plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Willingness to Accept and Willingness to Pay on a COVID-19 Vaccine Booster Shot in Thailand 
abstract:The study of willingness to accept and pay for a COVID-19 vaccine in Thailand aims to 1) explore the prevalence of accepting the COVID-19 vaccine and vaccine booster shots 2) factors associated with accepting the COVID-19 vaccine and vaccine booster shots 3) reasons and willingness to pay for the COVID-19 vaccine and vaccine booster shots and 4) the policy recommendation for the COVID-19 vaccine and vaccine booster shots. This study conducts 3 phases. Phase 1 is to study the prevalence and factors of accepting the COVID-19 vaccine and vaccine booster shots by cross-sectional research of having vaccinated COVID-19 group and having not been vaccinated COVID-19 group, covered four regions in Thailand, by an online survey questionnaire. The total sample is 1,740 used multiple stratified sampling techniques. Data analysis were by a descriptive statistic and multiple logistic regression. Phase 2 is associated with exploring the reasons and willingness to pay for the COVID-19 vaccine and vaccine booster shots. The developed questionnaire is from an online survey. Data analysis is a descriptive statistic. The results from phase 2 are defined policy recommendations. Phase 3 is an expert and stakeholder meeting to propose and discuss policy recommendations. The result showed 86.38% of respondents reported the COVID-19 vaccine acceptance. Respondents had no vaccination accounting for 9.16%, 10.76%, and 53.19% for the first, second, and third doses, respectively. 66.72% of the respondents accepted to have the next dose of the COVID-19 vaccine. Only 8.22% of the respondents refused the COVID-19 vaccine. One-third of the respondents received their desired COVID-19 vaccine. Factors related to the willingness to accept the COVID-19 vaccine and vaccine booster shots were an intention to take the vaccine, vaccine efficacy, attitude towards the COVID-19 vaccine, some doses of the COVID-19 vaccine, age, living area, having Influenza vaccination history, medical personnel, and income. Reasons and willingness to pay for the COVID-19 vaccine and vaccine booster shots were self-efficacy, safety, and proof by WHO. The main reason for refusing the COVID-19 vaccine was negative news on vaccines. Whereas the main reasons for the COVID-19 vaccine acceptance were protecting themselves, the safety of their families, social responsibility, herd immunity, and safety of their co-workers. One-fifth of respondents reported the willingness to pay for a booster shots vaccine between 1-5,000 Thai baht. News objectivity, in a particular vaccine against the severity of illness more than prevention, increased confidence towards the vaccine to higher-educated and higher-income groups, promoted a campaign for a single status group, priority groups for vaccination, combating fake news, and developed efficacy of the COVID-19 vaccine created in Thailand were the policy recommendations for the COVID-19 vaccine and vaccine booster shots in Thailand.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Study and development of mobile isolation precaution unit 
abstract:During the COVID-19 pandemic, the patient isolation chamber is crucial as it helps reduce the infection, numbers of medical personnel while transferring patients, and time, as well as protect their safety while taking good care of the COVID-19 patients. The general negative pressure chambers are currently expensive and have various limitations. For example, unable to move intensive care patients with ventilators, inconvenient in some medical procedures e.g., radiation treatment or CT scan, inconvenient and high costs for maintenance, and lack of quality testing and certification of equipment in safety and performance. Therefore, the MTEC research team had developed the PETE (Patient Isolation and Transportation Chamber), a device for transferring patients with respiratory tract problems. The PETE consists of 2 main parts; a clear plastic patient isolator and a negative pressure unit designed to control the air circulation inside the chamber. This PETE innovation is developed in consideration of local manufacture, reduction of shortage necessary medical equipment, and future improvement on the medical devices in accordance with global safety standards. The PETE is designed efficiently and approved after being reviewed along with literature and solution ideas gathered from concerned parties. The outcomes attached with this innovation are an air circulation system, a high-efficiency particulate air filter (HEPA filter), and a UV-C light sterilization system. From a study of current problems and reviews by actual users from 10 sampling institutions, the MTEC research team had digested and concluded for specification of the equipment which its main characteristics or essential features of a product are as follows: Compatible with existing patient transport equipment such as spinal board, stretcher, or scoop, The chamber can be put into the X-ray machine and CT scan, Foldable chamber requires small space to keep and be easy to transport, Pre-inlet filter prevent redundant disease, Chamber gloves ensure safe patient manipulation and additional ports for connection external medical devices and Complies with ISO 14644 standard (Clean room and associated controlled environments), IEC 60601-1 standard (electrical safety testing standard for medical devices) and IEC 60601-1-2 (electromagnetic compatibility)
