The coronavirus 2019 epidemic has forced health workers to work harder and risk more health hazards. including having to experience stress and pressure from working in various fields which affects health condition and quality of work life. The health service system, the nursing professional is the main manpower and an important factor in providing health services to the people. While the shortage of registered nurses is an ongoing problem. this study. The objective of this research aimed to study the factors of persistence in the nursing profession. and develop policy proposals to promote professional persistence of registered nurses in Thailand. Collected data both qualitative research using in-depth interviews Semi-structured interview and group chat with executives at the policy level operational level hospital administrators 70 head nurses and professional nurses working in primary, secondary and tertiary health care units, collecting data in the central region, Bangkok, Nonthaburi, the eastern region, Chachoengsao, Chanthaburi, the north, Chiang Rai, Phitsanulok, the northeastern region, Khon Kaen, and the region. South, Songkhla, Krabi. The research was conducted for 6 months from September 2021 to May 2022. The reliability of the data was tested with a triangular test. Analyze data with content analysis As the results, from the literature review and research, it was found that the factors affecting nurses' persistence in their jobs and professions during the COVID-19 epidemic were experiences of quarantine. Bed management authority for COVID-19 having adequate protective equipment receiving infectious disease prevention training self awareness Low perceived risk of COVID-19, social support corporate commitment job satisfaction Low stress levels and burnout ability to adapt Recognizing professional benefits Growing up from the wounds of the heart lack of depression worry-free and the frequency and duration of appropriate patient care. From the data collection, it was found that the work of nurses in the situation of COVID-19 can be divided into 3 areas, namely, in the community, which performs an outbreak investigation, creating health knowledge for people in the community. Liaison with internal departments and outside the community Active case finding (ATF) work in the vaccination unit (vaccination Observing symptoms after vaccination First aid to patients with post-vaccination emergencies referral Advice on action after vaccination preparation of materials In some areas, nurses will act as administrators in the overall picture of vaccination. and mostly perform duties In field hospitals, these include tasks related to nursing care, such as nursing records, medication dispensing, health counseling. food and nutrition care; liaising with various departments; receiving and referring patients. Other immediate and in-service solutions include patient registration. epidemic investigation working in the vaccination unit. The study, it was found that the factors affecting the persistence of nurses in the situation of COVID-19 were financial burden. Extra money from working in the covid situation professional ties professional pride and self-esteem organizational ties colleague and teamwork participation of the team in the work and efficient management systems such as on-time compensation appropriate workload Support and empowerment from executives Executives have clear policies in management. The COVID situation is a learning opportunity. Create a network of work across professions. Integrated work between professions and see the benefits of being a public health worker, such as accessing information about disease obtaining certain rights, such as being in a pre-vaccinated group As for the factors that may cause nurses to decide to quit their jobs during the covid situation, is the employment situation such as being a civil servant. Employment and compensation for work inconsistent with the current situation Policy proposal. From studying the persistence in the profession of nurses, for example, the Ministry of Public Health should have a manpower management system. both in normal situations by adjusting the management of the professional nurse workforce structure to be in line with the context of areas such as urban areas, semi-urban areas, rural areas; or in emergency situations There should be preparation of nurses. Both in terms of professional and academic competence, practical skills, and should have a professional nursing workforce management plan in emergency situations. The period of the epidemic should plan and coordinate manpower management and acting (Skill-mixed) and there should be a rotation of manpower (Rotation) and the post-epidemic phase. Should enhance work power and create happiness at work. The creation of motivation in working Ministry of Health Career advancement and compensation should be reviewed in accordance with the work system. and current situation and should be encouraged and reviewed about entering higher positions of nurses should be adjusted to have more specialized types of expertise in other areas; Ministry of Health and Nursing Council Continuing education systems of nursing professions should be supplemented, for example nurses specializing in emergency crises. and the Ministry of Health There should be a hiring system and the management of professional nursing personnel in emergency situations, such as the retirement nurse employment system. and a co-payment management system between health service units under the Ministry of Public Health. with local government organizations and should consider the number of infection prevention nurses in the hospital.