psui3905/ncbi_genes_summary huggingface dataset:
PPP1R12B, Official Symbol PPP1R12Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 12Bprovided by HGNC Primary source HGNC:HGNC:7619 See related Ensembl:ENSG00000077157 MIM:603768; AllianceGenome:HGNC:7619 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYPT2; PP1bp55 Summary Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011] Expression Broad expression in heart (RPKM 45.5), endometrium (RPKM 24.6) and 17 other tissues See more Orthologs mouse all
PPP1R12BP1, Official Symbol PPP1R12BP1provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 12B pseudogene 1provided by HGNC Primary source HGNC:HGNC:18498 See related Ensembl:ENSG00000229238 AllianceGenome:HGNC:18498 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPP1R12BP; PPP1R12BPY1
PPP1R12BP2, Official Symbol PPP1R12BP2provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 12B pseudogene 2provided by HGNC Primary source HGNC:HGNC:23970 See related Ensembl:ENSG00000205936 AllianceGenome:HGNC:23970 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPP1R12C, Official Symbol PPP1R12Cprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 12Cprovided by HGNC Primary source HGNC:HGNC:14947 See related Ensembl:ENSG00000125503 MIM:613245; AllianceGenome:HGNC:14947 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p84; p85; AAVS1; LENG3; MBS85 Summary The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] Expression Ubiquitous expression in testis (RPKM 32.8), endometrium (RPKM 32.5) and 25 other tissues See more Orthologs mouse all
PPP1R13B, Official Symbol PPP1R13Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 13Bprovided by HGNC Primary source HGNC:HGNC:14950 See related Ensembl:ENSG00000088808 MIM:606455; AllianceGenome:HGNC:14950 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p85; ASPP1; p53BP2-like Summary This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008] Expression Broad expression in thyroid (RPKM 17.5), testis (RPKM 15.0) and 24 other tissues See more Orthologs mouse all
PPP1R13L, Official Symbol PPP1R13Lprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 13 likeprovided by HGNC Primary source HGNC:HGNC:18838 See related Ensembl:ENSG00000104881 MIM:607463; AllianceGenome:HGNC:18838 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as RAI; RAI4; IASPP; NKIP1 Summary IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] Expression Broad expression in skin (RPKM 27.0), placenta (RPKM 6.4) and 14 other tissues See more Orthologs mouse all
PPP1R14A, Official Symbol PPP1R14Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 14Aprovided by HGNC Primary source HGNC:HGNC:14871 See related Ensembl:ENSG00000167641 MIM:608153; AllianceGenome:HGNC:14871 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPI17; CPI-17; PPP1INL Summary The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011] Expression Broad expression in fat (RPKM 20.4), spleen (RPKM 15.6) and 20 other tissues See more Orthologs mouse all
PPP1R14B, Official Symbol PPP1R14Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 14Bprovided by HGNC Primary source HGNC:HGNC:9057 See related Ensembl:ENSG00000173457 MIM:601140; AllianceGenome:HGNC:9057 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PNG; PHI-1; PLCB3N; SOM172 Summary Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in skin (RPKM 28.9), appendix (RPKM 28.1) and 25 other tissues See more Orthologs mouse all
PPP1R14B-AS1, Official Symbol PPP1R14B-AS1provided by HGNC Official Full Name PPP1R14B antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54233 See related Ensembl:ENSG00000256940 AllianceGenome:HGNC:54233 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 7.9), duodenum (RPKM 3.8) and 18 other tissues See more
PPP1R14C, Official Symbol PPP1R14Cprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 14Cprovided by HGNC Primary source HGNC:HGNC:14952 See related Ensembl:ENSG00000198729 MIM:613242; AllianceGenome:HGNC:14952 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KEPI; NY-BR-81; CPI17-like Summary The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010] Expression Biased expression in thyroid (RPKM 22.2), heart (RPKM 17.2) and 9 other tissues See more Orthologs mouse all
PPP1R14D, Official Symbol PPP1R14Dprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 14Dprovided by HGNC Primary source HGNC:HGNC:14953 See related Ensembl:ENSG00000166143 MIM:613256; AllianceGenome:HGNC:14953 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GBPI1; GBPI-1; CPI17-like Summary Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010] Expression Biased expression in duodenum (RPKM 31.1), colon (RPKM 28.0) and 3 other tissues See more Orthologs mouse all
