plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Consequences and Enablers of the Selection of High-Cost Medicines to the National List of Essential Medicines Category E(2) 
abstract:The National List of Essential Medicines (NLEM) category E(2) was first announced in 2007 to be the drug
list for specific groups of patients to provide equitable access to high-cost medicines regardless of
health benefit schemes. The selection of medicines to the category E(2) was managed by the NLEM
subcommittee under the National Drug System Development Committee. Since 2007, the selection
process has been evolved leading to an increase number of medicines to the E(2) list. This study
aimed to describe the selection process of medicine to the NLEM category E(2), including responsible
organization, process, definition/selection criteria, outcomes, as well as barriers and enablers. A
qualitative approach was employed comprising document review and semi-structured interviews with
policymakers and stakeholders of the selection process. Data were analyzed using a content analysis
approach. The results revealed that the number of medicines in the NLEM category E(2) increased every
3 years according to the serving term of the committees, resulting in 32 medicines approved for treating
40 indications in 2018. Barriers to efficient work procedures were addressed as follows: 1) limited budget
and skilled workforces; 2) limited frequency of call for drug submission to the NLEM; and 3) different
interpretation of the definition and enlistment criteria of NLEM on category E(2). In addition, the present
study found that giving high priority to the selection of medicines to the category E(2) and reviewing
barriers, enablers of the selection processes of the subcommittee would lead to a more efficient
selection process. The present study recommends performance improvement plans through
organizational structure including recruiting highly skilled staff, improving work processes, and a
monitoring and evaluation system to achieve the efficient selection process.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Trends in Financial Management of the Hospital under the Office of the Permanent Secretary, Ministry of Public Health: A Qualitative Study 
abstract:The objectives of this study were to: 1) studying the causes and factors of success/loss, lack of financial liquidity of the hospitals management, and 2) proposing financial management guidelines for the hospitals. The sample comprised 8 financial managers, working at the health region level and ministerial level. Data collection were collected by in-depth interviews, using structured interview forms. Data analyses was carried out using content analysis. The results found 8 themes of causes and success factors in hospital financial management: 1) nationally, set aside 10 percent of the money for management 2) adaption 3) leadership 4) provide additional income, reduce expenses 5) accounting software 6) reduce labor costs and adopt information systems 7) e-bidding procurement system and 8) Planfin preparation. There were found 10 themes of causes and factors of financial management failure: 1) inadequate budget allocation 2) capitation 3) allocation of the universal health coverage scheme budget downturn 5) incapability of hospital administrators 6) lack of leadership 7) labor cost 8) material cost 9) incorrect accounting information system and 10) operating expenses do not meet the fiscal plan. The policy recommendations for financial management guidelines are as follows: financial administration should be more decentralized to health regions and provinces; changing the method of budget allocating by excluding salary from the health capitation; setting a sharing fund to help hospitals with problems; increasing budgets for health regions; joint management using virtual accounts; and increasing joint financial management within health regions.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Applying Google Sheet for Action Plan of Sirindhorn College of Public Health Chonburi 
abstract:Background & Rationale: The previous format of data collection to formulate an action plan had many problems and obstacles. While the features of Google Sheet as a tool in Google for Education on the cloud system are fascinating. The purpose of this research was to develop an application for importing budget plan data on projects for the preparation of the annual fiscal action plan of the Sirindhorn College of Public Health Chonburi for the faculty of Public Health and Allied Health Sciences. Methodology: The process of system development life cycle (SDLC) was applied in 6 steps. 1. Google Sheet application development meeting was first launched to the planning and strategy committee of the college administrators (planning). 