psui3905/ncbi_genes_summary huggingface dataset:
PRPF19P1, Official Symbol PRPF19P1provided by HGNC Official Full Name PRPF19 pseudogene 1provided by HGNC Primary source HGNC:HGNC:23182 See related Ensembl:ENSG00000264685 AllianceGenome:HGNC:23182 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRP19P; HsT1682; PRPF19P
PRPF3, Official Symbol PRPF3provided by HGNC Official Full Name pre-mRNA processing factor 3provided by HGNC Primary source HGNC:HGNC:17348 See related Ensembl:ENSG00000117360 MIM:607301; AllianceGenome:HGNC:17348 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRP3; RP18; HPRP3; Prp3p; HPRP3P; SNRNP90 Summary The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 15.4), endometrium (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
PRPF31, Official Symbol PRPF31provided by HGNC Official Full Name pre-mRNA processing factor 31provided by HGNC Primary source HGNC:HGNC:15446 See related Ensembl:ENSG00000105618 MIM:606419; AllianceGenome:HGNC:15446 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP11; PRP31; SNRNP61; NY-BR-99 Summary This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009] Expression Ubiquitous expression in spleen (RPKM 14.1), endometrium (RPKM 14.0) and 25 other tissues See more Orthologs mouse all
PRPF38A, Official Symbol PRPF38Aprovided by HGNC Official Full Name pre-mRNA processing factor 38Aprovided by HGNC Primary source HGNC:HGNC:25930 See related Ensembl:ENSG00000134748 MIM:617031; AllianceGenome:HGNC:25930 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Prp38; PRP38A Summary Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 12.2), ovary (RPKM 11.7) and 25 other tissues See more Orthologs mouse all
PRPF38AP2, Official Symbol PRPF38AP2provided by HGNC Official Full Name PRP38 domain containing A pseudogene 2provided by HGNC Primary source HGNC:HGNC:44693 See related Ensembl:ENSG00000236582 AllianceGenome:HGNC:44693 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRPF38B, Official Symbol PRPF38Bprovided by HGNC Official Full Name pre-mRNA processing factor 38Bprovided by HGNC Primary source HGNC:HGNC:25512 See related Ensembl:ENSG00000134186 AllianceGenome:HGNC:25512 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NET1 Summary Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 13.4), bone marrow (RPKM 12.6) and 25 other tissues See more Orthologs mouse all
PRPF39, Official Symbol PRPF39provided by HGNC Official Full Name pre-mRNA processing factor 39provided by HGNC Primary source HGNC:HGNC:20314 See related Ensembl:ENSG00000185246 MIM:614907; AllianceGenome:HGNC:20314 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP; U2-type prespliceosome; and commitment complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 15.3), prostate (RPKM 14.2) and 25 other tissues See more Orthologs mouse all
PRPF4, Official Symbol PRPF4provided by HGNC Official Full Name pre-mRNA processing factor 4provided by HGNC Primary source HGNC:HGNC:17349 See related Ensembl:ENSG00000136875 MIM:607795; AllianceGenome:HGNC:17349 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRP4; RP70; HPRP4; Prp4p; HPRP4P; SNRNP60 Summary The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] Expression Ubiquitous expression in appendix (RPKM 8.9), kidney (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
PRPF40A, Official Symbol PRPF40Aprovided by HGNC Official Full Name pre-mRNA processing factor 40 homolog Aprovided by HGNC Primary source HGNC:HGNC:16463 See related Ensembl:ENSG00000196504 MIM:612941; AllianceGenome:HGNC:16463 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYPA; FBP11; FLAF1; FNBP3; HIP10; Prp40; FBP-11; HIP-10; NY-REN-6 Summary Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in bone marrow (RPKM 15.6), testis (RPKM 13.4) and 25 other tissues See more Orthologs mouse all
PRPF40B, Official Symbol PRPF40Bprovided by HGNC Official Full Name pre-mRNA processing factor 40 homolog Bprovided by HGNC Primary source HGNC:HGNC:25031 See related Ensembl:ENSG00000110844 AllianceGenome:HGNC:25031 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYPC Summary This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014] Expression Broad expression in testis (RPKM 13.2), thyroid (RPKM 7.6) and 23 other tissues See more Orthologs mouse all
