COVID-19 has changed traveller numbers, destinations and patterns and the situation remains in constant flux. Travellers must comply with protective measures as considered appropriate by the country of departure, the country of arrival and the transporter, in particular airlines. There is confusion with regard to the risk of transmission of SARS-CoV-2. On one hand there is the risk of infection in-flight or at airports, which airlines address with measures such as the use of filters, monitoring and testing of passengers. On the other hand, governments try to limit the risk of transporting infectious passengers from abroad or within a country with measures such as travel bans and quarantines.
Despite large numbers of studies, there is still only scant evidence evaluating protective measures for air travel or indeed for everyday life. How useful are masks, hand sanitisers, thermo screening, pre-flight testing, seat distancing and air filtration systems respectively? Which measures are scientifically proven to have a benefit, and which are merely there to show that an effort is being made? There is a lack of unanimity throughout the world with respect to the definition of risk areas and thresholds for restricted travel as well as to the necessity, effectiveness, duration and implementation of quarantine measures. Airlines are struggling to be compliant with COVID-19 prevention guidelines while somehow retaining at least partial flight services. Travellers are struggling with the decision "Should I stay, or should I go?". This narrative review aims to assess the status quo of air travel measures as of October 2020 and to examine their scientific basis if appropriate.
As a group, we divided up topics related to air-travel in the pandemic period and did a rapid narrative review on each of the assigned sub-topics. For identification of relevant publications, a standardized search strategy was used. The PubMed, Scopus and Web of Sciences databases were searched by using the search terms "In-flight", "flight", "transmission"; "SARS-CoV-2", "airborne", "respiratory", "aviation", "COVID", "COVID-19", "Corona", "aircraft" in various combinations with the terms "cabin", "transmission", "social distancing", "quarantine" and testing". Additionally, cited publications in the original hits were screened and included if relevant, with no restrictions on language and years. IATA, flightradar24 and Forwardkeys were sources of information on air transport volumes. We checked official websites, did an airline survey by email or contacted airlines via social media to evaluate pre-flight and in-flight measures/precautions/recommendations adapted by airlines. . For 2020 IATA foresees a substantial reduction in numbers, with passenger departures projected at 2.2 billion (-51.6%), flights at 23 million (-40.6%) and RPKs at 3.9 trillion (-54.7%) (with 1749 km per passenger on average) [1] ,[ Table 1 ]. Data refers to international flights (between countries and territories) as well as domestic flights (within countries and territories). Based on mode of transport, 58% of international overnight visitors reached their destination by air in 2018 according to the World Tourism Organization (UNWTO) [2] . As for international travel, the vast majority of flights are within the same world region, rather than flights between regions.
Domestic air travel is rather concentrated in the large populous countries such as the US, China, India, Indonesia, Japan and Brazil.
Commercial flights (including cargo, but excluding private flights, some business jet flights, most helicopter, ambulance, military and drone flights) are tracked flights in virtual real-time by Flightradar24 and offers insight in flight evolution over time. The year 2020 started with growth in January in commercial flights. In February there was a moderate decrease because of the disruption of traffic within and to/from China. With the lockdowns increasingly being installed in many countries, flights were 55% down in the final week of March 2020 compared to the same period of 2019 [3] . In April 2020, flights were 74% below the same month in 2019, but showed early signs of a turning point at the very end of the month [4] . This slow recovery continued with flights down 71% in May [5] , 62% in June [6] , 50% in July [7] , 45% in August [8] , 43% in September and 42% in October 2020 [9] . At the height of the pandemic a majority of countries closed borders for inbound and/or outbound travel with traffic limited to repatriation of travellers and essential travel, or sometimes for all travel. In some cases, mandatory quarantine was ordered. Rising numbers at the end of August and throughout September have seen European countries adapt recommendations and restrictions with changes being implemented at short notice. At the start of October, at the time of writing, a second wave of COVID-19 is moving through Europe necessitating multiple travel restrictions. Domestic travel has been overall less restricted. The travel analytics company, Forwardkeys, based on its latest analysis, expects domestic air travel in China to have fully recovered by the start of September 2020. This is highly significant, because it is the first time, since the start of the COVID-19 outbreak, that a major segment of the aviation market, anywhere in the world, has returned to pre-pandemic levels [10] . The most resilient travel flows and the projected quickest to recover include the following [10] :
• Nearby destinations, domestic or neighboring countries • Late bookings and private transport • Visiting family, friends and relatives (VFR)
• Essential business travel, such as visiting clients, and providers. Meetings on the other hand are predicted to be held virtually when at all possible.
