plueme/wizJson huggingface dataset:
This research aims to develop the knowledge about problem situations, causes and guidelines for driving social change. at the goal of creating a supportive society do not abandon each other through a series of research on target groups, areas or issues by creating quality academic work can bring the results into action to solve the problems of vulnerable groups and develop an effective health system that responds to all people and to develop the potential of researchers and people working in complex and difficult-to-reach marginalized populations through the development of methodological knowledge A new kind of training focused on real-world operations. and connection Seek cooperation between partners, networks, both from higher education institutions in the country. and abroad Public organizations, government agencies, NGOs Driving social change by developing a management system for the Center of Excellence to be the center of academic work for vulnerable groups and is a center for disseminating various information by creating a public communication space to drive policy and research strategies for vulnerable groups that can be put into action. aiming to create a society that does not leave each other at various levels, both at the policy level and the area The results showed that Reviewing family knowledge for a database Knowledge and understanding of family conditions in the context of Thai society that are facing It is such a study that will lead to seeing the "family" in the dimensions and surrounding context. To support the drive to solve the problem of social vulnerability situation. and understanding technology issues in the future world There will be a connection with human beings in terms of rights. The fairness that will occur is different for many levels of people. While the study of access to health systems among vulnerable populations both children and adults It is a study of both the body of knowledge about the complexity of the problem of social inequality and related dimensions in economic, social and political aspects. It has been found that inaccessibility of public health services is an important factor that must be addressed in the mechanism of both in the system and outside the system The research hence contains summary and policy proposals, 1) Work should be developed in the dimension of knowledge development concerning the complexity of social inequality problems. both in terms of situations Causative factors and contextual conditions in various dimensions and levels, and solutions at both the operational level and the structural or policy level. 2) Developing the potential of workers is important Because it is a solution that leads to the development of people in the mechanism of work both in the system and outside. Ready to drive work that is difficult and complex effectively 3) Should create a prototype area to perform specific problems. Based on the knowledge developed and networking at all levels from policy to community which will lead to driving for change in the future.
This research aims to study families in Thai society from the historic to the modern period and take a look at policies, measures, mechanisms, and methods to strengthen the foundation of families and presents possible means to improve the healthy life of vulnerable families in Thai society through public debates with related parties and experts and revision of relevant documents. The research shows that 1) The vulnerable families, or the target group, are unprepared for the collective lifestyle as a family and other factors unrelated to age as individuals, regardless of their age, could face difficulties in having a family, 2) The target group lacks comprehension on a concept of family and how to conform with such kind of relationships and do not realize own’s duties to bring the family together as a whole, 3) People in charge lacks supportive system, tools, or methods to help them set goals or adapt to work together; each section works separately toward their specific goals without communication or cooperation, 4) The importance of family is neglected causing the family to be excluded from any development plans or national policies, 5) Without coordination, the gap of interpretations on ambiguous policies leads to unorganized work and demotivates unity. This research summarizes and presents the following policy proposals; 1) Family crisis can be solved with logic and vision expansive enough to help recognize family crisis as a systematic crisis caused by multiple factors and dimensions with complexity. It is the reflection on the mainstream development which emphasizes materialization exchanged with family failures, social regression, and moral decline. It is the development that destroys the mind, family, and society as it drives people to go out into fierce competition for materials and money. Resources are spent on “country development” while they should be used to expand the prosperity of children and families., 2) To solve the family crisis, it is essential to see the importance of families as a foundation of future sustainability and security of the society and the country. The health of families fluctuates with each and every government policy, especially economic, academic, social, and labor policies. Therefore, we should recognize the healthy life of families and children as an ultimate goal of the nation.
This research aims to develop a concept and basic framework for research regarding a topic of artificial intelligence technology, and health and social equity; and to propose research agendas in response to long-term research on the topic. Data were collected from documents and multi-disciplinary workshops. The documentary data provided a basis for development of a basic conceptual framework regarding artificial intelligence technology, and health and social equity. Subjected to further development based on data from the workshops, the framework was applicable to research agenda analysis. Three workshops were organized comprising a total of 27 experts from the fields of philosophy and ethics in technology, laws, sociology, environment and development, computer science, bio-medical engineering, bio-science, and bio-medical information technology. From the study, a framework was obtained for analyzing issues and research agendas regarding a topic of artificial intelligence technology, and health and social equity. The framework consists of general and management principles. The general principles include respect for human dignity, justice, non-maleficence, and beneficence. The management principles are connected to and serve implementation of the general principles. In addition, the data from the workshops were analyzed through the framework and synthesized to form agendas for long-term research. These agendas are (a) research on factors from human nature and culture influencing equity in digital technology and artificial intelligence; (b) development of citizens' competencies related to digital technology and artificial intelligence; and (c) development of frameworks for policy development and implementation to develop and apply artificial intelligence to promote health equity.
