psui3905/ncbi_genes_summary huggingface dataset:
DCAF15, Official Symbol DCAF15provided by HGNC Official Full Name DDB1 and CUL4 associated factor 15provided by HGNC Primary source HGNC:HGNC:25095 See related Ensembl:ENSG00000132017 MIM:620109; AllianceGenome:HGNC:25095 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C19orf72 Summary Enables small molecule binding activity. Involved in protein polyubiquitination and regulation of natural killer cell activation. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 20.9), bone marrow (RPKM 11.3) and 24 other tissues See more Orthologs mouse all
DCAF16, Official Symbol DCAF16provided by HGNC Official Full Name DDB1 and CUL4 associated factor 16provided by HGNC Primary source HGNC:HGNC:25987 See related Ensembl:ENSG00000163257 AllianceGenome:HGNC:25987 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C4orf30 Summary Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 5.2), endometrium (RPKM 5.1) and 25 other tissues See more Orthologs all
DCAF17, Official Symbol DCAF17provided by HGNC Official Full Name DDB1 and CUL4 associated factor 17provided by HGNC Primary source HGNC:HGNC:25784 See related Ensembl:ENSG00000115827 MIM:612515; AllianceGenome:HGNC:25784 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf37; C20orf37 Summary This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Expression Ubiquitous expression in thyroid (RPKM 5.0), testis (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
DCAF4, Official Symbol DCAF4provided by HGNC Official Full Name DDB1 and CUL4 associated factor 4provided by HGNC Primary source HGNC:HGNC:20229 See related Ensembl:ENSG00000119599 MIM:616372; AllianceGenome:HGNC:20229 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WDR21; WDR21A Summary This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009] Expression Ubiquitous expression in thyroid (RPKM 4.7), testis (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
DCAF4L1, Official Symbol DCAF4L1provided by HGNC Official Full Name DDB1 and CUL4 associated factor 4 like 1provided by HGNC Primary source HGNC:HGNC:27723 See related Ensembl:ENSG00000182308 AllianceGenome:HGNC:27723 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WDR21B Orthologs all
DCAF4L2, Official Symbol DCAF4L2provided by HGNC Official Full Name DDB1 and CUL4 associated factor 4 like 2provided by HGNC Primary source HGNC:HGNC:26657 See related Ensembl:ENSG00000176566 MIM:620421; AllianceGenome:HGNC:26657 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WDR21C Orthologs all
DCAF5, Official Symbol DCAF5provided by HGNC Official Full Name DDB1 and CUL4 associated factor 5provided by HGNC Primary source HGNC:HGNC:20224 See related Ensembl:ENSG00000139990 MIM:603812; AllianceGenome:HGNC:20224 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCRG2; BCRP2; WDR22; D14S1461E Summary Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 20.5), thyroid (RPKM 9.2) and 25 other tissues See more Orthologs mouse all
DCAF6, Official Symbol DCAF6provided by HGNC Official Full Name DDB1 and CUL4 associated factor 6provided by HGNC Primary source HGNC:HGNC:30002 See related Ensembl:ENSG00000143164 MIM:610494; AllianceGenome:HGNC:30002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRIP; ARCAP; IQWD1; PC326; MSTP055; 1200006M05Rik Summary The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017] Expression Broad expression in testis (RPKM 48.7), heart (RPKM 45.3) and 24 other tissues See more Orthologs mouse all
DCAF7, Official Symbol DCAF7provided by HGNC Official Full Name DDB1 and CUL4 associated factor 7provided by HGNC Primary source HGNC:HGNC:30915 See related Ensembl:ENSG00000136485 MIM:605973; AllianceGenome:HGNC:30915 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AN11; HAN11; WDR68; SWAN-1 Summary This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in kidney (RPKM 18.2), brain (RPKM 17.9) and 25 other tissues See more Orthologs mouse all
DCAF8, Official Symbol DCAF8provided by HGNC Official Full Name DDB1 and CUL4 associated factor 8provided by HGNC Primary source HGNC:HGNC:24891 See related Ensembl:ENSG00000132716 MIM:615820; AllianceGenome:HGNC:24891 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAN2; H326; WDR42A Summary This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009] Expression Ubiquitous expression in thyroid (RPKM 31.0), brain (RPKM 23.6) and 25 other tissues See more Orthologs mouse all
