psui3905/ncbi_genes_summary huggingface dataset:
CDK1, Official Symbol CDK1provided by HGNC Official Full Name cyclin dependent kinase 1provided by HGNC Primary source HGNC:HGNC:1722 See related Ensembl:ENSG00000170312 MIM:116940; AllianceGenome:HGNC:1722 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC2; CDC28A; P34CDC2 Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023] Expression Broad expression in lymph node (RPKM 12.8), bone marrow (RPKM 12.8) and 18 other tissues See more Orthologs mouse all
CDK10, Official Symbol CDK10provided by HGNC Official Full Name cyclin dependent kinase 10provided by HGNC Primary source HGNC:HGNC:1770 See related Ensembl:ENSG00000185324 MIM:603464; AllianceGenome:HGNC:1770 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ALSAS; PISSLRE Summary The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] Expression Ubiquitous expression in duodenum (RPKM 16.8), thyroid (RPKM 15.2) and 25 other tissues See more Orthologs mouse all
CDK11A, Official Symbol CDK11Aprovided by HGNC Official Full Name cyclin dependent kinase 11Aprovided by HGNC Primary source HGNC:HGNC:1730 See related Ensembl:ENSG00000008128 MIM:116951; AllianceGenome:HGNC:1730 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110 Summary This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues See more Orthologs all
CDK11B, Official Symbol CDK11Bprovided by HGNC Official Full Name cyclin dependent kinase 11Bprovided by HGNC Primary source HGNC:HGNC:1729 See related Ensembl:ENSG00000248333 MIM:176873; AllianceGenome:HGNC:1729 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p58; PK58; CDK11; CLK-1; CDC2L1; PITSLREA; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110 Summary This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Ubiquitous expression in testis (RPKM 20.1), bone marrow (RPKM 18.4) and 25 other tissues See more Orthologs mouse all
CDK12, Official Symbol CDK12provided by HGNC Official Full Name cyclin dependent kinase 12provided by HGNC Primary source HGNC:HGNC:24224 See related Ensembl:ENSG00000167258 MIM:615514; AllianceGenome:HGNC:24224 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRK7; CRKR; CRKRS Summary Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 8.6), bone marrow (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
CDK13, Official Symbol CDK13provided by HGNC Official Full Name cyclin dependent kinase 13provided by HGNC Primary source HGNC:HGNC:1733 See related Ensembl:ENSG00000065883 MIM:603309; AllianceGenome:HGNC:1733 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CHED; CDC2L; CDC2L5; hCDK13; CHDFIDD Summary The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009] Expression Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
CDK14, Official Symbol CDK14provided by HGNC Official Full Name cyclin dependent kinase 14provided by HGNC Primary source HGNC:HGNC:8883 See related Ensembl:ENSG00000058091 MIM:610679; AllianceGenome:HGNC:8883 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFTK1; PFTAIRE1 Summary Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in G2/M transition of mitotic cell cycle and regulation of canonical Wnt signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.5), kidney (RPKM 3.1) and 24 other tissues See more Orthologs mouse all
CDK15, Official Symbol CDK15provided by HGNC Official Full Name cyclin dependent kinase 15provided by HGNC Primary source HGNC:HGNC:14434 See related Ensembl:ENSG00000138395 MIM:616147; AllianceGenome:HGNC:14434 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PFTK2; ALS2CR7; PFTAIRE2 Summary Enables protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in ovary (RPKM 1.2), gall bladder (RPKM 0.5) and 13 other tissues See more Orthologs mouse all
CDK16, Official Symbol CDK16provided by HGNC Official Full Name cyclin dependent kinase 16provided by HGNC Primary source HGNC:HGNC:8749 See related Ensembl:ENSG00000102225 MIM:311550; AllianceGenome:HGNC:8749 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE Summary The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009] Expression Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 14.2) and 25 other tissues See more Orthologs mouse all
CDK17, Official Symbol CDK17provided by HGNC Official Full Name cyclin dependent kinase 17provided by HGNC Primary source HGNC:HGNC:8750 See related Ensembl:ENSG00000059758 MIM:603440; AllianceGenome:HGNC:8750 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCTK2; PCTAIRE2 Summary The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues See more Orthologs mouse all
CDK18, Official Symbol CDK18provided by HGNC Official Full Name cyclin dependent kinase 18provided by HGNC Primary source HGNC:HGNC:8751 See related Ensembl:ENSG00000117266 MIM:169190; AllianceGenome:HGNC:8751 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PCTK3; PCTAIRE; PCTAIRE3 Summary Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in heart (RPKM 26.3), brain (RPKM 20.4) and 20 other tissues See more Orthologs mouse all
