COVID-19 is a recent outbreak occurred worldwide and created a colossal dysfunction of various activity all around the world [ Moreover, the biomarker isolation and sample preparation are much more comfortable in protein-based biomarker as compared to a nucleic acid or other biomarkers. In the current detection of COVID-19, which is RT-PCR required RNA isolation, purification and processing step, which increase the time of detection and cost of testing. We can locate out such biomarker through proteomics studies from COVID-19 infected patient and find out specific biomarker for COVID-19.
All around the worldwide several research groups are indulged in developing a rapid diagnostic technique for Covid-19 detection, as the current method RT-PCR is time-consuming and costly.
To begins, this scenario Qiu and his team develop a Dual-Functional Plasmonic Photothermal
Biosensors, in this, they used plasmonic photothermal (PPT) effect and localized surface plasmon resonance (LSPR) with the help of two-dimensional gold nanoislands (AuNIs) which they functionalized with complementary DNA receptors which can perform a sensitive detection of the selected sequences from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [8] . Though this sensor is fast and more accurate as compared to RT-PCR result, still it does not remove the obstacle of virus particles exposure. To improve the detection limit et al, recently
develop an immunosensor based on SARS-CoV-2 spike protein based on graphene sheet on FET based system, this sensor has a better limit of detection [9] . However, it lacks the specificity in longer terms if viral strain gets mutated and change its morphology. These are some of the recent development through different research group for the rapid detection of Covid-19 and their various parameters are listed in table 1. However, none of them approaches towards the development of non-invasive biosensor, which can be user friendly and cheaper.
Rapid and early diagnosis of any diseases is always a major concern for any country. Currently, the situation related to COVID-19 is enormous, as we do not have any rapid system for early and J o u r n a l P r e -p r o o f [7] . In this review article, we have listed out the significant biomarkers which were reported in various paper after the clinical studies in COVID-19 patients in china.
Biomarkers such as Serum amyloid A (SAA) which secreted in a more substantial amount in COVID-19 patient as compared to a healthy patient, Serum ferritin is also a considerable biomarkers from these studies which also shows a potential to detect specifically COVID-19 as there is difference between secretion range and cut off the range, furthermore biosensor based on this approach will be non-invasive that can be user friendly in use so that the need of highly qualified professional limit can be overcome, apart this others biomarkers which can also be considered are listed in table 2 with the secretion range in healthy patient and COVID-19
infected patient [5] . Lastly, there are some more studies which report some more biomarkers such as IL-10, IL-6 and IL-1beta [4] .
Journal Pre-proof
Considering the urgent need for rapid detection of COVID-19 the biomarkers based sensor can plays a pivotal role as it will reduce the time to detect, will be cost-effective, and also reduce the chance of virus transmission while diagnosis, we can look forward to the integration of biosensor 