psui3905/ncbi_genes_summary huggingface dataset:
MEF2A, Official Symbol MEF2Aprovided by HGNC Official Full Name myocyte enhancer factor 2Aprovided by HGNC Primary source HGNC:HGNC:6993 See related Ensembl:ENSG00000068305 MIM:600660; AllianceGenome:HGNC:6993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as mef2; ADCAD1; RSRFC4; RSRFC9 Summary The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] Expression Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 12.2) and 25 other tissues See more Orthologs mouse all
MEF2B, Official Symbol MEF2Bprovided by HGNC Official Full Name myocyte enhancer factor 2Bprovided by HGNC Primary source HGNC:HGNC:6995 See related Ensembl:ENSG00000213999 MIM:600661; AllianceGenome:HGNC:6995 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RSRFR2 Summary The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014] Expression Broad expression in lymph node (RPKM 18.6), appendix (RPKM 7.2) and 17 other tissues See more Orthologs mouse all
MEF2C, Official Symbol MEF2Cprovided by HGNC Official Full Name myocyte enhancer factor 2Cprovided by HGNC Primary source HGNC:HGNC:6996 See related Ensembl:ENSG00000081189 MIM:600662; AllianceGenome:HGNC:6996 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEDHSIL; DEL5q14.3; C5DELq14.3 Summary This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] Expression Broad expression in brain (RPKM 55.2), lymph node (RPKM 17.7) and 19 other tissues See more Orthologs mouse all
MEF2C-AS1, Official Symbol MEF2C-AS1provided by HGNC Official Full Name MEF2C antisense RNA 1provided by HGNC Primary source HGNC:HGNC:48908 See related Ensembl:ENSG00000248309 AllianceGenome:HGNC:48908 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
MEF2C-AS2, Official Symbol MEF2C-AS2provided by HGNC Official Full Name MEF2C antisense RNA 2provided by HGNC Primary source HGNC:HGNC:53115 See related Ensembl:ENSG00000245864 AllianceGenome:HGNC:53115 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MEF2D, Official Symbol MEF2Dprovided by HGNC Official Full Name myocyte enhancer factor 2Dprovided by HGNC Primary source HGNC:HGNC:6997 See related Ensembl:ENSG00000116604 MIM:600663; AllianceGenome:HGNC:6997 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in bone marrow (RPKM 18.8), brain (RPKM 15.5) and 25 other tissues See more Orthologs mouse all
MEFV, Official Symbol MEFVprovided by HGNC Official Full Name MEFV innate immunity regulator, pyrinprovided by HGNC Primary source HGNC:HGNC:6998 See related Ensembl:ENSG00000103313 MIM:608107; AllianceGenome:HGNC:6998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FMF; MEF; PAAND; TRIM20 Summary This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008] Expression Biased expression in appendix (RPKM 3.9), spleen (RPKM 3.2) and 11 other tissues See more Orthologs mouse all
MEG3, Official Symbol MEG3provided by HGNC Official Full Name maternally expressed 3provided by HGNC Primary source HGNC:HGNC:14575 See related Ensembl:ENSG00000214548 MIM:605636; AllianceGenome:HGNC:14575 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GTL2; FP504; prebp1; PRO0518; PRO2160; LINC00023; NCRNA00023; onco-lncRNA-83 Summary This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012] Expression Biased expression in placenta (RPKM 89.5), adrenal (RPKM 54.9) and 6 other tissues See more Orthologs mouse all
MEG8, Official Symbol MEG8provided by HGNC Official Full Name maternally expressed 8, small nucleolar RNA host geneprovided by HGNC Primary source HGNC:HGNC:14574 See related MIM:613648; AllianceGenome:HGNC:14574 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Bsr; Irm; Rian; SNHG23; SNHG24; lnc-MGC; LINC00024; NCRNA00024 Summary This gene is located in a cluster of imprinted genes on chromosome 14q32.3. It encodes a a non-protein coding transcript that is preferentially expressed from the maternal allele in skeletal muscle, and appears to be coordinately regulated with other imprinted genes in this region. [provided by RefSeq, Oct 2010] Expression Biased expression in adrenal (RPKM 3.1), placenta (RPKM 2.2) and 6 other tissues See more
