psui3905/ncbi_genes_summary huggingface dataset:
IL17A, Official Symbol IL17Aprovided by HGNC Official Full Name interleukin 17Aprovided by HGNC Primary source HGNC:HGNC:5981 See related Ensembl:ENSG00000112115 MIM:603149; AllianceGenome:HGNC:5981 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL17; CTLA8; IL-17; ILA17; CTLA-8; IL-17A Summary This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Low expression observed in reference dataset See more Orthologs mouse all
IL17B, Official Symbol IL17Bprovided by HGNC Official Full Name interleukin 17Bprovided by HGNC Primary source HGNC:HGNC:5982 See related Ensembl:ENSG00000127743 MIM:604627; AllianceGenome:HGNC:5982 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NIRF; IL-20; IL-17B; ZCYTO7 Summary The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL17C, Official Symbol IL17Cprovided by HGNC Official Full Name interleukin 17Cprovided by HGNC Primary source HGNC:HGNC:5983 See related Ensembl:ENSG00000124391 MIM:604628; AllianceGenome:HGNC:5983 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CX2; IL-17C Summary The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008] Expression Biased expression in endometrium (RPKM 1.7), gall bladder (RPKM 0.2) and 1 other tissue See more Orthologs mouse all
IL17D, Official Symbol IL17Dprovided by HGNC Official Full Name interleukin 17Dprovided by HGNC Primary source HGNC:HGNC:5984 See related Ensembl:ENSG00000172458 MIM:607587; AllianceGenome:HGNC:5984 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-17D Summary The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues See more Orthologs mouse all
IL17F, Official Symbol IL17Fprovided by HGNC Official Full Name interleukin 17Fprovided by HGNC Primary source HGNC:HGNC:16404 See related Ensembl:ENSG00000112116 MIM:606496; AllianceGenome:HGNC:16404 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ML1; ML-1; IL17A; CANDF6; IL-17F Summary The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL17RA, Official Symbol IL17RAprovided by HGNC Official Full Name interleukin 17 receptor Aprovided by HGNC Primary source HGNC:HGNC:5985 See related Ensembl:ENSG00000177663 MIM:605461; AllianceGenome:HGNC:5985 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R Summary Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] Expression Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues See more Orthologs mouse all
IL17RB, Official Symbol IL17RBprovided by HGNC Official Full Name interleukin 17 receptor Bprovided by HGNC Primary source HGNC:HGNC:18015 See related Ensembl:ENSG00000056736 MIM:605458; AllianceGenome:HGNC:18015 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRL4; EVI27; IL17BR; IL17RH1 Summary The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008] Expression Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues See more Orthologs mouse all
IL17RC, Official Symbol IL17RCprovided by HGNC Official Full Name interleukin 17 receptor Cprovided by HGNC Primary source HGNC:HGNC:18358 See related Ensembl:ENSG00000163702 MIM:610925; AllianceGenome:HGNC:18358 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CANDF9; IL17RL; IL17-RL Summary This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues See more Orthologs mouse all
IL17RD, Official Symbol IL17RDprovided by HGNC Official Full Name interleukin 17 receptor Dprovided by HGNC Primary source HGNC:HGNC:17616 See related Ensembl:ENSG00000144730 MIM:606807; AllianceGenome:HGNC:17616 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SEF; HH18; IL-17RD; IL17RLM Summary This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016] Expression Broad expression in endometrium (RPKM 8.3), testis (RPKM 6.2) and 14 other tissues See more Orthologs mouse all
IL17RE, Official Symbol IL17REprovided by HGNC Official Full Name interleukin 17 receptor Eprovided by HGNC Primary source HGNC:HGNC:18439 See related Ensembl:ENSG00000163701 MIM:614995; AllianceGenome:HGNC:18439 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013] Expression Broad expression in duodenum (RPKM 10.6), skin (RPKM 9.9) and 17 other tissues See more Orthologs mouse all
IL17REL, Official Symbol IL17RELprovided by HGNC Official Full Name interleukin 17 receptor E likeprovided by HGNC Primary source HGNC:HGNC:33808 See related Ensembl:ENSG00000188263 MIM:613414; AllianceGenome:HGNC:33808 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable interleukin-17 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
