psui3905/ncbi_genes_summary huggingface dataset:
TPM1, Official Symbol TPM1provided by HGNC Official Full Name tropomyosin 1provided by HGNC Primary source HGNC:HGNC:12010 See related Ensembl:ENSG00000140416 MIM:191010; AllianceGenome:HGNC:12010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha Summary This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022] Expression Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues See more Orthologs mouse all
TPM1-AS, Official Symbol TPM1-ASprovided by HGNC Official Full Name TPM1 antisense RNAprovided by HGNC Primary source HGNC:HGNC:53635 See related AllianceGenome:HGNC:53635 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPM1-AS1
TPM2, Official Symbol TPM2provided by HGNC Official Full Name tropomyosin 2provided by HGNC Primary source HGNC:HGNC:12011 See related Ensembl:ENSG00000198467 MIM:190990; AllianceGenome:HGNC:12011 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DA1; DA2B; NEM4; TMSB; AMCD1; DA2B4; CMYP23; HEL-S-273 Summary This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] Expression Broad expression in prostate (RPKM 355.8), endometrium (RPKM 279.3) and 16 other tissues See more Orthologs mouse all
TPM3, Official Symbol TPM3provided by HGNC Official Full Name tropomyosin 3provided by HGNC Primary source HGNC:HGNC:12012 See related Ensembl:ENSG00000143549 MIM:191030; AllianceGenome:HGNC:12012 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; CMYP4A; CMYP4B; TM30nm; TPM3nu; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5 Summary This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] Expression Ubiquitous expression in bone marrow (RPKM 43.6), appendix (RPKM 31.3) and 25 other tissues See more Orthologs mouse all
TPM3P2, Official Symbol TPM3P2provided by HGNC Official Full Name tropomyosin 3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:16556 See related AllianceGenome:HGNC:16556 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPM5P; dJ1125A11.2
TPM3P4, Official Symbol TPM3P4provided by HGNC Official Full Name tropomyosin 3 pseudogene 4provided by HGNC Primary source HGNC:HGNC:39167 See related AllianceGenome:HGNC:39167 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPM3P9, Official Symbol TPM3P9provided by HGNC Official Full Name tropomyosin 3 pseudogene 9provided by HGNC Primary source HGNC:HGNC:44142 See related Ensembl:ENSG00000241015 AllianceGenome:HGNC:44142 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in prostate (RPKM 10.6), placenta (RPKM 2.7) and 23 other tissues See more
TPM4, Official Symbol TPM4provided by HGNC Official Full Name tropomyosin 4provided by HGNC Primary source HGNC:HGNC:12013 See related Ensembl:ENSG00000167460 MIM:600317; AllianceGenome:HGNC:12013 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BDPLT25; HEL-S-108 Summary This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] Expression Ubiquitous expression in gall bladder (RPKM 102.4), urinary bladder (RPKM 100.5) and 25 other tissues See more Orthologs mouse all
TPMT, Official Symbol TPMTprovided by HGNC Official Full Name thiopurine S-methyltransferaseprovided by HGNC Primary source HGNC:HGNC:12014 See related Ensembl:ENSG00000137364 MIM:187680; AllianceGenome:HGNC:12014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPMTD Summary This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014] Expression Broad expression in thyroid (RPKM 38.6), kidney (RPKM 27.8) and 24 other tissues See more Orthologs mouse all
TPMTP1, Official Symbol TPMTP1provided by HGNC Official Full Name thiopurine S-methyltransferase pseudogene 1provided by HGNC Primary source HGNC:HGNC:17490 See related AllianceGenome:HGNC:17490 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPMTP3, Official Symbol TPMTP3provided by HGNC Official Full Name thiopurine S-methyltransferase pseudogene 3provided by HGNC Primary source HGNC:HGNC:44566 See related Ensembl:ENSG00000232562 AllianceGenome:HGNC:44566 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPMTP4, Official Symbol TPMTP4provided by HGNC Official Full Name thiopurine S-methyltransferase pseudogene 4provided by HGNC Primary source HGNC:HGNC:44567 See related Ensembl:ENSG00000223574 AllianceGenome:HGNC:44567 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPO, Official Symbol TPOprovided by HGNC Official Full Name thyroid peroxidaseprovided by HGNC Primary source HGNC:HGNC:12015 See related Ensembl:ENSG00000115705 MIM:606765; AllianceGenome:HGNC:12015 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSA; TPX; TDH2A Summary This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011] Annotation information Note: TPO (Gene ID: 7173) and THPO (Gene ID: 7066) share the TPO symbol/alias in common. TPO is a widely used alternative name for thrombopoietin (THPO), which can be confused with the official symbol for TPO, thyroid peroxidase. [27 Jun 2018] Expression Restricted expression toward thyroid (RPKM 463.8) See more Orthologs mouse all
