psui3905/ncbi_genes_summary huggingface dataset:
LAMTOR5-AS1, Official Symbol LAMTOR5-AS1provided by HGNC Official Full Name LAMTOR5 and SLC16A4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40823 See related Ensembl:ENSG00000224699 AllianceGenome:HGNC:40823 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in kidney (RPKM 28.6), testis (RPKM 11.7) and 16 other tissues See more
LANCL1, Official Symbol LANCL1provided by HGNC Official Full Name LanC like glutathione S-transferase 1provided by HGNC Primary source HGNC:HGNC:6508 See related Ensembl:ENSG00000115365 MIM:604155; AllianceGenome:HGNC:6508 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p40; GPR69A Summary This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in brain (RPKM 58.9), testis (RPKM 27.8) and 24 other tissues See more Orthologs mouse all
LANCL2, Official Symbol LANCL2provided by HGNC Official Full Name LanC like glutathione S-transferase 2provided by HGNC Primary source HGNC:HGNC:6509 See related Ensembl:ENSG00000132434 MIM:612919; AllianceGenome:HGNC:6509 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TASP; GPR69B Summary Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 16.9), testis (RPKM 9.1) and 24 other tissues See more Orthologs mouse all
LANCL3, Official Symbol LANCL3provided by HGNC Official Full Name LanC like family member 3provided by HGNC Primary source HGNC:HGNC:24767 See related Ensembl:ENSG00000147036 AllianceGenome:HGNC:24767 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in carbohydrate metabolic process. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
LAP3, Official Symbol LAP3provided by HGNC Official Full Name leucine aminopeptidase 3provided by HGNC Primary source HGNC:HGNC:18449 See related Ensembl:ENSG00000002549 MIM:170250; AllianceGenome:HGNC:18449 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAP; PEPS; LAPEP; HEL-S-106 Summary Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol; midbody; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in appendix (RPKM 73.5), lymph node (RPKM 68.4) and 24 other tissues See more Orthologs mouse all
LAP3P1, Official Symbol LAP3P1provided by HGNC Official Full Name leucine aminopeptidase 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:42364 See related Ensembl:ENSG00000220091 AllianceGenome:HGNC:42364 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LAP3P2, Official Symbol LAP3P2provided by HGNC Official Full Name leucine aminopeptidase 3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:42365 See related Ensembl:ENSG00000213500 AllianceGenome:HGNC:42365 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LAPTM4A, Official Symbol LAPTM4Aprovided by HGNC Official Full Name lysosomal protein transmembrane 4 alphaprovided by HGNC Primary source HGNC:HGNC:6924 See related Ensembl:ENSG00000068697 MIM:618837; AllianceGenome:HGNC:6924 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MBNT; Mtrp; LAPTM4; HUMORF13 Summary This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 245.2), testis (RPKM 209.5) and 25 other tissues See more Orthologs mouse all
LAPTM4A-DT, Official Symbol LAPTM4A-DTprovided by HGNC Official Full Name LAPTM4A divergent transcriptprovided by HGNC Primary source HGNC:HGNC:54382 See related AllianceGenome:HGNC:54382 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 1.5) and kidney (RPKM 0.2) See more
LAPTM4B, Official Symbol LAPTM4Bprovided by HGNC Official Full Name lysosomal protein transmembrane 4 betaprovided by HGNC Primary source HGNC:HGNC:13646 See related Ensembl:ENSG00000104341 MIM:613296; AllianceGenome:HGNC:13646 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LC27; LAPTM4beta Summary Enables ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 97.2), testis (RPKM 52.3) and 23 other tissues See more Orthologs mouse all
LAPTM4BP2, Official Symbol LAPTM4BP2provided by HGNC Official Full Name lysosomal protein transmembrane 4 beta pseudogene 2provided by HGNC Primary source HGNC:HGNC:51935 See related AllianceGenome:HGNC:51935 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LAPTM5, Official Symbol LAPTM5provided by HGNC Official Full Name lysosomal protein transmembrane 5provided by HGNC Primary source HGNC:HGNC:29612 See related Ensembl:ENSG00000162511 MIM:601476; AllianceGenome:HGNC:29612 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLAST6 Summary This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009] Expression Broad expression in bone marrow (RPKM 488.0), lymph node (RPKM 349.3) and 15 other tissues See more Orthologs mouse all
LARGE-AS1, Official Symbol LARGE-AS1provided by HGNC Official Full Name LARGE antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40336 See related Ensembl:ENSG00000224973 AllianceGenome:HGNC:40336 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 4.5) See more