IL18, Official Symbol IL18provided by HGNC Official Full Name interleukin 18provided by HGNC Primary source HGNC:HGNC:5986 See related Ensembl:ENSG00000150782 MIM:600953; AllianceGenome:HGNC:5986 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGIF; IL-18; IL-1g; IL1F4 Summary The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Biased expression in skin (RPKM 65.5), esophagus (RPKM 50.9) and 12 other tissues See more Orthologs mouse all
IL18BP, Official Symbol IL18BPprovided by HGNC Official Full Name interleukin 18 binding proteinprovided by HGNC Primary source HGNC:HGNC:5987 See related Ensembl:ENSG00000137496 MIM:604113; AllianceGenome:HGNC:5987 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FVH; IL18BPa Summary The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] Expression Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues See more Orthologs mouse all
IL18R1, Official Symbol IL18R1provided by HGNC Official Full Name interleukin 18 receptor 1provided by HGNC Primary source HGNC:HGNC:5988 See related Ensembl:ENSG00000115604 MIM:604494; AllianceGenome:HGNC:5988 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; IL-18Ralpha; IL18Ralpha2; IL-18R-alpha Summary The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Expression Broad expression in appendix (RPKM 4.6), gall bladder (RPKM 3.7) and 21 other tissues See more Orthologs mouse all
IL18RAP, Official Symbol IL18RAPprovided by HGNC Official Full Name interleukin 18 receptor accessory proteinprovided by HGNC Primary source HGNC:HGNC:5989 See related Ensembl:ENSG00000115607 MIM:604509; AllianceGenome:HGNC:5989 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta Summary The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] Expression Biased expression in bone marrow (RPKM 26.2), appendix (RPKM 5.0) and 4 other tissues See more Orthologs mouse all
IL19, Official Symbol IL19provided by HGNC Official Full Name interleukin 19provided by HGNC Primary source HGNC:HGNC:5990 See related Ensembl:ENSG00000142224 MIM:605687; AllianceGenome:HGNC:5990 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MDA1; NG.1; ZMDA1; IL-10C Summary The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL1A, Official Symbol IL1Aprovided by HGNC Official Full Name interleukin 1 alphaprovided by HGNC Primary source HGNC:HGNC:5991 See related Ensembl:ENSG00000115008 MIM:147760; AllianceGenome:HGNC:5991 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Biased expression in testis (RPKM 5.2), esophagus (RPKM 4.6) and 7 other tissues See more Orthologs mouse all
IL1B, Official Symbol IL1Bprovided by HGNC Official Full Name interleukin 1 betaprovided by HGNC Primary source HGNC:HGNC:5992 See related Ensembl:ENSG00000125538 MIM:147720; AllianceGenome:HGNC:5992 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-1; IL1F2; IL1beta; IL1-BETA Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Biased expression in bone marrow (RPKM 72.5), appendix (RPKM 32.9) and 12 other tissues See more Orthologs mouse all
IL1F10, Official Symbol IL1F10provided by HGNC Official Full Name interleukin 1 family member 10provided by HGNC Primary source HGNC:HGNC:15552 See related Ensembl:ENSG00000136697 MIM:615296; AllianceGenome:HGNC:15552 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] Expression Restricted expression toward skin (RPKM 1.0) See more Orthologs mouse all
IL1R1, Official Symbol IL1R1provided by HGNC Official Full Name interleukin 1 receptor type 1provided by HGNC Primary source HGNC:HGNC:5993 See related Ensembl:ENSG00000115594 MIM:147810; AllianceGenome:HGNC:5993 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P80; IL1R; CRMO3; IL1RA; CD121A; D2S1473; IL-1RT1; IL-1R-alpha Summary This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] Expression Ubiquitous expression in gall bladder (RPKM 42.4), placenta (RPKM 40.4) and 24 other tissues See more Orthologs mouse all
IL1R1-AS1, Official Symbol IL1R1-AS1provided by HGNC Official Full Name IL1R1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:53898 See related Ensembl:ENSG00000226925 AllianceGenome:HGNC:53898 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
