psui3905/ncbi_genes_summary huggingface dataset:
UBE2D3, Official Symbol UBE2D3provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 D3provided by HGNC Primary source HGNC:HGNC:12476 See related Ensembl:ENSG00000109332 MIM:602963; AllianceGenome:HGNC:12476 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC4/5; UBCH5C; E2(17)KB3 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017] Expression Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues See more Orthologs mouse all
UBE2D3P1, Official Symbol UBE2D3P1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 D3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:33349 See related AllianceGenome:HGNC:33349 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBE2D3L; UBE2D3P; UBE2D5P; RP4-680N4
UBE2D3P3, Official Symbol UBE2D3P3provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 D3 pseudogene 3provided by HGNC Primary source HGNC:HGNC:39011 See related Ensembl:ENSG00000224690 AllianceGenome:HGNC:39011 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2D3P4, Official Symbol UBE2D3P4provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 D3 pseudogene 4provided by HGNC Primary source HGNC:HGNC:39391 See related AllianceGenome:HGNC:39391 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2D4, Official Symbol UBE2D4provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 D4 (putative)provided by HGNC Primary source HGNC:HGNC:21647 See related Ensembl:ENSG00000078967 AllianceGenome:HGNC:21647 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBUCE1 Summary Enables ubiquitin conjugating enzyme activity. Involved in protein polyubiquitination. Acts upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 5.7) and 25 other tissues See more Orthologs all
UBE2DNL, Official Symbol UBE2DNLprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 D N-terminal like (pseudogene)provided by HGNC Primary source HGNC:HGNC:28656 See related Ensembl:ENSG00000229547 AllianceGenome:HGNC:28656 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic metaphase/anaphase transition. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
UBE2E1, Official Symbol UBE2E1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 E1provided by HGNC Primary source HGNC:HGNC:12477 See related Ensembl:ENSG00000170142 MIM:602916; AllianceGenome:HGNC:12477 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBCH6 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in lymph node (RPKM 26.5), brain (RPKM 25.3) and 25 other tissues See more Orthologs all
UBE2E1-AS1, Official Symbol UBE2E1-AS1provided by HGNC Official Full Name UBE2E1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40598 See related Ensembl:ENSG00000223791 AllianceGenome:HGNC:40598 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
UBE2E2, Official Symbol UBE2E2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 E2provided by HGNC Primary source HGNC:HGNC:12478 See related Ensembl:ENSG00000182247 MIM:602163; AllianceGenome:HGNC:12478 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBCH8 Summary Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 1.5), fat (RPKM 1.2) and 25 other tissues See more Orthologs mouse all
UBE2E3, Official Symbol UBE2E3provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 E3provided by HGNC Primary source HGNC:HGNC:12479 See related Ensembl:ENSG00000170035 MIM:604151; AllianceGenome:HGNC:12479 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBCH9; UbcM2 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in gall bladder (RPKM 6.0), thyroid (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
UBE2F, Official Symbol UBE2Fprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 F (putative)provided by HGNC Primary source HGNC:HGNC:12480 See related Ensembl:ENSG00000184182 MIM:617700; AllianceGenome:HGNC:12480 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCE2 Summary Enables NEDD8 conjugating enzyme activity. Involved in protein neddylation. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 11.8), thyroid (RPKM 10.6) and 25 other tissues See more Orthologs mouse all
UBE2F-SCLY, Official Symbol UBE2F-SCLYprovided by HGNC Official Full Name UBE2F-SCLY readthrough (NMD candidate)provided by HGNC Primary source HGNC:HGNC:48339 See related Ensembl:ENSG00000258984 AllianceGenome:HGNC:48339 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This locus represents naturally occurring read-through transcription between the neighboring UBE2F (ubiquitin-conjugating enzyme E2F) and SCLY (selenocysteine lyase) genes on chromosome 2. The read-through transcript is a candidate for non-sense mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in kidney (RPKM 6.6), testis (RPKM 5.6) and 25 other tissues See more
UBE2FP3, Official Symbol UBE2FP3provided by HGNC Official Full Name UBE2F pseudogene 3provided by HGNC Primary source HGNC:HGNC:44537 See related Ensembl:ENSG00000233337 AllianceGenome:HGNC:44537 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2G1, Official Symbol UBE2G1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 G1provided by HGNC Primary source HGNC:HGNC:12482 See related Ensembl:ENSG00000132388 MIM:601569; AllianceGenome:HGNC:12482 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC7; E217K; UBE2G Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 18.3), lymph node (RPKM 16.3) and 25 other tissues See more Orthologs mouse all