This research aims to develop the knowledge about problem situations, causes and guidelines for driving social change. at the goal of creating a supportive society do not abandon each other through a series of research on target groups, areas or issues by creating quality academic work can bring the results into action to solve the problems of vulnerable groups and develop an effective health system that responds to all people and to develop the potential of researchers and people working in complex and difficult-to-reach marginalized populations through the development of methodological knowledge A new kind of training focused on real-world operations. and connection Seek cooperation between partners, networks, both from higher education institutions in the country. and abroad Public organizations, government agencies, NGOs Driving social change by developing a management system for the Center of Excellence to be the center of academic work for vulnerable groups and is a center for disseminating various information by creating a public communication space to drive policy and research strategies for vulnerable groups that can be put into action. aiming to create a society that does not leave each other at various levels, both at the policy level and the area The results showed that Reviewing family knowledge for a database Knowledge and understanding of family conditions in the context of Thai society that are facing It is such a study that will lead to seeing the "family" in the dimensions and surrounding context. To support the drive to solve the problem of social vulnerability situation. and understanding technology issues in the future world There will be a connection with human beings in terms of rights. The fairness that will occur is different for many levels of people. While the study of access to health systems among vulnerable populations both children and adults It is a study of both the body of knowledge about the complexity of the problem of social inequality and related dimensions in economic, social and political aspects. It has been found that inaccessibility of public health services is an important factor that must be addressed in the mechanism of both In the system and outside the system The research hence contains summary and policy proposals, 1) Work should be developed in the dimension of knowledge development concerning the complexity of social inequality problems. both in terms of situations Causative factors and contextual conditions in various dimensions and levels, and solutions at both the operational level and the structural or policy level. 2) Developing the potential of workers is important Because it is a solution that leads to the development of people in the mechanism of work both in the system and outside. Ready to drive work that is difficult and complex effectively 3) Should create a prototype area to perform specific problems. Based on the knowledge developed and networking at all levels from policy to community which will lead to driving for change in the future.
Religious places are sacred places where people come to perform important religious activities according to their respect and faith. However, this gathering could increase the risk for the transmission of COVID-19 through the respiratory route. In this study, the participatory action research was done in 9 religious places, including Buddhism, Christianity, and Islam, in Mueang and Tha Sala Districts, Nakhon Si Thammarat Province. A total sample of 202 people (from 9 studied places and other extended religious places) was recruited. The results found that religious places changed the form of the prevention of the COVID-19 in different ways during the pandemic. However, measures that all religious places must implement and comply with are the VUCA (Vaccine, Universal Prevention, COVID Free Setting and ATK), DMHTTA (Distancing, Mask Wearing, Hand Washing, Temperature, Testing and Application Thaichana), and environmental health measures. Moreover, when considered in the context of each religion, the developed guideline will include practical recommendations for people in charge of religious places, priests, people, and important religious activities.
Chronic kidney disease is one of a major health problem both nationally and globally due to the tendency of the patient has been increased annually. At an early stage of chronic kidney disease, the patient has no symptom, but the diagnosis is possible by analyze an amount of microalbumin in urine and combine with serum creatinine. However, this process is allowed at the hospital only. To enable an effective and extensive access for a high-risk of chronic kidney disease population, this project focuses on using a urine microalbumin screening test kit for screening the chronic kidney disease at an early stage and including data storage in an online database for easily follow up and proper treatment planning. From the screening of a high-risk of chronic kidney disease population and asymptomatic at Ban Phaeo District in Samut Sakhon province, the 595 volunteers or 25.72% out of the 2,313 volunteers in total was suspected of chronic kidney disease. After 3 months follow-up, 178 patients (out of 260 volunteers) still had renal dysfunction that met the criteria for diagnosis of chronic kidney disease. The estimated prevalence of chronic kidney disease was 17.5%, which is similar to the prevalence in a general population from the Thai-SEEK project. The urine microalbumin screening test kit provides 96% accuracy, 86% sensitivity, and 98% specificity that indicated an efficient, highly accurate, convenient to use, and the results can be read rapidly. It can be used outside the laboratory which enable to reach high-risk populations. Moreover, it also possesses the potential for further commercial use.