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Establishment and Development of the System for DNA Sequencing of Patients with Genetic Diseases, Rare Diseases, and Disabilities 
abstract:Rare diseases affect more than 350 million people worldwide. Of those, more than 80 percent are of genetic origins. The diseases are severe, frequently cause congenital deformities, and rapidly deteriorated. Diagnosis of rare diseases is complicated and could take up to 8 years. Long-lasting diagnostic procedures mean wasting time and opportunity of medical personals to treat other patients, several laboratory tests, repeated hospital admission, and unnecessary treatment. These deteriorate the physical, psychological, and economic conditions of the patients and their families. To date, a vast number of patients with rare diseases lack an opportunity to access precise or correct diagnosis and treatment. Previous studies have demonstrated that more than 52 million children worldwide are died before the age of 5 years due to rare diseases. These show that urgent implementation must be employed to tackle undiagnosed rare diseases. With the Next Generation Sequencing (NGS) technology including whole exome sequencing (WES) and whole genome sequencing (WGS), up to 50 percent of rare diseases have been successfully diagnosed in the last 10 years. NGS has improved disease prevention, prenatal diagnosis, prognosis, and pharmacogenomics. Although WES/ WGS which are the short-read technologies (< 150bp nucleotides) have increased diagnostic yield of rare diseases, the yield is limited at 50 percent of cases. One founding reason is that short-read WGS is unable to diagnose certain molecular pathologies including structural mutation, inversion, and repeats. Our research team therefore has utilized a recent sequencing technology “long-read sequencing”, which can sequence more than 20,000 nucleotides in length, to do whole genome sequencing for 60 individuals comprising patients and their parents. We successfully performed the high-molecular weight DNA extraction, checked the DNA quality, optimized sequencing condition, analysed the genome information and sent the genome data to NSTDA for the establishment of long-read genome database. We have found that long-read sequencing could identify the diversity of genomics including single nucleotide variation (SNV), in/del (insertion/deletion), structural variation (SV), and copy number variation (CNV) which were unable to be identified by short-read sequencing. During the process which required short-read exome/genome sequencing and subsequently long-read sequencing, we could published 22 articles in international academic peer-review journals. The database will be beneficial to genomic research and medical service in the era of genomics medicine. The long-read WGS has a great potential to be the new standard in the era of precision medicine when personalized therapy can benefit the patient, family, society, and economy.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: The Development of the Essential Competencies of Registered Nurses during and after the COVID-19 Pandemic: A Case Study of SongKhla Province in Thailand 
abstract:This research aimed to develop essential competencies of registered nurses in terms of nursing for emerging infectious disease COVID-19 and develop a competency development model of emerging infectious disease COVID-19 nursing of primary, secondary, and tertiary health service units in collaboration with stakeholders. Research implementation was conducted using Emancipatory Action Research. Research participants were 6 physicians and 53 registered nurses, of which 10 were from primary, 31 from secondary, and 12 from a tertiary health service unit. Research instruments consisted of 1) instruments for quantitative data collection including the questionnaire of essential competencies of registered nurses in terms of nursing for emerging infectious disease COVID-19, the questionnaire of the competency development model of registered nurses in terms of nursing for emerging infectious disease COVID-19, and questionnaire of satisfaction of competency development model of emerging infectious disease COVID-19 nursing, 2) instruments for qualitative data collection including 1) behavioral-based interview form, 2) in-depth interview form, and 3 focus group discussion form. Quantitative data were analyzed using descriptive statistics and content analysis was used for qualitative data. Research results revealed that 1) registered nurses of primary, secondary, and tertiary health service units had an overall higher mean score of essential competencies of registered nurses in terms of nursing for emerging infectious disease COVID-19 in each loop of research. A higher mean score was found on both professional and technical competencies. 2. Competency development model of registered nurses in terms of nursing for emerging infectious disease COVID-19 consisted of 3 components including practice guidelines, competency development method, and factors promoting competency development. Practice guidelines consisted of 5 main steps including 1) specification of essential performance competencies, 2) development of monitoring system, support, and empowerment, 3) specification of self-competence development guideline, 4) implementation of the competency development plan and, 5) summarization and report of development result. The Competency development method consisted of 6 activities including 1) workshop, 2) on-the-job training, 3) learning from experts, 4) coaching, 5) self-study, and 6 knowledge sharing. Factors promoting competency development included the role of nursing leaders, policy and explicit practice guidelines, and a good attitude towards the profession