MEG9, Official Symbol MEG9provided by HGNC Official Full Name maternally expressed 9provided by HGNC Primary source HGNC:HGNC:43874 See related Ensembl:ENSG00000223403 AllianceGenome:HGNC:43874 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC00584 Expression Biased expression in placenta (RPKM 10.0), adrenal (RPKM 8.9) and 7 other tissues See more
MEGF10, Official Symbol MEGF10provided by HGNC Official Full Name multiple EGF like domains 10provided by HGNC Primary source HGNC:HGNC:29634 See related Ensembl:ENSG00000145794 MIM:612453; AllianceGenome:HGNC:29634 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SR-F3; EMARDD; CMYP10A; CMYP10B Summary This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012] Expression Biased expression in brain (RPKM 5.7), adrenal (RPKM 1.0) and 4 other tissues See more Orthologs mouse all
MEGF11, Official Symbol MEGF11provided by HGNC Official Full Name multiple EGF like domains 11provided by HGNC Primary source HGNC:HGNC:29635 See related Ensembl:ENSG00000157890 MIM:612454; AllianceGenome:HGNC:29635 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in brain (RPKM 3.0), testis (RPKM 0.5) and 2 other tissues See more Orthologs mouse all
MEGF6, Official Symbol MEGF6provided by HGNC Official Full Name multiple EGF like domains 6provided by HGNC Primary source HGNC:HGNC:3232 See related Ensembl:ENSG00000162591 MIM:604266; AllianceGenome:HGNC:3232 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EGFL3 Summary Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 15.1), lung (RPKM 6.0) and 20 other tissues See more Orthologs mouse all
MEGF8, Official Symbol MEGF8provided by HGNC Official Full Name multiple EGF like domains 8provided by HGNC Primary source HGNC:HGNC:3233 See related Ensembl:ENSG00000105429 MIM:604267; AllianceGenome:HGNC:3233 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SBP1; CRPT2; EGFL4; C19orf49 Summary The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] Expression Ubiquitous expression in brain (RPKM 10.9), fat (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
MEGF9, Official Symbol MEGF9provided by HGNC Official Full Name multiple EGF like domains 9provided by HGNC Primary source HGNC:HGNC:3234 See related Ensembl:ENSG00000106780 MIM:604268; AllianceGenome:HGNC:3234 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EGFL5 Summary Predicted to be involved in several processes, including animal organ morphogenesis; cell migration; and substrate adhesion-dependent cell spreading. Predicted to be integral component of membrane. Predicted to be active in basement membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 22.6), brain (RPKM 20.0) and 24 other tissues See more Orthologs mouse all
MEI1, Official Symbol MEI1provided by HGNC Official Full Name meiotic double-stranded break formation protein 1provided by HGNC Primary source HGNC:HGNC:28613 See related Ensembl:ENSG00000167077 MIM:608797; AllianceGenome:HGNC:28613 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYDM3; SPATA38 Summary Predicted to be involved in meiosis I. Predicted to act upstream of or within gamete generation; meiotic spindle organization; and meiotic telomere clustering. Implicated in gestational trophoblastic neoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 5.5), spleen (RPKM 2.0) and 13 other tissues See more Orthologs mouse all
MEI4, Official Symbol MEI4provided by HGNC Official Full Name meiotic double-stranded break formation protein 4provided by HGNC Primary source HGNC:HGNC:43638 See related Ensembl:ENSG00000269964 MIM:618417; AllianceGenome:HGNC:43638 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to be involved in gamete generation and meiosis I cell cycle process. Predicted to be active in lateral element. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in kidney (RPKM 2.5), testis (RPKM 1.9) and 6 other tissues See more Orthologs mouse all