CDK19, Official Symbol CDK19provided by HGNC Official Full Name cyclin dependent kinase 19provided by HGNC Primary source HGNC:HGNC:19338 See related Ensembl:ENSG00000155111 MIM:614720; AllianceGenome:HGNC:19338 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDK11; DEE87; CDC2L6; EIEE87; bA346C16.3 Summary This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] Expression Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues See more Orthologs mouse all
CDK2, Official Symbol CDK2provided by HGNC Official Full Name cyclin dependent kinase 2provided by HGNC Primary source HGNC:HGNC:1771 See related Ensembl:ENSG00000123374 MIM:116953; AllianceGenome:HGNC:1771 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDKN2; p33(CDK2) Summary This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Ubiquitous expression in placenta (RPKM 29.3), bone marrow (RPKM 14.9) and 24 other tissues See more Orthologs mouse all
CDK20, Official Symbol CDK20provided by HGNC Official Full Name cyclin dependent kinase 20provided by HGNC Primary source HGNC:HGNC:21420 See related Ensembl:ENSG00000156345 MIM:610076; AllianceGenome:HGNC:21420 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P42; CCRK; CDCH; PNQALRE Summary The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009] Expression Broad expression in testis (RPKM 10.2), adrenal (RPKM 7.6) and 24 other tissues See more Orthologs mouse all
CDK2AP1, Official Symbol CDK2AP1provided by HGNC Official Full Name cyclin dependent kinase 2 associated protein 1provided by HGNC Primary source HGNC:HGNC:14002 See related Ensembl:ENSG00000111328 MIM:602198; AllianceGenome:HGNC:14002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DOC1; ST19; DORC1; doc-1; p12DOC-1 Summary The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] Expression Ubiquitous expression in brain (RPKM 57.9), endometrium (RPKM 35.8) and 25 other tissues See more Orthologs mouse all
CDK2AP2, Official Symbol CDK2AP2provided by HGNC Official Full Name cyclin dependent kinase 2 associated protein 2provided by HGNC Primary source HGNC:HGNC:30833 See related Ensembl:ENSG00000167797 MIM:620061; AllianceGenome:HGNC:30833 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p14; DOC1R; DOC-1R Summary This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in thyroid (RPKM 21.4), adrenal (RPKM 15.6) and 25 other tissues See more Orthologs mouse all
CDK3, Official Symbol CDK3provided by HGNC Official Full Name cyclin dependent kinase 3provided by HGNC Primary source HGNC:HGNC:1772 See related Ensembl:ENSG00000250506 MIM:123828; AllianceGenome:HGNC:1772 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 8.9), small intestine (RPKM 6.9) and 25 other tissues See more Orthologs all
CDK4, Official Symbol CDK4provided by HGNC Official Full Name cyclin dependent kinase 4provided by HGNC Primary source HGNC:HGNC:1773 See related Ensembl:ENSG00000135446 MIM:123829; AllianceGenome:HGNC:1773 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMM3; PSK-J3 Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 35.9) and 25 other tissues See more Orthologs mouse all
CDK4P1, Official Symbol CDK4P1provided by HGNC Official Full Name cyclin dependent kinase 4 pseudogene 1provided by HGNC Primary source HGNC:HGNC:19040 See related Ensembl:ENSG00000225036 AllianceGenome:HGNC:19040 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDK4PS
CDK5, Official Symbol CDK5provided by HGNC Official Full Name cyclin dependent kinase 5provided by HGNC Primary source HGNC:HGNC:1774 See related Ensembl:ENSG00000164885 MIM:123831; AllianceGenome:HGNC:1774 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIS7; PSSALRE Summary This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] Expression Ubiquitous expression in brain (RPKM 18.5), adrenal (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
CDK5P1, Official Symbol CDK5P1provided by HGNC Official Full Name cyclin dependent kinase 5 pseudogene 1provided by HGNC Primary source HGNC:HGNC:21261 See related Ensembl:ENSG00000235165 AllianceGenome:HGNC:21261 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDK5PS
CDK5R1, Official Symbol CDK5R1provided by HGNC Official Full Name cyclin dependent kinase 5 regulatory subunit 1provided by HGNC Primary source HGNC:HGNC:1775 See related Ensembl:ENSG00000176749 MIM:603460; AllianceGenome:HGNC:1775 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a Summary The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 36.6), lymph node (RPKM 6.6) and 5 other tissues See more Orthologs mouse all
CDK5R2, Official Symbol CDK5R2provided by HGNC Official Full Name cyclin dependent kinase 5 regulatory subunit 2provided by HGNC Primary source HGNC:HGNC:1776 See related Ensembl:ENSG00000171450 MIM:603764; AllianceGenome:HGNC:1776 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P39; NCK5AI; p39nck5ai Summary The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008] Orthologs mouse all
