plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Long Term of Antibody Response to Hepatitis B after Immunization with Hepatitis B Vaccine at Birth, Combine DTPa-HiB-HB-IPV or DTPw-HiB-HB+OPV at 2, 4, 6 and 18 Months in Aged 4 and 5 Year Old. Antibody Response to Hepatitis B after Immunization with Monovalent Hepatitis B Vaccine at Birth, and DTPw-HiB-HB+OPV at 2, 4, 6 Months as Part of National Program Immunization 
abstract:The universal hepatitis B vaccination for Thai newborns was integrated into the EPI in 1992. After that HB vaccine schedule had to be changed for facility to provide the vaccination. In the future, WHO will be not provide a weakened poliovirus given by mouth to infants and changed to be an inactivated poliovirus given by injection as combine vaccine likes pentavalent (wP) or hexavalent (aP) vaccine which result in the infant will be received five doses of HB vaccination in age at birth, 2, 4, 6 and 18 months. Therefore, this study is the long term to determine anti-HBs titers in the new born whom were received combine wP or aP vaccine.This study is determine anti-HBs titer in the new borns in age at birth, 7, 18, 19, 24, 36, 48, 60 and 72 months. And the results show that aP vaccine group had the anti-HBs titer and GMT level higher than wP vaccine group. However, the vaccination in age 18 months (5th dose) was influent to stimulate anti-HBs titers more than 4th dose for the both of combine vaccine. Then the long-term study show that the ant-HBs titer was initiate decreasing at age 2 year old and rapidly dropping at age 3 year old but the GMT level was remain in the same log scale in age between 3 - 6 year old. Children aged 6 year old had the level of anti-HBs (anti-HBs ≥ 10 mIU/ml) 94.2 and 62 of aP and wP vaccine group, respectively. Thus, the 5th dose for the both of combine vaccine was influent to stimulate the long term protective HB infection likes the long term study of the antibodies persistence more than 20 years after infant received monovalenct hepatitis B vaccination. Moreover, the study of antibody response to hepatitis B after immunization with monovalent hepatitis B vaccine at birth, and DTPw-HiB-HB+OPV at 2, 4, 6 months as part of national program immunization was imitating in June, 2019. After 1 and 6 moth of the 4th dose stimulation found that anti-HBs and GMT level was highly increasing levels and similar with the results of aP vaccine group at age 7 and 18 month. Therefore, the combine vaccine in EPI program might be highly effective long term against HBV infection.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Economic Evaluation of Prenatal Screening Fetal Aneuploidies in Thailand 
abstract:In Thailand, incidence of chromosomal abnormalities such as Down syndrome is 1:800 - 1:1,000, with the risk increasing with maternal age. However, 75-80 percent of newborns with Down syndrome are found in pregnant women who less than 35 years old. In 2016, the subcommittee on health promotion and disease prevention Under the National Health Security Board (NHSO) approved the screening of Down syndrome in pregnant women as a new benefit for pregnant women aged 35 and over, and the NHSO has had agreed to expand the quadruple test in pregnant women of all age groups (quadruple for all). In 2019, there was A report evaluating the Down Syndrome Prevention and Control Pilot Program in five provinces which found that the acceptance rate for quadruple screening was relatively high, but the results of quadruple screening were false positive around 95 percent. This situation resulted in a larger number of unnecessary amniocentesis which lead to the service system cannot support. Currently, there is a non-invasive prenatal screening test (NIPT), which is a screening test for chromosomal abnormalities of the fetus by examining the genetic material of the fetus in the mother's blood, such as Trisomy 13, Trisomy 18, Trisomy 21. This test is very high sensitivity and specificity. This study used a model decision-tree to analyze the cost and benefit of various prenatal chromosomal abnormalities screenings compared to no screening, and budget impact analysis From the cost-benefit analysis, it was found that, from a government perspective, NIPT was the most cost-effective among the three groups. It was found that pregnant women younger than 35 years had a 2.37:1 cost-benefit ratio. Pregnancy over 35 years, the proportion is 12.41 : 1 and all pregnant women the proportion is 5.44 : 1. Since the cost of NIPT testing is a factor that increases the cost-effectiveness of universal NIPT testing, at the NIPT test price of 1,805 baht (80 percent reduction) found that the increased budget from serum screening at the acceptance rate that varies from 50 to 100 percent is 19-39 million baht. In summary, there are policy recommendations as follows: Governments should introduce NIPT screening policy to screen all pregnant women nationally which may be required to limit the price of NIPT examination by various agencies to be in the range of approximately 1,800 – 2,000 baht.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: To Investigate the Genetic Variants Responsible for Cannabis Dependence in Thai Population 
