psui3905/ncbi_genes_summary huggingface dataset:
FOXP4-AS1, Official Symbol FOXP4-AS1provided by HGNC Official Full Name FOXP4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50332 See related Ensembl:ENSG00000234753 AllianceGenome:HGNC:50332 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FOXQ1, Official Symbol FOXQ1provided by HGNC Official Full Name forkhead box Q1provided by HGNC Primary source HGNC:HGNC:20951 See related Ensembl:ENSG00000164379 MIM:612788; AllianceGenome:HGNC:20951 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HFH1 Summary FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[supplied by OMIM, May 2009] Orthologs mouse all
FOXR1, Official Symbol FOXR1provided by HGNC Official Full Name forkhead box R1provided by HGNC Primary source HGNC:HGNC:29980 See related Ensembl:ENSG00000176302 MIM:615755; AllianceGenome:HGNC:29980 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXN5; DLNB13 Summary This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008] Expression Restricted expression toward testis (RPKM 1.2) See more Orthologs mouse all
FOXR2, Official Symbol FOXR2provided by HGNC Official Full Name forkhead box R2provided by HGNC Primary source HGNC:HGNC:30469 See related Ensembl:ENSG00000189299 MIM:300949; AllianceGenome:HGNC:30469 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXN6 Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
FOXRED1, Official Symbol FOXRED1provided by HGNC Official Full Name FAD dependent oxidoreductase domain containing 1provided by HGNC Primary source HGNC:HGNC:26927 See related Ensembl:ENSG00000110074 MIM:613622; AllianceGenome:HGNC:26927 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H17; FP634; MC1DN19 Summary This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in brain (RPKM 6.2), liver (RPKM 5.5) and 25 other tissues See more Orthologs mouse all
FOXRED2, Official Symbol FOXRED2provided by HGNC Official Full Name FAD dependent oxidoreductase domain containing 2provided by HGNC Primary source HGNC:HGNC:26264 See related Ensembl:ENSG00000100350 MIM:613777; AllianceGenome:HGNC:26264 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ERFAD Summary Enables flavin adenine dinucleotide binding activity. Involved in ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 9.7), ovary (RPKM 6.3) and 24 other tissues See more Orthologs mouse all
FOXS1, Official Symbol FOXS1provided by HGNC Official Full Name forkhead box S1provided by HGNC Primary source HGNC:HGNC:3735 See related Ensembl:ENSG00000179772 MIM:602939; AllianceGenome:HGNC:3735 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKHL18; FREAC10 Summary The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008] Orthologs mouse all
FPGS, Official Symbol FPGSprovided by HGNC Official Full Name folylpolyglutamate synthaseprovided by HGNC Primary source HGNC:HGNC:3824 See related Ensembl:ENSG00000136877 MIM:136510; AllianceGenome:HGNC:3824 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in ovary (RPKM 14.6), fat (RPKM 12.1) and 25 other tissues See more Orthologs mouse all
FPGT, Official Symbol FPGTprovided by HGNC Official Full Name fucose-1-phosphate guanylyltransferaseprovided by HGNC Primary source HGNC:HGNC:3825 See related Ensembl:ENSG00000254685 MIM:603609; AllianceGenome:HGNC:3825 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GFPP Summary L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in thyroid (RPKM 7.2), kidney (RPKM 4.9) and 25 other tissues See more Orthologs mouse all
FPGT-TNNI3K, Official Symbol FPGT-TNNI3Kprovided by HGNC Official Full Name FPGT-TNNI3K readthroughprovided by HGNC Primary source HGNC:HGNC:42952 See related Ensembl:ENSG00000259030 AllianceGenome:HGNC:42952 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CARK; TNNI3K Summary Enables protein C-terminus binding activity; protein kinase activity; and troponin I binding activity. Involved in protein phosphorylation and regulation of heart contraction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in heart (RPKM 16.5), testis (RPKM 1.7) and 15 other tissues See more Orthologs all
