psui3905/ncbi_genes_summary huggingface dataset:
CD177, Official Symbol CD177provided by HGNC Official Full Name CD177 moleculeprovided by HGNC Primary source HGNC:HGNC:30072 See related Ensembl:ENSG00000204936 MIM:162860; AllianceGenome:HGNC:30072 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP Summary This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014] Expression Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue See more Orthologs all
CD180, Official Symbol CD180provided by HGNC Official Full Name CD180 moleculeprovided by HGNC Primary source HGNC:HGNC:6726 See related Ensembl:ENSG00000134061 MIM:602226; AllianceGenome:HGNC:6726 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LY64; Ly78; RP105 Summary CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 23.1), spleen (RPKM 12.8) and 10 other tissues See more Orthologs mouse all
CD19, Official Symbol CD19provided by HGNC Official Full Name CD19 moleculeprovided by HGNC Primary source HGNC:HGNC:1633 See related Ensembl:ENSG00000177455 MIM:107265; AllianceGenome:HGNC:1633 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B4; CVID3 Summary This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. Expression Biased expression in lymph node (RPKM 43.1), spleen (RPKM 28.3) and 3 other tissues See more Orthologs mouse all
CD1A, Official Symbol CD1Aprovided by HGNC Official Full Name CD1a moleculeprovided by HGNC Primary source HGNC:HGNC:1634 See related Ensembl:ENSG00000158477 MIM:188370; AllianceGenome:HGNC:1634 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R4; T6; CD1; FCB6; HTA1 Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] Expression Biased expression in skin (RPKM 10.0), esophagus (RPKM 4.8) and 4 other tissues See more Orthologs all
CD1B, Official Symbol CD1Bprovided by HGNC Official Full Name CD1b moleculeprovided by HGNC Primary source HGNC:HGNC:1635 See related Ensembl:ENSG00000158485 MIM:188360; AllianceGenome:HGNC:1635 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R1; CD1; CD1A Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008] Expression Low expression observed in reference dataset See more Orthologs all
CD1C, Official Symbol CD1Cprovided by HGNC Official Full Name CD1c moleculeprovided by HGNC Primary source HGNC:HGNC:1636 See related Ensembl:ENSG00000158481 MIM:188340; AllianceGenome:HGNC:1636 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R7; CD1; CD1A; BDCA1 Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 8.6), appendix (RPKM 6.9) and 15 other tissues See more Orthologs all
CD1D, Official Symbol CD1Dprovided by HGNC Official Full Name CD1d moleculeprovided by HGNC Primary source HGNC:HGNC:1637 See related Ensembl:ENSG00000158473 IMGT/GENE-DB:CD1D; MIM:188410; AllianceGenome:HGNC:1637 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R3; CD1A; R3G1 Summary This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] Expression Broad expression in appendix (RPKM 5.0), spleen (RPKM 5.0) and 17 other tissues See more Orthologs mouse all
CD1E, Official Symbol CD1Eprovided by HGNC Official Full Name CD1e moleculeprovided by HGNC Primary source HGNC:HGNC:1638 See related Ensembl:ENSG00000158488 MIM:188411; AllianceGenome:HGNC:1638 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as R2; CD1A Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010] Expression Broad expression in skin (RPKM 3.1), esophagus (RPKM 2.3) and 18 other tissues See more Orthologs all
CD2, Official Symbol CD2provided by HGNC Official Full Name CD2 moleculeprovided by HGNC Primary source HGNC:HGNC:1639 See related Ensembl:ENSG00000116824 MIM:186990; AllianceGenome:HGNC:1639 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T11; SRBC; LFA-2 Summary The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016] Expression Biased expression in lymph node (RPKM 56.3), appendix (RPKM 28.1) and 10 other tissues See more Orthologs mouse all
CD200, Official Symbol CD200provided by HGNC Official Full Name CD200 moleculeprovided by HGNC Primary source HGNC:HGNC:7203 See related Ensembl:ENSG00000091972 MIM:155970; AllianceGenome:HGNC:7203 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MRC; MOX1; MOX2; OX-2 Summary This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Expression Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues See more Orthologs mouse all
CD200R1, Official Symbol CD200R1provided by HGNC Official Full Name CD200 receptor 1provided by HGNC Primary source HGNC:HGNC:24235 See related Ensembl:ENSG00000163606 MIM:607546; AllianceGenome:HGNC:24235 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OX2R; MOX2R; CD200R; HCRTR2 Summary This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] Expression Broad expression in spleen (RPKM 4.6), placenta (RPKM 2.9) and 22 other tissues See more Orthologs mouse all