TPP1, Official Symbol TPP1provided by HGNC Official Full Name tripeptidyl peptidase 1provided by HGNC Primary source HGNC:HGNC:2073 See related Ensembl:ENSG00000166340 MIM:607998; AllianceGenome:HGNC:2073 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLN2; GIG1; LPIC; SCAR7; TPP-1 Summary This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008] Annotation information Note: TPP1 (Gene ID: 1200) and ACD (Gene ID: 65057) share the TPP1 symbol/alias in common. TPP1 is a widely used alternative name for ACD, shelterin complex subunit and telomerase recruitment factor (ACD), which can be confused with the official symbol for TPP1 (tripeptidyl peptidase 1, GeneID 1200). [01 Jun 2018] Expression Ubiquitous expression in spleen (RPKM 90.7), appendix (RPKM 64.1) and 25 other tissues See more Orthologs mouse all
TPP2, Official Symbol TPP2provided by HGNC Official Full Name tripeptidyl peptidase 2provided by HGNC Primary source HGNC:HGNC:12016 See related Ensembl:ENSG00000134900 MIM:190470; AllianceGenome:HGNC:12016 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMD78; TPP-2; TPPII; TPP-II Summary This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 15.8) and 25 other tissues See more Orthologs mouse all
TPPP, Official Symbol TPPPprovided by HGNC Official Full Name tubulin polymerization promoting proteinprovided by HGNC Primary source HGNC:HGNC:24164 See related Ensembl:ENSG00000171368 MIM:608773; AllianceGenome:HGNC:24164 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p24; p25; TPPP1; TPPP/p25; p25alpha Summary Enables several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including mitochondrion; mitotic spindle; and perinuclear region of cytoplasm. Colocalizes with microtubule and microtubule bundle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 45.7), lung (RPKM 7.7) and 9 other tissues See more Orthologs mouse all
TPPP2, Official Symbol TPPP2provided by HGNC Official Full Name tubulin polymerization promoting protein family member 2provided by HGNC Primary source HGNC:HGNC:19293 See related Ensembl:ENSG00000179636 MIM:616956; AllianceGenome:HGNC:19293 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P18; CT152; C14orf8; p25beta Summary Enables tubulin binding activity. Involved in regulation of flagellated sperm motility. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 37.8) and salivary gland (RPKM 2.8) See more Orthologs mouse all
TPPP3, Official Symbol TPPP3provided by HGNC Official Full Name tubulin polymerization promoting protein family member 3provided by HGNC Primary source HGNC:HGNC:24162 See related Ensembl:ENSG00000159713 MIM:616957; AllianceGenome:HGNC:24162 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p20; CGI-38; TPPP/p20; p25gamma Summary Enables tubulin binding activity. Involved in decidualization and microtubule bundle formation. Colocalizes with microtubule bundle and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in lung (RPKM 89.8), placenta (RPKM 51.0) and 18 other tissues See more Orthologs mouse all
TPR, Official Symbol TPRprovided by HGNC Official Full Name translocated promoter region, nuclear basket proteinprovided by HGNC Primary source HGNC:HGNC:12017 See related Ensembl:ENSG00000047410 MIM:189940; AllianceGenome:HGNC:12017 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRT79 Summary This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues See more Orthologs mouse all
TPRA1, Official Symbol TPRA1provided by HGNC Official Full Name transmembrane protein adipocyte associated 1provided by HGNC Primary source HGNC:HGNC:30413 See related Ensembl:ENSG00000163870 MIM:608336; AllianceGenome:HGNC:30413 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GPR175; TPRA40; TMEM227 Summary Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 7.3), endometrium (RPKM 6.7) and 25 other tissues See more Orthologs mouse all
TPRG1, Official Symbol TPRG1provided by HGNC Official Full Name tumor protein p63 regulated 1provided by HGNC Primary source HGNC:HGNC:24759 See related Ensembl:ENSG00000188001 AllianceGenome:HGNC:24759 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM79B Summary Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in esophagus (RPKM 2.6), skin (RPKM 1.9) and 7 other tissues See more Orthologs mouse all