LARGE1, Official Symbol LARGE1provided by HGNC Official Full Name LARGE xylosyl- and glucuronyltransferase 1provided by HGNC Primary source HGNC:HGNC:6511 See related Ensembl:ENSG00000133424 MIM:603590; AllianceGenome:HGNC:6511 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LARGE; MDC1D; MDDGA6; MDDGB6 Summary This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018] Expression Ubiquitous expression in brain (RPKM 9.1), heart (RPKM 8.9) and 23 other tissues See more Orthologs mouse all
LARGE2, Official Symbol LARGE2provided by HGNC Official Full Name LARGE xylosyl- and glucuronyltransferase 2provided by HGNC Primary source HGNC:HGNC:16522 See related Ensembl:ENSG00000165905 MIM:609709; AllianceGenome:HGNC:16522 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP5656; GYLTL1B Summary Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in placenta (RPKM 26.3), skin (RPKM 8.2) and 10 other tissues See more Orthologs mouse all
LARP1, Official Symbol LARP1provided by HGNC Official Full Name La ribonucleoprotein 1, translational regulatorprovided by HGNC Primary source HGNC:HGNC:29531 See related Ensembl:ENSG00000155506 MIM:612059; AllianceGenome:HGNC:29531 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LARP; Lar1; Lhp1 Summary Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Located in cytoplasmic stress granule. Colocalizes with TORC1 complex and polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.2) and 25 other tissues See more Orthologs mouse all
LARP1B, Official Symbol LARP1Bprovided by HGNC Official Full Name La ribonucleoprotein 1Bprovided by HGNC Primary source HGNC:HGNC:24704 See related Ensembl:ENSG00000138709 MIM:620467; AllianceGenome:HGNC:24704 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LARP2 Summary This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013] Expression Broad expression in testis (RPKM 13.1), liver (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
LARP1BP1, Official Symbol LARP1BP1provided by HGNC Official Full Name LARP1B pseudogene 1provided by HGNC Primary source HGNC:HGNC:37097 See related Ensembl:ENSG00000231442 AllianceGenome:HGNC:37097 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LARP1BP2, Official Symbol LARP1BP2provided by HGNC Official Full Name LARP1B pseudogene 2provided by HGNC Primary source HGNC:HGNC:44084 See related Ensembl:ENSG00000243438 AllianceGenome:HGNC:44084 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PBEF
LARP1BP3, Official Symbol LARP1BP3provided by HGNC Official Full Name LARP1B pseudogene 3provided by HGNC Primary source HGNC:HGNC:44085 See related AllianceGenome:HGNC:44085 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LARP1P1, Official Symbol LARP1P1provided by HGNC Official Full Name LARP1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:23183 See related AllianceGenome:HGNC:23183 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HCG10P; dJ221C16.7
LARP4, Official Symbol LARP4provided by HGNC Official Full Name La ribonucleoprotein 4provided by HGNC Primary source HGNC:HGNC:24320 See related Ensembl:ENSG00000161813 MIM:618657; AllianceGenome:HGNC:24320 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP13296 Summary Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytosol. Colocalizes with cytoplasmic stress granule; cytosolic small ribosomal subunit; and polysome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in liver (RPKM 13.3), adrenal (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
LARP4B, Official Symbol LARP4Bprovided by HGNC Official Full Name La ribonucleoprotein 4Bprovided by HGNC Primary source HGNC:HGNC:28987 See related Ensembl:ENSG00000107929 MIM:616513; AllianceGenome:HGNC:28987 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LARP5; KIAA0217 Summary This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in thyroid (RPKM 6.7), testis (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
LARP6, Official Symbol LARP6provided by HGNC Official Full Name La ribonucleoprotein 6, translational regulatorprovided by HGNC Primary source HGNC:HGNC:24012 See related Ensembl:ENSG00000166173 MIM:611300; AllianceGenome:HGNC:24012 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACHN Summary Enables RNA binding activity and myosin binding activity. Involved in positive regulation of collagen biosynthetic process; positive regulation of mRNA binding activity; and positive regulation of translation. Located in nucleus. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in brain (RPKM 22.8), thyroid (RPKM 15.1) and 17 other tissues See more Orthologs mouse all
