; Figure 6A ). In addition, the expression of several essential roles in this 280 pathway (such as IFN-β 1, IFN-γ 1, IFN-γ 2, IFN-γ 3, STAT1 and STAT2 ) also 281 dramatically increased in human Calu-3 cells with SARS-Cov and SARS-Cov-2 282 infection ( Figure 5B ; Figure 6B ). Notably, the expression of JAk1, IL7 and IL12A was 283 also up-regulated in Calu-3 cells after infection, which is different from that in HAEs.
To better understand the relationship of these components, a schematic model of 