TPRG1-AS1, Official Symbol TPRG1-AS1provided by HGNC Official Full Name TPRG1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:42391 See related AllianceGenome:HGNC:42391 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in liver (RPKM 7.5), fat (RPKM 4.9) and 8 other tissues See more
TPRG1-AS2, Official Symbol TPRG1-AS2provided by HGNC Official Full Name TPRG1 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:41062 See related Ensembl:ENSG00000230115 AllianceGenome:HGNC:41062 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in esophagus (RPKM 12.6), skin (RPKM 6.1) and 3 other tissues See more
TPRG1L, Official Symbol TPRG1Lprovided by HGNC Official Full Name tumor protein p63 regulated 1 likeprovided by HGNC Primary source HGNC:HGNC:27007 See related Ensembl:ENSG00000158109 MIM:611460; AllianceGenome:HGNC:27007 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPRGL; mover; FAM79A; SVAP30; h-mover Summary Predicted to enable identical protein binding activity. Predicted to be involved in regulation of glutamatergic synaptic transmission. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 35.5), kidney (RPKM 30.0) and 25 other tissues See more Orthologs mouse all
TPRG1LP1, Official Symbol TPRG1LP1provided by HGNC Official Full Name tumor protein p63 regulated 1 like pseudogene 1provided by HGNC Primary source HGNC:HGNC:52353 See related Ensembl:ENSG00000269097 AllianceGenome:HGNC:52353 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPRKB, Official Symbol TPRKBprovided by HGNC Official Full Name TP53RK binding proteinprovided by HGNC Primary source HGNC:HGNC:24259 See related Ensembl:ENSG00000144034 MIM:608680; AllianceGenome:HGNC:24259 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI121; GAMOS5; CGI-121 Summary Enables protein kinase binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytosol and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 5. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 8.1), colon (RPKM 6.1) and 25 other tissues See more Orthologs mouse all
TPRKBP1, Official Symbol TPRKBP1provided by HGNC Official Full Name TP53RK binding protein pseudogene 1provided by HGNC Primary source HGNC:HGNC:44943 See related Ensembl:ENSG00000231911 AllianceGenome:HGNC:44943 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPRKBP2, Official Symbol TPRKBP2provided by HGNC Official Full Name TP53RK binding protein pseudogene 2provided by HGNC Primary source HGNC:HGNC:44944 See related Ensembl:ENSG00000260452 AllianceGenome:HGNC:44944 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPRN, Official Symbol TPRNprovided by HGNC Official Full Name taperinprovided by HGNC Primary source HGNC:HGNC:26894 See related Ensembl:ENSG00000176058 MIM:613354; AllianceGenome:HGNC:26894 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DFNB79; C9orf75 Summary This locus encodes a sensory epithelial protein. It was defined by linkage analysis in three Pakistani families to lie between D9S1818 (centromeric) and D9SH6 (telomeric). Mutations at this locus have been associated with autosomal recessive deafness. [provided by RefSeq, Oct 2010] Expression Ubiquitous expression in colon (RPKM 6.8), small intestine (RPKM 4.8) and 25 other tissues See more Orthologs mouse all
TPRX1, Official Symbol TPRX1provided by HGNC Official Full Name tetrapeptide repeat homeobox 1provided by HGNC Primary source HGNC:HGNC:32174 See related Ensembl:ENSG00000178928 MIM:611166; AllianceGenome:HGNC:32174 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPRX Summary Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
TPRX1P1, Official Symbol TPRX1P1provided by HGNC Official Full Name tetrapeptide repeat homeobox 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:32176 See related AllianceGenome:HGNC:32176 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPRXP2 Summary Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]
TPRXL, Official Symbol TPRXLprovided by HGNC Official Full Name tetrapeptide repeat homeobox like (pseudogene)provided by HGNC Primary source HGNC:HGNC:32178 See related Ensembl:ENSG00000180438 MIM:611167; AllianceGenome:HGNC:32178 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPRX3P Summary Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008] Expression Biased expression in esophagus (RPKM 1.6), testis (RPKM 1.0) and 6 other tissues See more