LARP7, Official Symbol LARP7provided by HGNC Official Full Name La ribonucleoprotein 7, transcriptional regulatorprovided by HGNC Primary source HGNC:HGNC:24912 See related Ensembl:ENSG00000174720 MIM:612026; AllianceGenome:HGNC:24912 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALAZS; PIP7S; hLARP7; HDCMA18P Summary This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] Expression Ubiquitous expression in lymph node (RPKM 17.7), thyroid (RPKM 16.5) and 25 other tissues See more Orthologs mouse all
LARP7P1, Official Symbol LARP7P1provided by HGNC Official Full Name LARP7 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49763 See related Ensembl:ENSG00000271588 AllianceGenome:HGNC:49763 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LARP7P2, Official Symbol LARP7P2provided by HGNC Official Full Name LARP7 pseudogene 2provided by HGNC Primary source HGNC:HGNC:49764 See related Ensembl:ENSG00000261939 AllianceGenome:HGNC:49764 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LARP7P4, Official Symbol LARP7P4provided by HGNC Official Full Name LARP7 pseudogene 4provided by HGNC Primary source HGNC:HGNC:49766 See related Ensembl:ENSG00000244024 AllianceGenome:HGNC:49766 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LARS1, Official Symbol LARS1provided by HGNC Official Full Name leucyl-tRNA synthetase 1provided by HGNC Primary source HGNC:HGNC:6512 See related Ensembl:ENSG00000133706 MIM:151350; AllianceGenome:HGNC:6512 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRS; LARS; LEUS; LFIS; ILFS1; LEURS; PIG44; RNTLS; HSPC192; hr025Cl Summary This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in thyroid (RPKM 24.0), brain (RPKM 19.6) and 25 other tissues See more Orthologs mouse all
LARS2, Official Symbol LARS2provided by HGNC Official Full Name leucyl-tRNA synthetase 2, mitochondrialprovided by HGNC Primary source HGNC:HGNC:17095 See related Ensembl:ENSG00000011376 MIM:604544; AllianceGenome:HGNC:17095 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLASA; LEURS; PRLTS4; mtLeuRS Summary This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 6.2), brain (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
LAS1L, Official Symbol LAS1Lprovided by HGNC Official Full Name LAS1 like ribosome biogenesis factorprovided by HGNC Primary source HGNC:HGNC:25726 See related Ensembl:ENSG00000001497 MIM:300964; AllianceGenome:HGNC:25726 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WTS; Las1; MRXSWTS; Las1-like; dJ475B7.2 Summary Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 11.3), brain (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
LASP1, Official Symbol LASP1provided by HGNC Official Full Name LIM and SH3 protein 1provided by HGNC Primary source HGNC:HGNC:6513 See related Ensembl:ENSG00000002834 MIM:602920; AllianceGenome:HGNC:6513 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MLN50; Lasp-1 Summary This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in small intestine (RPKM 79.0), duodenum (RPKM 59.7) and 25 other tissues See more Orthologs mouse all
LASTR, Official Symbol LASTRprovided by HGNC Official Full Name lncRNA associated with SART3 regulation of splicingprovided by HGNC Primary source HGNC:HGNC:54143 See related Ensembl:ENSG00000242147 MIM:618938; AllianceGenome:HGNC:54143 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC02657 Expression Low expression observed in reference dataset See more
LAT, Official Symbol LATprovided by HGNC Official Full Name linker for activation of T cellsprovided by HGNC Primary source HGNC:HGNC:18874 See related Ensembl:ENSG00000213658 MIM:602354; AllianceGenome:HGNC:18874 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAT1; pp36; IMD52 Summary The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 29.3), appendix (RPKM 13.0) and 19 other tissues See more Orthologs mouse all
LAT2, Official Symbol LAT2provided by HGNC Official Full Name linker for activation of T cells family member 2provided by HGNC Primary source HGNC:HGNC:12749 See related Ensembl:ENSG00000086730 MIM:605719; AllianceGenome:HGNC:12749 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15 Summary This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008] Annotation information Note: LAT2 (Gene ID: 7462) and SLC7A8 (Gene ID: 23428) share the LAT2 symbol/alias in common. LAT2 is sometimes used as an alternative name for solute carrier family 7 member 8 (SLC7A8), which can be confused with the official symbol for linker for activation of T cells family member 2 (LAT2). [05 Jul 2018] Expression Broad expression in lymph node (RPKM 22.9), appendix (RPKM 20.3) and 16 other tissues See more Orthologs mouse all
LATS1, Official Symbol LATS1provided by HGNC Official Full Name large tumor suppressor kinase 1provided by HGNC Primary source HGNC:HGNC:6514 See related Ensembl:ENSG00000131023 MIM:603473; AllianceGenome:HGNC:6514 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as wts; WARTS Summary The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues See more Orthologs mouse all
