psui3905/ncbi_genes_summary huggingface dataset:
FH, Official Symbol FHprovided by HGNC Official Full Name fumarate hydrataseprovided by HGNC Primary source HGNC:HGNC:3700 See related Ensembl:ENSG00000091483 MIM:136850; AllianceGenome:HGNC:3700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCL; FMRD; HsFH; LRCC; HLRCC; MCUL1 Summary The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in heart (RPKM 49.3), liver (RPKM 41.8) and 25 other tissues See more Orthologs mouse all
FHAD1, Official Symbol FHAD1provided by HGNC Official Full Name forkhead associated phosphopeptide binding domain 1provided by HGNC Primary source HGNC:HGNC:29408 See related Ensembl:ENSG00000142621 AllianceGenome:HGNC:29408 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 6.7), lung (RPKM 1.0) and 1 other tissue See more Orthologs mouse all
FHAD1-AS1, Official Symbol FHAD1-AS1provided by HGNC Official Full Name FHAD1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41241 See related Ensembl:ENSG00000233485 AllianceGenome:HGNC:41241 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in adrenal (RPKM 2.4), testis (RPKM 2.4) and 11 other tissues See more
FHDC1, Official Symbol FHDC1provided by HGNC Official Full Name FH2 domain containing 1provided by HGNC Primary source HGNC:HGNC:29363 See related Ensembl:ENSG00000137460 MIM:620268; AllianceGenome:HGNC:29363 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INF1 Summary Predicted to enable actin binding activity and microtubule binding activity. Involved in Golgi ribbon formation; cilium assembly; and stress fiber assembly. Located in cilium and microtubule. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.7), prostate (RPKM 5.1) and 24 other tissues See more Orthologs mouse all
FHIP1B, Official Symbol FHIP1Bprovided by HGNC Official Full Name FHF complex subunit HOOK interacting protein 1Bprovided by HGNC Primary source HGNC:HGNC:25378 See related Ensembl:ENSG00000051009 MIM:620229; AllianceGenome:HGNC:25378 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHIP; C11orf56; FAM160A2 Summary The protein encoded by this gene is part of the FTS/Hook/FHIP (FHF) complex, which can interact with members of the homotypic vesicular protein sorting (HOPS) complex. This interaction suggests that the encoded protein is involved in vesicle trafficking. [provided by RefSeq, Dec 2016] Expression Ubiquitous expression in small intestine (RPKM 16.8), duodenum (RPKM 16.4) and 25 other tissues See more Orthologs mouse all
FHIT, Official Symbol FHITprovided by HGNC Official Full Name fragile histidine triad diadenosine triphosphataseprovided by HGNC Primary source HGNC:HGNC:3701 See related Ensembl:ENSG00000189283 MIM:601153; AllianceGenome:HGNC:3701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FRA3B; AP3Aase Summary The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in gall bladder (RPKM 2.2), lymph node (RPKM 1.6) and 25 other tissues See more Orthologs mouse all
FHL1, Official Symbol FHL1provided by HGNC Official Full Name four and a half LIM domains 1provided by HGNC Primary source HGNC:HGNC:3702 See related Ensembl:ENSG00000022267 MIM:300163; AllianceGenome:HGNC:3702 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KYOT; SLIM; FCMSU; FHL-1; FHL1A; FHL1B; FLH1A; SLIM1; XMPMA; RBMX1A; RBMX1B; SLIM-1; SLIMMER Summary This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009] Expression Broad expression in heart (RPKM 286.6), fat (RPKM 281.6) and 18 other tissues See more Orthologs mouse all
FHL2, Official Symbol FHL2provided by HGNC Official Full Name four and a half LIM domains 2provided by HGNC Primary source HGNC:HGNC:3703 See related Ensembl:ENSG00000115641 MIM:602633; AllianceGenome:HGNC:3703 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DRAL; AAG11; FHL-2; SLIM3; SLIM-3 Summary This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016] Expression Biased expression in heart (RPKM 149.2), ovary (RPKM 139.8) and 13 other tissues See more Orthologs mouse all
FHL3, Official Symbol FHL3provided by HGNC Official Full Name four and a half LIM domains 3provided by HGNC Primary source HGNC:HGNC:3704 See related Ensembl:ENSG00000183386 MIM:602790; AllianceGenome:HGNC:3704 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLIM2 Summary The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in esophagus (RPKM 21.3), endometrium (RPKM 16.8) and 25 other tissues See more Orthologs mouse all