UBE2G2, Official Symbol UBE2G2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 G2provided by HGNC Primary source HGNC:HGNC:12483 See related Ensembl:ENSG00000184787 MIM:603124; AllianceGenome:HGNC:12483 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC7 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in spleen (RPKM 19.6), appendix (RPKM 19.0) and 25 other tissues See more Orthologs mouse all
UBE2H, Official Symbol UBE2Hprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Hprovided by HGNC Primary source HGNC:HGNC:12484 See related Ensembl:ENSG00000186591 MIM:601082; AllianceGenome:HGNC:12484 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GID3; UBC8; UBCH; UBCH2; E2-20K Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in heart (RPKM 38.0), adrenal (RPKM 36.4) and 25 other tissues See more Orthologs mouse all
UBE2I, Official Symbol UBE2Iprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Iprovided by HGNC Primary source HGNC:HGNC:12485 See related Ensembl:ENSG00000103275 MIM:601661; AllianceGenome:HGNC:12485 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P18; UBC9; C358B7.1 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues See more Orthologs mouse all
UBE2J1, Official Symbol UBE2J1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 J1provided by HGNC Primary source HGNC:HGNC:17598 See related Ensembl:ENSG00000198833 MIM:616175; AllianceGenome:HGNC:17598 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC6; UBC6E; Ubc6p; CGI-76; NCUBE1; HSPC153; HSPC205; NCUBE-1; HSU93243 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 49.6), bone marrow (RPKM 46.1) and 25 other tissues See more Orthologs mouse all
UBE2J2, Official Symbol UBE2J2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 J2provided by HGNC Primary source HGNC:HGNC:19268 See related Ensembl:ENSG00000160087 MIM:619756; AllianceGenome:HGNC:19268 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC6; NCUBE2; NCUBE-2; PRO2121 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 15.7), fat (RPKM 6.0) and 25 other tissues See more Orthologs mouse all
UBE2K, Official Symbol UBE2Kprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Kprovided by HGNC Primary source HGNC:HGNC:4914 See related Ensembl:ENSG00000078140 MIM:602846; AllianceGenome:HGNC:4914 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIG; HIP2; HYPG; UBC1; E2-25K Summary The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 24.1), thyroid (RPKM 17.9) and 25 other tissues See more Orthologs mouse all
UBE2L3, Official Symbol UBE2L3provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 L3provided by HGNC Primary source HGNC:HGNC:12488 See related Ensembl:ENSG00000185651 MIM:603721; AllianceGenome:HGNC:12488 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E2-F1; L-UBC; UBCH7; UbcM4 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in brain (RPKM 19.5), urinary bladder (RPKM 19.0) and 25 other tissues See more Orthologs mouse all
UBE2L5, Official Symbol UBE2L5provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 L5provided by HGNC Primary source HGNC:HGNC:13477 See related Ensembl:ENSG00000236444 AllianceGenome:HGNC:13477 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBCH7N2; UBE2L5P Summary Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein K11-linked ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
UBE2L6, Official Symbol UBE2L6provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 L6provided by HGNC Primary source HGNC:HGNC:12490 See related Ensembl:ENSG00000156587 MIM:603890; AllianceGenome:HGNC:12490 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RIG-B; UBCH8 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011] Expression Ubiquitous expression in spleen (RPKM 48.8), lymph node (RPKM 38.4) and 24 other tissues See more Orthologs mouse all
UBE2M, Official Symbol UBE2Mprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Mprovided by HGNC Primary source HGNC:HGNC:12491 See related Ensembl:ENSG00000130725 MIM:603173; AllianceGenome:HGNC:12491 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC12; hUbc12; UBC-RS2 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 24.7), testis (RPKM 23.2) and 25 other tissues See more Orthologs mouse all
UBE2MP1, Official Symbol UBE2MP1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 M pseudogene 1provided by HGNC Primary source HGNC:HGNC:32195 See related AllianceGenome:HGNC:32195 Gene type pseudo RefSeq status PROVISIONAL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2N, Official Symbol UBE2Nprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Nprovided by HGNC Primary source HGNC:HGNC:12492 See related Ensembl:ENSG00000177889 MIM:603679; AllianceGenome:HGNC:12492 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC13; UbcH13; UBCHBEN; HEL-S-71; UbcH-ben; UBCHBEN; UBC13 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
UBE2NL, Official Symbol UBE2NLprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 N like (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:31710 See related Ensembl:ENSG00000276380 AllianceGenome:HGNC:31710 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Li174 Summary This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence. [provided by RefSeq, Jun 2014] Annotation information Annotation category: suggests misassembly Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
