plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Types of Wounds and Patterns of Antibiotic Use in Trauma Patients in Mahasarakham Hospital 
abstract:In 2016, Ministry of Public Health’s service plan included antibiotic use in traumatic wound patients as an indicator of rational drug use. The target of this indicator was set at <40% based on a study in one large university hospital. Little is known on antibiotic use particularly in other hospital levels and regions. The objective of this study is to describe types of wounds and patterns of antibiotic use in traumatic wound patients. A prospective study was conducted in emergency unit, Mahasarakham Hospital during 1 March to 30 April 2018. The study measured types of wounds, wound classification according to antibiotic use guideline (antibiotic use is recommended for only class 2 and 3), prevalence of antibiotic use, type and duration of antibiotic use, and proportion of appropriate antibiotic use according to the guideline. Of total 267 patients, most of them were male (51.7%), had no co-morbidity (75.3%) and average age of 34+21 years. Median time from injury to hospital was 1 hour (IQR: 0.3, 3). The most common location of wound was at leg (32.2%) and wound type was animal bite (55.1%). Wound contamination was 74.5%. Prevalence of antibiotic use was 65.5%, when stratified by wound classification the prevalence was 11.1% in class 1, 72.2% in class 2 and 87% in class 3. The most common antibiotic use was Amoxycillin (62.9%). Average duration of antibiotic use was 5+1 days. According to the guideline, the rate of appropriate antibiotic use was 86.5% and appropriate duration of antibiotic use was 65.9%. In conclusion, use of antibiotics in traumatic wounds in Mahasarakham Hospital mostly adhered to the guideline but was higher than the target. Ministry of Public Health should reconsider the target of this indicator and promote further study in various hospitals and regional settings for appropriately reflecting quality of care.
location: nan, 'Thailand 
year: 2018 source: HSRI 
title: Evaluation of probiotic product for prevention of dental caries in young children 
abstract:Background: In our previous clinical study showed that probiotic Lactobacillus paracasei SD1 was safe, and the strain could reduce salivary cariogenic mutans streptococci resulting in reduce caries progression in volunteers by receiving everyday milk powder containing probiotic L. paracasei SD1. Aims: This continued study aimed to examine the efficacy of caries prevention by receiving probiotic milk powder every day, 3 days/week compared to normal milk (without probiotic). Methods: The study designed as randomized double blind controlled trial taking 1 year of monitoring. After consented, all participants have been randomized into 3 groups including: probiotic group who received probiotic milk every day, mixed group who received probiotic milk 3 days a week and control group who received milk without probiotic every day, 3 grams for 6 months. All participants were monitor at baseline (T0), 6 (T6) and 12 (T12) months for caries status, salivary immune, human neutrophil peptides (HNP) 1-3 by ELISA kit, and bacterial levels (total lactobacilli, L. paracasei/L. casei and S. mutans) by real time PCR. Results: It showed that probiotic L. paracasei SD1 could prevent caries progression and promote regression among children who received probiotic milk either every day or 3 days/week compared to control group. This is the results from the findings of reducing of cariogenic S. mutans and stimulating of salivary immune HNP 1-3 among children who received probiotic milk either every day or 3 days/week compared to control group. In conclusions: Results of study indicated that the consumption of probiotic milk either every day or 3 days/week could prevent dental caries. However, it noticed that salivary immune HNP 1-3 level was significant higher in children who received probiotic milk every day than in children who received probiotic milk 3 days/week, which may effect on caries prevention in long term. This study provides information that may be useful for administration of giving probiotic L. paracasei SD1 to prevent caries in young children.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Performance and Roles of Family Physicians: Synthesis of Policy Recommendations 
abstract:Background This study aimed to synthesize policy recommendations for future planning in family physician training and effective primary care cluster policy implementation with regards to actual needs and responsive to the situation Methods Situation review and value chain analysis were done in 8 primary care clusters in Central, Eastern, Southern, and Bangkok Metropolitan areas in 2018. A national survey in all 13 health services areas was deployed during the second and the third trimesters of 2018 in order to assess major stakeholders’ perceptions and opinions; including administrators, academics, and family physicians, on national primary care cluster policy implementation as well as the performance and roles of family physician in their settings. The data from primary and secondary sources were analyzed and policy recommendations were synthesized accordingly. Results 213 subjects were participated in the study. 