plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2018 source: HSRI 
title: Prediction of pre-eclampsia in advanced age pregnant women by using uterine artery Doppler  combination with maternal serum fms-like tyrosine kinase (sflt-1) , placental growth factor ( PlGF)  and pregnancy- associated  plasma protein-A (PAPP-A) 
abstract:Objective To study the prediction of pre-eclampsia in advanced age pregnant women by using  of uterine artery Doppler combined with serum sflt-1,PlGF and PAPP-A. Method The prospective collective data study was conducted at antenatal care clinic Thammasat University Hospital. The pregnant women with age above 35 years old with  gestational age between 18-24 weeks were recruited. The clinical risk factors were recorded. Uterine artery Doppler was performed at the same time with measurement of  serum markers. The occurrence of pre-eclampsia and obstetrics outcomes were followed and recorded. All data was analyzed. Results The total enrolled pregnant women were 296. Only 276 pregnant women have  complete  information to analyze.  5.43 percent (15 pregnant women) had pre-eclampsia while 94.57 percent (261 pregnant women) had no pre-eclamptic symptoms. The baseline characteristics of both groups including age, body weight, body mass index, parity and history risk of pre-eclampsia were not statistically significant different. In pre-eclamptic group has higher percentage of  abnormal uterine artery Doppler compared to non pre-eclamptic group (26.67%, 4/15 vs 16.48%, 46/261) but no significant different (p= 0.31). The ratio of sflt-1/PlGF in pre-eclamptic group were higher than non pre-eclamptic group ( 8.60 +4.79 vs 8.09 + 5.24) but no statistically significant different (p= 0.71). MoM( Median of mean )  of PAPP-A in pre-eclamptic group was  less than  non pre-eclamptic group but there is also no statistically significant. The logistic model was generated to predict  the risk ratio of pre-eclampsia. The abnormal uterine artery Doppler has risk ratio (RR) 1.78, while the ratio of sflt-1/PlGF above 14 has RR  2.54. The MoM of PAPP-A less than 0.5 has RR  2.5 , respectively. Combination of these factors has prediction value for prediction 64.62%. Conclusion The combination of these factors could not be used  to predict the occurrence of preelcampsia in advance age pregnant women . However, the  incidence of preeclampsia in our study was lower than expectation , the larger sample size might be needed to verify this benefit.
location: nan, 'Thailand 
year: 2018 source: HSRI 
title: ภาระและระบบการดูแลโรคหลอดเลือดส่วนปลาย ต่อเนื่องปีที่ 3 
abstract:Objectives: Peripheral arterial disease (PAD) in diabetic patients is associated with high morbidity and mortality. The mortality rate in such patients is 56.5% in 3 years follow up period in Maharaj Nakorn Chiang Mai Hospital, Chiang Mai University. Therefore the incidence and predictive factors to determine the major adverse cardiovascular event (MACE), which composed of non-fatal myocardial infarction, non-fatal stroke, worsening PAD and death is of paramount important. Researchers aimed to explore these outcomes in our population. Method: 500 diabetic patients with being diagnosed as PAD between May 2014 to February 2017, were followed up in 30 months to determine MACE. The potential clinical predictors were entered into a Cox proportional hazard model with backward stepwise regression was performed. Researchers also evaluated the adequacy of treatment by assessing the risk factor control for atherosclerosis. The target of the risk factor control for atherosclerosis has been using the criteria of American Heart Association (AHA) and the Royal College of Physicians of Thailand. Result: During a mean follow-up of 30 months period, 81 MACE events occurred, corresponding to incidence rate 16.20, (95%CI 13.10-19.70). The number of death was 59 patients. The predictive factors, that were significantly associated with MACE, were history of chronic kidney disease (Hazard ratio (HR) 2.09, 95% confidence interval (95% CI) 1.24-3.52), myocardial infarction (HR 1.98, 95% CI 1.06-3.71), the history of gangrene or chronic ulcer or obtaining of revascularization in the legs (CLI) (HR 2.50, 95%CI 1.53-4.08), history of aortic surgery (HR 20.31, 95%CI 4.49-91.82), history of carotid stenting (HR 9.20, 95%CI 1.13-74.71), patients with history of taking warfarin (HR 2.83, 95%CI 1.19-6.72). In terms of risk factor control for atherosclerosis management, patients had reach the target in majority (>50%) only in the control of diastolic blood pressure (71.93%) and stop smoking (92.26%). Conclusion: The incidence of MACE was 16.2%. The predictive factors for high MACE in the 30 months follow up in diabetic patients with PAD was chronic kidney disease, myocardial infarction, history of CLI or history of obtaining revascularisation, history of aortic surgery, history of carotid stenting, patients with history of taking warfarin. This may be used to identify high-risk patients for MACE to assist optimize medical treatment to increase life expectancy and to decrease vascular event. There were still a large gap of improvement for risk factor control in atherosclerosis management.
