psui3905/ncbi_genes_summary huggingface dataset:
SIAH2, Official Symbol SIAH2provided by HGNC Official Full Name siah E3 ubiquitin protein ligase 2provided by HGNC Primary source HGNC:HGNC:10858 See related Ensembl:ENSG00000181788 MIM:602213; AllianceGenome:HGNC:10858 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as hSiah2 Summary This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in adrenal (RPKM 42.6), placenta (RPKM 22.5) and 24 other tissues See more Orthologs mouse all
SIAH3, Official Symbol SIAH3provided by HGNC Official Full Name siah E3 ubiquitin protein ligase family member 3provided by HGNC Primary source HGNC:HGNC:30553 See related Ensembl:ENSG00000215475 MIM:615609; AllianceGenome:HGNC:30553 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in negative regulation of protein targeting to mitochondrion and regulation of protein stability. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
SIDT1, Official Symbol SIDT1provided by HGNC Official Full Name SID1 transmembrane family member 1provided by HGNC Primary source HGNC:HGNC:25967 See related Ensembl:ENSG00000072858 MIM:606816; AllianceGenome:HGNC:25967 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SID1; SID-1 Summary The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017] Expression Broad expression in lymph node (RPKM 4.1), brain (RPKM 3.6) and 19 other tissues See more Orthologs mouse all
SIDT1-AS1, Official Symbol SIDT1-AS1provided by HGNC Official Full Name SIDT1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41126 See related AllianceGenome:HGNC:41126 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
SIDT2, Official Symbol SIDT2provided by HGNC Official Full Name SID1 transmembrane family member 2provided by HGNC Primary source HGNC:HGNC:24272 See related Ensembl:ENSG00000149577 MIM:617551; AllianceGenome:HGNC:24272 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CGI-40 Summary Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and RNA transmembrane transporter activity. Involved in RNA transport. Located in lysosomal membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in stomach (RPKM 22.3), prostate (RPKM 21.9) and 25 other tissues See more Orthologs mouse all
SIGIRR, Official Symbol SIGIRRprovided by HGNC Official Full Name single Ig and TIR domain containingprovided by HGNC Primary source HGNC:HGNC:30575 See related Ensembl:ENSG00000185187 MIM:605478; AllianceGenome:HGNC:30575 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIR8; IL-1R8 Summary Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues See more Orthologs mouse all
SIGLEC1, Official Symbol SIGLEC1provided by HGNC Official Full Name sialic acid binding Ig like lectin 1provided by HGNC Primary source HGNC:HGNC:11127 See related Ensembl:ENSG00000088827 MIM:600751; AllianceGenome:HGNC:11127 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SN; CD169; SIGLEC-1 Summary This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Broad expression in placenta (RPKM 8.2), spleen (RPKM 6.4) and 20 other tissues See more Orthologs mouse all
SIGLEC10, Official Symbol SIGLEC10provided by HGNC Official Full Name sialic acid binding Ig like lectin 10provided by HGNC Primary source HGNC:HGNC:15620 See related Ensembl:ENSG00000142512 MIM:606091; AllianceGenome:HGNC:15620 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SLG2; PRO940; SIGLEC-10 Summary SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] Expression Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues See more Orthologs all
SIGLEC11, Official Symbol SIGLEC11provided by HGNC Official Full Name sialic acid binding Ig like lectin 11provided by HGNC Primary source HGNC:HGNC:15622 See related Ensembl:ENSG00000161640 MIM:607157; AllianceGenome:HGNC:15622 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Biased expression in ovary (RPKM 40.7), spleen (RPKM 13.8) and 1 other tissue See more Orthologs all
SIGLEC12, Official Symbol SIGLEC12provided by HGNC Official Full Name sialic acid binding Ig like lectin 12provided by HGNC Primary source HGNC:HGNC:15482 See related Ensembl:ENSG00000254521 MIM:606094; AllianceGenome:HGNC:15482 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as S2V; SLG; SIGLECL1; Siglec-XII Summary Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Biased expression in spleen (RPKM 5.4), appendix (RPKM 3.1) and 9 other tissues See more Orthologs all
