psui3905/ncbi_genes_summary huggingface dataset:
PSMB10, Official Symbol PSMB10provided by HGNC Official Full Name proteasome 20S subunit beta 10provided by HGNC Primary source HGNC:HGNC:9538 See related Ensembl:ENSG00000205220 MIM:176847; AllianceGenome:HGNC:9538 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LMP10; MECL1; PRAAS5; beta2i Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 53.2), lymph node (RPKM 48.6) and 25 other tissues See more Orthologs mouse all
PSMB11, Official Symbol PSMB11provided by HGNC Official Full Name proteasome subunit beta 11provided by HGNC Primary source HGNC:HGNC:31963 See related Ensembl:ENSG00000222028 MIM:611137; AllianceGenome:HGNC:31963 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BETA5T Summary Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008] Orthologs mouse all
PSMB2, Official Symbol PSMB2provided by HGNC Official Full Name proteasome 20S subunit beta 2provided by HGNC Primary source HGNC:HGNC:9539 See related Ensembl:ENSG00000126067 MIM:602175; AllianceGenome:HGNC:9539 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC7-I Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] Expression Ubiquitous expression in placenta (RPKM 11.8), lymph node (RPKM 10.8) and 25 other tissues See more Orthologs mouse all
PSMB3, Official Symbol PSMB3provided by HGNC Official Full Name proteasome 20S subunit beta 3provided by HGNC Primary source HGNC:HGNC:9540 See related Ensembl:ENSG00000277791 MIM:602176; AllianceGenome:HGNC:9540 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HC10-II Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013] Expression Ubiquitous expression in appendix (RPKM 52.0), lymph node (RPKM 51.4) and 25 other tissues See more Orthologs mouse all
PSMB3P1, Official Symbol PSMB3P1provided by HGNC Official Full Name proteasome subunit beta 3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:20633 See related Ensembl:ENSG00000258907 AllianceGenome:HGNC:20633 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSMB3P
PSMB3P2, Official Symbol PSMB3P2provided by HGNC Official Full Name proteasome subunit beta 3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:30150 See related Ensembl:ENSG00000235444 AllianceGenome:HGNC:30150 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMB4, Official Symbol PSMB4provided by HGNC Official Full Name proteasome 20S subunit beta 4provided by HGNC Primary source HGNC:HGNC:9541 See related Ensembl:ENSG00000159377 MIM:602177; AllianceGenome:HGNC:9541 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HN3; HsN3; PRAAS3; PROS26; PROS-26 Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 102.8), lymph node (RPKM 94.8) and 25 other tissues See more Orthologs mouse all
PSMB5, Official Symbol PSMB5provided by HGNC Official Full Name proteasome 20S subunit beta 5provided by HGNC Primary source HGNC:HGNC:9542 See related Ensembl:ENSG00000100804 MIM:600306; AllianceGenome:HGNC:9542 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MB1; LMPX Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] Expression Ubiquitous expression in brain (RPKM 31.9), placenta (RPKM 30.5) and 25 other tissues See more Orthologs mouse all
PSMB6, Official Symbol PSMB6provided by HGNC Official Full Name proteasome 20S subunit beta 6provided by HGNC Primary source HGNC:HGNC:9543 See related Ensembl:ENSG00000142507 MIM:600307; AllianceGenome:HGNC:9543 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LMPY; DELTA Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in placenta (RPKM 53.0), heart (RPKM 51.7) and 25 other tissues See more Orthologs mouse all
PSMB7, Official Symbol PSMB7provided by HGNC Official Full Name proteasome 20S subunit beta 7provided by HGNC Primary source HGNC:HGNC:9544 See related Ensembl:ENSG00000136930 MIM:604030; AllianceGenome:HGNC:9544 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in testis (RPKM 70.4), adrenal (RPKM 65.0) and 25 other tissues See more Orthologs mouse all
PSMB8, Official Symbol PSMB8provided by HGNC Official Full Name proteasome 20S subunit beta 8provided by HGNC Primary source HGNC:HGNC:9545 See related Ensembl:ENSG00000204264 MIM:177046; AllianceGenome:HGNC:9545 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as JMP; ALDD; LMP7; NKJO; D6S216; PRAAS1; PSMB5i; RING10; D6S216E Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 49.9), spleen (RPKM 45.7) and 24 other tissues See more Orthologs mouse all
PSMB8-AS1, Official Symbol PSMB8-AS1provided by HGNC Official Full Name PSMB8 antisense RNA 1 (head to head)provided by HGNC Primary source HGNC:HGNC:39758 See related Ensembl:ENSG00000204261 AllianceGenome:HGNC:39758 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAPSAR1; TAP1-AS1 Expression Broad expression in spleen (RPKM 54.1), lymph node (RPKM 51.8) and 24 other tissues See more
PSMB9, Official Symbol PSMB9provided by HGNC Official Full Name proteasome 20S subunit beta 9provided by HGNC Primary source HGNC:HGNC:9546 See related Ensembl:ENSG00000240065 MIM:177045; AllianceGenome:HGNC:9546 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LMP2; PRAAS3; PSMB6i; RING12; beta1i Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010] Expression Broad expression in spleen (RPKM 72.3), lymph node (RPKM 60.9) and 24 other tissues See more Orthologs mouse all
