plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Safety, Immunogenicity of the 4th Booster Dose of mRNA Vaccine After Three Doses of COVID-19 Vaccine, Clinical Trial 
abstract:Objective: To investigate the reactogenicity and immunogenicity of the fourth dose mRNA vaccines after different three-dose regimens, followed by a comparison between the 30 μg BNT162b2 and 50 μg mRNA-1273 groups. Methods: The prospective cohort study was performed between June and October 2022. The self-recorded reactogenicity after 7 subsequent days following a fourth booster dose was evaluated. The binding antibodies and neutralizing activity to the Omicron BA.4/5 variants were determined. Results: Overall, 292 healthy adults were enrolled and received either the BNT162b2 or mRNA-1273. The reactogenicity was mild to moderate and well-tolerated within a few days. Sixty-five individuals were excluded. A total of 227 eligible individuals received the fourth booster dose of BNT162b2 (n=109) and mRNA-1273 (n=118). Most participants, regardless of different previous three dose regimens, significantly elicited a high level of binding antibody and neutralizing activity against the Omicron BA.4/5 at 28 days after a fourth dose. The neutralizing activity against the Omicron BA.4/5 between the BNT162b2 (82.8%) and mRNA-1273 (84.2%) groups was comparable with a median ratio of 1.02. Conclusion: The findings indicated that the BNT162b2 and mRNA-1273 can be used as a fourth booster dose for individuals who were previously immunized with any mix-and-match three-dose COVID-19 vaccine.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Comparison of the Safety and Immunogenicity of Two-Dose mRNA COVID-19 Vaccine and Inactivated Followed by an mRNA Vaccine in Children Aged 5 - 11 Years 
abstract:Objective: To compare the reactogenicity and immunogenicity between the two-dose mRNA COVID-19 vaccine regimen and one or two doses of inactivated vaccine followed by an mRNA vaccine regimen in healthy children between 5-11 years of age. Methods: A prospective cohort study was performed at King Chulalongkorn Memorial Hospital in Thailand between March to June 2022. Healthy children between 5-11 years of age were enrolled and received the two-dose mRNA COVID-19 vaccine (BNT162b2) regimen or the inactivated (CoronaVac) vaccine followed by the BNT162b2 vaccine regimen. In addition, healthy children who received two doses of BBIBP-CorV between 1-3 months prior were enrolled to receive a heterologous BNT162b2 as a third dose (booster). Reactogenicity was assessed by a self-reported online questionnaire. Immunogenicity analysis was performed to determine binding antibodies to wild-type SARS-CoV-2. Neutralizing antibodies to Omicron variants (BA.2 and BA.5) were tested using the focus reduction neutralization test. Results: Overall, 166 eligible children were enrolled. Local and systemic adverse events which occurred within 7 days after vaccination were mild to moderate and well-tolerated. At one-month, post-two or post-three doses, children vaccinated with two-dose BNT162b2 (GMT 2872 BAU/mL), CoronaVac/BNT162b2 (GMT 3021 BAU/mL), and two-dose BBIBP-CorV followed by BNT162b2 (GMT 3269 BAU/mL) elicited similar levels of anti-receptor-binding domain (RBD) IgG (ns). However, the two-dose BNT162b2 and two-dose BBIBP-CorV followed by BNT162b2 groups elicited higher neutralizing activities against Omicron BA.2 and BA.5 variant than the CoronaVac/BNT162b2 group. Conclusion: The heterologous, CoronaVac vaccine followed by the BNT162b2 vaccine, regimen elicited lower neutralizing activities against the emerging Omicron BA.2 and BA.5 variant than the two-dose mRNA regimen. A third dose (booster) mRNA vaccine should be prioritized for this group.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: From Whole Genome Sequencing and OMICs Profile in Tissue and Liquid Biopsy to Novel Testing Panel for Screening, Diagnosis, Precision Treatment and Monitoring in Non-Targetable Gene Lung Cancer (Year 2021) 
abstract:Currently, lung cancer treatment has been developing in several approaches such as; conservative chemotherapy, immunotherapy, or novel targeted therapies which increase the overall response rate, survival rate with good quality of life for the patients. This study aims to explore the whole genome sequencing profile and omics profile in non-targetable advanced non-small cell lung cancer both in tissue and in liquid biopsy. The results of this research project will lead to developing of screening, diagnosis, personalized therapy, and monitor of treatment in this group of patients. We will explore the data according to Thai population which might be different from the other ethnicity and this will lead to developing the new drug for Thai lung cancer patients. This research project composed of 7 sub-research projects which we completed the first-year aim. The first, second, third, fifth, and seventh sub-research projects will continue the research for the consecutive years. Furthermore, the first, second, and the seventh subresearch projects are in the process of preparing for Next Generation Sequencing (NGS) for the second-year proposal aim. In the first year, we could prepare the good quality of DNA and RNA as our purpose in order to proceed in NGS. Regarding the third, fourth, and fifth subresearch projects we found the initial result in potential biomarkers for predicting of treatment response. We also explored the clinical characteristics of 17 locally advanced and advanced non-small cell lung cancer (NSCLC) patients. Majority of patient were male, former/current smokers, adenocarcinoma with the high prevalence of PD-L1 expression (TPS = 1-49%: 23.5 % and TPS ≥ 50%: 35.8 %). In conclusion, the study of molecular alterations in Thai lung cancer patients is very important for drug development in order to drive the innovative lung cancer treatment. However, the other important issue and concern is exploring the whole genome sequencing profile and omics profile in non-targetable advanced non-small cell lung cancer. Our research team hope the results of this research project will lead to developing of screening, diagnosis, personalized therapy, and monitor of treatment in this group of patients.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Proposal for a Digital Health Platform Synthesis Project in Pilot Health Regions Based on National Public Health Reform Policy: Addressing Emerging Infectious Diseases and Noncommunicable Diseases (NCDs) 