COVID-19 has changed how we travel; travel advisories and travel bans as well as quarantine or selfisolation when entering a country are now commonplace. For the international traveller, the variable and broad border measures now mean that they not only need to consider disease risk, but also need to take into account the need for quarantine at their destination, on their return, or both. Travel restrictions and quarantine are often the first response against emerging infectious disease threats [11] . They are used as public health tools to combat the international spread of COVID-19, although their utility is yet to be determined. The rationale for the implementation of quarantine is complex, based on a combination of factors such as economy, political agenda, and changing knowledge and epidemiology. Differing national and international guidance, evolving evidence, and the potential for recommendations to change rapidly make travel a lot more complex [ Table 2 ].
International travel advisories have been introduced, but where is the evidence that such bans are effective? While the direct effect of such advisories is difficult to quantify, travel advisories during the SARS epidemic in 2003 did result in a significant reduction in travel, but these were considered to be too late and too small to influence the global spread of SARS had there not been such effective control of the epidemics within affected areas [12] . Similarly, travel bans have been introduced in response to other emerging infectious disease threats, but the evidence relating to their impact has been inconsistent [13] . An analysis of the 2009 H1N1 pandemic showed that the decline in air travel to and from Mexico was too small to have an impact, and stricter restrictions would have led to delays of about two weeks even with early intervention [14] . Border closure were, however, shown to be effective in controlling the 1918-19 influenza pandemic in various Pacific islands [15] , and theoretically might be helpful in small island nations with low traveller numbers [16] , but a systematic review of the effectiveness of travel restrictions in containing the spread of influenza showed that in general, travel restrictions had only limited effect, and the degree of impact was dependant on multiple factors ranging from the extent and timing of the restrictions, the epidemic size, to virus transmissibility and travel patterns. The review concluded that only extensive travel restrictions had any meaningful effect on reducing the magnitude of epidemics, and on their own, might delay the spread and peak of pandemics by a few weeks or months but the evidence for containment of influenza within a defined geographical area was lacking [17] .
In the case of COVID-19, the evidence reveals a similar picture; some research has indicated a negligible effect of travel bans [18] , and other studies have suggested a delay in disease spread and case numbers, albeit with a recognition that complete travel bans are unlikely to be sustainable in the longer term [19] [20] . Yet, the current situation and patchwork of bans and quarantine measures is unprecedented in scale.
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Quarantine (the restriction of asymptomatic healthy people who may have had exposure to an infectious disease) after travel is one of the oldest public health tools known. Adopted widely in the fourteenth century to stop the spread of plague, quarantine has subsequently been used with varying degrees of success following international travel.
Following the 2003 SARS outbreak, an assortment of quarantine approaches was used in five severely affected countries/regions. While measures were highly effective in reducing onward transmission of SARS by containment of imported cases on arrival, implementation of quarantine was resource intensive, involved coordination of multiple sectors of society, frequently required new legislative actions or authorities, and was highly dependent on effective communication [21, 22] .
In the context of COVID-19, a Cochrane review found that quarantine is important in reducing incidence and mortality, and early implementation combined with other public health measures is important to ensure effectiveness. They also concluded that the quarantine of travellers from a country with a declared outbreak may delay its introduction or re-introduction, or may delay the peak of transmission, or both, but the effect was small, and their confidence in the results was low or very low due to the limitations in the evidence available [23] .
