psui3905/ncbi_genes_summary huggingface dataset:
TMEM78, Official Symbol TMEM78provided by HGNC Official Full Name transmembrane protein 78provided by HGNC Primary source HGNC:HGNC:32307 See related Ensembl:ENSG00000177800 AllianceGenome:HGNC:32307 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
TMEM79, Official Symbol TMEM79provided by HGNC Official Full Name transmembrane protein 79provided by HGNC Primary source HGNC:HGNC:28196 See related Ensembl:ENSG00000163472 MIM:615531; AllianceGenome:HGNC:28196 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MATT Summary Enables identical protein binding activity. Predicted to be involved in several processes, including epithelial cell maturation; establishment of skin barrier; and positive regulation of epidermis development. Predicted to act upstream of or within cornification; cuticle development; and hair follicle morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in lysosomal membrane and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 34.9), esophagus (RPKM 32.0) and 6 other tissues See more Orthologs mouse all
TMEM80, Official Symbol TMEM80provided by HGNC Official Full Name transmembrane protein 80provided by HGNC Primary source HGNC:HGNC:27453 See related Ensembl:ENSG00000177042 MIM:620248; AllianceGenome:HGNC:27453 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in non-motile cilium assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in ciliary transition zone. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.9), prostate (RPKM 7.1) and 25 other tissues See more Orthologs mouse all
TMEM81, Official Symbol TMEM81provided by HGNC Official Full Name transmembrane protein 81provided by HGNC Primary source HGNC:HGNC:32349 See related Ensembl:ENSG00000174529 AllianceGenome:HGNC:32349 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC3107; UNQ2788; KVLA2788 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
TMEM82, Official Symbol TMEM82provided by HGNC Official Full Name transmembrane protein 82provided by HGNC Primary source HGNC:HGNC:32350 See related Ensembl:ENSG00000162460 AllianceGenome:HGNC:32350 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in duodenum (RPKM 10.3), small intestine (RPKM 8.5) and 3 other tissues See more Orthologs mouse all
TMEM86A, Official Symbol TMEM86Aprovided by HGNC Official Full Name transmembrane protein 86Aprovided by HGNC Primary source HGNC:HGNC:26890 See related Ensembl:ENSG00000151117 AllianceGenome:HGNC:26890 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable alkenylglycerophosphocholine hydrolase activity and alkenylglycerophosphoethanolamine hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 12.8), skin (RPKM 8.6) and 23 other tissues See more Orthologs mouse all
TMEM86B, Official Symbol TMEM86Bprovided by HGNC Official Full Name transmembrane protein 86Bprovided by HGNC Primary source HGNC:HGNC:28448 See related Ensembl:ENSG00000180089 MIM:617806; AllianceGenome:HGNC:28448 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables alkenylglycerophosphocholine hydrolase activity; alkenylglycerophosphoethanolamine hydrolase activity; and identical protein binding activity. Involved in ether lipid metabolic process. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 7.8), duodenum (RPKM 5.4) and 24 other tissues See more Orthologs mouse all
TMEM87A, Official Symbol TMEM87Aprovided by HGNC Official Full Name transmembrane protein 87Aprovided by HGNC Primary source HGNC:HGNC:24522 See related Ensembl:ENSG00000103978 AllianceGenome:HGNC:24522 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ELKIN1 Summary Involved in retrograde transport, endosome to Golgi. Located in Golgi cisterna membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 20.9), prostate (RPKM 20.6) and 25 other tissues See more Orthologs mouse all
TMEM87B, Official Symbol TMEM87Bprovided by HGNC Official Full Name transmembrane protein 87Bprovided by HGNC Primary source HGNC:HGNC:25913 See related Ensembl:ENSG00000153214 MIM:617203; AllianceGenome:HGNC:25913 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016] Expression Ubiquitous expression in prostate (RPKM 18.0), colon (RPKM 17.7) and 25 other tissues See more Orthologs mouse all
TMEM88, Official Symbol TMEM88provided by HGNC Official Full Name transmembrane protein 88provided by HGNC Primary source HGNC:HGNC:32371 See related Ensembl:ENSG00000167874 MIM:617813; AllianceGenome:HGNC:32371 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable PDZ domain binding activity. Involved in negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; and protein stabilization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in fat (RPKM 7.7), placenta (RPKM 7.1) and 23 other tissues See more Orthologs mouse all