location: nan, 'Thailand 
year: 2018 source: HSRI 
title: Evaluation and lesson distilled on implementation of Chronic Kidney Disease clinic, under policy of Ministry of Public Health 
abstract:The policy of Ministry of Public Health states that all hospitals under MOPH should establish Chronic Kidney Disease Clinics (CKD clinics). This study aims to evaluate the implementation of CKD clinics using mixed method research and the CIPP model. Results from 140 hospitals in 12 regional service providers showed that 70.71% of established CKD clinics in line with MOPH policy, while 22.14% already had CKD clinics prior to the MOPH policy statement, and the remaining 7.14% hospitals had not developed CKD clinic citing limitations due to area, personnel or budget. In total, 82.31% established sole purpose CKD clinics providing at least one day per week, but occupied the space used by other clinics. Whereas 17.69% did not separate CKD clinic from other health clinic and ran CKD services in parallel to other clinics. For example, some centers had a ‘CKD corner’ as part of their regular DM/HT clinic. In terms of the hospitals that had implemented CKD clinics, 44.62% of centers used both consultative meetings and two ways communication about policy, goals, future plans of CKD clinics to all health personnel and other stakeholders. Whereas, 27.69% used only two ways communication to realize policy, goals and planning of CKD clinic to among interested parties. The remaining 3.08% hospital used no clear consultative process in developing their clinics. Almost all hospitals reported that the supporting budget for CKD clinic was insufficient. Most hospitals (63.21%) funded the establishment of their CKD clinics from their own operating budgets and some fund support from National Health Security Office (NHSO). In terms of human resource, 58.46% have professional team (full) including physician, nurse, pharmacist physical therapist, and nutritionist or Dietitians. However, we found that 20.77% of hospital did not have funded position for nutritionists and in this cases, the advice about nutrition was provided by nurses. All hospitals with professional nutritionists funded this position of their own accord with temporary employee’s position. In addition, 95.38% of all hospital had implemented and maintained CKD patient databases, but only 42.31% of these contained all recommended clinical measures such as Serum Cr and eGFR, blood pressure, blood sugar, take ACE-I or ARB drug, and urine protein. For the most part, patient data were not utilized to track patient disease progression. Most personnel reported the reason for not using routine CKD patient data to gauge patient disease progression and outcomes was excessive workload. In general, CKD patient data was mainly used to report CKD’s KPI to the Ministry of Public Health.