LATS2, Official Symbol LATS2provided by HGNC Official Full Name large tumor suppressor kinase 2provided by HGNC Primary source HGNC:HGNC:6515 See related Ensembl:ENSG00000150457 MIM:604861; AllianceGenome:HGNC:6515 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KPM Summary This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
LAX1, Official Symbol LAX1provided by HGNC Official Full Name lymphocyte transmembrane adaptor 1provided by HGNC Primary source HGNC:HGNC:26005 See related Ensembl:ENSG00000122188 MIM:619622; AllianceGenome:HGNC:26005 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LAX Summary Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAP kinase activity; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 6.4), appendix (RPKM 5.1) and 13 other tissues See more Orthologs mouse all
LAYN, Official Symbol LAYNprovided by HGNC Official Full Name layilinprovided by HGNC Primary source HGNC:HGNC:29471 See related Ensembl:ENSG00000204381 MIM:618843; AllianceGenome:HGNC:29471 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables hyaluronic acid binding activity. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in ovary (RPKM 7.0), thyroid (RPKM 6.2) and 20 other tissues See more Orthologs mouse all
LBH, Official Symbol LBHprovided by HGNC Official Full Name LBH regulator of WNT signaling pathwayprovided by HGNC Primary source HGNC:HGNC:29532 See related Ensembl:ENSG00000213626 MIM:611763; AllianceGenome:HGNC:29532 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; and regulation of MAPK cascade. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lung (RPKM 81.1), lymph node (RPKM 54.3) and 23 other tissues See more Orthologs mouse all
LBHD1, Official Symbol LBHD1provided by HGNC Official Full Name LBH domain containing 1provided by HGNC Primary source HGNC:HGNC:28351 See related Ensembl:ENSG00000162194 AllianceGenome:HGNC:28351 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C11orf48 Summary This gene shares three exons in common with another gene, chromosome 11 open reading frame 98 (GeneID:102288414), but the encoded protein uses a reading frame that is different from that of the chromosome 11 open reading frame 98 gene. [provided by RefSeq, Nov 2017] Expression Ubiquitous expression in lymph node (RPKM 15.1), appendix (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
LBHD2, Official Symbol LBHD2provided by HGNC Official Full Name LBH domain containing 2provided by HGNC Primary source HGNC:HGNC:52384 See related Ensembl:ENSG00000283071 AllianceGenome:HGNC:52384 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more Orthologs mouse all
LBP, Official Symbol LBPprovided by HGNC Official Full Name lipopolysaccharide binding proteinprovided by HGNC Primary source HGNC:HGNC:6517 See related Ensembl:ENSG00000129988 MIM:151990; AllianceGenome:HGNC:6517 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BPIFD2 Summary The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012] Expression Restricted expression toward liver (RPKM 139.3) See more Orthologs mouse all
LBR, Official Symbol LBRprovided by HGNC Official Full Name lamin B receptorprovided by HGNC Primary source HGNC:HGNC:6518 See related Ensembl:ENSG00000143815 MIM:600024; AllianceGenome:HGNC:6518 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PHA; C14SR; LMN2R; PHASK; TDRD18; DHCR14B Summary The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 40.2), bone marrow (RPKM 33.5) and 23 other tissues See more Orthologs mouse all
LBX1, Official Symbol LBX1provided by HGNC Official Full Name ladybird homeobox 1provided by HGNC Primary source HGNC:HGNC:16960 See related Ensembl:ENSG00000138136 MIM:604255; AllianceGenome:HGNC:16960 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPX6; CCHS3; HPX-6; LBX1H; homeobox Summary This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
LBX2, Official Symbol LBX2provided by HGNC Official Full Name ladybird homeobox 2provided by HGNC Primary source HGNC:HGNC:15525 See related Ensembl:ENSG00000179528 MIM:607164; AllianceGenome:HGNC:15525 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LP3727 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including muscle cell differentiation; positive regulation of convergent extension involved in gastrulation; and positive regulation of non-canonical Wnt signaling pathway. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in liver (RPKM 2.5), small intestine (RPKM 1.7) and 11 other tissues See more Orthologs mouse all
LBX2-AS1, Official Symbol LBX2-AS1provided by HGNC Official Full Name LBX2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:25136 See related Ensembl:ENSG00000257702 AllianceGenome:HGNC:25136 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
