) .
H u a n  g  e  t  a  l  .  e  v  a  l  u  a  t  e  d  t  h  e  c  l  i  n  i  c  a  l  f  e  a  t  u  r  e  s  o  f  4  1  c  a  s  e  s  w  h  o  h  a  d  C  O  V  I  D  -1  9  i  n  f  e  c  t  i  o  n  ,  a  n  d  t  h  e  i  r  r  e  s  u  l  t  s  h  o  w  e r  r  e  n  t  l  y  ,  w  e  h  a  v  e  n  o  s  p  e  c  i  f  i  c  v  a  c  c  i  n  e  s  o  r  c  u  r  a  t  i  v  e  d  r  u  g  s  a  p  p  r  o  v  e  d  a  g  a  i  n  s  t  t  h  e  n  e  w  C  O  V  I  D  -1  9  i  n  f  e  c  t  i  o  n  ,  s  o  t  o   p  r  e  v  e  n  t  C  O  V  I  D  -1  9  i  n  f  e  c  t  i  o  n  ,  a  s  y  s  t  e  m  a  t  i  c  r  e  v  i  e  w  a  n  d  m  e  t  a  -a  n  a  l  y  s  i  s  h  a  s  b  e  e  n  c  o  n  d  u  c  t  e  d  o  n  a  s  t  u  d  y  o  f  t  h  e   p  r  e  v  a  l  e  n  c  e  o  f  c  o  m  m  o  n  c  o  m  o  r  b  i  d  i  t  i  e  s  b  y  a  n  a  l  y  s  i  s  o  f  c  l  i  n  i  c  a  l  r  i  s  k  f  a  c  t  o  r  s  r  e  s  o  u  r  c  e  f  o  r  C  O  V  I  D  -1  9  .   M  e  t  h  o  d  s   S  t  u  d  y  s  e  l  e  c  t  i  o  n   W  e  s  e  a  r  c  h  e  d  P  u  b  M  e  d  a  n  d  S  c  o  p  u  s  d  a  t  a  b  a  s  e  s  t  o  o  b  t  a  i  n  q  u  a  l  i  f  i  e  d  s  t  u  d  i  e  s  t  h  a  t  w  e  r  e  p  u  b  l  i  s  h  e  d  o  n  C  O  V  I  D  -1  9  u  n  t  i  l   M  a  y  1  ,  2  0  2  0  .  T  h  e  k  e  y  w  o  r  d  s  f  o  r  o  u  r  r  e  s  e  a  r  c  h  i  n  c  l  u  d  e  d  :  K  i  d  n  e  y  ,  C  O  V  I  D  ,  H  y  p  e  r  t  e  n  s  i  o  n  ,  D  i  a  b  e  t  e  s  ,  (  (  H  e  a  r  t  ) T  h  e  i  r  r  e  f  e  r  e  n  c  e  s  w  e  r  e  a  l  s  o  s  e  a  r  c  h  e  d  i  n  o  r  d  e  r  t  o  c  o  l  l  e  c  t  t  h  o  s  e  t  h  a  t  a  r  e  r  e  l  a  t  e  d  t  o   t  h  e  t  i  t  l  e  .   I  n  c  l  u  s  i  o  n  a  n  d  e  x  c  l  u  s  i  o  n  c  r  i  t  e  r  i  a   A  l  l  s  t  u  d  i  e  s  e  v  a  l  u  a  t  i  n  g  t  h  e  c  l  i  n  i  c  a  l  r  i  s  k  f  a  c  t  o  r  s  ,  u  n  d  e  r  l  y  i  n  g  d  i  s  e  a  s  e  s  a  n  d  c  o  m  o  r  b  i  d  i  t  i  e  s  o  f  C  O  V  I  D  -1  9  h  a  v  e  b  e  e  n   r  e  v  i  e  w  e  d  .  