MEIG1, Official Symbol MEIG1provided by HGNC Official Full Name meiosis/spermiogenesis associated 1provided by HGNC Primary source HGNC:HGNC:23429 See related Ensembl:ENSG00000197889 MIM:614174; AllianceGenome:HGNC:23429 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPATA39; bA2K17.3 Summary Predicted to act upstream of or within cellular protein localization; manchette assembly; and sperm axoneme assembly. Predicted to be located in cytosol and manchette. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 4.2) and brain (RPKM 0.2) See more Orthologs mouse all
MEIKIN, Official Symbol MEIKINprovided by HGNC Official Full Name meiotic kinetochore factorprovided by HGNC Primary source HGNC:HGNC:51253 See related Ensembl:ENSG00000239642 MIM:616232; AllianceGenome:HGNC:51253 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPO13 Summary Predicted to be involved in meiotic chromosome segregation. Predicted to be located in kinetochore. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 3.3) See more Orthologs mouse all
MEIOB, Official Symbol MEIOBprovided by HGNC Official Full Name meiosis specific with OB-foldprovided by HGNC Primary source HGNC:HGNC:28569 See related Ensembl:ENSG00000162039 MIM:617670; AllianceGenome:HGNC:28569 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as gs129; SPGF22; C16orf73 Summary Predicted to enable chromatin binding activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiotic nuclear division. Predicted to be located in cytoplasm. Implicated in spermatogenic failure 22. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 20.3) See more Orthologs mouse all
MEIOC, Official Symbol MEIOCprovided by HGNC Official Full Name meiosis specific with coiled-coil domainprovided by HGNC Primary source HGNC:HGNC:26670 See related Ensembl:ENSG00000180336 MIM:616934; AllianceGenome:HGNC:26670 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C17orf104 Summary Predicted to be involved in several processes, including gamete generation; germline cell cycle switching, mitotic to meiotic cell cycle; and mRNA stabilization. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 25.4) See more Orthologs mouse all
MEIOSIN, Official Symbol MEIOSINprovided by HGNC Official Full Name meiosis initiatorprovided by HGNC Primary source HGNC:HGNC:44318 See related Ensembl:ENSG00000237452 AllianceGenome:HGNC:44318 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BHMG1; HMGDC Summary Predicted to enable DNA binding activity and protein dimerization activity. Predicted to be involved in several processes, including activation of meiosis; cellular response to retinoic acid; and gamete generation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 3.0) See more Orthologs mouse all
MEIS1, Official Symbol MEIS1provided by HGNC Official Full Name Meis homeobox 1provided by HGNC Primary source HGNC:HGNC:7000 See related Ensembl:ENSG00000143995 MIM:601739; AllianceGenome:HGNC:7000 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 17.9), adrenal (RPKM 12.6) and 21 other tissues See more Orthologs mouse all
MEIS1-AS2, Official Symbol MEIS1-AS2provided by HGNC Official Full Name MEIS1 antisense RNA 2provided by HGNC Primary source HGNC:HGNC:40370 See related Ensembl:ENSG00000230749 AllianceGenome:HGNC:40370 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEIS1-AS1 Expression Broad expression in endometrium (RPKM 1.6), adrenal (RPKM 1.5) and 22 other tissues See more Orthologs mouse all
MEIS2, Official Symbol MEIS2provided by HGNC Official Full Name Meis homeobox 2provided by HGNC Primary source HGNC:HGNC:7001 See related Ensembl:ENSG00000134138 MIM:601740; AllianceGenome:HGNC:7001 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRG1; CPCMR; HsT18361 Summary This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 12.8), prostate (RPKM 12.0) and 24 other tissues See more Orthologs mouse all
MEIS3, Official Symbol MEIS3provided by HGNC Official Full Name Meis homeobox 3provided by HGNC Primary source HGNC:HGNC:29537 See related Ensembl:ENSG00000105419 MIM:619443; AllianceGenome:HGNC:29537 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRG2 Summary This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016] Expression Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues See more Orthologs mouse all