TPSAB1, Official Symbol TPSAB1provided by HGNC Official Full Name tryptase alpha/beta 1provided by HGNC Primary source HGNC:HGNC:12019 See related Ensembl:ENSG00000172236 MIM:191080; AllianceGenome:HGNC:12019 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPS1; TPS2; TPSB1; TPSB2; Tryptase-2 Summary Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] Expression Biased expression in gall bladder (RPKM 111.8), lung (RPKM 108.7) and 13 other tissues See more Orthologs all
TPSB2, Official Symbol TPSB2provided by HGNC Official Full Name tryptase beta 2provided by HGNC Primary source HGNC:HGNC:14120 See related Ensembl:ENSG00000197253 MIM:191081; AllianceGenome:HGNC:14120 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPS2; tryptaseB; tryptaseC Summary Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Biased expression in gall bladder (RPKM 111.5), lung (RPKM 107.8) and 13 other tissues See more Orthologs all
TPSD1, Official Symbol TPSD1provided by HGNC Official Full Name tryptase delta 1provided by HGNC Primary source HGNC:HGNC:14118 See related Ensembl:ENSG00000095917 MIM:609272; AllianceGenome:HGNC:14118 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCP7L1; MMCP-7L; MCP7-LIKE Summary Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq, Jul 2008] Expression Biased expression in lung (RPKM 15.2), gall bladder (RPKM 13.3) and 13 other tissues See more Orthologs all
TPSG1, Official Symbol TPSG1provided by HGNC Official Full Name tryptase gamma 1provided by HGNC Primary source HGNC:HGNC:14134 See related Ensembl:ENSG00000116176 MIM:609341; AllianceGenome:HGNC:14134 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TMT; trpA; PRSS31 Summary Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] Expression Broad expression in colon (RPKM 7.2), endometrium (RPKM 6.9) and 18 other tissues See more Orthologs mouse all
TPSP2, Official Symbol TPSP2provided by HGNC Official Full Name tryptase pseudogene 2provided by HGNC Primary source HGNC:HGNC:14136 See related Ensembl:ENSG00000260284 AllianceGenome:HGNC:14136 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPST1, Official Symbol TPST1provided by HGNC Official Full Name tyrosylprotein sulfotransferase 1provided by HGNC Primary source HGNC:HGNC:12020 See related Ensembl:ENSG00000169902 MIM:603125; AllianceGenome:HGNC:12020 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TANGO13A Summary Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in gall bladder (RPKM 13.2), urinary bladder (RPKM 9.5) and 22 other tissues See more Orthologs mouse all
TPST2, Official Symbol TPST2provided by HGNC Official Full Name tyrosylprotein sulfotransferase 2provided by HGNC Primary source HGNC:HGNC:12021 See related Ensembl:ENSG00000128294 MIM:603126; AllianceGenome:HGNC:12021 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPST-2; TANGO13B Summary The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018] Expression Ubiquitous expression in pancreas (RPKM 24.6), placenta (RPKM 15.2) and 24 other tissues See more Orthologs mouse all
TPST2P1, Official Symbol TPST2P1provided by HGNC Official Full Name tyrosylprotein sulfotransferase 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44425 See related Ensembl:ENSG00000260582 AllianceGenome:HGNC:44425 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPT1, Official Symbol TPT1provided by HGNC Official Full Name tumor protein, translationally-controlled 1provided by HGNC Primary source HGNC:HGNC:12022 See related Ensembl:ENSG00000133112 MIM:600763; AllianceGenome:HGNC:12022 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HRF; p02; p23; TCTP Summary This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues See more Orthologs mouse all
TPT1P1, Official Symbol TPT1P1provided by HGNC Official Full Name TPT1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:16742 See related AllianceGenome:HGNC:16742 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPT1P
TPT1P3, Official Symbol TPT1P3provided by HGNC Official Full Name TPT1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:49295 See related Ensembl:ENSG00000241899 AllianceGenome:HGNC:49295 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPT1P5, Official Symbol TPT1P5provided by HGNC Official Full Name TPT1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:49296 See related Ensembl:ENSG00000214108 AllianceGenome:HGNC:49296 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPT1P7, Official Symbol TPT1P7provided by HGNC Official Full Name TPT1 pseudogene 7provided by HGNC Primary source HGNC:HGNC:49300 See related AllianceGenome:HGNC:49300 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPT1P9, Official Symbol TPT1P9provided by HGNC Official Full Name TPT1 pseudogene 9provided by HGNC Primary source HGNC:HGNC:49299 See related AllianceGenome:HGNC:49299 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