CDK5RAP1, Official Symbol CDK5RAP1provided by HGNC Official Full Name CDK5 regulatory subunit associated protein 1provided by HGNC Primary source HGNC:HGNC:15880 See related Ensembl:ENSG00000101391 MIM:608200; AllianceGenome:HGNC:15880 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C42; CGI-05; HSPC167; C20orf34 Summary This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013] Expression Ubiquitous expression in thyroid (RPKM 5.1), bone marrow (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
CDK5RAP2, Official Symbol CDK5RAP2provided by HGNC Official Full Name CDK5 regulatory subunit associated protein 2provided by HGNC Primary source HGNC:HGNC:18672 See related Ensembl:ENSG00000136861 MIM:608201; AllianceGenome:HGNC:18672 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C48; MCPH3; Cep215 Summary This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] Expression Ubiquitous expression in testis (RPKM 15.8), bone marrow (RPKM 9.3) and 25 other tissues See more Orthologs mouse all
CDK5RAP3, Official Symbol CDK5RAP3provided by HGNC Official Full Name CDK5 regulatory subunit associated protein 3provided by HGNC Primary source HGNC:HGNC:18673 See related Ensembl:ENSG00000108465 MIM:608202; AllianceGenome:HGNC:18673 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114 Summary This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013] Expression Ubiquitous expression in spleen (RPKM 44.2), lymph node (RPKM 40.3) and 25 other tissues See more Orthologs mouse all
CDK6, Official Symbol CDK6provided by HGNC Official Full Name cyclin dependent kinase 6provided by HGNC Primary source HGNC:HGNC:1777 See related Ensembl:ENSG00000105810 MIM:603368; AllianceGenome:HGNC:1777 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MCPH12; PLSTIRE Summary The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017] Expression Ubiquitous expression in placenta (RPKM 9.3), bone marrow (RPKM 7.6) and 25 other tissues See more Orthologs mouse all
CDK6-AS1, Official Symbol CDK6-AS1provided by HGNC Official Full Name CDK6 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40141 See related Ensembl:ENSG00000237819 AllianceGenome:HGNC:40141 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BALR-2 Expression Biased expression in bone marrow (RPKM 1.0), testis (RPKM 0.3) and 11 other tissues See more
CDK7, Official Symbol CDK7provided by HGNC Official Full Name cyclin dependent kinase 7provided by HGNC Primary source HGNC:HGNC:1778 See related Ensembl:ENSG00000134058 MIM:601955; AllianceGenome:HGNC:1778 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15 Summary The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 18.1), placenta (RPKM 14.9) and 25 other tissues See more Orthologs mouse all
CDK7P1, Official Symbol CDK7P1provided by HGNC Official Full Name cyclin dependent kinase 7 pseudogene 1provided by HGNC Primary source HGNC:HGNC:18614 See related AllianceGenome:HGNC:18614 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDK7PS
CDK8, Official Symbol CDK8provided by HGNC Official Full Name cyclin dependent kinase 8provided by HGNC Primary source HGNC:HGNC:1779 See related Ensembl:ENSG00000132964 MIM:603184; AllianceGenome:HGNC:1779 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as K35; IDDHBA Summary This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] Expression Ubiquitous expression in testis (RPKM 6.1), duodenum (RPKM 3.9) and 25 other tissues See more Orthologs mouse all
CDK8P1, Official Symbol CDK8P1provided by HGNC Official Full Name cyclin dependent kinase 8 pseudogene 1provided by HGNC Primary source HGNC:HGNC:18995 See related Ensembl:ENSG00000230044 AllianceGenome:HGNC:18995 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDK8PS
CDK9, Official Symbol CDK9provided by HGNC Official Full Name cyclin dependent kinase 9provided by HGNC Primary source HGNC:HGNC:1780 See related Ensembl:ENSG00000136807 MIM:603251; AllianceGenome:HGNC:1780 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TAK; C-2k; CTK1; CDC2L4; PITALRE Summary The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 32.0), spleen (RPKM 23.0) and 25 other tissues See more Orthologs mouse all
CDKAL1, Official Symbol CDKAL1provided by HGNC Official Full Name CDK5 regulatory subunit associated protein 1 like 1provided by HGNC Primary source HGNC:HGNC:21050 See related Ensembl:ENSG00000145996 MIM:611259; AllianceGenome:HGNC:21050 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010] Expression Ubiquitous expression in thyroid (RPKM 1.8), endometrium (RPKM 1.4) and 25 other tissues See more Orthologs mouse all