F  o  r  o  u  r  f  i  n  a  l  a  n  a  l  y  s  i  s  ,  t  h  e  s  t  u  d  i  e  s  s  e  l  e  c  t  e  d  s  h  o  u  l  d  r  e  p  o  r  t  d  a  t  a  o  n  t  h  e  p  r  e  v  a  l  e  n  c  e  o  f  e  a  c  h  o  f  t  h  e  r  i  s  k   f  a  c  t  o  r  s  f  o  r  t  h  e  s  e  v  e  r  i  t  y  o  f  C  O  V  I  D  -1  9  a  n  d  i  t  s  c  o  m  o  r  b  i  d  i  t  i  e  s  i  n  p  a  t  i  e  n  t  s  w  i  t  h  C  O  V  I  D  -1  9  i  n  f  e  c  t  i  o  n  ,  i  n  c  l  u  d  i  n  g   h  y  p  e  r  t  e  n  s  i  o  n  ,  c  h  r  o  n  i  c  k  i  d  n  e  y  d  i  s  e  a  s  e  ,  d  i  a  b  e  t  e  s  ,  c  a  r  d  i  o  v  a  s  c  u  l  a  r  a  n  d  c  e  r  e  b  r  o  v  a  s  c  u  l  a  r  d  i  s  e  a  s  e  s  ,  a  n  d  c  o  r  o  n  a  r  y All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020 . . https://doi.org/10.1101 /2020 h  e  a  r  t  d  i  s  e  a  s  e  .  O  n  l  y  h  u  m  a  n  i  n  v  e  s  t  i  g  a  t  i  o  n  s  w  e  r  e  s  e  l  e  c  t  e  d  .  T  h  e  f  u  l  l  t  e  x  t  s  o  f  t  h  e  r  e  l  e  v  a  n  t  d  o  c  u  m  e  n  t  s  w  e  r  e   a  s  s  e  s  s  e  d  f  o  r  e  x  c  l  u  s  i  o  n  a  n  d  i  n  c  l  u  s  i  o  n  c  r  i  t  e  r  i  a  .  S  t  u  d  i  e  s  t  h  a  t  d  i  d  n  o  t  h  a  v  e  a  d  e  q  u  a  t  e  d  a  t  a  ,  n  o  n  -h  u  m  a  n  s  t  u  d  i  e  s  ,   d  u  p  l  i  c  a  t  e  p  u  b  l  i  c  a  t  i  o  n  s  a  n  d  n  o  n  -E  n  g  l  i  s  h  p  u  b  l  i  c  a  t  i  o  n  s  (  e  x  c  e  p  t  t  h  o  s  e  w  i  t  h  u  s  e  f  u  l  a  b  s  t  r  a  c  t  d  a  t  a  )  w  e  r  e  e  x  c  l  u  d  e  d  .   D  a  t  a  e  x  t  r  a  c  t  i  o  n   A  l  l  t  h  e  s  e  l  e  c  t  e  d  p  a  p  e  r  s  w  e  r  e  i  n  d  e  p  e  n  d  e  n  t  l  y  e  v  a  l  u  a  t  e  d  a  n  d  s  c  r  e  e  n  e  d  b  y  t  w  o  a  u (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . https://doi.org/10.1101/2020.06.11.20128835 doi: medRxiv preprint   T  h  i  s  m  e  t  a  -a  n  a  l  y  s  i  s  i  s  b  a  s  e  d  o  n  d  a  t  a  f  r  o  m  8  2  s  t  u  d  i  e  s  w  i  t  h  l  a  b  o  r  a  t  o  r  y  -c  o  n  f  i  r  m  e  d  S  A  R  S  -C  o  V  -2  .  T  h  e  s  e  l  e  c  t  e  d   s  t  u  d  i  e  s  w  e  r  e  f  r  o  m  a  l  l  o  v  e  r  t  h  e  w  o  r  l  d  n  o  t  a  s  p  e  c  i  f  i  c  r  e  g  i  o  n  .  B  a  s  e  d  o  n  p  r  e  v  i  o  u  s  r  e  s  e  a  r  c  h  e  s  o  n  S  A  R  S  -C  o  V  a  n  d   M  E  R  S  -C  o  V  ,  i  t  i  s  u  n  d  e  r  s  t  o  o  d  t  h  a  t  t  h  e  s  e  v  i  r  u  s  e  s  a  f  f  e  c  t  m  a  l  e  s  m  o  r  e  t  h  a  n  f  e  m  a  l  e  s  (  2  8  ,  2  9  ) . All rights reserved. No reuse allowed without permission.