PRPF4B, Official Symbol PRPF4Bprovided by HGNC Official Full Name pre-mRNA processing factor 4Bprovided by HGNC Primary source HGNC:HGNC:17346 See related Ensembl:ENSG00000112739 MIM:602338; AllianceGenome:HGNC:17346 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PR4H; PRP4; PRP4H; PRP4K; Prp4B; dJ1013A10.1 Summary Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.5) and 25 other tissues See more Orthologs mouse all
PRPF6, Official Symbol PRPF6provided by HGNC Official Full Name pre-mRNA processing factor 6provided by HGNC Primary source HGNC:HGNC:15860 See related Ensembl:ENSG00000101161 MIM:613979; AllianceGenome:HGNC:15860 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TOM; ANT1; Prp6; RP60; ANT-1; hPrp6; U5-102K; C20orf14; SNRNP102 Summary The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 30.6), ovary (RPKM 27.5) and 25 other tissues See more Orthologs mouse all
PRPF8, Official Symbol PRPF8provided by HGNC Official Full Name pre-mRNA processing factor 8provided by HGNC Primary source HGNC:HGNC:17340 See related Ensembl:ENSG00000174231 MIM:607300; AllianceGenome:HGNC:17340 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRP8; RP13; HPRP8; PRPC8; SNRNP220 Summary Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 48.3), testis (RPKM 47.0) and 25 other tissues See more Orthologs mouse all
PRPH, Official Symbol PRPHprovided by HGNC Official Full Name peripherinprovided by HGNC Primary source HGNC:HGNC:9461 See related Ensembl:ENSG00000135406 MIM:170710; AllianceGenome:HGNC:9461 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEF4; PRPH1 Summary This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008] Annotation information Note: PRPH (Gene ID: 5630) and PRPH2 (Gene ID: 5961) share the PRPH symbol/alias in common. PRPH is sometimes used as an alternative name for peripherin 2 (PRPH2), which can be confused with the official symbol for peripherin (PRPH). [05 Jul 2018] Expression Biased expression in testis (RPKM 11.3), adrenal (RPKM 6.4) and 6 other tissues See more Orthologs mouse all
PRPH2, Official Symbol PRPH2provided by HGNC Official Full Name peripherin 2provided by HGNC Primary source HGNC:HGNC:9942 See related Ensembl:ENSG00000112619 MIM:179605; AllianceGenome:HGNC:9942 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DS; RDS; RP7; rd2; AVMD; PRPH; AOFMD; CACD2; MDBS1; TSPAN22 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic. [provided by RefSeq, Jul 2008] Annotation information Note: PRPH2 (Gene ID: 5961) and PRPH (Gene ID: 5630) loci share the PRPH symbol/alias in common. [08 Feb 2019] Expression Broad expression in brain (RPKM 1.8), thyroid (RPKM 1.7) and 21 other tissues See more Orthologs mouse all
PRPS1, Official Symbol PRPS1provided by HGNC Official Full Name phosphoribosyl pyrophosphate synthetase 1provided by HGNC Primary source HGNC:HGNC:9462 See related Ensembl:ENSG00000147224 MIM:311850; AllianceGenome:HGNC:9462 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARTS; DFN2; PRSI; CMTX5; DFNX1; PRS-I; PPRibP Summary This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in thyroid (RPKM 27.0), brain (RPKM 23.0) and 25 other tissues See more Orthologs mouse all
PRPS1L1, Official Symbol PRPS1L1provided by HGNC Official Full Name phosphoribosyl pyrophosphate synthetase 1 like 1provided by HGNC Primary source HGNC:HGNC:9463 See related Ensembl:ENSG00000229937 MIM:611566; AllianceGenome:HGNC:9463 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRPS1; PRPS3; PRPSL; PRS-III Summary This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq, Jul 2008] Orthologs mouse all
PRPS1P1, Official Symbol PRPS1P1provided by HGNC Official Full Name phosphoribosyl pyrophosphate synthetase 1 pseudogene 1provided by HGNC Primary source HGNC:HGNC:39427 See related Ensembl:ENSG00000226847 AllianceGenome:HGNC:39427 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRPS2, Official Symbol PRPS2provided by HGNC Official Full Name phosphoribosyl pyrophosphate synthetase 2provided by HGNC Primary source HGNC:HGNC:9465 See related Ensembl:ENSG00000101911 MIM:311860; AllianceGenome:HGNC:9465 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRSII Summary This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Expression Broad expression in testis (RPKM 94.5), adrenal (RPKM 26.5) and 22 other tissues See more Orthologs mouse all