FPR1, Official Symbol FPR1provided by HGNC Official Full Name formyl peptide receptor 1provided by HGNC Primary source HGNC:HGNC:3826 See related Ensembl:ENSG00000171051 MIM:136537; AllianceGenome:HGNC:3826 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPR; FMLP Summary This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010] Expression Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues See more Orthologs mouse all
FPR2, Official Symbol FPR2provided by HGNC Official Full Name formyl peptide receptor 2provided by HGNC Primary source HGNC:HGNC:3827 See related Ensembl:ENSG00000171049 MIM:136538; AllianceGenome:HGNC:3827 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALX; ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II Summary Enables amyloid-beta binding activity; scavenger receptor binding activity; and signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of monocyte chemotaxis; and regulation of defense response. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in appendix (RPKM 23.5), spleen (RPKM 4.6) and 5 other tissues See more Orthologs mouse all
FPR3, Official Symbol FPR3provided by HGNC Official Full Name formyl peptide receptor 3provided by HGNC Primary source HGNC:HGNC:3828 See related Ensembl:ENSG00000187474 MIM:136539; AllianceGenome:HGNC:3828 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FMLPY; FPRH1; FPRH2; FPRL2; RMLP-R-I; FMLP-R-II; FML2_HUMAN Summary Predicted to enable N-formyl peptide receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in appendix (RPKM 15.7), gall bladder (RPKM 12.8) and 22 other tissues See more Orthologs all
FRA10AC1, Official Symbol FRA10AC1provided by HGNC Official Full Name FRA10A associated CGG repeat 1provided by HGNC Primary source HGNC:HGNC:1162 See related Ensembl:ENSG00000148690 MIM:608866; AllianceGenome:HGNC:1162 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRA10A; NEDGFC; C10orf4; F26C11.1-like Summary The protein encoded by this gene is a nuclear phosphoprotein of unknown function. This gene contains a tandem CGG repeat region within a CpG island that normally consists of 8-14 repeats but can expand to over 200 repeats. The repeat region is within the 5' UTR of some transcript variants, but is intronic to another variant. The expanded repeat allele is a fragile site and becomes hypermethylated, causing a reduction in gene expression. A disease phenotype has not been associated with expanded alleles. This gene is found within the rare FRA10A folate-sensitive fragile site. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in brain (RPKM 6.1), testis (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
FRAS1, Official Symbol FRAS1provided by HGNC Official Full Name Fraser extracellular matrix complex subunit 1provided by HGNC Primary source HGNC:HGNC:19185 See related Ensembl:ENSG00000138759 MIM:607830; AllianceGenome:HGNC:19185 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRASRS1 Summary This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Expression Broad expression in thyroid (RPKM 6.8), kidney (RPKM 4.0) and 15 other tissues See more Orthologs mouse all
FRAT1, Official Symbol FRAT1provided by HGNC Official Full Name FRAT regulator of WNT signaling pathway 1provided by HGNC Primary source HGNC:HGNC:3944 See related Ensembl:ENSG00000165879 MIM:602503; AllianceGenome:HGNC:3944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008] Orthologs mouse all
FRAT2, Official Symbol FRAT2provided by HGNC Official Full Name FRAT regulator of WNT signaling pathway 2provided by HGNC Primary source HGNC:HGNC:16048 See related Ensembl:ENSG00000181274 MIM:605006; AllianceGenome:HGNC:16048 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRAT-2 Summary The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008] Orthologs mouse all
FREM1, Official Symbol FREM1provided by HGNC Official Full Name FRAS1 related extracellular matrix 1provided by HGNC Primary source HGNC:HGNC:23399 See related Ensembl:ENSG00000164946 MIM:608944; AllianceGenome:HGNC:23399 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BNAR; MOTA; TILRR; TRIGNO2; C9orf143; C9orf145; C9orf154 Summary This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011] Expression Broad expression in endometrium (RPKM 5.0), kidney (RPKM 2.2) and 14 other tissues See more Orthologs mouse all
