This research project is a research and development design. The objectives of this study were to 1) assess the outcomes of patient care through home isolation 2) develop a health management system platform for disease prevention and risk management in Long COVID-19 syndromes for a cohort of 608 people in the community and 3) assess Health management system platform for disease prevention and risk management in Long COVID syndromes for a cohort of 608 people in the community. The population and sample included: multidisciplinary professions which was consisting of physicians, registered nurses, pharmacists, medical technicians, physical therapist and 26 District Health Board and 30 patients in group 608. Data were collected between 1st November 2022 and 30th June 2023. The research method consisted of four steps: 1) the collection stage. Problems 2) model building stage, 3) model development stage, and 4) validation stage. Data were collected from in-depth interviews and analyzed by content analysis. Software development was tested by connoisseurship and tested the software system from the users among the staff of the subdistrict health promotion hospital, Village Health volunteer and group 608. The results found that: 1) Outcomes of patient care under home isolation were 1) factors that delayed work; management, materials, and misunderstandings in communication and lack of awareness 2) the key factors to success during the quarantine period; joining together and help each other from all sectors, teamwork and the use of technology to coordinate. 2) The prototype of this platform, named “608 Prompt@Home” or “608 Prompt@Home”; consisted of seven functions for staff of sub-district health promotion hospitals; consisting of 1) Viewing map data via Dashboard 2) Viewing patient information 3) Receiving notification upon patient request 4) Consultation recording 5) Coordinating village Health volunteers to provide 608 group care 6) Live chat and 7) Viewing summary reports. There were three functions for Village Health Volunteer groups: 1) Viewing 608 patient information 2) Assessing 608 according to the standard assessment form received from the staff of the sub-district health promotion hospital and 3) Live chat. There were 608 functions for the 608 group; four functions consisted of 1) viewing public relations information and selfcare 2) Self-assessment and assessment form from sub-district health promoting hospitals 3) Making an appointment to see a doctor and 4) Live chat. 3) The results of the evaluation of the use of the System Usability Scale (SUS) platform showed that the test results of 608 Prompt@Home received the average SUS Score from all three groups as follows: 1) received an average score of 73.75 points. 2) Village Health Volunteer Group received an average score of 80.62 points, and 3) group 608 received an average score of 55.00 points. The average from all three groups was 69.71 points. The development of this prototype 608 prompt@Home has received significant recognition from the user in community. In addition, the design and development of the system is in line with the needs of users. Furthermore, the platform needed to develop to be able to cope with other epidemics and emerging diseases in the future.