TMEM88B, Official Symbol TMEM88Bprovided by HGNC Official Full Name transmembrane protein 88Bprovided by HGNC Primary source HGNC:HGNC:37099 See related Ensembl:ENSG00000205116 AllianceGenome:HGNC:37099 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable PDZ domain binding activity. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 2.6), testis (RPKM 0.2) and 1 other tissue See more Orthologs mouse all
TMEM89, Official Symbol TMEM89provided by HGNC Official Full Name transmembrane protein 89provided by HGNC Primary source HGNC:HGNC:32372 See related Ensembl:ENSG00000183396 AllianceGenome:HGNC:32372 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 5.1) See more Orthologs mouse all
TMEM8B, Official Symbol TMEM8Bprovided by HGNC Official Full Name transmembrane protein 8Bprovided by HGNC Primary source HGNC:HGNC:21427 See related Ensembl:ENSG00000137103 MIM:616888; AllianceGenome:HGNC:21427 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NAG5; NGX6; FP588; NAG-5; NGX6a; C9orf127; LINC00950 Summary Involved in cell-matrix adhesion. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 4.5), ovary (RPKM 3.3) and 23 other tissues See more Orthologs mouse all
TMEM9, Official Symbol TMEM9provided by HGNC Official Full Name transmembrane protein 9provided by HGNC Primary source HGNC:HGNC:18823 See related Ensembl:ENSG00000116857 MIM:616877; AllianceGenome:HGNC:18823 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DERM4; TMEM9A Summary Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 25.4), thyroid (RPKM 25.3) and 25 other tissues See more Orthologs mouse all
TMEM91, Official Symbol TMEM91provided by HGNC Official Full Name transmembrane protein 91provided by HGNC Primary source HGNC:HGNC:32393 See related Ensembl:ENSG00000142046 MIM:618294; AllianceGenome:HGNC:32393 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DSPC3; IFITMD6; SynDIG3 Summary Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 6.3), testis (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
TMEM92, Official Symbol TMEM92provided by HGNC Official Full Name transmembrane protein 92provided by HGNC Primary source HGNC:HGNC:26579 See related Ensembl:ENSG00000167105 MIM:619604; AllianceGenome:HGNC:26579 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 10.1), duodenum (RPKM 7.9) and 7 other tissues See more Orthologs all
TMEM92-AS1, Official Symbol TMEM92-AS1provided by HGNC Official Full Name TMEM92 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50442 See related Ensembl:ENSG00000251179 AllianceGenome:HGNC:50442 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as lncRNA-508851; TCONS_00025237 Expression Biased expression in small intestine (RPKM 1.1), duodenum (RPKM 0.5) and 8 other tissues See more
TMEM94, Official Symbol TMEM94provided by HGNC Official Full Name transmembrane protein 94provided by HGNC Primary source HGNC:HGNC:28983 See related Ensembl:ENSG00000177728 MIM:618163; AllianceGenome:HGNC:28983 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IDDCDF; KIAA0195 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 13.2), testis (RPKM 12.0) and 25 other tissues See more Orthologs mouse all
TMEM95, Official Symbol TMEM95provided by HGNC Official Full Name transmembrane protein 95provided by HGNC Primary source HGNC:HGNC:27898 See related Ensembl:ENSG00000182896 MIM:617814; AllianceGenome:HGNC:27898 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UNQ9390 Summary Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in sperm plasma membrane. Predicted to be integral component of membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 4.1), thyroid (RPKM 3.1) and 1 other tissue See more Orthologs mouse all
TMEM97, Official Symbol TMEM97provided by HGNC Official Full Name transmembrane protein 97provided by HGNC Primary source HGNC:HGNC:28106 See related Ensembl:ENSG00000109084 MIM:612912; AllianceGenome:HGNC:28106 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAC30; sigma2R Summary TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009] Expression Broad expression in testis (RPKM 51.1), liver (RPKM 43.9) and 23 other tissues See more Orthologs mouse all
TMEM97P1, Official Symbol TMEM97P1provided by HGNC Official Full Name transmembrane protein 97 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39640 See related Ensembl:ENSG00000234030 AllianceGenome:HGNC:39640 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TMEM98, Official Symbol TMEM98provided by HGNC Official Full Name transmembrane protein 98provided by HGNC Primary source HGNC:HGNC:24529 See related Ensembl:ENSG00000006042 MIM:615949; AllianceGenome:HGNC:24529 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TADA1 Summary This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014] Expression Ubiquitous expression in ovary (RPKM 69.4), endometrium (RPKM 44.6) and 23 other tissues See more Orthologs mouse all
