plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Cost-Utility Analysis of Polysomnography (PSG) for Diagnosis Obstructive Sleep Apnea in Thailand 
abstract:Background: Obstructive sleep apnea (OSA) was the most common sleep-related breathing disorder. The prevalence of OSA was 15.4 in males and 6.3 in females in Thai population. OSA increased risk of car incidence and cardiovascular diseases and reduced quality of life. Level 1 polysomnography (PSG) was a precision method of OSA diagnosis. To grade the severity of sleep apnea, the number of events per hour was reported as the apneahypopnea index (AHI). Continuous positive airway pressure (CPAP) was the most common treatment for obstructive sleep apnea in patients who do not need surgery. In Thailand, PSG and CPAP were expensive and only reimbursed through the Civil Servant Medical Benefit scheme (CSMBS). Objective: To evaluate the cost-utility analysis and budget impact analysis of OSA diagnosis and treatment by PSG and CPAP compared to standard care. Method: Decision tree model and Markov model were used to estimate total costs, life years (LYs) and quality adjusted life years (QALYs) in societal perspective and governmental perspective. Relevant costs were direct medical costs and direct non-medical costs. Health outcomes were LYs gained and QALYs gained. The results were presented the incremental cost effectiveness ratio (ICER) of PSG diagnosis and CPAP treatment compared to standard care. Uncertainty analysis was conducted by one-way sensitivity analysis and probabilistic sensitivity analysis. Results: Full-night PSG and Split night PSA and CPAP treatment were cost-effective in Thai context at 160,000 Baht per QALY compared to standard care. The ICERs of moderate to severe OSA and only severe OSA patients were 86,635 – 90,014 Baht per QALY for Full-night PSG and CPAP treatment and 85,733 - 88,877 for Split-night PSG and CPAP treatment. If the capacity of PSG diagnosis increased 30% per year, the 5 years budget impact of Full-night PSG and Split-night PSG were 2,204 – 3,730 million Baht and 2,084 – 3,631 million Baht respectively.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: miRNA Expression in Cholangiocarcinoma Patients 
abstract:Cholangiocarcinoma is a major public health in Thailand, especially in the northeastern region. Due to lack of early detection and poorly responsed of chemotherapeutic treatment, thus new biomarkers are urgently needed. MicroRNA/miRNA is an important genetic molecule that may function as either oncogenes or tumor suppressors. The current study aimed to identify the differential miRNA expression among serum of 50 CCA patients and 50 healthy subjects. The miRNA expression was measured by Nanostring technology. Four miRNA were found siginificantly increased expression in CCA patients; miR-320e, miR-223-3p, miR-122-5p and miR-302d-3p. These miRNA might be played a key role in oncogenesis. And three miRNA that decreased expression in CCA patients were miR-451a, miR-16-5p and miR-23a-3p. The role of these 3 miRNA might be involved with suppressed tumor growth. All these candidate miRNA might be further used as diagnosis markers or prognosis markers.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Food Industry Interference in Public Health Policy in Thailand: A Focus on Interference through Government Organization 
abstract:Food industry intentionally takes actions to protect its benefit through direct or indirect industrial interferences with the public policy makers. The interferences mediate via direct contact with relevant government staff. This study aimed to collect lessons learnt from the experiences of industrial interferences with the public policies from government staff, and to develop recommendations for appropriate interactions between government and the industry. This qualitative study applied 3 methods: 1) a review of the literature and related documents, 2) in-depth interviews with key informants, and 3) a Delphi survey. The present study found that Thai and multinational companies in food industry used same interference strategies, such as, written communication, direct contact with administrators and policy makers. However, multinational companies tended to more often refer to international trade regulations and rules as an important strategy that created arguments when the intervened health policy was implemented. Based on the corporate political activity (CPA), the strategies directly applied to government officials include 1) information and messaging, 2) constituency building, and 3) legal strategy. Recommendations from the present study are 1) transparency throughout the process of communication between government and industry, 2) citation of academic evidence, including the rules and regulations related to international trade in communication, 3) a clearly defined process of communication between government and industry.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Model Development Using Healthier Choice Nutrition Symbol for Promoting Health of Noodle Consumers in Mueang Lampang District 
