plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Genetic Variation Study of Obesity in Thai Patients: To Develop a Polygenic Risk Score for Clinical Risk Assessment and Personalized Medicinal Treatment 
abstract:Obesity has become one of the world's most serious public health issues. Because the causes of obesity are complex and multifactorial, new eras of research are opening for the effective control of obesity through gene and nutrition intake interactions. Individuals' obesity tendencies are thought to be determined by GWASs (genome-wide association studies), which leads to powerful discoveries relevant to population health. Over 300 Thai obesity participants in the Siriraj Genomic Thailand cohort to conduct a GWAS on obesity-related variables such as BMI, body composition, blood clinical profile, and dietary intake. We examined 446,370 single-nucleotide polymorphisms (SNPs) and obesity trait associations, yielding 50 SNPs with significant obesity-associated traits. We discovered five SNPs (rs114330431, rs4964357, rs12190237, rs140552528, rs12103676, and rs4713103) that were associated with increased weight, BMI, waist circumference, and hip circumference (P 0.05). Seven SNPs have been linked to rising lipid profile levels, including rs4964357, rs12190237, rs117828572, rs142722966, rs9577364, and rs11779272. We discovered the effect of genetic variants on the risk of obesity-related comorbidities, including rs142722966, rs116845541, and rs2059238 have been associated with Diabetes and metabolic syndrome difficulties, while 6 SNPs have been linked to high blood pressure issues (rs79392564, rs12033263, rs79949466, rs77592423, rs6111497, and rs1597468). Linear regression analyses of dietary energy and macronutrient intakes with the SNP. The risk allele at rs4739762 and rs75047180 was associated with increased total fat (per allele effect: 18.06 g/d (95%IC 3.83-32.29, p= 0.013)), animal protein intake (per allele effect: 23.45 g (95%IC 10.69-36.22, p<0.001)), Vitamin A intake (per allele effect: 993.86 RAE (95%IC 454.68-1533.03, p<0.001) and Niacin intake (per allele effect: 5.24 mg (95%IC 1.39-9.09, p=0.008)). In conclusion, the obesity-related genetic loci identified here provide new insights into the genetic underpinnings of adiposity in the Thai population. This study adds to our understanding of the factors that contribute to obesity, which can help influence precision nutrition for obesity prevention and treatment.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Characterization of Bacteria and Saliva Proteome Specific to Periodontal Disease in Patients with Rare Genetic Immune Diseases (2021) 
abstract:Periodontal infections are common problem in general populations, particularly in patients with inborn errors of immunity (IEI). The disease is chronic and deliberating, resulting in reduced quality of life. Due to limited understanding of oral characteristics of the IEI patients, the aims of this project were to investigate genetic variants, phenotypes, plaque microbiome, and salivary proteome of IEI and periodontitis patients using exome/genome sequencing, metagenomic sequencing, mass spectrometry, and bioinformatics. Seventy participants: 15 IEI, 15 periodontitis, and 45 healthy were recruited. Seventy-five plaque DNA, 75 salivary samples, 75 metagenome data, and 75 proteomics data were obtained. This project showed that the IEI patients had poor oral hygiene and gingival inflammation. Genetic variants in BTK, CD40LG, FERMT3, STAT3, ELANE, TTC37, and NCF1, and chromosome 22q11.2 deletion were identified. The diseases diagnosed such as X-linked agammaglobulinemia, hyper-IgM syndrome, leukocyte adhesion deficiency, and congenital neutropenia. Metagenomics revealed that IEI patients had alterations in oral microbe composition, alpha-diversity, and beta-diversity. Bacterial species that were significantly increased in IEI: T. denticola, S. gordonii, S. oralis, Actinomyces, and V. parvula were pathogenic species also observed in periodontitis patients. Moreover, salivary proteins, particularly those related to bacterial defense, host immunity, and glycolysis, were significantly changed in IEI and periodontitis patients. In summary, this project demonstrates IEI-causing variants, microbiome dysbiosis, and disturbed salivary proteome in IEI and periodontitis patients. The study expands understanding of genotype and phenotype of IEI, leading to identification of biomarkers of periodontal diseases and impaired immunity. We provide genetic counselling and personalized oral care to the patients and families, publish international papers, groom researchers and students, build network, and distribute knowledge in international conferences and organizations. The project produces outputs/outcomes in academics, research, community, and health care that will lead to utilization of research in policy-making in the future.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Impact and Adaptability Through Behaviors Change for Prevention COVID-19 Among the Hill Tribe Populations Living in Borders Areas, Chiang Rai   Province, Thailand 