abstract:Objective: The objective of this study was to identify gene or genetic variants that would be responsible cannabis dependence in Thai people. Methods: We studied 144 cannabis dependent Thai people and 20 cannabis non-dependent people using whole exome sequencing and bioinformatic analysis. We used an integrated bioinformatic pipeline that combines two techniques: gene collapsing and disease module detection to identify potential genes involved in cannabis dependence. Results: Disease module detection analysis identified a single module of 53 genes with significantly higher rate of potentially damaging variant careers in cannabis dependent group compared to non-dependent group (Percentile Bootstrap’s p-value = 0.0000337, FDR=0.024). Of this module, we found that MYEF2 (Myelin Expression Factor 2; MIM 619395) was associated with cannabis dependence in our Thai cohort (Fisher’s Exact p-value = 0.0013, Odds ratio = 2.43(1.38-4.23), FDR = 0.04). MYEF2 is a single-stranded DNA-binding protein. Its role is to inhibit transcription of MBP (Myelin Basic Protein; MIM 15940) gene. MBP regulates maintenance of myeline structure. Conclusion: We propose for the first time based on our bioinformatic analyses that MYEF2 was associated with cannabis dependence.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Distribution of Physician to Health Care Setting in Hardship or Remote Areas: A Study of Policy Option 
abstract:Over the past 5 decades the government initiated compulsory three years rural service and scaled up the production. Although the number of physicians is constantly increasing, there is a lack of policy to control their mobility. The distribution of physicians varies over area and time, increases, or decreases in their number are important issues for the healthcare system. This study aimed to examine associated factors and synthesized policy options to increase the supply of rural physicians. Mixed method descriptive research design was conducted. Data collection process comprised of STEEPV analysis from document review, expertises indepth interview, rural physician stock and flow analysis, survey of factors associated with rural retention among 121 last 5 years graduated physicians, applied DCE method to determine job preference among 400 last year medical students and introduced Modified Delphi method comprising panelist with 32 expertises to develop policy options. Findings showed that 1. ageing society, chronic diseases, urbanization, technology disruption are major driving forces to transform health care system in Thailand. 2. COVID-19 impacts are still to be determined. 3. primary care is a foundation of population health improvement, any where any time service is needed. 4. Tele-health, Digital health and rapid change of advance medical & information technologies can reduce the geographical imbalance in the health workforce and increase health care accessibility. 5. urban facilities, specialist residency training and low intensity of workload are preferable job characteristics among young generation of physicians. 6. rural background physicians retain in rural areas longer than others 7. Ten policy options with high impact to retain rural physician and high possibility to implement include 1) targeted admission 2) promote task shifting & sharing among health professionals with appropriate training and regulation 3) senior/expertise supervision system 4) Telemedicine/Tele-consultation strengthening 5) prosecution support 6) fair performance based payment 7) career advancement 8) good work-life balance and manageable workloads 9) cooperation among all sectors to share resource in local area 10) Decentralized HR management in the regional level to improve performance. This study suggested to improve important interventions of compulsory service, taking multiple factors of rural retention into distribution strategy. Increasing reasonably penalty rate, non-civil servant employment and demand side financing for medical students are policy measures that should be improved based on the evidence from further studies.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: A Literature Review on Utilization of Managed Entry Agreement 
abstract:When high–price drugs or new drugs with immature information about their efficacy come to market, will cause uncertainty in the health systems, especially for health–service buyers as the payers in the health systems. Managed Entry Agreement (MEA) is the tools for manage uncertainty that are widely used in many countries such as United Kingdom, two third of OECD member countries, European Union countries. MEA can be divided into two types: financial–based agreement and performance–based agreement. The financial–based agreement aims to limit budget impact through controlling drug costs. It is a simple method, effective in reduce drug prices and limit budget impact, but the details contained in the agreement are confidential, resulting in a lack of transparency. It may give some payers the benefit of such details. It can be implemented at 2 levels: population level and patient level. At the population level, consists of MEA in the model of discount / rebate, price–volume agreement, and expenditure cap. At the patient level, consists of MEA in the model of free initiation treatment and utilization cap that provides individual patient coverage. The performance–based agreement is an agreement based on the actual treatment efficacy. Sometimes referred to as health outcome–based agreement. This agreement is divided in two groups. The first group aims to optimize drug use, known as performance linked reimbursement, which consists of MEA in the model of conditional treatment continuation and pay by result. The second group aims to address uncertainty about drug efficacy with more research studies. This model of MEA is known as coverage with evidence development, or CED. It is a good solution to the problems, but it is complicated to operate, and affect stakeholders in the health systems widely, and high cost in operation. However, the decision–makers in the health system should carefully consider in the selection and implementation of MEA, as each model of MEA has different strengths and limitations, for efficient budgeting and equal access to medicines.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: System Development to Increase Accessibility of Assistive Devices with Telehealth (Phase 1) 