TMEM9B, Official Symbol TMEM9Bprovided by HGNC Official Full Name TMEM9 domain family member Bprovided by HGNC Primary source HGNC:HGNC:1168 See related Ensembl:ENSG00000175348 MIM:620293; AllianceGenome:HGNC:1168 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C11orf15 Summary Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in early endosome membrane and lysosomal membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 35.7), colon (RPKM 33.6) and 25 other tissues See more Orthologs mouse all
TMEM9B-AS1, Official Symbol TMEM9B-AS1provided by HGNC Official Full Name TMEM9B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:19230 See related Ensembl:ENSG00000254860 AllianceGenome:HGNC:19230 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C11orf18 Expression Ubiquitous expression in colon (RPKM 5.5), kidney (RPKM 4.4) and 24 other tissues See more
TMF1, Official Symbol TMF1provided by HGNC Official Full Name TATA element modulatory factor 1provided by HGNC Primary source HGNC:HGNC:11870 See related Ensembl:ENSG00000144747 MIM:601126; AllianceGenome:HGNC:11870 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMF; ARA160 Summary Enables androgen receptor binding activity and nuclear receptor coactivator activity. Involved in androgen receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 20.2), thyroid (RPKM 13.7) and 25 other tissues See more Orthologs mouse all
TMIE, Official Symbol TMIEprovided by HGNC Official Full Name transmembrane inner earprovided by HGNC Primary source HGNC:HGNC:30800 See related Ensembl:ENSG00000181585 MIM:607237; AllianceGenome:HGNC:30800 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB6 Summary This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009] Expression Broad expression in adrenal (RPKM 2.0), brain (RPKM 1.3) and 20 other tissues See more Orthologs mouse all
TMIGD1, Official Symbol TMIGD1provided by HGNC Official Full Name transmembrane and immunoglobulin domain containing 1provided by HGNC Primary source HGNC:HGNC:32431 See related Ensembl:ENSG00000182271 AllianceGenome:HGNC:32431 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMIGD; UNQ9372 Summary Involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of membrane permeability. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 67.8) and colon (RPKM 47.6) See more Orthologs mouse all
TMIGD2, Official Symbol TMIGD2provided by HGNC Official Full Name transmembrane and immunoglobulin domain containing 2provided by HGNC Primary source HGNC:HGNC:28324 See related Ensembl:ENSG00000167664 MIM:614715; AllianceGenome:HGNC:28324 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD28H; IGPR1; IGPR-1 Summary Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lymph node (RPKM 1.8), spleen (RPKM 1.5) and 14 other tissues See more Orthologs all
TMIGD3, Official Symbol TMIGD3provided by HGNC Official Full Name transmembrane and immunoglobulin domain containing 3provided by HGNC Primary source HGNC:HGNC:51375 See related Ensembl:ENSG00000121933 AllianceGenome:HGNC:51375 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AD026 Summary This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014] Expression Biased expression in testis (RPKM 14.5), adrenal (RPKM 4.5) and 10 other tissues See more Orthologs mouse all
TMLHE, Official Symbol TMLHEprovided by HGNC Official Full Name trimethyllysine hydroxylase, epsilonprovided by HGNC Primary source HGNC:HGNC:18308 See related Ensembl:ENSG00000185973 MIM:300777; AllianceGenome:HGNC:18308 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMLD; TMLH; BBOX2; AUTSX6; TMLHED; XAP130 Summary This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Expression Ubiquitous expression in heart (RPKM 6.4), fat (RPKM 5.3) and 25 other tissues See more Orthologs mouse all
TMLHE-AS1, Official Symbol TMLHE-AS1provided by HGNC Official Full Name TMLHE antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44261 See related Ensembl:ENSG00000224533 AllianceGenome:HGNC:44261 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
TMOD1, Official Symbol TMOD1provided by HGNC Official Full Name tropomodulin 1provided by HGNC Primary source HGNC:HGNC:11871 See related Ensembl:ENSG00000136842 MIM:190930; AllianceGenome:HGNC:11871 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMOD; ETMOD; D9S57E Summary This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] Expression Broad expression in heart (RPKM 48.5), adrenal (RPKM 34.3) and 23 other tissues See more Orthologs mouse all
TMOD2, Official Symbol TMOD2provided by HGNC Official Full Name tropomodulin 2provided by HGNC Primary source HGNC:HGNC:11872 See related Ensembl:ENSG00000128872 MIM:602928; AllianceGenome:HGNC:11872 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NTMOD; N-TMOD Summary This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008] Expression Biased expression in brain (RPKM 47.3), appendix (RPKM 3.6) and 7 other tissues See more Orthologs mouse all