IL1R2, Official Symbol IL1R2provided by HGNC Official Full Name interleukin 1 receptor type 2provided by HGNC Primary source HGNC:HGNC:5994 See related Ensembl:ENSG00000115590 MIM:147811; AllianceGenome:HGNC:5994 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2 Summary The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] Expression Biased expression in appendix (RPKM 4.1), bone marrow (RPKM 3.4) and 12 other tissues See more Orthologs mouse all
IL1RAP, Official Symbol IL1RAPprovided by HGNC Official Full Name interleukin 1 receptor accessory proteinprovided by HGNC Primary source HGNC:HGNC:5995 See related Ensembl:ENSG00000196083 MIM:602626; AllianceGenome:HGNC:5995 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL1R3; C3orf13; IL-1RAcP Summary This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018] Expression Broad expression in liver (RPKM 11.2), placenta (RPKM 7.8) and 21 other tissues See more Orthologs mouse all
IL1RAPL1, Official Symbol IL1RAPL1provided by HGNC Official Full Name interleukin 1 receptor accessory protein like 1provided by HGNC Primary source HGNC:HGNC:5996 See related Ensembl:ENSG00000169306 MIM:300206; AllianceGenome:HGNC:5996 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1 Summary The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL1RAPL2, Official Symbol IL1RAPL2provided by HGNC Official Full Name interleukin 1 receptor accessory protein like 2provided by HGNC Primary source HGNC:HGNC:5997 See related Ensembl:ENSG00000189108 MIM:300277; AllianceGenome:HGNC:5997 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL1R9; IL-1R9; TIGIRR-1; IL1RAPL-2 Summary The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic cognitive disability. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL1RL1, Official Symbol IL1RL1provided by HGNC Official Full Name interleukin 1 receptor like 1provided by HGNC Primary source HGNC:HGNC:5998 See related Ensembl:ENSG00000115602 MIM:601203; AllianceGenome:HGNC:5998 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R Summary The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] Annotation information Note: This gene, IL1RL1 (GeneID: 9173) which has the alias ST2, is found on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer. [23 Jun 2016] Expression Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues See more Orthologs mouse all
IL1RL2, Official Symbol IL1RL2provided by HGNC Official Full Name interleukin 1 receptor like 2provided by HGNC Primary source HGNC:HGNC:5999 See related Ensembl:ENSG00000115598 MIM:604512; AllianceGenome:HGNC:5999 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2 Summary The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues See more Orthologs mouse all
IL1RN, Official Symbol IL1RNprovided by HGNC Official Full Name interleukin 1 receptor antagonistprovided by HGNC Primary source HGNC:HGNC:6000 See related Ensembl:ENSG00000136689 MIM:147679; AllianceGenome:HGNC:6000 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIRA; IRAP; CRMO2; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Biased expression in esophagus (RPKM 367.9), bone marrow (RPKM 53.9) and 2 other tissues See more Orthologs mouse all
IL2, Official Symbol IL2provided by HGNC Official Full Name interleukin 2provided by HGNC Primary source HGNC:HGNC:6001 See related Ensembl:ENSG00000109471 MIM:147680; AllianceGenome:HGNC:6001 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-2; TCGF; lymphokine Summary This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response. Expression Low expression observed in reference dataset See more Orthologs mouse all
IL20, Official Symbol IL20provided by HGNC Official Full Name interleukin 20provided by HGNC Primary source HGNC:HGNC:6002 See related Ensembl:ENSG00000162891 MIM:605619; AllianceGenome:HGNC:6002 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL-20; IL10D; ZCYTO10 Summary The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL20RA, Official Symbol IL20RAprovided by HGNC Official Full Name interleukin 20 receptor subunit alphaprovided by HGNC Primary source HGNC:HGNC:6003 See related Ensembl:ENSG00000016402 MIM:605620; AllianceGenome:HGNC:6003 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha Summary This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Biased expression in skin (RPKM 13.8), adrenal (RPKM 3.9) and 13 other tissues See more Orthologs mouse all
