psui3905/ncbi_genes_summary huggingface dataset:
PKD1P6-NPIPP1, Gene symbol PKD1P6-NPIPP1 Gene description PKD1P6-NPIPP1 readthrough See related Ensembl:ENSG00000270580 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This locus represents naturally-occurring readthrough transcription between two unprocessed pseudogenes, PKD1P6 (polycystic kidney disease 1 (autosomal dominant) pseudogene 6) and NPIPP1 (nuclear pore complex interacting protein pseudogene 1). The individual pseudogene loci are not curated as transcribed regions. Readthrough transcripts likely do not encode functional proteins. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in skin (RPKM 36.1), ovary (RPKM 33.7) and 25 other tissues See more Orthologs all
PKD2, Official Symbol PKD2provided by HGNC Official Full Name polycystin 2, transient receptor potential cation channelprovided by HGNC Primary source HGNC:HGNC:9009 See related Ensembl:ENSG00000118762 MIM:173910; AllianceGenome:HGNC:9009 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PC2; PKD4; Pc-2; APKD2; TRPP2 Summary This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011] Annotation information Note: PKD2 (GeneID: 5311) and PRKD2 (GeneID: 25865) share the PKD2 symbol/alias in common. PKD2 is a widely used alternative name for protein kinase D2 (PRKD2), which can be confused with the official symbol for PKD2/polycystin-2/polycystic kidney disease 2. [19 Jun 2018] Expression Ubiquitous expression in endometrium (RPKM 27.5), kidney (RPKM 19.2) and 25 other tissues See more Orthologs mouse all
PKD2L1, Official Symbol PKD2L1provided by HGNC Official Full Name polycystin 2 like 1, transient receptor potential cation channelprovided by HGNC Primary source HGNC:HGNC:9011 See related Ensembl:ENSG00000107593 MIM:604532; AllianceGenome:HGNC:9011 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCL; PKDL; PKD2L; TRPP3 Summary This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Expression Biased expression in spleen (RPKM 1.0), testis (RPKM 0.9) and 7 other tissues See more Orthologs mouse all
PKD2L2, Official Symbol PKD2L2provided by HGNC Official Full Name polycystin 2 like 2, transient receptor potential cation channelprovided by HGNC Primary source HGNC:HGNC:9012 See related Ensembl:ENSG00000078795 MIM:604669; AllianceGenome:HGNC:9012 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TRPP5 Summary Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 6.7), endometrium (RPKM 3.3) and 24 other tissues See more Orthologs mouse all
PKDCC, Official Symbol PKDCCprovided by HGNC Official Full Name protein kinase domain containing, cytoplasmicprovided by HGNC Primary source HGNC:HGNC:25123 See related Ensembl:ENSG00000162878 MIM:614150; AllianceGenome:HGNC:25123 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Vlk; RLSDF; SGK493 Summary Enables non-membrane spanning protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation and skeletal system development. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in ovary (RPKM 28.2), endometrium (RPKM 26.6) and 22 other tissues See more Orthologs mouse all
PKDREJ, Official Symbol PKDREJprovided by HGNC Official Full Name polycystin family receptor for egg jellyprovided by HGNC Primary source HGNC:HGNC:9015 See related Ensembl:ENSG00000130943 MIM:604670; AllianceGenome:HGNC:9015 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008] Orthologs mouse all
PKHD1, Official Symbol PKHD1provided by HGNC Official Full Name PKHD1 ciliary IPT domain containing fibrocystin/polyductinprovided by HGNC Primary source HGNC:HGNC:9016 See related Ensembl:ENSG00000170927 MIM:606702; AllianceGenome:HGNC:9016 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FPC; FCYT; PKD4; ARPKD; TIGM1 Summary The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 4.0), pancreas (RPKM 0.7) and 2 other tissues See more Orthologs mouse all
PKHD1L1, Official Symbol PKHD1L1provided by HGNC Official Full Name PKHD1 like 1provided by HGNC Primary source HGNC:HGNC:20313 See related Ensembl:ENSG00000205038 MIM:607843; AllianceGenome:HGNC:20313 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKHDL1 Summary Predicted to act upstream of or within sensory perception of sound. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in thyroid (RPKM 10.5) and lymph node (RPKM 0.8) See more Orthologs mouse all
