psui3905/ncbi_genes_summary huggingface dataset:
TAPT1, Official Symbol TAPT1provided by HGNC Official Full Name transmembrane anterior posterior transformation 1provided by HGNC Primary source HGNC:HGNC:26887 See related Ensembl:ENSG00000169762 MIM:612758; AllianceGenome:HGNC:26887 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMVFR; OCLSBG Summary This gene encodes a highly conserved protein that localizes to the centrosome and/or ciliary basal body. Mutations in this gene disrupt Golgi morphology and trafficking and normal primary cilium formation and these mutations are congenitally manifested by severe undermineralization of the intra-uterine skeleton. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. In mouse, this gene is thought to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in bone marrow (RPKM 10.8), testis (RPKM 8.7) and 25 other tissues See more Orthologs mouse all
TAPT1-AS1, Official Symbol TAPT1-AS1provided by HGNC Official Full Name TAPT1 antisense RNA 1 (head to head)provided by HGNC Primary source HGNC:HGNC:26832 See related Ensembl:ENSG00000263327 AllianceGenome:HGNC:26832 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in skin (RPKM 2.1), colon (RPKM 1.8) and 25 other tissues See more
TARBP1, Official Symbol TARBP1provided by HGNC Official Full Name TAR (HIV-1) RNA binding protein 1provided by HGNC Primary source HGNC:HGNC:11568 See related Ensembl:ENSG00000059588 MIM:605052; AllianceGenome:HGNC:11568 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRM3; TRMT3; TRP185; TRP-185 Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 7.3), prostate (RPKM 6.2) and 25 other tissues See more Orthologs mouse all
TARBP2, Official Symbol TARBP2provided by HGNC Official Full Name TARBP2 subunit of RISC loading complexprovided by HGNC Primary source HGNC:HGNC:11569 See related Ensembl:ENSG00000139546 MIM:605053; AllianceGenome:HGNC:11569 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOQS; TRBP; TRBP1; TRBP2 Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 7.8), testis (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
TARDBP, Official Symbol TARDBPprovided by HGNC Official Full Name TAR DNA binding proteinprovided by HGNC Primary source HGNC:HGNC:11571 See related Ensembl:ENSG00000120948 MIM:605078; AllianceGenome:HGNC:11571 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALS10; TDP-43 Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 32.8), appendix (RPKM 30.2) and 25 other tissues See more Orthologs mouse all
TARDBPP2, Official Symbol TARDBPP2provided by HGNC Official Full Name TARDBP pseudogene 2provided by HGNC Primary source HGNC:HGNC:39848 See related Ensembl:ENSG00000238213 AllianceGenome:HGNC:39848 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TARID, Official Symbol TARIDprovided by HGNC Official Full Name TCF21 antisense RNA inducing promoter demethylationprovided by HGNC Primary source HGNC:HGNC:50506 See related Ensembl:ENSG00000227954 MIM:616058; AllianceGenome:HGNC:50506 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EYA4-AS1 Expression Broad expression in placenta (RPKM 2.4), ovary (RPKM 2.4) and 16 other tissues See more
TARM1, Official Symbol TARM1provided by HGNC Official Full Name T cell-interacting, activating receptor on myeloid cells 1provided by HGNC Primary source HGNC:HGNC:37250 See related Ensembl:ENSG00000248385 MIM:616802; AllianceGenome:HGNC:37250 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OLT-2 Summary Enables immunoglobulin receptor binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward bone marrow (RPKM 2.5) See more Orthologs mouse all
TARS1, Official Symbol TARS1provided by HGNC Official Full Name threonyl-tRNA synthetase 1provided by HGNC Primary source HGNC:HGNC:11572 See related Ensembl:ENSG00000113407 MIM:187790; AllianceGenome:HGNC:11572 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TARS; TTD7; ThrRS Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 23.8), esophagus (RPKM 20.5) and 25 other tissues See more Orthologs mouse all
TARS2, Official Symbol TARS2provided by HGNC Official Full Name threonyl-tRNA synthetase 2, mitochondrialprovided by HGNC Primary source HGNC:HGNC:30740 See related Ensembl:ENSG00000143374 MIM:612805; AllianceGenome:HGNC:30740 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as thrRS; TARSL1; COXPD21 Summary This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in kidney (RPKM 7.6), heart (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
