psui3905/ncbi_genes_summary huggingface dataset:
CYP2C60P, Official Symbol CYP2C60Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 60, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42410 See related Ensembl:ENSG00000260863 AllianceGenome:HGNC:42410 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP2C8-de6b
CYP2C61P, Official Symbol CYP2C61Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 61, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39972 See related Ensembl:ENSG00000270648 AllianceGenome:HGNC:39972 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP2C8, Official Symbol CYP2C8provided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 8provided by HGNC Primary source HGNC:HGNC:2622 See related Ensembl:ENSG00000138115 MIM:601129; AllianceGenome:HGNC:2622 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPC8; CYPIIC8; CYP2C8DM; MP-12/MP-20 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Expression Restricted expression toward liver (RPKM 350.3) See more Orthologs all
CYP2C9, Official Symbol CYP2C9provided by HGNC Official Full Name cytochrome P450 family 2 subfamily C member 9provided by HGNC Primary source HGNC:HGNC:2623 See related Ensembl:ENSG00000138109 MIM:601130; AllianceGenome:HGNC:2623 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9; P450IIC9 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 331.8), duodenum (RPKM 60.3) and 1 other tissue See more Orthologs all
CYP2D6, Official Symbol CYP2D6provided by HGNC Official Full Name cytochrome P450 family 2 subfamily D member 6provided by HGNC Primary source HGNC:HGNC:2625 See related Ensembl:ENSG00000100197 MIM:124030; AllianceGenome:HGNC:2625 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] Expression Biased expression in liver (RPKM 40.1), small intestine (RPKM 14.6) and 2 other tissues See more Orthologs all
CYP2D7, Official Symbol CYP2D7provided by HGNC Official Full Name cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:2624 See related AllianceGenome:HGNC:2624 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP2D; CYP2D6; CYP2D@; CYP2D7P; P450C2D; P450DB1; CYP2D7AP; CYP2D7P1; RNA40057 Summary This gene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is a segregating pseudogene, where some individuals may have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. In this case, the functional allele is thought to be rare. This locus is part of a cluster of cytochrome P450 genes on chromosome 22. [provided by RefSeq, Jan 2017] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Broad expression in liver (RPKM 9.7), small intestine (RPKM 3.1) and 14 other tissues See more Orthologs all
CYP2E1, Official Symbol CYP2E1provided by HGNC Official Full Name cytochrome P450 family 2 subfamily E member 1provided by HGNC Primary source HGNC:HGNC:2631 See related Ensembl:ENSG00000130649 MIM:124040; AllianceGenome:HGNC:2631 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPE1; CYP2E; P450-J; P450C2E Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008] Expression Restricted expression toward liver (RPKM 2134.3) See more Orthologs mouse all
CYP2F1, Official Symbol CYP2F1provided by HGNC Official Full Name cytochrome P450 family 2 subfamily F member 1provided by HGNC Primary source HGNC:HGNC:2632 See related Ensembl:ENSG00000197446 MIM:124070; AllianceGenome:HGNC:2632 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2F1; CYP2F; CYPIIF1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs mouse all
CYP2G2P, Official Symbol CYP2G2Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily G member 2, pseudogeneprovided by HGNC Primary source HGNC:HGNC:15653 See related Ensembl:ENSG00000268101 AllianceGenome:HGNC:15653 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP2G2; CYP2GP2
CYP2J2, Official Symbol CYP2J2provided by HGNC Official Full Name cytochrome P450 family 2 subfamily J member 2provided by HGNC Primary source HGNC:HGNC:2634 See related Ensembl:ENSG00000134716 MIM:601258; AllianceGenome:HGNC:2634 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPJ2; CYPIIJ2 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016] Expression Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues See more Orthologs all
CYP2R1, Official Symbol CYP2R1provided by HGNC Official Full Name cytochrome P450 family 2 subfamily R member 1provided by HGNC Primary source HGNC:HGNC:20580 See related Ensembl:ENSG00000186104 MIM:608713; AllianceGenome:HGNC:20580 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in skin (RPKM 2.2), testis (RPKM 2.0) and 25 other tissues See more Orthologs mouse all
CYP2S1, Official Symbol CYP2S1provided by HGNC Official Full Name cytochrome P450 family 2 subfamily S member 1provided by HGNC Primary source HGNC:HGNC:15654 See related Ensembl:ENSG00000167600 MIM:611529; AllianceGenome:HGNC:15654 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPIIS1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008] Expression Biased expression in stomach (RPKM 58.7), duodenum (RPKM 46.6) and 7 other tissues See more Orthologs mouse all
CYP2T1P, Official Symbol CYP2T1Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily T member 1, pseudogeneprovided by HGNC Primary source HGNC:HGNC:18852 See related Ensembl:ENSG00000233622 AllianceGenome:HGNC:18852 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP2T2P