FREM3, Official Symbol FREM3provided by HGNC Official Full Name FRAS1 related extracellular matrix 3provided by HGNC Primary source HGNC:HGNC:25172 See related Ensembl:ENSG00000183090 MIM:608946; AllianceGenome:HGNC:25172 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The protein belongs to the family of FRAS1/FREM extracellular matrix proteins and may play a role cell adhesion. [provided by RefSeq, Feb 2017] Expression Low expression observed in reference dataset See more Orthologs mouse all
FRG1, Official Symbol FRG1provided by HGNC Official Full Name FSHD region gene 1provided by HGNC Primary source HGNC:HGNC:3954 See related Ensembl:ENSG00000109536 MIM:601278; AllianceGenome:HGNC:3954 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FSG1; FRG1A Summary This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 24.3), fat (RPKM 19.1) and 25 other tissues See more Orthologs mouse all
FRG1-DT, Official Symbol FRG1-DTprovided by HGNC Official Full Name FRG1 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:51590 See related Ensembl:ENSG00000245685 AllianceGenome:HGNC:51590 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FRG2B, Official Symbol FRG2Bprovided by HGNC Official Full Name FSHD region gene 2 family member Bprovided by HGNC Primary source HGNC:HGNC:33518 See related Ensembl:ENSG00000225899 AllianceGenome:HGNC:33518 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more
FRG2C, Official Symbol FRG2Cprovided by HGNC Official Full Name FSHD region gene 2 family member Cprovided by HGNC Primary source HGNC:HGNC:33626 See related Ensembl:ENSG00000172969 AllianceGenome:HGNC:33626 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
FRG2GP, Official Symbol FRG2GPprovided by HGNC Official Full Name FSHD region gene 2 family member G, pseudogeneprovided by HGNC Primary source HGNC:HGNC:51364 See related Ensembl:ENSG00000260291 AllianceGenome:HGNC:51364 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FRG2IP, Official Symbol FRG2IPprovided by HGNC Official Full Name FSHD region gene 2 family member I, pseudogeneprovided by HGNC Primary source HGNC:HGNC:51795 See related Ensembl:ENSG00000260598 AllianceGenome:HGNC:51795 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FRG2LP, Official Symbol FRG2LPprovided by HGNC Official Full Name FSHD region gene 2 family member L, pseudogeneprovided by HGNC Primary source HGNC:HGNC:51798 See related Ensembl:ENSG00000267704 AllianceGenome:HGNC:51798 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FRG2MP, Official Symbol FRG2MPprovided by HGNC Official Full Name FSHD region gene 2 family member M, pseudogeneprovided by HGNC Primary source HGNC:HGNC:51799 See related Ensembl:ENSG00000275170 AllianceGenome:HGNC:51799 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FRK, Official Symbol FRKprovided by HGNC Official Full Name fyn related Src family tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:3955 See related Ensembl:ENSG00000111816 MIM:606573; AllianceGenome:HGNC:3955 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GTK; RAK; PTK5 Summary The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 3.0), duodenum (RPKM 2.8) and 23 other tissues See more Orthologs mouse all
FRMD1, Official Symbol FRMD1provided by HGNC Official Full Name FERM domain containing 1provided by HGNC Primary source HGNC:HGNC:21240 See related Ensembl:ENSG00000153303 AllianceGenome:HGNC:21240 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bA164L23.1 Summary Predicted to be involved in positive regulation of hippo signaling. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasmic side of apical plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 2.7), kidney (RPKM 2.0) and 7 other tissues See more Orthologs all
FRMD3, Official Symbol FRMD3provided by HGNC Official Full Name FERM domain containing 3provided by HGNC Primary source HGNC:HGNC:24125 See related Ensembl:ENSG00000172159 MIM:607619; AllianceGenome:HGNC:24125 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 4.1O; P410; EPB41LO; EPB41L4O Summary The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Broad expression in heart (RPKM 8.0), kidney (RPKM 5.0) and 20 other tissues See more Orthologs mouse all
