psui3905/ncbi_genes_summary huggingface dataset:
ILF3, Official Symbol ILF3provided by HGNC Official Full Name interleukin enhancer binding factor 3provided by HGNC Primary source HGNC:HGNC:6038 See related Ensembl:ENSG00000129351 MIM:603182; AllianceGenome:HGNC:6038 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NF90c; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; NFAR-2; NFAR90; TCP110; MPP4110; NF90ctv; NFAR110; MPHOSPH4; NF-AT-90 Summary This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014] Expression Ubiquitous expression in bone marrow (RPKM 45.0), testis (RPKM 34.6) and 25 other tissues See more Orthologs mouse all
ILF3-DT, Official Symbol ILF3-DTprovided by HGNC Official Full Name ILF3 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:27115 See related Ensembl:ENSG00000267100 AllianceGenome:HGNC:27115 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ILF3-AS1
ILK, Official Symbol ILKprovided by HGNC Official Full Name integrin linked kinaseprovided by HGNC Primary source HGNC:HGNC:6040 See related Ensembl:ENSG00000166333 MIM:602366; AllianceGenome:HGNC:6040 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P59; ILK-1; ILK-2; p59ILK; HEL-S-28 Summary This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Expression Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more Orthologs mouse all
ILKAP, Official Symbol ILKAPprovided by HGNC Official Full Name ILK associated serine/threonine phosphataseprovided by HGNC Primary source HGNC:HGNC:15566 See related Ensembl:ENSG00000132323 MIM:618909; AllianceGenome:HGNC:15566 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CD; PPM1O; ILKAP2; ILKAP3; PP2C-DELTA Summary The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 11.1), testis (RPKM 10.3) and 25 other tissues See more Orthologs mouse all
ILRUN, Official Symbol ILRUNprovided by HGNC Official Full Name inflammation and lipid regulator with UBA-like and NBR1-like domainsprovided by HGNC Primary source HGNC:HGNC:21215 See related Ensembl:ENSG00000196821 MIM:612217; AllianceGenome:HGNC:21215 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FP852; C6orf106; dJ391O22.4 Summary This gene encodes a protein with N-terminal ubiquitin-associated (UBA)-like and central neighbor of BRCA1 gene 1 (NBR1)-like domains. The protein acts an inhibitor of antiviral and proinflammatory cytokine transcription and as a regulator of the renin-angiotensin-aldosterone system (RAAS). [provided by RefSeq, Jul 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Ubiquitous expression in fat (RPKM 19.9), testis (RPKM 15.9) and 25 other tissues See more Orthologs mouse all
ILRUN-AS1, Official Symbol ILRUN-AS1provided by HGNC Official Full Name ILRUN antisense RNA 1provided by HGNC Primary source HGNC:HGNC:55216 See related Ensembl:ENSG00000272288 AllianceGenome:HGNC:55216 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in testis (RPKM 10.6), fat (RPKM 8.4) and 25 other tissues See more
ILVBL, Official Symbol ILVBLprovided by HGNC Official Full Name ilvB acetolactate synthase likeprovided by HGNC Primary source HGNC:HGNC:6041 See related Ensembl:ENSG00000105135 MIM:605770; AllianceGenome:HGNC:6041 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AHAS; 209L8; HACL2; ILV2H; HACL1L Summary The protein encoded by this gene shares similarity with several thiamine pyrophosphate-binding proteins identified in bacteria, yeast, and plants. The highest degree of similarity is found with bacterial acetolactate synthases (AHAS), which are enzymes that catalyze the first step in branched-chain amino acid biosynthesis. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 24.2), thyroid (RPKM 18.4) and 25 other tissues See more Orthologs mouse all
IMMP1L, Official Symbol IMMP1Lprovided by HGNC Official Full Name inner mitochondrial membrane peptidase subunit 1provided by HGNC Primary source HGNC:HGNC:26317 See related Ensembl:ENSG00000148950 MIM:612323; AllianceGenome:HGNC:26317 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMP1; IMMP1; IMP1-LIKE Summary The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008] Expression Ubiquitous expression in fat (RPKM 7.2), prostate (RPKM 6.9) and 25 other tissues See more Orthologs mouse all