TARS2P1, Official Symbol TARS2P1provided by HGNC Official Full Name TARS2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:43712 See related Ensembl:ENSG00000248104 AllianceGenome:HGNC:43712 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TARS3, Official Symbol TARS3provided by HGNC Official Full Name threonyl-tRNA synthetase 3provided by HGNC Primary source HGNC:HGNC:24728 See related Ensembl:ENSG00000185418 AllianceGenome:HGNC:24728 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TARSL2; ThrRS-L Summary Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
TAS1R1, Official Symbol TAS1R1provided by HGNC Official Full Name taste 1 receptor member 1provided by HGNC Primary source HGNC:HGNC:14448 See related Ensembl:ENSG00000173662 MIM:606225; AllianceGenome:HGNC:14448 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TR1; T1R1; GM148; GPR70 Summary The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Expression Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues See more Orthologs mouse all
TAS1R2, Official Symbol TAS1R2provided by HGNC Official Full Name taste 1 receptor member 2provided by HGNC Primary source HGNC:HGNC:14905 See related Ensembl:ENSG00000179002 MIM:606226; AllianceGenome:HGNC:14905 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TR2; T1R2; GPR71 Summary Contributes to sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet taste receptor complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
TAS1R3, Official Symbol TAS1R3provided by HGNC Official Full Name taste 1 receptor member 3provided by HGNC Primary source HGNC:HGNC:15661 See related Ensembl:ENSG00000169962 MIM:605865; AllianceGenome:HGNC:15661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T1R3 Summary The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015] Expression Broad expression in salivary gland (RPKM 1.8), duodenum (RPKM 0.7) and 22 other tissues See more Orthologs mouse all
TAS2R1, Official Symbol TAS2R1provided by HGNC Official Full Name taste 2 receptor member 1provided by HGNC Primary source HGNC:HGNC:14909 See related Ensembl:ENSG00000169777 MIM:604796; AllianceGenome:HGNC:14909 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R1; TRB7 Summary This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008] Orthologs mouse all
TAS2R10, Official Symbol TAS2R10provided by HGNC Official Full Name taste 2 receptor member 10provided by HGNC Primary source HGNC:HGNC:14918 See related Ensembl:ENSG00000121318 MIM:604791; AllianceGenome:HGNC:14918 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRB2; T2R10 Summary This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] Orthologs all
TAS2R13, Official Symbol TAS2R13provided by HGNC Official Full Name taste 2 receptor member 13provided by HGNC Primary source HGNC:HGNC:14919 See related Ensembl:ENSG00000212128 MIM:604792; AllianceGenome:HGNC:14919 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRB3; T2R13 Summary This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] Orthologs all
TAS2R14, Official Symbol TAS2R14provided by HGNC Official Full Name taste 2 receptor member 14provided by HGNC Primary source HGNC:HGNC:14920 See related Ensembl:ENSG00000212127 MIM:604790; AllianceGenome:HGNC:14920 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRB1; T2R14 Summary This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] Orthologs all
TAS2R16, Official Symbol TAS2R16provided by HGNC Official Full Name taste 2 receptor member 16provided by HGNC Primary source HGNC:HGNC:14921 See related Ensembl:ENSG00000128519 MIM:604867; AllianceGenome:HGNC:14921 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BGLPT; T2R16 Summary This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] Orthologs mouse all
TAS2R19, Official Symbol TAS2R19provided by HGNC Official Full Name taste 2 receptor member 19provided by HGNC Primary source HGNC:HGNC:19108 See related Ensembl:ENSG00000212124 MIM:613961; AllianceGenome:HGNC:19108 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R19; T2R23; T2R48; MSTP058; TAS2R23; TAS2R48 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of taste. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