MELK, Official Symbol MELKprovided by HGNC Official Full Name maternal embryonic leucine zipper kinaseprovided by HGNC Primary source HGNC:HGNC:16870 See related Ensembl:ENSG00000165304 MIM:607025; AllianceGenome:HGNC:16870 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HPK38 Summary Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues See more Orthologs mouse all
MELTF, Official Symbol MELTFprovided by HGNC Official Full Name melanotransferrinprovided by HGNC Primary source HGNC:HGNC:7037 See related Ensembl:ENSG00000163975 MIM:155750; AllianceGenome:HGNC:7037 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MTf; MFI2; MTF1; CD228; MAP97 Summary The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008] Expression Broad expression in salivary gland (RPKM 9.5), kidney (RPKM 5.4) and 16 other tissues See more Orthologs mouse all
MELTF-AS1, Official Symbol MELTF-AS1provided by HGNC Official Full Name MELTF antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40373 See related Ensembl:ENSG00000228109 AllianceGenome:HGNC:40373 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PLANE; MFI2-AS1 Expression Broad expression in kidney (RPKM 7.2), testis (RPKM 6.9) and 24 other tissues See more
MEMO1, Official Symbol MEMO1provided by HGNC Official Full Name mediator of cell motility 1provided by HGNC Primary source HGNC:HGNC:14014 See related Ensembl:ENSG00000162959 MIM:611786; AllianceGenome:HGNC:14014 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEMO; C2orf4; CGI-27; NS5ATP7 Summary Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 22.5), bone marrow (RPKM 10.2) and 24 other tissues See more Orthologs mouse all
MEMO1P4, Official Symbol MEMO1P4provided by HGNC Official Full Name MEMO1 pseudogene 4provided by HGNC Primary source HGNC:HGNC:38504 See related Ensembl:ENSG00000230376 AllianceGenome:HGNC:38504 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MEMO1P5, Official Symbol MEMO1P5provided by HGNC Official Full Name MEMO1 pseudogene 5provided by HGNC Primary source HGNC:HGNC:49102 See related Ensembl:ENSG00000271492 AllianceGenome:HGNC:49102 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MEN1, Official Symbol MEN1provided by HGNC Official Full Name menin 1provided by HGNC Primary source HGNC:HGNC:7010 See related Ensembl:ENSG00000133895 MIM:613733; AllianceGenome:HGNC:7010 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEAI; SCG2 Summary This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019] Expression Ubiquitous expression in spleen (RPKM 7.6), lymph node (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
MEOX1, Official Symbol MEOX1provided by HGNC Official Full Name mesenchyme homeobox 1provided by HGNC Primary source HGNC:HGNC:7013 See related Ensembl:ENSG00000005102 MIM:600147; AllianceGenome:HGNC:7013 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KFS2; MOX1 Summary This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in fat (RPKM 15.6), heart (RPKM 8.2) and 11 other tissues See more Orthologs mouse all
MEOX2, Official Symbol MEOX2provided by HGNC Official Full Name mesenchyme homeobox 2provided by HGNC Primary source HGNC:HGNC:7014 See related Ensembl:ENSG00000106511 MIM:600535; AllianceGenome:HGNC:7014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GAX; MOX2 Summary This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008] Expression Biased expression in placenta (RPKM 25.8), fat (RPKM 23.2) and 13 other tissues See more Orthologs mouse all
MEP1A, Official Symbol MEP1Aprovided by HGNC Official Full Name meprin A subunit alphaprovided by HGNC Primary source HGNC:HGNC:7015 See related Ensembl:ENSG00000112818 MIM:600388; AllianceGenome:HGNC:7015 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPHA Summary Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. Part of meprin A complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 216.8), duodenum (RPKM 122.1) and 1 other tissue See more Orthologs mouse all
MEP1B, Official Symbol MEP1Bprovided by HGNC Official Full Name meprin A subunit betaprovided by HGNC Primary source HGNC:HGNC:7020 See related Ensembl:ENSG00000141434 MIM:600389; AllianceGenome:HGNC:7020 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011] Expression Biased expression in small intestine (RPKM 150.9) and duodenum (RPKM 98.0) See more Orthologs mouse all
