psui3905/ncbi_genes_summary huggingface dataset:
SP1, Official Symbol SP1provided by HGNC Official Full Name Sp1 transcription factorprovided by HGNC Primary source HGNC:HGNC:11205 See related Ensembl:ENSG00000185591 MIM:189906; AllianceGenome:HGNC:11205 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] Expression Ubiquitous expression in skin (RPKM 18.2), endometrium (RPKM 16.6) and 25 other tissues See more Orthologs mouse all
SP100, Official Symbol SP100provided by HGNC Official Full Name SP100 nuclear antigenprovided by HGNC Primary source HGNC:HGNC:11206 See related Ensembl:ENSG00000067066 MIM:604585; AllianceGenome:HGNC:11206 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as lysp100b Summary This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in lymph node (RPKM 13.9), bone marrow (RPKM 12.8) and 25 other tissues See more Orthologs mouse all
SP110, Official Symbol SP110provided by HGNC Official Full Name SP110 nuclear body proteinprovided by HGNC Primary source HGNC:HGNC:5401 See related Ensembl:ENSG00000135899 MIM:604457; AllianceGenome:HGNC:5401 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPR1; VODI; IFI41; IFI75 Summary The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 11.2), lymph node (RPKM 10.7) and 24 other tissues See more Orthologs all
SP140, Official Symbol SP140provided by HGNC Official Full Name SP140 nuclear body proteinprovided by HGNC Primary source HGNC:HGNC:17133 See related Ensembl:ENSG00000079263 MIM:608602; AllianceGenome:HGNC:17133 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYSP100; LYSP100-A; LYSP100-B Summary This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016] Expression Biased expression in lymph node (RPKM 12.2), spleen (RPKM 7.6) and 10 other tissues See more Orthologs all
SP140L, Official Symbol SP140Lprovided by HGNC Official Full Name SP140 nuclear body protein likeprovided by HGNC Primary source HGNC:HGNC:25105 See related Ensembl:ENSG00000185404 MIM:617747; AllianceGenome:HGNC:25105 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 8.7), spleen (RPKM 8.3) and 24 other tissues See more Orthologs all
SP2, Official Symbol SP2provided by HGNC Official Full Name Sp2 transcription factorprovided by HGNC Primary source HGNC:HGNC:11207 See related Ensembl:ENSG00000167182 MIM:601801; AllianceGenome:HGNC:11207 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues See more Orthologs mouse all
SP2-AS1, Official Symbol SP2-AS1provided by HGNC Official Full Name SP2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51341 See related Ensembl:ENSG00000234494 AllianceGenome:HGNC:51341 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
SP2-DT, Official Symbol SP2-DTprovided by HGNC Official Full Name SP2 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:55330 See related Ensembl:ENSG00000264920 AllianceGenome:HGNC:55330 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in heart (RPKM 11.0), testis (RPKM 9.2) and 24 other tissues See more
SP3, Official Symbol SP3provided by HGNC Official Full Name Sp3 transcription factorprovided by HGNC Primary source HGNC:HGNC:11208 See related Ensembl:ENSG00000172845 MIM:601804; AllianceGenome:HGNC:11208 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPR2 Summary This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010] Expression Ubiquitous expression in bone marrow (RPKM 21.0), thyroid (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
SP4, Official Symbol SP4provided by HGNC Official Full Name Sp4 transcription factorprovided by HGNC Primary source HGNC:HGNC:11209 See related Ensembl:ENSG00000105866 MIM:600540; AllianceGenome:HGNC:11209 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HF1B; SPR-1 Summary The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016] Expression Ubiquitous expression in ovary (RPKM 3.6), thyroid (RPKM 3.0) and 25 other tissues See more Orthologs mouse all
SP5, Official Symbol SP5provided by HGNC Official Full Name Sp5 transcription factorprovided by HGNC Primary source HGNC:HGNC:14529 See related Ensembl:ENSG00000204335 MIM:609391; AllianceGenome:HGNC:14529 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone morphogenesis; cellular response to organic cyclic compound; and post-anal tail morphogenesis. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in endometrium (RPKM 1.5), prostate (RPKM 0.9) and 16 other tissues See more Orthologs mouse all
SP6, Official Symbol SP6provided by HGNC Official Full Name Sp6 transcription factorprovided by HGNC Primary source HGNC:HGNC:14530 See related Ensembl:ENSG00000189120 MIM:608613; AllianceGenome:HGNC:14530 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AI1K; EPFN; KLF14; EPIPROFIN Summary SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008] Expression Biased expression in placenta (RPKM 11.3), skin (RPKM 2.8) and 6 other tissues See more Orthologs mouse all