TAS2R20, Official Symbol TAS2R20provided by HGNC Official Full Name taste 2 receptor member 20provided by HGNC Primary source HGNC:HGNC:19109 See related Ensembl:ENSG00000255837 MIM:613962; AllianceGenome:HGNC:19109 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R20; T2R49; T2R56; TAS2R49 Summary This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016] Orthologs all
TAS2R2P, Official Symbol TAS2R2Pprovided by HGNC Official Full Name taste 2 receptor member 2, pseudogeneprovided by HGNC Primary source HGNC:HGNC:20615 See related Ensembl:ENSG00000203523 AllianceGenome:HGNC:20615 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PS9; T2R2; T2R02; TAS2R2
TAS2R3, Official Symbol TAS2R3provided by HGNC Official Full Name taste 2 receptor member 3provided by HGNC Primary source HGNC:HGNC:14910 See related Ensembl:ENSG00000127362 MIM:604868; AllianceGenome:HGNC:14910 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R3 Summary This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] Orthologs mouse all
TAS2R30, Official Symbol TAS2R30provided by HGNC Official Full Name taste 2 receptor member 30provided by HGNC Primary source HGNC:HGNC:19112 See related Ensembl:ENSG00000256188 MIM:613963; AllianceGenome:HGNC:19112 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R30; T2R47; TAS2R47 Summary Enables bitter taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
TAS2R31, Official Symbol TAS2R31provided by HGNC Official Full Name taste 2 receptor member 31provided by HGNC Primary source HGNC:HGNC:19113 See related Ensembl:ENSG00000256436 MIM:612669; AllianceGenome:HGNC:19113 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R31; T2R44; T2R53; TAS2R44 Summary TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]
TAS2R38, Official Symbol TAS2R38provided by HGNC Official Full Name taste 2 receptor member 38provided by HGNC Primary source HGNC:HGNC:9584 See related Ensembl:ENSG00000257138 MIM:607751; AllianceGenome:HGNC:9584 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTC; T2R38; T2R61; THIOT Summary This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009] Orthologs mouse all
TAS2R39, Official Symbol TAS2R39provided by HGNC Official Full Name taste 2 receptor member 39provided by HGNC Primary source HGNC:HGNC:18886 See related Ensembl:ENSG00000236398 AllianceGenome:HGNC:18886 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R39; T2R57 Summary The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015] Orthologs mouse all
TAS2R4, Official Symbol TAS2R4provided by HGNC Official Full Name taste 2 receptor member 4provided by HGNC Primary source HGNC:HGNC:14911 See related Ensembl:ENSG00000127364 MIM:604869; AllianceGenome:HGNC:14911 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R4 Summary This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] Orthologs mouse all
TAS2R40, Official Symbol TAS2R40provided by HGNC Official Full Name taste 2 receptor member 40provided by HGNC Primary source HGNC:HGNC:18885 See related Ensembl:ENSG00000221937 MIM:613964; AllianceGenome:HGNC:18885 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR60; T2R40; T2R58 Summary This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017] Orthologs mouse all
TAS2R41, Official Symbol TAS2R41provided by HGNC Official Full Name taste 2 receptor member 41provided by HGNC Primary source HGNC:HGNC:18883 See related Ensembl:ENSG00000221855 MIM:613965; AllianceGenome:HGNC:18883 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R41; T2R59 Summary This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. Chloramphenicol is an agonist for the encoded protein. [provided by RefSeq, Jul 2017] Orthologs all
TAS2R42, Official Symbol TAS2R42provided by HGNC Official Full Name taste 2 receptor member 42provided by HGNC Primary source HGNC:HGNC:18888 See related Ensembl:ENSG00000186136 MIM:613966; AllianceGenome:HGNC:18888 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R24; T2R42; T2R55; TAS2R55 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of taste. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