DCAF8L1, Official Symbol DCAF8L1provided by HGNC Official Full Name DDB1 and CUL4 associated factor 8 like 1provided by HGNC Primary source HGNC:HGNC:31810 See related Ensembl:ENSG00000226372 AllianceGenome:HGNC:31810 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WDR42B Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 1. However, the CDS of this intronless gene remains intact, it is conserved in other primate species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010] Orthologs all
DCAF8L2, Official Symbol DCAF8L2provided by HGNC Official Full Name DDB1 and CUL4 associated factor 8 like 2provided by HGNC Primary source HGNC:HGNC:31811 See related Ensembl:ENSG00000189186 AllianceGenome:HGNC:31811 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WDR42C Summary Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
DCAKD, Official Symbol DCAKDprovided by HGNC Official Full Name dephospho-CoA kinase domain containingprovided by HGNC Primary source HGNC:HGNC:26238 See related Ensembl:ENSG00000172992 AllianceGenome:HGNC:26238 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 10.9), thyroid (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
DCANP1, Official Symbol DCANP1provided by HGNC Official Full Name dendritic cell associated nuclear protein 1provided by HGNC Primary source HGNC:HGNC:24459 See related Ensembl:ENSG00000251380 MIM:609710; AllianceGenome:HGNC:24459 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCNP1; C5orf20 Summary This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008] Orthologs all
DCBLD1, Official Symbol DCBLD1provided by HGNC Official Full Name discoidin, CUB and LCCL domain containing 1provided by HGNC Primary source HGNC:HGNC:21479 See related Ensembl:ENSG00000164465 AllianceGenome:HGNC:21479 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dJ94G16.1 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in gall bladder (RPKM 5.3), placenta (RPKM 4.6) and 25 other tissues See more Orthologs mouse all
DCBLD2, Official Symbol DCBLD2provided by HGNC Official Full Name discoidin, CUB and LCCL domain containing 2provided by HGNC Primary source HGNC:HGNC:24627 See related Ensembl:ENSG00000057019 MIM:608698; AllianceGenome:HGNC:24627 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ESDN; CLCP1 Summary Involved in negative regulation of cell growth and wound healing. Located in cell surface. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 18.8), heart (RPKM 11.1) and 22 other tissues See more Orthologs mouse all
DCC, Official Symbol DCCprovided by HGNC Official Full Name DCC netrin 1 receptorprovided by HGNC Primary source HGNC:HGNC:2701 See related Ensembl:ENSG00000187323 MIM:120470; AllianceGenome:HGNC:2701 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1 Summary This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009] Expression Biased expression in testis (RPKM 2.4), brain (RPKM 1.4) and 2 other tissues See more Orthologs mouse all
DCD, Official Symbol DCDprovided by HGNC Official Full Name dermcidinprovided by HGNC Primary source HGNC:HGNC:14669 See related Ensembl:ENSG00000161634 MIM:606634; AllianceGenome:HGNC:14669 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PIF; AIDD; DSEP; HCAP; DCD-1 Summary This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] Expression Low expression observed in reference dataset See more Orthologs all
DCDC1, Official Symbol DCDC1provided by HGNC Official Full Name doublecortin domain containing 1provided by HGNC Primary source HGNC:HGNC:20625 See related Ensembl:ENSG00000170959 MIM:608062; AllianceGenome:HGNC:20625 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCDC5 Summary This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010] Expression Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.3) and 3 other tissues See more Orthologs mouse all
DCDC2, Official Symbol DCDC2provided by HGNC Official Full Name doublecortin domain containing 2provided by HGNC Primary source HGNC:HGNC:18141 See related Ensembl:ENSG00000146038 MIM:605755; AllianceGenome:HGNC:18141 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NSC; RU2; RU2S; DCDC2A; DFNB66; NPHP19 Summary This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013] Expression Biased expression in kidney (RPKM 12.9), thyroid (RPKM 5.3) and 8 other tissues See more Orthologs mouse all
