S20 Table: Mitoxantrone significantly affects the expression of the selected 163 genes as evident in the "LINCS L1000 Chem Pert up" category in Enrichr. The last number after the -is dose density. Term Overlap P-value Adjusted P-value LINCS L1000 Chem Pert up LJP005 HEPG2 24H-mitoxantrone-0.37 19/142 5.43 × 10 −18 1.06 × 10 −14 LJP005 HEPG2 24H-mitoxantrone-0.12 14/110 3.03 × 10 −13 9.65 × 10 −11 LJP006 MCF7 24H-mitoxantrone-0.37 12/91 1.03 × 10 −11 1.81 × 10 −9 LJP006 MCF7 24H-mitoxantrone-3. 33 13/122 2.20 × 10 −11 3.30 × 10 −9 LJP005 HEPG2 24H-mitoxantrone-1.11 13/130 4.96 × 10 −11 6.44 × 10 −9 LJP006 SKBR3 24H-mitoxantrone-0. Table: (Continued) LJP005 HCC515 24H-mitoxantrone-1.11 7/126 7.87 × 10 −5 9.37 × 10 −4 CPC020 PC3 6H-mitoxantrone dihydrochloride-10.0 6/89 8.89 × 10 −5 1.04 × 10 −3 LJP005 SKBR3 3H-mitoxantrone-0.37 5/56 9.23 × 10 −5 1.07 × 10 −3 LJP005 A549 24H-mitoxantrone-3.33 8/182 1.26 × 10 −4 1.40 × 10 −3 LJP006 HA1E 24H-mitoxantrone-0.37 8/183 1.31 × 10 −4 1.43 × 10 −3 CPC020 PC3 24H-mitoxantrone dihydrochloride-10.0 8/189 1.64 × 10 −4 1.72 × 10 −3 LJP005 A375 24H-mitoxantrone-0.12 7/145 1.89 × 10 −4 1.93 × 10 −3 LJP005 MCF10A 24H-mitoxantrone-0.37 6/106 2.33 × 10 −4 2.31 × 10 −3 LJP006 HME1 3H-mitoxantrone-3.33 5/70 2.67 × 10 −4 2.60 × 10 −3 LJP006 A549 24H-mitoxantrone-0.12 6/109 2.71 × 10 −4 2.63 × 10 −3 LJP006 HT29 24H-mitoxantrone-0.37 4/39 2.80 × 10 −4 2.71 × 10 −3 LJP006 SKBR3 3H-mitoxantrone-3.33 4/39 2.80 × 10 −4 2.71 × 10 −3 LJP006 MCF10A 3H-mitoxantrone-0.12 4/40 3.09 × 10 −4 2.93 × 10 −3 LJP006 A549 24H-mitoxantrone-0.37 6/112 3.14 × 10 −4 2.97 × 10 −3 LJP006 HCC515 24H-mitoxantrone-3.33 7/160 3.45 × 10 −4 3.22 × 10 −3 LJP006 MDAMB231 3H-mitoxantrone-0.37 5/74 3.46 × 10 −4 3.21 × 10 −3 LJP006 MCF10A 3H-mitoxantrone-0.37 4/42 3.74 × 10 −4 3.44 × 10 −3 LJP005 SKBR3 24H-mitoxantrone-1.11 6/117 3.97 × 10 −4 3.62 × 10 −3 LJP006 PC3 24H-mitoxantrone-1.11 6/117 3.97 × 10 −4 3.62 × 10 −3 LJP005 MCF10A 3H-mitoxantrone-1.11 4/43 4.10 × 10 −4 3.72 × 10 −3 LJP006 HCC515 24H-mitoxantrone-0.37 6/121 4.75 × 10 −4 4.20 × 10 −3 LJP007 HT29 24H-mitoxantrone-10 6/123 5.18 × 10 −4 4.53 × 10 −3 LJP006 MDAMB231 3H-mitoxantrone-3.33 4/46 5.31 × 10 −4 4.62 × 10 −3 LJP005 HT29 24H-mitoxantrone-0.37 5/82 5.56 × 10 −4 4.82 × 10 −3 LJP005 MCF7 24H-mitoxantrone-0.37 5/82 5.56 × 10 −4 4.82 × 10 −3 LJP005 A549 24H-mitoxantrone-10 7/175 5.90 × 10 −4 5.03 × 10 −3 LJP006 HA1E 24H-mitoxantrone-0.04 6/127 6.13 × 10 −4 5.22 × 10 −3 LJP005 HS578T 3H-mitoxantrone-0.37 4/49 6.77 × 10 −4 5.68 × 10 −3 CPC020 A375 6H-mitoxantrone dihydrochloride-10.0 5/86 6.92 × 10 −4 5.79 × 10 −3 CPC005 HA1E 24H-mitoxantrone dihydrochloride-10.0 6/131 7.22 × 10 −4 6.02 × 10 −3 LJP005 MCF7 24H-mitoxantrone-3.33 6/131 7.22 × 10 −4 6.01 × 10 −3 LJP006 A375 24H-mitoxantrone-3.33 5/87 7.29 × 10 −4 6.06 × 10 −3 LJP006 A549 24H-mitoxantrone-10 7/183 7.69 × 10 −4 6.28 × 10 −3 LJP005 SKBR3 3H-mitoxantrone-3.33 4/55 1.05 × 10 −3 8.15 × 10 −3 LJP005 HS578T 24H-mitoxantrone-3.33 6/141 1.06 × 10 −3 8.20 × 10 −3 LJP006 HEPG2 24H-mitoxantrone-0.12 4/60 1.45 × 10 −3 1.06 × 10 −2 LJP006 HS578T 24H-mitoxantrone-0.12 4/60 1.45 × 10 −3 1.06 × 10 −2 CPC005 A375 24H-mitoxantrone dihydrochloride-10.0 7/209 1.66 × 10 −3 1.18 × 10 −2 LJP009 MCF7 24H-mitoxantrone-10 4/63 1.74 × 10 −3 1.23 × 10 −2 LJP008 MCF7 24H-mitoxantrone-10 4/63 1.74 × 10 −3 1.23 × 10 −2 LJP006 A375 24H-mitoxantrone-1.11 5/107 1.84 × 10 −3 1.29 × 10 −2 CPC005 PC3 24H-mitoxantrone dihydrochloride-10.0 6/158 1.89 × 10 −3 1.32 × 10 −2 LJP005 SKBR3 24H-mitoxantrone-0.04 4/65 1.96 × 10 −3 1.35 × 10 −2 LJP006 SKBR3 24H-mitoxantrone-10 5/109 2.00 × 10 −3 1.38 × 10 −2 LJP006 HT29 24H-mitoxantrone-3.33 6/167 2.50 × 10 −3 1.66 × 10 −2 LJP005 BT20 24H-mitoxantrone-10 4/70 2.57 × 10 −3 1.70 × 10 −2 CPD001 PC3 24H-mitoxantrone dihydrochloride-10.0 6/169 2.65 × 10 −3 1.74 × 10 −2 LJP005 A549 24H-mitoxantrone-1.11 5/117 2.72 × 10 −3 1.78 × 10 −2 LJP006 LNCAP 24H-mitoxantrone-0.04 4/72 2.84 × 10 −3 1.85 × 10 −2 LJP006 HEPG2 24H-mitoxantrone-10 6/172 2.90 × 10 −3 1.87 × 10 −2 LJP006 HME1 3H-mitoxantrone-0.37 3/36 3.11 × 10 −3 1.98 × 10 −2