TAS2R43, Official Symbol TAS2R43provided by HGNC Official Full Name taste 2 receptor member 43provided by HGNC Primary source HGNC:HGNC:18875 See related Ensembl:ENSG00000255374 MIM:612668; AllianceGenome:HGNC:18875 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R43; T2R52 Summary TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]
TAS2R46, Official Symbol TAS2R46provided by HGNC Official Full Name taste 2 receptor member 46provided by HGNC Primary source HGNC:HGNC:18877 See related Ensembl:ENSG00000226761 MIM:612774; AllianceGenome:HGNC:18877 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R46; T2R54 Summary TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
TAS2R5, Official Symbol TAS2R5provided by HGNC Official Full Name taste 2 receptor member 5provided by HGNC Primary source HGNC:HGNC:14912 See related Ensembl:ENSG00000127366 MIM:605062; AllianceGenome:HGNC:14912 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R5 Summary This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] Orthologs all
TAS2R50, Official Symbol TAS2R50provided by HGNC Official Full Name taste 2 receptor member 50provided by HGNC Primary source HGNC:HGNC:18882 See related Ensembl:ENSG00000212126 MIM:609627; AllianceGenome:HGNC:18882 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R50; T2R51; TAS2R51 Summary TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008] Orthologs all
TAS2R60, Official Symbol TAS2R60provided by HGNC Official Full Name taste 2 receptor member 60provided by HGNC Primary source HGNC:HGNC:20639 See related Ensembl:ENSG00000185899 MIM:613968; AllianceGenome:HGNC:20639 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R56; T2R60 Summary This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. [provided by RefSeq, Jul 2017] Orthologs mouse all
TAS2R64P, Official Symbol TAS2R64Pprovided by HGNC Official Full Name taste 2 receptor member 64 pseudogeneprovided by HGNC Primary source HGNC:HGNC:20642 See related Ensembl:ENSG00000256274 AllianceGenome:HGNC:20642 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PS2; T2R64; T2R64P
TAS2R6P, Official Symbol TAS2R6Pprovided by HGNC Official Full Name taste 2 receptor member 6 pseudogeneprovided by HGNC Primary source HGNC:HGNC:20616 See related Ensembl:ENSG00000270923 AllianceGenome:HGNC:20616 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PS3; T2R6; T2R06; TAS2R6
TAS2R7, Official Symbol TAS2R7provided by HGNC Official Full Name taste 2 receptor member 7provided by HGNC Primary source HGNC:HGNC:14913 See related Ensembl:ENSG00000121377 MIM:604793; AllianceGenome:HGNC:14913 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R7; TRB4 Summary This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] Orthologs all
TAS2R8, Official Symbol TAS2R8provided by HGNC Official Full Name taste 2 receptor member 8provided by HGNC Primary source HGNC:HGNC:14915 See related Ensembl:ENSG00000121314 MIM:604794; AllianceGenome:HGNC:14915 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R8; TRB5 Summary This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] Orthologs all
TAS2R9, Official Symbol TAS2R9provided by HGNC Official Full Name taste 2 receptor member 9provided by HGNC Primary source HGNC:HGNC:14917 See related Ensembl:ENSG00000121381 MIM:604795; AllianceGenome:HGNC:14917 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T2R9; TRB6 Summary This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] Orthologs all
TASL, Official Symbol TASLprovided by HGNC Official Full Name TLR adaptor interacting with endolysosomal SLC15A4provided by HGNC Primary source HGNC:HGNC:25667 See related Ensembl:ENSG00000120280 MIM:301049; AllianceGenome:HGNC:25667 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXorf21 Summary Involved in positive regulation of innate immune response; positive regulation of toll-like receptor signaling pathway; and regulation of lysosomal lumen pH. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 6.2) and 17 other tissues See more Orthologs mouse all
TASOR, Official Symbol TASORprovided by HGNC Official Full Name transcription activation suppressorprovided by HGNC Primary source HGNC:HGNC:30314 See related Ensembl:ENSG00000163946 MIM:616493; AllianceGenome:HGNC:30314 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAP140; TASOR1; se89-1; C3orf63; FAM208A Summary Enables chromatin binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; protein localization to heterochromatin; and regulation of gene expression. Located in heterochromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 15.9), lymph node (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
