psui3905/ncbi_genes_summary huggingface dataset:
KCNAB1-AS1, Official Symbol KCNAB1-AS1provided by HGNC Official Full Name KCNAB1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40316 See related Ensembl:ENSG00000242370 AllianceGenome:HGNC:40316 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
KCNAB1-AS2, Official Symbol KCNAB1-AS2provided by HGNC Official Full Name KCNAB1 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40315 See related Ensembl:ENSG00000240596 AllianceGenome:HGNC:40315 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
KCNAB2, Official Symbol KCNAB2provided by HGNC Official Full Name potassium voltage-gated channel subfamily A regulatory beta subunit 2provided by HGNC Primary source HGNC:HGNC:6229 See related Ensembl:ENSG00000069424 MIM:601142; AllianceGenome:HGNC:6229 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AKR6A5; KCNA2B; HKvbeta2; KV-BETA-2; HKvbeta2.1; HKvbeta2.2 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010] Expression Broad expression in brain (RPKM 17.0), bone marrow (RPKM 11.9) and 17 other tissues See more Orthologs mouse all
KCNAB3, Official Symbol KCNAB3provided by HGNC Official Full Name potassium voltage-gated channel subfamily A regulatory beta subunit 3provided by HGNC Primary source HGNC:HGNC:6230 See related Ensembl:ENSG00000170049 MIM:604111; AllianceGenome:HGNC:6230 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AKR6A9; KCNA3B; KCNA3.1B; KV-BETA-3 Summary This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012] Expression Broad expression in endometrium (RPKM 5.0), brain (RPKM 1.9) and 18 other tissues See more Orthologs mouse all
KCNB1, Official Symbol KCNB1provided by HGNC Official Full Name potassium voltage-gated channel subfamily B member 1provided by HGNC Primary source HGNC:HGNC:6231 See related Ensembl:ENSG00000158445 MIM:600397; AllianceGenome:HGNC:6231 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRK1; DEE26; Kv2.1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 9.2), fat (RPKM 8.5) and 6 other tissues See more Orthologs mouse all
KCNB2, Official Symbol KCNB2provided by HGNC Official Full Name potassium voltage-gated channel subfamily B member 2provided by HGNC Primary source HGNC:HGNC:6232 See related Ensembl:ENSG00000182674 MIM:607738; AllianceGenome:HGNC:6232 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV2.2 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
KCNC1, Official Symbol KCNC1provided by HGNC Official Full Name potassium voltage-gated channel subfamily C member 1provided by HGNC Primary source HGNC:HGNC:6233 See related Ensembl:ENSG00000129159 MIM:176258; AllianceGenome:HGNC:6233 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV4; EPM7; NGK2; KV3.1 Summary This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014] Expression Biased expression in brain (RPKM 5.1) and testis (RPKM 0.7) See more Orthologs mouse all
KCNC2, Official Symbol KCNC2provided by HGNC Official Full Name potassium voltage-gated channel subfamily C member 2provided by HGNC Primary source HGNC:HGNC:6234 See related Ensembl:ENSG00000166006 MIM:176256; AllianceGenome:HGNC:6234 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV3.2; DEE103 Summary The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] Expression Restricted expression toward brain (RPKM 14.9) See more Orthologs mouse all
KCNC3, Official Symbol KCNC3provided by HGNC Official Full Name potassium voltage-gated channel subfamily C member 3provided by HGNC Primary source HGNC:HGNC:6235 See related Ensembl:ENSG00000131398 MIM:176264; AllianceGenome:HGNC:6235 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV3.3; SCA13; KSHIIID Summary The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014] Expression Broad expression in brain (RPKM 4.9), kidney (RPKM 2.9) and 17 other tissues See more Orthologs mouse all
KCNC4, Official Symbol KCNC4provided by HGNC Official Full Name potassium voltage-gated channel subfamily C member 4provided by HGNC Primary source HGNC:HGNC:6236 See related Ensembl:ENSG00000116396 MIM:176265; AllianceGenome:HGNC:6236 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV3.4; C1orf30; KSHIIIC; HKSHIIIC Summary The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in brain (RPKM 4.0), kidney (RPKM 3.0) and 24 other tissues See more Orthologs mouse all
KCND1, Official Symbol KCND1provided by HGNC Official Full Name potassium voltage-gated channel subfamily D member 1provided by HGNC Primary source HGNC:HGNC:6237 See related Ensembl:ENSG00000102057 MIM:300281; AllianceGenome:HGNC:6237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV4.1 Summary This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in gall bladder (RPKM 1.4), brain (RPKM 1.1) and 24 other tissues See more Orthologs mouse all