IMMP1LP2, Official Symbol IMMP1LP2provided by HGNC Official Full Name inner mitochondrial membrane peptidase subunit 1 pseudogene 2provided by HGNC Primary source HGNC:HGNC:51132 See related AllianceGenome:HGNC:51132 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IMMP1LP3, Official Symbol IMMP1LP3provided by HGNC Official Full Name inner mitochondrial membrane peptidase subunit 1 pseudogene 3provided by HGNC Primary source HGNC:HGNC:51134 See related Ensembl:ENSG00000271098 AllianceGenome:HGNC:51134 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IMMP2L, Official Symbol IMMP2Lprovided by HGNC Official Full Name inner mitochondrial membrane peptidase subunit 2provided by HGNC Primary source HGNC:HGNC:14598 See related Ensembl:ENSG00000184903 MIM:605977; AllianceGenome:HGNC:14598 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMP2; IMP2-LIKE; IMMP2L-IT1 Summary This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
IMMT, Official Symbol IMMTprovided by HGNC Official Full Name inner membrane mitochondrial proteinprovided by HGNC Primary source HGNC:HGNC:6047 See related Ensembl:ENSG00000132305 MIM:600378; AllianceGenome:HGNC:6047 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HMP; P87; P89; PIG4; Mic60; PIG52; MINOS2; P87/89; MICOS60 Summary Enables RNA binding activity. Involved in cristae formation. Located in mitochondrial inner membrane. Part of MICOS complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in heart (RPKM 51.0), adrenal (RPKM 34.2) and 25 other tissues See more Orthologs mouse all
IMMTP1, Official Symbol IMMTP1provided by HGNC Official Full Name inner membrane mitochondrial protein pseudogene 1provided by HGNC Primary source HGNC:HGNC:6048 See related Ensembl:ENSG00000229880 AllianceGenome:HGNC:6048 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMMTP
IMP3, Official Symbol IMP3provided by HGNC Official Full Name IMP U3 small nucleolar ribonucleoprotein 3provided by HGNC Primary source HGNC:HGNC:14497 See related Ensembl:ENSG00000177971 MIM:612980; AllianceGenome:HGNC:14497 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BRMS2; MRPS4; C15orf12 Summary This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008] Annotation information Note: IMP3 (Gene ID: 55272) and IGF2BP3 (Gene ID: 10643) share the IMP3 symbol/alias in common. IMP3 is a widely used alternative name for insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), which can be confused with the official symbol for IMP3, U3 small nucleolar ribonucleoprotein (IMP3). [17 May 2018] Orthologs mouse all
IMP3P1, Official Symbol IMP3P1provided by HGNC Official Full Name IMP3 pseudogene 1provided by HGNC Primary source HGNC:HGNC:49385 See related Ensembl:ENSG00000230589 AllianceGenome:HGNC:49385 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IMP3P2, Official Symbol IMP3P2provided by HGNC Official Full Name IMP3 pseudogene 2provided by HGNC Primary source HGNC:HGNC:49386 See related Ensembl:ENSG00000239722 AllianceGenome:HGNC:49386 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IMP4, Official Symbol IMP4provided by HGNC Official Full Name IMP U3 small nucleolar ribonucleoprotein 4provided by HGNC Primary source HGNC:HGNC:30856 See related Ensembl:ENSG00000136718 MIM:612981; AllianceGenome:HGNC:30856 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BXDC4 Summary The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues See more Orthologs mouse all
IMPA1, Official Symbol IMPA1provided by HGNC Official Full Name inositol monophosphatase 1provided by HGNC Primary source HGNC:HGNC:6050 See related Ensembl:ENSG00000133731 MIM:602064; AllianceGenome:HGNC:6050 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMP; IMPA; MRT59 Summary This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014] Expression Ubiquitous expression in testis (RPKM 15.5), thyroid (RPKM 10.4) and 24 other tissues See more Orthologs mouse all
IMPA2, Official Symbol IMPA2provided by HGNC Official Full Name inositol monophosphatase 2provided by HGNC Primary source HGNC:HGNC:6051 See related Ensembl:ENSG00000141401 MIM:605922; AllianceGenome:HGNC:6051 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011] Expression Broad expression in kidney (RPKM 73.3), skin (RPKM 38.8) and 18 other tissues See more Orthologs mouse all
IMPACT, Official Symbol IMPACTprovided by HGNC Official Full Name impact RWD domain proteinprovided by HGNC Primary source HGNC:HGNC:20387 See related Ensembl:ENSG00000154059 MIM:615319; AllianceGenome:HGNC:20387 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RWDD5 Summary Predicted to enable actin binding activity and ribosome binding activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to starvation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in cytoplasm. Predicted to be part of polysome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 17.1), testis (RPKM 17.0) and 25 other tissues See more Orthologs mouse all