abstract:There are many health information systems in Thailand and various project indicators. Many of them are redundant and unable to integrate both the reporting system and the medical expense reimbursement. has not yet been fully utilized This study is an analytical study. To study and find a suitable management model and approach for the whole ecosystem that affects the drive of the digital health system. It was carried out in three parts: 1) digital health system review; The study found a digital health governance model requires collaborative governance. have a strong leadership, has authority and constantly in position There is a central agency that drives the development of digital health systems. and to focus on the standardization of the health data system There are good examples of Australia, England, Finland, and India. 2) Developed prototype tools of personal health information system; Personal health data from multiple database sources is integrated and automatically linked directly from the hospital to the central, can display health information through mobile applications and link between hospitals to use in medical treatment and 3) synthesize recommendations; to reform data management from Silo Base to Authority Base for sustainable. Therefore, there are proposals in 5 mission and it is necessary to have an agency directly responsible for the digital health system. There is a proposal for an action plan to establish National Digital Health Authority.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Experience, Barriers, Supports, and Outcomes of Pharmaceutical Care in Hypertensive Patients by Pharmacists in Primary Care Cluster, Health Region 6 
abstract:The sequential embedded mixed-method research consisted of two phases. In phase 1, the qualitative phase was aimed to explore the experience, barriers and supports of the pharmacists in the primary care cluster. Focus group discussion was conducted with 24 pharmacists from 6 provinces of the health region 6. Findings of content analysis comprised three main themes: barriers and supports from the policy; colleagues; and the pharmacist. The barrier was the health information access and incomplete data flows from the primary care cluster to the hospital and vice versa. Effective patient care needed inter-professional teamwork in receiving updated medication knowledge from the part-time pharmacist in the primary care unit. Communication skills helped the pharmacist provide effective resolutions to drug-related problems (DRPs). In phase 2, the prospective, quasi-experimental study aimed to examine DRPs, blood pressure control, and physician acceptance to pharmacists’ roles, as well as, to examine relationships of patient’s or pharmacist’s factors with the effective resolutions to DRPs. Data collection form of DRPs was adopted from Cipolle et al’s classification. Quantitative data collection was performed on 1,471 hypertensive patients who were attended consecutively 3 visits by the pharmacists participated in the phase 1. Of all 379 DRPs identified, the highest problem was 164 of non-adherence (43.3%). After the primary pharmacy care, the DRPs were significantly decreased by 33.2% and 32.4% (c2(2)=46.78, p < 0.001) at visit 1 and 2, respectively. Blood pressure was unchanged. Physician acceptance rates to pharmacists’ roles were 77.8%, 70.3% and 68.4% consecutively. The factor related to the effective resolving non-adherence was the physician acceptance (rs = 0.18, p = 0.020), consistent to phase 1’s findings. This sequential embedded mixed-method research provided linkages of all findings which clearly illustrated the overview duty of primary care pharmacy.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: The Development of Telemedicine for Caring Patient undergoing Peritoneal Dialysis: Lesson Learned from the COVID-19 Pandemic 
abstract:Background and rationale: Chronic kidney patients with renal replacement therapy were at risk of COVID-19. During COVID-19 pandemic with social distancing practices, hospitals postponed patient’s appointments. Methodology: The purpose of this mixed-method study was to develop and examine the effectiveness of telemedicine model in caring for peritoneal dialysis patients from lessons learned during the COVID-19 pandemic. The samples included 2 nephrologists, 6 pharmacists, 10 peritoneal dialysis nurses, and 80 peritoneal dialysis patients. Purposive sampling was used to select the participants. The study comprised 3 phases: phase 1 situation analysis; phase 2 design and development of a model of telemedicine service for peritoneal dialysis patients; and phase 3 result study of the telemedicine model by comparing the treatment time, cost and satisfaction. The research instruments covered a semi-structured interview guide, feasibility questionnaire of telemedicine model, cost record form, and satisfaction questionnaires for multidisciplinary team and peritoneal patients and caregivers. The quantitative data was analyzed using descriptive statistics, Wilcoxon signed-rank test, and paired t-test. Results: 1. During COVID-19 pandemic, patients and their caregivers have difficulty getting to the hospital as scheduled, the continuity of taking medication and the limitation of home visits. Patients and multidisciplinary teams suggested that during COVID-19, the methods of care should be adjusted, using telephone online platforms, such as Line application, to provide patients and caregivers the knowledge to promote self-care. The applications should be downloaded onto a mobile phone for immediate communication with the doctor and nurse when abnormal symptoms and problems were found. 