KCND2, Official Symbol KCND2provided by HGNC Official Full Name potassium voltage-gated channel subfamily D member 2provided by HGNC Primary source HGNC:HGNC:6238 See related Ensembl:ENSG00000184408 MIM:605410; AllianceGenome:HGNC:6238 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RK5; KV4.2 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.5), endometrium (RPKM 1.1) and 5 other tissues See more Orthologs mouse all
KCND3, Official Symbol KCND3provided by HGNC Official Full Name potassium voltage-gated channel subfamily D member 3provided by HGNC Primary source HGNC:HGNC:6239 See related Ensembl:ENSG00000171385 MIM:605411; AllianceGenome:HGNC:6239 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 4.9), prostate (RPKM 2.7) and 17 other tissues See more Orthologs mouse all
KCND3-AS1, Official Symbol KCND3-AS1provided by HGNC Official Full Name KCND3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40317 See related Ensembl:ENSG00000237556 AllianceGenome:HGNC:40317 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.2) See more
KCND3-IT1, Official Symbol KCND3-IT1provided by HGNC Official Full Name KCND3 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41350 See related Ensembl:ENSG00000232558 AllianceGenome:HGNC:41350 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
KCNE1, Official Symbol KCNE1provided by HGNC Official Full Name potassium voltage-gated channel subfamily E regulatory subunit 1provided by HGNC Primary source HGNC:HGNC:6240 See related Ensembl:ENSG00000180509 MIM:176261; AllianceGenome:HGNC:6240 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ISK; JLNS; LQT5; MinK; JLNS2; LQT2/5 Summary The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 1.7), kidney (RPKM 1.5) and 7 other tissues See more Orthologs mouse all
KCNE2, Official Symbol KCNE2provided by HGNC Official Full Name potassium voltage-gated channel subfamily E regulatory subunit 2provided by HGNC Primary source HGNC:HGNC:6242 See related Ensembl:ENSG00000159197 MIM:603796; AllianceGenome:HGNC:6242 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LQT5; LQT6; ATFB4; MIRP1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008] Expression Biased expression in stomach (RPKM 72.9) and duodenum (RPKM 4.0) See more Orthologs mouse all
KCNE3, Official Symbol KCNE3provided by HGNC Official Full Name potassium voltage-gated channel subfamily E regulatory subunit 3provided by HGNC Primary source HGNC:HGNC:6243 See related Ensembl:ENSG00000175538 MIM:604433; AllianceGenome:HGNC:6243 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYPP; HOKPP; MiRP2; BRGDA6 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008] Expression Broad expression in duodenum (RPKM 10.8), stomach (RPKM 10.5) and 18 other tissues See more Orthologs mouse all
KCNE4, Official Symbol KCNE4provided by HGNC Official Full Name potassium voltage-gated channel subfamily E regulatory subunit 4provided by HGNC Primary source HGNC:HGNC:6244 See related Ensembl:ENSG00000152049 MIM:607775; AllianceGenome:HGNC:6244 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIRP3 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008] Expression Broad expression in endometrium (RPKM 17.0), gall bladder (RPKM 15.1) and 21 other tissues See more Orthologs mouse all
KCNE5, Official Symbol KCNE5provided by HGNC Official Full Name potassium voltage-gated channel subfamily E regulatory subunit 5provided by HGNC Primary source HGNC:HGNC:6241 See related Ensembl:ENSG00000176076 MIM:300328; AllianceGenome:HGNC:6241 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KCNE1L Summary This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016] Orthologs mouse all
KCNF1, Official Symbol KCNF1provided by HGNC Official Full Name potassium voltage-gated channel modifier subfamily F member 1provided by HGNC Primary source HGNC:HGNC:6246 See related Ensembl:ENSG00000162975 MIM:603787; AllianceGenome:HGNC:6246 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IK8; kH1; KCNF; KV5.1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008] Orthologs mouse all
KCNG1, Official Symbol KCNG1provided by HGNC Official Full Name potassium voltage-gated channel modifier subfamily G member 1provided by HGNC Primary source HGNC:HGNC:6248 See related Ensembl:ENSG00000026559 MIM:603788; AllianceGenome:HGNC:6248 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as K13; kH2; KCNG; KV6.1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008] Expression Biased expression in endometrium (RPKM 3.9), placenta (RPKM 2.0) and 11 other tissues See more Orthologs mouse all