FHL5, Official Symbol FHL5provided by HGNC Official Full Name four and a half LIM domains 5provided by HGNC Primary source HGNC:HGNC:17371 See related Ensembl:ENSG00000112214 MIM:605126; AllianceGenome:HGNC:17371 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACT; FHL-5; dJ393D12.2; 1700027G07Rik Summary The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016] Expression Broad expression in testis (RPKM 16.0), fat (RPKM 12.3) and 18 other tissues See more Orthologs mouse all
FHOD1, Official Symbol FHOD1provided by HGNC Official Full Name formin homology 2 domain containing 1provided by HGNC Primary source HGNC:HGNC:17905 See related Ensembl:ENSG00000135723 MIM:606881; AllianceGenome:HGNC:17905 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FHOS Summary This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Broad expression in spleen (RPKM 38.0), lung (RPKM 13.5) and 20 other tissues See more Orthologs mouse all
FHOD3, Official Symbol FHOD3provided by HGNC Official Full Name formin homology 2 domain containing 3provided by HGNC Primary source HGNC:HGNC:26178 See related Ensembl:ENSG00000134775 MIM:609691; AllianceGenome:HGNC:26178 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMH28; FHOS2; Formactin2 Summary The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015] Expression Biased expression in heart (RPKM 23.5), prostate (RPKM 6.1) and 10 other tissues See more Orthologs mouse all
FHP1, Official Symbol FHP1provided by HGNC Official Full Name fumarate hydratase pseudogene 1provided by HGNC Primary source HGNC:HGNC:39442 See related Ensembl:ENSG00000234213 AllianceGenome:HGNC:39442 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FIBCD1, Official Symbol FIBCD1provided by HGNC Official Full Name fibrinogen C domain containing 1provided by HGNC Primary source HGNC:HGNC:25922 See related Ensembl:ENSG00000130720 MIM:613357; AllianceGenome:HGNC:25922 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010] Expression Biased expression in testis (RPKM 2.4), adrenal (RPKM 1.6) and 6 other tissues See more Orthologs mouse all
FIBIN, Official Symbol FIBINprovided by HGNC Official Full Name fin bud initiation factor homologprovided by HGNC Primary source HGNC:HGNC:33747 See related Ensembl:ENSG00000176971 MIM:617085; AllianceGenome:HGNC:33747 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable protein homodimerization activity. Predicted to act upstream of or within protein kinase C signaling; response to dexamethasone; and response to manganese ion. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
FIBP, Official Symbol FIBPprovided by HGNC Official Full Name FGF1 intracellular binding proteinprovided by HGNC Primary source HGNC:HGNC:3705 See related Ensembl:ENSG00000172500 MIM:608296; AllianceGenome:HGNC:3705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FGFIBP; FIBP-1; TROFAS Summary Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 27.1), brain (RPKM 21.5) and 25 other tissues See more Orthologs mouse all
FICD, Official Symbol FICDprovided by HGNC Official Full Name FIC domain protein adenylyltransferaseprovided by HGNC Primary source HGNC:HGNC:18416 See related Ensembl:ENSG00000198855 AllianceGenome:HGNC:18416 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYPE; HIP13; UNQ3041 Summary Enables several functions, including ATP binding activity; Hsp70 protein binding activity; and chaperone binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 7.5), testis (RPKM 4.5) and 25 other tissues See more Orthologs mouse all
FIG4, Official Symbol FIG4provided by HGNC Official Full Name FIG4 phosphoinositide 5-phosphataseprovided by HGNC Primary source HGNC:HGNC:16873 See related Ensembl:ENSG00000112367 MIM:609390; AllianceGenome:HGNC:16873 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BOP; YVS; BTOP; SAC3; ALS11; CMT4J; KIAA0274; dJ249I4.1 Summary The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 6.2), lung (RPKM 4.8) and 25 other tissues See more Orthologs mouse all
FIGLA, Official Symbol FIGLAprovided by HGNC Official Full Name folliculogenesis specific bHLH transcription factorprovided by HGNC Primary source HGNC:HGNC:24669 See related Ensembl:ENSG00000183733 MIM:608697; AllianceGenome:HGNC:24669 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as POF6; BHLHC8; FIGALPHA Summary This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009] Expression Low expression observed in reference dataset See more Orthologs mouse all
FIGN, Official Symbol FIGNprovided by HGNC Official Full Name fidgetin, microtubule severing factorprovided by HGNC Primary source HGNC:HGNC:13285 See related Ensembl:ENSG00000182263 MIM:605295; AllianceGenome:HGNC:13285 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to act upstream of or within locomotory behavior. Predicted to be located in nuclear matrix. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 1.1), fat (RPKM 1.0) and 25 other tissues See more Orthologs mouse all
FIGNL1, Official Symbol FIGNL1provided by HGNC Official Full Name fidgetin like 1provided by HGNC Primary source HGNC:HGNC:13286 See related Ensembl:ENSG00000132436 MIM:615383; AllianceGenome:HGNC:13286 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016] Expression Ubiquitous expression in lymph node (RPKM 1.9), appendix (RPKM 1.8) and 24 other tissues See more Orthologs mouse all
FIGNL2, Official Symbol FIGNL2provided by HGNC Official Full Name fidgetin like 2provided by HGNC Primary source HGNC:HGNC:13287 See related Ensembl:ENSG00000261308 AllianceGenome:HGNC:13287 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in kidney (RPKM 1.7), testis (RPKM 0.4) and 15 other tissues See more Orthologs mouse all
FIGNL2-DT, Official Symbol FIGNL2-DTprovided by HGNC Official Full Name FIGNL2 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53299 See related Ensembl:ENSG00000259887 AllianceGenome:HGNC:53299 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FILIP1, Official Symbol FILIP1provided by HGNC Official Full Name filamin A interacting protein 1provided by HGNC Primary source HGNC:HGNC:21015 See related Ensembl:ENSG00000118407 MIM:607307; AllianceGenome:HGNC:21015 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FILIP Summary This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016] Expression Biased expression in heart (RPKM 16.2), esophagus (RPKM 4.3) and 12 other tissues See more Orthologs mouse all
FILIP1L, Official Symbol FILIP1Lprovided by HGNC Official Full Name filamin A interacting protein 1 likeprovided by HGNC Primary source HGNC:HGNC:24589 See related Ensembl:ENSG00000168386 MIM:612993; AllianceGenome:HGNC:24589 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOC1; DOC-1; GIP90; GIP130 Summary Predicted to be located in cytoplasm; membrane; and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 44.5), urinary bladder (RPKM 29.8) and 23 other tissues See more Orthologs mouse all
FILNC1, Official Symbol FILNC1provided by HGNC Official Full Name FOXO induced long non-coding RNA 1provided by HGNC Primary source HGNC:HGNC:53755 See related Ensembl:ENSG00000231426 AllianceGenome:HGNC:53755 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene produces a long non-coding RNA that is induced by forkhead box O proteins and plays a role in stress-induced apoptosis. Knock down of transcripts at this locus results in increased renal tumor growth and alteration in genes involved in glucose metabolism. This RNA interacts with heterogeneous nuclear ribonucleoprotein D and prevents it from binding to Myc mRNA, therefore suppressing Myc activity. Alternative splicing and transcriptional start site usage results in multiple transcript variants. [provided by RefSeq, Oct 2017] Expression Low expression observed in reference dataset See more
FIP1L1, Official Symbol FIP1L1provided by HGNC Official Full Name factor interacting with PAPOLA and CPSF1provided by HGNC Primary source HGNC:HGNC:19124 See related Ensembl:ENSG00000145216 MIM:607686; AllianceGenome:HGNC:19124 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Rhe; FIP1; hFip1 Summary This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in testis (RPKM 13.3), brain (RPKM 11.1) and 25 other tissues See more Orthologs mouse all
FIRRE, Official Symbol FIRREprovided by HGNC Official Full Name firre intergenic repeating RNA elementprovided by HGNC Primary source HGNC:HGNC:49627 See related Ensembl:ENSG00000213468 MIM:300999; AllianceGenome:HGNC:49627 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01200 Summary This gene produces a long RNA containing a repeating sequence. This RNA interacts with heterogeneous nuclear ribonucleoprotein U and coats chromosomes, where it plays an important role in the maintenance of repressive chromatin. This transcript can also act post-transcriptionally to regulate the stability of mRNAs during the innate immune response. [provided by RefSeq, Dec 2017] Expression Low expression observed in reference dataset See more Orthologs mouse all
FIRRM, Official Symbol FIRRMprovided by HGNC Official Full Name FIGNL1 interacting regulator of recombination and mitosisprovided by HGNC Primary source HGNC:HGNC:25565 See related Ensembl:ENSG00000000460 AllianceGenome:HGNC:25565 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FLIP; Apolo1; MEICA1; C1orf112 Expression Ubiquitous expression in testis (RPKM 5.7), lymph node (RPKM 3.2) and 24 other tissues See more Orthologs mouse all
FIS1, Official Symbol FIS1provided by HGNC Official Full Name fission, mitochondrial 1provided by HGNC Primary source HGNC:HGNC:21689 See related Ensembl:ENSG00000214253 MIM:609003; AllianceGenome:HGNC:21689 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TTC11; CGI-135 Summary Enables identical protein binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular calcium ion homeostasis; and mitochondrion organization. Acts upstream of or within mitochondrion morphogenesis. Located in mitochondrion and peroxisome. Is integral component of mitochondrial outer membrane and integral component of peroxisomal membrane. Part of protein-containing complex. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 77.0), thyroid (RPKM 71.6) and 25 other tissues See more Orthologs mouse all
FITM1, Official Symbol FITM1provided by HGNC Official Full Name fat storage inducing transmembrane protein 1provided by HGNC Primary source HGNC:HGNC:33714 See related Ensembl:ENSG00000139914 MIM:612028; AllianceGenome:HGNC:33714 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIT1 Summary Predicted to enable diacylglycerol binding activity and triglyceride binding activity. Predicted to be involved in lipid droplet formation; phospholipid biosynthetic process; and positive regulation of sequestering of triglyceride. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in heart (RPKM 28.4), prostate (RPKM 3.1) and 3 other tissues See more Orthologs mouse all
FITM2, Official Symbol FITM2provided by HGNC Official Full Name fat storage inducing transmembrane protein 2provided by HGNC Primary source HGNC:HGNC:16135 See related Ensembl:ENSG00000197296 MIM:612029; AllianceGenome:HGNC:16135 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Fit2; SIDDIS; C20orf142; dJ881L22.2 Summary Enables CoA pyrophosphatase activity. Involved in several processes, including fatty-acyl-CoA catabolic process; lipid droplet formation; and lipid homeostasis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in heart (RPKM 23.3), fat (RPKM 9.0) and 21 other tissues See more Orthologs mouse all
FIZ1, Official Symbol FIZ1provided by HGNC Official Full Name FLT3 interacting zinc finger 1provided by HGNC Primary source HGNC:HGNC:25917 See related Ensembl:ENSG00000179943 MIM:609133; AllianceGenome:HGNC:25917 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ZNF798 Summary This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 2.2), brain (RPKM 1.9) and 25 other tissues See more Orthologs mouse all
FJX1, Official Symbol FJX1provided by HGNC Official Full Name four-jointed box kinase 1provided by HGNC Primary source HGNC:HGNC:17166 See related Ensembl:ENSG00000179431 MIM:612206; AllianceGenome:HGNC:17166 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. [provided by RefSeq, Jul 2008] Orthologs mouse all
FKBP10, Official Symbol FKBP10provided by HGNC Official Full Name FKBP prolyl isomerase 10provided by HGNC Primary source HGNC:HGNC:18169 See related Ensembl:ENSG00000141756 MIM:607063; AllianceGenome:HGNC:18169 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OI6; BRKS; OI11; TLH1; BRKS1; FKBP65; PPIASE; hFKBP65 Summary The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009] Expression Ubiquitous expression in placenta (RPKM 31.0), endometrium (RPKM 25.7) and 22 other tissues See more Orthologs mouse all
FKBP11, Official Symbol FKBP11provided by HGNC Official Full Name FKBP prolyl isomerase 11provided by HGNC Primary source HGNC:HGNC:18624 See related Ensembl:ENSG00000134285 MIM:610571; AllianceGenome:HGNC:18624 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP19 Summary FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in pancreas (RPKM 27.0), appendix (RPKM 17.8) and 24 other tissues See more Orthologs mouse all
FKBP14, Official Symbol FKBP14provided by HGNC Official Full Name FKBP prolyl isomerase 14provided by HGNC Primary source HGNC:HGNC:18625 See related Ensembl:ENSG00000106080 MIM:614505; AllianceGenome:HGNC:18625 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDSKMH; FKBP22; IPBP12; EDSKSCL2 Summary The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012] Expression Ubiquitous expression in endometrium (RPKM 5.0), urinary bladder (RPKM 4.2) and 24 other tissues See more Orthologs mouse all
FKBP14-AS1, Official Symbol FKBP14-AS1provided by HGNC Official Full Name FKBP14 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40990 See related AllianceGenome:HGNC:40990 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
FKBP15, Official Symbol FKBP15provided by HGNC Official Full Name FKBP prolyl isomerase family member 15provided by HGNC Primary source HGNC:HGNC:23397 See related Ensembl:ENSG00000119321 MIM:617398; AllianceGenome:HGNC:23397 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP133; PPP1R76; KIAA0674 Summary Predicted to enable actin binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in endocytosis and protein peptidyl-prolyl isomerization. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 13.2), appendix (RPKM 13.2) and 25 other tissues See more Orthologs mouse all
FKBP1A, Official Symbol FKBP1Aprovided by HGNC Official Full Name FKBP prolyl isomerase 1Aprovided by HGNC Primary source HGNC:HGNC:3711 See related Ensembl:ENSG00000088832 MIM:186945; AllianceGenome:HGNC:3711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in placenta (RPKM 88.0), thyroid (RPKM 87.6) and 25 other tissues See more Orthologs mouse all
FKBP1B, Official Symbol FKBP1Bprovided by HGNC Official Full Name FKBP prolyl isomerase 1Bprovided by HGNC Primary source HGNC:HGNC:3712 See related Ensembl:ENSG00000119782 MIM:600620; AllianceGenome:HGNC:3712 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6 Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in duodenum (RPKM 4.2), brain (RPKM 2.6) and 25 other tissues See more Orthologs mouse all
FKBP1C, Official Symbol FKBP1Cprovided by HGNC Official Full Name FKBP prolyl isomerase family member 1Cprovided by HGNC Primary source HGNC:HGNC:21376 See related Ensembl:ENSG00000198225 AllianceGenome:HGNC:21376 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
FKBP2, Official Symbol FKBP2provided by HGNC Official Full Name FKBP prolyl isomerase 2provided by HGNC Primary source HGNC:HGNC:3718 See related Ensembl:ENSG00000173486 MIM:186946; AllianceGenome:HGNC:3718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP13; PPIase; FKBP-13 Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in kidney (RPKM 33.5), thyroid (RPKM 33.5) and 25 other tissues See more Orthologs mouse all
FKBP3, Official Symbol FKBP3provided by HGNC Official Full Name FKBP prolyl isomerase 3provided by HGNC Primary source HGNC:HGNC:3719 See related Ensembl:ENSG00000100442 MIM:186947; AllianceGenome:HGNC:3719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP-3; FKBP25; PPIase; FKBP-25 Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues See more Orthologs mouse all
FKBP4, Official Symbol FKBP4provided by HGNC Official Full Name FKBP prolyl isomerase 4provided by HGNC Primary source HGNC:HGNC:3720 See related Ensembl:ENSG00000004478 MIM:600611; AllianceGenome:HGNC:3720 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008] Expression Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 21.3) and 25 other tissues See more Orthologs mouse all
FKBP4P2, Official Symbol FKBP4P2provided by HGNC Official Full Name FKBP prolyl isomerase 4 pseudogene 2provided by HGNC Primary source HGNC:HGNC:50371 See related Ensembl:ENSG00000269692 AllianceGenome:HGNC:50371 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FKBP4P6, Official Symbol FKBP4P6provided by HGNC Official Full Name FKBP prolyl isomerase 4 pseudogene 6provided by HGNC Primary source HGNC:HGNC:50375 See related Ensembl:ENSG00000268234 AllianceGenome:HGNC:50375 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP4P4; FKBP4P5
FKBP4P7, Official Symbol FKBP4P7provided by HGNC Official Full Name FKBP prolyl isomerase 4 pseudogene 7provided by HGNC Primary source HGNC:HGNC:50376 See related Ensembl:ENSG00000235256 AllianceGenome:HGNC:50376 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FKBP4P3
FKBP4P8, Official Symbol FKBP4P8provided by HGNC Official Full Name FKBP prolyl isomerase 4 pseudogene 8provided by HGNC Primary source HGNC:HGNC:50377 See related Ensembl:ENSG00000276457 AllianceGenome:HGNC:50377 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
FKBP5, Official Symbol FKBP5provided by HGNC Official Full Name FKBP prolyl isomerase 5provided by HGNC Primary source HGNC:HGNC:3721 See related Ensembl:ENSG00000096060 MIM:602623; AllianceGenome:HGNC:3721 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10 Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] Expression Broad expression in fat (RPKM 97.5), lymph node (RPKM 33.3) and 18 other tissues See more Orthologs mouse all