SP7, Official Symbol SP7provided by HGNC Official Full Name Sp7 transcription factorprovided by HGNC Primary source HGNC:HGNC:17321 See related Ensembl:ENSG00000170374 MIM:606633; AllianceGenome:HGNC:17321 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OSX; OI11; OI12; osterix Summary This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010] Expression Low expression observed in reference dataset See more Orthologs mouse all
SP8, Official Symbol SP8provided by HGNC Official Full Name Sp8 transcription factorprovided by HGNC Primary source HGNC:HGNC:19196 See related Ensembl:ENSG00000164651 MIM:608306; AllianceGenome:HGNC:19196 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BTD Summary The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] Expression Biased expression in prostate (RPKM 3.9) and skin (RPKM 0.2) See more Orthologs mouse all
SP9, Official Symbol SP9provided by HGNC Official Full Name Sp9 transcription factorprovided by HGNC Primary source HGNC:HGNC:30690 See related Ensembl:ENSG00000217236 AllianceGenome:HGNC:30690 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF990 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
SPA17, Official Symbol SPA17provided by HGNC Official Full Name sperm autoantigenic protein 17provided by HGNC Primary source HGNC:HGNC:11210 See related Ensembl:ENSG00000064199 MIM:608621; AllianceGenome:HGNC:11210 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT22; SP17; SP17-1 Summary This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009] Expression Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues See more Orthologs mouse all
SPA17P1, Official Symbol SPA17P1provided by HGNC Official Full Name sperm autoantigenic protein 17 pseudogene 1provided by HGNC Primary source HGNC:HGNC:23224 See related AllianceGenome:HGNC:23224 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Sp17-2
SPAAR, Official Symbol SPAARprovided by HGNC Official Full Name small regulatory polypeptide of amino acid responseprovided by HGNC Primary source HGNC:HGNC:27244 See related Ensembl:ENSG00000235387 MIM:617627; AllianceGenome:HGNC:27244 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPAR; LINC00961 Summary Involved in cellular response to amino acid stimulus and negative regulation of TORC1 signaling. Located in late endosome membrane. Is integral component of lysosomal membrane. Colocalizes with lysosomal proton-transporting V-type ATPase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 6.4), testis (RPKM 5.2) and 8 other tissues See more Orthologs mouse all
SPACA1, Official Symbol SPACA1provided by HGNC Official Full Name sperm acrosome associated 1provided by HGNC Primary source HGNC:HGNC:14967 See related Ensembl:ENSG00000118434 MIM:612739; AllianceGenome:HGNC:14967 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAMP32; SPGF85 Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 11.4) See more Orthologs mouse all
SPACA3, Official Symbol SPACA3provided by HGNC Official Full Name sperm acrosome associated 3provided by HGNC Primary source HGNC:HGNC:16260 See related Ensembl:ENSG00000141316 MIM:612749; AllianceGenome:HGNC:16260 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT54; LYC3; LYZC; LYZL3; SLLP1; ALLP17 Summary The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression Restricted expression toward testis (RPKM 20.0) See more Orthologs mouse all
SPACA4, Official Symbol SPACA4provided by HGNC Official Full Name sperm acrosome associated 4provided by HGNC Primary source HGNC:HGNC:16441 See related Ensembl:ENSG00000177202 MIM:609932; AllianceGenome:HGNC:16441 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAMP14 Summary Predicted to be involved in cell adhesion. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
SPACA5, Official Symbol SPACA5provided by HGNC Official Full Name sperm acrosome associated 5provided by HGNC Primary source HGNC:HGNC:31353 See related Ensembl:ENSG00000171489 MIM:300593; AllianceGenome:HGNC:31353 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYC5; LYZL5; SLLP2; SLLP-X; UNQ6288; PNPK6288 Summary Predicted to enable lysozyme activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 3.7) See more Orthologs mouse all
SPACA5B, Official Symbol SPACA5Bprovided by HGNC Official Full Name sperm acrosome associated 5Bprovided by HGNC Primary source HGNC:HGNC:19142 See related Ensembl:ENSG00000171478 AllianceGenome:HGNC:19142 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LYZL5B Summary Predicted to enable lysozyme activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 8.6) See more Orthologs all
SPACA6, Official Symbol SPACA6provided by HGNC Official Full Name sperm acrosome associated 6provided by HGNC Primary source HGNC:HGNC:27113 See related Ensembl:ENSG00000182310 MIM:618945; AllianceGenome:HGNC:27113 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LET7EH; SPACA6P; LINC00085; NCRNA00085 Summary Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 2.0), placenta (RPKM 1.7) and 22 other tissues See more Orthologs mouse all