PPP1R15A, Official Symbol PPP1R15Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 15Aprovided by HGNC Primary source HGNC:HGNC:14375 See related Ensembl:ENSG00000087074 MIM:611048; AllianceGenome:HGNC:14375 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GADD34 Summary This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 214.4), gall bladder (RPKM 51.1) and 23 other tissues See more Orthologs mouse all
PPP1R15B, Official Symbol PPP1R15Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 15Bprovided by HGNC Primary source HGNC:HGNC:14951 See related Ensembl:ENSG00000158615 MIM:613257; AllianceGenome:HGNC:14951 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CREP; MSSGM2 Summary This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016] Expression Ubiquitous expression in bone marrow (RPKM 43.3), gall bladder (RPKM 18.5) and 25 other tissues See more Orthologs mouse all
PPP1R16A, Official Symbol PPP1R16Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 16Aprovided by HGNC Primary source HGNC:HGNC:14941 See related Ensembl:ENSG00000160972 MIM:609172; AllianceGenome:HGNC:14941 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MYPT3 Summary Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020] Expression Broad expression in duodenum (RPKM 18.4), small intestine (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
PPP1R16B, Official Symbol PPP1R16Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 16Bprovided by HGNC Primary source HGNC:HGNC:15850 See related Ensembl:ENSG00000101445 MIM:613275; AllianceGenome:HGNC:15850 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIMAP; ANKRD4 Summary The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015] Expression Broad expression in lymph node (RPKM 19.5), brain (RPKM 18.4) and 18 other tissues See more Orthologs mouse all
PPP1R17, Official Symbol PPP1R17provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 17provided by HGNC Primary source HGNC:HGNC:16973 See related Ensembl:ENSG00000106341 MIM:604088; AllianceGenome:HGNC:16973 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GSBS; C7orf16 Summary The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] Expression Biased expression in adrenal (RPKM 1.4), brain (RPKM 0.7) and 3 other tissues See more Orthologs mouse all
PPP1R18, Official Symbol PPP1R18provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 18provided by HGNC Primary source HGNC:HGNC:29413 See related Ensembl:ENSG00000146112 MIM:610990; AllianceGenome:HGNC:29413 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HKMT1098; KIAA1949 Summary Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008] Expression Broad expression in lymph node (RPKM 31.8), appendix (RPKM 27.5) and 24 other tissues See more Orthologs mouse all
PPP1R1A, Official Symbol PPP1R1Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 1Aprovided by HGNC Primary source HGNC:HGNC:9286 See related Ensembl:ENSG00000135447 MIM:613246; AllianceGenome:HGNC:9286 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as I1; IPP1 Summary Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in fat (RPKM 174.0), kidney (RPKM 33.7) and 3 other tissues See more Orthologs mouse all
PPP1R1AP1, Official Symbol PPP1R1AP1provided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 1A pseudogene 1provided by HGNC Primary source HGNC:HGNC:16316 See related Ensembl:ENSG00000255255 AllianceGenome:HGNC:16316 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPP1R1B, Official Symbol PPP1R1Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 1Bprovided by HGNC Primary source HGNC:HGNC:9287 See related Ensembl:ENSG00000131771 MIM:604399; AllianceGenome:HGNC:9287 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DARPP32; DARPP-32 Summary This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Expression Biased expression in colon (RPKM 51.4), salivary gland (RPKM 45.0) and 11 other tissues See more Orthologs mouse all
PPP1R1C, Official Symbol PPP1R1Cprovided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 1Cprovided by HGNC Primary source HGNC:HGNC:14940 See related Ensembl:ENSG00000150722 MIM:613240; AllianceGenome:HGNC:14940 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPP5 Summary Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010] Expression Biased expression in heart (RPKM 4.6), testis (RPKM 4.4) and 5 other tissues See more Orthologs mouse all