CYP2T3P, Official Symbol CYP2T3Pprovided by HGNC Official Full Name cytochrome P450 family 2 subfamily T member 3, pseudogeneprovided by HGNC Primary source HGNC:HGNC:18853 See related Ensembl:ENSG00000268529 AllianceGenome:HGNC:18853 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP2U1, Official Symbol CYP2U1provided by HGNC Official Full Name cytochrome P450 family 2 subfamily U member 1provided by HGNC Primary source HGNC:HGNC:20582 See related Ensembl:ENSG00000155016 MIM:610670; AllianceGenome:HGNC:20582 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SPG49; SPG56; P450TEC Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in prostate (RPKM 5.8), ovary (RPKM 5.2) and 24 other tissues See more Orthologs mouse all
CYP2U1-AS1, Official Symbol CYP2U1-AS1provided by HGNC Official Full Name CYP2U1 and SGMS2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:54817 See related Ensembl:ENSG00000245293 AllianceGenome:HGNC:54817 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in testis (RPKM 1.5), fat (RPKM 0.4) and 16 other tissues See more
CYP2W1, Official Symbol CYP2W1provided by HGNC Official Full Name cytochrome P450 family 2 subfamily W member 1provided by HGNC Primary source HGNC:HGNC:20243 See related Ensembl:ENSG00000073067 MIM:615967; AllianceGenome:HGNC:20243 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 2.9), duodenum (RPKM 2.7) and 8 other tissues See more Orthologs mouse all
CYP39A1, Official Symbol CYP39A1provided by HGNC Official Full Name cytochrome P450 family 39 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:17449 See related Ensembl:ENSG00000146233 MIM:605994; AllianceGenome:HGNC:17449 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Expression Broad expression in liver (RPKM 10.7), prostate (RPKM 4.4) and 14 other tissues See more Orthologs mouse all
CYP3A137P, Official Symbol CYP3A137Pprovided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 137, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42419 See related Ensembl:ENSG00000261511 AllianceGenome:HGNC:42419 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP3A4, Official Symbol CYP3A4provided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 4provided by HGNC Primary source HGNC:HGNC:2637 See related Ensembl:ENSG00000160868 MIM:124010; AllianceGenome:HGNC:2637 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as HLP; CP33; CP34; CYP3A; NF-25; VDDR3; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020] Expression Biased expression in liver (RPKM 476.5), small intestine (RPKM 282.8) and 1 other tissue See more Orthologs all
CYP3A43, Official Symbol CYP3A43provided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 43provided by HGNC Primary source HGNC:HGNC:17450 See related Ensembl:ENSG00000021461 MIM:606534; AllianceGenome:HGNC:17450 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] Expression Biased expression in liver (RPKM 2.4), testis (RPKM 0.3) and 1 other tissue See more Orthologs all
CYP3A5, Official Symbol CYP3A5provided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 5provided by HGNC Primary source HGNC:HGNC:2638 See related Ensembl:ENSG00000106258 MIM:605325; AllianceGenome:HGNC:2638 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP35; PCN3; CYPIIIA5; P450PCN3 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Biased expression in small intestine (RPKM 67.4), duodenum (RPKM 57.9) and 7 other tissues See more Orthologs all
CYP3A51P, Official Symbol CYP3A51Pprovided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 51, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42418 See related Ensembl:ENSG00000282277 AllianceGenome:HGNC:42418 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP3AP1; CYP3A5P1; CYP3A5-de13c; CYP3A5-de1b2b Summary This locus represents a CYP3A pseudogene that is present within a cluster of CYP3A (cytochrome P450, family 3, subfamily A) genes on chromosome 7. This pseudogene is located between the CYP3A7 and CYP3A5 family members. It contains duplicates of exons 1, 2 and 13 that are found in the functional genes. Readthrough transcription exists between the CYP3A7 gene and this pseudogene, where the readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of this pseudogene, as represented in GeneID:100861540. This pseudogene is not known to be independently transcribed. [provided by RefSeq, Feb 2012]
CYP3A52P, Official Symbol CYP3A52Pprovided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 52, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42412 See related Ensembl:ENSG00000260524 AllianceGenome:HGNC:42412 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP3A54P, Official Symbol CYP3A54Pprovided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 54, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42413 See related Ensembl:ENSG00000261809 AllianceGenome:HGNC:42413 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP3A7, Official Symbol CYP3A7provided by HGNC Official Full Name cytochrome P450 family 3 subfamily A member 7provided by HGNC Primary source HGNC:HGNC:2640 See related Ensembl:ENSG00000160870 MIM:605340; AllianceGenome:HGNC:2640 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP37; CYPIIIA7; P450HLp2; P450-HFLA; P-450111A7; P-450(HFL33) Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015] Expression Biased expression in liver (RPKM 26.8), gall bladder (RPKM 5.5) and 4 other tissues See more Orthologs all