PKIA, Official Symbol PKIAprovided by HGNC Official Full Name cAMP-dependent protein kinase inhibitor alphaprovided by HGNC Primary source HGNC:HGNC:9017 See related Ensembl:ENSG00000171033 MIM:606059; AllianceGenome:HGNC:9017 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRKACN1 Summary The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] Expression Biased expression in heart (RPKM 28.1), brain (RPKM 26.1) and 11 other tissues See more Orthologs mouse all
PKIA-AS1, Official Symbol PKIA-AS1provided by HGNC Official Full Name PKIA antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51659 See related Ensembl:ENSG00000254266 AllianceGenome:HGNC:51659 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PKIB, Official Symbol PKIBprovided by HGNC Official Full Name cAMP-dependent protein kinase inhibitor betaprovided by HGNC Primary source HGNC:HGNC:9018 See related Ensembl:ENSG00000135549 MIM:606914; AllianceGenome:HGNC:9018 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRKACN2 Summary This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Expression Biased expression in colon (RPKM 18.8), placenta (RPKM 15.5) and 10 other tissues See more Orthologs mouse all
PKIG, Official Symbol PKIGprovided by HGNC Official Full Name cAMP-dependent protein kinase inhibitor gammaprovided by HGNC Primary source HGNC:HGNC:9019 See related Ensembl:ENSG00000168734 MIM:604932; AllianceGenome:HGNC:9019 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PKI-gamma Summary This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Ubiquitous expression in heart (RPKM 51.1), urinary bladder (RPKM 28.8) and 24 other tissues See more Orthologs mouse all
PKLR, Official Symbol PKLRprovided by HGNC Official Full Name pyruvate kinase L/Rprovided by HGNC Primary source HGNC:HGNC:9020 See related Ensembl:ENSG00000143627 MIM:609712; AllianceGenome:HGNC:9020 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PK1; PKL; RPK; PKRL Summary The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 34.0), kidney (RPKM 20.1) and 3 other tissues See more Orthologs mouse all
PKM, Official Symbol PKMprovided by HGNC Official Full Name pyruvate kinase M1/2provided by HGNC Primary source HGNC:HGNC:9021 See related Ensembl:ENSG00000067225 MIM:179050; AllianceGenome:HGNC:9021 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PK3; TCB; p58; OIP3; PKM2; CTHBP; THBP1; HEL-S-30 Summary This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011] Expression Ubiquitous expression in brain (RPKM 155.4), esophagus (RPKM 151.3) and 24 other tissues See more Orthologs mouse all
PKMP3, Official Symbol PKMP3provided by HGNC Official Full Name pyruvate kinase M1/2 pseudogene 3provided by HGNC Primary source HGNC:HGNC:44245 See related Ensembl:ENSG00000220563 AllianceGenome:HGNC:44245 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PKMYT1, Official Symbol PKMYT1provided by HGNC Official Full Name protein kinase, membrane associated tyrosine/threonine 1provided by HGNC Primary source HGNC:HGNC:29650 See related Ensembl:ENSG00000127564 MIM:602474; AllianceGenome:HGNC:29650 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYT1; PPP1R126 Summary This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] Expression Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues See more Orthologs mouse all
PKN1, Official Symbol PKN1provided by HGNC Official Full Name protein kinase N1provided by HGNC Primary source HGNC:HGNC:9405 See related Ensembl:ENSG00000123143 MIM:601032; AllianceGenome:HGNC:9405 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA Summary The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 39.4), fat (RPKM 30.1) and 25 other tissues See more Orthologs mouse all
PKN2, Official Symbol PKN2provided by HGNC Official Full Name protein kinase N2provided by HGNC Primary source HGNC:HGNC:9406 See related Ensembl:ENSG00000065243 MIM:602549; AllianceGenome:HGNC:9406 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042 Summary Enables RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apical junction assembly; positive regulation of cell cycle; and positive regulation of viral genome replication. Located in several cellular components, including cleavage furrow; cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in ovary (RPKM 11.1), duodenum (RPKM 10.9) and 25 other tissues See more Orthologs mouse all