PPP1R2, Official Symbol PPP1R2provided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 2provided by HGNC Primary source HGNC:HGNC:9288 See related Ensembl:ENSG00000184203 MIM:601792; AllianceGenome:HGNC:9288 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPP2; IPP-2; PPP1R2A Summary Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] Expression Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues See more Orthologs mouse all
PPP1R21, Official Symbol PPP1R21provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 21provided by HGNC Primary source HGNC:HGNC:30595 See related Ensembl:ENSG00000162869 MIM:618159; AllianceGenome:HGNC:30595 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KLRAQ1; CCDC128; NEDHFBA Summary Located in early endosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 15.5), kidney (RPKM 15.1) and 25 other tissues See more Orthologs mouse all
PPP1R26, Official Symbol PPP1R26provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 26provided by HGNC Primary source HGNC:HGNC:29089 See related Ensembl:ENSG00000196422 MIM:614056; AllianceGenome:HGNC:29089 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRBE3; KIAA0649 Summary Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in brain (RPKM 4.1), kidney (RPKM 3.8) and 24 other tissues See more Orthologs mouse all
PPP1R26-AS1, Official Symbol PPP1R26-AS1provided by HGNC Official Full Name PPP1R26 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:48717 See related Ensembl:ENSG00000225361 AllianceGenome:HGNC:48717 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in prostate (RPKM 1.1), testis (RPKM 1.0) and 24 other tissues See more
PPP1R26P1, Official Symbol PPP1R26P1provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 26 pseudogene 1provided by HGNC Primary source HGNC:HGNC:42015 See related Ensembl:ENSG00000238086 AllianceGenome:HGNC:42015 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA0649P1
PPP1R26P2, Official Symbol PPP1R26P2provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 26 pseudogene 2provided by HGNC Primary source HGNC:HGNC:42016 See related Ensembl:ENSG00000273643 AllianceGenome:HGNC:42016 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as KIAA0649P2
PPP1R27, Official Symbol PPP1R27provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 27provided by HGNC Primary source HGNC:HGNC:16813 See related Ensembl:ENSG00000182676 AllianceGenome:HGNC:16813 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DYSFIP1 Summary Enables phosphatase binding activity. Predicted to be involved in negative regulation of catalytic activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in prostate (RPKM 3.7), esophagus (RPKM 0.9) and 3 other tissues See more Orthologs mouse all
PPP1R2B, Official Symbol PPP1R2Bprovided by HGNC Official Full Name PPP1R2 family member Bprovided by HGNC Primary source HGNC:HGNC:16318 See related Ensembl:ENSG00000231989 AllianceGenome:HGNC:16318 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPP1R2P3 Summary Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in regulation of phosphoprotein phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
PPP1R2C, Official Symbol PPP1R2Cprovided by HGNC Official Full Name PPP1R2C family member Cprovided by HGNC Primary source HGNC:HGNC:16324 See related Ensembl:ENSG00000102055 MIM:301017; AllianceGenome:HGNC:16324 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as I-4; PPP1R2P9 Summary Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in regulation of phosphoprotein phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022] Orthologs all
PPP1R2P1, Official Symbol PPP1R2P1provided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 1provided by HGNC Primary source HGNC:HGNC:9289 See related AllianceGenome:HGNC:9289 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IPP-2P; PPP1R2P Summary Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in regulation of phosphoprotein phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]
PPP1R2P10, Official Symbol PPP1R2P10provided by HGNC Official Full Name protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 10provided by HGNC Primary source HGNC:HGNC:42008 See related AllianceGenome:HGNC:42008 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
PPP1R35, Official Symbol PPP1R35provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 35provided by HGNC Primary source HGNC:HGNC:28320 See related Ensembl:ENSG00000160813 MIM:618937; AllianceGenome:HGNC:28320 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C7orf47 Summary Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 18.3), spleen (RPKM 14.1) and 25 other tissues See more Orthologs mouse all