CYP3A7-CYP3A51P, Official Symbol CYP3A7-CYP3A51Pprovided by HGNC Official Full Name CYP3A7-CYP3A51P readthroughprovided by HGNC Primary source HGNC:HGNC:51504 See related Ensembl:ENSG00000282301 AllianceGenome:HGNC:51504 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP3A7; CYPIIIA7; CYP3A7.1L; CYP3A7-3AP1; CYP3A7-CYP3AP1 Summary This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015] Expression Biased expression in liver (RPKM 21.3), gall bladder (RPKM 4.5) and 4 other tissues See more
CYP46A1, Official Symbol CYP46A1provided by HGNC Official Full Name cytochrome P450 family 46 subfamily A member 1provided by HGNC Primary source HGNC:HGNC:2641 See related Ensembl:ENSG00000036530 MIM:604087; AllianceGenome:HGNC:2641 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP46; CYP46 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008] Expression Biased expression in brain (RPKM 14.7), heart (RPKM 1.0) and 2 other tissues See more Orthologs mouse all
CYP4A11, Official Symbol CYP4A11provided by HGNC Official Full Name cytochrome P450 family 4 subfamily A member 11provided by HGNC Primary source HGNC:HGNC:2642 See related Ensembl:ENSG00000187048 MIM:601310; AllianceGenome:HGNC:2642 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CP4Y; CYP4A2; CYP4AII; CYPIVA11 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016] Expression Biased expression in liver (RPKM 280.4) and kidney (RPKM 130.2) See more Orthologs all
CYP4A22, Official Symbol CYP4A22provided by HGNC Official Full Name cytochrome P450 family 4 subfamily A member 22provided by HGNC Primary source HGNC:HGNC:20575 See related Ensembl:ENSG00000162365 MIM:615341; AllianceGenome:HGNC:20575 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] Expression Biased expression in liver (RPKM 60.8) and kidney (RPKM 24.2) See more
CYP4A22-AS1, Official Symbol CYP4A22-AS1provided by HGNC Official Full Name CYP4A22 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:43715 See related AllianceGenome:HGNC:43715 Gene type ncRNA Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ncRNA-a3 Annotation information not in current annotation release
CYP4A26P, Official Symbol CYP4A26Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily A member 26, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39980 See related AllianceGenome:HGNC:39980 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4A27P, Official Symbol CYP4A27Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily A member 27, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42414 See related Ensembl:ENSG00000261593 AllianceGenome:HGNC:42414 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4A43P, Official Symbol CYP4A43Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily A member 43, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42417 See related Ensembl:ENSG00000261196 AllianceGenome:HGNC:42417 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4A44P, Official Symbol CYP4A44Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily A member 44, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42416 See related Ensembl:ENSG00000261290 AllianceGenome:HGNC:42416 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4B1, Official Symbol CYP4B1provided by HGNC Official Full Name cytochrome P450 family 4 subfamily B member 1provided by HGNC Primary source HGNC:HGNC:2644 See related Ensembl:ENSG00000142973 MIM:124075; AllianceGenome:HGNC:2644 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPIVB1; P-450HP Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Biased expression in lung (RPKM 169.4), fat (RPKM 49.5) and 3 other tissues See more Orthologs mouse all
CYP4F11, Official Symbol CYP4F11provided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 11provided by HGNC Primary source HGNC:HGNC:13265 See related Ensembl:ENSG00000171903 MIM:611517; AllianceGenome:HGNC:13265 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPIVF11 Summary This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 19.6), gall bladder (RPKM 11.3) and 11 other tissues See more Orthologs all
CYP4F12, Official Symbol CYP4F12provided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 12provided by HGNC Primary source HGNC:HGNC:18857 See related Ensembl:ENSG00000186204 MIM:611485; AllianceGenome:HGNC:18857 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPIVF12; F22329_1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Biased expression in small intestine (RPKM 23.2), duodenum (RPKM 22.3) and 10 other tissues See more Orthologs all
CYP4F2, Official Symbol CYP4F2provided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 2provided by HGNC Primary source HGNC:HGNC:2645 See related Ensembl:ENSG00000186115 MIM:604426; AllianceGenome:HGNC:2645 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPF2 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008] Expression Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues See more