DCDC2B, Official Symbol DCDC2Bprovided by HGNC Official Full Name doublecortin domain containing 2Bprovided by HGNC Primary source HGNC:HGNC:32576 See related Ensembl:ENSG00000222046 AllianceGenome:HGNC:32576 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010] Expression Broad expression in testis (RPKM 2.4), lung (RPKM 2.3) and 25 other tissues See more Orthologs mouse all
DCDC2C, Official Symbol DCDC2Cprovided by HGNC Official Full Name doublecortin domain containing 2Cprovided by HGNC Primary source HGNC:HGNC:32696 See related Ensembl:ENSG00000214866 AllianceGenome:HGNC:32696 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in intracellular signal transduction. Located in cytoplasm and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
DCHS1, Official Symbol DCHS1provided by HGNC Official Full Name dachsous cadherin-related 1provided by HGNC Primary source HGNC:HGNC:13681 See related Ensembl:ENSG00000166341 MIM:603057; AllianceGenome:HGNC:13681 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIB1; MVP2; CDH19; CDH25; CDHR6; MMVP2; PCDH16; VMLDS1 Summary This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 15.0), placenta (RPKM 6.8) and 22 other tissues See more Orthologs mouse all
DCHS2, Official Symbol DCHS2provided by HGNC Official Full Name dachsous cadherin-related 2provided by HGNC Primary source HGNC:HGNC:23111 See related Ensembl:ENSG00000197410 MIM:612486; AllianceGenome:HGNC:23111 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDHJ; CDH27; CDHR7; PCDHJ; PCDH23 Summary This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass. [provided by RefSeq, May 2017] Expression Broad expression in stomach (RPKM 1.1), testis (RPKM 0.9) and 16 other tissues See more Orthologs mouse all
DCK, Official Symbol DCKprovided by HGNC Official Full Name deoxycytidine kinaseprovided by HGNC Primary source HGNC:HGNC:2704 See related Ensembl:ENSG00000156136 MIM:125450; AllianceGenome:HGNC:2704 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 50.3), appendix (RPKM 23.2) and 22 other tissues See more Orthologs mouse all
DCLK1, Official Symbol DCLK1provided by HGNC Official Full Name doublecortin like kinase 1provided by HGNC Primary source HGNC:HGNC:2700 See related Ensembl:ENSG00000133083 MIM:604742; AllianceGenome:HGNC:2700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL1; DCLK; CLICK1; DCDC3A; DCAMKL1 Summary This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010] Expression Biased expression in brain (RPKM 28.5), fat (RPKM 4.0) and 7 other tissues See more Orthologs mouse all
DCLK2, Official Symbol DCLK2provided by HGNC Official Full Name doublecortin like kinase 2provided by HGNC Primary source HGNC:HGNC:19002 See related Ensembl:ENSG00000170390 MIM:613166; AllianceGenome:HGNC:19002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II Summary This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010] Expression Biased expression in brain (RPKM 21.2), heart (RPKM 3.5) and 9 other tissues See more Orthologs mouse all
DCLK3, Official Symbol DCLK3provided by HGNC Official Full Name doublecortin like kinase 3provided by HGNC Primary source HGNC:HGNC:19005 See related Ensembl:ENSG00000163673 MIM:613167; AllianceGenome:HGNC:19005 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLR; DCK3; DCDC3C; DCAMKL3 Summary Predicted to enable protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to act upstream of or within negative regulation of protein localization to nucleus. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 2.2), brain (RPKM 0.5) and 6 other tissues See more Orthologs mouse all
DCLRE1A, Official Symbol DCLRE1Aprovided by HGNC Official Full Name DNA cross-link repair 1Aprovided by HGNC Primary source HGNC:HGNC:17660 See related Ensembl:ENSG00000198924 MIM:609682; AllianceGenome:HGNC:17660 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSO2; SNM1; SNM1A Summary This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] Expression Ubiquitous expression in thyroid (RPKM 3.4), testis (RPKM 3.3) and 25 other tissues See more Orthologs mouse all
DCLRE1B, Official Symbol DCLRE1Bprovided by HGNC Official Full Name DNA cross-link repair 1Bprovided by HGNC Primary source HGNC:HGNC:17641 See related Ensembl:ENSG00000118655 MIM:609683; AllianceGenome:HGNC:17641 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DKCB8; SNM1B; SNMIB; APOLLO Summary DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in bone marrow (RPKM 3.3), appendix (RPKM 3.2) and 25 other tissues See more Orthologs mouse all