location: nan, 'Thailand 
year: 2018 source: HSRI 
title: Effectiveness Evaluation of CARE-call System on Medication Adherence and Reduction of Default Rate in Tuberculosis 
abstract:Thailand is one of the 14 listed countries encountering TB, TB/HIV and MDR-TB burden. Poor adherence could cause longer treatment, drug resistance, relapse and death in TB patients. With limited-resources, the coverage of Directly Observed Treatment, Short Course (DOTS) is low. Most of TB patients are under self-medication or family-member DOT, which a forgetfulness to take medicine or an improperly early medicine discontinuation caused by side effects or etiological misunderstanding may exist. Most of adherence measurements performed at a next follow-up, not at real-time, is considered as an end point.  Hence, TB/HIV Research Foundation has developed a CARE-call system, an ICT-based medication adherence monitoring system having an electronic pill box (CARE-box) to further function by alarming patients to take medicine, notifying a health care worker (HCW) to follow up a non-adherence patients and providing two-way communication for the patients seeking for advice from the HCW. In order to evaluate the system’s effectiveness, 300 TB patients were randomly recruited into intervention or control group. Preliminary result obtained from treatment-outcome available participants showed that statistically higher adherence rate was observed in the intervention group while treatment success rate is at 88.2%, higher than the 85% NTP target and lost to follow-up cases were found only in the control group. The CARE-call system was proved to achieve its two-way communication function under around four-time lower per capita cost compared to that of the DOT supported by the global fund. Qualitative study remarked the benefits of CARE-call system through the CARE-box including alarming system, daily pack, two-way communication by meeting the satisfactions of the all the participants invited to attend focus group discussion. From the result, it is believed that the CARE-call system could improve the TB patient’s medication adherence and provide two-way communication at low cost, which is more suitable for a high TB burden country like Thailand to achieve the NTP targets for treatment success and loss to follow-up rates. However, the stability of CARE-call should be improved and provide more useful functions to facilitate the TB treatment and care.
location: nan, 'Thailand 
year: 2017 source: HSRI 
title: Developing Appropriate Tools for Hearing Screening in Preschoolers 
abstract:The main objective of this project was to develop a cost effective, tablet-based hearing screening system that can perform a rapid minimal speech recognition level test. An android-based screening application was developed. The screening protocol involved asking the child to pick pictures corresponding to the set of predefined words heard at different sound levels offered in a specifically designed sequence. For screening purposes, the developed screening system was 100% sensitive (95% CI = 83.18% to 100%) for children with speech reception threshold (SRT) or pure tone average threshold > 25 dBHL, with a specificity 0f 79.44% (95% CI = 70.83% to 86.01%). The time taken for screening of each child was less than 2 minutes on average, compared to 12 minutes required in normal procedure.  Also, to explore other options that could suit a variety of resource settings, the secondary objective was to implement and evaluate standard pure tone audiometric measurement and tele-audiometry functions on the tablet-based system.  It was found that, with additional hardware to increase the dynamic range, function-wise both could successfully be realized. However, due to calibration difficulties especially for the bone-conduction audiometry, accuracies were found to be less than those measured with standard audiometric equipment. Still, the results were encouraging enough to warrant further research and development on this.
location: nan, 'Thailand 
year: 2018 source: HSRI 
title: Borderless Health: Crossing the Borders for Health Care in Thailand among Burmese, Laotian, and Cambodian 
abstract:Border health care is a complex situation, and is becoming even more so due to the differences of socio-cultural, political-economy, and geographical context. Notably, Thailand is the heart of Southeast Asia and bordered by Myanmar, Cambodia, Laos, and Malaysia. The movement of people has been thus far featured across the border seeking the health care in Thailand which is referred to as, ‘border health’. Each year, the number of people from neighboring countries across border to receive health care in Thailand has been increasing. This study aims to explore border health care situation in 3 provinces – Ubon Ratchatani
(Thai-Lao border); Sakew (Thai-Cambodia border); Tak (Thai-Myanmar border) using qualitative research methods – in-depth interview, participant observation, and focus group discussion. The participants are divided into three groups: policy makers, health professions and NGOs, and patients who crossing borders seeking health care in Thailand. This study shows that social determinants – geography, politics, health service, belief, culture, networking and social supports. Moreover, due to the politics of neighboring countries, the Thai health services in border areas must adopt different approaches of health surveillance system. The public-private partnership between the government and NGOs enhances the effectiveness of border heath care system.