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Prediction of chemotherapeutic response using transcriptomic and proteomic analysis in patients with lung cancer 
abstract:Lung adenocarcinoma is the most often diagnosed cancer and the primary cause of cancer death worldwide. Chemotherapy for lung cancer is still main treatment. However, a response rate is very low. In this study, we aim to identify serum protein indicator for predicting response to a platinum plus anti-metabolite regimen through integrative analysis of transcriptomics and proteomics. Methods: A total of 27 patients with lung ADC (17 non-responders, NR and 10 responders, R) receiving a combination of carboplatin and gemcitabine treatment was included. For transcriptomic study, RNA was extracted from the frozen biopsy tissue of patients. Sequencing was performed on the Illumina/HiSeq2000 platform and differentially expressed genes were converted to proteins using UniProt database. For proteomic study, serum from 6 responders and 6 non-responders was subjected to the label-free liquid chromatography tandem mass spectrometry. Blood-based proteins reflecting the tissue-specific biomarker were obtained using Venn diagrams. Candidate proteins were validated by western blotting. Results: We found that 417 genes, including 52 up-regulated genes and 365 down-regulated genes were differentially expressed. In addition, we also showed that there were 26 up-regulated proteins and 5 down-regulated proteins. Based on integrative analysis, alpha-1-acid glycoprotein (A1AG1) and fibrinogen alpha chain (FIBA) were detected in both tissue and serum of patients, with a higher level in responders than non-responders. Additionally, serum expression level of A1AG1 and FIBA was shown to be link chemotherapeutic response. Conclusion: A1AG1 and FIBA indicating as tissue-specific biomarkers may be used for identifying ADC patients who would benefit from the platinum plus antimetabolite treatment.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Study of Germline Genome Data in Thai Cancer Patients: A Pilot Study for Genomics Thailand 
abstract:Cancer is the first-leading cause of death in Thailand. Cancer is caused by gene mutations that control the cell functions in cell growth and division. The genetic mutation causing cancer can be divided into two broad categories based on the tissues of origins: somatic mutation and germline mutation. The germline mutation passes directly from parent to offspring which can be detected in every cell within the body. Cancers associated with germline mutations are called hereditary cancers. Most hereditary cancer patients have similar clinical symptoms and signs to sporadic cancer, it is difficult to distinguish the hereditary cancers for the benefit of preventing, treating and screening cancer in at-risk family members. In addition, hereditary cancers account for up to 12 percent of all cancer diagnoses. Thus, genomic medicine has the potential to make the diagnosis more accurate. This project aims to utilize genome sequencing technology to identify germline mutations and diagnose hereditary cancer syndromes among Thai cancer patients, this would also create an opportunity to build large genome database for future study of the cancer susceptibility genes and polygenic risk of cancer for Thai population. Moreover, this project has created collaborative network among medical schools, large university-affiliated hospitals and cancer centers to support and share experience, exchange knowledge, and facilitate the integration of genomic medicine in cancer care. Study by next-generation sequencing (NGS) found that approximately 16% of cancer patients participated in this study harbored germline pathogenic or likely pathogenic variants in various cancer susceptibility genes. This information was useful for further expanding to identify at-risk family members with appropriate cancer screening, early detection and prevention in the future. Genetic diagnosis, genome-guided screening and prevention of cancer were also cost-effective and would be a model of the implementation of genomic medicine in national healthcare system.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: The association between the risk factors during pregnancy and first year of life and the occurrence of metabolic syndrome and vascular disease at the age of 30 years 
abstract:The objective of this study was to determine the risk factors during the perinatal and the first year postnatal period that were associated with metabolic syndrome at the age of 30 of offspring. Methods: We invited offspring whose mother had participated in a study of Chiang Mai Low Birth Weight Study (CMLBWS) in 30 years follow-up. History, physical exam, and blood sampling were collected to determine whether participants have metabolic syndrome. We analyzed the association between the perinatal-postnatal risk factors and metabolic syndrome (MS). The risk factors included the history of the small for gestational age (SGA), history of rapid growth in weight during the first year of life (catch-up growth), maternal body mass index, weight gain during pregnancy, gestational age, and maternal age. The Local Research Ethics Committee approved the study and participants gave written consent. Results: Three hundred and seventy mother and 418 offspring agreed to participate in the present study. Two hundred offspring were males and 218 were females. The mean age was 30.75 years old. There