MEPCE, Official Symbol MEPCEprovided by HGNC Official Full Name methylphosphate capping enzymeprovided by HGNC Primary source HGNC:HGNC:20247 See related Ensembl:ENSG00000146834 MIM:611478; AllianceGenome:HGNC:20247 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCDIN3 Summary Enables 7SK snRNA binding activity and RNA 5'-methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 29.4), spleen (RPKM 17.1) and 25 other tissues See more Orthologs mouse all
MEPE, Official Symbol MEPEprovided by HGNC Official Full Name matrix extracellular phosphoglycoproteinprovided by HGNC Primary source HGNC:HGNC:13361 See related Ensembl:ENSG00000152595 MIM:605912; AllianceGenome:HGNC:13361 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OF45 Summary This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] Expression Restricted expression toward brain (RPKM 2.2) See more Orthologs mouse all
MERTK, Official Symbol MERTKprovided by HGNC Official Full Name MER proto-oncogene, tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:7027 See related Ensembl:ENSG00000153208 MIM:604705; AllianceGenome:HGNC:7027 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MER; RP38; c-Eyk; c-mer; Tyro12 Summary This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] Expression Broad expression in adrenal (RPKM 25.0), spleen (RPKM 11.3) and 21 other tissues See more Orthologs mouse all
MESD, Official Symbol MESDprovided by HGNC Official Full Name mesoderm development LRP chaperoneprovided by HGNC Primary source HGNC:HGNC:13520 See related Ensembl:ENSG00000117899 MIM:607783; AllianceGenome:HGNC:13520 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BOCA; OI20; MESDC2 Summary Predicted to enable low-density lipoprotein particle receptor binding activity. Involved in ossification and protein folding. Located in endoplasmic reticulum. Implicated in osteogenesis imperfecta type 20. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 16.9), placenta (RPKM 10.6) and 25 other tissues See more Orthologs mouse all
MESP1, Official Symbol MESP1provided by HGNC Official Full Name mesoderm posterior bHLH transcription factor 1provided by HGNC Primary source HGNC:HGNC:29658 See related Ensembl:ENSG00000166823 MIM:608689; AllianceGenome:HGNC:29658 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bHLHc5 Summary Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including endothelial cell differentiation; heart development; and positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 4.6), prostate (RPKM 4.1) and 4 other tissues See more Orthologs mouse all
MESP2, Official Symbol MESP2provided by HGNC Official Full Name mesoderm posterior bHLH transcription factor 2provided by HGNC Primary source HGNC:HGNC:29659 See related Ensembl:ENSG00000188095 MIM:605195; AllianceGenome:HGNC:29659 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCDO2; bHLHc6 Summary This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
MEST, Official Symbol MESTprovided by HGNC Official Full Name mesoderm specific transcriptprovided by HGNC Primary source HGNC:HGNC:7028 See related Ensembl:ENSG00000106484 MIM:601029; AllianceGenome:HGNC:7028 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PEG1 Summary This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011] Expression Biased expression in placenta (RPKM 292.2), fat (RPKM 48.4) and 6 other tissues See more Orthologs mouse all
MESTIT1, Official Symbol MESTIT1provided by HGNC Official Full Name MEST intronic transcript 1, antisense RNAprovided by HGNC Primary source HGNC:HGNC:17991 See related Ensembl:ENSG00000272701 MIM:607794; AllianceGenome:HGNC:17991 Gene type ncRNA RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MEST-IT; PEG1-AS; MEST-AS1; MEST-IT1; NCRNA00040 Summary This gene encodes a non-protein coding antisense RNA that is imprinted, and preferentially expressed from the paternal allele. It is located in an intron of MEST gene in the opposite orientation, and shares the promoter region in common with one of the promoters (P2) of MEST gene. The antisense RNA is expressed predominantly in testis and mature motile spermatozoa, suggesting that it may be involved in the regulation of MEST expression during development.[provided by RefSeq, Oct 2010] Expression Biased expression in testis (RPKM 1.3), brain (RPKM 0.8) and 8 other tissues See more
