIM39R Summary This locus represents naturally occurring read-through transcription between the neighboring TRIM39 (tripartite motif-containing 39) and RPP21 (ribonuclease P/MRP 21kDa subunit) genes on chromosome 6. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in testis (RPKM 13.4), ovary (RPKM 7.8) and 25 other tissues See more Orthologs all
TRIM4, Official Symbol TRIM4provided by HGNC Official Full Name tripartite motif containing 4provided by HGNC Primary source HGNC:HGNC:16275 See related Ensembl:ENSG00000146833 AllianceGenome:HGNC:16275 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF87 Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010] Expression Ubiquitous expression in ovary (RPKM 16.5), thyroid (RPKM 12.9) and 25 other tissues See more Orthologs all
TRIM40, Official Symbol TRIM40provided by HGNC Official Full Name tripartite motif containing 40provided by HGNC Primary source HGNC:HGNC:18736 See related Ensembl:ENSG00000204614 MIM:616976; AllianceGenome:HGNC:18736 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF35 Summary This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014] Expression Biased expression in small intestine (RPKM 3.6), duodenum (RPKM 3.4) and 4 other tissues See more Orthologs mouse all
TRIM41, Official Symbol TRIM41provided by HGNC Official Full Name tripartite motif containing 41provided by HGNC Primary source HGNC:HGNC:19013 See related Ensembl:ENSG00000146063 MIM:610530; AllianceGenome:HGNC:19013 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RINCK Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in testis (RPKM 14.3), brain (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
TRIM42, Official Symbol TRIM42provided by HGNC Official Full Name tripartite motif containing 42provided by HGNC Primary source HGNC:HGNC:19014 See related Ensembl:ENSG00000155890 MIM:620334; AllianceGenome:HGNC:19014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T4A1; PPP1R40 Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 9.8) See more Orthologs mouse all
TRIM43, Official Symbol TRIM43provided by HGNC Official Full Name tripartite motif containing 43provided by HGNC Primary source HGNC:HGNC:19015 See related Ensembl:ENSG00000144015 AllianceGenome:HGNC:19015 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIM43A Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
TRIM43B, Official Symbol TRIM43Bprovided by HGNC Official Full Name tripartite motif containing 43Bprovided by HGNC Primary source HGNC:HGNC:37146 See related Ensembl:ENSG00000144010 AllianceGenome:HGNC:37146 Gene type protein coding RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
TRIM44, Official Symbol TRIM44provided by HGNC Official Full Name tripartite motif containing 44provided by HGNC Primary source HGNC:HGNC:19016 See related Ensembl:ENSG00000166326 MIM:612298; AllianceGenome:HGNC:19016 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AN3; MC7; DIPB; HSA249128 Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 26.6), thyroid (RPKM 23.0) and 25 other tissues See more Orthologs mouse all
TRIM45, Official Symbol TRIM45provided by HGNC Official Full Name tripartite motif containing 45provided by HGNC Primary source HGNC:HGNC:19018 See related Ensembl:ENSG00000134253 MIM:609318; AllianceGenome:HGNC:19018 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF99 Summary Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to act upstream of or within bone development. Located in cytosol; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 2.4), thyroid (RPKM 2.2) and 24 other tissues See more Orthologs mouse all
TRIM46, Official Symbol TRIM46provided by HGNC Official Full Name tripartite motif containing 46provided by HGNC Primary source HGNC:HGNC:19019 See related Ensembl:ENSG00000163462 MIM:600986; AllianceGenome:HGNC:19019 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GENEY; TRIFIC Summary This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of cancer cells including lung and breast cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s). Expression Broad expression in brain (RPKM 2.5), testis (RPKM 0.9) and 14 other tissues See more Orthologs mouse all
TRIM47, Official Symbol TRIM47provided by HGNC Official Full Name tripartite motif containing 47provided by HGNC Primary source HGNC:HGNC:19020 See related Ensembl:ENSG00000132481 MIM:611041; AllianceGenome:HGNC:19020 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GOA; RNF100 Summary Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 11.4), kidney (RPKM 8.9) and 24 other tissues See more Orthologs mouse all
TRIM48, Official Symbol TRIM48provided by HGNC Official Full Name tripartite motif containing 48provided by HGNC Primary source HGNC:HGNC:19021 See related Ensembl:ENSG00000150244 AllianceGenome:HGNC:19021 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF101 Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
TRIM49, Official Symbol TRIM49provided by HGNC Official Full Name tripartite motif containing 49provided by HGNC Primary source HGNC:HGNC:13431 See related Ensembl:ENSG00000168930 MIM:606124; AllianceGenome:HGNC:13431 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF18; TRIM49A; TRIM49L2 Summary The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010] Expression Low expression observed in reference dataset See more
TRIM49B, Official Symbol TRIM49Bprovided by HGNC Official Full Name tripartite motif containing 49Bprovided by HGNC Primary source HGNC:HGNC:42955 See related Ensembl:ENSG00000182053 AllianceGenome:HGNC:42955 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
TRIM49C, Official Symbol TRIM49Cprovided by HGNC Official Full Name tripartite motif containing 49Cprovided by HGNC Primary source HGNC:HGNC:38877 See related Ensembl:ENSG00000204449 AllianceGenome:HGNC:38877 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIM49L2 Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
TRIM49D1, Official Symbol TRIM49D1provided by HGNC Official Full Name tripartite motif containing 49D1provided by HGNC Primary source HGNC:HGNC:43973 See related Ensembl:ENSG00000223417 AllianceGenome:HGNC:43973 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIM49D; TRIM49D2; TRIM49DP; TRIM49D1P; TRIM49D2P Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
TRIM49D2, Official Symbol TRIM49D2provided by HGNC Official Full Name tripartite motif containing 49D2provided by HGNC Primary source HGNC:HGNC:37217 See related Ensembl:ENSG00000233802 AllianceGenome:HGNC:37217 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRIM49L; TRIM48L1; TRIM49D1; TRIM49L1; TRIM49D2P Summary Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
TRIM5, Official Symbol TRIM5provided by HGNC Official Full Name tripartite motif containing 5provided by HGNC Primary source HGNC:HGNC:16276 See related Ensembl:ENSG00000132256 MIM:608487; AllianceGenome:HGNC:16276 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RNF88; TRIM5alpha Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in urinary bladder (RPKM 5.4), endometrium (RPKM 5.4) and 25 other tissues See more Orthologs all