IMPDH1, Official Symbol IMPDH1provided by HGNC Official Full Name inosine monophosphate dehydrogenase 1provided by HGNC Primary source HGNC:HGNC:6052 See related Ensembl:ENSG00000106348 MIM:146690; AllianceGenome:HGNC:6052 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMPD; RP10; IMPD1; LCA11; IMPDH-I; sWSS2608 Summary The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] Expression Ubiquitous expression in fat (RPKM 19.1), appendix (RPKM 15.8) and 24 other tissues See more Orthologs mouse all
IMPDH1P10, Official Symbol IMPDH1P10provided by HGNC Official Full Name inosine monophosphate dehydrogenase 1 pseudogene 10provided by HGNC Primary source HGNC:HGNC:33965 See related Ensembl:ENSG00000232133 AllianceGenome:HGNC:33965 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IMPDH1P6, Official Symbol IMPDH1P6provided by HGNC Official Full Name inosine monophosphate dehydrogenase 1 pseudogene 6provided by HGNC Primary source HGNC:HGNC:33961 See related AllianceGenome:HGNC:33961 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IMPDH1P7, Official Symbol IMPDH1P7provided by HGNC Official Full Name inosine monophosphate dehydrogenase 1 pseudogene 7provided by HGNC Primary source HGNC:HGNC:33962 See related AllianceGenome:HGNC:33962 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IMPDH2, Official Symbol IMPDH2provided by HGNC Official Full Name inosine monophosphate dehydrogenase 2provided by HGNC Primary source HGNC:HGNC:6053 See related Ensembl:ENSG00000178035 MIM:146691; AllianceGenome:HGNC:6053 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IMPD2; IMPDH-II Summary This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 136.8), skin (RPKM 49.4) and 25 other tissues See more Orthologs mouse all
IMPG1, Official Symbol IMPG1provided by HGNC Official Full Name interphotoreceptor matrix proteoglycan 1provided by HGNC Primary source HGNC:HGNC:6055 See related Ensembl:ENSG00000112706 MIM:602870; AllianceGenome:HGNC:6055 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP91; VMD4; GP147; SPACR; IPM150 Summary This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all
IMPG2, Official Symbol IMPG2provided by HGNC Official Full Name interphotoreceptor matrix proteoglycan 2provided by HGNC Primary source HGNC:HGNC:18362 See related Ensembl:ENSG00000081148 MIM:607056; AllianceGenome:HGNC:18362 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RP56; VMD5; IPM200; SPACRCAN Summary The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011] Expression Low expression observed in reference dataset See more Orthologs mouse all
INA, Official Symbol INAprovided by HGNC Official Full Name internexin neuronal intermediate filament protein alphaprovided by HGNC Primary source HGNC:HGNC:6057 See related Ensembl:ENSG00000148798 MIM:605338; AllianceGenome:HGNC:6057 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NEF5; NF66; NF-66; TXBP-1 Summary Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009] Expression Biased expression in brain (RPKM 37.1) and adrenal (RPKM 7.8) See more Orthologs mouse all
INAFM1, Official Symbol INAFM1provided by HGNC Official Full Name InaF motif containing 1provided by HGNC Primary source HGNC:HGNC:27406 See related Ensembl:ENSG00000257704 AllianceGenome:HGNC:27406 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PRR24 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in adrenal (RPKM 12.5), endometrium (RPKM 9.8) and 25 other tissues See more Orthologs mouse all
INAFM2, Official Symbol INAFM2provided by HGNC Official Full Name InaF motif containing 2provided by HGNC Primary source HGNC:HGNC:35165 See related Ensembl:ENSG00000259330 AllianceGenome:HGNC:35165 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OGU1; LINC00984 Summary Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 12.3), brain (RPKM 7.7) and 25 other tissues See more Orthologs mouse all
INAVA, Official Symbol INAVAprovided by HGNC Official Full Name innate immunity activatorprovided by HGNC Primary source HGNC:HGNC:25599 See related Ensembl:ENSG00000163362 MIM:618051; AllianceGenome:HGNC:25599 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1orf106 Summary Involved in several processes, including nucleotide-binding activity oligomerization domain containing 2 signaling pathway; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in cytoplasm and nucleus. Implicated in inflammatory bowel disease 29. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in small intestine (RPKM 20.8), duodenum (RPKM 17.6) and 11 other tissues See more Orthologs mouse all
INCA1, Official Symbol INCA1provided by HGNC Official Full Name inhibitor of CDK, cyclin A1 interacting protein 1provided by HGNC Primary source HGNC:HGNC:32224 See related Ensembl:ENSG00000196388 MIM:617374; AllianceGenome:HGNC:32224 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HSD45 Summary Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 10.5), prostate (RPKM 1.7) and 21 other tissues See more Orthologs mouse all