50.7% was female, and median age was 38 years (range 24-84 years). Regarding performance and roles, all groups of the stakeholders indicated that expectable performances of family physicians had not been achieved yet in accordance with 6 performance dimensions of Royal College of Family Physician of Thailand. For primary care cluster policy implementation, there were significant hurdles from frequent changes in policy contents, unclear messages, incongruencies with community situation, rigid specifications, lack of positive retention strategies on healthcare personnel, misunderstanding and acceptance problems among healthcare professionals as well as community, imbalance between demand and supply, lack of policy advocacy at local areas, and problems in family physician training system including trainers, trainees, and related resources. Policy recommendations 1) The Ministry of Public Health should allow those in local areas to propose their own operation plans as well as appropriate and feasible performance indicators. 2) The Ministry of Public Health should modify their policy contents by allowing any physicians to perform as family physician without the necessity to train in family medicine program. 3) The Ministry of Public Health in collaboration with the Royal College of Family Medicine of Thailand and other related Royal Colleges should develop self-directed learning system for the physicians and other health professionals to gain knowledge and experience in family medicine. 4) The Ministry of Public Health in collaboration with the Royal College of Family Medicine of Thailand and other related Royal Colleges should discontinue their diverse approaches in family medicine training, and preserve only a standard training program. Moreover, they should develop specialty training programs that are in needs for the society such as longterm care, elderly care, etc. 5) The Ministry of Public Health should develop networking system in the local areas that can effectively link specialists with family physicians by using “Shared care and responsibility”.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: The Reform of Thailand National Security of Drugs and Medical Supplies 
abstract:At present, the management of drugs and medical supplies in the emergency is not very efficient. In addition, Thailand very much relies on the importation of drugs and medical supplies in the normal circumstance. This research study aims to review and analyse the management situation of drugs and medical supplies and to propose the recommendations to reform the management of drugs and medical supplies for Thailand in emergency and at normal situation. This study was designed as a qualitative study. The data was collected using qualitative approaches including the literature review, focus group discussion with stakeholders, in-depth interview with experts and Delphi Technique. The study revealed that to reform the system towards the goal of drugs and medical supplies security in the emergency, the national master plan is needed. There is also a need to assign Division of Public Health Emergency Management (DPHEM), Office of the Permanent Secretary, Ministry of Public Health to be the focal body with the aim to integrate and cooperate with all other related agencies. The Information and Communication Technology Center should be assigned as the main responsible organization in the reform of the IT system. In addition, the study also indicated that the national list of drugs and medical supplies to be reserved, the quantity to reserve should be determined using the scenario planning technique. Moreover, a new law specific to the management of drugs and medical supplies in the emergency should be developed to enhance the efficiency of the management system. Regarding the self-reliant capability, the study indicated that the reform should first start with fast re-structuring of the existing organizations which are responsible for the improvement of drugs and medical supplies industry and reviewing of their roles and responsibilities to put special focus on drugs and medical supplies. The approaches to reform should be performed throughout the entire supply chain. Furthermore, it is really essential to change the budgeting system and unite the working mechanisms among related authorities. Reduction of selling privilege of the Government Pharmaceutical Organization and other organizations which have similar privilege, aiming to create equity and enable real market competition, is one of the main findings from this study. The government should also support the budget to drugs and medical supplies industry to facilitate more efforts and investment in research and development and production, To conclude, the government should place as much emphasis as possible on this reform. Extensive effort should be carried out to facilitate the system reform. The focal authority should be strengthened on every aspect thus the actual integration could be established and the security of drugs and medical supplies of Thailand could be expected.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Development of Multidisciplinary Care Model for Outpatients with Chronic Heart Failure 
abstract:Heart failure (HF) is a major health problem globally. Multidisciplinary team care increases standard medication treatment, decreases risk of hospitalization with heart failure and all-causes mortality, also improve quality of life in patient with heart failure. However, with the increasing of number of patients and lacking the clinical practice guidelines in the HF clinic, are affecting the problems of data management, redundancy of documentation. These are obstacles for data management in patient care, quality assurance and initiating of academic work. This is a participatory action research among staffs inside the HF clinics and outside the HF clinic, also patients or care givers. The objectives of this study including the development of multidisciplinary care model and the clinical practice guidelines for HF patients in the clinic, the development of data management system and other tools, and the comparisons of outcomes between before-after receiving care from the HF clinic The results from problem survey found that problem related to data management was the most important including data collection, documentation and report, redundancy of data documentation and communication within the clinic. The patient’s data-base system was developed, as well as the clinical practice guidelines and other tools for supporting patients’ care. A total of 100 patients, 58.00 percent were male, the mean age of 6 1 . 