SIGLEC14, Official Symbol SIGLEC14provided by HGNC Official Full Name sialic acid binding Ig like lectin 14provided by HGNC Primary source HGNC:HGNC:32926 See related Ensembl:ENSG00000254415 MIM:618132; AllianceGenome:HGNC:32926 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in ficolin-1-rich granule membrane and tertiary granule membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in spleen (RPKM 13.9), appendix (RPKM 9.2) and 7 other tissues See more Orthologs all
SIGLEC15, Official Symbol SIGLEC15provided by HGNC Official Full Name sialic acid binding Ig like lectin 15provided by HGNC Primary source HGNC:HGNC:27596 See related Ensembl:ENSG00000197046 MIM:618105; AllianceGenome:HGNC:27596 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD33L3; HsT1361; SIGLEC-15 Summary Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 1.8), duodenum (RPKM 1.0) and 8 other tissues See more Orthologs mouse all
SIGLEC16, Official Symbol SIGLEC16provided by HGNC Official Full Name sialic acid binding Ig like lectin 16provided by HGNC Primary source HGNC:HGNC:24851 See related Ensembl:ENSG00000161643 AllianceGenome:HGNC:24851 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIGLECP16; Siglec-P16 Summary Predicted to enable sialic acid binding activity. Involved in positive regulation of defense response to bacterium and positive regulation of interleukin-6 production. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Biased expression in ovary (RPKM 40.2) and spleen (RPKM 10.4) See more Orthologs all
SIGLEC18P, Official Symbol SIGLEC18Pprovided by HGNC Official Full Name sialic acid binding Ig like lectin 18, pseudogeneprovided by HGNC Primary source HGNC:HGNC:15491 See related AllianceGenome:HGNC:15491 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIGLECP1
SIGLEC21P, Official Symbol SIGLEC21Pprovided by HGNC Official Full Name sialic acid binding Ig like lectin 21, pseudogeneprovided by HGNC Primary source HGNC:HGNC:15610 See related AllianceGenome:HGNC:15610 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIGLECP5
SIGLEC26P, Official Symbol SIGLEC26Pprovided by HGNC Official Full Name sialic acid binding Ig like lectin 26, pseudogeneprovided by HGNC Primary source HGNC:HGNC:15615 See related AllianceGenome:HGNC:15615 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIGLECP10
SIGLEC28P, Official Symbol SIGLEC28Pprovided by HGNC Official Full Name sialic acid binding Ig like lectin 28, pseudogeneprovided by HGNC Primary source HGNC:HGNC:15618 See related AllianceGenome:HGNC:15618 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIGLECP12
SIGLEC29P, Official Symbol SIGLEC29Pprovided by HGNC Official Full Name sialic acid binding Ig like lectin 29, pseudogeneprovided by HGNC Primary source HGNC:HGNC:15619 See related AllianceGenome:HGNC:15619 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIGLECP13
SIGLEC6, Official Symbol SIGLEC6provided by HGNC Official Full Name sialic acid binding Ig like lectin 6provided by HGNC Primary source HGNC:HGNC:10875 See related Ensembl:ENSG00000105492 MIM:604405; AllianceGenome:HGNC:10875 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327 Summary This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016] Expression Biased expression in placenta (RPKM 50.1) and lung (RPKM 2.3) See more Orthologs all
SIGLEC7, Official Symbol SIGLEC7provided by HGNC Official Full Name sialic acid binding Ig like lectin 7provided by HGNC Primary source HGNC:HGNC:10876 See related Ensembl:ENSG00000168995 MIM:604410; AllianceGenome:HGNC:10876 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1 Summary Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 7.6), appendix (RPKM 5.3) and 14 other tissues See more Orthologs all
SIGLEC8, Official Symbol SIGLEC8provided by HGNC Official Full Name sialic acid binding Ig like lectin 8provided by HGNC Primary source HGNC:HGNC:10877 See related Ensembl:ENSG00000105366 MIM:605639; AllianceGenome:HGNC:10877 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SAF2; SIGLEC-8; SIGLEC8L Summary Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010] Expression Broad expression in lymph node (RPKM 2.6), spleen (RPKM 2.6) and 14 other tissues See more Orthologs all