abstract:The aims of this research and development were to 1) develop a model and 2) study the effectiveness of using the healthier choice nutrition symbol in noodle shops, Mueang Lampang district, Lampang province. The research process consisted of 4 steps: 1) analyze, assess needs by in-depth interview with relevant parties (R1). 2) Design and develop of a model by adjusting the noodle soup recipe using low sodium seasonings to replace the original seasonings (D1). 3) The experimental model consisted of guidelines for adjusting soup recipes, how to cook soup, measurement of sodium salt content in the soup, placement of healthier choice nutrition symbol seasonings in the shop (R2), then assessing knowledge, attitudes, and behaviors on healthier choice nutrition symbol and sodium salt content in noodle soup in the experiment group, assessing satisfaction on new noodle soup recipe with 16 purposively selected experiment samples. Data were collected by using a questionnaire and an in-depth interview. 4) The evaluations on knowledge, attitude, behavior, sodium content in soup and post-satisfaction were undertaken to improve the final optimal soup recipe (D2) using content analysis from group discussions. The results found that: step 1, noodle shop owners realized the need to reduce the use of sodium salt in soup. Step 2, developed new soup recipe using soy sauce containing potassium chloride to replace the original sodium salt. Cooking manual was developed as guidelines explaining new recipes, how to cook soup, measuring the amount of sodium salt and placement of extra seasonings in a noodle shop. Step 3, after serving new soup recipe, the noodle shop owners gained better knowledge, attitude and behavior, with reduced sodium consumption. They were satisfied at the highest level. Step 4: The evaluations revealed that the amount of sodium salt use decreased from the daily measurement. However, the present study was just a pilot scale with small sample size. The model should be extended to a larger population for more reliable results.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Thailand Environmental and Policy Level Physical Activity Interventions: A Critical Review 
abstract:Increasing physical activity brings various benefits, not only preventing premature mortality and saving health care expenditure from non-communicable diseases, but also strengthening social solidarity, reducing social inequity, and improving quality of life. Environmental and policy-level interventions for physical activity are promising population-level interventions, however, the number of studies on those interventions were limited in the lower- and middle-income countries. Therefore, this study aimed to assess the existing environmental and policy interventions in Thailand for the future direction of the intervention design and development. A systematic scoping review was conducted in the primary databases (PubMed, Scopus, and Web of Science) and domestic secondary databases. To gain more understanding of the local context, 77 provincial administrative organizations’ strategic plans were further retrieved and analyzed by using the critical interpretative synthesis method. From the systematic review, 11 out of 1,681 studies were included. The results found that evidence on the active environment and active policy physical activity interventions in Thailand were limited in number and diversity, and were rather in sports facilities than physical activity. Infrastructures and urban planning for active transport were seen as a significant facilitating element by adults, while recreational amenities were the most essential factor in improving the elderly’s quality of life. At the local level, only nine provinces out of 77 invested in bicycle pathways, and 16 provinces invested in green spaces, while 42 provinces focused on sports facilities. Policy communication and translation at the local level on a comprehensive concept of physical activity, a collaborative platform between the Ministry of Public Health and Ministry of Interior to provide physical activity implementation, public communication, and routine policy evaluation should be prioritized. Further studies on physical activity policy designs for specific age groups of people were recommended.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Treatment Patterns and Effectiveness of Tyrosine Kinase Inhibitors in Patients with Chronic Myeloid Leukemia: Evidence from a Real-World Data Analysis 
abstract:A retrospective cohort study using real-world data was conducted to analyze the treatment patterns of tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML), compared with the guideline for regulating drug use of the National List of Essential Medicine (NLEM) category E(2), with the purpose of determining the effectiveness of tyrosine kinase inhibitors in CML patients covered by Thailand’s universal coverage scheme and social security scheme. This study focused on the treatment patterns and effectiveness of imatinib, nilotinib, and dasatinib. Data were obtained from the reimbursement database of the NLEM category E(2) during fiscal year 2012-2018. Patients were followed up until death or the end of fiscal year 2019. Descriptive statistics and non-parametric test using Kaplan-Meier method were performed in the analysis. CML patients were divided into 3 groups based on their medical history until the time of death or last follow-up as follows; 1) patients who received imatinib only (group A), 2) patients who received first-line imatinib and second-line nilotinib (group B), and 3) patients who received first-line imatinib, second-line nilotinib, and third-line dasatinib (group C). Of 574 CML patients, there were 400, 113 and 61 CML patients in groups A, B and C, respectively. The majority of patients in each group were between the ages of 30 and 39 years old (34.2%, 36.3% and 29.5 %, respectively), with a median follow-up of 36.6, 50.7 and 47.6 months. Prior