2. Set the scope of the system in detail covering the system requirements in terms of access and security of the system and data management functions to allow the system to collect and export data (defining). 3. Detailed information of the program was analyzed to design the work order and verify data integrity at the system boundaries (designing). 4. Created the database in Google Sheet as designed in the action plans with HTML, CSS, and JavaScript languages (building). 5. Evaluated the usability and functions of the program to improve the program (testing). 6. Installed the program, created user manuals for hands-on training, trained and evaluated user satisfaction for the final improvement of the system (deployment). Result: The developed web application had user interfaces for data import, data processing, data storage, and result presentation. The program used the Google Apps Script language that needed no installation of servers and database systems to the server. However, users were able to access it and collaborate simultaneously at any location with Internet connection. The overall satisfaction rating was high (average 4.1) for the efficiency of using Google Sheet to deliver the action plan of the College. Conclusion: The Google Sheet made it easy to import data, update and edit project plan information to create an action plan for Sirindhorn College of Public Health Chonburi. The process was simple, suitable, reduced duplicate work, and done with the same database consistent with the digital policy of the Faculty of Public Health and Allied Health Sciences, Praboromarajchanok Institute.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: A Literature Review of Health Status and Agreements or Laws for Urban Refugees and Asylum Seekers 
abstract:The objective of this study was to review policies related to the health care and well-being of urban refugees and asylum seekers in Thailand (URAS). The qualitative approach was exercised. Data collection comprised a review of academic documents from both domestic and international sources, multi-lateral agreements or international covenants, and domestic laws related to human rights and health of URAS. The acquired data were analyzed by means of content analysis. The findings revealed that there were three main health issues faced by URASs in Thailand: (i) disease screening, (ii) mental health, and (iii) other health issues. In terms of international covenants, Thailand has not yet been a signatory of the 1951 Refugee Convention. However, in 2019, the Government endorsed the ‘Regulation of the Office of the Prime Minister: Screening Process for Aliens Entering the Kingdom of Thailand and Incapable of Returning to Their Home Country’. There have no tangible changes of healthcare policies for URASs after the Regulation was promulgated. The present study recommends that, the Regulation should be used to create a concrete set of committees to expedite the issuance of subordinate laws or orders that can be exercised at the local level. Moreover, there should be additional studies on the extent to which the Thai Government should become a party of the 1951 Refugee Convention and should withdraw a reservation to ratify Article 22 of the 1989 Convention on the Rights of the Child. A thorough investigation was recommended to estimate benefits and drawbacks of becoming a party of these international agreements.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Development of telepharmacy practice guideline in Thailand 
abstract:At present, The Pharmacy council has launched the notification on Guidelines for Telepharmacy, with some additional details required to be stated for the setting of continuous and efficient operating in telepharmacy, while conforming current changes of society and technology. This study aimed to conduct the standard of telepharmacy and guidelines for pharmaceutical care and to develop data architecture which supports and facilitates the operating of telepharmacy. This study was designed in accordance with development research, in which it was divided into 2 phases. The first phase, literature review was done from guideline/standard of practice of foreign references and acceptable standard transportation requirements which was primarily analyzed for the suitability in consistency of context. Team on synthesis research has drafted the guideline of telepharmacy and guidelines for pharmaceutical care. Summary of the guidelines was obtained according to the group discussions of stakeholders and opinions from pharmacists. In the second phase, the draft of data architecture for supporting the telepharmacy was conducted in accordance with information from phase I. Additional suggestions from stakeholders were obtained, prior to the summary of data architecture. Phase I study result provided the basic guideline for telepharmacy