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The copyright holder for this preprint this version posted June 12, 2020. . https://doi.org/10.1101/2020.06.11.20128835 doi: medRxiv preprint   I  n  s  u  m  m  a  r  y  ,  t  h  e  r  e  s  u  l  t  s  o  f  t  h  e  c  u  r  r  e  n  t  r  e  v  i  e  w  i  n  d  i  c  a  t  e  d  t  h  a  t  i  n  C  O  V  I  D  -1  9  p  a  t  i  e  n  t  s  ,  d  i  a  b  e  t  e  s  ,  h  y  p  e  r  t  e  n  s  i  o  n  ,   c  a  r  d  i  o  v  a  s  c  u  l  a  r  d  i  s  e  a  s  e  ,  a  n  d  c  h  r  o  n  i  c  k  i  d  n  e  y  d  i  s  e  a  s  e  a  r  e  t  h  e  m  o  s  t  c  o  m  m  o  n  c  o  m  o  r  b  i  d  i  t  i  e  s  a  n  d  f  e  v  e  r  ,  d  i  a  r  r  h  e All rights reserved. No reuse allowed without permission.
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The copyright holder for this preprint this version posted June 12, 2020. All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . e  t  a  l  .  C  l  i  n  i  c  a  l  c  h  a  r  a  c  t  e  r  i  s  t  i  c  s  o  f  c  o  r  o  n  a  v  i  r  u  s  d  i  s  e  a  s  e  2  0  1  9  i  n  C  h  i  n  a  .  N  e  w  E  n  g  l  a  n  d  j  o  u  r  n  a  l  o  f  m  e  d  i  c  i  n  e  .  2  0  2  0  .  1  2  .  W  a  n  g  D  ,  H  u  B  ,  H  u  C  ,  Z  h  u  F  ,  L  i  u  X  ,  Z  h  a  n  g  J  ,  e  t  a  l  .  C  l  i  n  i  c  a  l  c  h  a  r  a  c  t  e  r  i  s  t  i  c  s  o  f  1  3  8  h  o  s  p  i  t  a  l  i  z  e  d  p  a  t  i  e  n  t  s  w  i  t  h  2  0  1  9  n  o  v  e  l  c  o  r  o  n  a  v  i  r  u  s  -i  n  f  e  c  t  e  d  p  n  e  u  m  o  n  i  a  i  n  W  u  h  a  n  ,  C  h  i  n  a  .  J  a  m  a  .  2  0  2  0  ;  3  2  3  (  1  1  ) : All rights reserved. No reuse allowed without permission.
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The copyright holder for this preprint this version posted June 12, 2020. . ,  Y  a  n  g  F  ,  X  i  a  n  g  L  ,  Z  h  u  J  ,  e  t  a  l  .  C  l  i  n  i  c  a  l  c  h  a  r  a  c  t  e  r  i  s  t  i  c  s  o  f  2  5  d  e  a  t  h  c  a  s  e  s  w  i  t  h  C  O  V  I  D  -1  9  :  a  r  e  t  r  o  s  p  e  c  t  i  v  e  r  e  v  i  e  w  o  f  m  e  d  i  c  a  l  r  e  c  o  r  d  s  i  n  a  s  i  n  g  l  e  m  e  d  i  c  a  l  c  e  n  t  e  r  ,  W  u  h  a  n  ,  C  h  i  n  a  .  I  n  t  e  r  n  a  t  i  o  n  a  l  J  o  u  r  n  a  l  o  f  I  n  f  e  c  t  i  o  u  s  D  i  s  e  a  s  e  s  .  2  0  2  0  .  3  3  .  R  o  d  r  i  g  u  e  z  -M  o  r  a  l  e  s  A  J  ,  C  a  r  d  o  n  a  -O  s  p  i  n  a  J  A  ,  G  u  t  i  é  r  r  e  z  -O  c  a  m  p  o  E  ,  V  i  l  l  a  m  i  z  a  r  -P  e  ñ  a  R  ,  H  o  l  g  u  i  n  -R  i  v  e  r  a  Y  ,  E  s  c  a  l  e  r  a  -A n t e z a n a J P , e t a l . . . . All rights reserved. No reuse allowed without permission.