PRPSAP1, Official Symbol PRPSAP1provided by HGNC Official Full Name phosphoribosyl pyrophosphate synthetase associated protein 1provided by HGNC Primary source HGNC:HGNC:9466 See related Ensembl:ENSG00000161542 MIM:601249; AllianceGenome:HGNC:9466 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAP39 Summary Enables identical protein binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 21.2), testis (RPKM 17.1) and 25 other tissues See more Orthologs mouse all
PRPSAP2, Official Symbol PRPSAP2provided by HGNC Official Full Name phosphoribosyl pyrophosphate synthetase associated protein 2provided by HGNC Primary source HGNC:HGNC:9467 See related Ensembl:ENSG00000141127 MIM:603762; AllianceGenome:HGNC:9467 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAP41 Summary This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in lymph node (RPKM 12.0), testis (RPKM 9.5) and 25 other tissues See more Orthologs mouse all
PRR11, Official Symbol PRR11provided by HGNC Official Full Name proline rich 11provided by HGNC Primary source HGNC:HGNC:25619 See related Ensembl:ENSG00000068489 MIM:615920; AllianceGenome:HGNC:25619 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Involved in regulation of cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in bone marrow (RPKM 3.3), lymph node (RPKM 2.7) and 20 other tissues See more Orthologs mouse all
PRR12, Official Symbol PRR12provided by HGNC Official Full Name proline rich 12provided by HGNC Primary source HGNC:HGNC:29217 See related Ensembl:ENSG00000126464 MIM:616633; AllianceGenome:HGNC:29217 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NOC; KIAA1205 Summary This gene encodes a proline-rich protein that contains two A-T hook DNA binding domains. A chromosomal translocation and gene fusion between this gene and zinc finger, MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient. Enriched expression of this gene in embryonic mouse brain suggests that this gene may play a role in nervous system development. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in spleen (RPKM 6.1), fat (RPKM 4.6) and 25 other tissues See more Orthologs mouse all
PRR13, Official Symbol PRR13provided by HGNC Official Full Name proline rich 13provided by HGNC Primary source HGNC:HGNC:24528 See related Ensembl:ENSG00000205352 MIM:610459; AllianceGenome:HGNC:24528 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TXR1 Summary Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in small intestine (RPKM 163.5), duodenum (RPKM 160.5) and 24 other tissues See more Orthologs mouse all
PRR13P1, Official Symbol PRR13P1provided by HGNC Official Full Name proline rich 13 pseudogene 1provided by HGNC Primary source HGNC:HGNC:50614 See related AllianceGenome:HGNC:50614 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PRR14, Official Symbol PRR14provided by HGNC Official Full Name proline rich 14provided by HGNC Primary source HGNC:HGNC:28458 See related Ensembl:ENSG00000156858 MIM:617423; AllianceGenome:HGNC:28458 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in spleen (RPKM 13.5), bone marrow (RPKM 12.9) and 25 other tissues See more Orthologs mouse all
PRR14L, Official Symbol PRR14Lprovided by HGNC Official Full Name proline rich 14 likeprovided by HGNC Primary source HGNC:HGNC:28738 See related Ensembl:ENSG00000183530 AllianceGenome:HGNC:28738 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C22orf30 Expression Ubiquitous expression in testis (RPKM 3.6), colon (RPKM 3.5) and 25 other tissues See more Orthologs mouse all
PRR15, Official Symbol PRR15provided by HGNC Official Full Name proline rich 15provided by HGNC Primary source HGNC:HGNC:22310 See related Ensembl:ENSG00000176532 MIM:618344; AllianceGenome:HGNC:22310 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in colon (RPKM 29.0), small intestine (RPKM 15.6) and 6 other tissues See more Orthologs mouse all
PRR15L, Official Symbol PRR15Lprovided by HGNC Official Full Name proline rich 15 likeprovided by HGNC Primary source HGNC:HGNC:28149 See related Ensembl:ENSG00000167183 AllianceGenome:HGNC:28149 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ATAD4 Expression Biased expression in duodenum (RPKM 78.9), small intestine (RPKM 58.5) and 11 other tissues See more Orthologs mouse all