that was consisted of minimum dataset (composing of patients’ information, prescription, dispensing, pharmaceutical care service, and drug transportation); the basic guideline for telepharmacy (in which it contained 8 components i.e., location, customer service approach, information technology, transportation, etc.); and guidelines for pharmaceutical care (including prescription analysis and pre-dispensing for remote prescription, drug transportation, and remote counseling. The result of phase II study provided the draft of data architecture using HL7-FHIR for standard messaging and standardizing the database which contributes to the data exchange among organizations and leads further to better outcome in patient care. Finally, this study proposed the Pharmacy Council of Thailand to implement the guidelines, standard data set, and capacity building for community pharmacist on telepharmacy service.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Tuberculosis in schoolchildren 
abstract:Background: Thailand is among the 30 countries with high tuberculosis (TB) prevalence. Cases of TB in Secondary schools have been reported and aggregated adolescents in school are at risk of TB transmission. Children with latent TB may develop TB diseases later on. Nevertheless, studies of TB diseases and latent TB prevalence in schoolchildren in Thailand are scarce. Method: We did an observational cross-sectional study in Secondary school children grade 7-12 in a school in Bangkok and a school in another province of Thailand. We used the Symptoms scoring questionnaire developed by the Bureau of Tuberculosis and Chest radiography to screen for pulmonary TB to identify the TB prevalence. And we used tuberculin skin test (TST) at a 10 mm. cut-off to identify latent TB infection in grade 7 students. Also, 80 students were undergone QuantiFERON® TB Gold (QFT) blood test together with TST. Furthermore, we did a survey on knowledge, attitude, and practice (KAP) of TB in school among personnel of the 2 schools using a structured questionnaire. Results: A total of 1,005 from 5,113 students from 2 schools were enrolled, 496 from Nawaminthrachinuthit Bodindecha School in Bangkok and 509 from Chonburi Sukkhabot School in Chonburi province. Three hundred and fifty-four, 176, 154, 176, 141, and 153 students were from Grade 1, 2, 3, 4, 5, and 6 respectively. The mean age was 14.6±1.8 years. Forty-six and 21.8 percent had the household incomes of 20,000-40,000 and less than 20,000 Thai Baht per month. Twelve percent had the history of TB exposure in the past. The screening with Symptoms scoring questionnaire and chest radiography revealed no TB disease in this survey. Meanwhile, 270 first grade students were screened for latent TB and 13 were positive, resulted in latent TB prevalence of 4.8% (95% Confidence Interval (CI), 2.3-7.4%) Of them, none developed TB disease during the 1-year follow-up. The TST at 10 mm. cut-off had the sensitivity 50% (95% CI 6.8-98.2) and specificity 98.7 (95% CI, 92.9-100%) compared to QFT. Furthermore, the results of KAP survey among the school personnel showed lower percentage (11-39%) of correct answers to knowledge of TB symptoms in children, transmission, and prevention of TB in community. Most personnel had positive attitude to learn about TB and help students to receive treatment (78-99%). However, 55% tended to separate students with TB from others even the students already receiving treatment and 29% would not be a personal tutor for students with TB after the treatment. Conclusion: The prevalence of TB disease and latent TB in Thai school children is not high. The routine TB screening in Thailand may target other population groups with higher TB rate. However, the protocol for reporting and investigation should be put forward for schoolchildren who develop TB diseases along with school personnel education on TB transmission and prevention.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Efficacy, Safety and Pharmacokinetics of Dolutegravir 50 mg once daily with food versus Dolutegravir 50 mg twice daily in HIV/TB co-infected patients receiving rifampin based antituberculosis therapy (1st Year) 