CD200R1L, Official Symbol CD200R1Lprovided by HGNC Official Full Name CD200 receptor 1 likeprovided by HGNC Primary source HGNC:HGNC:24665 See related Ensembl:ENSG00000206531 AllianceGenome:HGNC:24665 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD200R2; CD200RLa Summary Predicted to enable signaling receptor activity. Predicted to be involved in regulation of neuroinflammatory response. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Annotation information Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. Expression Low expression observed in reference dataset See more Orthologs all
CD207, Official Symbol CD207provided by HGNC Official Full Name CD207 moleculeprovided by HGNC Primary source HGNC:HGNC:17935 See related Ensembl:ENSG00000116031 MIM:604862; AllianceGenome:HGNC:17935 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLEC4K Summary The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010] Expression Biased expression in skin (RPKM 26.1), esophagus (RPKM 6.2) and 1 other tissue See more Orthologs mouse all
CD209, Official Symbol CD209provided by HGNC Official Full Name CD209 moleculeprovided by HGNC Primary source HGNC:HGNC:1641 See related Ensembl:ENSG00000090659 MIM:604672; AllianceGenome:HGNC:1641 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN Summary This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020] Annotation information Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection. Expression Broad expression in placenta (RPKM 11.4), lymph node (RPKM 9.5) and 17 other tissues See more Orthologs all
CD22, Official Symbol CD22provided by HGNC Official Full Name CD22 moleculeprovided by HGNC Primary source HGNC:HGNC:1643 See related Ensembl:ENSG00000012124 MIM:107266; AllianceGenome:HGNC:1643 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as SIGLEC2; SIGLEC-2 Summary Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022] Expression Biased expression in lymph node (RPKM 101.0), ovary (RPKM 64.7) and 2 other tissues See more Orthologs mouse all
CD226, Official Symbol CD226provided by HGNC Official Full Name CD226 moleculeprovided by HGNC Primary source HGNC:HGNC:16961 See related Ensembl:ENSG00000150637 MIM:605397; AllianceGenome:HGNC:16961 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as PTA1; DNAM1; DNAM-1; TLiSA1 Summary This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] Expression Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues See more Orthologs mouse all
CD24, Official Symbol CD24provided by HGNC Official Full Name CD24 moleculeprovided by HGNC Primary source HGNC:HGNC:1645 See related Ensembl:ENSG00000272398 MIM:600074; AllianceGenome:HGNC:1645 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD24A Summary This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Expression Biased expression in thyroid (RPKM 586.8), esophagus (RPKM 431.3) and 12 other tissues See more Orthologs mouse all
CD244, Official Symbol CD244provided by HGNC Official Full Name CD244 moleculeprovided by HGNC Primary source HGNC:HGNC:18171 See related Ensembl:ENSG00000122223 MIM:605554; AllianceGenome:HGNC:18171 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 2B4; NAIL; Nmrk; NKR2B4; SLAMF4 Summary This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Expression Biased expression in spleen (RPKM 7.3), bone marrow (RPKM 3.3) and 12 other tissues See more Orthologs mouse all
CD247, Official Symbol CD247provided by HGNC Official Full Name CD247 moleculeprovided by HGNC Primary source HGNC:HGNC:1677 See related Ensembl:ENSG00000198821 MIM:186780; AllianceGenome:HGNC:1677 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T3Z; CD3H; CD3Q; CD3Z; TCRZ; IMD25; CD3ZETA; CD3-ZETA Summary The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 25.8), spleen (RPKM 18.4) and 11 other tissues See more Orthologs mouse all
CD248, Official Symbol CD248provided by HGNC Official Full Name CD248 moleculeprovided by HGNC Primary source HGNC:HGNC:18219 See related Ensembl:ENSG00000174807 MIM:606064; AllianceGenome:HGNC:18219 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as TEM1; CD164L1 Summary Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Predicted to be involved in cell migration. Predicted to act upstream of or within several processes, including anatomical structure regression; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022] Orthologs mouse all
CD24P1, Official Symbol CD24P1provided by HGNC Official Full Name CD24 molecule pseudogene 1provided by HGNC Primary source HGNC:HGNC:1646 See related AllianceGenome:HGNC:1646 Gene type pseudo RefSeq status INFERRED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD24L1
CD27, Official Symbol CD27provided by HGNC Official Full Name CD27 moleculeprovided by HGNC Primary source HGNC:HGNC:11922 See related Ensembl:ENSG00000139193 MIM:186711; AllianceGenome:HGNC:11922 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as T14; S152; Tp55; TNFRSF7; S152. LPFS2 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] Expression Broad expression in lymph node (RPKM 38.5), spleen (RPKM 21.6) and 14 other tissues See more Orthologs mouse all