Mycophenolic acid (MPA) is an immunosuppressant medication used to prevent rejection following organ transplantation and is under investigation for its efficacy against osteosarcoma. We investigated the genetic variability of whole-exome sequencing (WES) data from osteosarcoma patients and healthy volunteers who receive mycophenolate mofetil (MMF), a prodrug of MPA. Using the whole-exome sequencing (WES), we found 95 single nucleotide polymorphisms (SNPs) in osteosarcoma patients and 118 SNPs in healthy volunteers based on the list of genes related to MPA and its metabolite (MPAG) metabolism. For osteosarcoma patients, variants located in the gene UGT1A8, SLCO1B3, IMPDH1, ABCC3, UGT1A6, and UGT1A7 were related to some pharmacokinetic parameters of MPA and MPAG. For healthy volunteers, variants located in the gene SLCO1B3, SLCO1B1, and CYP2C8 were found to be in relation to some pharmacokinetic parameters of MPA and MPAG. In addition, we examined the effects of trimethoprim-sulfamethoxazole (TMP-SMX) on gut microbiota and the pharmacokinetics of MPA and MPAG when co-administered with MMF in healthy volunteers. The results have shown that TMP-SMX could alter the structure of the gut bacterial community. TMP-SMX treatment significantly decreased the relative abundance of genus Bacteroides, a major group of β-glucuronidase-producing bacteria in the gut. Moreover, concomitant administration of TMP-SMX with MMF also significantly reduced the area under the concentration-time curve from time 0 extrapolated to infinite time (AUC0-∞) of MPA. These results imply that TMP-SMX may interfere with the enterohepatic recirculation of MPA by decreasing gut bacterial β-glucuronidase enzymes that are responsible for regenerating MPA from its glucuronide metabolite MPAG, resulting in the reduction of MPA exposure.
This action research aims to develop systems and mechanisms for managing the coronavirus disease 2019 crisis in Ubon Ratchathani Province of district and sub-district departments. A tool used as a guideline for questions in group discussions. Data were analyzed using frequency, a percentage for quantitative data, and content analysis for qualitative data. The results revealed that district and sub-district departments established the cooperation system with guidelines. There are clear guidelines in the disease control manual. Infectious waste was properly management. There is a budget plan for the municipality and the sub-district administrative organization to prepare for disease control in the next year. It planned to use the budget from the Community Health Security Fund to be sufficient for disease control in the sub-district. Kham Krang sub-district created a local health Charter to strengthen the operation, as well as be ready to prepare for the crisis from another infectious disease. The results of this study can be used as a model for budget support from local government organizations, causing the preparation of budgets for disease control by including packaged in the strategic plan and supported by Community Health Security Fund. It can measure the success of the budget administration. They use information and information for learning, assessing, and improving the process of disbursing the fund budget to support the control and prevention of coronavirus disease 2019 continuously and sustainably.
Older people with dependency are those who have limitations in daily activities. It affects physical and mental ability, social participation, and the need for help caring for the family and the community. Descriptive research aims to study the context of integrated care for the dependent older people with community participation by community participation in preparation for the re-epidemic of the coronavirus disease 2019. In addition, develop policy proposals for integrated care for the older people with dependency on community participation in preparation for the re-emergence of the coronavirus disease 2019. They have selected random samples from 6 provinces across the country. According to the inclusion criteria, 440 households of primary caregivers assessed the functioning ability of the older people, primary caregivers, and 440 families involved in older people's care. There were 154 community dependencies. Data were collected from the tools tested for the content quality of the research tools. From 3 qualified health experts, the content accuracy was 0.91, and the confidence value (Reliability) Cronbach's alpha coefficient was 0.69. There were both quantitative and qualitative. The study results were based on the principle of "Trust, Stay at home, Keep distance" and perceptions of COVID-19, impacts, problems, obstacles, and the need for care. Results In terms of quality, there are four preventive principles in mind: "Trust, Self Care, Stay at Home, Keep Distance" and guidelines for preventing COVID-19 at the family level. The gathering data is expected to form the information for planning, operating, and organizing training to provide knowledge and training in caregiving skills. It refers to preparing guidelines for caring for the dependent older people with dependency conditions in the personnel health, social workers, local government organizations, and related agencies.