CYP4F22, Official Symbol CYP4F22provided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 22provided by HGNC Primary source HGNC:HGNC:26820 See related Ensembl:ENSG00000171954 MIM:611495; AllianceGenome:HGNC:26820 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LI3; ARCI5; INLNE Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008] Expression Biased expression in skin (RPKM 11.5), esophagus (RPKM 6.1) and 3 other tissues See more Orthologs mouse all
CYP4F23P, Official Symbol CYP4F23Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 23, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39944 See related AllianceGenome:HGNC:39944 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4F24P, Official Symbol CYP4F24Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 24, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39945 See related AllianceGenome:HGNC:39945 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in ovary (RPKM 1.4), gall bladder (RPKM 0.8) and 22 other tissues See more
CYP4F26P, Official Symbol CYP4F26Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 26, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39948 See related Ensembl:ENSG00000226562 AllianceGenome:HGNC:39948 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4F27P, Official Symbol CYP4F27Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 27, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39946 See related Ensembl:ENSG00000248313 AllianceGenome:HGNC:39946 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4F3, Official Symbol CYP4F3provided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 3provided by HGNC Primary source HGNC:HGNC:2646 See related Ensembl:ENSG00000186529 MIM:601270; AllianceGenome:HGNC:2646 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPF3; CYP4F; LTB4H; CYPIVF3 Summary This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019] Expression Biased expression in liver (RPKM 51.6), bone marrow (RPKM 29.9) and 6 other tissues See more Orthologs all
CYP4F30P, Official Symbol CYP4F30Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 30, pseudogeneprovided by HGNC Primary source HGNC:HGNC:25270 See related Ensembl:ENSG00000290699 AllianceGenome:HGNC:25270 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as C2orf14 Expression Biased expression in testis (RPKM 8.6) and prostate (RPKM 4.5) See more
CYP4F32P, Official Symbol CYP4F32Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 32, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39951 See related Ensembl:ENSG00000223564 AllianceGenome:HGNC:39951 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4F36P, Official Symbol CYP4F36Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 36, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42407 See related Ensembl:ENSG00000273330 AllianceGenome:HGNC:42407 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4F44P, Official Symbol CYP4F44Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 44, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39957 See related Ensembl:ENSG00000253748 AllianceGenome:HGNC:39957 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4F60P, Official Symbol CYP4F60Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 60, pseudogeneprovided by HGNC Primary source HGNC:HGNC:42468 See related Ensembl:ENSG00000230635 AllianceGenome:HGNC:42468 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4F62P, Official Symbol CYP4F62Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 62, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39956 See related Ensembl:ENSG00000290599 AllianceGenome:HGNC:39956 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYP4F43P Expression Biased expression in testis (RPKM 8.1) and prostate (RPKM 4.1) See more
CYP4F8, Official Symbol CYP4F8provided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 8provided by HGNC Primary source HGNC:HGNC:2648 See related Ensembl:ENSG00000186526 MIM:611545; AllianceGenome:HGNC:2648 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CPF8; CYPIVF8 Summary This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008] Expression Biased expression in prostate (RPKM 2.3), skin (RPKM 0.2) and 2 other tissues See more Orthologs all
CYP4F9P, Official Symbol CYP4F9Pprovided by HGNC Official Full Name cytochrome P450 family 4 subfamily F member 9, pseudogeneprovided by HGNC Primary source HGNC:HGNC:39940 See related AllianceGenome:HGNC:39940 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
CYP4V2, Official Symbol CYP4V2provided by HGNC Official Full Name cytochrome P450 family 4 subfamily V member 2provided by HGNC Primary source HGNC:HGNC:23198 See related Ensembl:ENSG00000145476 MIM:608614; AllianceGenome:HGNC:23198 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as BCD; CYP4AH1 Summary This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in liver (RPKM 27.9), kidney (RPKM 21.3) and 23 other tissues See more Orthologs mouse all
CYP4X1, Official Symbol CYP4X1provided by HGNC Official Full Name cytochrome P450 family 4 subfamily X member 1provided by HGNC Primary source HGNC:HGNC:20244 See related Ensembl:ENSG00000186377 MIM:614999; AllianceGenome:HGNC:20244 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CYPIVX1 Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Expression Broad expression in prostate (RPKM 4.4), lung (RPKM 4.1) and 23 other tissues See more Orthologs mouse all