INCENP, Official Symbol INCENPprovided by HGNC Official Full Name inner centromere proteinprovided by HGNC Primary source HGNC:HGNC:6058 See related Ensembl:ENSG00000149503 MIM:604411; AllianceGenome:HGNC:6058 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in bone marrow (RPKM 6.2), esophagus (RPKM 5.2) and 24 other tissues See more Orthologs mouse all
INE1, Official Symbol INE1provided by HGNC Official Full Name inactivation escape 1provided by HGNC Primary source HGNC:HGNC:6060 See related Ensembl:ENSG00000224975 MIM:300164; AllianceGenome:HGNC:6060 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCRNA00010 Summary X chromosome inactivation provides dosage compensation for the expression level of X-linked genes from the single X in males and the two in females. This X chromosome gene is intronless and was identified because its transcription escapes X inactivation in females. This gene does not make a protein.[provided by RefSeq, May 2010]
INE2, Official Symbol INE2provided by HGNC Official Full Name inactivation escape 2provided by HGNC Primary source HGNC:HGNC:6061 See related Ensembl:ENSG00000281371 MIM:300165; AllianceGenome:HGNC:6061 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NCRNA00011
INF2, Official Symbol INF2provided by HGNC Official Full Name inverted formin 2provided by HGNC Primary source HGNC:HGNC:23791 See related Ensembl:ENSG00000203485 MIM:610982; AllianceGenome:HGNC:23791 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FSGS5; CMTDIE; pp9484; C14orf151; C14orf173 Summary This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010] Expression Ubiquitous expression in fat (RPKM 22.3), stomach (RPKM 20.4) and 25 other tissues See more Orthologs mouse all
ING1, Official Symbol ING1provided by HGNC Official Full Name inhibitor of growth family member 1provided by HGNC Primary source HGNC:HGNC:6062 See related Ensembl:ENSG00000153487 MIM:601566; AllianceGenome:HGNC:6062 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a Summary This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 5.0), endometrium (RPKM 4.3) and 25 other tissues See more Orthologs mouse all
ING2, Official Symbol ING2provided by HGNC Official Full Name inhibitor of growth family member 2provided by HGNC Primary source HGNC:HGNC:6063 See related Ensembl:ENSG00000168556 MIM:604215; AllianceGenome:HGNC:6063 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ING1L; p33ING2 Summary This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Expression Ubiquitous expression in ovary (RPKM 10.5), adrenal (RPKM 8.4) and 25 other tissues See more Orthologs mouse all
ING3, Official Symbol ING3provided by HGNC Official Full Name inhibitor of growth family member 3provided by HGNC Primary source HGNC:HGNC:14587 See related Ensembl:ENSG00000071243 MIM:607493; AllianceGenome:HGNC:14587 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Eaf4; ING2; MEAF4; p47ING3 Summary The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 18.3), lymph node (RPKM 6.0) and 24 other tissues See more Orthologs mouse all
ING4, Official Symbol ING4provided by HGNC Official Full Name inhibitor of growth family member 4provided by HGNC Primary source HGNC:HGNC:19423 See related Ensembl:ENSG00000111653 MIM:608524; AllianceGenome:HGNC:19423 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as my036; p29ING4 Summary This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 15.7), endometrium (RPKM 14.9) and 25 other tissues See more Orthologs mouse all
ING5, Official Symbol ING5provided by HGNC Official Full Name inhibitor of growth family member 5provided by HGNC Primary source HGNC:HGNC:19421 See related Ensembl:ENSG00000168395 MIM:608525; AllianceGenome:HGNC:19421 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p28ING5 Summary This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016] Expression Ubiquitous expression in ovary (RPKM 3.6), skin (RPKM 3.2) and 25 other tissues See more Orthologs mouse all
INGX, Official Symbol INGXprovided by HGNC Official Full Name inhibitor of growth family, X-linked (pseudogene)provided by HGNC Primary source HGNC:HGNC:6064 See related Ensembl:ENSG00000243468 MIM:300452; AllianceGenome:HGNC:6064 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ING2; ING1-like
INHA, Official Symbol INHAprovided by HGNC Official Full Name inhibin subunit alphaprovided by HGNC Primary source HGNC:HGNC:6065 See related Ensembl:ENSG00000123999 MIM:147380; AllianceGenome:HGNC:6065 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016] Expression Biased expression in testis (RPKM 55.0), adrenal (RPKM 22.2) and 2 other tissues See more Orthologs mouse all