SIGLEC9, Official Symbol SIGLEC9provided by HGNC Official Full Name sialic acid binding Ig like lectin 9provided by HGNC Primary source HGNC:HGNC:10878 See related Ensembl:ENSG00000129450 MIM:605640; AllianceGenome:HGNC:10878 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD329; CDw329; FOAP-9; siglec-9; OBBP-LIKE Summary Predicted to enable monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis, engulfment. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in appendix (RPKM 3.6), spleen (RPKM 2.9) and 15 other tissues See more Orthologs all
SIGLECL1, Official Symbol SIGLECL1provided by HGNC Official Full Name SIGLEC family like 1provided by HGNC Primary source HGNC:HGNC:26856 See related Ensembl:ENSG00000179213 AllianceGenome:HGNC:26856 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C19orf75; SIGLECP7; SIGLEC23P Summary Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 8.3) See more Orthologs mouse all
SIGMAR1, Official Symbol SIGMAR1provided by HGNC Official Full Name sigma non-opioid intracellular receptor 1provided by HGNC Primary source HGNC:HGNC:8157 See related Ensembl:ENSG00000147955 MIM:601978; AllianceGenome:HGNC:8157 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SRBP; ALS16; DSMA2; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R; hSigmaR1 Summary This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013] Expression Ubiquitous expression in liver (RPKM 44.6), duodenum (RPKM 22.5) and 25 other tissues See more Orthologs mouse all
SIK1, Official Symbol SIK1provided by HGNC Official Full Name salt inducible kinase 1provided by HGNC Primary source HGNC:HGNC:11142 See related Ensembl:ENSG00000142178 MIM:605705; AllianceGenome:HGNC:11142 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MSK; SIK; DEE30; SIK-1; SIK1B; SNF1LK Summary This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016] Expression Ubiquitous expression in adrenal (RPKM 28.1), liver (RPKM 25.6) and 25 other tissues See more Orthologs mouse all
SIK2, Official Symbol SIK2provided by HGNC Official Full Name salt inducible kinase 2provided by HGNC Primary source HGNC:HGNC:21680 See related Ensembl:ENSG00000170145 MIM:608973; AllianceGenome:HGNC:21680 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as QIK; SIK-2; SNF1LK2; LOH11CR1I Summary Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
SIK3, Official Symbol SIK3provided by HGNC Official Full Name SIK family kinase 3provided by HGNC Primary source HGNC:HGNC:29165 See related Ensembl:ENSG00000160584 MIM:614776; AllianceGenome:HGNC:29165 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L19; QSK; SEMDK; SIK-3 Summary Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 19.2), brain (RPKM 13.9) and 25 other tissues See more Orthologs mouse all
SIKE1, Official Symbol SIKE1provided by HGNC Official Full Name suppressor of IKBKE 1provided by HGNC Primary source HGNC:HGNC:26119 See related Ensembl:ENSG00000052723 MIM:611656; AllianceGenome:HGNC:26119 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIKE Summary SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in thyroid (RPKM 7.5), lymph node (RPKM 7.0) and 25 other tissues See more Orthologs mouse all
SIL1, Official Symbol SIL1provided by HGNC Official Full Name SIL1 nucleotide exchange factorprovided by HGNC Primary source HGNC:HGNC:24624 See related Ensembl:ENSG00000120725 MIM:608005; AllianceGenome:HGNC:24624 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BAP; MSS; ULG5 Summary This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 23.5), thyroid (RPKM 19.7) and 25 other tissues See more Orthologs mouse all
SILC1, Official Symbol SILC1provided by HGNC Official Full Name sciatic injury induced lincRNA upregulator of SOX11provided by HGNC Primary source HGNC:HGNC:26403 See related AllianceGenome:HGNC:26403 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LINC01105 Expression Restricted expression toward brain (RPKM 5.8) See more
SIM1, Official Symbol SIM1provided by HGNC Official Full Name SIM bHLH transcription factor 1provided by HGNC Primary source HGNC:HGNC:10882 See related Ensembl:ENSG00000112246 MIM:603128; AllianceGenome:HGNC:10882 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bHLHe14 Summary SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008] Expression Biased expression in kidney (RPKM 6.6) and fat (RPKM 0.4) See more Orthologs mouse all