MESTP1, Official Symbol MESTP1provided by HGNC Official Full Name mesoderm specific transcript pseudogene 1provided by HGNC Primary source HGNC:HGNC:29660 See related AllianceGenome:HGNC:29660 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MESTP3, Official Symbol MESTP3provided by HGNC Official Full Name mesoderm specific transcript pseudogene 3provided by HGNC Primary source HGNC:HGNC:38553 See related Ensembl:ENSG00000250927 AllianceGenome:HGNC:38553 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MESTP4, Official Symbol MESTP4provided by HGNC Official Full Name mesoderm specific transcript pseudogene 4provided by HGNC Primary source HGNC:HGNC:38554 See related AllianceGenome:HGNC:38554 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
MET, Official Symbol METprovided by HGNC Official Full Name MET proto-oncogene, receptor tyrosine kinaseprovided by HGNC Primary source HGNC:HGNC:7029 See related Ensembl:ENSG00000105976 MIM:164860; AllianceGenome:HGNC:7029 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97 Summary This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] Expression Broad expression in placenta (RPKM 12.8), liver (RPKM 11.3) and 20 other tissues See more Orthologs mouse all
METAP1, Official Symbol METAP1provided by HGNC Official Full Name methionyl aminopeptidase 1provided by HGNC Primary source HGNC:HGNC:15789 See related Ensembl:ENSG00000164024 MIM:610151; AllianceGenome:HGNC:15789 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAP1A; MetAP1A Summary Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Involved in platelet aggregation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in esophagus (RPKM 20.9), testis (RPKM 19.8) and 25 other tissues See more Orthologs mouse all
METAP1D, Official Symbol METAP1Dprovided by HGNC Official Full Name methionyl aminopeptidase type 1D, mitochondrialprovided by HGNC Primary source HGNC:HGNC:32583 See related Ensembl:ENSG00000172878 MIM:610267; AllianceGenome:HGNC:32583 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAP1D; MAP 1D; Metap1l; MetAP 1D Summary The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 2.3) and 25 other tissues See more Orthologs mouse all
METAP2, Official Symbol METAP2provided by HGNC Official Full Name methionyl aminopeptidase 2provided by HGNC Primary source HGNC:HGNC:16672 See related Ensembl:ENSG00000111142 MIM:601870; AllianceGenome:HGNC:16672 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MAP2; MNPEP; p67eIF2 Summary The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression Ubiquitous expression in testis (RPKM 26.5), lymph node (RPKM 23.7) and 25 other tissues See more Orthologs mouse all
METRN, Official Symbol METRNprovided by HGNC Official Full Name meteorin, glial cell differentiation regulatorprovided by HGNC Primary source HGNC:HGNC:14151 See related Ensembl:ENSG00000103260 MIM:610998; AllianceGenome:HGNC:14151 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C16orf23; c380A1.2 Summary Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008] Expression Broad expression in brain (RPKM 10.2), kidney (RPKM 4.0) and 23 other tissues See more Orthologs mouse all
METRNL, Official Symbol METRNLprovided by HGNC Official Full Name meteorin like, glial cell differentiation regulatorprovided by HGNC Primary source HGNC:HGNC:27584 See related Ensembl:ENSG00000176845 MIM:616241; AllianceGenome:HGNC:27584 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable hormone activity. Predicted to be involved in several processes, including brown fat cell differentiation; energy homeostasis; and positive regulation of brown fat cell differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in colon (RPKM 12.0), kidney (RPKM 11.4) and 25 other tissues See more Orthologs mouse all