Dodecafluoropentane emulsion [NanO 2 TM , NuvOx Pharma (Tucson, AZ)] is one 78 such promising perfluorocarbon. The molecular characteristics of NanO 2, comprised of 79 2% weight/volume dodecafluoropentane emulsion (DDFPe)(9) make it highly effective at 80 oxygen delivery at extremely low doses,(10) and an ideal intravenous agent for O 2 delivery.
81 In this study, we aimed to evaluate the potential of NanO 2 to improve oxygenation in 82 conditions of low V/Q mismatch and high intrapulmonary shunt by using a preclinical 83 model of acute lung injury and measuring the difference in mean oxygen saturation after 84 injection of NanO 2 or saline and differences in BAL cell count and protein.
We used an established two-hit mouse model of acute lung injury for this