abstract:Concurrent use of rifampicin (RIF) and dolutegravir (DTG) reduces DTG exposure, thus, DTG 50 mg twice-daily is currently recommended. Food increased DTG concentrations in healthy volunteers by 33 – 66%. We therefore investigated the effect of RIF on DTG exposure when dosed at 50 mg once daily with food, which would be more convenient than 50 mg twice daily in resource limited settings, where generic fixed dosed combination of TDF/ 3TC/DTG (TLD) is widely available. Method: We conducted a single-center, randomized control trial study in Bangkok, Thailand to evaluate efficacy, safety and pharmacokinetics of dolutegravir 50 mg once daily with food versus dolutegravir 50 mg twice daily in HIV/TB co-infected patients receiving rifampin based antituberculosis therapy. TB/HIV coinfected adults, ART naïve, stable on RIF containing regimen for drug-susceptible TB were randomly assigned to receive DTG 50 mg OD with food (study arm; TLD 1 pill/day) or DTG 50 mg twice-daily (control arm; TLD 1 pill plus additional DTG). Intensive PK was scheduled at week 4. Blood samples were collected pre-dose, 1, 2, 4, 6, 8, 12, and 24-hour post-dose (by study arm). HIV-RNA, liver and renal function tests were monitored. DTG concentrations were determined by validated LC-MS/MS. PK parameters were estimated (nonparametric; WinNonLin). The primary endpoint was DTG geometric mean ratios (GMRs) of DTG 50 mg QD vs DTG 50 mg BID (90%CI) and percent of participants with DTG minimum concentrations (Cmin) above the required protein-adjusted 90% inhibitory concentration (IC90) of 0.064 μg/mL. Results: Totally 20 study arm and 20 control arm participants completed PK analysis. The majority were male (87.5%); with median age 35.6 years, and median body weight 57.5 kg. At baseline, median CD4 was 170 (IQR 45.5-302) cells/μL and median HIV RNA was 4.96 (IQR 4.23-5.61) log10 copies/mL; 43% had HIV-RNA> 100,000 copies/mL. GMR (90%CI) maximum concentration (Cmax) and area under curve (AUC0-τ) not within the bioequivalence range of 0.8-1.25: 0.84 (0.57-1.25) and 1.07 (0.72-1.59), respectively (Table 1). Cmin GMR was 0.3 (0.18-0.49); however, the geometric means in both arms were above the required IC90: 0.18 (0.11-0.28) in study arm and 0.59 (0.44-0.79) in control arm. At week 12, 83% and 83% of participants in study arm and control arm, respectively had HIV-RNA <50 copies/mL. At week 24, 83% and 100% of participants in study arm and control arm, respectively had HIV-RNA <50 copies/mL Both arms were well-tolerated. Conclusion: Although there were substantial reductions in DTG concentrations when co-administered with RIF, Cmin levels were mostly above the protein-binding-adjusted IC90 of 0.064 μg/mL and majority of participants had high efficacy and >85% had VL suppression at week 12 and 24. Dolutegravir based ART can be used safely with rifampin based antituberculosis.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Urban Migrant Health Survey and Enhancing Private Sector Role in Migrant Health System Development 
abstract:Migration is a global phenomenon. Thailand is currently the destination country with the largest population of migrant workers in ASEAN. Urbanization has attracted large numbers of migrants to cities and/or metropolis. Three main urban health challenges are infectious disease outbreaks due to overcrowded housing, chronic NCDs due to unhealthy urban lifestyle, and accidental injuries due to work risks. The Urban Migrant Health Survey and Enhancing Private Sector Role in Migrant Health System Development research project aims to develop the health service system that meet the health needs of migrant workers in urban areas, and promote the participation of private sector. The research methodology was a combination of quantitative and qualitative with documentary research. It consists of an assessment of migrant workers' health problems in Bangkok Metropolitan region, interviews, focus groups, and literature review. The data collection include face-to-face surveys from 432 migrant workers, 54 entrepreneurs and 81 health service providers, interviews with 20 migrant workers, 49 entrepreneurs, 3 health service providers, and 3 government officials, as well as 3 focus group meetings among expert and 2 future scenario meetings among entrepreneurs. Literature review emphasizes on six building block of migrant health system in developed countries and Bangkok Metropolitan. The documentary research findings are that the core idea underlying established migrant health system in developed countries is allocating migrant health rights according to their level of economic and social participation. Two major obstacles of migrant health system in Thai metropolis are the lack of migrant health policy in urban development policy and bias towards migrant workers in policy processes and health service provision. Therefore, it is necessary to tackle both by establish the share vision of an urban health system integrating migrant workers and promote the paradigm shift towards migrant workers integration as a participant in the urban economic and social development. In parallel, policies on proactive health service provision to cover dense urban migrant communities and health finance that covers all groups of migrant workers are introduced. These are supported by systematic management of migrant health database management system and enhancing the participation level of employers and migrants in the inclusive urban health system development.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Development of anti-PD-1 antibody for cancer immunotherapy 