PRR16, Official Symbol PRR16provided by HGNC Official Full Name proline rich 16provided by HGNC Primary source HGNC:HGNC:29654 See related Ensembl:ENSG00000184838 MIM:615931; AllianceGenome:HGNC:29654 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DSC54; LARGEN Summary Involved in positive regulation of cell size and positive regulation of translation. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in endometrium (RPKM 1.3), urinary bladder (RPKM 0.9) and 21 other tissues See more Orthologs mouse all
PRR18, Official Symbol PRR18provided by HGNC Official Full Name proline rich 18provided by HGNC Primary source HGNC:HGNC:28574 See related Ensembl:ENSG00000176381 AllianceGenome:HGNC:28574 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs mouse all
PRR19, Official Symbol PRR19provided by HGNC Official Full Name proline rich 19provided by HGNC Primary source HGNC:HGNC:33728 See related Ensembl:ENSG00000188368 AllianceGenome:HGNC:33728 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 6.5), brain (RPKM 1.5) and 20 other tissues See more Orthologs mouse all
PRR20A, Official Symbol PRR20Aprovided by HGNC Official Full Name proline rich 20Aprovided by HGNC Primary source HGNC:HGNC:24754 See related Ensembl:ENSG00000204919 AllianceGenome:HGNC:24754 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR20; PRR20B; PRR20C; PRR20D; PRR20E Summary This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008] Annotation information Note: This gene is one of five identical loci in a cluster on chromosome 13q21.1. Similar gene clusters are suggested in rhesus, mouse, rabbit, dog, cow, platypus, and armadillo genomic sequences. [22 Jul 2008] Expression Low expression observed in reference dataset See more
PRR20B, Official Symbol PRR20Bprovided by HGNC Official Full Name proline rich 20Bprovided by HGNC Primary source HGNC:HGNC:37220 See related Ensembl:ENSG00000204918 AllianceGenome:HGNC:37220 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR20; PRR20A; PRR20C; PRR20D; PRR20E Summary This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008] Annotation information Note: This gene is one of five identical loci in a cluster on chromosome 13q21.1. Similar gene clusters are suggested in rhesus, mouse, rabbit, dog, cow, platypus, and armadillo genomic sequences. [25 Jul 2008] Expression Low expression observed in reference dataset See more
PRR20C, Official Symbol PRR20Cprovided by HGNC Official Full Name proline rich 20Cprovided by HGNC Primary source HGNC:HGNC:37221 See related Ensembl:ENSG00000229665 AllianceGenome:HGNC:37221 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR20; PRR20A; PRR20B; PRR20D; PRR20E Summary This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008] Annotation information Note: This gene is one of five identical loci in a cluster on chromosome 13q21.1. Similar gene clusters are suggested in rhesus, mouse, rabbit, dog, cow, platypus, and armadillo genomic sequences. [25 Jul 2008] Expression Low expression observed in reference dataset See more
PRR20D, Official Symbol PRR20Dprovided by HGNC Official Full Name proline rich 20Dprovided by HGNC Primary source HGNC:HGNC:37222 See related Ensembl:ENSG00000227151 AllianceGenome:HGNC:37222 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR20; PRR20A; PRR20B; PRR20C; PRR20E Summary This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008] Annotation information Note: This gene is one of five identical loci in a cluster on chromosome 13q21.1. Similar gene clusters are suggested in rhesus, mouse, rabbit, dog, cow, platypus, and armadillo genomic sequences. [25 Jul 2008] Expression Low expression observed in reference dataset See more
PRR20E, Official Symbol PRR20Eprovided by HGNC Official Full Name proline rich 20Eprovided by HGNC Primary source HGNC:HGNC:37223 See related Ensembl:ENSG00000234278 AllianceGenome:HGNC:37223 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR20; PRR20A; PRR20B; PRR20C; PRR20D Summary This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008] Annotation information Note: This gene is one of five identical loci in a cluster on chromosome 13q21.1. Similar gene clusters are suggested in rhesus, mouse, rabbit, dog, cow, platypus, and armadillo genomic sequences. [25 Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