DCLRE1C, Official Symbol DCLRE1Cprovided by HGNC Official Full Name DNA cross-link repair 1Cprovided by HGNC Primary source HGNC:HGNC:17642 See related Ensembl:ENSG00000152457 MIM:605988; AllianceGenome:HGNC:17642 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCIDA; SNM1C; A-SCID; RS-SCID; DCLREC1C Summary This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Ubiquitous expression in lymph node (RPKM 3.7), spleen (RPKM 2.8) and 24 other tissues See more Orthologs mouse all
DCLRE1CP1, Official Symbol DCLRE1CP1provided by HGNC Official Full Name DNA cross-link repair 1C pseudogene 1provided by HGNC Primary source HGNC:HGNC:44877 See related AllianceGenome:HGNC:44877 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
DCN, Official Symbol DCNprovided by HGNC Official Full Name decorinprovided by HGNC Primary source HGNC:HGNC:2705 See related Ensembl:ENSG00000011465 MIM:125255; AllianceGenome:HGNC:2705 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B Summary This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015] Expression Broad expression in ovary (RPKM 562.9), gall bladder (RPKM 411.1) and 18 other tissues See more Orthologs mouse all
DCP1A, Official Symbol DCP1Aprovided by HGNC Official Full Name decapping mRNA 1Aprovided by HGNC Primary source HGNC:HGNC:18714 See related Ensembl:ENSG00000272886 MIM:607010; AllianceGenome:HGNC:18714 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SMIF; SMAD4IP1; HSA275986; Nbla00360 Summary Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in bone marrow (RPKM 10.4), ovary (RPKM 7.6) and 25 other tissues See more Orthologs mouse all
DCP1B, Official Symbol DCP1Bprovided by HGNC Official Full Name decapping mRNA 1Bprovided by HGNC Primary source HGNC:HGNC:24451 See related Ensembl:ENSG00000151065 MIM:609843; AllianceGenome:HGNC:24451 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCP1 Summary This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Broad expression in testis (RPKM 7.9), endometrium (RPKM 5.4) and 25 other tissues See more Orthologs mouse all
DCP2, Official Symbol DCP2provided by HGNC Official Full Name decapping mRNA 2provided by HGNC Primary source HGNC:HGNC:24452 See related Ensembl:ENSG00000172795 MIM:609844; AllianceGenome:HGNC:24452 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NUDT20 Summary The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] Expression Ubiquitous expression in lymph node (RPKM 7.7), placenta (RPKM 6.8) and 24 other tissues See more Orthologs mouse all
DCPS, Official Symbol DCPSprovided by HGNC Official Full Name decapping enzyme, scavengerprovided by HGNC Primary source HGNC:HGNC:29812 See related Ensembl:ENSG00000110063 MIM:610534; AllianceGenome:HGNC:29812 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015 Summary This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5&#8242; mRNA cap structure, which appear in the 3&#8242; &#8594; 5&#8242; mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017] Expression Ubiquitous expression in lymph node (RPKM 6.1), gall bladder (RPKM 5.3) and 25 other tissues See more Orthologs mouse all
DCST1, Official Symbol DCST1provided by HGNC Official Full Name DC-STAMP domain containing 1provided by HGNC Primary source HGNC:HGNC:26539 See related Ensembl:ENSG00000163357 MIM:619860; AllianceGenome:HGNC:26539 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SNKY; SPE49 Summary This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Biased expression in testis (RPKM 2.9), skin (RPKM 1.8) and 8 other tissues See more Orthologs mouse all
DCST1-AS1, Official Symbol DCST1-AS1provided by HGNC Official Full Name DCST1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41147 See related AllianceGenome:HGNC:41147 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in skin (RPKM 2.7), colon (RPKM 1.3) and 23 other tissues See more
DCST2, Official Symbol DCST2provided by HGNC Official Full Name DC-STAMP domain containing 2provided by HGNC Primary source HGNC:HGNC:26562 See related Ensembl:ENSG00000163354 MIM:619861; AllianceGenome:HGNC:26562 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPE42 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 28.4), duodenum (RPKM 18.1) and 16 other tissues See more Orthologs mouse all