abstract:The study of a situation analysis and system development to increase the accessibility of assistive devices with telehealth, Phase 1 was survey research. by surveying the situation of access to assistive devices in the type of wheelchairs in Thailand regarding the supply of wheelchairs, service and access systems, system gaps, obstacles, and development opportunities as well as the possibility of implementing telehealth systems. Then develop a model of a system to increase the accessibility of wheelchairs with telehealth. The study found a wheelchair for Persons with a physical disabilities to be able to be independent living, it needs to be a customizable type of device with the physical condition and lifestyle of each person with disabilities. However, it was found that the wheelchairs that can be disbursed from the three health security funds are non-adjustable metal folding wheelchairs. which is not suitable for people with physical disabilities. At the same time, a customizable wheelchair for people with disabilities can be disbursed from the list of high-value assistive devices from the Sirindhorn National Institute for Medical Rehabilitation only. causing limitations because Persons with disabilities must pick up the equipment at Sirindhorn Institute. Or even there will be a development of hospital networks in 5 provinces to be able to disburse this type of equipment. It still doesn't add much to the device's accessibility. Combined with the disbursement of such wheelchairs, body measurements, angular measurements, adjustments, and trials are required to ensure that people with mobility disabilities get the right equipment for their disability. which requires experience and knowledge of service. Therefore, training courses for providers and intensive consultations between Sirindhorn Institute and the hospitals that provide services by telehealth will help people with mobility disabilities get a truly suitable wheelchair that is for each person with disabilities under the system model which must be further implemented piloted in the second phase study.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Advanced Clinical Phenotyping and Genotyping of Thai Patients with Familial Hypercholesterolemia (FH) for Clinical Application 
abstract:Background and Objectives: Familial hypercholesterolemia (FH) is the most common genetic cause of cardiovascular disease. This study was aimed to examine the Achilles tendon thickness using plain radiograph of lateral heels in FH subjects (diagnosed using the Dutch Lipid Clinic Network [DLCN] score above 3 [possible, probable or definite FH]), non-FH subjects with elevated LDL-cholesterol (LDL-C) >130 mg/dL and subjects with LDL-C below 130 mg/dL. The sensitivity, specificity, and optimal cutoff values with the highest diagnostic accuracy for diagnosis of FH were determined. In addition, the coronary calcium score (CAC) and aortic valve calcium (AoVC) score using computed tomography were also investigated in FH and non-FH subjects. Results: Analysis was performed among 113 FH subjects, 58 non-FH subjects with high LDL-C and 55 subjects with LDL-C <130 mg/dL. The Achilles tendons in FH subjects were significantly thicker than those in the other 2 groups. Men had thicker Achilles tendons than women, but not significantly different. The cutoff thickness values ≥6.875 mm gave the highest diagnostic accuracy of 74% with 70% sensitivity and 78% specificity. For CAC scores among 112 FH subjects and 58 non-FH subjects, the proportion of FH subjects who had CAC >0 AU was not significantly different than that of non-FH subjects but the proportion of FH subjects who had AoVC > 0 AU was significantly higher that that of the non-FH subjects (10.7% vs. 1.7%, P= 0.029). CAC scores were significantly associated with age, LDL-C burden and Thai CV risk score Conclusions: Measurements of Achilles tendon thickness by plain radiographs in 133 FH subjects showed that cutoff values of ≥6.875 mm gave 74% accuracy with 70% sensitivity and 78% specificity. The proportion of FH subjects with CAC >0 was not significantly different than that of non-FH subjects but the proportion of FH subjects who had AoVC > 0 AU was significantly higher that that of the non-FH subjects.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: The Lesson Learned on Telehealth Care Model of Home Isolation in Terms of Health Workforce in the Public Health Region 12 
abstract:The COVID-19 epidemic situation is affecting the health workforce in the public health is not enough to care for the infected people. This has led to home isolation and volunteer group was formed using a telehealth care model. The objectives of this study were to 1) learned lessons from the telehealth care model of home isolation in terms of health workforce in the public health region 12 2) study the role and operation process of health workforce 3) study the success factors, problems and obstacles in the implementation of the telehealth care model with the home isolation, and 4) to synthesize lessons to form a knowledge in the 12th health zone. Used qualitative research methodology. Data were collected through structured in-depth interviews. And online group discussions with 30 volunteers and 50 patients. Data were analyzed by qualitative content analysis. Data is checked at every step of the analysis. Using a triple check Content Analysis and interpretations creates conclusions. The results of the study revealed that the telehealth care operation model with the home isolation system consists of 1) Building human resources in the form of volunteering to help carry out work in caring for home isolation patients. 2) Understanding common goals by explaining the objectives and goals of work to all volunteers. 