SPACA7, Official Symbol SPACA7provided by HGNC Official Full Name sperm acrosome associated 7provided by HGNC Primary source HGNC:HGNC:29575 See related Ensembl:ENSG00000153498 AllianceGenome:HGNC:29575 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C13orf28 Summary Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 19.1) See more Orthologs mouse all
SPACA9, Official Symbol SPACA9provided by HGNC Official Full Name sperm acrosome associated 9provided by HGNC Primary source HGNC:HGNC:1367 See related Ensembl:ENSG00000165698 MIM:618552; AllianceGenome:HGNC:1367 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Mast; C9orf9 Summary Predicted to enable calcium-dependent protein binding activity. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 17.0), thyroid (RPKM 3.5) and 15 other tissues See more Orthologs mouse all
SPAG1, Official Symbol SPAG1provided by HGNC Official Full Name sperm associated antigen 1provided by HGNC Primary source HGNC:HGNC:11212 See related Ensembl:ENSG00000104450 MIM:603395; AllianceGenome:HGNC:11212 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SP75; TPIS; CT140; CILD28; DNAAF13; HSD-3.8; HEL-S-268 Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 8.4), testis (RPKM 7.5) and 22 other tissues See more Orthologs mouse all
SPAG11A, Official Symbol SPAG11Aprovided by HGNC Official Full Name sperm associated antigen 11Aprovided by HGNC Primary source HGNC:HGNC:33342 See related Ensembl:ENSG00000178287 AllianceGenome:HGNC:33342 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HE2; EDDM2A Summary Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and cytolysis by host of symbiont cells. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
SPAG11B, Official Symbol SPAG11Bprovided by HGNC Official Full Name sperm associated antigen 11Bprovided by HGNC Primary source HGNC:HGNC:14534 See related Ensembl:ENSG00000164871 MIM:606560; AllianceGenome:HGNC:14534 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EP2; HE2; EP2C; EP2D; HE2C; EDDM2B; SPAG11; SPAG11A Summary This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
SPAG16, Official Symbol SPAG16provided by HGNC Official Full Name sperm associated antigen 16provided by HGNC Primary source HGNC:HGNC:23225 See related Ensembl:ENSG00000144451 MIM:612173; AllianceGenome:HGNC:23225 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PF20; WDR29 Summary Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008] Expression Broad expression in testis (RPKM 2.7), thyroid (RPKM 1.2) and 24 other tissues See more Orthologs mouse all
SPAG17, Official Symbol SPAG17provided by HGNC Official Full Name sperm associated antigen 17provided by HGNC Primary source HGNC:HGNC:26620 See related Ensembl:ENSG00000155761 MIM:616554; AllianceGenome:HGNC:26620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PF6; CT143; SPGF55 Summary This gene encodes a central pair protein present in the axonemes of cells with a "9 + 2" organization of microtubules. The encoded protein is required for the proper function of the axoneme. Mutations in the orthologous gene in mice lead to primary ciliary dyskinesia characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound respiratory distress, hydrocephalus, and neonatal lethality within twelve hours of birth due to impaired airway mucociliary clearance. Single-nucleotide polymorphisms in this gene are associated with human height and targeted mutations lead to skeletal malformations affecting the limbs in mice, suggesting a role for this gene in skeletal development. [provided by RefSeq, Feb 2017] Expression Biased expression in testis (RPKM 9.4), esophagus (RPKM 2.4) and 3 other tissues See more Orthologs mouse all
SPAG4, Official Symbol SPAG4provided by HGNC Official Full Name sperm associated antigen 4provided by HGNC Primary source HGNC:HGNC:11214 See related Ensembl:ENSG00000061656 MIM:603038; AllianceGenome:HGNC:11214 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SUN4; CT127 Summary The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] Expression Broad expression in testis (RPKM 8.6), pancreas (RPKM 6.3) and 20 other tissues See more Orthologs mouse all
SPAG5, Official Symbol SPAG5provided by HGNC Official Full Name sperm associated antigen 5provided by HGNC Primary source HGNC:HGNC:13452 See related Ensembl:ENSG00000076382 MIM:615562; AllianceGenome:HGNC:13452 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAP126; DEEPEST; hMAP126 Summary This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 49.5), bone marrow (RPKM 14.3) and 9 other tissues See more Orthologs mouse all
SPAG6, Official Symbol SPAG6provided by HGNC Official Full Name sperm associated antigen 6provided by HGNC Primary source HGNC:HGNC:11215 See related Ensembl:ENSG00000077327 MIM:605730; AllianceGenome:HGNC:11215 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as pf16; CT141; FAP194; CFAP194; Repro-SA-1 Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Restricted expression toward testis (RPKM 51.7) See more Orthologs mouse all