PKN2-AS1, Official Symbol PKN2-AS1provided by HGNC Official Full Name PKN2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50597 See related Ensembl:ENSG00000237505 AllianceGenome:HGNC:50597 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PKN3, Official Symbol PKN3provided by HGNC Official Full Name protein kinase N3provided by HGNC Primary source HGNC:HGNC:17999 See related Ensembl:ENSG00000160447 MIM:610714; AllianceGenome:HGNC:17999 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UTDP4-1 Summary Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 3.9), lung (RPKM 3.1) and 25 other tissues See more Orthologs mouse all
PKNOX1, Official Symbol PKNOX1provided by HGNC Official Full Name PBX/knotted 1 homeobox 1provided by HGNC Primary source HGNC:HGNC:9022 See related Ensembl:ENSG00000160199 MIM:602100; AllianceGenome:HGNC:9022 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PREP1; pkonx1c Summary Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in angiogenesis and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within camera-type eye development; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
PKNOX2, Official Symbol PKNOX2provided by HGNC Official Full Name PBX/knotted 1 homeobox 2provided by HGNC Primary source HGNC:HGNC:16714 See related Ensembl:ENSG00000165495 MIM:613066; AllianceGenome:HGNC:16714 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PREP2 Summary Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009] Expression Broad expression in thyroid (RPKM 4.8), ovary (RPKM 4.1) and 21 other tissues See more Orthologs mouse all
PKNOX2-AS1, Official Symbol PKNOX2-AS1provided by HGNC Official Full Name PKNOX2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:56709 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PKP1, Official Symbol PKP1provided by HGNC Official Full Name plakophilin 1provided by HGNC Primary source HGNC:HGNC:9023 See related Ensembl:ENSG00000081277 MIM:601975; AllianceGenome:HGNC:9023 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B6P; EDSFS Summary This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] Expression Biased expression in skin (RPKM 358.6) and esophagus (RPKM 152.0) See more Orthologs mouse all
PKP2, Official Symbol PKP2provided by HGNC Official Full Name plakophilin 2provided by HGNC Primary source HGNC:HGNC:9024 See related Ensembl:ENSG00000057294 MIM:602861; AllianceGenome:HGNC:9024 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARVD9 Summary This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13. [provided by RefSeq, May 2022] Expression Biased expression in heart (RPKM 72.8), colon (RPKM 29.6) and 12 other tissues See more Orthologs mouse all
PKP3, Official Symbol PKP3provided by HGNC Official Full Name plakophilin 3provided by HGNC Primary source HGNC:HGNC:9025 See related Ensembl:ENSG00000184363 MIM:605561; AllianceGenome:HGNC:9025 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] Expression Biased expression in skin (RPKM 51.4), esophagus (RPKM 46.7) and 11 other tissues See more Orthologs mouse all
PKP4, Official Symbol PKP4provided by HGNC Official Full Name plakophilin 4provided by HGNC Primary source HGNC:HGNC:9026 See related Ensembl:ENSG00000144283 MIM:604276; AllianceGenome:HGNC:9026 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p0071 Summary Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] Expression Ubiquitous expression in kidney (RPKM 22.9), thyroid (RPKM 17.0) and 25 other tissues See more Orthologs mouse all
PKP4-AS1, Official Symbol PKP4-AS1provided by HGNC Official Full Name PKP4 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:52580 See related Ensembl:ENSG00000204380 AllianceGenome:HGNC:52580 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in kidney (RPKM 1.5), brain (RPKM 1.3) and 25 other tissues See more
PLA1A, Official Symbol PLA1Aprovided by HGNC Official Full Name phospholipase A1 member Aprovided by HGNC Primary source HGNC:HGNC:17661 See related Ensembl:ENSG00000144837 MIM:607460; AllianceGenome:HGNC:17661 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSPLA1; PS-PLA1 Summary The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] Expression Broad expression in liver (RPKM 8.5), lymph node (RPKM 6.1) and 17 other tissues See more Orthologs mouse all
PLA2G10, Official Symbol PLA2G10provided by HGNC Official Full Name phospholipase A2 group Xprovided by HGNC Primary source HGNC:HGNC:9029 See related Ensembl:ENSG00000069764 MIM:603603; AllianceGenome:HGNC:9029 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPLA2; GXPLA2; GXSPLA2; sPLA2-X Summary This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015] Expression Biased expression in stomach (RPKM 10.4), colon (RPKM 7.1) and 6 other tissues See more Orthologs mouse all