abstract:A cross-sectional study aimed to assess the impacts from the COVID-19 pandemic and adaptability to prevent and control the disease among the three groups (students, general population, and the elderly) of the hill tribe people lived in border areas in Chiang Rai province, Thailand. Validated questionnaires were used to gather information from participants. Data were collected between April 2021 and December 2021. A total of 2,208 participants were recruited into the study. Among students, their had got moderate level of the impact. Several barriers access education during the pandemic were detected such as inaccessible to internet and no educational technologies and materials available. The ability of their adaptations to follow COVID-19 prevention and control measures was found in moderate level. In general population, majority were impacted in moderate level. Several impacts were detected such as leaving job without compensation, salary reducing, not met the qualification from the national policy of compensation from the COVID-19 pandemic due to no Thai identification. Moreover, a large proportion had increased their family debt during the pandemic. The ability of their adaptations to follow COVID-19 prevention and control measures was found in moderate level. The elderly, a large proportion were working in agricultural section, and had got the impact in moderate level in particular their job and income. The main problem was unable to sell their agricultural products. The ability of their adaptations to follow COVID-19 prevention and control measures was found in good level. National educational policy should be focused on educational materials and technologies supported to children and schools. Creating and seeking markets and supply chains for general population and the elderly should be urgently executing. Moreover, the policy related to support prolong living environmental under the COVID-19 pandemic is crucial particularly those who are living in poor education and economic status.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Evaluation of Capacities of Health Systems to Response the COVID-19 Epidemic in Border Area, Chiang Rai Province 
abstract:A cross-sectional study was conducted to assess the capacities of COVID-19 prevention and control among healthcare workers and health system under the Ministry of Public Health and Ministry of Interior located in the border areas in Chiang Rai Province: Mae Fah Luang, Mae Sai, Chiang Saen, Mae Chan, Mae Suai, Wiang Pa Pao, Muang, and Chiang Khong Districts. Data were collected by validated questionnaires between April and December 2021. A total of 906 people were recruited into the study. In the aspect of management: healthcare workers working under health institutes belonging to the Ministry of Public Health, local government and health volunteers did not clearly understand the process of work. In the aspect of manpower: healthcare workers under the Ministry of Public Health reported having worked longer hours compared to the period of pre-COVID-19 epidemic, and healthcare workers shortage. In the aspect of communication: line application was favored among government officers. Mobile phones were commonly used among people in a community. In the aspect of materials for the implementation: N-95, PPE and face shield were not sufficient for working among healthcare workers, while the community members reported that masks and alcohol were not enough for them. In the aspect of budgetary: almost all government officers reported that they had a big challenge in the requesting process. Some of the officers did not get the compensation and used their personal money for buying equipment. In the governance aspect: the overload assigned from their director was the major concern. In the aspect of the health system: communities had established several commitments and agreements among them to prevent and control the disease. Moreover, most people followed the agreements. People in a community have good practices to prevent and control COVID-19. Personal and health system capacity related to COVID-19 prevention and control developments are crucial especially to people who are living in border areas. The main focus on improving the capacities are deploying processes of work in crisis situations to make them confident and accurately follow the instructions; the government sector is required to support budget sufficient and medical related materials to healthcare workers. Distribution of essential information to people should be prepared in appropriate languages. Communication channel is also one of the critical points to improve the prevention and control measures in a community. Encouraging people in a community in creating their commitments and implementing them are also very important concerns for improving the effectiveness of disease control and prevention.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Evaluation of the Effectiveness on COVID-19 Prevention Measures in Educational Institutions Located Border Areas, Chiang Rai Province, Thailand 
abstract:A cross-sectional study was applied to assess the effectiveness of COVID-19 prevention and control measures in different kinds of schools (public schools, private schools, day care center, foreign language teaching schools, and religion teaching schools) located in border areas of Mae Fah Luang, Mae Chan, Mae Suai, Mae Sai, Muang, Wiang Pa Pao, and Chiang Saen Districts, Chiang rai Province. The study population were school directors, teachers, caregivers, students, and their parents. Validated questionnaires were used to collect data. Descriptive and inferential statistics were used to test the associations at the α = 0.05. A total of 2,240 participants were recruited into the study. Among 168 school directors, 50.50% were female, and working at the schools that belonged to the Office of the Basic Education Commission. Majority of teachers and caregivers were female (84.13%). While 66.18% of parents were female, and 21.75% were Akha. While 57.55% of students were female. 64.57% of primary schools and 64.29% of high schools were detected in the level of “pass but required improvement” according to the standard protocol of COVID-19 prevention and control measures which was able to operate their schools. While 78.29% of day care centers were detected in the level of “non-pass the safety level and could not operate their schools”. A large proportion of parents (97.43%), 93.81% of all primary schools, 92.86% of high schools followed the national COVID-19 prevention and control procedures to an excellent level. The size of day care centers and school, and types of administration departments were associated with the effectiveness of COVID-19 prevention and control of organization level significantly. Parents’ knowledge and practices related to disease control were associated with the effectiveness of COVID-19 prevention and control of organization level significantly. In implementation for COVID-19 prevention and control, it needs to focus on the size and their administration departments of schools including knowledge and practice in COVID-19 prevention and control of parents.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Hill Tribe Community Model Development for Preparedness and Response COVID-19 Epidemic, in the Border Area of Thailand-Myanmar 