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The copyright holder for this preprint this version posted June 12, 2020. . https://doi.org/10.1101/2020.06.11.20128835 doi: medRxiv preprint Y  a  n  g  Y  ,  Z  h  a  n  g  C  ,  H  u  a  n  g  F  ,  W  a  n  g  F  ,  Y  u  a  n  J  ,  e  t  a  l  .  C  l  i  n  i  c  a  l  a  n  d  b  i  o  c  h  e  m  i  c  a  l  i  n  d  e  x  e  s  f  r  o  m  2  0  1  9  -n  C  o  V  i  n  f  e  c  t  e  d  p  a  t  i  e  n  t  s  l  i  n  k  e  d  t  o  v  i  r  a  l  l  o  a  d  s  a  n  d  l  u  n  g  i  n  j  u  r  y  .  S  c  i  e  n  c  e  C  h  i  n  a  L  i  f  e  S  c  i  e  n  c  e  s  .  2  0  2  0  ;  6  3  (  3  )  :  3  6  4  -7  4  .  5  4  .  Z  h  a  n  g  M  Q  ,  W  a  n  g  X  H  ,  C  h  e  n  Y  L  ,  Z  h  a  o  K  L  ,  C  a  i  Y  Q  ,  A  n  C  L  ,  e  t  a  l  .  [  C  l  i  n  i  c  a  l  f  e  a  t  u  r  e  s  o  f  2  0  1  9  n  o  v  e  l  c  o  r  o  n  a  v  i  r  u  s  p  n  e  u  m  o  n  i  a  i  n  t  h  e  e  a  r  l  y  s  t  a  g  e  f  r  o  m  a  f  e  v  e  r  c  l  i  n  i  c  i  n  B  e  i  j  i  n  g  ]  .  Z  h  o  n  g  h  u  a  j  i  e  h  e  h  e  h  u  x  i  z  a  z  h  i  =  Z  h  o  n  g  h  u  a  j  i  e  h  e  h  e  h  u  x All rights reserved. No reuse allowed without permission.
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The copyright holder for this preprint this version posted June 12, 2020. . (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . 9 8
. M  e  n  g  Y  ,  W  u  P  ,  L  u  W  ,  L  i  u  K  ,  M  a  K  ,  H  u  a  n  g  L  ,  e  t  a  l  .  S  e  x  -s  p  e  c  i  f  i  c  c  l  i  n  i  c  a  l  c  h  a  r  a  c  t  e  r  i  s  t  i  c  s  a  n  d  p  r  o  g  n  o  s  i  s  o  f  c  o  r  o  n  a  v  i  r  u  s  d  i  s  e  a  s  e  -1  9  i  n  f  e  c  t  i  o  n  i  n  W  u  h  a  n  ,  C  h  i  n  a  :  A  r  e  t  r  o  s  p  e  c  t  i  v  e  s  t  u  d  y  o  f  1  6  8  s  e  v  e  r  e  p  a  t  i  e  n  t  s  .  P  L  o  S  p  a  t  h  o  g  e  n  s  .  2  0  2  0  ;  1  6  (  4  )  :  e  1  0  0  8  5  2  0  .  9  9  .  L  o  v  e  l  l  N  ,  M  a  d  d  o  c  k  s  M  ,  E  t  k  i  n  d  S  N  ,  T  a  y  l  o  r  K  ,  C  a  r  e  y  I  ,  V  o  r  a  V  ,  e  t  a  l  .  C  h  a  r  a  c  t  e  r  i  s  t  i  c  s  ,  s  y  m  p  t  o  m  m  a  n  a  g  e  m  e  n  t  a  n  d  o  u  t  c  o  m  e  s  o  f  1 All rights reserved. No reuse allowed without permission.
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(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . https://doi.org/10.1101/2020.06.11.20128835 doi: medRxiv preprint All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . https://doi.org/10. 1101 /2020 Highlights: •   T  h  e  m  o  s  t  p  r  e  v  a  l  e  n  t  r  i  s  k  f  a  c  t  o  r  s  a  m  o  n  g  p  a  t  i  e  n  t  s  w  i  t  h  C  O  V  I  D  -1  9  w  e  r  e  h  y  p  e  r  t  e  n  s  i  o  n  ,  d  i  a  b  e  t  e  s  ,   c  a  r  d  i  o  v  a  s  c  u  l  a  r  d  i  s  e  a  s  e  ,  a  n  d  c  h  r  o  n  i  c  k  i  d  n  e  y  d  i  s  e  a  s All rights reserved. No reuse allowed without permission.
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
The copyright holder for this preprint this version posted June 12, 2020. . https://doi.org/10. 1101 /2020 