Coronavirus disease 2019 (COVID-19) is a global pandemic associated with significant pulmonary and systemic manifestations [1] . Current literature shows a large cohort of patients with COVID-19 pneumonia developing venous thromboembolism, including This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). pulmonary embolism [1] . We present the case of a 55-year-old man who presented with COVID-19 pneumonia, who was found to have a thrombus in transit by routine point of care ultrasound (POCUS).
A 55-year-old male was brought in by emergency medical services for altered mental status (AMS). At presentation, the patient complained of fever and chills. Meaningful history could not be obtained because of the altered mental status. He was noted to have a fever of 102.3-degree Fahrenheit, heart rate of 136 beats per minute, blood pressure was 153/74 mm Hg, respiratory rate was 32 cycles per minute, and he was saturating 92% on room air. Physical examination was significant for coarse bilateral breath sounds. Laboratory investigations are tabulated and revealed acute kidney injury (Table 1) . Three blood samples were negative for bacterial infection. Chest X ray revealed hazy bibasilar opacities consistent with multifocal pneumonia (Figure 1 ). Electrocardiogram (EKG) (Figure 2 ) revealed sinus tachycardia and inferior infarct. Computer tomography (CT) of the head did not reveal any intracranial pathology. Patient was diagnosed to have COVID-19 pneumonia and was started on azithromycin and hydroxychloroquine. The patient's mentation progressively worsened and was intubated on day 4 of hospitalization. A point of care ultrasound ( Figure 3 - Figure  4 ) on day 7 of hospitalization revealed thrombus in transit in the inferior vena cava and right atrium suggesting impending pulmonary embolism hence the patient was started on thrombolytic therapy and full dose anticoagulation with heparin drip. Subsequently, the patient went into an asystole, likely related to massive pulmonary embolism. Cardiopulmonary resuscitation was initiated according to the advanced cardiac life support (ACLS) protocol without success and the patient expired.
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 virus presents with predominantly pulmonary manifestations however various systemic manifestations characterized by thromboembolism have been reported and can be potentially fatal. [1] The pathophysiology of pulmonary disease in COVID-19 is an entity distinct from ARDS, characterized by an initial viral pneumonitis, profound hypoxia in the absence of hypercapnia, symmetric alveolar infiltrates, and a remarkable responsiveness to prone positioning. Sustained inflammatory response from the host is suspected to be responsible for disease complications and its high rate of mortality. [2] The so-called cytokine storm resulting from this dysregulated inflammatory response can have devastating downstream effects, including multiple organ failure and coagulation dysfunction. An autopsy case series by Fox SE, et al. [3] showed the presence of small firm thrombi in the peripheral parenchyma of the lungs.
The presence of thrombi and endothelial injury has been widely observed in various reports and studies regarding COVID-19 infection. [4, 5, 6] Thromboembolic events have been reported in SARS as well, suggesting similar mechanistic properties to COVID 19. [7, 8, 9] A prospective study done in Wuhan, China showed the incidence of VTE in patients with severe coronavirus pneumonia to be 25% (20/81). [10] Another study of COVID 19 pneumonia patients admitted to intensive care units showed the incidence of VTE to be 31%, with pulmonary embolism accounting for a significant majority of those VTE cases. 5 Several case reports also corroborate the presence of pulmonary embolism in the setting of COVID-19 pneumonia. [11] [12] [13] [14] These observations have led to the adoption of routine anticoagulation for critically ill patients with COVID-19 infection, mostly with low molecular weight heparin. [15, 16] To date, there are no clinical guidelines regarding the management of a thrombus in transit. [17, 18] It is associated with poor prognosis and mortality, as it manifests itself in the critically ill. [19] Both percutaneous and surgical approaches may be consider for extraction of such thrombus in transit [20] . However, our patient was too unstable for any of these considerations. The utilization of point of care ultrasound (POCUS) has gained traction as an adjunctive means of surveillance for the development of VTE in patients with COVID-19. [21] Despite CT angiography being the standard of care for pulmonary embolism, it poses the question of safely implementing the exam. At the very least, droplet precautions must be observed, and CT scan rooms must be thoroughly disinfected after each exam with a COVID positive patient as to minimize the risk of transmission. [22] 
COVID-19 has significant pulmonary and systemic manifestations, including the development of venous thromboembolic events. We present a case of a thrombus in transit in a critically ill patient with COVID-19 pneumonia, where the initial diagnosis was made with POCUS. As obtaining CT exams has been logistically difficult due the infectivity and transmissibility of COVID-19, we contend that POCUS may have a role in the detection of venous thromboembolic events. Chest X-ray showing hazy bibasilar opacities consistent with multifocal pneumonia 