SIM2, Official Symbol SIM2provided by HGNC Official Full Name SIM bHLH transcription factor 2provided by HGNC Primary source HGNC:HGNC:10883 See related Ensembl:ENSG00000159263 MIM:600892; AllianceGenome:HGNC:10883 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIM; bHLHe15; HMC13F06; HMC29C01 Summary This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] Expression Biased expression in kidney (RPKM 5.4), esophagus (RPKM 4.7) and 4 other tissues See more Orthologs mouse all
SIMC1, Official Symbol SIMC1provided by HGNC Official Full Name SUMO interacting motifs containing 1provided by HGNC Primary source HGNC:HGNC:24779 See related Ensembl:ENSG00000170085 MIM:618102; AllianceGenome:HGNC:24779 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OOMA1; PLEIAD; C5orf25 Summary Enables SUMO polymer binding activity and peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Located in sarcomere. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 8.3), ovary (RPKM 7.8) and 23 other tissues See more Orthologs mouse all
SIN3A, Official Symbol SIN3Aprovided by HGNC Official Full Name SIN3 transcription regulator family member Aprovided by HGNC Primary source HGNC:HGNC:19353 See related Ensembl:ENSG00000169375 MIM:607776; AllianceGenome:HGNC:19353 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as WITKOS; DEL15Q24; CHR15DELq24 Summary The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 15.9), thyroid (RPKM 12.9) and 25 other tissues See more Orthologs mouse all
SIN3B, Official Symbol SIN3Bprovided by HGNC Official Full Name SIN3 transcription regulator family member Bprovided by HGNC Primary source HGNC:HGNC:19354 See related Ensembl:ENSG00000127511 MIM:607777; AllianceGenome:HGNC:19354 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription by RNA polymerase II; and striated muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in testis (RPKM 19.2), endometrium (RPKM 17.1) and 25 other tissues See more Orthologs mouse all
SINHCAF, Official Symbol SINHCAFprovided by HGNC Official Full Name SIN3-HDAC complex associated factorprovided by HGNC Primary source HGNC:HGNC:30702 See related Ensembl:ENSG00000139146 MIM:615027; AllianceGenome:HGNC:30702 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as L4; TERA; FAM60A; C12orf14 Summary Involved in negative regulation of cell migration. Part of Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in endometrium (RPKM 24.9), lymph node (RPKM 18.1) and 25 other tissues See more Orthologs mouse all
SINHCAFP3, Official Symbol SINHCAFP3provided by HGNC Official Full Name SINHCAF pseudogene 3provided by HGNC Primary source HGNC:HGNC:19896 See related Ensembl:ENSG00000253488 AllianceGenome:HGNC:19896 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM60DP
SIPA1, Official Symbol SIPA1provided by HGNC Official Full Name signal-induced proliferation-associated 1provided by HGNC Primary source HGNC:HGNC:10885 See related Ensembl:ENSG00000213445 MIM:602180; AllianceGenome:HGNC:10885 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPA1 Summary The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 30.1), lymph node (RPKM 17.9) and 24 other tissues See more Orthologs mouse all
SIPA1L1, Official Symbol SIPA1L1provided by HGNC Official Full Name signal induced proliferation associated 1 like 1provided by HGNC Primary source HGNC:HGNC:20284 See related Ensembl:ENSG00000197555 MIM:617504; AllianceGenome:HGNC:20284 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as E6TP1; SPAR1 Summary Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; activation of GTPase activity; and regulation of postsynapse organization. Located in actin cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 7.9), spleen (RPKM 7.4) and 25 other tissues See more Orthologs mouse all
SIPA1L2, Official Symbol SIPA1L2provided by HGNC Official Full Name signal induced proliferation associated 1 like 2provided by HGNC Primary source HGNC:HGNC:23800 See related Ensembl:ENSG00000116991 MIM:611609; AllianceGenome:HGNC:23800 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPAL2; SPAR2 Summary This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015] Expression Ubiquitous expression in heart (RPKM 11.7), placenta (RPKM 10.4) and 24 other tissues See more Orthologs mouse all
SIPA1L3, Official Symbol SIPA1L3provided by HGNC Official Full Name signal induced proliferation associated 1 like 3provided by HGNC Primary source HGNC:HGNC:23801 See related Ensembl:ENSG00000105738 MIM:616655; AllianceGenome:HGNC:23801 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPAL3; SPAR3; CTRCT45 Summary This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in small intestine (RPKM 6.9), duodenum (RPKM 6.5) and 24 other tissues See more Orthologs mouse all