location: nan, 'Thailand 
year: 2018 source: HSRI 
title: A Model of Participation Health Public Policy Development of Long Term Care Fund for the Elders In E-SAN Communities by Community Participation 
abstract:This Research and Development research focused on developing the model of Participation Health Public Policy for the Elderly Care Fund in the community at Northeastern of Thailand (E – San) by community participation process. Data were collected by using both qualitative and quantitative methods including survey, observation, in-depth interview, focus group discussion, and documentation reviews. The participants consisted of 11,109 elders, 660 elderly caregivers, 15 elderly care managers, 264 involved people, and 28 observation participants. Data were collected from October 2016 to November 2017 and were analyzed by using content analysis, percentage distribution, 95%CI, and McNemar Test. The study found that: 1) the situation of long-term dependency care needs of in the elders had a prevalence of dependence in the elders 14.14% (95% CI 13.5 - 14.8), with dementia 15.20%. (95% CI 14.6 - 15.9). Only 43% of dependent elders had accessed to long-term care benefits which was followed the long-term care fund policy in the pilot area. The major obstacles were the problem of inadequate provision of personnel to local government organizations and the burden of care manager. 2) The process of driving long-term care policy into public policy to create public participation in elderly care consisted of 3 components: community involvement, creating knowledge for public policy of long term care, and integrating with the policy-making agency in the area that could lead to the public policy to practice in the area. 3) The community participation increased in every componence. This enabled the long-term care fund to be implemented and encouraged the elders with dependency be accessed to long-term care services increased significantly (p-value <.001). The quality of life of caregivers was also improved significantly (p-value <.001). However, it was found the level of disability was no statistically significant difference in the elderly who received care services under long-term care fund before and after the study. Long-term dependence is a problem and long-term care needs in the elders. Health Public Policy of the long-term care for the elderly is a social movement for the cooperation of network partners, especially local governments and primary health care, to drive important government policies, that can lead to practice in the area. This will lead to the development of long-term care for the elders in the community to support the elderly society in the future.
location: nan, 'Thailand 
year: 2017 source: HSRI 
title: The development of tool for diagnostic and monitoring patients with Parkinson's disease 
abstract:Purpose: To study pattern of tremor symptoms in Parkinson’s disease patient for differential diagnosis from other symptoms, including related movement disorder and study measure parameters of tremor and create the system to collect the data with wireless internet. Method: This study particularize 2 periods 1) To develop assisted device for detect tremor symptoms, including tremor assessment device with tremor analysis software and spiral drawing 2) To enroll population who have tremor symptom 100 sample and manufacture 40 device give to 20 hospital for test this device. Results: This study during in period 1, to design and develop tremor device for diagnostic and monitoring patients with Parkinson's disease. This device include hardware that can detect accelerometer 3 axial and gyroscope 3 axial and tremor analysis software that show angular rate, angular rms, peak rate, peak frequency and other parameters and can save the data by notebook or android technology. Tremor device was designed modern form, small sensor board as a wristwatch and can take pulse rate. This device can set time to test. In part of the signal made stably and reduce to send error signal. Conclusion: In the part of develop tremor device in episode1 and 2 focus on practical use of medical device, that save the data from user and have to design with regard to available use in daily, safety , smart and technology is more modern.