to the last follow-up or drug switching, the average daily dose of imatinib in group A, B and C was 444.3, 474.1 and 474.8 mg, respectively. Real-world effectiveness using survival analysis revealed 2-year survival rates at 84.3% (95%CI: 80.3-87.6%) for group A, 91.0% (95%CI: 83.9-95.1%) for group B and 85.2% (95%CI: 73.4-92.0%) for group C, with 5-year survival rates in each group were 83.2% (95%CI: 78.9-86.7%), 85.7% (95%CI: 76.7-91.4%), and 66.4% (95%CI: 52.3-77.2%), respectively. Average daily dose of imatinib prior to drug switching was not complied with the guideline, which recommended high-dose imatinib (600-800 mg/day). The 2-year survival rates were comparable across groups (log-rank p-value 0.295), while the 5-year survival rates in group A and B were significantly higher than in group C (log-rank p-value: group A vs. C; 0.016, group B vs. C; 0.004). However, the causes of non-adherence to the guideline could not be identified due to the lack of important clinical data including cytogenic/hematologic response, drug resistance, and occurrence of adverse drug events during the treatment of CML.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Rehabilitation Services Framework by the Disabled and their Family in Disability Services Centers for Intellectual Disability, Autism, and Learning Disability 
abstract:This study aimed to investigate rehabilitation services framework by the disabled and family for people with intellectual disabilities, autism and learning disabilities, and to study the feasibility of developing other necessary services for policy recommendations. Data were collected using the process of lessons learnt and the focus group discussions with service providers, people with disabilities and their families in 8 disability service centers. Then, analyzing data based on the framework, considering the care process of people with disabilities throughout their lives from birth to death and needs of people with disabilities for each age range. The ultimate outcomes were that people with disabilities could live to their full potential. The results showed that the disability services centers for intellectual disabilities and autism had similar service characteristics including family peer counseling, independent living skills and social skills training, respite care, job skills training and job coach, life stop service and family support. Obviously, there were unclearly services providing in the center of disability services for individuals with learning disability. However, lessons learned from experts, parents of people with learning disabilities and related organizations indicated that emphasis should be placed on learning skills both in school and out of school together with school buddy for teacher and family in order to increase learning skills and potentiality based on individuals’ condition. This services framework would lead to the establishment of standards for service provision in the disability services centers in the future, together with the adjustments in accordance with the guidelines for the development of service systems for the disabled in the disability services centers. It covered the issue of amending the rules and regulations related to the establishment of service centers, setting service standards, service provider development, financial support, and information system.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Crisis Management during the First Wave of COVID-19 Pandemic Situation 
abstract:The coronavirus disease (COVID-19) is a massive pandemic crisis occurring across Thailand and the world. It has entirely affected the health system responsiveness of Thailand. The purpose of this study was to examine the governance mechanism and management processes in response to the first wave of COVID-19 in Thailand in 2020. A retrospective document review was conducted by studying the government’s management during the COVID-19 situation between January and December 2020 via online resources and websites, and summarized our research team’s lessons learnt from direct participation in academic and strategic supports for the Operation Center of the Center for COVID-19 Situation Administration (OC-CCSA) as well as key informant interview in the stakeholders from government, private and civil society sectors. The results revealed that crisis management differed at each step. From the preparatory phase to the full outbreak response phase, the policies and measures were unidirectionally implemented as “one-size-fits-all”. During the continuous phase, regional and provincial decentralization has been used in order to align with local context to balance between health and economic outcomes.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Why Insured Persons under Social Security Act Article 40 Missed Paying Contribution: A Qualitative Study 