PLA2G12A, Official Symbol PLA2G12Aprovided by HGNC Official Full Name phospholipase A2 group XIIAprovided by HGNC Primary source HGNC:HGNC:18554 See related Ensembl:ENSG00000123739 MIM:611652; AllianceGenome:HGNC:18554 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GXII; ROSSY; PLA2G12 Summary Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in thyroid (RPKM 11.6), prostate (RPKM 9.6) and 25 other tissues See more Orthologs mouse all
PLA2G12AP1, Official Symbol PLA2G12AP1provided by HGNC Official Full Name phospholipase A2 group XIIA pseudogene 1provided by HGNC Primary source HGNC:HGNC:39248 See related AllianceGenome:HGNC:39248 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PLA2G12B, Official Symbol PLA2G12Bprovided by HGNC Official Full Name phospholipase A2 group XIIBprovided by HGNC Primary source HGNC:HGNC:18555 See related Ensembl:ENSG00000138308 MIM:611653; AllianceGenome:HGNC:18555 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GXIIB; FKSG71; PLA2G13; GXIIIsPLA2; sPLA2-GXIIB Summary The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in liver (RPKM 15.3), small intestine (RPKM 14.6) and 5 other tissues See more Orthologs mouse all
PLA2G15, Official Symbol PLA2G15provided by HGNC Official Full Name phospholipase A2 group XVprovided by HGNC Primary source HGNC:HGNC:17163 See related Ensembl:ENSG00000103066 MIM:609362; AllianceGenome:HGNC:17163 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACS; LLPL; LPLA2; LYPLA3; GXVPLA2 Summary Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 17.1), heart (RPKM 11.8) and 25 other tissues See more Orthologs mouse all
PLA2G1B, Official Symbol PLA2G1Bprovided by HGNC Official Full Name phospholipase A2 group IBprovided by HGNC Primary source HGNC:HGNC:9030 See related Ensembl:ENSG00000170890 MIM:172410; AllianceGenome:HGNC:9030 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLA2; PLA2A; PPLA2 Summary This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013] Expression Restricted expression toward pancreas (RPKM 9662.9) See more Orthologs mouse all
PLA2G2A, Official Symbol PLA2G2Aprovided by HGNC Official Full Name phospholipase A2 group IIAprovided by HGNC Primary source HGNC:HGNC:9031 See related Ensembl:ENSG00000188257 MIM:172411; AllianceGenome:HGNC:9031 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2 Summary The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009] Expression Biased expression in colon (RPKM 828.3), small intestine (RPKM 526.6) and 7 other tissues See more Orthologs mouse all
PLA2G2C, Official Symbol PLA2G2Cprovided by HGNC Official Full Name phospholipase A2 group IICprovided by HGNC Primary source HGNC:HGNC:9032 See related Ensembl:ENSG00000187980 AllianceGenome:HGNC:9032 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBXN10-AS1 Summary Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in phospholipid metabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
PLA2G2D, Official Symbol PLA2G2Dprovided by HGNC Official Full Name phospholipase A2 group IIDprovided by HGNC Primary source HGNC:HGNC:9033 See related Ensembl:ENSG00000117215 MIM:605630; AllianceGenome:HGNC:9033 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPLASH; sPLA2S; PLA2IID; sPLA2-IID Summary This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] Expression Biased expression in lymph node (RPKM 63.3), appendix (RPKM 10.7) and 2 other tissues See more Orthologs all
PLA2G2E, Official Symbol PLA2G2Eprovided by HGNC Official Full Name phospholipase A2 group IIEprovided by HGNC Primary source HGNC:HGNC:13414 See related Ensembl:ENSG00000188784 MIM:618320; AllianceGenome:HGNC:13414 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as sPLA2-IIE; GIIE sPLA2 Summary Enables calcium ion binding activity and calcium-dependent phospholipase A2 activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within low-density lipoprotein particle remodeling. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