PPP1R35-AS1, Official Symbol PPP1R35-AS1provided by HGNC Official Full Name PPP1R35 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41194 See related AllianceGenome:HGNC:41194 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 8.9), spleen (RPKM 5.6) and 25 other tissues See more
PPP1R36, Official Symbol PPP1R36provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 36provided by HGNC Primary source HGNC:HGNC:20097 See related Ensembl:ENSG00000165807 MIM:619923; AllianceGenome:HGNC:20097 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C14orf50 Summary Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in testis (RPKM 17.6), stomach (RPKM 2.2) and 4 other tissues See more Orthologs mouse all
PPP1R37, Official Symbol PPP1R37provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 37provided by HGNC Primary source HGNC:HGNC:27607 See related Ensembl:ENSG00000104866 AllianceGenome:HGNC:27607 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LRRC68 Summary Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in kidney (RPKM 8.3), brain (RPKM 8.2) and 25 other tissues See more Orthologs mouse all
PPP1R3A, Official Symbol PPP1R3Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Aprovided by HGNC Primary source HGNC:HGNC:9291 See related Ensembl:ENSG00000154415 MIM:600917; AllianceGenome:HGNC:9291 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GM; PP1G; PPP1R3 Summary The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008] Expression Restricted expression toward heart (RPKM 17.3) See more Orthologs mouse all
PPP1R3B, Official Symbol PPP1R3Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Bprovided by HGNC Primary source HGNC:HGNC:14942 See related Ensembl:ENSG00000173281 MIM:610541; AllianceGenome:HGNC:14942 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GL; PTG; PPP1R4 Summary This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011] Expression Broad expression in liver (RPKM 50.1), heart (RPKM 12.4) and 22 other tissues See more Orthologs mouse all
PPP1R3C, Official Symbol PPP1R3Cprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Cprovided by HGNC Primary source HGNC:HGNC:9293 See related Ensembl:ENSG00000119938 MIM:602999; AllianceGenome:HGNC:9293 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTG; PPP1R5 Summary This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016] Expression Broad expression in heart (RPKM 69.5), esophagus (RPKM 32.0) and 14 other tissues See more Orthologs mouse all
PPP1R3D, Official Symbol PPP1R3Dprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Dprovided by HGNC Primary source HGNC:HGNC:9294 See related Ensembl:ENSG00000132825 MIM:603326; AllianceGenome:HGNC:9294 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPP1R6 Summary Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. [provided by RefSeq, Jul 2008] Orthologs mouse all
PPP1R3E, Official Symbol PPP1R3Eprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Eprovided by HGNC Primary source HGNC:HGNC:14943 See related Ensembl:ENSG00000235194 MIM:619540; AllianceGenome:HGNC:14943 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable [phosphorylase] phosphatase activity; glycogen binding activity; and protein phosphatase 1 binding activity. Predicted to be involved in positive regulation of glycogen biosynthetic process. Predicted to be located in glycogen granule. Predicted to be part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in thyroid (RPKM 5.2), testis (RPKM 5.2) and 25 other tissues See more Orthologs mouse all
PPP1R3F, Official Symbol PPP1R3Fprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Fprovided by HGNC Primary source HGNC:HGNC:14944 See related Ensembl:ENSG00000049769 MIM:301104; AllianceGenome:HGNC:14944 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R3F; HB2E; LL0XNC01-7P3.1 Summary This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Broad expression in brain (RPKM 2.6), heart (RPKM 1.4) and 23 other tissues See more Orthologs mouse all
PPP1R3G, Official Symbol PPP1R3Gprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 3Gprovided by HGNC Primary source HGNC:HGNC:14945 See related Ensembl:ENSG00000219607 MIM:619541; AllianceGenome:HGNC:14945 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glucose homeostasis; positive regulation of glycogen (starch) synthase activity; and positive regulation of glycogen biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