As of 3 rd September, an estimated 156 countries or territories have introduced some form of traveller quarantine measures [24] , and in the absence of any international consensus this means that approaches to quarantine and how it is implemented (voluntary/mandated, home/government facility, individual/group etc) will vary from country to country; likely based on a combination of factors, including epidemiology, culture, local context, economic imperatives and political factors. However, any decision to introduce quarantine measures is not without risk, requires adequate resourcing, and needs to account for the potential negative effects, which are increasingly being reported [25] .
As of October 9th, the Council of the European Union introduced a "traffic light system" based on infection rate per 100'000 people. The European Centre for Disease Prevention and Control (ECDC) will publish a map weekly categorizing EU regions into different zones for which different rules will apply. This is being complicated by countries being able to additionally set their own rules. A common testing regime has still not been set out making the framework difficult to work and further adding uncertainty to travel as nations are only required to provide information on new restrictions 24 hours before enforcement [26] .
COVID-19 has led to unprecedented lockdowns and reduction of air travel globally, fuelled by fear of trans-border introduction of the virus and onboard transmissions. The fear is not ungrounded as past instances with SARS-COV have shown that superspreader events can lead to hundreds of new infections. Transmission mainly occurs in the symptomatic phase of the illness [27, 28] . However, many infections in SARS-CoV-2 are also associated with contact to asymptomatic or presymptomatic patients [29, 30] .
In essence, flying will be safer and superspreading events diminished by optimizing screening procedures, minimizing the risk of allowing pre-or asymptomatic patients to board, and consequent implementation and adherence to simple hygiene measures that prevent the spread of diseases.
Various strategies have been introduced to detect SARS-CoV-2 carriers including temperature screenings, which is currently advised by IATA [31] . A recent paper has shown the lack of utility of temperature screening in the identification of young infected persons. Another option is demanding negative PCR tests before letting passengers board, a strategy Swiss Airlines is partly pursuing by allowing mask free travel with a medical certificate and a negative PCR test [32] . Certain destination countries also require a negative PCR test at point of entry [33] .
Simple measures, such as allowing only passengers to enter airports, regular disinfection of surfaces, and mandatory PPE for staff and handing out packs containing disinfectants and masks, have been introduced at various airports around the world [34] .
Temperature screenings have been introduced worldwide in an effort to reduce transmissions. The installation of thermoscanners can be quite costly. During the SARS pandemic, Canada spent around 5.7million dollars on the installation of such scanners, yet failed to detect a single case [35, 36] . Initial data speculated that only around 45% of travelers would be detected by temperature screenings [37] , recent data suggests that that number is much lower, as amongst young people a vast majority never develops fever [38] , suggesting that fever measurements are not an adequate screening method for airports.
There are three main ways to establish infection with SARS-CoV-2; nucleic acid tests to detect the presence of RNA, either via RT-PCR or LAMP. Antigen testing for the presence of a viral antigen, usually a surface protein. Antibody tests to detect prior infection using ELISA or LFA assays.
For diagnostic testing the gold standard currently is naso-/oropharyngeal swabbing with subsequent RT-qPCR analysis. The sensitivity varies greatly based on who performs the test and how it is being performed (only NP, OP+NP, only OP) in addition to viral RNA concentrations varying across the respiratory tract. A previous study in which both OP and NP specimen were collected in previously SARS-CoV-2 positively confirmed patients showed discordant results in 38% of the cases [39] .Due to the invasive nature of the test, prolonged positivity post recovery and variability of the results based on who performs them this makes it a poor tool for screening. The immune response against SARS-CoV-2 does not reflect infectivity of the individual, especially since in most cases the immediate IgM response is absent or not measurable [40] . , In addition commercial ELISA kits are costly and LFA assays lack the required sensitivity making them poor candidates for screening purposes.
The most promising candidates are thus antigen based testing and saliva tests.