LCA5, Official Symbol LCA5provided by HGNC Official Full Name lebercilin LCA5provided by HGNC Primary source HGNC:HGNC:31923 See related Ensembl:ENSG00000135338 MIM:611408; AllianceGenome:HGNC:31923 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C6orf152 Summary This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. [provided by RefSeq, Oct 2009] Expression Broad expression in testis (RPKM 5.0), thyroid (RPKM 4.0) and 25 other tissues See more Orthologs mouse all
LCA5L, Official Symbol LCA5Lprovided by HGNC Official Full Name lebercilin LCA5 likeprovided by HGNC Primary source HGNC:HGNC:1255 See related Ensembl:ENSG00000157578 AllianceGenome:HGNC:1255 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C21orf13 Summary Predicted to be involved in intraciliary transport. Predicted to be active in axoneme. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 36.4) See more Orthologs mouse all
LCAL1, Official Symbol LCAL1provided by HGNC Official Full Name lung cancer associated lncRNA 1provided by HGNC Primary source HGNC:HGNC:25837 See related Ensembl:ENSG00000286042 AllianceGenome:HGNC:25837 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as onco-lncRNA-27 Expression Low expression observed in reference dataset See more
LCAT, Official Symbol LCATprovided by HGNC Official Full Name lecithin-cholesterol acyltransferaseprovided by HGNC Primary source HGNC:HGNC:6522 See related Ensembl:ENSG00000213398 MIM:606967; AllianceGenome:HGNC:6522 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008] Expression Broad expression in liver (RPKM 51.1), skin (RPKM 11.1) and 19 other tissues See more Orthologs mouse all
LCE1A, Official Symbol LCE1Aprovided by HGNC Official Full Name late cornified envelope 1Aprovided by HGNC Primary source HGNC:HGNC:29459 See related Ensembl:ENSG00000186844 MIM:612603; AllianceGenome:HGNC:29459 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEP1 Summary LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below.[supplied by OMIM, Feb 2009] Orthologs all
LCE1B, Official Symbol LCE1Bprovided by HGNC Official Full Name late cornified envelope 1Bprovided by HGNC Primary source HGNC:HGNC:16611 See related Ensembl:ENSG00000196734 MIM:612604; AllianceGenome:HGNC:16611 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEP2; SPRL2A Summary Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
LCE1C, Official Symbol LCE1Cprovided by HGNC Official Full Name late cornified envelope 1Cprovided by HGNC Primary source HGNC:HGNC:29464 See related Ensembl:ENSG00000197084 MIM:612605; AllianceGenome:HGNC:29464 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEP3 Summary Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward skin (RPKM 108.0) See more Orthologs all
LCE1D, Official Symbol LCE1Dprovided by HGNC Official Full Name late cornified envelope 1Dprovided by HGNC Primary source HGNC:HGNC:29465 See related Ensembl:ENSG00000172155 MIM:612606; AllianceGenome:HGNC:29465 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEP4 Summary Enables identical protein binding activity. Involved in cognition. Acts upstream of or within cellular response to calcium ion. Located in cornified envelope and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward skin (RPKM 30.0) See more Orthologs all
LCE1E, Official Symbol LCE1Eprovided by HGNC Official Full Name late cornified envelope 1Eprovided by HGNC Primary source HGNC:HGNC:29466 See related Ensembl:ENSG00000186226 MIM:612607; AllianceGenome:HGNC:29466 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEP5 Summary Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward skin (RPKM 20.8) See more
LCE1F, Official Symbol LCE1Fprovided by HGNC Official Full Name late cornified envelope 1Fprovided by HGNC Primary source HGNC:HGNC:29467 See related Ensembl:ENSG00000240386 MIM:612608; AllianceGenome:HGNC:29467 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEP6 Summary Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
LCE2A, Official Symbol LCE2Aprovided by HGNC Official Full Name late cornified envelope 2Aprovided by HGNC Primary source HGNC:HGNC:29469 See related Ensembl:ENSG00000187173 MIM:612609; AllianceGenome:HGNC:29469 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LEP9 Summary Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward skin (RPKM 30.4) See more
LCE2B, Official Symbol LCE2Bprovided by HGNC Official Full Name late cornified envelope 2Bprovided by HGNC Primary source HGNC:HGNC:16610 See related Ensembl:ENSG00000159455 MIM:612610; AllianceGenome:HGNC:16610 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as XP5; LEP10; SPRL1B Summary This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. [provided by RefSeq, Jul 2008] Expression Restricted expression toward skin (RPKM 134.0) See more Orthologs all