KCNG2, Official Symbol KCNG2provided by HGNC Official Full Name potassium voltage-gated channel modifier subfamily G member 2provided by HGNC Primary source HGNC:HGNC:6249 See related Ensembl:ENSG00000178342 MIM:605696; AllianceGenome:HGNC:6249 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KCNF2; KV6.2 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
KCNG3, Official Symbol KCNG3provided by HGNC Official Full Name potassium voltage-gated channel modifier subfamily G member 3provided by HGNC Primary source HGNC:HGNC:18306 See related Ensembl:ENSG00000171126 MIM:606767; AllianceGenome:HGNC:18306 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV6.3; KV10.1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
KCNG4, Official Symbol KCNG4provided by HGNC Official Full Name potassium voltage-gated channel modifier subfamily G member 4provided by HGNC Primary source HGNC:HGNC:19697 See related Ensembl:ENSG00000168418 MIM:607603; AllianceGenome:HGNC:19697 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KV6.3; KV6.4 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
KCNH1, Official Symbol KCNH1provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 1provided by HGNC Primary source HGNC:HGNC:6250 See related Ensembl:ENSG00000143473 MIM:603305; AllianceGenome:HGNC:6250 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAG; EAG1; ZLS1; hEAG; TMBTS; h-eag; hEAG1; Kv10.1; K(V)10.1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.3), adrenal (RPKM 0.4) and 3 other tissues See more Orthologs mouse all
KCNH1-IT1, Official Symbol KCNH1-IT1provided by HGNC Official Full Name KCNH1 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41351 See related AllianceGenome:HGNC:41351 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
KCNH2, Official Symbol KCNH2provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 2provided by HGNC Primary source HGNC:HGNC:6251 See related Ensembl:ENSG00000055118 MIM:152427; AllianceGenome:HGNC:6251 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERG1; HERG; LQT2; SQT1; ERG-1; H-ERG; HERG1; Kv11.1 Summary This gene encodes a component of a voltage-activated potassium channel found in cardiac muscle, nerve cells, and microglia. Four copies of this protein interact with one copy of the KCNE2 protein to form a functional potassium channel. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, May 2022] Expression Broad expression in bone marrow (RPKM 13.5), testis (RPKM 10.7) and 14 other tissues See more Orthologs mouse all
KCNH3, Official Symbol KCNH3provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 3provided by HGNC Primary source HGNC:HGNC:6252 See related Ensembl:ENSG00000135519 MIM:604527; AllianceGenome:HGNC:6252 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BEC1; ELK2; Kv12.2 Summary The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] Expression Biased expression in brain (RPKM 7.0), testis (RPKM 0.9) and 2 other tissues See more Orthologs mouse all
KCNH4, Official Symbol KCNH4provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 4provided by HGNC Primary source HGNC:HGNC:6253 See related Ensembl:ENSG00000089558 MIM:604528; AllianceGenome:HGNC:6253 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BEC2; ELK1; Kv12.3 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
KCNH5, Official Symbol KCNH5provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 5provided by HGNC Primary source HGNC:HGNC:6254 See related Ensembl:ENSG00000140015 MIM:605716; AllianceGenome:HGNC:6254 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EAG2; hEAG2; H-EAG2; Kv10.2 Summary This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Biased expression in brain (RPKM 1.4), adrenal (RPKM 0.6) and 2 other tissues See more Orthologs mouse all
KCNH6, Official Symbol KCNH6provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 6provided by HGNC Primary source HGNC:HGNC:18862 See related Ensembl:ENSG00000173826 MIM:608168; AllianceGenome:HGNC:18862 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERG2; ERG-2; HERG2; Kv11.2; hERG-2 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] Expression Biased expression in kidney (RPKM 3.1), small intestine (RPKM 1.8) and 4 other tissues See more Orthologs mouse all