Saliva tests have a similar sensitivity to PCR tests of 91% [41] , and most importantly are non-invasive and can be considered for self-testing. Colorimetric tests such as New England Biolabs tests seem especially promising as they allow testing with minimal amounts of equipment and results can be obtained within half an hour. Antigen tests such as Abbotts Rapid test are another option, as they provide immediate results and have a very high specificity. However, they still rely on nasopharyngeal swabbing [42] and have faced scrutiny in the past over low sensitivity of their tests [43] .
Recently, Finland and other countries are training dogs to detect SARS-CoV-2 positive patients. In a pilot study by Jendrny et al. tracheobronchial secretions and saliva were collected from positive hospitalized patients. The study was double blinded (dog, handler and observer) and the dogs were able to find positive samples with a sensitivity of 82% and specificity of 96.5% -most notably there was no significant difference between saliva and tracheal secretions (85% vs 87% hitrates). While the specificity of rapid COVID-19 Antigen tests is higher (99.5%), the sensitivity of dogs is much superior to those of antigen based tests (56.2%) [44, 45] . A limitation of the study is that only samples from hospitalized patients were used. A follow up study with samples from different time points of a patient is needed since especially pre-/ asymptomatic patients' samples are of interest. Nonetheless certain airports, such as the one in Helsinki [46] have already started using dogs to detect SARS-CoV-2 in travelers with satisfying results and a "sensitivity of almost 100%". As of October 10 th , more than 90 countries require arriving air passengers to be in possession of a negative COVID-19 PCR result from a test taken within a prescribed number of days prior to arriving in the respective country. The usefulness of this measure needs evaluation. More than 30 additional countries require a negative COVID-19 PCR test result to be exempt from quarantine or other restrictions. Although antigen testing may be more readily available, only PCR test results are accepted by these countries. More than 60 countries require COVID-19 testing upon arrival in the respective country, some regardless of whether the traveler already had a negative COVID-19 test result prior to arrival [47] .
In recent time, transmission of COVID-19 during airplane travel has gained enormous importance for reestablishing worldwide travel activities. Since air travellers spend extended periods in enclosed spaces where physical distancing is difficult or impossible, there is a theoretical risk of spread of infectious diseases during the flight. Although there is sparse knowledge on COVID-19, recent evidence is available for other (SARS-like) viruses and their dissemination during airplane travel. However, comparisons are difficult to make since the kinetics of viruses are different due to their size, aerosol-linked movement in the aircraft cabin as well as their infectivity. Recent studies in previous years have focused on other infectious diseases such as the Zika virus [48] , yellow fever [49] , the influenza virus [50, 51] , Ebola [52] , SARS [27, 53] , and others [54] but differences with COVID-19 precludes firm conclusions.
The cabin of a typical aircrafts [ Figure 1 ] is usually provided with a high airflow of many cubic meters per minute, which replaces the air onboard the cabin every two to three minutes. Air filtration in various implementations has become a critical intervention in managing the spread of COVID-19. Recent evidence has shown that severe acute respiratory syndrome (SARS-CoV-2) can remain airborne longer and travel farther than anticipated earlier in the COVID-19 pandemic, and high-efficiency particulate Air/Arrestance (HEPA) filters have been recommended [55] . In a typical aircraft, the recirculated air is passed through HEPA filters, which are required to remove over 99.97% of particles characterized by aero-diameter of 0.3 μm or larger [56] . In practice, however, they were found just as efficient at 0.01 μm, which is much smaller than the 0.125 μm size of the virus that causes COVID-19 [56, 57] . Altogether, high airflow and use of HEPA filters onboard planes make it unlikely to catch the virus from someone who is not in the immediate vicinity.
Social distancing during the whole time at an airport as well as during boarding, sitting and deboarding of the aircraft is of utmost importance to prevent the spread of SARS-CoV-2. Whereas the in-flight transmission of symptomatic COVID-19 patients is comparatively easy to identify due to clinical symptoms and is an established screening procedure [58, 59] , the evidence for the transmission of the virus from asymptomatic passengers on an aircraft is inconclusive. Only sparse data is available yet [60] .