2. According to patients and care providers, the feasibility of a telemedicine model in caring for peritoneal dialysis patients was moderate at the beginning. The model was rated highly by the multidisciplinary team, patients, and caregivers at the conclusion of the intervention. 3. Three patterns of patient journeys of peritoneal dialysis patients were identified based on clinical status of the patients: a well-controlled, a moderate control, and an uncontrolled symptom group. and 4. medication management of erythropoietin (EPO) and other medications for chronic kidney disease and co-morbidities were delivered through a nearby client hospital network. Discussion and conclusion: The cost of telemedicine model incurred higher capital costs at periphery. The higher number of services should lower the unit costs. Telemedicine was proved to be a feasible model of providing care among patients who had good disease progression control and reducing hospital visits. Therefore, the health service may develop and expand the results of this study to other chronic diseases. The provider should combine telemedicine with outpatient service.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Impact of COVID-19 Pandemic and Occupational Therapy Telehealth in the “New Normal” Situation 
abstract:This mixed-method study aimed to investigate the impacts of the coronavirus pandemic on occupational therapy (OT) services in Thailand and to explore the feasibility of adapting international service models into the Thai context from OT’s perspective. One hundred fifty-three occupational therapists were asked to complete the questionnaires, and 45 OTs were invited to participate in focus group discussions. The lockdown measures and the increasing number of COVID-19 patients in Thailand meant that rehabilitation services were classified as non-urgent. Many patients endured irregular service for an extended period affecting their recovery and performance. Three types of OT services were developed to deliver services in the “new normal” situation: on-site; telehealth; and hybrid. OTs redesigned the services according to patient demand and need: orofacial motor skill training; outcome measurement and follow up; home program counseling; screening and history taking; functional assessment and telephonic monitoring; Line application; material or equipment delivery to home; social skills group training as a hybrid service; and educational video production. OT telehealth remains a challenge for efficiency implementation. Policy recommendations include developing clinical practice guidelines for efficacious and cost-effective OT telehealth services. Upskilling and reskilling training courses should be available to occupation therapist. The government should provide telecommunication infrastructure for equal access to OT services to all who need.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Policy Recommendation Synthesis for Nursing Practice Workforce Development: Production, Distribution, and Retention due to COVID-19 Pandemic 
abstract:The purpose of this mixed-method study was to synthesize policy recommendations on nursing workforce development: production, distribution, and retention during the COVID-19 pandemic. The quantitative data were collected from 396 samples through the questionnaire on actual and expected workforce retention operations due to the COVID-19 pandemic. The qualitative data were collected from 120 subjects through in-depth interviews. The findings were as follows: 1) Pre-pandemic situations of production, distribution, and maintenance of nursing workforces relied on the production plans of educational institutions. The teaching style and the distribution of nursing profession were based on big hospital setting, and the maintenance of nursing workforce as a whole was inappropriate to workload. 2) During the pandemics, the production plan did not change. However, a variety of functions and skills needed to deal with changing situations were delivered through on-line and in class to learners to solve the skill shortage problems. The movements of trained nursing workforces to cover high nursing care needs at the primary, secondary and tertiary levels of field hospitals in the community up to the intensive units in hospital. Retention measures were found in various compensation plans appropriate to the increased burdens and risks. 3) Post-pandemic policy proposals for nursing workforce were on the production, distribution, and maintenance. On the production side, long-term production plans should take account of the actual needs of the country’s health service system. In terms of distribution, there should be a review and planning the distribution of nursing staff in health care facilities at the ministry level, regional health systems and health care facilities at all levels systematically to have appropriate number of workforces according to geographical contexts, population health needs and levels of nursing services complexity. In terms of workforce retention, guidelines should be developed for building nurses morale and motivation.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Thailand’s Global Movement on Mental Health 