PSMC1, Official Symbol PSMC1provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1provided by HGNC Primary source HGNC:HGNC:9547 See related Ensembl:ENSG00000100764 MIM:602706; AllianceGenome:HGNC:9547 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S4; p56; RPT2; P26S4; NEDGTH Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 27.5), fat (RPKM 23.0) and 25 other tissues See more Orthologs mouse all
PSMC1P1, Official Symbol PSMC1P1provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:30147 See related Ensembl:ENSG00000241506 AllianceGenome:HGNC:30147 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSMC1P; bcm3415
PSMC1P10, Official Symbol PSMC1P10provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 10provided by HGNC Primary source HGNC:HGNC:39785 See related Ensembl:ENSG00000236348 AllianceGenome:HGNC:39785 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P11, Official Symbol PSMC1P11provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 11provided by HGNC Primary source HGNC:HGNC:39786 See related Ensembl:ENSG00000217385 AllianceGenome:HGNC:39786 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P12, Official Symbol PSMC1P12provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 12provided by HGNC Primary source HGNC:HGNC:39787 See related Ensembl:ENSG00000226126 AllianceGenome:HGNC:39787 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P2, Official Symbol PSMC1P2provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:39777 See related Ensembl:ENSG00000213781 AllianceGenome:HGNC:39777 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P3, Official Symbol PSMC1P3provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:39778 See related Ensembl:ENSG00000231244 AllianceGenome:HGNC:39778 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P4, Official Symbol PSMC1P4provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:39779 See related Ensembl:ENSG00000248781 AllianceGenome:HGNC:39779 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P5, Official Symbol PSMC1P5provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:39780 See related Ensembl:ENSG00000250273 AllianceGenome:HGNC:39780 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P6, Official Symbol PSMC1P6provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 6provided by HGNC Primary source HGNC:HGNC:39781 See related Ensembl:ENSG00000240255 AllianceGenome:HGNC:39781 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P7, Official Symbol PSMC1P7provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 7provided by HGNC Primary source HGNC:HGNC:39782 See related Ensembl:ENSG00000243838 AllianceGenome:HGNC:39782 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P8, Official Symbol PSMC1P8provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 8provided by HGNC Primary source HGNC:HGNC:39783 See related Ensembl:ENSG00000256896 AllianceGenome:HGNC:39783 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC1P9, Official Symbol PSMC1P9provided by HGNC Official Full Name proteasome 26S subunit, ATPase 1 pseudogene 9provided by HGNC Primary source HGNC:HGNC:39784 See related Ensembl:ENSG00000255993 AllianceGenome:HGNC:39784 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC2, Official Symbol PSMC2provided by HGNC Official Full Name proteasome 26S subunit, ATPase 2provided by HGNC Primary source HGNC:HGNC:9548 See related Ensembl:ENSG00000161057 MIM:154365; AllianceGenome:HGNC:9548 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S7; MSS1; RPT1; Nbla10058 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011] Expression Ubiquitous expression in adrenal (RPKM 22.7), kidney (RPKM 22.5) and 25 other tissues See more Orthologs mouse all
PSMC2P1, Official Symbol PSMC2P1provided by HGNC Official Full Name PSMC2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:54571 See related Ensembl:ENSG00000240854 AllianceGenome:HGNC:54571 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC2P2, Official Symbol PSMC2P2provided by HGNC Official Full Name PSMC2 pseudogene 2provided by HGNC Primary source HGNC:HGNC:54573 See related Ensembl:ENSG00000253137 AllianceGenome:HGNC:54573 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMC3, Official Symbol PSMC3provided by HGNC Official Full Name proteasome 26S subunit, ATPase 3provided by HGNC Primary source HGNC:HGNC:9549 See related Ensembl:ENSG00000165916 MIM:186852; AllianceGenome:HGNC:9549 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RPT5; TBP1; DCIDP Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 35.4), brain (RPKM 35.2) and 25 other tissues See more Orthologs mouse all
PSMC3IP, Official Symbol PSMC3IPprovided by HGNC Official Full Name PSMC3 interacting proteinprovided by HGNC Primary source HGNC:HGNC:17928 See related Ensembl:ENSG00000131470 MIM:608665; AllianceGenome:HGNC:17928 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HOP2; ODG3; GT198; TBPIP; HUMGT198A Summary This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011] Expression Ubiquitous expression in duodenum (RPKM 12.8), small intestine (RPKM 12.7) and 25 other tissues See more Orthologs mouse all
PSMC4, Official Symbol PSMC4provided by HGNC Official Full Name proteasome 26S subunit, ATPase 4provided by HGNC Primary source HGNC:HGNC:9551 See related Ensembl:ENSG00000013275 MIM:602707; AllianceGenome:HGNC:9551 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S6; RPT3; TBP7; TBP-7; MIP224 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.9) and 25 other tissues See more Orthologs mouse all