In-flight transmission has been long-standing described for multiple infectious agents, especially bacterial and viral respiratory pathogens [61] , such as tuberculosis [62] [63] [64] , influenza [65, 66] , measles [67] , and other coronaviruses, such as the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) [27, 61, [68] [69] [70] [71] [72] .
During a flight from Singapore to Hangzhou International Airport in Zhejiang, China, in January 2020, a commercial aircraft carrying 335 passengers and crew members, 16 patients, not using face masks, were exposed and infected with SARS-CoV-2. The median age of those infected was 37 years, and no fatal outcomes were reported in these series, although 10 of these cases were symptomatic [73] . Two more instances of inflight transmissions were reported. One during a domestic flight between Sydney and Perth with 11 infectious cases during the flight. 6 were seated mid cabin and 5 aft cabin. They noticed a significantly greater risk of transmission in secondary infections in mid cabin vs aft cabin seats (11/112 vs 0/101 passengers) as well as window seats 7/28 vs non-window seats (4/83) [74] . The second flight was a long haul flight between London Heathrow, and Hanoi during which one primary case seated in business class led to 15 secondary infections. 12/15 passengers were seated in business class, 3/15 in economy class. The authors concluded that seating proximity (<2 seats away) was associated with the highest risk of transmission [75] .
Preliminary data from the U.S. Department of Defense using Boeing 777-200 and 767-300 air frames was released to shed light on aerosol behavior and virus reduction during a flight using mannequins. The study showed a minimum 99.7% reduction of virus aerosols. The authors concluded that the infection risk is thus 1 infection per 54 hours of flight and zero infections during a 12-hour flight. This contrasts the cases we described in this article in which several instances of inflight transmissions are reported. While the risk of transmission is probably low, such models are based on sitting mannequins and do not take into account human interactions, differences in airflow throughout the flight, possible infections during boarding or deboarding or even differences in seating arrangements during which infection risk also seems to differ. Further studies are necessary to evaluate elements in human behavior and heightened infection risk, as well as particularities and differences in airline safety protocols which could account for the differences in infection observed between flights [ Table 3 ]
As a consequence of the risk, the recommendation of face masks on board has been extended internationally during this period of transition from the pandemic to the peri-pandemic era. In a study of the repatriation of Israeli citizens from Japan, who had been passengers on the Diamond Princess cruise ship, no case of in-flight transmission of SARS-CoV-2 in the 14-hour flight was shown, likely due to use of face masks on board [76] . The risk of transmission of droplet-mediated infections on an aircraft depends on proximity to an index case and on other factors, such as movement of passengers and crew, fomites, and contact among passengers in the departure gate [68, 77] .
Considering the difficulty of airborne infection transmission in-flight because of HEPA filters used in aircraft ventilation systems, contact with contaminated surfaces or infected persons when boarding, moving, or disembarking from the aircraft may play a critical role in inflight transmission of infectious diseases [27] [61]. Whilst seated, Hoehl et al. characterised high risk only passengers seated within two rows of an index case [68] . Real-world data bodes well for flying too. Worldwide, there have been a few reports of individual transmissions linked to flights, but no superspreading-type events. Australia, through its exhaustive contact tracing system, did not identify any case of on-board transmission, even for people who travelled whilst contagious [78] . Bae and colleagues analysed 310 passengers who boarded an evacuation flight from Milan, Italy, to South Korea. N95 respirators were provided, and passengers were kept 2 m apart for physical/social distancing before boarding.
After an 11-hour flight, 299 asymptomatic passengers arrived in South Korea and were immediately quarantined for 2 weeks [79] . Only one passenger became infected after the flight [79] .
Barnett estimated the risk of catching the virus during a full 2-hour flight to be around 1 in 4,300.
The risk drops to 1 in 7,700 if airlines leave the middle seat empty [80] . This is further confirmed by recent data suggesting that following strict measures with the risk of infection with SARS-CoV-2 on flights remains extremely low (44 transmissions in 1.2 billion travellers). Even when taking underreporting into account, those figures are very promising.