TMOD3, Official Symbol TMOD3provided by HGNC Official Full Name tropomodulin 3provided by HGNC Primary source HGNC:HGNC:11873 See related Ensembl:ENSG00000138594 MIM:605112; AllianceGenome:HGNC:11873 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UTMOD Summary Enables cadherin binding activity involved in cell-cell adhesion. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 45.0), lung (RPKM 23.8) and 24 other tissues See more Orthologs mouse all
TMOD4, Official Symbol TMOD4provided by HGNC Official Full Name tropomodulin 4provided by HGNC Primary source HGNC:HGNC:11874 See related Ensembl:ENSG00000163157 MIM:605834; AllianceGenome:HGNC:11874 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SK-TMOD Summary Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Located in striated muscle thin filament. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in prostate (RPKM 6.3), esophagus (RPKM 3.1) and 4 other tissues See more Orthologs mouse all
TMPO, Official Symbol TMPOprovided by HGNC Official Full Name thymopoietinprovided by HGNC Primary source HGNC:HGNC:11875 See related Ensembl:ENSG00000120802 MIM:188380; AllianceGenome:HGNC:11875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TP; LAP2; CMD1T; LEMD4; PRO0868 Summary Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019] Expression Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 19.4) and 25 other tissues See more Orthologs mouse all
TMPO-AS1, Official Symbol TMPO-AS1provided by HGNC Official Full Name TMPO antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44158 See related Ensembl:ENSG00000257167 AllianceGenome:HGNC:44158 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 6.1), colon (RPKM 3.0) and 20 other tissues See more
TMPOP2, Official Symbol TMPOP2provided by HGNC Official Full Name thymopoietin pseudogene 2provided by HGNC Primary source HGNC:HGNC:50860 See related Ensembl:ENSG00000262904 AllianceGenome:HGNC:50860 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as lncRNA-EBIC
TMPPE, Official Symbol TMPPEprovided by HGNC Official Full Name transmembrane protein with metallophosphoesterase domainprovided by HGNC Primary source HGNC:HGNC:33865 See related Ensembl:ENSG00000188167 AllianceGenome:HGNC:33865 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable hydrolase activity and metal ion binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 2.1), appendix (RPKM 1.0) and 25 other tissues See more Orthologs mouse all
TMPRSS11A, Official Symbol TMPRSS11Aprovided by HGNC Official Full Name transmembrane serine protease 11Aprovided by HGNC Primary source HGNC:HGNC:27954 See related Ensembl:ENSG00000187054 MIM:611704; AllianceGenome:HGNC:27954 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HESP; ECRG1; HATL1 Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward esophagus (RPKM 55.7) See more Orthologs all
TMPRSS11B, Official Symbol TMPRSS11Bprovided by HGNC Official Full Name transmembrane serine protease 11Bprovided by HGNC Primary source HGNC:HGNC:25398 See related Ensembl:ENSG00000185873 AllianceGenome:HGNC:25398 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HATL5 Summary Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward esophagus (RPKM 184.2) See more Orthologs all
TMPRSS11BNL, Official Symbol TMPRSS11BNLprovided by HGNC Official Full Name TMPRSS11B N-terminal like (pseudogene)provided by HGNC Primary source HGNC:HGNC:37262 See related Ensembl:ENSG00000250026 AllianceGenome:HGNC:37262 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward esophagus (RPKM 6.7) See more
TMPRSS11CP, Official Symbol TMPRSS11CPprovided by HGNC Official Full Name transmembrane serine protease 11C, pseudogeneprovided by HGNC Primary source HGNC:HGNC:31934 See related Ensembl:ENSG00000232398 AllianceGenome:HGNC:31934 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in self proteolysis. Predicted to be located in dendrite and perikaryon. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
TMPRSS11D, Official Symbol TMPRSS11Dprovided by HGNC Official Full Name transmembrane serine protease 11Dprovided by HGNC Primary source HGNC:HGNC:24059 See related Ensembl:ENSG00000153802 MIM:605369; AllianceGenome:HGNC:24059 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ASP; HAT Summary This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Restricted expression toward esophagus (RPKM 30.2) See more Orthologs mouse all
TMPRSS11E, Official Symbol TMPRSS11Eprovided by HGNC Official Full Name transmembrane serine protease 11Eprovided by HGNC Primary source HGNC:HGNC:24465 See related Ensembl:ENSG00000087128 MIM:610399; AllianceGenome:HGNC:24465 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DESC1; TMPRSS11E2 Summary Predicted to enable serine-type peptidase activity. Involved in cognition. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward esophagus (RPKM 128.8) See more Orthologs all