PSMC5, Official Symbol PSMC5provided by HGNC Official Full Name proteasome 26S subunit, ATPase 5provided by HGNC Primary source HGNC:HGNC:9552 See related Ensembl:ENSG00000087191 MIM:601681; AllianceGenome:HGNC:9552 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S8; p45; RPT6; SUG1; SUG-1; TBP10; TRIP1; p45/SUG Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Expression Ubiquitous expression in kidney (RPKM 58.1), brain (RPKM 54.9) and 25 other tissues See more Orthologs mouse all
PSMC6, Official Symbol PSMC6provided by HGNC Official Full Name proteasome 26S subunit, ATPase 6provided by HGNC Primary source HGNC:HGNC:9553 See related Ensembl:ENSG00000100519 MIM:602708; AllianceGenome:HGNC:9553 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p42; RPT5; SUG2 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in esophagus (RPKM 15.2), brain (RPKM 15.0) and 25 other tissues See more Orthologs mouse all
PSMD1, Official Symbol PSMD1provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase 1provided by HGNC Primary source HGNC:HGNC:9554 See related Ensembl:ENSG00000173692 MIM:617842; AllianceGenome:HGNC:9554 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S1; P112; Rpn2 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. There is evidence that this proteasome and its subunits interact with viral proteins, including those of coronaviruses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in brain (RPKM 24.7), appendix (RPKM 17.2) and 25 other tissues See more Orthologs mouse all
PSMD10, Official Symbol PSMD10provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase 10provided by HGNC Primary source HGNC:HGNC:9555 See related Ensembl:ENSG00000101843 MIM:300880; AllianceGenome:HGNC:9555 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p28; p28(GANK); dJ889N15.2 Summary This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011] Expression Ubiquitous expression in brain (RPKM 23.6), thyroid (RPKM 20.0) and 25 other tissues See more Orthologs mouse all
PSMD10P2, Official Symbol PSMD10P2provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase, 10 pseudogene 2provided by HGNC Primary source HGNC:HGNC:30151 See related AllianceGenome:HGNC:30151 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMD10P3, Official Symbol PSMD10P3provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase, 10 pseudogene 3provided by HGNC Primary source HGNC:HGNC:30152 See related Ensembl:ENSG00000232041 AllianceGenome:HGNC:30152 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PSMD11, Official Symbol PSMD11provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase 11provided by HGNC Primary source HGNC:HGNC:9556 See related Ensembl:ENSG00000108671 MIM:604449; AllianceGenome:HGNC:9556 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S9; Rpn6; p44.5 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in testis (RPKM 16.9), placenta (RPKM 15.8) and 25 other tissues See more Orthologs mouse all
PSMD12, Official Symbol PSMD12provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase 12provided by HGNC Primary source HGNC:HGNC:9557 See related Ensembl:ENSG00000197170 MIM:604450; AllianceGenome:HGNC:9557 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p55; Rpn5; STISS Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in testis (RPKM 12.2), bone marrow (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
PSMD12P1, Official Symbol PSMD12P1provided by HGNC Official Full Name PSMD12 pseudogene 1provided by HGNC Primary source HGNC:HGNC:30153 See related Ensembl:ENSG00000240135 AllianceGenome:HGNC:30153 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSMD12P
PSMD13, Official Symbol PSMD13provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase 13provided by HGNC Primary source HGNC:HGNC:9558 See related Ensembl:ENSG00000185627 MIM:603481; AllianceGenome:HGNC:9558 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S11; Rpn9; p40.5; HSPC027 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in appendix (RPKM 33.3), lymph node (RPKM 32.2) and 25 other tissues See more Orthologs mouse all
PSMD14, Official Symbol PSMD14provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase 14provided by HGNC Primary source HGNC:HGNC:16889 See related Ensembl:ENSG00000115233 MIM:607173; AllianceGenome:HGNC:16889 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAD1; POH1; RPN11 Summary This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012] Expression Ubiquitous expression in brain (RPKM 24.9), testis (RPKM 22.1) and 25 other tissues See more Orthologs mouse all
PSMD2, Official Symbol PSMD2provided by HGNC Official Full Name proteasome 26S subunit ubiquitin receptor, non-ATPase 2provided by HGNC Primary source HGNC:HGNC:9559 See related Ensembl:ENSG00000175166 MIM:606223; AllianceGenome:HGNC:9559 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S2; P97; RPN1; TRAP2 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in testis (RPKM 64.5), brain (RPKM 40.8) and 25 other tissues See more Orthologs mouse all
PSMD3, Official Symbol PSMD3provided by HGNC Official Full Name proteasome 26S subunit, non-ATPase 3provided by HGNC Primary source HGNC:HGNC:9560 See related Ensembl:ENSG00000108344 MIM:617676; AllianceGenome:HGNC:9560 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S3; P58; RPN3; TSTA2 Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in colon (RPKM 31.7), brain (RPKM 31.3) and 25 other tissues See more Orthologs mouse all