This participatory action research (PAR) aimed to 1) develop a participatory public policy for the prevention of coronavirus disease 2019 (COVID-19) in Muang District, Trang Province, and 2) monitor and evaluate the implementation of public policy. The target groups for collecting data were divided into 2 groups: qualitative data, consisting of 1) a group of scholars or people working in a government agency, 2) a group of executives of a local government organization, and 3) a group of 94 people or civil society groups, and quantitative data consisting of 384 people in the targeted areas. The research was divided into 3 phases, namely 1) the study of the situation of the problem, 2) the policy development and the policy trial, and 3) the public policy assessment together with the development of public policy driving processes for health. In this phase, there were 5 steps as follows: 1) Formation of policy issues, 2) Public policy formation, 3) Public policy decision making, 4) Implementation of public policy, and 5) Monitoring and public policy evaluation. The research was conducted between April 2021 – May 2022. The research instruments consisted of a group discussion guideline, in-depth interviews, questionnaires, observations, and learning exchange forums (lesson learned). The results showed that the first step was the formation of policy issues caused by the problem of disease outbreaks in the community with preventive actions control of outbreaks under a committee based on the incident command system and the Public Health Emergency Operation Center (PHEOC) together with community participation. The proposal from a group of scholars included an accelerated measure that covers the active case finding, treating infected people, vaccination, campaigning for people to follow universal prevention measures, as well as healing infected people’s minds. The local government organizations support public relations information, equipment, and utilities that were necessary for home and community quarantine. Measures done by the people's groups or civil society, were to create a safe area from COVID-1 9 (COVID Free Setting), focusing on important places, including restaurants, schools, hospitals, factories, hotels, and markets. Once the public policy has been formulated, then policy decisions have been made. The policy has been implemented in the communities. There was the monitoring and evaluation of the policy implementation. It was found that people have followed the measures at a high level (M=2.62, SD=0.28). They were satisfied with the public policy at a high level (M=8.30, SD=1.69), and their participation was at a high level (M=8.45, SD=1.57). The findings suggest that the development of participatory public policy in the prevention of coronavirus disease 2019 (COVID-19) in Muang District, Trang Province arose under the participation of government personnel, the private sector, and the people in communities. They have driven the public policy concretely.
Fungal pathogens in humans have now been increasingly reported worldwide. In addition, the most common pathogenic fungi that are resistant to standard antifungal agents, particularly azole group, are Candida albicans, Aspergillus fumigatus, and Scedosporium spp., causing the need to develop various antifungal drugs and pharmaceutical products to co-treat such infections. Several active antifungal compounds are obtained from medicinal plants and fungal metabolites known as fungal quorum-sensing molecules, which have been shown to inhibit the growth of another fungal species. One of the fungal quorum-sensing molecules is tryptophol. This study aimed to develop a topical product as tryptophol-containing emulgel for inhibiting the growth of Candida albicans, Aspergillus fumigatus, and Scedosporium species complex as Scedosporium apiospermum, which is the most reported cases of infections and deaths. The preliminary results showed the minimum inhibitory concentration (MIC) of tryptophol against three fungal species were 0.5, 1, and 2.5 mM, respectively, while the minimum fungicidal concentration (MFC) was 3, 6, and 6 mM, respectively. Tryptophol at the concentration of 6mM, which was the maximum inhibitory effect of the three fungal concentrations, was not found to induce toxicity in the fibroblast (HFF-1) cells and had no effect on the life cycle of the Caenorhabditis elegans worms. The results from the laboratory have led to the development of a prototype topical product as tryptophol-containing emulgel at a concentration of 6 mM. When examining the cosmeceutical properties, it was found that the properties were good according to the cosmeceutical standards. It is also stable in both accelerated testing and at room temperature. Tryptophol-containing emulgel was used to reduce the size of eumycetoma from S. apiospermum infection in rats with a significant reduction in the eumycetoma size after at least 14 days of treatment. Moreover, the prototype product had no stimulant effect in rats when tested histologically (40/40 animals), consistent with the results obtained in human volunteers, with no cream-induced irritation using closed patch test for 96 hours in 30/30 volunteers. The results showed that tryptophol-containing emulgel at a concentration of 6 mM was able to reduce the number of pathogenic fungi in humans Candida albicans and Aspergillus fumigatus (in vitro study), as well as to reduce eumycetoma size caused by S. apiospermum infections. Moreover, tryptophol-containing emulgel did not cause irritation in rats and in human volunteers. These laboratory results can be used as the basis knowledge for further application in clinical studies for the acquisition of co-treatments to treat mycoses or other skin pathogens.