The World Health Organization was announced that a major pandemic a health emergency in April 2020 due to the COVID-19 pandemic. This evidence was impacted many people to stress and anxiety. Self-care is important. For reducing interpersonal interactions, technology is now increasingly active. Objectives: To develop a web application that reduces stress and anxiety resulting from the effects of the COVID-19 pandemic. This web application was designed to (1) Assess satisfaction with the use of the application website. (2) Measure the levels of stress and anxiety, and coping mechanisms. (3) Compare the effects of using a website application with a positive thinking program on reducing anxiety. (4) Synthesizing people's self-help approaches to stress and anxiety from the COVID-19 pandemic. Methodologies: Phase I was a mixed - method research to analyze data from the web application (N = 400) collected in Pathum Thani province. The instruments were the satisfaction survey, GHQ-28 Tool, Anxiety questionnaires, Coping questionnaires, and Positive Thinking Program, with the web application usage. Phase II was a quasi-experimental research method. The sample (N = 80) was randomly selected from Phase I into the experimental group (N = 40) and control group (N = 40). The experimental group completed the 15-Positive Thinking Program exercises within 20 days. Data collection was conducted from February 2022 to April 2022. The data analysis used were descriptive statistics, percentages, frequencies, averages, standard deviations, t-test dependent, and t-test independent. The content analysis used Atlast.ti software to synthesizing people's self-help Results: The sample consisted of individuals of working age, 21-30 years old (23%), 41-50 years old (19%), and 31-40 years old (18.5%). The satisfaction of using the web application was evaluated in three parts, the most satisfaction with the benefits (x ̅ = 4.04, S.D. + 0.83). The satisfaction with design, and performance were x ̅ = 4.00, S.D. + 0.78 and x ̅ = 3.14, S.D. + 1.64 respectively. The stress levels were categorized as normal (86.3 %) and abnormal levels (13.8 %). The anxiety levels were categorized as high (4.5%), moderate (49%), and low (46.5%). The coping methods used by the sampled individuals were distractions (x ̅ = 2.72, S.D. + 0.61) and positive thinking (x ̅ = 2.70, S.D. + 0.61). As a result of using web applications to reduce anxiety, anxiety scores were found within the trial group before and after using web applications with positive thinking training programs. Statistically significant differences at .05 (= 3.47, S.D. + 0.29) and (= 3.18, S.D. + 0.17) respectively, and anxiety scores between the trial group and the control group after using web applications with positive thinking training programs differed statistically significantly at .05 (= 3.18, S.D. + 0.16) and (= 3.48, S.D. + 0.33) respectively. People's self-help approaches to stress and anxiety from the COVID-19 pandemic which can reduce stress and anxiety, including relaxing by watching movies, listening to music. Cooking, planting trees, living with nature, and adjusting ideas in a positive way. Self-defense in the form of prevention of direct infection and indirect were reducing to read news which causing anxiety, choose useful news, get enough rest. exercise, eat healthy foods, and other methods, such as using mindfulness to solve problems. Promoting mental health, acceptance, etc. On the other hand, Self-help practices that have been done but rarely effect to reduce stress and anxiety include not being able to adjust your mindset, trying to forget about stress but not being able to. can't stay focused or calm your mind and can't let go. too much news. not being able to avoid risky places because it is necessary to go to work and go about daily life.