CD27-AS1, Official Symbol CD27-AS1provided by HGNC Official Full Name CD27 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:43896 See related Ensembl:ENSG00000215039 AllianceGenome:HGNC:43896 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in lymph node (RPKM 17.7), spleen (RPKM 11.3) and 23 other tissues See more
CD274, Official Symbol CD274provided by HGNC Official Full Name CD274 moleculeprovided by HGNC Primary source HGNC:HGNC:17635 See related Ensembl:ENSG00000120217 MIM:605402; AllianceGenome:HGNC:17635 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1 Summary This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Expression Broad expression in appendix (RPKM 6.7), placenta (RPKM 4.5) and 23 other tissues See more Orthologs mouse all
CD276, Official Symbol CD276provided by HGNC Official Full Name CD276 moleculeprovided by HGNC Primary source HGNC:HGNC:19137 See related Ensembl:ENSG00000103855 MIM:605715; AllianceGenome:HGNC:19137 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as B7H3; B7-H3; B7RP-2; 4Ig-B7-H3 Summary The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Expression Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues See more Orthologs mouse all
CD28, Official Symbol CD28provided by HGNC Official Full Name CD28 moleculeprovided by HGNC Primary source HGNC:HGNC:1653 See related Ensembl:ENSG00000178562 MIM:186760; AllianceGenome:HGNC:1653 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as Tp44 Summary The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] Expression Biased expression in lymph node (RPKM 11.2), appendix (RPKM 7.3) and 7 other tissues See more Orthologs mouse all
CD2AP, Official Symbol CD2APprovided by HGNC Official Full Name CD2 associated proteinprovided by HGNC Primary source HGNC:HGNC:14258 See related Ensembl:ENSG00000198087 MIM:604241; AllianceGenome:HGNC:14258 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CMS Summary This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in small intestine (RPKM 31.9), duodenum (RPKM 29.7) and 25 other tissues See more Orthologs mouse all
CD2BP2, Official Symbol CD2BP2provided by HGNC Official Full Name CD2 cytoplasmic tail binding protein 2provided by HGNC Primary source HGNC:HGNC:1656 See related Ensembl:ENSG00000169217 MIM:604470; AllianceGenome:HGNC:1656 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIN1; Snu40; FWP010; U5-52K; PPP1R59 Summary This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008] Expression Ubiquitous expression in brain (RPKM 16.4), lymph node (RPKM 14.8) and 25 other tissues See more Orthologs mouse all
CD2BP2-DT, Official Symbol CD2BP2-DTprovided by HGNC Official Full Name CD2BP2 divergent transcriptprovided by HGNC Primary source HGNC:HGNC:53029 See related AllianceGenome:HGNC:53029 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Ubiquitous expression in thyroid (RPKM 1.5), colon (RPKM 1.3) and 25 other tissues See more
CD300A, Official Symbol CD300Aprovided by HGNC Official Full Name CD300a moleculeprovided by HGNC Primary source HGNC:HGNC:19319 See related Ensembl:ENSG00000167851 MIM:606790; AllianceGenome:HGNC:19319 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9 Summary This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] Expression Broad expression in spleen (RPKM 24.5), appendix (RPKM 12.1) and 14 other tissues See more Orthologs mouse all
CD300C, Official Symbol CD300Cprovided by HGNC Official Full Name CD300c moleculeprovided by HGNC Primary source HGNC:HGNC:19320 See related Ensembl:ENSG00000167850 MIM:606786; AllianceGenome:HGNC:19320 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1 Summary The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008] Expression Broad expression in lung (RPKM 2.9), appendix (RPKM 2.6) and 19 other tissues See more Orthologs mouse all
CD300E, Official Symbol CD300Eprovided by HGNC Official Full Name CD300e moleculeprovided by HGNC Primary source HGNC:HGNC:28874 See related Ensembl:ENSG00000186407 MIM:609801; AllianceGenome:HGNC:28874 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5 Summary This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012] Expression Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues See more Orthologs all
CD300H, Official Symbol CD300Hprovided by HGNC Official Full Name CD300H molecule (gene/pseudogene)provided by HGNC Primary source HGNC:HGNC:52292 See related Ensembl:ENSG00000284690 MIM:616560; AllianceGenome:HGNC:52292 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CD300Hs Summary This gene belongs to the CD300 gene family, which in turn, belongs to the immunoglobulin (Ig) superfamily. This gene is located within a CD300 cluster on chromosome 17. The encoded protein may be involved in innate immunity as well as autoimmune response. A G>A mutation, represented by the single nucleotide polymorphism (SNP) rs905709, at the splice donor site of the 5' terminal exon may be associated with lack of expression of this gene in homozygous (AA) individuals. The human reference assembly (GRCh38.p2) represents the 'A' allele at this SNP. [provided by RefSeq, Apr 2016] Annotation information Annotation category: suggests misassembly Expression Biased expression in spleen (RPKM 1.3), appendix (RPKM 0.8) and 5 other tissues See more Orthologs all