The International Air Transport Association (IATA) supported wearing of face coverings for passengers and crew while on board aircraft, but did not support mandating social distancing measures that would leave 'middle seats' empty, based mainly on an economical argument. Airlines for Europe (A4E) stated that "leaving middle seats free (…) is not viable for the air transport industry given it would reduce the maximum number of passengers onboard to between 50-66 percent of aircraft capacity. Due to high operating and other fixed costs, airlines require planes to be at least 77 percent full in order to "break even."
The odds of dying of a case contracted in flight are estimated at between 1 in 400,000 to 1 in 600,000 depending on age and risk factors, which is comparable to the risk for a standard 2-hour exposure on the ground [80] . Finally, the risk of infection is also increased during travel to and from the airport, as public transportation and ridesharing can increase the risk of getting exposed to the virus [81] .
Mass gatherings (MGs) are watched cautiously by public health experts because of its three important public health implications [82] . First, MG related adverse health events and medical emergencies can compromise the public health response capacity of the host country. Second, MGs can accelerate disease outbreaks to epidemic levels in the host country. Third, MG related travel can accelerate the global seeding of pathogens with epidemic potential and may cause silent or explosive outbreaks globally. Air travel is particularly implied as a risk factor for the 2 nd and 3 rd outcome, and most notably for the 3 rd .
Increasing access to air travel is the most critical enabler of international mass gatherings such as the Hajj and the Olympics Games. However, air travel is also becoming increasingly relevant for other mostly domestic or regional MGs such as the Khumb Mela in India, Arbaeen in Iraq, and the Shiite pilgrimage to Qom in Iran. About three fourth of Olympics participants and Hajj pilgrims use air travel to reach their MG destination [82, 83] . It was in light of this fact that following the World Health Organization declaration of a public health emergency of international significance (PHEIC) on COVID-19, the authors advocated for the suspension of the of the year-around Umrah pilgrimage in Saudi Arabia, the trend setter for future MG cancellations [82] . Subsequent declaration of COVID-19 as a pandemic strengthened the call for the cancellation of MGs. MGs including the annual international Hajj pilgrimage, the Olympics Games 2020 in Japan, the Miami Beach Arts Fair, California's spring Coachella Valley Music and Arts Festival, and Canada's national music awards (the Junos) have been cancelled or postponed.
Due to airborne routes of disease transmission, respiratory diseases are the most common and consistent public health risk during mass gatherings [83] . When transmission occurs from innate surfaces and from human secretions, high density occupation in common spaces, high density crowding in event venues, and high frequency use of shared toilet facilities add to the complexity of transmission for both air travel and mass gatherings.
There is no known short-cut to hosting a true mass gathering amid a respiratory disease pandemic of high transmission potential, mortality, and poorly understood natural history such as COVID-19. During such uncertainties, the overwhelming public health recommendation have been to cancel the event [84, 85] .
Communities that held MG events prior to COVID-19 PHEIC such as the Qom pilgrimage in Iran and a conference in Boston have resulted in extensive COVID-19 transmission [86, 87] . Cases also increased to epidemic levels in areas that hosted multiple events as in the State of South Dakota in the USA. The scaled down Hajj2020 [88] with 1,000 domestic pilgrims in Mecca (1,200 square kms) do not meet the definition of a mass gathering (an event that strains the planning and response resources of the health system in the community where it takes place) as the downsizing afforded nearly 27 square meters of personal space to each pilgrim in the most potentially crowded pilgrim ritual area, the Grand Mosque.
As mitigation fatigue increases among the population, providers of travel health services will be faced with interest from their patients about participation in fly-in mass gatherings.
Attendance in religious MGs are highly sensitive events to many people and lifelong wishes of many, and interest in religious MGs may be amplified at times of uncertainty such as a pandemic.
However, in the absence of a vaccine or specific pharmaceutical intervention, participation in mass gathering during an active pandemic (with a respiratory virus that sustains among asymptomatic carriers) may not be encouraged. By providing a full list of implications of participation in MGs during respiratory disease pandemics (such as lock down for an extended period of time if exposed, challenges with medical evacuations if ill, the cost of evacuation for a pandemic disease acquired at a mass gathering), providers of travel health services can play an important role to help their patients to make informed decisions about MG attendance.