abstract:A community participatory action research aimed to assess knowledge, attitudes, and practices to prevent COVID-19 among the hill tribe population living in border areas including the impacts of the COVID-19. The ultimate goal was to to develop a model for preparedness and response COVID-19epidemic in the area. A validity questionnaire and special training programs developed were used as the tools. A total of 2,518 people were recruited. A moderate level of knowledge and attitude were detected. While a good level of practice to prevent the disease was found. Students were impacted from the pandemic of the COVID-19 in several dimensions such as having to stop studying and having trouble with online learning. The employees were terminated, and their salaries. Many people had debt during the pandemic. Farmers could not sell their products. A large proportion did not get the compensation from the government due to lack of Thailand national identification card (ID card). After the training, it was found that knowledge and attitude towards COVID-19 prevention and control of the participants improved significantly. The villagers were transformed from knowledge and prevention skills from people who attended the training program. There were many approaches to transferring knowledge and skills to the villagers: village broadcast, small group discussion, and small group training. All people in the villages had a better knowledge and skills in COVID-19 prevention and control with evidence of regular hands washing, wearing a mask and social distancing. Disease prevention and control implementation should be collaborated among community leaders, village health volunteers and villagers to maximize the effectiveness and efficacy especially under the situation of travelling restriction.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: The Proposal-Based Policy Synthesis of Social Return on Investment (SROI) in Tackling the Coronavirus Disease 2019 (COVID-19) Pandemic under the District Health Board (DHB) 
abstract:“The Proposal-based Policy Synthesis of Social Return on Investment (SROI) in Tackling the Coronavirus Disease 2019 (COVID-19) Pandemic under the District Health Board (DHB)” aimed to analyze the social return on Society (Social Return On Investment: SROI) of coping with the COVID-19 epidemic situation under the District Health Board (DHB) and to synthesize stakeholder analysis for policy recommendation. There are 6 DHB studies, i.e. Na Thawi DHB, Songkhla province, Bang phli DHB, Samut Prakan province, Bang Bua Thong DHB, Nonthaburi province, Song Phi Nong DHB, Suphan Buri province, Khon Kaen Muaeng DHB, Khon Kaen province, and Mae Sai DHB, Chiang Rai province. This research, there is mixed method research using the Social Return on Investment (SROI) concept of the Coronavirus Disease 2019 Epidemic Management System under the District Health Board (DHB). The study process comprised quantitative, qualitative method and participatory action research methods, using documentary research, secondary data, focus group, in-depth interviews, and questionnaires. Moreover, we use social value, financial proxy, net present value (NPV), cost-benefit analysis, and SROI calculation using a discount rate government bond 3%. The result of SROI under the Covid-19 management system of the District Health Board (DHB): 6 Case Studies during 2020-2021 with discount rate government bond 3% showed the following results: 1) Song Phi Nong DHB, Suphan Buri province has SROI of 1.59 times meaning that every one baht invested in the management system of Covid-19 under Song Phi Nong DHB has generated social value of 1.59 baht 2) Mae Sai DHB, Chiang Rai province has SROI of 2.58 times meaning that every one baht invested in the management system of Covid-19 under Mae Sai DHB has generated social value of 2.58 baht 3) Na Thawi DHB, Song Khla province has SROI of 2.25 times meaning that every one baht invested in the management system of Covid-19 under Na Thawi DHB has generated social value of 2.25 baht 4) Khon Kaen Muaeng DHB, Khon Kaen province has SROI of 0.98 times meaning that every one baht invested in the management system of Covid-19 under Khon Kaen Muaeng DHB has generated social value of 0.98 baht 5) Bang Bua Thong DHB, Nonthaburi province has SROI of 13.59 times meaning that every one baht invested in the management system of Covid-19 under Bang Bua Thong DHB has generated social value of 13.59 baht 6) Bang Phli DHB, Samut Prakarn province has SROI of 13.39 times meaning that every one baht invested in the management system of Covid-19 under Bang Bua Thong DHB has generated social value of 13.39 baht, respectively.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Development of a Prototype of Virucidal Sticker (COVID GUARD) for Medical Application 