TPTE, Official Symbol TPTEprovided by HGNC Official Full Name transmembrane phosphatase with tensin homologyprovided by HGNC Primary source HGNC:HGNC:12023 See related Ensembl:ENSG00000274391 MIM:604336; AllianceGenome:HGNC:12023 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT44; PTEN2; TPTE1 Summary This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Restricted expression toward testis (RPKM 57.8) See more
TPTE2, Official Symbol TPTE2provided by HGNC Official Full Name transmembrane phosphoinositide 3-phosphatase and tensin homolog 2provided by HGNC Primary source HGNC:HGNC:17299 See related Ensembl:ENSG00000132958 MIM:606791; AllianceGenome:HGNC:17299 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TPIP Summary TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002] Expression Restricted expression toward testis (RPKM 4.7) See more Orthologs all
TPTE2P2, Official Symbol TPTE2P2provided by HGNC Official Full Name TPTE2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:38076 See related AllianceGenome:HGNC:38076 Gene type pseudo RefSeq status MODEL Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 2.9) See more
TPTE2P6, Official Symbol TPTE2P6provided by HGNC Official Full Name TPTE2 pseudogene 6provided by HGNC Primary source HGNC:HGNC:42644 See related AllianceGenome:HGNC:42644 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 2.3), endometrium (RPKM 0.5) and 5 other tissues See more
TPTEP2, Official Symbol TPTEP2provided by HGNC Official Full Name TPTE pseudogene 2provided by HGNC Primary source HGNC:HGNC:53828 See related AllianceGenome:HGNC:53828 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Z98749.2 Expression Ubiquitous expression in testis (RPKM 3.9), fat (RPKM 3.6) and 24 other tissues See more
TPTEP2-CSNK1E, Official Symbol TPTEP2-CSNK1Eprovided by HGNC Official Full Name TPTEP2-CSNK1E readthroughprovided by HGNC Primary source HGNC:HGNC:53829 See related Ensembl:ENSG00000283900 AllianceGenome:HGNC:53829 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LOC400927-CSNK1E Summary This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in endometrium (RPKM 31.3), brain (RPKM 31.3) and 25 other tissues See more Orthologs all
TPX2, Official Symbol TPX2provided by HGNC Official Full Name TPX2 microtubule nucleation factorprovided by HGNC Primary source HGNC:HGNC:1249 See related Ensembl:ENSG00000088325 MIM:605917; AllianceGenome:HGNC:1249 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1 Summary Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues See more Orthologs mouse all
TRA2A, Official Symbol TRA2Aprovided by HGNC Official Full Name transformer 2 alpha homologprovided by HGNC Primary source HGNC:HGNC:16645 See related Ensembl:ENSG00000164548 MIM:602718; AllianceGenome:HGNC:16645 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AWMS1; HSU53209 Summary This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in bone marrow (RPKM 46.2), endometrium (RPKM 25.7) and 25 other tissues See more Orthologs mouse all
TRA2B, Official Symbol TRA2Bprovided by HGNC Official Full Name transformer 2 beta homologprovided by HGNC Primary source HGNC:HGNC:10781 See related Ensembl:ENSG00000136527 MIM:602719; AllianceGenome:HGNC:10781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SFRS10; SRFS10; TRAN2B; PPP1R156; TRA2-BETA; Htra2-beta Summary This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in bone marrow (RPKM 41.9), lymph node (RPKM 15.3) and 25 other tissues See more Orthologs mouse all
TRABD, Official Symbol TRABDprovided by HGNC Official Full Name TraB domain containingprovided by HGNC Primary source HGNC:HGNC:28805 See related Ensembl:ENSG00000170638 AllianceGenome:HGNC:28805 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LP6054; PP2447 Expression Ubiquitous expression in bone marrow (RPKM 19.6), spleen (RPKM 13.4) and 25 other tissues See more Orthologs mouse all
TRABD2A, Official Symbol TRABD2Aprovided by HGNC Official Full Name TraB domain containing 2Aprovided by HGNC Primary source HGNC:HGNC:27013 See related Ensembl:ENSG00000186854 MIM:614912; AllianceGenome:HGNC:27013 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIKI1; C2orf89 Summary Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in negative regulation of Wnt signaling pathway and proteolysis. Is integral component of organelle membrane and integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in colon (RPKM 11.1), ovary (RPKM 8.7) and 9 other tissues See more Orthologs all