SPAG7, Official Symbol SPAG7provided by HGNC Official Full Name sperm associated antigen 7provided by HGNC Primary source HGNC:HGNC:11216 See related Ensembl:ENSG00000091640 MIM:610056; AllianceGenome:HGNC:11216 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACRP; FSA-1 Summary Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 25.7), kidney (RPKM 18.4) and 25 other tissues See more Orthologs mouse all
SPAG8, Official Symbol SPAG8provided by HGNC Official Full Name sperm associated antigen 8provided by HGNC Primary source HGNC:HGNC:14105 See related Ensembl:ENSG00000137098 MIM:605731; AllianceGenome:HGNC:14105 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMP1; BS-84; CT142; HSD-1; SPAG3; CILD28; hSMP-1 Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012] Expression Broad expression in testis (RPKM 10.6), lung (RPKM 2.8) and 16 other tissues See more Orthologs mouse all
SPAG9, Official Symbol SPAG9provided by HGNC Official Full Name sperm associated antigen 9provided by HGNC Primary source HGNC:HGNC:14524 See related Ensembl:ENSG00000008294 MIM:605430; AllianceGenome:HGNC:14524 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4 Summary This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] Expression Ubiquitous expression in brain (RPKM 29.0), testis (RPKM 27.0) and 25 other tissues See more Orthologs mouse all
SPAM1, Official Symbol SPAM1provided by HGNC Official Full Name sperm adhesion molecule 1provided by HGNC Primary source HGNC:HGNC:11217 See related Ensembl:ENSG00000106304 MIM:600930; AllianceGenome:HGNC:11217 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n Summary Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Restricted expression toward testis (RPKM 5.9) See more Orthologs all
SPANXA1, Official Symbol SPANXA1provided by HGNC Official Full Name sperm protein associated with the nucleus, X-linked, family member A1provided by HGNC Primary source HGNC:HGNC:11218 See related Ensembl:ENSG00000198021 MIM:300305; AllianceGenome:HGNC:11218 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAP-X; SPANX; CT11.1; CT11.3; SPAN-X; SPAN-Xa; SPAN-Xb; SPANX-A Summary Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 14.3) See more
SPANXA2, Official Symbol SPANXA2provided by HGNC Official Full Name SPANX family member A2provided by HGNC Primary source HGNC:HGNC:14328 See related Ensembl:ENSG00000203926 MIM:300493; AllianceGenome:HGNC:14328 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPANX; CT11.1; CT11.3; SPANXA; SPANXC; SPANX-A; SPANX-C Summary Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 14.3) See more
SPANXA2-OT1, Official Symbol SPANXA2-OT1provided by HGNC Official Full Name SPANXA2 overlapping transcript 1provided by HGNC Primary source HGNC:HGNC:31683 See related Ensembl:ENSG00000277215 AllianceGenome:HGNC:31683 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXorf18 Expression Low expression observed in reference dataset See more
SPANXB1, Official Symbol SPANXB1provided by HGNC Official Full Name SPANX family member B1provided by HGNC Primary source HGNC:HGNC:14329 See related Ensembl:ENSG00000227234 MIM:300669; AllianceGenome:HGNC:14329 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B1; CT11.2; SPANXB; SPANX-B; SPANXB2; SPANXF1; SPANXF2 Summary Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014] Expression Restricted expression toward testis (RPKM 16.7) See more
SPANXC, Official Symbol SPANXCprovided by HGNC Official Full Name SPANX family member Cprovided by HGNC Primary source HGNC:HGNC:14331 See related Ensembl:ENSG00000198573 MIM:300330; AllianceGenome:HGNC:14331 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CTp11; CT11.3; SPANXE; SPANX-C; SPANX-E Summary Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 12.8) See more
SPANXD, Official Symbol SPANXDprovided by HGNC Official Full Name SPANX family member Dprovided by HGNC Primary source HGNC:HGNC:14332 See related Ensembl:ENSG00000196406 MIM:300670; AllianceGenome:HGNC:14332 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT11.3; CT11.4; SPANXC; SPANXE; SPANX-C; SPANX-D; SPANX-E; dJ171K16.1 Summary Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014] Expression Restricted expression toward testis (RPKM 8.6) See more
SPANXN1, Official Symbol SPANXN1provided by HGNC Official Full Name SPANX family member N1provided by HGNC Primary source HGNC:HGNC:33174 See related Ensembl:ENSG00000203923 MIM:300664; AllianceGenome:HGNC:33174 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT11.6 Summary This gene represents one of several duplicated family members that are located on chromosome X. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. [provided by RefSeq, May 2010] Expression Low expression observed in reference dataset See more Orthologs all