KCNH7, Official Symbol KCNH7provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 7provided by HGNC Primary source HGNC:HGNC:18863 See related Ensembl:ENSG00000184611 MIM:608169; AllianceGenome:HGNC:18863 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERG3; HERG3; Kv11.3 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 1.6), testis (RPKM 0.5) and 3 other tissues See more Orthologs mouse all
KCNH7-AS1, Official Symbol KCNH7-AS1provided by HGNC Official Full Name KCNH7 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40858 See related Ensembl:ENSG00000237750 AllianceGenome:HGNC:40858 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 1.0) See more
KCNH8, Official Symbol KCNH8provided by HGNC Official Full Name potassium voltage-gated channel subfamily H member 8provided by HGNC Primary source HGNC:HGNC:18864 See related Ensembl:ENSG00000183960 MIM:608260; AllianceGenome:HGNC:18864 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ELK; ELK1; elk3; Kv12.1 Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.2), adrenal (RPKM 1.5) and 13 other tissues See more Orthologs mouse all
KCNIP1, Official Symbol KCNIP1provided by HGNC Official Full Name potassium voltage-gated channel interacting protein 1provided by HGNC Primary source HGNC:HGNC:15521 See related Ensembl:ENSG00000182132 MIM:604660; AllianceGenome:HGNC:15521 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VABP; KCHIP1 Summary This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] Expression Biased expression in brain (RPKM 5.5), testis (RPKM 1.0) and 6 other tissues See more Orthologs mouse all
KCNIP1-AS1, Official Symbol KCNIP1-AS1provided by HGNC Official Full Name KCNIP1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40710 See related Ensembl:ENSG00000253591 AllianceGenome:HGNC:40710 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
KCNIP1-OT1, Official Symbol KCNIP1-OT1provided by HGNC Official Full Name KCNIP1 overlapping transcript 1provided by HGNC Primary source HGNC:HGNC:40320 See related Ensembl:ENSG00000253647 AllianceGenome:HGNC:40320 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTD-2270F17.1 Expression Broad expression in endometrium (RPKM 2.8), prostate (RPKM 2.7) and 14 other tissues See more
KCNIP2, Official Symbol KCNIP2provided by HGNC Official Full Name potassium voltage-gated channel interacting protein 2provided by HGNC Primary source HGNC:HGNC:15522 See related Ensembl:ENSG00000120049 MIM:604661; AllianceGenome:HGNC:15522 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KCHIP2 Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 117.8), heart (RPKM 37.5) and 1 other tissue See more Orthologs mouse all
KCNIP3, Official Symbol KCNIP3provided by HGNC Official Full Name potassium voltage-gated channel interacting protein 3provided by HGNC Primary source HGNC:HGNC:15523 See related Ensembl:ENSG00000115041 MIM:604662; AllianceGenome:HGNC:15523 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSEN; DREAM; KCHIP3 Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 13.6), thyroid (RPKM 9.3) and 14 other tissues See more Orthologs mouse all
KCNIP4, Official Symbol KCNIP4provided by HGNC Official Full Name potassium voltage-gated channel interacting protein 4provided by HGNC Primary source HGNC:HGNC:30083 See related Ensembl:ENSG00000185774 MIM:608182; AllianceGenome:HGNC:30083 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CALP; KCHIP4 Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 3.7), endometrium (RPKM 1.2) and 15 other tissues See more Orthologs mouse all
KCNIP4-IT1, Official Symbol KCNIP4-IT1provided by HGNC Official Full Name KCNIP4 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:29895 See related Ensembl:ENSG00000280650 AllianceGenome:HGNC:29895 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UM9-5; UM9(5); NCRNA00099
KCNJ1, Official Symbol KCNJ1provided by HGNC Official Full Name potassium inwardly rectifying channel subfamily J member 1provided by HGNC Primary source HGNC:HGNC:6255 See related Ensembl:ENSG00000151704 MIM:600359; AllianceGenome:HGNC:6255 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ROMK; ROMK1; KIR1.1 Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Restricted expression toward kidney (RPKM 75.2) See more Orthologs mouse all
KCNJ10, Official Symbol KCNJ10provided by HGNC Official Full Name potassium inwardly rectifying channel subfamily J member 10provided by HGNC Primary source HGNC:HGNC:6256 See related Ensembl:ENSG00000177807 MIM:602208; AllianceGenome:HGNC:6256 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN Summary This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 52.7), kidney (RPKM 14.4) and 2 other tissues See more Orthologs mouse all