FRMD4B, Official Symbol FRMD4Bprovided by HGNC Official Full Name FERM domain containing 4Bprovided by HGNC Primary source HGNC:HGNC:24886 See related Ensembl:ENSG00000114541 MIM:617467; AllianceGenome:HGNC:24886 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRSP1; 6030440G05Rik Summary This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in spleen (RPKM 7.8), esophagus (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
FRMD5, Official Symbol FRMD5provided by HGNC Official Full Name FERM domain containing 5provided by HGNC Primary source HGNC:HGNC:28214 See related Ensembl:ENSG00000171877 MIM:616309; AllianceGenome:HGNC:28214 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEDEMA Summary Enables integrin binding activity and protein kinase binding activity. Involved in negative regulation of cell motility; positive regulation of cell adhesion; and regulation of cell migration. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 6.9), heart (RPKM 4.6) and 4 other tissues See more Orthologs mouse all
FRMD6, Official Symbol FRMD6provided by HGNC Official Full Name FERM domain containing 6provided by HGNC Primary source HGNC:HGNC:19839 See related Ensembl:ENSG00000139926 MIM:614555; AllianceGenome:HGNC:19839 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EX1; Willin; C14orf31; c14_5320 Summary Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within apical constriction; cellular protein localization; and regulation of actin filament-based process. Predicted to be located in apical junction complex. Predicted to be active in cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in esophagus (RPKM 25.5), endometrium (RPKM 24.1) and 23 other tissues See more Orthologs mouse all
FRMD6-AS1, Official Symbol FRMD6-AS1provided by HGNC Official Full Name FRMD6 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:20129 See related Ensembl:ENSG00000258537 AllianceGenome:HGNC:20129 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C14orf82
FRMD6-AS2, Official Symbol FRMD6-AS2provided by HGNC Official Full Name FRMD6 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:43637 See related Ensembl:ENSG00000258537 AllianceGenome:HGNC:43637 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in endometrium (RPKM 4.6), prostate (RPKM 0.5) and 1 other tissue See more
FRMD7, Official Symbol FRMD7provided by HGNC Official Full Name FERM domain containing 7provided by HGNC Primary source HGNC:HGNC:8079 See related Ensembl:ENSG00000165694 MIM:300628; AllianceGenome:HGNC:8079 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NYS; NYS1; XIPAN Summary Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neuron projection development. Predicted to act upstream of or within several processes, including negative regulation of stress fiber assembly; positive regulation of lamellipodium assembly; and positive regulation of small GTPase mediated signal transduction. Located in cytosol; nucleoplasm; and plasma membrane. Implicated in congenital nystagmus 1. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
FRMD8, Official Symbol FRMD8provided by HGNC Official Full Name FERM domain containing 8provided by HGNC Primary source HGNC:HGNC:25462 See related Ensembl:ENSG00000126391 MIM:618337; AllianceGenome:HGNC:25462 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as iTAP; FKSG44 Summary Involved in positive regulation of tumor necrosis factor production. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 9.9), skin (RPKM 9.0) and 25 other tissues See more Orthologs mouse all
FRMD8P1, Official Symbol FRMD8P1provided by HGNC Official Full Name FERM domain containing 8 pseudogene 1provided by HGNC Primary source HGNC:HGNC:24690 See related Ensembl:ENSG00000227942 AllianceGenome:HGNC:24690 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in cytoskeleton. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
FRMPD1, Official Symbol FRMPD1provided by HGNC Official Full Name FERM and PDZ domain containing 1provided by HGNC Primary source HGNC:HGNC:29159 See related Ensembl:ENSG00000070601 MIM:616919; AllianceGenome:HGNC:29159 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRMD2 Summary Involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of protein-containing complex. Colocalizes with cell cortex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 3.6), skin (RPKM 1.1) and 2 other tissues See more Orthologs mouse all