3) Organizing training sessions to provide knowledge on various issues related to the care of COVID-19 patients. and 4) Follow up on the activities of volunteers through online meetings. The role and operation process consisted of 3 teams: the central team, the patient follow-up team, the community team, and the corps volunteer team. The key success factors were attitudes, thoughts, beliefs towards volunteer work. Knowledge and process of developing knowledge and competence of the volunteer team the problems and obstacles encountered include accessing the database system. Health workers are not only health officials, but may also come from those who consciously go through the step-by-step construction and development process. Health promotion consultation during the operation of the system.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Immunologic and Molecular Genetics Studies of Diabetes Diagnosed Before Age 30 Years in Thailand 
abstract:Currently, there are no epidemiological studies in Thailand on diabetes diagnosed before the age of 30. Long-term studies in Thai children and adolescents have been published periodically less 5 years ago. Recent evidence has shown that the ratio of type 2 diabetes in Thai children has increased as well as type 1 diabetes. The etiology and clinical features of diabetes in children and adolescents have tendency to change according to environmental factors and lifestyles. The study of diabetes diagnosed under 30 years old, The project was to collect baseline patient data for registration of diabetic patients admitted to network hospitals across the country. Basic data from the patients were analyzed. Autoantibodies against three islets antigens, GAD65, IA2 and ZnT8 were measured in the laboratory to determine the incidence of type 1 diabetes. To examine the molecular genetics of diabetic patients diagnosed before the age of 30. This study was conducted in patients who were clinically compatible with NDM and MODY. The subject who had negative autoantibodies will be used to study the variation of diabetic genes by whole exome sequencing. Data on the number of people with diabetes diagnosed before the age of 30 in Thailand were collected from 31 network hospitals nationwide. Sample specimens were obtained from 750 diabetic patients diagnosed before the age of 30 years. 448 cases of type 1 diabetes (59.7%), type 2 diabetes 156 (20.8%), 43 cases of MODY diabetes (5.7%) A study of autoantibodies against three antigens islets GAD65, IA2 and ZnT8 found that patients with type 1 diabetes were positive 61.3 %. Of the 316 patients with type 1 diabetes, GAD antibody positive 52.2%, IA2 antibody positive 34.8%, and ZnT8 antibody positive 28.7%. Fourty-four patients clinically compatible with MODY subtype, in which diabetes is a dominant familial trait and no islets autoantibodies. Based on exome sequencing analysis, gene variations associated with diabetes were reported in 15 cases, while the other 29 patients with MODY had no previously reported pathogenic genes (MODY-X). This study, systematic nationwide, is a preclinical and scientific study that directly contributes to Thailand's cognition related to diagnosed diabetes under 30 years of age in Thailand. It can be used as an empirical reference and may lead to the formulation of appropriate public health policies related to diagnosis. Treatment and prevention of diabetes in young people in Thailand as well.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Benefit Package of Universal Coverage Scheme for Hereditary Angioedema (HAE) Caused by C1 Esterase Inhibitor Deficiency (C1-INH) 
abstract:Background: Hereditary angioedema (HAE) is a rare and life-threatening genetic disease. This disease can lead to recurrent attacks of severe swelling occurring in areas such as the face, gastrointestinal tract, and larynx. These attacks can result in hospitalization or death. Thus, effective medications are necessary for treating the acute attacks. However, Thailand did not specify medication for treatment and prophylaxis. Therefore, effective strategies for universal health coverage for the management of HAE patients remain a challenge in Thailand. This review aims to determine the extent of research in the published literature that examine benefit package and strategies for universal health coverage for the management of HAE patients in Thailand. Method: On 5th January 2022, Embase, Scopus, OpenGrey, PubMed, Science direct, Clinicaltrials.gov, and Cochrane were searched for literature published from inception. Studies evaluating the efficacy and safety of medication for treating acute attacks in HAE patients were included. Additionally, this study performed a survey of data from the drug company, experts in the field, and stakeholders. Our survey asked about the situation, cost, and health service systems for screening, diagnosis, treatment, and referring HAE patients in Thailand. Result: Of 4,834 articles identified, 28 studies were included. Twenty-four studies are original articles, one study was a systematic review and network meta-analysis, and three studies were cost-effectiveness analyses. From current trials, first-line therapy such as Plasma-derived C1 inhibitor, Recombinant C1 inhibitor Conestat alfa, Icatibant, and Ecallantide showed benefits over placebo.However, the study related to the full economic evaluation of first-line therapy in Thailand has not been provided. Conclusion: HAE may affect the budget of Thailand if patients do not receive appropriate treatment. Thus, screening, diagnosis, and effective medication for treating acute attacks are essential measures to decrease the overall HAE-related healthcare cost. However, full economic evaluation studies of first-line therapy in Thailand are needed.