UBE2O, Official Symbol UBE2Oprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Oprovided by HGNC Primary source HGNC:HGNC:29554 See related Ensembl:ENSG00000175931 MIM:617649; AllianceGenome:HGNC:29554 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E2-230K Summary Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 12.9), testis (RPKM 11.1) and 25 other tissues See more Orthologs mouse all
UBE2Q1, Official Symbol UBE2Q1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Q1provided by HGNC Primary source HGNC:HGNC:15698 See related Ensembl:ENSG00000160714 MIM:617429; AllianceGenome:HGNC:15698 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GTAP; NICE5; UBE2Q; NICE-5; PRO3094 Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 25.0), lymph node (RPKM 18.1) and 25 other tissues See more Orthologs mouse all
UBE2Q1-AS1, Official Symbol UBE2Q1-AS1provided by HGNC Official Full Name UBE2Q1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40722 See related Ensembl:ENSG00000229780 AllianceGenome:HGNC:40722 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 8.2), kidney (RPKM 4.9) and 25 other tissues See more
UBE2Q2, Official Symbol UBE2Q2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Q2provided by HGNC Primary source HGNC:HGNC:19248 See related Ensembl:ENSG00000140367 MIM:612501; AllianceGenome:HGNC:19248 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 12.2), prostate (RPKM 10.7) and 25 other tissues See more Orthologs mouse all
UBE2Q2P12, Official Symbol UBE2Q2P12provided by HGNC Official Full Name UBE2Q2 pseudogene 12provided by HGNC Primary source HGNC:HGNC:49523 See related Ensembl:ENSG00000197627 AllianceGenome:HGNC:49523 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2Q2P4Y, Official Symbol UBE2Q2P4Yprovided by HGNC Official Full Name UBE2Q2 pseudogene 4, Y-linkedprovided by HGNC Primary source HGNC:HGNC:38429 See related Ensembl:ENSG00000225491 AllianceGenome:HGNC:38429 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBE2Q2PY1
UBE2Q2P5Y, Official Symbol UBE2Q2P5Yprovided by HGNC Official Full Name UBE2Q2 pseudogene 5, Y-linkedprovided by HGNC Primary source HGNC:HGNC:38466 See related Ensembl:ENSG00000223636 AllianceGenome:HGNC:38466 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBE2Q2PY2
UBE2Q2P6, Official Symbol UBE2Q2P6provided by HGNC Official Full Name UBE2Q2 pseudogene 6provided by HGNC Primary source HGNC:HGNC:49412 See related Ensembl:ENSG00000275695 AllianceGenome:HGNC:49412 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2Q2P9, Official Symbol UBE2Q2P9provided by HGNC Official Full Name UBE2Q2 pseudogene 9provided by HGNC Primary source HGNC:HGNC:49517 See related Ensembl:ENSG00000244130 AllianceGenome:HGNC:49517 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2QL1, Official Symbol UBE2QL1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Q family like 1provided by HGNC Primary source HGNC:HGNC:37269 See related Ensembl:ENSG00000215218 MIM:615832; AllianceGenome:HGNC:37269 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 12.4), heart (RPKM 3.3) and 7 other tissues See more Orthologs mouse all
UBE2R2, Official Symbol UBE2R2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 R2provided by HGNC Primary source HGNC:HGNC:19907 See related Ensembl:ENSG00000107341 MIM:612506; AllianceGenome:HGNC:19907 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC3B; CDC34B; E2-CDC34B Summary Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 25.6), endometrium (RPKM 16.9) and 25 other tissues See more Orthologs mouse all
UBE2R2-AS1, Official Symbol UBE2R2-AS1provided by HGNC Official Full Name UBE2R2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49911 See related Ensembl:ENSG00000235481 AllianceGenome:HGNC:49911 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01251
UBE2S, Official Symbol UBE2Sprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Sprovided by HGNC Primary source HGNC:HGNC:17895 See related Ensembl:ENSG00000108106 MIM:610309; AllianceGenome:HGNC:17895 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EPF5; E2EPF; E2-EPF Summary This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues See more Orthologs mouse all
UBE2SP1, Official Symbol UBE2SP1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 S pseudogene 1provided by HGNC Primary source HGNC:HGNC:30864 See related AllianceGenome:HGNC:30864 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2SP2, Official Symbol UBE2SP2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 S pseudogene 2provided by HGNC Primary source HGNC:HGNC:32196 See related AllianceGenome:HGNC:32196 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2T, Official Symbol UBE2Tprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Tprovided by HGNC Primary source HGNC:HGNC:25009 See related Ensembl:ENSG00000077152 MIM:610538; AllianceGenome:HGNC:25009 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FANCT; PIG50; HSPC150 Summary The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] Expression Broad expression in testis (RPKM 10.4), bone marrow (RPKM 10.2) and 22 other tissues See more Orthologs mouse all
UBE2U, Official Symbol UBE2Uprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Uprovided by HGNC Primary source HGNC:HGNC:28559 See related Ensembl:ENSG00000177414 AllianceGenome:HGNC:28559 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be part of HULC complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 8.1) See more Orthologs mouse all