PRR20FP, Official Symbol PRR20FPprovided by HGNC Official Full Name proline rich 20F, pseudogeneprovided by HGNC Primary source HGNC:HGNC:49097 See related Ensembl:ENSG00000271140 AllianceGenome:HGNC:49097 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR20F
PRR20G, Official Symbol PRR20Gprovided by HGNC Official Full Name proline rich 20Gprovided by HGNC Primary source HGNC:HGNC:53837 See related Ensembl:ENSG00000239620 AllianceGenome:HGNC:53837 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs all
PRR22, Official Symbol PRR22provided by HGNC Official Full Name proline rich 22provided by HGNC Primary source HGNC:HGNC:28354 See related Ensembl:ENSG00000212123 AllianceGenome:HGNC:28354 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 10.8), skin (RPKM 1.5) and 13 other tissues See more Orthologs mouse all
PRR23A, Official Symbol PRR23Aprovided by HGNC Official Full Name proline rich 23Aprovided by HGNC Primary source HGNC:HGNC:37172 See related Ensembl:ENSG00000206260 AllianceGenome:HGNC:37172 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs all
PRR23B, Official Symbol PRR23Bprovided by HGNC Official Full Name proline rich 23Bprovided by HGNC Primary source HGNC:HGNC:33764 See related Ensembl:ENSG00000184814 AllianceGenome:HGNC:33764 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs all
PRR23C, Official Symbol PRR23Cprovided by HGNC Official Full Name proline rich 23Cprovided by HGNC Primary source HGNC:HGNC:37173 See related Ensembl:ENSG00000233701 AllianceGenome:HGNC:37173 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Orthologs all
PRR23D1, Official Symbol PRR23D1provided by HGNC Official Full Name proline rich 23 domain containing 1provided by HGNC Primary source HGNC:HGNC:49420 See related Ensembl:ENSG00000255251 AllianceGenome:HGNC:49420 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR23D2 Expression Restricted expression toward testis (RPKM 1.0) See more
PRR23D2, Official Symbol PRR23D2provided by HGNC Official Full Name proline rich 23 domain containing 2provided by HGNC Primary source HGNC:HGNC:49396 See related Ensembl:ENSG00000255378 AllianceGenome:HGNC:49396 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR23D1 Expression Restricted expression toward testis (RPKM 1.1) See more
PRR27, Official Symbol PRR27provided by HGNC Official Full Name proline rich 27provided by HGNC Primary source HGNC:HGNC:33193 See related Ensembl:ENSG00000187533 AllianceGenome:HGNC:33193 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C4orf40 Summary Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward salivary gland (RPKM 399.7) See more Orthologs mouse all
PRR29, Official Symbol PRR29provided by HGNC Official Full Name proline rich 29provided by HGNC Primary source HGNC:HGNC:25673 See related Ensembl:ENSG00000224383 AllianceGenome:HGNC:25673 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C17orf72 Expression Broad expression in spleen (RPKM 19.8), lung (RPKM 9.2) and 19 other tissues See more Orthologs mouse all
PRR29-AS1, Official Symbol PRR29-AS1provided by HGNC Official Full Name PRR29 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51822 See related Ensembl:ENSG00000264954 AllianceGenome:HGNC:51822 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PRR3, Official Symbol PRR3provided by HGNC Official Full Name proline rich 3provided by HGNC Primary source HGNC:HGNC:21149 See related Ensembl:ENSG00000204576 AllianceGenome:HGNC:21149 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAT56 Summary Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 9.9), brain (RPKM 7.4) and 25 other tissues See more Orthologs mouse all
PRR30, Official Symbol PRR30provided by HGNC Official Full Name proline rich 30provided by HGNC Primary source HGNC:HGNC:28677 See related Ensembl:ENSG00000186143 AllianceGenome:HGNC:28677 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf53 Expression Restricted expression toward testis (RPKM 44.2) See more Orthologs mouse all
PRR32, Official Symbol PRR32provided by HGNC Official Full Name proline rich 32provided by HGNC Primary source HGNC:HGNC:34498 See related Ensembl:ENSG00000183631 AllianceGenome:HGNC:34498 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CXorf64 Expression Low expression observed in reference dataset See more Orthologs mouse all