FRMPD2, Official Symbol FRMPD2provided by HGNC Official Full Name FERM and PDZ domain containing 2provided by HGNC Primary source HGNC:HGNC:28572 See related Ensembl:ENSG00000170324 MIM:613323; AllianceGenome:HGNC:28572 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDZK4; PDZD5C; PDZK5C Summary This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009] Expression Biased expression in brain (RPKM 2.2), testis (RPKM 1.3) and 4 other tissues See more Orthologs mouse all
FRMPD2B, Official Symbol FRMPD2Bprovided by HGNC Official Full Name FERM and PDZ domain containing 2B (pseudogene)provided by HGNC Primary source HGNC:HGNC:16843 See related Ensembl:ENSG00000150175 AllianceGenome:HGNC:16843 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PDZK4; FRMPD2; PDZD5A; PDZD5B; PDZD5C; PDZK5A; PDZK5B; PDZK5C; FRMPDP2; FRMPD2L1; FRMPD2L2; FRMPD2P1; FRMPD2P2; yX59F3.2; bA556L1.2 Summary This gene represents a pseudogene of the FERM and PDZ domain containing 2 gene (FRMPD2, GeneID 143162). Along with the functional gene, this gene is located in a region of segmental duplication on chromosome 10q. [provided by RefSeq, Dec 2014] Expression Biased expression in brain (RPKM 7.0), testis (RPKM 3.5) and 2 other tissues See more
FRMPD3, Official Symbol FRMPD3provided by HGNC Official Full Name FERM and PDZ domain containing 3provided by HGNC Primary source HGNC:HGNC:29382 See related Ensembl:ENSG00000147234 MIM:301005; AllianceGenome:HGNC:29382 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that contains a PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain at the N-terminus followed by a FERM domain. The encoded protein is involved in signal transduction. The PDZ domain is thought to function in protein-protein interactions, mainly by binding to specific C-terminal peptides of other proteins. The FERM domain is found in proteins that are localized to the plasma membrane and are associated with the cytoskeleton. [provided by RefSeq, May 2017] Expression Biased expression in ovary (RPKM 3.1), brain (RPKM 2.3) and 8 other tissues See more Orthologs mouse all
FRMPD3-AS1, Official Symbol FRMPD3-AS1provided by HGNC Official Full Name FRMPD3 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41239 See related Ensembl:ENSG00000227610 AllianceGenome:HGNC:41239 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FRMPD4, Official Symbol FRMPD4provided by HGNC Official Full Name FERM and PDZ domain containing 4provided by HGNC Primary source HGNC:HGNC:29007 See related Ensembl:ENSG00000169933 MIM:300838; AllianceGenome:HGNC:29007 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRX104; PDZD10; PDZK10; XLID104 Summary This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010] Expression Biased expression in brain (RPKM 3.1) and heart (RPKM 0.2) See more Orthologs mouse all
FRRS1, Official Symbol FRRS1provided by HGNC Official Full Name ferric chelate reductase 1provided by HGNC Primary source HGNC:HGNC:27622 See related Ensembl:ENSG00000156869 MIM:611578; AllianceGenome:HGNC:27622 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDR2; SDFR2 Summary Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008] Expression Broad expression in liver (RPKM 6.9), placenta (RPKM 5.3) and 22 other tissues See more Orthologs mouse all
FRRS1L, Official Symbol FRRS1Lprovided by HGNC Official Full Name ferric chelate reductase 1 likeprovided by HGNC Primary source HGNC:HGNC:1362 See related Ensembl:ENSG00000260230 MIM:604574; AllianceGenome:HGNC:1362 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CG6; CG-6; DEE37; C9orf4; EIEE37 Summary This gene encodes a component of the outer-core of an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor protein in the brain. The encoded protein is thought to interact with inner-core components of the receptor, and play a role in the modulation of glutamate signaling. Mutations in this gene are associated with early infantile epileptic encephalopathy 37. [provided by RefSeq, Jul 2016] Expression Biased expression in brain (RPKM 11.1), ovary (RPKM 3.9) and 4 other tissues See more Orthologs mouse all