UBE2V1, Official Symbol UBE2V1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 V1provided by HGNC Primary source HGNC:HGNC:12494 See related Ensembl:ENSG00000244687 MIM:602995; AllianceGenome:HGNC:12494 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CIR1; UEV1; CROC1; UBE2V; UEV-1; UEV1A; CROC-1 Summary Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012] Expression Ubiquitous expression in brain (RPKM 23.0), placenta (RPKM 20.8) and 25 other tissues See more Orthologs mouse all
UBE2V1P10, Official Symbol UBE2V1P10provided by HGNC Official Full Name UBE2V1 pseudogene 10provided by HGNC Primary source HGNC:HGNC:44895 See related Ensembl:ENSG00000226590 AllianceGenome:HGNC:44895 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P12, Official Symbol UBE2V1P12provided by HGNC Official Full Name UBE2V1 pseudogene 12provided by HGNC Primary source HGNC:HGNC:44897 See related Ensembl:ENSG00000249191 AllianceGenome:HGNC:44897 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P13, Official Symbol UBE2V1P13provided by HGNC Official Full Name UBE2V1 pseudogene 13provided by HGNC Primary source HGNC:HGNC:52411 See related AllianceGenome:HGNC:52411 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P15, Official Symbol UBE2V1P15provided by HGNC Official Full Name UBE2V1 pseudogene 15provided by HGNC Primary source HGNC:HGNC:52414 See related AllianceGenome:HGNC:52414 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P4, Official Symbol UBE2V1P4provided by HGNC Official Full Name UBE2V1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:44886 See related Ensembl:ENSG00000233909 AllianceGenome:HGNC:44886 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P5, Official Symbol UBE2V1P5provided by HGNC Official Full Name UBE2V1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:44888 See related Ensembl:ENSG00000226582 AllianceGenome:HGNC:44888 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P6, Official Symbol UBE2V1P6provided by HGNC Official Full Name UBE2V1 pseudogene 6provided by HGNC Primary source HGNC:HGNC:44889 See related Ensembl:ENSG00000235995 AllianceGenome:HGNC:44889 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P7, Official Symbol UBE2V1P7provided by HGNC Official Full Name UBE2V1 pseudogene 7provided by HGNC Primary source HGNC:HGNC:44890 See related Ensembl:ENSG00000235061 AllianceGenome:HGNC:44890 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V1P9, Official Symbol UBE2V1P9provided by HGNC Official Full Name UBE2V1 pseudogene 9provided by HGNC Primary source HGNC:HGNC:44894 See related Ensembl:ENSG00000229667 AllianceGenome:HGNC:44894 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V2, Official Symbol UBE2V2provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 V2provided by HGNC Primary source HGNC:HGNC:12495 See related Ensembl:ENSG00000169139 MIM:603001; AllianceGenome:HGNC:12495 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1 Summary Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 22.2), adrenal (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
UBE2V2P1, Official Symbol UBE2V2P1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 V2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44885 See related Ensembl:ENSG00000226255 AllianceGenome:HGNC:44885 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2V2P4, Official Symbol UBE2V2P4provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 V2 pseudogene 4provided by HGNC Primary source HGNC:HGNC:44892 See related Ensembl:ENSG00000231849 AllianceGenome:HGNC:44892 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
UBE2W, Official Symbol UBE2Wprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Wprovided by HGNC Primary source HGNC:HGNC:25616 See related Ensembl:ENSG00000104343 MIM:614277; AllianceGenome:HGNC:25616 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC16; UBC-16 Summary This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] Expression Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.9) and 25 other tissues See more Orthologs mouse all
UBE2WP1, Official Symbol UBE2WP1provided by HGNC Official Full Name ubiquitin conjugating enzyme E2 W pseudogene 1provided by HGNC Primary source HGNC:HGNC:32198 See related Ensembl:ENSG00000234422 AllianceGenome:HGNC:32198 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBE2WP
UBE2Z, Official Symbol UBE2Zprovided by HGNC Official Full Name ubiquitin conjugating enzyme E2 Zprovided by HGNC Primary source HGNC:HGNC:25847 See related Ensembl:ENSG00000159202 MIM:611362; AllianceGenome:HGNC:25847 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as USE1; HOYS7 Summary This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in thyroid (RPKM 33.3), brain (RPKM 25.6) and 25 other tissues See more Orthologs mouse all
UBE3A, Official Symbol UBE3Aprovided by HGNC Official Full Name ubiquitin protein ligase E3Aprovided by HGNC Primary source HGNC:HGNC:12496 See related Ensembl:ENSG00000114062 MIM:601623; AllianceGenome:HGNC:12496 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AS; ANCR; PIX1; E6-AP; HPVE6A; EPVE6AP Summary This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 14.2), thyroid (RPKM 14.2) and 25 other tissues See more Orthologs mouse all