CD300LB, Official Symbol CD300LBprovided by HGNC Official Full Name CD300 molecule like family member bprovided by HGNC Primary source HGNC:HGNC:30811 See related Ensembl:ENSG00000178789 MIM:610705; AllianceGenome:HGNC:30811 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLM7; CLM-7; IREM3; TREM5; CD300b; IREM-3; TREM-5; CMRF35-A2 Summary CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008] Expression Biased expression in appendix (RPKM 4.4), bone marrow (RPKM 2.5) and 11 other tissues See more Orthologs mouse all
CD300LD, Official Symbol CD300LDprovided by HGNC Official Full Name CD300 molecule like family member dprovided by HGNC Primary source HGNC:HGNC:16848 See related Ensembl:ENSG00000204345 MIM:616301; AllianceGenome:HGNC:16848 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLM-4; CLM-5; CD300D; CMRF35A4; CMRF35-A4 Summary Predicted to enable transmembrane signaling receptor activity and virus receptor activity. Predicted to be involved in immune system process. Predicted to act upstream of or within regulation of interleukin-6 production and regulation of tumor necrosis factor production. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs all
CD300LF, Official Symbol CD300LFprovided by HGNC Official Full Name CD300 molecule like family member fprovided by HGNC Primary source HGNC:HGNC:29883 See related Ensembl:ENSG00000186074 MIM:609807; AllianceGenome:HGNC:29883 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLM1; NKIR; CLM-1; IREM1; LMIR3; CD300f; IREM-1; IgSF13 Summary This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Expression Biased expression in spleen (RPKM 9.3), bone marrow (RPKM 8.2) and 10 other tissues See more Orthologs mouse all
CD300LG, Official Symbol CD300LGprovided by HGNC Official Full Name CD300 molecule like family member gprovided by HGNC Primary source HGNC:HGNC:30455 See related Ensembl:ENSG00000161649 MIM:610520; AllianceGenome:HGNC:30455 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as CLM9; CLM-9; TREM4; TREM-4; NEPMUCIN Summary Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008] Expression Biased expression in fat (RPKM 45.4), placenta (RPKM 12.3) and 3 other tissues See more Orthologs mouse all
CD302, Official Symbol CD302provided by HGNC Official Full Name CD302 moleculeprovided by HGNC Primary source HGNC:HGNC:30843 See related Ensembl:ENSG00000241399 MIM:612246; AllianceGenome:HGNC:30843 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as DCL1; DCL-1; BIMLEC; CLEC13A Summary CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008] Expression Ubiquitous expression in liver (RPKM 51.3), lung (RPKM 34.3) and 25 other tissues See more Orthologs mouse all
CD320, Official Symbol CD320provided by HGNC Official Full Name CD320 moleculeprovided by HGNC Primary source HGNC:HGNC:16692 See related Ensembl:ENSG00000167775 MIM:606475; AllianceGenome:HGNC:16692 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as 8D6; 8D6A; TCBLR; TCN2R; TCII-R; sCD320 Summary This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] Expression Ubiquitous expression in spleen (RPKM 26.7), colon (RPKM 20.1) and 25 other tissues See more Orthologs mouse all
CD33, Official Symbol CD33provided by HGNC Official Full Name CD33 moleculeprovided by HGNC Primary source HGNC:HGNC:1659 See related Ensembl:ENSG00000105383 MIM:159590; AllianceGenome:HGNC:1659 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as p67; SIGLEC3; SIGLEC-3 Summary Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Apr 2022] Expression Broad expression in spleen (RPKM 7.5), bone marrow (RPKM 6.6) and 19 other tissues See more Orthologs mouse all
CD34, Official Symbol CD34provided by HGNC Official Full Name CD34 moleculeprovided by HGNC Primary source HGNC:HGNC:1662 See related Ensembl:ENSG00000174059 MIM:142230; AllianceGenome:HGNC:1662 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] Expression Broad expression in placenta (RPKM 110.3), fat (RPKM 76.9) and 19 other tissues See more Orthologs mouse all
CD36, Official Symbol CD36provided by HGNC Official Full Name CD36 moleculeprovided by HGNC Primary source HGNC:HGNC:1663 See related Ensembl:ENSG00000135218 MIM:173510; AllianceGenome:HGNC:1663 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10 Summary The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014] Expression Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues See more Orthologs mouse all
CD37, Official Symbol CD37provided by HGNC Official Full Name CD37 moleculeprovided by HGNC Primary source HGNC:HGNC:1666 See related Ensembl:ENSG00000104894 MIM:151523; AllianceGenome:HGNC:1666 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GP52-40; TSPAN26 Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Expression Biased expression in lymph node (RPKM 111.7), spleen (RPKM 99.3) and 8 other tissues See more Orthologs mouse all