abstract:In the situation of the COVID-19 pandemic, people were stressful due to the impact on social, economic and health situation from the pandemic. As a result, the number of people with mental health problems and the burden of mental health problems has been increasing. Recognizing the importance of mental health issues during the COVID-19 pandemic, Thailand proposed a mental health preparedness and response for the COVID-19 pandemic as the agenda of the 148th session of the World Health Organization Executive Board and played a leading role in developing a decision on this issue with supports by many countries. Thailand’s movement on mental health was the result of close collaboration between different organizations, continuous investment on capacity building of potential global health personnel and a strong network with countries and the WHO. Therefore, what Thailand has gained from driving mental health issue on the global platform is building a positive role and image of Thailand, incorporating Thailand’s interest into a decision and adapting lessons from other countries on mental health into Thai context.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: 13 Years - Learning and Development of Stroke Fast Track in Thailand 
abstract:The National Health Security Office (NHSO) has encouraged the free treatment of patients with acute ischemic stroke with thrombolytic treatment starting in 2008 only at university hospitals in Greater Bangkok. Subsequently, the aforementioned treatment services have been expanded to all areas in Thailand. The challenge of such treatment is that the time from the patient’s neurological symptoms until receiving thrombolytic treatment must be within 270 minutes as soon as possible. A shortage of neurologists in the provinces challenged the development of stroke service network. Using the principles of NETWORK (N: national standard, E: engagement, T: teamwork, W: wisdom, O: organization, R: reach target, K: knowledge management) and STANDARD (S: seamless, T: timeliness, A: awareness, N: network, D: drug available, A: ability, R: referral system, D: district health system) enabled nationwide service expansion in 2011. The current rate for acute ischemic stroke patients with thrombolytic treatment was approximately 8%.
location: nan, 'Thailand 
year: 2023 source: HSRI 
title: Feasibility and Acceptability of Health Maintenance Organizations for Medical Care Service under the Social Security System: Policy Research 
abstract:Health maintenance organization (HMO) is one of interesting models for responding to Social Security Office’s (SSO) medical service developments. Therefore, feasibility and acceptability of stakeholders were needed to be studied for further planning decisions. Methodology: This policy research study was to assess the feasibility and acceptability of three proposed HMO models with the SSO transforming into supervisory and monitoring roles. Model one was the HMO through a large private hospital network; model two, HMO through the public health insurance or regional health system; and model three; HMO through a private insurance company. Four key informants groups were selected by using purposive sampling including 1) policy executives serving as HMOs, 2) service providers, 3) service users, and 4) executives or experts with relevant roles. Qualitative data were collected, and content analysis was performed. Results: HMO model two was the most feasible model regarding service area coverage, economies of scale, experiences of management and credibility, etc. However, there were other challenges such as regional health system capacity. Stakeholders concerned that insurer’s overhead cost would take away the desirable benefits of service users, especially in private HMOs that might have a for-profit culture. Some opinions suggested on more precise improvements of the current system instead of establishing HMOs. In addition, they disagreed on the sub-district health promoting hospital acting as gatekeeper at primary care level, as this would deprive user’s rights and create barrier of access to health services. Conclusion and discussion: Although the proposed HMO model two was considered the most possible, skeptics were on limited competitions within the HMOs. HMOs might not reduce the health expenditures because of overhead cost and long-term investment in primary care system. Further study should consider possible competitive HMO models or other HMOs in Thailand such as medical schools network.
location: nan, 'Thailand 
year: 2022 source: HSRI 
title: Development of Health Workforce Registry and Data Sharing Platform Between Professional Councils and the Ministry of Public Health for Comprehensive Health Workforce Planning and Management in Thailand 
abstract:This study focuses on establishing health workforce data sharing platform between health professional councils and the Ministry of Public Health. Minimal dataset adopted from WHO’s recommendation was created. This standard dataset was agreed by all health profession councils according to Thai’s context. This essential data for each health profession is basically required for planning and management for national and organization level. International definition was kept in mind for future global comparison. Essential personal data includes personal identification number, name and surname, birth history information, current address, contact information, and a professional license. Certification of education and training, employment status, and address of the place of employment. Moreover, the centralized platform has been created to facilitate the collection of data for supervision, monitoring, evaluation, and research between related sectors particularly health professional councils and the Ministry of Public Health. Establishing of a data link and personnel registration system Establishment of a system for registering professional personnel It complies with several operational standards regarding hardware equipment, software, and adequate vocational training. And data storage is mandated by law. The main result aims to strengthen the national health workforce core indicators to facilitate policy makers to establish proper plan, effective management, and good monitoring system on health workforce both national and sub-national level