location: nan, 'Thailand 
year: 2017 source: HSRI 
title: Chondrocyte Cell Sheets for the Treatment of Articular Cartilage Defects 
abstract:Cell sheet technology is applied to human articular chondrocytes to construct a tissue-like structure as an alternative treatment for cartilage defect. The effect of a gelatin manipulator, as a cell sheet transfer system, on the quality of the chondrocyte sheets was investigated. The changes of important chondrogenic markers and stress fibers, resulting from the cell sheet manipulation, were also studied. The chondrocyte cell sheets were constructed with patient-derived chondrocytes using a temperature-responsive polymer, and a gelatin manipulator as a transfer carrier. The properties of the cell sheets including sizes, expression levels of collagen type II and I, and the localization of the stress fibers were assessed and compared with those of the cell sheets harvested without the gelatin manipulator. Using the gelatin manipulator, the original size of the chondrocyte cell sheets was retained with abundant stress fibers and a decrease in the expression of collagen type II. Without the gelatin manipulator, although the cell shrinkage occurred, the cell sheet with suppressed stress fiber formation showed significantly high levels of collagen type II. These results supported that the changes of the stress fiber formation in the chondrocyte cell sheets affected the production of the chondrogenic markers. The densely packed tissue-like structure possessed a good chondrogenic activity, indicating its potential use in autologous chondrocyte implantation to treat cartilage defects. One of the challenges in cartilage tissue engineering is the maintenance of the chondrogenic activities during long-term culture. To overcome this problem, we proposed a new culture surface using the fifth generation dendrimer-immobilized surface (G5). Chondrocytes cultured on this surface formed various aggregates, providing desirable three-dimensional structure that closely mimicked the native environment of chondrocytes. As a result, higher chondrogenic markers (collagen type II and aggrecan) with lower de-differentiation marker (collagen type I) were observed in the cells on G5 surfaces as compared to those cultured on traditional polystyrene surfaces. This new surface would be beneficial for chondrocyte cell sheet engineering in our future study.
location: nan, 'Thailand 
year: 2017 source: HSRI 
title: Development of rapid screening tests for neurodegenerative diseases for self-reliance and sustainable development 
abstract:Alzheimer’s disease (AD) is a primary common neurodegenerative disorder worldwide and increases prevalence in elder ages of life span. The critical detection of early diagnosis is the mostly important to support treatments to defense this incapacitating disease. Amyloidbeta proteins have various significant physiological or pathophysiological effects on AD progression. It was affirmed that amyloid-beta protein levels are detected for preclinical diagnosis and prognosis as a reliable biomarker for neurodegeneration. The available methods for detection of amyloid-beta proteins are time consuming and complicated operations. Herein, a gold nanoparticle-labelled dot blot immunoassays was had been developed for detection of beta amyloid 1-42 oligomers providing high potential early diagnosis for AD. The optimization of direct dot blot immunoassay assay was investigated and the interpretation of the colorimetric results can be visualized by naked eyes.
location: nan, 'Thailand 
year: 2017 source: HSRI 
title: A Study of Work load and productivity among health personnel in District Health Promotion Hospitals 
abstract:This descriptive mixed method study aimed to 1) investigate workload and factors associated with productivity of health personnel in District Health promotion Hospitals 2) describe relationship between workload and existing staffs and 3) formulate policy recommendations for health workforce planning and development. Stratified random sampling was applied to select samples for quantitative data collection. 48 District Health promotion Hospitals (DHPH) of 5 sizes (S,M,L,Extra and special size) were selected from 12 provinces in 12 health regions of Ministry of Public Health. All 336 health personnel in 48 selected DHPH were requested to record their daily time spent and productivity in electronic forms for 3 months. Purposive sampling was applied to select 8 outstanding DHPHs from 4 geographic regions across country. Focus Group Discussions were conducted, all health personnel who working in selected settings were participated. Descriptive statistic and content analysis were applied for data analysis. The main findings from this study indicated that 1) Health personnel in DHPH spent their working hours for curative activity 60%-70% more than health promotion and prevention activities which were their major responsibility 2) Comparing with staffing standard and current workload, there was shortage of health personnel in DHPH. In average each staff provided 1.2 FTE to complete their jobs. They also complaint about not balancing between their effort and reward, they did not get overtime payment and career advancement. 3) Health personnel had to share 30% of their working hours for administrative and clerical jobs which led to decrease time to provide health services. These jobs consisted of performance reporting associated with MOPH mandatory indicators, financial and accounting report, supply and inventory document and input data into management information system for various public agencies etc. These finding suggested that, MOPH should improve staffing standard and allocation, improve morale and optimize resources utilization. Moreover, development of administrative competency for directors of DHPH and re-orientation of mandatory reporting system need to be concerned as well.