DCSTAMP, Official Symbol DCSTAMPprovided by HGNC Official Full Name dendrocyte expressed seven transmembrane proteinprovided by HGNC Primary source HGNC:HGNC:18549 See related Ensembl:ENSG00000164935 MIM:605933; AllianceGenome:HGNC:18549 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FIND; TM7SF4; hDC-STAMP Summary This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] Expression Biased expression in lung (RPKM 1.3), liver (RPKM 0.2) and 4 other tissues See more Orthologs mouse all
DCT, Official Symbol DCTprovided by HGNC Official Full Name dopachrome tautomeraseprovided by HGNC Primary source HGNC:HGNC:2709 See related Ensembl:ENSG00000080166 MIM:191275; AllianceGenome:HGNC:2709 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OCA8; TRP-2; TYRP2 Summary Predicted to enable dopachrome isomerase activity. Involved in response to blue light. Located in intracellular membrane-bounded organelle and plasma membrane. Implicated in oculocutaneous albinism. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward skin (RPKM 44.8) See more Orthologs mouse all
DCTD, Official Symbol DCTDprovided by HGNC Official Full Name dCMP deaminaseprovided by HGNC Primary source HGNC:HGNC:2710 See related Ensembl:ENSG00000129187 MIM:607638; AllianceGenome:HGNC:2710 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 37.0), adrenal (RPKM 19.8) and 25 other tissues See more Orthologs mouse all
DCTN1, Official Symbol DCTN1provided by HGNC Official Full Name dynactin subunit 1provided by HGNC Primary source HGNC:HGNC:2711 See related Ensembl:ENSG00000204843 MIM:601143; AllianceGenome:HGNC:2711 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P135; DP-150; DAP-150 Summary This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in brain (RPKM 71.1), testis (RPKM 43.6) and 25 other tissues See more Orthologs mouse all
DCTN1-AS1, Official Symbol DCTN1-AS1provided by HGNC Official Full Name DCTN1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:44151 See related Ensembl:ENSG00000237737 AllianceGenome:HGNC:44151 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in brain (RPKM 1.6), fat (RPKM 0.6) and 11 other tissues See more
DCTN2, Official Symbol DCTN2provided by HGNC Official Full Name dynactin subunit 2provided by HGNC Primary source HGNC:HGNC:2712 See related Ensembl:ENSG00000175203 MIM:607376; AllianceGenome:HGNC:2712 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RBP50; DCTN50; HEL-S-77; DYNAMITIN Summary This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012] Expression Ubiquitous expression in brain (RPKM 42.2), esophagus (RPKM 36.9) and 25 other tissues See more Orthologs mouse all
DCTN3, Official Symbol DCTN3provided by HGNC Official Full Name dynactin subunit 3provided by HGNC Primary source HGNC:HGNC:2713 See related Ensembl:ENSG00000137100 MIM:607387; AllianceGenome:HGNC:2713 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCTN22; DCTN-22 Summary This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in brain (RPKM 30.6), bone marrow (RPKM 26.1) and 25 other tissues See more Orthologs mouse all
DCTN4, Official Symbol DCTN4provided by HGNC Official Full Name dynactin subunit 4provided by HGNC Primary source HGNC:HGNC:15518 See related Ensembl:ENSG00000132912 MIM:614758; AllianceGenome:HGNC:15518 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P62; DYN4 Summary Enables protein N-terminus binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 24.6), bone marrow (RPKM 19.3) and 25 other tissues See more Orthologs mouse all
DCTN5, Official Symbol DCTN5provided by HGNC Official Full Name dynactin subunit 5provided by HGNC Primary source HGNC:HGNC:24594 See related Ensembl:ENSG00000166847 MIM:612962; AllianceGenome:HGNC:24594 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Expression Ubiquitous expression in brain (RPKM 13.0), testis (RPKM 7.5) and 25 other tissues See more Orthologs mouse all
DCTN6, Official Symbol DCTN6provided by HGNC Official Full Name dynactin subunit 6provided by HGNC Primary source HGNC:HGNC:16964 See related Ensembl:ENSG00000104671 MIM:612963; AllianceGenome:HGNC:16964 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WS3; p27; WS-3 Summary The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 33.5), fat (RPKM 26.8) and 25 other tissues See more Orthologs mouse all