FRS2, Official Symbol FRS2provided by HGNC Official Full Name fibroblast growth factor receptor substrate 2provided by HGNC Primary source HGNC:HGNC:16971 See related Ensembl:ENSG00000166225 MIM:607743; AllianceGenome:HGNC:16971 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SNT; SNT1; FRS1A; FRS2A; SNT-1; FRS2alpha Summary Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 6.6), endometrium (RPKM 6.6) and 25 other tissues See more Orthologs mouse all
FRS3, Official Symbol FRS3provided by HGNC Official Full Name fibroblast growth factor receptor substrate 3provided by HGNC Primary source HGNC:HGNC:16970 See related Ensembl:ENSG00000137218 MIM:607744; AllianceGenome:HGNC:16970 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SNT2; FRS2B; SNT-2; FRS2beta; FRS2-beta Summary This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013] Expression Broad expression in testis (RPKM 6.0), brain (RPKM 2.3) and 23 other tissues See more Orthologs mouse all
FRY, Official Symbol FRYprovided by HGNC Official Full Name FRY microtubule binding proteinprovided by HGNC Primary source HGNC:HGNC:20367 See related Ensembl:ENSG00000073910 MIM:614818; AllianceGenome:HGNC:20367 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CG003; 13CDNA73; 214K23.2; C13orf14; bA207N4.2; bA37E23.1 Summary Predicted to enable enzyme inhibitor activity. Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be located in microtubule organizing center and spindle pole. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 6.3), brain (RPKM 4.5) and 25 other tissues See more Orthologs mouse all
FRY-AS1, Official Symbol FRY-AS1provided by HGNC Official Full Name FRY antisense RNA 1provided by HGNC Primary source HGNC:HGNC:39725 See related AllianceGenome:HGNC:39725 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FRYL, Official Symbol FRYLprovided by HGNC Official Full Name FRY like transcription coactivatorprovided by HGNC Primary source HGNC:HGNC:29127 See related Ensembl:ENSG00000075539 AllianceGenome:HGNC:29127 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MOR2; AF4p12; KIAA0826 Summary Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 15.9), lymph node (RPKM 5.8) and 24 other tissues See more Orthologs mouse all
FRZB, Official Symbol FRZBprovided by HGNC Official Full Name frizzled related proteinprovided by HGNC Primary source HGNC:HGNC:3959 See related Ensembl:ENSG00000162998 MIM:605083; AllianceGenome:HGNC:3959 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN Summary The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010] Expression Broad expression in spleen (RPKM 48.5), gall bladder (RPKM 25.9) and 20 other tissues See more Orthologs mouse all
FSBP, Official Symbol FSBPprovided by HGNC Official Full Name fibrinogen silencer binding proteinprovided by HGNC Primary source HGNC:HGNC:43653 See related Ensembl:ENSG00000265817 MIM:616306; AllianceGenome:HGNC:43653 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 1.6), prostate (RPKM 1.4) and 25 other tissues See more Orthologs mouse all
FSCB, Official Symbol FSCBprovided by HGNC Official Full Name fibrous sheath CABYR binding proteinprovided by HGNC Primary source HGNC:HGNC:20494 See related Ensembl:ENSG00000189139 MIM:611779; AllianceGenome:HGNC:20494 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C14orf155 Summary Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Predicted to be active in sperm fibrous sheath and sperm principal piece. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
FSCN1, Official Symbol FSCN1provided by HGNC Official Full Name fascin actin-bundling protein 1provided by HGNC Primary source HGNC:HGNC:11148 See related Ensembl:ENSG00000075618 MIM:602689; AllianceGenome:HGNC:11148 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSN; SNL; p55; FAN1 Summary This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011] Expression Broad expression in brain (RPKM 42.7), placenta (RPKM 36.2) and 24 other tissues See more Orthologs mouse all
FSCN2, Official Symbol FSCN2provided by HGNC Official Full Name fascin actin-bundling protein 2, retinalprovided by HGNC Primary source HGNC:HGNC:3960 See related Ensembl:ENSG00000186765 MIM:607643; AllianceGenome:HGNC:3960 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RFSN; RP30 Summary This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all