abstract:The present qualitative study aimed to explore and understand reasons why insured persons under Social Security Act Article 40 missed paying contribution. Two data collection methods were used. First, telephone interviews, data were collected from nine village labour volunteers and community-based social security network members for Article 40 and one insured person who had experiences with Article 33, 39, and 40. The informants were from Lamphun, Burriram, Khon Kaen, Bangkok, and Phuket. Second, online public comments related to Social Security Act Article 40 published during 2011-2021 were reviewed. The findings showed that reasons the insured persons under Article 40 missed contribution payment included: too complex procedures of benefit claim, less elderly lump sum than expected, unequal benefits compared to other insurance schemes, not knowing the consequences of missed contribution payment, not knowing what and how to do when having missed contribution payments, being unaware of contribution payment deadline, inconvenience with available contribution payment channels, and poverty. These findings suggest eliminating barriers and improving ease of claiming benefits, raising awareness of health risks and consequences of missing contribution payments on benefit claims, and developing out-reach communication for contribution payment alert system, and easy to access contribution payment methods in remote communities.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Proportion of Dental Specialists Task Performance in Ministry of Public Health Hospitals 
abstract:There are an increasing number of dental specialists in Thailand especially within the Ministry of Public Health (MOPH), but information about their tasks’ characteristics is not well understood. This cross-sectional descriptive study aimed to explore the task proportion of specialists in MOPH’s hospitals and the determinants of their performance in three dimensions; work factors, health facility environment, and administrative environment. The results show that, aside from specialized dental services, 95.5% of dental specialists still provided basic services, and 68.2 % of them had documentary and administrative activities as part of their routine. On average, dental specialists allocated their working time to basic, specialized service, documentary and administrative works at a proportion of 41%, 48% and 11%, respectively. Work factors that might influence the performance of dental specialists were: 65.9% of respondents reported an intra-organizational agreement, 40.9% pinpointed the overwhelming burden of basic treatments over advance procedures. 18.2% reported low number of patients wanting specialized care, and 15.9% reported a shortage of general practitioners compared to work burden. Regarding health facility environments; 4.6% of dental specialists indicated lack of equipment for their advanced skills, while 31.8% mentioned absence of clear guidelines and systems for consultation or referral within a provincial dental service network. Regarding administrative environments; 38.6% and 43.2% of dental specialists pointed to a lack of policy and monitoring systems that support specialized dental services at provincial and regional levels, respectively. In conclusion, dental specialists in MOPH were responsible for basic and specialized services at similarly high proportions (41% vs. 48%), with additional documentary and administrative works. There are still rooms for development in terms of equipment adequacy, consultation and referral guidelines, policy direction and monitoring system.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Lessons Learnt From an Implementation of 3-Healthcare Provider Team for Primary Care Policy for all Thai in 4 Provinces in Thailand 
abstract:3-Moh policy launched in 2020 aims that each family has three doctors at the community, health center (or Health Promoting Hospital) and hospitals (a district hospital and a provincial hospital/regional hospital). The three-doctor policy recognize three doctors at three levels. The first doctor or Moh#1 is a village health volunteer who provide health services at community level. The second doctor or Moh#2 is health workers of a health center or a sub-district health promoting hospital providing health services at Tumbon or sub-district level. The third doctor or Moh#3 is a family medicine at district or provincial hospital. working at district level. Furthermore, 3-Moh policy aims to strengthen primary care development in Thailand. This study aims to explore lesson-learned and implementation process of 3-Moh policy in 4 target provinces namely Kamphaeng Phet, Roi Et, Saraburi and Trung. These provinces have had outstanding primary care development and they target a full-area implementation of 3-Moh policy. Mixed method was employed to capture all information. To assess an understanding and satisfaction on this policy, a total of 644 self-administered questionnaires were completed by 597 respondents who are Moh#1 and47 respondents who are Moh#2 & 3. In-depth interview was conducted among 30 administrators at provincial, district and sub-district level, and 24 healthcare providers. The study demonstrated that 3-Moh policy notably fostered an achievement of Primary Care Act B.E. 2562. In term of quantity, these 4 provinces achieve the target on registration of health and care providers to population. However, the implementation of this policy is still far from achieving its goal in term of quality which consist of “recognition, familiarity, accessibility and trustworthy”. There are rooms for improvement to achieve the goals of this policy. Key enabling factors for success are an integration of primary care-related policies among departments at ministerial level, an establishment of primary care division at provincial health office for integrated implementation and systematical monitoring and evaluation and an increase number of family doctors which is considered as a bottleneck of this policy. In addition, key challenge in the future is decentralization of health centers to local governments which is considered to affect a relationship and implementing of this policy