CDKL1, Official Symbol CDKL1provided by HGNC Official Full Name cyclin dependent kinase like 1provided by HGNC Primary source HGNC:HGNC:1781 See related Ensembl:ENSG00000100490 MIM:603441; AllianceGenome:HGNC:1781 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P42; KKIALRE Summary This gene product is a member of a large family of CDC2-related serine/threonine protein kinases that accumulates primarily in the nucleus. [provided by RefSeq, Nov 2018] Expression Ubiquitous expression in kidney (RPKM 3.9), endometrium (RPKM 2.6) and 24 other tissues See more Orthologs mouse all
CDKL2, Official Symbol CDKL2provided by HGNC Official Full Name cyclin dependent kinase like 2provided by HGNC Primary source HGNC:HGNC:1782 See related Ensembl:ENSG00000138769 MIM:603442; AllianceGenome:HGNC:1782 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P56; KKIAMRE Summary This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 7.0), brain (RPKM 3.3) and 6 other tissues See more Orthologs mouse all
CDKL3, Official Symbol CDKL3provided by HGNC Official Full Name cyclin dependent kinase like 3provided by HGNC Primary source HGNC:HGNC:15483 See related Ensembl:ENSG00000006837 MIM:608459; AllianceGenome:HGNC:15483 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NKIAMRE Summary The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 4.9), brain (RPKM 1.0) and 12 other tissues See more Orthologs mouse all
CDKL4, Official Symbol CDKL4provided by HGNC Official Full Name cyclin dependent kinase like 4provided by HGNC Primary source HGNC:HGNC:19287 See related Ensembl:ENSG00000205111 AllianceGenome:HGNC:19287 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
CDKL5, Official Symbol CDKL5provided by HGNC Official Full Name cyclin dependent kinase like 5provided by HGNC Primary source HGNC:HGNC:11411 See related Ensembl:ENSG00000008086 MIM:300203; AllianceGenome:HGNC:11411 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DEE2; ISSX; STK9; EIEE2; CFAP247 Summary This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] Expression Broad expression in brain (RPKM 11.1), lung (RPKM 3.0) and 18 other tissues See more Orthologs mouse all
CDKN1A, Official Symbol CDKN1Aprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 1Aprovided by HGNC Primary source HGNC:HGNC:1784 See related Ensembl:ENSG00000124762 MIM:116899; AllianceGenome:HGNC:1784 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 Summary This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in colon (RPKM 71.4), gall bladder (RPKM 68.8) and 24 other tissues See more Orthologs mouse all
CDKN1B, Official Symbol CDKN1Bprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 1Bprovided by HGNC Primary source HGNC:HGNC:1785 See related Ensembl:ENSG00000111276 MIM:600778; AllianceGenome:HGNC:1785 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIP1; MEN4; CDKN4; MEN1B; P27KIP1 Summary This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] Expression Ubiquitous expression in fat (RPKM 40.2), ovary (RPKM 35.6) and 25 other tissues See more Orthologs mouse all
CDKN1C, Official Symbol CDKN1Cprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 1Cprovided by HGNC Primary source HGNC:HGNC:1786 See related Ensembl:ENSG00000129757 MIM:600856; AllianceGenome:HGNC:1786 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BWS; WBS; p57; BWCR; KIP2; p57Kip2 Summary This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] Expression Biased expression in placenta (RPKM 87.0), fat (RPKM 42.6) and 9 other tissues See more Orthologs mouse all
CDKN2A, Official Symbol CDKN2Aprovided by HGNC Official Full Name cyclin dependent kinase inhibitor 2Aprovided by HGNC Primary source HGNC:HGNC:1787 See related Ensembl:ENSG00000147889 MIM:600160; AllianceGenome:HGNC:1787 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARF; MLM; P14; P16; P19; CAI2; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A Summary This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012] Expression Low expression observed in reference dataset See more Orthologs all
CDKN2AIP, Official Symbol CDKN2AIPprovided by HGNC Official Full Name CDKN2A interacting proteinprovided by HGNC Primary source HGNC:HGNC:24325 See related Ensembl:ENSG00000168564 MIM:615914; AllianceGenome:HGNC:24325 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CARF Summary The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in testis (RPKM 11.6), bone marrow (RPKM 11.5) and 25 other tissues See more Orthologs mouse all
CDKN2AIPNL, Official Symbol CDKN2AIPNLprovided by HGNC Official Full Name CDKN2A interacting protein N-terminal likeprovided by HGNC Primary source HGNC:HGNC:30545 See related Ensembl:ENSG00000237190 AllianceGenome:HGNC:30545 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2AIL Summary Predicted to be active in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 3.7) and 25 other tissues See more Orthologs mouse all
CDKN2AIPNLP3, Official Symbol CDKN2AIPNLP3provided by HGNC Official Full Name CDKN2A interacting protein N-terminal like pseudogene 3provided by HGNC Primary source HGNC:HGNC:39853 See related Ensembl:ENSG00000224351 AllianceGenome:HGNC:39853 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo