psui3905/ncbi_genes_summary huggingface dataset:
CD93, Official Symbol CD93provided by HGNC Official Full Name CD93 moleculeprovided by HGNC Primary source HGNC:HGNC:15855 See related Ensembl:ENSG00000125810 MIM:120577; AllianceGenome:HGNC:15855 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1 Summary The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008] Expression Broad expression in placenta (RPKM 64.0), lung (RPKM 47.5) and 21 other tissues See more Orthologs mouse all
CD96, Official Symbol CD96provided by HGNC Official Full Name CD96 moleculeprovided by HGNC Primary source HGNC:HGNC:16892 See related Ensembl:ENSG00000153283 MIM:606037; AllianceGenome:HGNC:16892 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TACTILE Summary The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016] Expression Broad expression in lymph node (RPKM 4.8), appendix (RPKM 2.7) and 15 other tissues See more Orthologs mouse all
CD99, Official Symbol CD99provided by HGNC Official Full Name CD99 molecule (Xg blood group)provided by HGNC Primary source HGNC:HGNC:7082 See related Ensembl:ENSG00000002586 Ensembl:ENSG00000292348 MIM:313470; MIM:450000; AllianceGenome:HGNC:7082 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIC2; HBA71; MIC2X; MIC2Y; MSK5X Summary The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016] Expression Ubiquitous expression in fat (RPKM 38.2), gall bladder (RPKM 35.8) and 25 other tissues See more Orthologs all
CD99L2, Official Symbol CD99L2provided by HGNC Official Full Name CD99 molecule like 2provided by HGNC Primary source HGNC:HGNC:18237 See related Ensembl:ENSG00000102181 MIM:300846; AllianceGenome:HGNC:18237 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD99B; MIC2L1 Summary This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Expression Ubiquitous expression in brain (RPKM 33.3), fat (RPKM 18.8) and 23 other tissues See more Orthologs mouse all
CDA, Official Symbol CDAprovided by HGNC Official Full Name cytidine deaminaseprovided by HGNC Primary source HGNC:HGNC:1712 See related Ensembl:ENSG00000158825 MIM:123920; AllianceGenome:HGNC:1712 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDD Summary This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008] Expression Biased expression in bone marrow (RPKM 57.6), esophagus (RPKM 22.6) and 8 other tissues See more Orthologs mouse all
CDADC1, Official Symbol CDADC1provided by HGNC Official Full Name cytidine and dCMP deaminase domain containing 1provided by HGNC Primary source HGNC:HGNC:20299 See related Ensembl:ENSG00000102543 MIM:618997; AllianceGenome:HGNC:20299 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NYD-SP15; bA103J18.1 Summary Enables several functions, including cytidine deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Involved in DNA cytosine deamination and cytidine deamination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in thyroid (RPKM 5.8), testis (RPKM 5.7) and 24 other tissues See more Orthologs mouse all
CDAN1, Official Symbol CDAN1provided by HGNC Official Full Name codanin 1provided by HGNC Primary source HGNC:HGNC:1713 See related Ensembl:ENSG00000140326 MIM:607465; AllianceGenome:HGNC:1713 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DLT; CDA1; CDAI; CDAN1A; PRO1295 Summary This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009] Expression Ubiquitous expression in ovary (RPKM 7.8), testis (RPKM 5.0) and 25 other tissues See more Orthologs mouse all
CDC123, Official Symbol CDC123provided by HGNC Official Full Name cell division cycle 123provided by HGNC Primary source HGNC:HGNC:16827 See related Ensembl:ENSG00000151465 MIM:617708; AllianceGenome:HGNC:16827 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as D123; C10orf7 Summary Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 28.2), appendix (RPKM 26.4) and 25 other tissues See more Orthologs mouse all
CDC14A, Official Symbol CDC14Aprovided by HGNC Official Full Name cell division cycle 14Aprovided by HGNC Primary source HGNC:HGNC:1718 See related Ensembl:ENSG00000079335 MIM:603504; AllianceGenome:HGNC:1718 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as cdc14; DFNB32; DFNB35; hCDC14; DFNB105 Summary The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues See more Orthologs mouse all
CDC14B, Official Symbol CDC14Bprovided by HGNC Official Full Name cell division cycle 14Bprovided by HGNC Primary source HGNC:HGNC:1719 See related Ensembl:ENSG00000081377 MIM:603505; AllianceGenome:HGNC:1719 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC14B3; Cdc14B1; Cdc14B2; hCDC14B Summary The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 5.3) and 25 other tissues See more Orthologs mouse all
CDC14C, Official Symbol CDC14Cprovided by HGNC Official Full Name cell division cycle 14Cprovided by HGNC Primary source HGNC:HGNC:22427 See related Ensembl:ENSG00000218305 AllianceGenome:HGNC:22427 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC14B2; CDC14Bretro Summary This gene represents a retrogene of cell division cycle 14B (CDC14B), which is located on chromosome 9. The introns in the coding sequence have been processed out relative to the CDC14B locus, but there is an intact open reading frame that is missing only some sequence at the N-terminus, including the nuclear localiztion signal, relative to proteins encoded by the CDC14B gene. There is a difference in the subcellular localization of the protein encoded by this gene, relative to its parental gene product. While the parental gene product displays microtubular localization, GFP chimeras of the protein encoded by this gene localize to the endoplasmic reticulum, indicating a possible new functional role for this gene. [provided by RefSeq, Nov 2017] Orthologs all
CDC16, Official Symbol CDC16provided by HGNC Official Full Name cell division cycle 16provided by HGNC Primary source HGNC:HGNC:1720 See related Ensembl:ENSG00000130177 MIM:603461; AllianceGenome:HGNC:1720 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APC6; CUT9; ANAPC6; CDC16Hs Summary The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016] Expression Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues See more Orthologs mouse all
CDC20, Official Symbol CDC20provided by HGNC Official Full Name cell division cycle 20provided by HGNC Primary source HGNC:HGNC:1723 See related Ensembl:ENSG00000117399 MIM:603618; AllianceGenome:HGNC:1723 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC20A; OOMD14; p55CDC; OZEMA14; bA276H19.3 Summary CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008] Expression Biased expression in testis (RPKM 26.5), bone marrow (RPKM 19.7) and 12 other tissues See more Orthologs mouse all
CDC20B, Official Symbol CDC20Bprovided by HGNC Official Full Name cell division cycle 20Bprovided by HGNC Primary source HGNC:HGNC:24222 See related Ensembl:ENSG00000164287 MIM:620335; AllianceGenome:HGNC:24222 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as G6VTS76519 Summary Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to be part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all
CDC20P1, Official Symbol CDC20P1provided by HGNC Official Full Name cell division cycle 20 pseudogene 1provided by HGNC Primary source HGNC:HGNC:29487 See related Ensembl:ENSG00000231007 AllianceGenome:HGNC:29487 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC20P
CDC23, Official Symbol CDC23provided by HGNC Official Full Name cell division cycle 23provided by HGNC Primary source HGNC:HGNC:1724 See related Ensembl:ENSG00000094880 MIM:603462; AllianceGenome:HGNC:1724 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APC8; CUT23; ANAPC8 Summary The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues See more Orthologs mouse all
CDC25A, Official Symbol CDC25Aprovided by HGNC Official Full Name cell division cycle 25Aprovided by HGNC Primary source HGNC:HGNC:1725 See related Ensembl:ENSG00000164045 MIM:116947; AllianceGenome:HGNC:1725 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC25A2 Summary CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Broad expression in testis (RPKM 7.4), bone marrow (RPKM 4.6) and 15 other tissues See more Orthologs mouse all
CDC25B, Official Symbol CDC25Bprovided by HGNC Official Full Name cell division cycle 25Bprovided by HGNC Primary source HGNC:HGNC:1726 See related Ensembl:ENSG00000101224 MIM:116949; AllianceGenome:HGNC:1726 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in lymph node (RPKM 21.4), appendix (RPKM 15.3) and 24 other tissues See more Orthologs mouse all
CDC25C, Official Symbol CDC25Cprovided by HGNC Official Full Name cell division cycle 25Cprovided by HGNC Primary source HGNC:HGNC:1727 See related Ensembl:ENSG00000158402 MIM:157680; AllianceGenome:HGNC:1727 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC25; PPP1R60 Summary This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015] Expression Biased expression in testis (RPKM 7.7), bone marrow (RPKM 1.3) and 8 other tissues See more Orthologs mouse all
CDC26, Official Symbol CDC26provided by HGNC Official Full Name cell division cycle 26provided by HGNC Primary source HGNC:HGNC:17839 See related Ensembl:ENSG00000176386 MIM:614533; AllianceGenome:HGNC:17839 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APC12; ANAPC12; C9orf17 Summary The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 9.9), appendix (RPKM 9.9) and 25 other tissues See more Orthologs mouse all
CDC27, Official Symbol CDC27provided by HGNC Official Full Name cell division cycle 27provided by HGNC Primary source HGNC:HGNC:1728 See related Ensembl:ENSG00000004897 MIM:116946; AllianceGenome:HGNC:1728 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E Summary The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014] Expression Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues See more Orthologs mouse all
CDC27P2, Official Symbol CDC27P2provided by HGNC Official Full Name cell division cycle 27 pseudogene 2provided by HGNC Primary source HGNC:HGNC:38092 See related Ensembl:ENSG00000237447 AllianceGenome:HGNC:38092 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CDC34, Official Symbol CDC34provided by HGNC Official Full Name cell division cycle 34, ubiqiutin conjugating enzymeprovided by HGNC Primary source HGNC:HGNC:1734 See related Ensembl:ENSG00000099804 MIM:116948; AllianceGenome:HGNC:1734 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UBC3; UBCH3; UBE2R1; E2-CDC34 Summary The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues See more Orthologs mouse all
CDC37, Official Symbol CDC37provided by HGNC Official Full Name cell division cycle 37, HSP90 cochaperoneprovided by HGNC Primary source HGNC:HGNC:1735 See related Ensembl:ENSG00000105401 MIM:605065; AllianceGenome:HGNC:1735 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P50CDC37 Summary The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in fat (RPKM 70.6), spleen (RPKM 61.9) and 25 other tissues See more Orthologs mouse all
CDC37L1, Official Symbol CDC37L1provided by HGNC Official Full Name cell division cycle 37 like 1, HSP90 cochaperoneprovided by HGNC Primary source HGNC:HGNC:17179 See related Ensembl:ENSG00000106993 MIM:610346; AllianceGenome:HGNC:17179 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HARC; CDC37B Summary CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008] Expression Ubiquitous expression in liver (RPKM 13.5), heart (RPKM 8.3) and 25 other tissues See more Orthologs mouse all
CDC37L1-DT, Official Symbol CDC37L1-DTprovided by HGNC Official Full Name CDC37L1 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:49735 See related Ensembl:ENSG00000273061 AllianceGenome:HGNC:49735 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC37L1-AS1 Expression Broad expression in kidney (RPKM 2.4), liver (RPKM 1.8) and 22 other tissues See more
CDC40, Official Symbol CDC40provided by HGNC Official Full Name cell division cycle 40provided by HGNC Primary source HGNC:HGNC:17350 See related Ensembl:ENSG00000168438 MIM:605585; AllianceGenome:HGNC:17350 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as EHB3; PCH15; PRP17; PRPF17 Summary Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 12.9), lymph node (RPKM 10.6) and 25 other tissues See more Orthologs mouse all
CDC42, Official Symbol CDC42provided by HGNC Official Full Name cell division cycle 42provided by HGNC Primary source HGNC:HGNC:1736 See related Ensembl:ENSG00000070831 MIM:116952; AllianceGenome:HGNC:1736 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TKS; G25K; CDC42Hs Summary The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] Expression Ubiquitous expression in bone marrow (RPKM 88.8), colon (RPKM 72.7) and 25 other tissues See more Orthologs mouse all
CDC42-AS1, Official Symbol CDC42-AS1provided by HGNC Official Full Name CDC42 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54314 See related AllianceGenome:HGNC:54314 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
CDC42-IT1, Official Symbol CDC42-IT1provided by HGNC Official Full Name CDC42 intronic transcript 1provided by HGNC Primary source HGNC:HGNC:41317 See related AllianceGenome:HGNC:41317 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release
CDC42BPA, Official Symbol CDC42BPAprovided by HGNC Official Full Name CDC42 binding protein kinase alphaprovided by HGNC Primary source HGNC:HGNC:1737 See related Ensembl:ENSG00000143776 MIM:603412; AllianceGenome:HGNC:1737 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRCK; MRCKA; PK428; MRCKalpha Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018] Expression Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues See more Orthologs mouse all
CDC42BPB, Official Symbol CDC42BPBprovided by HGNC Official Full Name CDC42 binding protein kinase betaprovided by HGNC Primary source HGNC:HGNC:1738 See related Ensembl:ENSG00000198752 MIM:614062; AllianceGenome:HGNC:1738 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRCKB; CHOCNS Summary This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in brain (RPKM 24.8), fat (RPKM 20.9) and 24 other tissues See more Orthologs mouse all
CDC42BPG, Official Symbol CDC42BPGprovided by HGNC Official Full Name CDC42 binding protein kinase gammaprovided by HGNC Primary source HGNC:HGNC:29829 See related Ensembl:ENSG00000171219 MIM:613991; AllianceGenome:HGNC:29829 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DMPK2; MRCKG; HSMDPKIN; KAPPA-200; MRCKgamma Summary Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cell leading edge; centriolar satellite; and cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in skin (RPKM 11.8), stomach (RPKM 5.1) and 20 other tissues See more Orthologs mouse all
CDC42EP1, Official Symbol CDC42EP1provided by HGNC Official Full Name CDC42 effector protein 1provided by HGNC Primary source HGNC:HGNC:17014 See related Ensembl:ENSG00000128283 MIM:606084; AllianceGenome:HGNC:17014 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEP1; BORG5; MSE55 Summary CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in stomach (RPKM 41.4), gall bladder (RPKM 17.9) and 24 other tissues See more Orthologs mouse all
CDC42EP2, Official Symbol CDC42EP2provided by HGNC Official Full Name CDC42 effector protein 2provided by HGNC Primary source HGNC:HGNC:16263 See related Ensembl:ENSG00000149798 MIM:606132; AllianceGenome:HGNC:16263 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEP2; BORG1 Summary CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011] Expression Ubiquitous expression in fat (RPKM 13.9), gall bladder (RPKM 10.2) and 23 other tissues See more Orthologs mouse all
CDC42EP3, Official Symbol CDC42EP3provided by HGNC Official Full Name CDC42 effector protein 3provided by HGNC Primary source HGNC:HGNC:16943 See related Ensembl:ENSG00000163171 MIM:606133; AllianceGenome:HGNC:16943 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as UB1; CEP3; BORG2 Summary This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Expression Broad expression in prostate (RPKM 28.7), endometrium (RPKM 27.8) and 23 other tissues See more Orthologs mouse all
CDC42EP4, Official Symbol CDC42EP4provided by HGNC Official Full Name CDC42 effector protein 4provided by HGNC Primary source HGNC:HGNC:17147 See related Ensembl:ENSG00000179604 MIM:605468; AllianceGenome:HGNC:17147 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEP4; BORG4; KAIA1777 Summary The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in ovary (RPKM 35.1), brain (RPKM 34.5) and 25 other tissues See more Orthologs mouse all
CDC42EP5, Official Symbol CDC42EP5provided by HGNC Official Full Name CDC42 effector protein 5provided by HGNC Primary source HGNC:HGNC:17408 See related Ensembl:ENSG00000167617 MIM:609171; AllianceGenome:HGNC:17408 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CEP5; Borg3 Summary Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013] Expression Biased expression in colon (RPKM 54.5), prostate (RPKM 21.2) and 11 other tissues See more Orthologs mouse all
CDC42P1, Official Symbol CDC42P1provided by HGNC Official Full Name CDC42 pseudogene 1provided by HGNC Primary source HGNC:HGNC:16339 See related Ensembl:ENSG00000234933 AllianceGenome:HGNC:16339 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as bK3216D2.3
CDC42SE1, Official Symbol CDC42SE1provided by HGNC Official Full Name CDC42 small effector 1provided by HGNC Primary source HGNC:HGNC:17719 See related Ensembl:ENSG00000197622 MIM:619456; AllianceGenome:HGNC:17719 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SCIP1; SPEC1 Summary Predicted to enable GTPase inhibitor activity. Predicted to be involved in signal transduction. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in spleen (RPKM 61.6), lymph node (RPKM 60.7) and 25 other tissues See more Orthologs mouse all
CDC42SE2, Official Symbol CDC42SE2provided by HGNC Official Full Name CDC42 small effector 2provided by HGNC Primary source HGNC:HGNC:18547 See related Ensembl:ENSG00000158985 MIM:619457; AllianceGenome:HGNC:18547 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPEC2 Summary Enables signaling adaptor activity. Involved in regulation of signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in lymph node (RPKM 52.2), appendix (RPKM 43.6) and 25 other tissues See more Orthologs mouse all
CDC45, Official Symbol CDC45provided by HGNC Official Full Name cell division cycle 45provided by HGNC Primary source HGNC:HGNC:1739 See related Ensembl:ENSG00000093009 MIM:603465; AllianceGenome:HGNC:1739 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC45L; MGORS7; CDC45L2; PORC-PI-1 Summary The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Biased expression in testis (RPKM 11.5), bone marrow (RPKM 6.8) and 11 other tissues See more Orthologs mouse all
CDC5L, Official Symbol CDC5Lprovided by HGNC Official Full Name cell division cycle 5 likeprovided by HGNC Primary source HGNC:HGNC:1743 See related Ensembl:ENSG00000096401 MIM:602868; AllianceGenome:HGNC:1743 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1 Summary The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 9.6), bone marrow (RPKM 8.1) and 25 other tissues See more Orthologs mouse all
CDC6, Official Symbol CDC6provided by HGNC Official Full Name cell division cycle 6provided by HGNC Primary source HGNC:HGNC:1744 See related Ensembl:ENSG00000094804 MIM:602627; AllianceGenome:HGNC:1744 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDC18L; HsCDC6; MGORS5; HsCDC18 Summary The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008] Expression Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues See more Orthologs mouse all
CDC7, Official Symbol CDC7provided by HGNC Official Full Name cell division cycle 7provided by HGNC Primary source HGNC:HGNC:1745 See related Ensembl:ENSG00000097046 MIM:603311; AllianceGenome:HGNC:1745 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Hsk1; CDC7L1; HsCDC7; huCDC7 Summary This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008] Expression Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues See more Orthologs mouse all
CDC73, Official Symbol CDC73provided by HGNC Official Full Name cell division cycle 73provided by HGNC Primary source HGNC:HGNC:16783 See related Ensembl:ENSG00000134371 MIM:607393; AllianceGenome:HGNC:16783 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28 Summary This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009] Expression Ubiquitous expression in thyroid (RPKM 11.2), prostate (RPKM 9.6) and 25 other tissues See more Orthologs mouse all
CDCA2, Official Symbol CDCA2provided by HGNC Official Full Name cell division cycle associated 2provided by HGNC Primary source HGNC:HGNC:14623 See related Ensembl:ENSG00000184661 MIM:618785; AllianceGenome:HGNC:14623 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PPP1R81; Repo-Man Summary This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] Expression Biased expression in testis (RPKM 7.7), lymph node (RPKM 1.9) and 9 other tissues See more Orthologs mouse all
CDCA3, Official Symbol CDCA3provided by HGNC Official Full Name cell division cycle associated 3provided by HGNC Primary source HGNC:HGNC:14624 See related Ensembl:ENSG00000111665 MIM:607749; AllianceGenome:HGNC:14624 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GRCC8; TOME1; TOME-1 Summary Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in testis (RPKM 6.4), duodenum (RPKM 3.8) and 20 other tissues See more Orthologs mouse all