The success of modified air-travel amid a pandemic requires review of traveller compliance with prevention interventions, and ultimately of the utility of such interventions in reducing air-travel related risk of transmission. Participation compliance in individualized surveys or assessments is likely to be suboptimal in travel settings due to privacy issues, time factors, and crowded settings. One innovative epidemiologic surveillance approach has been the use of photepidemiology methods were systematically obtained sequential photographs of the crowd and analysed manually or using face recognition systems. Photo-epidemiology has its origins in wildlife surveillance, but Elachola & Ebrahim studied its utility to monitor face mask use for prevention of respiratory viruses and umbrella use for sun protection during the 2009 and 2013 Hajj mass gathering [89, 90] . Those reports remain as the first ever reported estimates of face mask and umbrella use during mass gatherings. Elachola and Ebrahim applied this method at airports for the first time early during the COVID-19 outbreak and reported face mask use among travellers observed at airports in Asia, Europe and USA [91] . At the height of COVID -19 lockdowns photo-epidemiology methods were also applied to monitor population face covering use in most frequented venues such as supermarkets [92] .The findings from these two studies generally corresponded to the disparities observed in implementation of face covering advisories, historic population exposure to face covering advisories.
The above experiences underscore the utility of photo-epidemiology to monitor face covering use among travellers. Photo-epidemiology studies can be tailored to specific flights as it can be conducted at departure lounges, arrival gates, and inside the cabin. Thus, photos taken at multiple points of a flight can also ascertain pre-boarding and post embarkation variation in face covering use, all of which affect airborne transmission of SARS-COV-2. While photo-epidemiology helps to address self-report bias of individualized surveys, this method may not be suitable for stratified analysis by age, gender and other characteristics of the surveyed population. Yet, photo-epidemiology remains the only available tool to measure population level prevalence of compliance of face coverings.
The crash of the Air India COVID-19 related repatriation flight carrying Indian emigrant workers from Dubai to Kozhikode airport on August 7, 2020 underscores how disease transmission risk from air travel could be compounded during pandemics. The 199 persons on board this flight had pre-flight COVID-19 negative tests but were exposed to rescue workers, security and government officials, and volunteers who rushed to the scene at the crash site. Given the COVID-19 status of the formal and informal responders were unknown and the airport was located in a high transmission area designated as 'hotspot', all rescued passengers and responders were quarantined and subjected to COVID-19 testing. The entire District Government Office, and airport emergency staff were quarantined, compromising the capacity of government and airport function in addition to adding to the COVID-19 response burden in the airport vicinity.
While the full extent of accident-attributable transmission primary and secondary transmission of SARS-COVI-2 is still being studied, the incident underscores the fragilities of risk aversion during air travel with implications for international assistance. Both airlines and airport management systems should have protocols in place that anticipate and prepare the ground staff for emergencies during pandemics. Plans should assure COVID-19 free status of all airport and responder staff, triage plans, a maintenance pool of vetted volunteers from the community oriented to disease mitigation concepts who could improve emergency response capacity, and surplus personal protection equipment in place. Advisories to travellers should include mention of emergencies including potential quarantine of survivors and such advance warning can help improve travellers' coping capabilities during an unanticipated crisis.
The International Air Transport Association sets forth rules for safe flying [93] . The implementation of said rules varies greatly based on the airline. While all airlines enforce masks on the flight, there are many differences in pre-flight and in-flight measures ( There are significant differences in pre-flight measures of airlines. Some, like the Lufthansa group or Emirates encourage or enforce pre-flight testing for their passengers. GoIndiGo on the other hand created an app that requires passengers to complete e questionnaires on their health status multiple times before the flight, which is essentially a telemedicine application.
Most airlines disinfect their plane before and after every flight. Some, like Aeroflot or the Emirates also disinfect sanitary facilities inflight during long flights. Air China varies the frequency based on an internal risk evaluation. Others, like Easyjet or Ryanair only seem to disinfect their flights once a day, claiming that this suffices for a full 24h.
