psui3905/ncbi_genes_summary huggingface dataset:
RGPD2, Official Symbol RGPD2provided by HGNC Official Full Name RANBP2 like and GRIP domain containing 2provided by HGNC Primary source HGNC:HGNC:32415 See related Ensembl:ENSG00000185304 MIM:612705; AllianceGenome:HGNC:32415 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGP2; NUP358; RANBP2L2 Summary Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 17.3), placenta (RPKM 6.4) and 23 other tissues See more
RGPD3, Official Symbol RGPD3provided by HGNC Official Full Name RANBP2 like and GRIP domain containing 3provided by HGNC Primary source HGNC:HGNC:32416 See related Ensembl:ENSG00000153165 MIM:612706; AllianceGenome:HGNC:32416 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGP3 Summary This gene is located in a cluster of Ran-binding protein related genes on chromosome 2 which arose through duplication in primates. The encoded protein contains an N-terminal TPR (tetratricopeptide repeat) domain, two Ran-binding domains, and a C-terminal GRIP domain (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain. [provided by RefSeq, Sep 2011] Expression Broad expression in testis (RPKM 22.2), thyroid (RPKM 6.7) and 25 other tissues See more
RGPD4, Official Symbol RGPD4provided by HGNC Official Full Name RANBP2 like and GRIP domain containing 4provided by HGNC Primary source HGNC:HGNC:32417 See related Ensembl:ENSG00000196862 MIM:612707; AllianceGenome:HGNC:32417 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGP4 Summary Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 18.2), thyroid (RPKM 5.7) and 25 other tissues See more Orthologs all
RGPD4-AS1, Official Symbol RGPD4-AS1provided by HGNC Official Full Name RGPD4 antisense RNA 1 (head to head)provided by HGNC Primary source HGNC:HGNC:49273 See related Ensembl:ENSG00000230651 AllianceGenome:HGNC:49273 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Restricted expression toward testis (RPKM 8.8) See more
RGPD5, Official Symbol RGPD5provided by HGNC Official Full Name RANBP2 like and GRIP domain containing 5provided by HGNC Primary source HGNC:HGNC:32418 See related Ensembl:ENSG00000015568 MIM:612708; AllianceGenome:HGNC:32418 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BS63; RGP5; BS-63; HEL161 Summary RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 33.7), brain (RPKM 11.6) and 25 other tissues See more
RGPD6, Official Symbol RGPD6provided by HGNC Official Full Name RANBP2 like and GRIP domain containing 6provided by HGNC Primary source HGNC:HGNC:32419 See related Ensembl:ENSG00000183054 MIM:612709; AllianceGenome:HGNC:32419 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGP6; RGPD7; RanBP2L1; RanBP2L2 Summary Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 24.0), brain (RPKM 8.3) and 25 other tissues See more
RGPD8, Official Symbol RGPD8provided by HGNC Official Full Name RANBP2 like and GRIP domain containing 8provided by HGNC Primary source HGNC:HGNC:9849 See related Ensembl:ENSG00000169629 MIM:602752; AllianceGenome:HGNC:9849 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGP8; RANBP2L1; RanBP2alpha Summary Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 26.7), brain (RPKM 9.2) and 25 other tissues See more Orthologs all
RGR, Official Symbol RGRprovided by HGNC Official Full Name retinal G protein coupled receptorprovided by HGNC Primary source HGNC:HGNC:9990 See related Ensembl:ENSG00000148604 MIM:600342; AllianceGenome:HGNC:9990 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP44 Summary This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 4.9) and testis (RPKM 0.4) See more Orthologs mouse all
RGS1, Official Symbol RGS1provided by HGNC Official Full Name regulator of G protein signaling 1provided by HGNC Primary source HGNC:HGNC:9991 See related Ensembl:ENSG00000090104 MIM:600323; AllianceGenome:HGNC:9991 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 1R20; BL34; IER1; IR20; HEL-S-87 Summary This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] Expression Broad expression in appendix (RPKM 110.9), lymph node (RPKM 72.3) and 17 other tissues See more Orthologs mouse all
RGS10, Official Symbol RGS10provided by HGNC Official Full Name regulator of G protein signaling 10provided by HGNC Primary source HGNC:HGNC:9992 See related Ensembl:ENSG00000148908 MIM:602856; AllianceGenome:HGNC:9992 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 32.4), appendix (RPKM 20.0) and 24 other tissues See more Orthologs mouse all
RGS11, Official Symbol RGS11provided by HGNC Official Full Name regulator of G protein signaling 11provided by HGNC Primary source HGNC:HGNC:9993 See related Ensembl:ENSG00000076344 MIM:603895; AllianceGenome:HGNC:9993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RS11 Summary The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013] Expression Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues See more Orthologs mouse all