PRR33, Official Symbol PRR33provided by HGNC Official Full Name proline rich 33provided by HGNC Primary source HGNC:HGNC:35118 See related Ensembl:ENSG00000283787 AllianceGenome:HGNC:35118 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C11orf89 Summary Predicted to act upstream of or within response to wounding. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
PRR34-AS1, Official Symbol PRR34-AS1provided by HGNC Official Full Name PRR34 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50499 See related AllianceGenome:HGNC:50499 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in kidney (RPKM 2.4), fat (RPKM 2.3) and 25 other tissues See more
PRR35, Official Symbol PRR35provided by HGNC Official Full Name proline rich 35provided by HGNC Primary source HGNC:HGNC:14139 See related Ensembl:ENSG00000161992 AllianceGenome:HGNC:14139 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C16orf11; LA16c-366D1.2 Expression Restricted expression toward kidney (RPKM 3.0) See more Orthologs mouse all
PRR36, Official Symbol PRR36provided by HGNC Official Full Name proline rich 36provided by HGNC Primary source HGNC:HGNC:26172 See related Ensembl:ENSG00000183248 AllianceGenome:HGNC:26172 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013] Expression Biased expression in brain (RPKM 7.2), prostate (RPKM 1.1) and 4 other tissues See more Orthologs mouse all
PRR4, Official Symbol PRR4provided by HGNC Official Full Name proline rich 4provided by HGNC Primary source HGNC:HGNC:18020 See related Ensembl:ENSG00000111215 MIM:605359; AllianceGenome:HGNC:18020 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LPRP; PROL4 Summary This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011] Expression Restricted expression toward salivary gland (RPKM 1815.0) See more Orthologs all
PRR5, Official Symbol PRR5provided by HGNC Official Full Name proline rich 5provided by HGNC Primary source HGNC:HGNC:31682 See related Ensembl:ENSG00000186654 MIM:609406; AllianceGenome:HGNC:31682 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP610; PROTOR1; PROTOR-1; FLJ20185k Summary This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010] Expression Broad expression in fat (RPKM 9.7), spleen (RPKM 8.6) and 23 other tissues See more Orthologs mouse all
PRR5-ARHGAP8, Official Symbol PRR5-ARHGAP8provided by HGNC Official Full Name PRR5-ARHGAP8 readthroughprovided by HGNC Primary source HGNC:HGNC:34512 See related Ensembl:ENSG00000248405 AllianceGenome:HGNC:34512 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2010] Expression Broad expression in kidney (RPKM 5.8), spleen (RPKM 4.9) and 21 other tissues See more
PRR5L, Official Symbol PRR5Lprovided by HGNC Official Full Name proline rich 5 likeprovided by HGNC Primary source HGNC:HGNC:25878 See related Ensembl:ENSG00000135362 MIM:611728; AllianceGenome:HGNC:25878 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PROTOR2 Summary Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; positive regulation of mRNA catabolic process; and regulation of fibroblast migration. Part of TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 11.6), colon (RPKM 10.9) and 19 other tissues See more Orthologs mouse all
PRR7, Official Symbol PRR7provided by HGNC Official Full Name proline rich 7, synapticprovided by HGNC Primary source HGNC:HGNC:28130 See related Ensembl:ENSG00000131188 MIM:618306; AllianceGenome:HGNC:28130 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Enables long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in bone marrow (RPKM 2.0), brain (RPKM 0.9) and 12 other tissues See more Orthologs mouse all
PRR9, Official Symbol PRR9provided by HGNC Official Full Name proline rich 9provided by HGNC Primary source HGNC:HGNC:32057 See related Ensembl:ENSG00000203783 AllianceGenome:HGNC:32057 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more Orthologs mouse all
PRRC1, Official Symbol PRRC1provided by HGNC Official Full Name proline rich coiled-coil 1provided by HGNC Primary source HGNC:HGNC:28164 See related Ensembl:ENSG00000164244 AllianceGenome:HGNC:28164 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable identical protein binding activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in activation of protein kinase A activity. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 18.8), endometrium (RPKM 14.7) and 25 other tissues See more Orthologs mouse all