J o u r n a l P r e -p r o o f 
This work was not funded by any organization.
All the authors declare that they do not have any potential or actual conflicts of interest including financial or personal relationships with persons or organizations that could have inappropriately influenced (biased) the study. No study sponsor was involved in designing or conceptualizing the study, in collecting, analyzing/interpreting the data, in drafting the manuscript or in the decision to submit the manuscript for publication.