PPP1R42, Official Symbol PPP1R42provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 42provided by HGNC Primary source HGNC:HGNC:33732 See related Ensembl:ENSG00000178125 MIM:617720; AllianceGenome:HGNC:33732 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as dtr; TLLR; TLRR; LRRC67 Summary The protein encoded by this gene can interact with gamma-tubulin and PP1 phosphatase, a regulator of centrosome separation. The encoded protein is a positive regulator of PP1 phosphatase and thus plays a role in the control of centrosome integrity. [provided by RefSeq, Feb 2017] Expression Restricted expression toward testis (RPKM 6.0) See more Orthologs mouse all
PPP1R7, Official Symbol PPP1R7provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 7provided by HGNC Primary source HGNC:HGNC:9295 See related Ensembl:ENSG00000115685 MIM:602877; AllianceGenome:HGNC:9295 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SDS22 Summary This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Expression Broad expression in testis (RPKM 40.9), brain (RPKM 18.7) and 25 other tissues See more Orthologs mouse all
PPP1R8, Official Symbol PPP1R8provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 8provided by HGNC Primary source HGNC:HGNC:9296 See related Ensembl:ENSG00000117751 MIM:602636; AllianceGenome:HGNC:9296 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ARD1; ARD-1; NIPP1; NIPP-1; PRO2047 Summary This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in endometrium (RPKM 13.4), lymph node (RPKM 13.2) and 25 other tissues See more Orthologs mouse all
PPP1R8P1, Official Symbol PPP1R8P1provided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 8 pseudogene 1provided by HGNC Primary source HGNC:HGNC:9297 See related Ensembl:ENSG00000224986 AllianceGenome:HGNC:9297 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPP1R8P
PPP1R9A, Official Symbol PPP1R9Aprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 9Aprovided by HGNC Primary source HGNC:HGNC:14946 See related Ensembl:ENSG00000158528 MIM:602468; AllianceGenome:HGNC:14946 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NRB1; NRBI; Neurabin-I Summary This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Expression Broad expression in brain (RPKM 4.9), adrenal (RPKM 2.5) and 21 other tissues See more Orthologs mouse all
PPP1R9A-AS1, Official Symbol PPP1R9A-AS1provided by HGNC Official Full Name PPP1R9A antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40696 See related Ensembl:ENSG00000236197 AllianceGenome:HGNC:40696 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
PPP1R9B, Official Symbol PPP1R9Bprovided by HGNC Official Full Name protein phosphatase 1 regulatory subunit 9Bprovided by HGNC Primary source HGNC:HGNC:9298 See related Ensembl:ENSG00000108819 MIM:603325; AllianceGenome:HGNC:9298 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Spn; SPINO; PPP1R6; PPP1R9 Summary This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in brain (RPKM 26.2), spleen (RPKM 25.4) and 24 other tissues See more Orthologs mouse all
PPP2CA, Official Symbol PPP2CAprovided by HGNC Official Full Name protein phosphatase 2 catalytic subunit alphaprovided by HGNC Primary source HGNC:HGNC:9299 See related Ensembl:ENSG00000113575 MIM:176915; AllianceGenome:HGNC:9299 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HJS3; RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha Summary This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 63.8), bone marrow (RPKM 57.1) and 25 other tissues See more Orthologs mouse all
PPP2CB, Official Symbol PPP2CBprovided by HGNC Official Full Name protein phosphatase 2 catalytic subunit betaprovided by HGNC Primary source HGNC:HGNC:9300 See related Ensembl:ENSG00000104695 MIM:176916; AllianceGenome:HGNC:9300 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PP2CB; PP2Abeta Summary This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in brain (RPKM 83.4), thyroid (RPKM 78.1) and 24 other tissues See more Orthologs mouse all
PPP2R1A, Official Symbol PPP2R1Aprovided by HGNC Official Full Name protein phosphatase 2 scaffold subunit Aalphaprovided by HGNC Primary source HGNC:HGNC:9302 See related Ensembl:ENSG00000105568 MIM:605983; AllianceGenome:HGNC:9302 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HJS2; MRD36; PP2AA; PR65A; PP2AAALPHA; PP2A-Aalpha Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] Expression Ubiquitous expression in heart (RPKM 78.3), adrenal (RPKM 73.7) and 25 other tissues See more Orthologs mouse all