abstract:Cancer is a major cause of death in Thailand. Apart from surgery, chemotherapy, radiation, and hormonal therapy, cancer immunotherapy became the most promising treatment in the era. Immune checkpoint inhibitors (ICIs) act as immune stimulators to reactivate exhausted T cells to harness cancer cells. Programmed cell death protein 1 (PD-1) is the most potent immune checkpoint molecule, and PD-1-targeted ICIs have been approved by the U.S. FDA for cancer immunotherapy for over 30 indications. In Thailand, ICIs need to be imported for cancer treatment, and the cost of this drug is very expensive, and most cancer patients cannot access this kind of therapy. So, the development of this drug in our country is urgently needed to make it cheaper and increase the chance of patients to access the treatment. This study successfully developed a novel humanized anti-PD-1 monoclonal antibody (humanized anti-PD-1 CUSB1936) using mouse hybridoma technology and characterized its physicochemical and biological properties. The result showed that the humanized anti-PD-1 CUSB1936 could bind to PD-1 protein with high affinity in the sub-nanomolar range and neutralize the PD1/PD-L1 interaction with EC50 values 375.2 - 613.5 ng/mL. In addition, the anti-PD-1 CUSB1936 VH3+VL2 variant could induce T cell activation via IFN-gamma and IL-2 secretion in vitro better than the benchmark antibodies (Keytruda and Opdivo). Then, the anti-PD-1 CUSB1936 VH3+VL2 variant was transiently expressed using the Expi293 expression system. The purified anti-PD-1 CUSB1936 VH3+VL2 variant was then characterized and evaluated in vivo anti-tumor activity in MC38/hPD1 allograft mice model. The results exhibited that the anti-PD-1 CUSB1936 VH3+VL2 variant at 10 mg/kg could significantly inhibit tumor growth compared with IgG antibody control and showed similar antitumor efficacy compared with benchmark antibody. These findings prove that the anti-PD-1 CUSB1936 VH3+VL2 variant exhibits high anti-tumor efficiency and could be further developed as a novel PD-1 targeted ICI in Thailand.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: A literature review of health state utility values in Thai cancer patients 
abstract:Utility value is an important outcome for cost-utility analysis (CUA). The EQ-5D is used to elicit the utility values for economic analyses recommended by the Thai health technology assessment guideline. Therefore, this literature review was to establish the dataset of utility values for Thai patients with liver, lung, colorectal, breast, cervical, ovarian and hematologic cancers in various stages in Thailand.
This study reviewed all relevant studies by searching international databases such as PubMed and Scopus, and national databases including health intervention and technology assessment program (HITAP), health systems research institute (HSRI) and Thai LIS-Thailibrary integrated system (ThaiLIS) Study was included if 1) report utility values for Thai cancer patients and 2) identify the type of instruments used to elicit utility values. Moreover, quality scoring and assessment were performed for all included studies based on the adapted National Heart, Lung and Blood Institute guideline.
Of total 4,432 studies identified, 30 studies were included for literature review. Utility values were elicited from direct methods (Standard gamble; n=3 and mixed direct methods: Standard gamble, Time-trade off and Visual analog scale; n=1), indirect methods (n=14), mixed direct and indirect methods (n=3), mapping techniques (n=3), indirect method and retrieved from published papers (n=3) and unidentified methods (n=3). Within indirect methods, the EQ-5D questionnaire (n=17) was used in which the EQ-5D-3L (n=13) was the most frequently used. However, none of the included studies reported the psychometric performance of the instruments used to elicit the utility values.
This review establishes the dataset of utility values for Thai cancer patients with various stages. Both direct (SG, TTO and VAS) and indirect methods are used to elicit the utility values. The utility values decline in patients with metastatic stage (Stage IV) compared to the earlier-stage (Stage I-II). However, the utility values are mostly the result from chemotherapy or surgery for cancer treatment, so the utility values is directly uncomparable among the included studies. Therefore, further studies investigating the differences of utility values derived from direct and indirect methods among Thai patient cancers with various stages should be encouraged. Furthermore, the EQ-5D-5L with hybrid model should be used to elicit the utility values for economic analyses based on Thai health technology assessment guideline.