RGS12, Official Symbol RGS12provided by HGNC Official Full Name regulator of G protein signaling 12provided by HGNC Primary source HGNC:HGNC:9994 See related Ensembl:ENSG00000159788 MIM:602512; AllianceGenome:HGNC:9994 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues See more Orthologs mouse all
RGS13, Official Symbol RGS13provided by HGNC Official Full Name regulator of G protein signaling 13provided by HGNC Primary source HGNC:HGNC:9995 See related Ensembl:ENSG00000127074 MIM:607190; AllianceGenome:HGNC:9995 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues See more Orthologs mouse all
RGS14, Official Symbol RGS14provided by HGNC Official Full Name regulator of G protein signaling 14provided by HGNC Primary source HGNC:HGNC:9996 See related Ensembl:ENSG00000169220 MIM:602513; AllianceGenome:HGNC:9996 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 15.0), lymph node (RPKM 11.5) and 23 other tissues See more Orthologs mouse all
RGS16, Official Symbol RGS16provided by HGNC Official Full Name regulator of G protein signaling 16provided by HGNC Primary source HGNC:HGNC:9997 See related Ensembl:ENSG00000143333 MIM:602514; AllianceGenome:HGNC:9997 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGS-R; A28-RGS14; A28-RGS14P Summary The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008] Expression Biased expression in thyroid (RPKM 20.2), lung (RPKM 3.6) and 11 other tissues See more Orthologs mouse all
RGS17, Official Symbol RGS17provided by HGNC Official Full Name regulator of G protein signaling 17provided by HGNC Primary source HGNC:HGNC:14088 See related Ensembl:ENSG00000091844 MIM:607191; AllianceGenome:HGNC:14088 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGSZ2; RGS-17; hRGS17 Summary This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 1.8), brain (RPKM 1.6) and 17 other tissues See more Orthologs mouse all
RGS18, Official Symbol RGS18provided by HGNC Official Full Name regulator of G protein signaling 18provided by HGNC Primary source HGNC:HGNC:14261 See related Ensembl:ENSG00000150681 MIM:607192; AllianceGenome:HGNC:14261 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGS13 Summary This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 9.4), appendix (RPKM 6.5) and 15 other tissues See more Orthologs mouse all
RGS19, Official Symbol RGS19provided by HGNC Official Full Name regulator of G protein signaling 19provided by HGNC Primary source HGNC:HGNC:13735 See related Ensembl:ENSG00000171700 MIM:605071; AllianceGenome:HGNC:13735 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAIP; RGSGAIP Summary G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more Orthologs mouse all
RGS2, Official Symbol RGS2provided by HGNC Official Full Name regulator of G protein signaling 2provided by HGNC Primary source HGNC:HGNC:9998 See related Ensembl:ENSG00000116741 MIM:600861; AllianceGenome:HGNC:9998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G0S8 Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009] Expression Broad expression in bone marrow (RPKM 211.2), adrenal (RPKM 208.4) and 20 other tissues See more Orthologs mouse all
RGS20, Official Symbol RGS20provided by HGNC Official Full Name regulator of G protein signaling 20provided by HGNC Primary source HGNC:HGNC:14600 See related Ensembl:ENSG00000147509 MIM:607193; AllianceGenome:HGNC:14600 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGSZ1; ZGAP1; gz-GAP; g(z)GAP Summary The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Biased expression in brain (RPKM 2.5), thyroid (RPKM 0.6) and 3 other tissues See more Orthologs mouse all
RGS21, Official Symbol RGS21provided by HGNC Official Full Name regulator of G protein signaling 21provided by HGNC Primary source HGNC:HGNC:26839 See related Ensembl:ENSG00000253148 MIM:612407; AllianceGenome:HGNC:26839 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
RGS22, Official Symbol RGS22provided by HGNC Official Full Name regulator of G protein signaling 22provided by HGNC Primary source HGNC:HGNC:24499 See related Ensembl:ENSG00000132554 MIM:615650; AllianceGenome:HGNC:24499 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CT145; PRTD-NY2 Summary Enables G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in actin cytoskeleton; cytosol; and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 35.2), ovary (RPKM 3.9) and 1 other tissue See more Orthologs mouse all
RGS3, Official Symbol RGS3provided by HGNC Official Full Name regulator of G protein signaling 3provided by HGNC Primary source HGNC:HGNC:9999 See related Ensembl:ENSG00000138835 MIM:602189; AllianceGenome:HGNC:9999 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2PA; RGP3 Summary This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in heart (RPKM 8.0), fat (RPKM 4.2) and 24 other tissues See more Orthologs mouse all
RGS4, Official Symbol RGS4provided by HGNC Official Full Name regulator of G protein signaling 4provided by HGNC Primary source HGNC:HGNC:10000 See related Ensembl:ENSG00000117152 MIM:602516; AllianceGenome:HGNC:10000 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGP4; SCZD9 Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue See more Orthologs mouse all