TMPRSS11F, Official Symbol TMPRSS11Fprovided by HGNC Official Full Name transmembrane serine protease 11Fprovided by HGNC Primary source HGNC:HGNC:29994 See related Ensembl:ENSG00000198092 AllianceGenome:HGNC:29994 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HATL4 Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of water loss via skin. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in esophagus (RPKM 7.7) and skin (RPKM 4.0) See more Orthologs all
TMPRSS12, Official Symbol TMPRSS12provided by HGNC Official Full Name transmembrane serine protease 12provided by HGNC Primary source HGNC:HGNC:28779 See related Ensembl:ENSG00000186452 AllianceGenome:HGNC:28779 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT151 Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within binding activity of sperm to zona pellucida and protein processing. Predicted to be located in acrosomal vesicle. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 13.9) See more Orthologs mouse all
TMPRSS13, Official Symbol TMPRSS13provided by HGNC Official Full Name transmembrane serine protease 13provided by HGNC Primary source HGNC:HGNC:29808 See related Ensembl:ENSG00000137747 MIM:610050; AllianceGenome:HGNC:29808 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSP; MSPL; MSPS; TMPRSS11 Summary This gene encodes a member of the type II transmembrane serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Biased expression in skin (RPKM 9.7), esophagus (RPKM 3.1) and 4 other tissues See more Orthologs mouse all
TMPRSS15, Official Symbol TMPRSS15provided by HGNC Official Full Name transmembrane serine protease 15provided by HGNC Primary source HGNC:HGNC:9490 See related Ensembl:ENSG00000154646 MIM:606635; AllianceGenome:HGNC:9490 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ENTK; PRSS7 Summary This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008] Expression Restricted expression toward duodenum (RPKM 404.7) See more Orthologs mouse all
TMPRSS2, Official Symbol TMPRSS2provided by HGNC Official Full Name transmembrane serine protease 2provided by HGNC Primary source HGNC:HGNC:11876 See related Ensembl:ENSG00000184012 MIM:602060; AllianceGenome:HGNC:11876 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRSS10 Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Biased expression in prostate (RPKM 167.2), colon (RPKM 59.9) and 10 other tissues See more Orthologs mouse all
TMPRSS3, Official Symbol TMPRSS3provided by HGNC Official Full Name transmembrane serine protease 3provided by HGNC Primary source HGNC:HGNC:11877 See related Ensembl:ENSG00000160183 MIM:605511; AllianceGenome:HGNC:11877 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB8; DFNB10; ECHOS1; TADG12 Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] Expression Biased expression in stomach (RPKM 9.6), gall bladder (RPKM 3.7) and 7 other tissues See more Orthologs mouse all
TMPRSS4, Official Symbol TMPRSS4provided by HGNC Official Full Name transmembrane serine protease 4provided by HGNC Primary source HGNC:HGNC:11878 See related Ensembl:ENSG00000137648 MIM:606565; AllianceGenome:HGNC:11878 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAP2; CAPH2; MT-SP2; TMPRSS3 Summary This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Biased expression in colon (RPKM 31.0), urinary bladder (RPKM 28.2) and 8 other tissues See more Orthologs mouse all
TMPRSS5, Official Symbol TMPRSS5provided by HGNC Official Full Name transmembrane serine protease 5provided by HGNC Primary source HGNC:HGNC:14908 See related Ensembl:ENSG00000166682 MIM:606751; AllianceGenome:HGNC:14908 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPINESIN Summary This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Biased expression in brain (RPKM 1.2), salivary gland (RPKM 0.5) and 9 other tissues See more Orthologs mouse all
TMPRSS6, Official Symbol TMPRSS6provided by HGNC Official Full Name transmembrane serine protease 6provided by HGNC Primary source HGNC:HGNC:16517 See related Ensembl:ENSG00000187045 MIM:609862; AllianceGenome:HGNC:16517 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MT2; IRIDA Summary The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Biased expression in liver (RPKM 19.4), stomach (RPKM 1.7) and 1 other tissue See more Orthologs mouse all
TMPRSS7, Official Symbol TMPRSS7provided by HGNC Official Full Name transmembrane serine protease 7provided by HGNC Primary source HGNC:HGNC:30846 See related Ensembl:ENSG00000176040 AllianceGenome:HGNC:30846 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
TMPRSS9, Official Symbol TMPRSS9provided by HGNC Official Full Name transmembrane serine protease 9provided by HGNC Primary source HGNC:HGNC:30079 See related Ensembl:ENSG00000178297 MIM:610477; AllianceGenome:HGNC:30079 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016] Expression Broad expression in spleen (RPKM 1.4), testis (RPKM 1.2) and 25 other tissues See more Orthologs mouse all