A vast majority of airlines have reduced the food they are serving to prepackaged food or own food only. Turkish Airlines has a shift-based eating system only allowing certain groups of passengers to eat at once. All airlines seem to allow drinking during the flight, and all airlines enforce wearing a mask, or in the case of Aeroflot also gloves inflight.
All airlines we looked at are using HEPA filters. Some, like Turkish Airlines have especially designated isolation seats in case someone becomes symptomatic inflight.
There was little information available on which airlines use passenger locater forms, with some airlines such as Lufthansa stating openly that it is a data protection issue, and others such as Goindigo making it mandator via their app.
A report [98] report published by Faculty and Scientists at the Harvard T.H. Chan School of Public Health provides a comprehensive and thorough summary on common practices and recommendations concerning SARS-CoV-2 transmission during travel. They propose a layered approach for reduction of SARS-CoV-2 transmission (Education and Awareness; Screening; Physical and Engineering Controls; Process Management, and PPE) by means of NPIs (Non-Pharmaceutical Interventions) ( Figure 2 ) and suggests a reduction of risk to minimal levels can be achieved by utilizing standard control measures (social distancing, wearing masks, disinfecting of surfaces, screenings, testing and a strict enforcement of those measures) that are effective in other circumstances. Such an approach can mitigate the transmission risk of SARS-CoV-2 to passengers and crew members. We summarized those findings along with our recommendations in Figure 2 .
Our paper is a rapid, narrative review of the status quo (as of October 2020) of air-travel in the pandemic and peri-pandemic period. It is limited because it is not a systematic review and also because of the rapidly evolving numbers of publications that may have an impact on precautions related to air travel and SARS-CoV-2 transmission.
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In the pandemic and peri-pandemic periods, a substantial reduction in air travel numbers is apparent with a decrease (-51.6%) in passenger departures. Trends show that the most resilient and fastest travel flows for recovery are domestic flights and neighbouring country travel, last minute travel, visiting friends and relatives and essential business travel.
Systematic reviews show that in general, travel restrictions have only limited effect in containing infection, and the degree of impact depends on multiple factors ranging from the extent and timing of the restrictions, the epidemic size, to virus transmissibility and travel patterns. Quarantine of travellers from a country with a declared outbreak may delay introduction or reintroduction of the virus, or may delay the peak of transmission, or both, but the effect is small and there are limitations to the evidence available.
Temperature screening is ineffective. A combined approach of telemedicine (i.e. patients have to fill out self-assessment form prior to flight) and facilities at airports performing both systematic rapid tests, possibly a combination of saliva and antigen could be a viable future strategy at airports. Going forward, on arrival based saliva testing might thus be the best way to reduce the amount of people who have to quarantine after arrival. Hand hygiene and physical distancing from the point of entering an airport until leaving an airport as well as continuous face coverings are key elements of preventing SARS-CoV-2 transmission. Despite high air turnaround and high efficiency filtering used in aircrafts, there is some evidence that passengers within two rows of an index case are at higher risk. A retrospective analysis shows, however, that when stringent hygiene measures are enforced inflight, transmission rates of SARS-CoV-2 are likely to be very low as little as one case per 27 million travellers even with positive cases aboard. Guidelines from airlines are difficult to research. Most airlines disinfect their flights and enforce wearing masks and social distancing to a certain degree. Information on other precautions are lacking, not transparent and confusing to interpret. A layered approach of non-pharmaceutical interventions (including masks and sanitisers) for the entire journey (, home to airport to final destination) is indicated. While the guidelines set out by IATA are straight forward, a common platform for e.g. contact tracing, telemedicine approaches by e.g. preflight questionnaires and COVID-19 test results is lacking. What is necessary is a unified front with all stakeholders,, further validation of existing rapid tests and an expert committee to systematically evaluate preventive strategies so that recommendations for safe air-travel are evidence based. 