RGS5, Official Symbol RGS5provided by HGNC Official Full Name regulator of G protein signaling 5provided by HGNC Primary source HGNC:HGNC:10001 See related Ensembl:ENSG00000143248 MIM:603276; AllianceGenome:HGNC:10001 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129 Summary This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022] Expression Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues See more Orthologs mouse all
RGS5-AS1, Official Symbol RGS5-AS1provided by HGNC Official Full Name RGS5 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40504 See related Ensembl:ENSG00000232892 AllianceGenome:HGNC:40504 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
RGS6, Official Symbol RGS6provided by HGNC Official Full Name regulator of G protein signaling 6provided by HGNC Primary source HGNC:HGNC:10002 See related Ensembl:ENSG00000182732 MIM:603894; AllianceGenome:HGNC:10002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAP; S914; HA117 Summary This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
RGS7, Official Symbol RGS7provided by HGNC Official Full Name regulator of G protein signaling 7provided by HGNC Primary source HGNC:HGNC:10003 See related Ensembl:ENSG00000182901 MIM:602517; AllianceGenome:HGNC:10003 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables G-protein beta-subunit binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 5.9), adrenal (RPKM 1.5) and 2 other tissues See more Orthologs mouse all
RGS7BP, Official Symbol RGS7BPprovided by HGNC Official Full Name regulator of G protein signaling 7 binding proteinprovided by HGNC Primary source HGNC:HGNC:23271 See related Ensembl:ENSG00000186479 MIM:610890; AllianceGenome:HGNC:23271 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R7BP Summary This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012] Expression Biased expression in brain (RPKM 14.8), prostate (RPKM 2.8) and 9 other tissues See more Orthologs mouse all
RGS8, Official Symbol RGS8provided by HGNC Official Full Name regulator of G protein signaling 8provided by HGNC Primary source HGNC:HGNC:16810 See related Ensembl:ENSG00000135824 MIM:607189; AllianceGenome:HGNC:16810 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008] Expression Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues See more Orthologs mouse all
RGS9, Official Symbol RGS9provided by HGNC Official Full Name regulator of G protein signaling 9provided by HGNC Primary source HGNC:HGNC:10004 See related Ensembl:ENSG00000108370 MIM:604067; AllianceGenome:HGNC:10004 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PERRS; RGS9L; PERRS1 Summary This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] Expression Ubiquitous expression in brain (RPKM 1.6), lung (RPKM 1.2) and 24 other tissues See more Orthologs mouse all
RGS9BP, Official Symbol RGS9BPprovided by HGNC Official Full Name regulator of G protein signaling 9 binding proteinprovided by HGNC Primary source HGNC:HGNC:30304 See related Ensembl:ENSG00000186326 MIM:607814; AllianceGenome:HGNC:30304 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R9AP; RGS9; PERRS; PERRS2 Summary The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010] Orthologs mouse all
RGSL1, Official Symbol RGSL1provided by HGNC Official Full Name regulator of G protein signaling like 1provided by HGNC Primary source HGNC:HGNC:18636 See related Ensembl:ENSG00000121446 MIM:611012; AllianceGenome:HGNC:18636 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RGSL; RGSL2 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 3.0) See more Orthologs mouse all
RHAG, Official Symbol RHAGprovided by HGNC Official Full Name Rh associated glycoproteinprovided by HGNC Primary source HGNC:HGNC:10006 See related Ensembl:ENSG00000112077 MIM:180297; AllianceGenome:HGNC:10006 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OHS; RH2; OHST; RHNR; Rh50; CD241; RH50A; Rh50GP; SLC42A1 Summary The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009] Expression Restricted expression toward bone marrow (RPKM 40.5) See more Orthologs mouse all
RHBDD1, Official Symbol RHBDD1provided by HGNC Official Full Name rhomboid domain containing 1provided by HGNC Primary source HGNC:HGNC:23081 See related Ensembl:ENSG00000144468 MIM:617515; AllianceGenome:HGNC:23081 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RRP4; RHBDL4 Summary Enables serine-type endopeptidase activity. Involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 3.8), thyroid (RPKM 3.6) and 25 other tissues See more Orthologs mouse all
RHBDD2, Official Symbol RHBDD2provided by HGNC Official Full Name rhomboid domain containing 2provided by HGNC Primary source HGNC:HGNC:23082 See related Ensembl:ENSG00000005486 MIM:615203; AllianceGenome:HGNC:23082 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NPD007; RHBDL7 Summary The protein encoded by this gene is a member of the rhomboid family of membrane-bound proteases and is overexpressed in some breast cancers. Members of this family are involved in intramembrane proteolysis. In mouse, the orthologous protein associates with the Golgi body. [provided by RefSeq, Sep 2016] Expression Ubiquitous expression in brain (RPKM 72.8), adrenal (RPKM 57.9) and 25 other tissues See more Orthologs mouse all