IL20RB, Official Symbol IL20RBprovided by HGNC Official Full Name interleukin 20 receptor subunit betaprovided by HGNC Primary source HGNC:HGNC:6004 See related Ensembl:ENSG00000174564 MIM:605621; AllianceGenome:HGNC:6004 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DIRS1; FNDC6; IL-20R2 Summary IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009] Expression Biased expression in skin (RPKM 54.3) and esophagus (RPKM 20.8) See more Orthologs mouse all
IL21, Official Symbol IL21provided by HGNC Official Full Name interleukin 21provided by HGNC Primary source HGNC:HGNC:6005 See related Ensembl:ENSG00000138684 MIM:605384; AllianceGenome:HGNC:6005 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Za11; IL-21; CVID11 Summary This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Expression Biased expression in lymph node (RPKM 3.2), testis (RPKM 0.8) and 2 other tissues See more Orthologs mouse all
IL21-AS1, Official Symbol IL21-AS1provided by HGNC Official Full Name IL21 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:40299 See related Ensembl:ENSG00000227145 AllianceGenome:HGNC:40299 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Low expression observed in reference dataset See more
IL21R, Official Symbol IL21Rprovided by HGNC Official Full Name interleukin 21 receptorprovided by HGNC Primary source HGNC:HGNC:6006 See related Ensembl:ENSG00000103522 MIM:605383; AllianceGenome:HGNC:6006 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NILR; CD360; IMD56 Summary The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] Expression Biased expression in lymph node (RPKM 10.1), appendix (RPKM 5.4) and 7 other tissues See more Orthologs mouse all
IL21R-AS1, Official Symbol IL21R-AS1provided by HGNC Official Full Name IL21R antisense RNA 1provided by HGNC Primary source HGNC:HGNC:27551 See related Ensembl:ENSG00000259954 AllianceGenome:HGNC:27551 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in lymph node (RPKM 7.7), appendix (RPKM 4.1) and 8 other tissues See more
IL22, Official Symbol IL22provided by HGNC Official Full Name interleukin 22provided by HGNC Primary source HGNC:HGNC:14900 See related Ensembl:ENSG00000127318 MIM:605330; AllianceGenome:HGNC:14900 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23 Summary This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Note: This gene (GeneID: 50616) was identified as IL-21 or IL-TIF in PMID: 10954742. The official symbol for this gene is now IL22. [19 May 2011] Expression Low expression observed in reference dataset See more Orthologs all
IL22RA1, Official Symbol IL22RA1provided by HGNC Official Full Name interleukin 22 receptor subunit alpha 1provided by HGNC Primary source HGNC:HGNC:13700 See related Ensembl:ENSG00000142677 MIM:605457; AllianceGenome:HGNC:13700 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IL22R; CRF2-9; IL22R1 Summary The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008] Expression Biased expression in pancreas (RPKM 15.5), skin (RPKM 14.3) and 9 other tissues See more Orthologs mouse all
IL22RA2, Official Symbol IL22RA2provided by HGNC Official Full Name interleukin 22 receptor subunit alpha 2provided by HGNC Primary source HGNC:HGNC:14901 See related Ensembl:ENSG00000164485 MIM:606648; AllianceGenome:HGNC:14901 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2 Summary This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013] Expression Low expression observed in reference dataset See more Orthologs mouse all
IL23A, Official Symbol IL23Aprovided by HGNC Official Full Name interleukin 23 subunit alphaprovided by HGNC Primary source HGNC:HGNC:15488 See related Ensembl:ENSG00000110944 MIM:605580; AllianceGenome:HGNC:15488 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P19; SGRF; IL-23; IL-23A; IL23P19 Summary This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues See more Orthologs mouse all
IL23R, Official Symbol IL23Rprovided by HGNC Official Full Name interleukin 23 receptorprovided by HGNC Primary source HGNC:HGNC:19100 See related Ensembl:ENSG00000162594 MIM:607562; AllianceGenome:HGNC:19100 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PSORS7 Summary The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all