INHBA, Official Symbol INHBAprovided by HGNC Official Full Name inhibin subunit beta Aprovided by HGNC Primary source HGNC:HGNC:6066 See related Ensembl:ENSG00000122641 MIM:147290; AllianceGenome:HGNC:6066 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EDF; FRP Summary This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016] Expression Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues See more Orthologs mouse all
INHBA-AS1, Official Symbol INHBA-AS1provided by HGNC Official Full Name INHBA antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40303 See related Ensembl:ENSG00000224116 AllianceGenome:HGNC:40303 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
INHBB, Official Symbol INHBBprovided by HGNC Official Full Name inhibin subunit beta Bprovided by HGNC Primary source HGNC:HGNC:6067 See related Ensembl:ENSG00000163083 MIM:147390; AllianceGenome:HGNC:6067 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016] Expression Biased expression in fat (RPKM 16.6), testis (RPKM 13.1) and 13 other tissues See more Orthologs mouse all
INHBC, Official Symbol INHBCprovided by HGNC Official Full Name inhibin subunit beta Cprovided by HGNC Primary source HGNC:HGNC:6068 See related Ensembl:ENSG00000175189 MIM:601233; AllianceGenome:HGNC:6068 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IHBC Summary This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016] Expression Restricted expression toward liver (RPKM 50.2) See more Orthologs mouse all
INHBE, Official Symbol INHBEprovided by HGNC Official Full Name inhibin subunit beta Eprovided by HGNC Primary source HGNC:HGNC:24029 See related Ensembl:ENSG00000139269 MIM:612031; AllianceGenome:HGNC:24029 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016] Expression Restricted expression toward liver (RPKM 43.7) See more Orthologs mouse all
INHCAP, Official Symbol INHCAPprovided by HGNC Official Full Name inhibitor of carbonic anhydrase pseudogeneprovided by HGNC Primary source HGNC:HGNC:11759 See related AllianceGenome:HGNC:11759 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TFP; TFP1 Orthologs all
INIP, Official Symbol INIPprovided by HGNC Official Full Name INTS3 and NABP interacting proteinprovided by HGNC Primary source HGNC:HGNC:24994 See related Ensembl:ENSG00000148153 MIM:613273; AllianceGenome:HGNC:24994 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MISE; SOSSC; SSBIP1; C9orf80; HSPC043; hSSBIP1 Summary The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016] Expression Ubiquitous expression in lymph node (RPKM 8.2), colon (RPKM 6.8) and 25 other tissues See more Orthologs mouse all
INKA1, Official Symbol INKA1provided by HGNC Official Full Name inka box actin regulator 1provided by HGNC Primary source HGNC:HGNC:32480 See related Ensembl:ENSG00000185614 MIM:620426; AllianceGenome:HGNC:32480 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as INCA; C3orf54; FAM212A Summary Enables protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity. Predicted to act upstream of or within neural tube development. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 6.6), lung (RPKM 3.2) and 23 other tissues See more Orthologs mouse all
INKA2, Official Symbol INKA2provided by HGNC Official Full Name inka box actin regulator 2provided by HGNC Primary source HGNC:HGNC:28045 See related Ensembl:ENSG00000197852 MIM:620403; AllianceGenome:HGNC:28045 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM212B; C1orf183 Summary Enables protein kinase binding activity. Predicted to be involved in negative regulation of catalytic activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 3.4) and 23 other tissues See more Orthologs mouse all
INKA2-AS1, Official Symbol INKA2-AS1provided by HGNC Official Full Name INKA2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:49446 See related Ensembl:ENSG00000227811 AllianceGenome:HGNC:49446 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAM212B-AS1 Expression Broad expression in placenta (RPKM 1.6), brain (RPKM 0.9) and 16 other tissues See more
INMT, Official Symbol INMTprovided by HGNC Official Full Name indolethylamine N-methyltransferaseprovided by HGNC Primary source HGNC:HGNC:6069 See related Ensembl:ENSG00000241644 MIM:604854; AllianceGenome:HGNC:6069 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEMT Summary N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019] Expression Broad expression in lung (RPKM 67.4), adrenal (RPKM 18.7) and 14 other tissues See more Orthologs mouse all