were 72 offspring (17.22%) with MS and 5 offspring were SGA (6.94%). There was no statistically significant difference in the incidence of MS between offspring with SGA (19.23%) and normal birth weight (17.09%) (p = 0.780). The percentage of MS in offspring with a history of catch-up growth and without catch-up growth was 22.22% and 15.83%, respectively. However, this trend was not statistically significant difference (p = 0.503). In addition, it was also found that other factors in mothers during the pregnancy had association with occurrence of MS in offsprings. Offsprings, who their mothers had a history of high body mass index, had an association with the occurrence of MS in offsprings than those without such history. Conclusion: Maternal body mass index of mothers during pregnancy were associated with MS. There was a none statistically significant trend between catch-up growth and MS. However, no association was found between birth weight and MS.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Roles of Networking in Primary Care System, for Screening and Monitoring of COVID-19 among at-Risk Groups in Southern Border Provinces, Thailand 
abstract:This study is a mixed method research, collecting quantitative and qualitative data in 2 districts of Yala, Pattani and Narathiwat province, in totally 6 districts. The study aimed to determine the roles of networking in primary care systems for screening and monitoring for covid-19 risk groups. Four hundred eighty-one people were collected the quantitative data using questionnaire about knowledge of practices guideline, roles of practice and the stratification of networks on screening and preventing the risk groups of covid-19. The data collection was arranged on January – March 2021. The qualitative data were collected in 270 people, using focus group and indebted interviews, running on April – December 2021. Quantitative data were analyzed using frequency and percentage, while qualitative data were used thematic analysis by Miles & Huberman (1994) conceptual framework. The quantitative results showed that most participants were middle aged with age between 36 and 45 years old, 31.2 percent. Following by, old aged was 28.3 percent. More than a half were female, 56.3 percent. The overall knowledge on screening and monitoring on covid-19 pandemic in risk group was in the high level (M=3.01, SD=.53). However each aspect of knowledge such as patient care and infection control, Monitoring of people exposed to COVID-19 and community control of COVID- 19 pandemic, and coordination and data management were rated as moderate (M=2.99, SD=.57, M=2.98, SD=.57, M=2.91, SD=.59). The scarification of roles and work on screening and monitoring on covid-19 in risk group was found a high level (M=3.29, SD=.50). The overall in roles performance for screening and monitoring of COVID-19 at risk groups was rated the high (M=3.19, SD=.51). Qualitative findings were presented in six themes: 1) role of networks in COVID-19 screening and monitoring, 2) facilitators of role performance, 3) factors influencing the spreading of COVID-19, 4) barriers for networking, 5) needs for better performance, and 6) outcomes of networking. The networks consisted of five principal organizations: health professionals, volunteers including village health volunteers, community leaders, religion leaders, and local governments. These groups of people unified their efforts in responding to the government policies and proactively implementing COVID-19 screening and control measures in these three southern provinces. These organizations created their new and voluntary role and combined these roles into their principal functions to respond to health needs of families and communities taking into account the unique cultural and religious contexts as well as ways of life. Dedicated religion leaders provided guidance on how health measures could be observed in accordance with Islamic principles.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Effectiveness of convalescent plasma therapy in Covid-19 patients with moderate to severe pneumonia 
abstract:Coronavirus disease 2019 (COVID-19) is a contagious disease which cause by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. COVID-19 epidemic first appeared in Wuhan, China in December 2019. The World Health Organization (WHO) declared a Public Health Emergency of International Concern and then on 11 March 2020 announced as a pandemic. Since there is no specific drug and treatment, the use of convalescent plasma (CP) may serve as an alternative treatment for patients with COVID-19. This study aims to determine the effectiveness of CP therapy in COVID-19 patients with moderate to severe pneumonia. In our trial, 186 patients were enrolled including 111: male and 75: female, age of 21-91 years, and 49 patients completed the trial. The primary outcome showed 95% (177 of 186 patients) of patients were discharged, whereas 5% died. Among the 49 patients, clinical assessment was evaluated using by Chest-X-Ray, COVID-19 antibody levels and laboratory parameters. the kinetics of anti-nucleocapsid, anti-spike and neutralizing antibody level of 49 patients were significantly increased in 3-, 7- and 14-days post-transfusions respectively. Moreover, IFN-β, IL-6, IL-10 and IFN-α have significant difference among the groups. These findings indicated that most patients with low SARS-CoV-2 antibody titers tended to higher recovery rate after receiving high antibody-titre convalescent plasma. Nevertheless, we could not conclude that outcomes were entirely due to only CP treatment.