abstract:This research is continuous innovation and an effective additional protocol to reduce and control the COVID-19 pandemic by creating free COVID-19-surfaces and environments without the required routine cleaning process. A prototype of a clear “DSci sticker” has been coated with a solution of Ag-TiO2/WPU nanocomposite, which is a smart material that can generate active species with long-lasting property. Our sticker with virucidal efficacy of 99.99% against SARS-CoV-2 according to ISO 21702: 2019 standard has been developed. The ROS and Ag+ accumulate on the surface of virus particles and denature the viral proteins, offering broad action against unspecified targets (all virus proteins, not just the spike proteins), which could be helpful in all SARS-CoV-2 variants of concern. In addition, the cytotoxicity test was determined according to ISO 10993-5: 2009 standard to ensure that our sticker is safe and non-toxic to humans and animals (% cell viability >70%). To take this research into real practice, we tested antiviral efficiency against SARS-CoV-2 under the simulated practical conditions following ISO 21702: 2019. We mimicked a spreading of virus in air (coughing and sneezing) using a direct spraying model. The results showed that our sticker completely eradicated SARS-CoV-2. Our sticker is used for medical equipment with clear readability and labelling. It reduces risks of high-touch contaminated surfaces and its virucidal efficacy lasts for at least three months (≥99.90%). The prototype is prompted for Thai FDA registration of class 1 medical devices. Furthermore, a production process in this work can be scaled up for an industrial production.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Development of Policy Recommendations and Situation Analysis of Education Management, Health Promotion and Prevention for Primary School Children, and Family’s Well-Being During Covid-19 Pandemic in Thailand 
abstract:Since the year 2019 till present (2022), all countries around the world have confronted with the Covid-19 pandemic. The Government of each country has launched several public health measures in responsive to the changes of the Covid situation as well as its own country context. The main objectives of this study were to prevent the spread of the disease and to reduce the infected cases and deaths. Public health measures included social distancing, city lockdown, travel restriction, and closure of public service places, restaurants, or schools. Those measures could cause negative impacts in several sectors, such as economic, environmental, and educational sectors. The Covid impact on education was of het concern as education is the foundation of human capital development. It has been found that approximately 1.6 billion children and adolescents (more than 90% of the total learners) in 190 countries could not physically attend their schools for several months due to school closure. In addition, above 100 million teachers and school staff had been affected by the rapid closures of schools. School closures resulted in the dropouts of about 24 million students. During the pandemic, many countries had adopted the online education approach in order to k continue the study activities for children. This study aimed to investigate the education management and health promotion and prevention activities for primary school children during the Covid-19 pandemic, and to develop policy recommendations for improving the quality of primary school education management and health promotion and prevention activities for children and parents for better preparation and responsiveness given any outbreaks in the future.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: A Study of Adverse Events and Unsafety After Receiving Covid-19 Vaccine of Chronically Ill Patients and Elderly : Case Study of Ramathibodi Hospital, Bangkok, Thailand 
abstract:This cross-sectional research study aimed to study adverse events and unsafety after receiving types of Covid-19 vaccine. The sample of the study was people with sevem groups of chronic illnesses and older adults who received the Covid-19 vaccine from Ramathiodi Hospital, Bangkok. Purposive sampling was 1,254 cases. Data were collected by face-to-face interview, telephone, or online using the personal questionnaire and the Adverse Events questionnaire. Results showed that almost half of the participants received AstraZeneca+AstraZeneca of 48.79 %. Participants with chronic illnesses and older adults who received the different types of Covid-19 vaccine had the significant difference of adverse events both first dose (χ2=20.21, p<0.001), second dose (χ2=47.7, p<0.001), and the two-dose crossover vaccine (χ2=50.3, p<0.001). The participants who received the two-dose crossover vaccine of Astrazeneca+Pfizer/Moderna had the most adverse events of 67.7%. However, the two-dose from the same group vaccine of Sinovac/Sinopharm+Sinovac/Sinopharm reported only 28% of adverse events. People who were younger than 60 years old with chronic disease had a statistically significant difference in the greatest adverse events compared to healthy older adults with chronic disease who received both the first and second doses of the Covid-19 vaccine (χ2=24.36, p<0.001; χ2=18.31, p<0.001). In addition, Pfizer/Moderna reported the greatest adverse events of 17.4-38.7% such as local symptoms (pain, swelling, redness, hotness, itchy at the injection site), fever, and muscle pain. Moreover, twenty-two participants reported severe adverse events and need to receive first aid and visit the doctor. The results of this study suggested continuing the policy recommendations for vaccination by using the same type of vaccine Sinovac/Sinopharm or AstraZeneca. Using the cross-over type of vaccine is not recommended, especially, in-group of people who were less than 60 years old and had chronic illnesses to decrease adverse events and increase safety.