PLA2G2F, Official Symbol PLA2G2Fprovided by HGNC Official Full Name phospholipase A2 group IIFprovided by HGNC Primary source HGNC:HGNC:30040 See related Ensembl:ENSG00000158786 MIM:616793; AllianceGenome:HGNC:30040 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GIIFsPLA2; sPLA2-IIF Summary Enables calcium-dependent phospholipase A2 activity. Involved in glycerophospholipid metabolic process. Predicted to be located in cytosol and extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 4.4), urinary bladder (RPKM 2.2) and 1 other tissue See more Orthologs mouse all
PLA2G3, Official Symbol PLA2G3provided by HGNC Official Full Name phospholipase A2 group IIIprovided by HGNC Primary source HGNC:HGNC:17934 See related Ensembl:ENSG00000100078 MIM:611651; AllianceGenome:HGNC:17934 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPLA2III; sPLA2-III; GIII-SPLA2 Summary This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014] Expression Biased expression in skin (RPKM 3.5), esophagus (RPKM 1.9) and 4 other tissues See more Orthologs mouse all
PLA2G4A, Official Symbol PLA2G4Aprovided by HGNC Official Full Name phospholipase A2 group IVAprovided by HGNC Primary source HGNC:HGNC:9035 See related Ensembl:ENSG00000116711 MIM:600522; AllianceGenome:HGNC:9035 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GURDP; cPLA2; PLA2G4; cPLA2-alpha Summary This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] Expression Ubiquitous expression in urinary bladder (RPKM 6.0), adrenal (RPKM 5.6) and 24 other tissues See more Orthologs mouse all
PLA2G4B, Official Symbol PLA2G4Bprovided by HGNC Official Full Name phospholipase A2 group IVBprovided by HGNC Primary source HGNC:HGNC:9036 See related Ensembl:ENSG00000243708 MIM:606088; AllianceGenome:HGNC:9036 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HsT16992; cPLA2-beta Summary This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 29.6), esophagus (RPKM 11.9) and 23 other tissues See more Orthologs mouse all
PLA2G4C, Official Symbol PLA2G4Cprovided by HGNC Official Full Name phospholipase A2 group IVCprovided by HGNC Primary source HGNC:HGNC:9037 See related Ensembl:ENSG00000105499 MIM:603602; AllianceGenome:HGNC:9037 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPLA2-gamma Summary This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] Expression Ubiquitous expression in brain (RPKM 6.1), heart (RPKM 5.7) and 23 other tissues See more Orthologs mouse all
PLA2G4C-AS1, Official Symbol PLA2G4C-AS1provided by HGNC Official Full Name PLA2G4C antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51585 See related Ensembl:ENSG00000269420 AllianceGenome:HGNC:51585 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in brain (RPKM 1.9), heart (RPKM 1.8) and 24 other tissues See more
PLA2G4D, Official Symbol PLA2G4Dprovided by HGNC Official Full Name phospholipase A2 group IVDprovided by HGNC Primary source HGNC:HGNC:30038 See related Ensembl:ENSG00000159337 MIM:612864; AllianceGenome:HGNC:30038 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as cPLA2delta Summary The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009] Expression Biased expression in skin (RPKM 6.8), prostate (RPKM 6.7) and 2 other tissues See more Orthologs mouse all
PLA2G4E, Official Symbol PLA2G4Eprovided by HGNC Official Full Name phospholipase A2 group IVEprovided by HGNC Primary source HGNC:HGNC:24791 See related Ensembl:ENSG00000188089 AllianceGenome:HGNC:24791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017] Expression Restricted expression toward skin (RPKM 22.1) See more Orthologs mouse all
PLA2G4E-AS1, Official Symbol PLA2G4E-AS1provided by HGNC Official Full Name PLA2G4E antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51419 See related Ensembl:ENSG00000246740 AllianceGenome:HGNC:51419 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in skin (RPKM 4.3) and testis (RPKM 0.3) See more
PLA2G4F, Official Symbol PLA2G4Fprovided by HGNC Official Full Name phospholipase A2 group IVFprovided by HGNC Primary source HGNC:HGNC:27396 See related Ensembl:ENSG00000168907 AllianceGenome:HGNC:27396 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLA2G4FZ Summary Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in glycerophospholipid catabolic process. Predicted to act upstream of or within several processes, including arachidonic acid secretion; cellular response to antibiotic; and prostaglandin biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol; ruffle membrane; and vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in skin (RPKM 54.3), lung (RPKM 12.6) and 6 other tissues See more Orthologs mouse all