RHBDD3, Official Symbol RHBDD3provided by HGNC Official Full Name rhomboid domain containing 3provided by HGNC Primary source HGNC:HGNC:1308 See related Ensembl:ENSG00000100263 AllianceGenome:HGNC:1308 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTAG; C22orf3; HS984G1A Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including liver development; negative regulation of natural killer cell activation; and positive regulation of protein catabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 5.8), prostate (RPKM 4.1) and 25 other tissues See more Orthologs mouse all
RHBDF1, Official Symbol RHBDF1provided by HGNC Official Full Name rhomboid 5 homolog 1provided by HGNC Primary source HGNC:HGNC:20561 See related Ensembl:ENSG00000007384 MIM:614403; AllianceGenome:HGNC:20561 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Dist1; hDist1; C16orf8; EGFR-RS; gene-89; gene-90 Summary Predicted to enable growth factor binding activity and serine-type endopeptidase activity. Involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in placenta (RPKM 12.8), prostate (RPKM 9.9) and 24 other tissues See more Orthologs mouse all
RHBDF1P1, Official Symbol RHBDF1P1provided by HGNC Official Full Name RHBDF1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:44499 See related Ensembl:ENSG00000234123 AllianceGenome:HGNC:44499 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
RHBDF2, Official Symbol RHBDF2provided by HGNC Official Full Name rhomboid 5 homolog 2provided by HGNC Primary source HGNC:HGNC:20788 See related Ensembl:ENSG00000129667 MIM:614404; AllianceGenome:HGNC:20788 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOC; TOCG; RHBDL5; RHBDL6; iRhom2 Summary Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 8.7), appendix (RPKM 7.3) and 25 other tissues See more Orthologs mouse all
RHBDL1, Official Symbol RHBDL1provided by HGNC Official Full Name rhomboid like 1provided by HGNC Primary source HGNC:HGNC:10007 See related Ensembl:ENSG00000103269 MIM:603264; AllianceGenome:HGNC:10007 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RRP; RHBDL Summary This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] Expression Broad expression in brain (RPKM 2.4), kidney (RPKM 1.5) and 21 other tissues See more Orthologs mouse all
RHBDL2, Official Symbol RHBDL2provided by HGNC Official Full Name rhomboid like 2provided by HGNC Primary source HGNC:HGNC:16083 See related Ensembl:ENSG00000158315 MIM:608962; AllianceGenome:HGNC:16083 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RRP2 Summary The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] Expression Biased expression in colon (RPKM 9.9), skin (RPKM 6.4) and 10 other tissues See more Orthologs mouse all
RHBDL3, Official Symbol RHBDL3provided by HGNC Official Full Name rhomboid like 3provided by HGNC Primary source HGNC:HGNC:16502 See related Ensembl:ENSG00000141314 MIM:619017; AllianceGenome:HGNC:16502 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as VRHO; RHBDL4 Summary Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 5.3), adrenal (RPKM 1.6) and 5 other tissues See more Orthologs mouse all
RHBG, Official Symbol RHBGprovided by HGNC Official Full Name Rh family B glycoproteinprovided by HGNC Primary source HGNC:HGNC:14572 See related Ensembl:ENSG00000132677 MIM:607079; AllianceGenome:HGNC:14572 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLC42A2 Summary This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] Expression Biased expression in kidney (RPKM 4.7), ovary (RPKM 3.9) and 5 other tissues See more Orthologs mouse all
RHCE, Official Symbol RHCEprovided by HGNC Official Full Name Rh blood group CcEe antigensprovided by HGNC Primary source HGNC:HGNC:10008 See related Ensembl:ENSG00000188672 MIM:111700; AllianceGenome:HGNC:10008 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RH; RHC; RHE; Rh4; RHNA; RHPI; RhVI; RH30A; RHIXB; RhVIII; CD240CE; RhIVb(J); RHCe(152N) Summary The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Aug 2016] Expression Biased expression in bone marrow (RPKM 11.4), prostate (RPKM 0.7) and 2 other tissues See more Orthologs all
RHCG, Official Symbol RHCGprovided by HGNC Official Full Name Rh family C glycoproteinprovided by HGNC Primary source HGNC:HGNC:18140 See related Ensembl:ENSG00000140519 MIM:605381; AllianceGenome:HGNC:18140 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RHGK; PDRC2; C15orf6; SLC42A3 Summary Enables ammonium transmembrane transporter activity; ankyrin binding activity; and identical protein binding activity. Involved in ammonium transmembrane transport; cellular ion homeostasis; and transepithelial ammonium transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward esophagus (RPKM 1491.4) See more Orthologs mouse all