SIRLNT, Official Symbol SIRLNTprovided by HGNC Official Full Name SIRT1 regulating lncRNA tumor promoterprovided by HGNC Primary source HGNC:HGNC:53902 See related Ensembl:ENSG00000253802 AllianceGenome:HGNC:53902 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as lncRNA-PRLB
SIRPA, Official Symbol SIRPAprovided by HGNC Official Full Name signal regulatory protein alphaprovided by HGNC Primary source HGNC:HGNC:9662 See related Ensembl:ENSG00000198053 MIM:602461; AllianceGenome:HGNC:9662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1 Summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues See more Orthologs mouse all
SIRPB1, Official Symbol SIRPB1provided by HGNC Official Full Name signal regulatory protein beta 1provided by HGNC Primary source HGNC:HGNC:15928 See related Ensembl:ENSG00000101307 MIM:603889; AllianceGenome:HGNC:15928 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD172b; SIRP-BETA-1 Summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] Expression Broad expression in appendix (RPKM 6.6), bone marrow (RPKM 6.0) and 22 other tissues See more Orthologs all
SIRPB2, Official Symbol SIRPB2provided by HGNC Official Full Name signal regulatory protein beta 2provided by HGNC Primary source HGNC:HGNC:16247 See related Ensembl:ENSG00000196209 AllianceGenome:HGNC:16247 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTPN1L; PTPNS1L3; dJ776F14.2 Summary Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in appendix (RPKM 5.0), placenta (RPKM 2.4) and 14 other tissues See more Orthologs all
SIRPD, Official Symbol SIRPDprovided by HGNC Official Full Name signal regulatory protein deltaprovided by HGNC Primary source HGNC:HGNC:16248 See related Ensembl:ENSG00000125900 AllianceGenome:HGNC:16248 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTPNS1L2; dJ576H24.4 Summary Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward testis (RPKM 26.7) See more Orthologs all
SIRPG, Official Symbol SIRPGprovided by HGNC Official Full Name signal regulatory protein gammaprovided by HGNC Primary source HGNC:HGNC:15757 See related Ensembl:ENSG00000089012 MIM:605466; AllianceGenome:HGNC:15757 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma Summary The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 13.6), appendix (RPKM 6.0) and 8 other tissues See more Orthologs all
SIRPG-AS1, Official Symbol SIRPG-AS1provided by HGNC Official Full Name SIRPG antisense RNA 1provided by HGNC Primary source HGNC:HGNC:51229 See related Ensembl:ENSG00000237914 AllianceGenome:HGNC:51229 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
SIRT1, Official Symbol SIRT1provided by HGNC Official Full Name sirtuin 1provided by HGNC Primary source HGNC:HGNC:14929 See related Ensembl:ENSG00000096717 MIM:604479; AllianceGenome:HGNC:14929 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIR2; SIR2L1; SIR2alpha Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] Expression Ubiquitous expression in adrenal (RPKM 17.4), testis (RPKM 16.6) and 25 other tissues See more Orthologs mouse all
SIRT2, Official Symbol SIRT2provided by HGNC Official Full Name sirtuin 2provided by HGNC Primary source HGNC:HGNC:10886 See related Ensembl:ENSG00000068903 MIM:604480; AllianceGenome:HGNC:10886 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIR2; SIR2L; SIR2L2 Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues See more Orthologs mouse all
SIRT3, Official Symbol SIRT3provided by HGNC Official Full Name sirtuin 3provided by HGNC Primary source HGNC:HGNC:14931 See related Ensembl:ENSG00000142082 MIM:604481; AllianceGenome:HGNC:14931 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIR2L3 Summary SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019] Expression Ubiquitous expression in testis (RPKM 6.7), brain (RPKM 5.6) and 25 other tissues See more Orthologs mouse all
SIRT4, Official Symbol SIRT4provided by HGNC Official Full Name sirtuin 4provided by HGNC Primary source HGNC:HGNC:14932 See related Ensembl:ENSG00000089163 MIM:604482; AllianceGenome:HGNC:14932 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIR2L4 Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 2.4), kidney (RPKM 1.1) and 24 other tissues See more Orthologs mouse all