TASOR2, Official Symbol TASOR2provided by HGNC Official Full Name transcription activation suppressor family member 2provided by HGNC Primary source HGNC:HGNC:23484 See related Ensembl:ENSG00000108021 AllianceGenome:HGNC:23484 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM208B; C10orf18; bA318E3.2 Summary Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 5.1) and 25 other tissues See more Orthologs mouse all
TASP1, Official Symbol TASP1provided by HGNC Official Full Name taspase 1provided by HGNC Primary source HGNC:HGNC:15859 See related Ensembl:ENSG00000089123 MIM:608270; AllianceGenome:HGNC:15859 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SULEHS; C20orf13; dJ585I14.2 Summary This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 2.9), testis (RPKM 2.2) and 25 other tissues See more Orthologs mouse all
TAT-AS1, Official Symbol TAT-AS1provided by HGNC Official Full Name TAT antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51369 See related Ensembl:ENSG00000260886 AllianceGenome:HGNC:51369 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward liver (RPKM 104.4) See more
TATDN1, Official Symbol TATDN1provided by HGNC Official Full Name TatD DNase domain containing 1provided by HGNC Primary source HGNC:HGNC:24220 See related Ensembl:ENSG00000147687 MIM:619364; AllianceGenome:HGNC:24220 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDA11 Summary Predicted to enable 3'-5'-exodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process and nucleic acid phosphodiester bond hydrolysis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 16.0), ovary (RPKM 13.3) and 25 other tissues See more Orthologs mouse all
TATDN1P1, Official Symbol TATDN1P1provided by HGNC Official Full Name TatD DNase domain containing 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:45058 See related Ensembl:ENSG00000234369 AllianceGenome:HGNC:45058 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TATDN2, Official Symbol TATDN2provided by HGNC Official Full Name TatD DNase domain containing 2provided by HGNC Primary source HGNC:HGNC:28988 See related Ensembl:ENSG00000157014 MIM:619330; AllianceGenome:HGNC:28988 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity and nuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 17.8), lymph node (RPKM 17.6) and 25 other tissues See more Orthologs mouse all
TATDN2P1, Official Symbol TATDN2P1provided by HGNC Official Full Name TatD DNase domain containing 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39254 See related Ensembl:ENSG00000198414 AllianceGenome:HGNC:39254 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TATDN2P2, Official Symbol TATDN2P2provided by HGNC Official Full Name TatD DNase domain containing 2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:39255 See related AllianceGenome:HGNC:39255 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TATDN3, Official Symbol TATDN3provided by HGNC Official Full Name TatD DNase domain containing 3provided by HGNC Primary source HGNC:HGNC:27010 See related Ensembl:ENSG00000203705 AllianceGenome:HGNC:27010 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable metal ion binding activity and nuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 5.5), fat (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
TAX1BP1, Official Symbol TAX1BP1provided by HGNC Official Full Name Tax1 binding protein 1provided by HGNC Primary source HGNC:HGNC:11575 See related Ensembl:ENSG00000106052 MIM:605326; AllianceGenome:HGNC:11575 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T6BP; TXBP151; CALCOCO3 Summary This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] Expression Ubiquitous expression in adrenal (RPKM 48.4), thyroid (RPKM 48.2) and 25 other tissues See more Orthologs mouse all
TAX1BP1-AS1, Official Symbol TAX1BP1-AS1provided by HGNC Official Full Name TAX1BP1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40576 See related AllianceGenome:HGNC:40576 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more