9 2 + 1 5 . 7 5 years old. Patients received treatment in the HF clinic for at least 6 months. The mean of ejection fraction (EF) was 30.80 + 8.48 %. The common cause of cardiomyopathy (CMP) was ischemic CMP (70.00%). The evaluation of all process outcomes found improved significantly including patient’s knowledge for self-care score, the mean guideline adherence indicator (GAI) increased from 64.35 + 38.25 % to 88.50 + 21.76 (p=0.009), the New York heart association functional class was improved, and also the 6-minute walk test. All drug related problems (DRPs) found were 134 problems. The common DRPs were dosage too low (47.00%), non-compliance (37.00%), and adverse drug reactions (21.00%). The DRPs were solved mostly by physicians adjusted the medication combined with pharmacist provided counseling to patients (61.94%). The majority of DRPs were solved completely (70.00%) with 29.00 percent were pending for following-up. The outcomes after development of patient’s care model resulted in the numbers of hospitalization with heart failure decreased significantly (33.0 and 8.0%, p<0.001) and saved the total of hospitalization cost 8,839.72 baht per patient, the quality of life score increased significantly, and the mean patient satisfaction score was in the level of good-best after received the developed patient’s care system.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Good clinical practice guideline in patients with arteriovenous access phase2 
abstract:Background: Based on national and international guidelines (Kidney Disease Outcomes Quality Initiative-K DOQI) in patients with end staged renal disease, arteriovenous access (AVA) creation without history of central venous catheter (CVC) insertion is the recommended approach, but in Thailand, most hemodialysis patients had experiences of CVC insertion beforehand. Underestimation of consequences of such approach in our patients and medical personnel, might be a cause. Therefore, we aimed to develop the protocol that can improve the outcomes. Methods: Expressed Protocol in Northern Thailand (EPNT) was formulated. EPNT was composed of: 1) patients who did not have any experience of CVC insertion before AVA creation, 2) patients almost used vein for AVA creation, 3) AVA was under good surveillance after operation. This study plan followed up in 24 months, but this report compared and illustrated the outcome between EPNT and non-EPNT patients in the first 15 months. The outcome included the rate of maturation, AVA complications, central vein stenosis, sepsis, major adverse cardiovascular event (MACE), and the score of Quality of life by SF-36. Results: There were 100 EPNT patients and 101 non EPNT patients. EPNT group had lower cumulative rate of AVA infection (EPNT: 0% vs non EPNT 2.52%, p = 0.087), than those in non EPNT. Also 11.9% in non EPNT patients had history of CVC sepsis. EPNT group had lower rates of central vein stenosis (EPNT: 1.23% vs non EPNT 5.11%, p = 0.146), than those in non EPNT group. However, these trends did not reach a statistically significance. The rates of maturation, AVA complications, and MACE were not different between two groups. The score in the general mental health in EPNT group was significantly better than those in non EPNT group. Conclusion: EPNT patients had a trend toward lower rates of sepsis and central vein stenosis, and better general mental health scores than those non EPNT patients. However, this 15-month result does not make any solid conclusions to determine the difference between EPNT and Non-EPNT. Further results will shed more light on this field.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Discovery of novel and highly selective anti-TB agents with activity against drug-resistant TB infections 
abstract:Tuberculosis (TB), an infectious disease remains a major public health concern in Thailand. This research, we focused on design and discovery of potent anti-tuberculosis agents to overcome fluoroquinolone drug resistant using molecular modeling, computer aided molecular design approaches combined with biological assay evaluations. In order to design and develop structure of DNA gyrase inhibitors targeting at ATPase domain of DNA gyrase subunit B including 4-aminoquinoline, 4-(piperazin-1-yl)quinolone, 2-(1H-benzo[d]imidazol-2-yl)-2-cyanovinyl, Nitro-thaizole and benzo[d]isothiazole derivatives, molecular docking calculations, quantitative structure–activity relationship (QSAR), molecular dynamics (MD) simulations and FMO calculations were performed. The crucial interactions in ATPase domain and structural requirement of inhibitors revealed the key information for ration design highly potent DNA gyrase inhibitors.  Virtual screening and biological assay were applied to discovery of novel and highly potent DNA gyrase inhibitors. 17 compounds showed the inhibitory activity based on ATPase assay closed to reference compound, Novobiocin. For antimicrobial assay, two active compounds, G24 and G26 were obtained the 12.5 µg/ml. DNA supercoiling assay of active compounds in wild-type and N538D mutant type of DNA gyrase were investigated. The obtained results showed that the inhibitory activity of two compounds (G18 and G24) were higher potent than the reference drug, ciprofloxacin. There active compounds (G18, G22 and G24) showed the DNA supercoiling inhibition higher than the reference drug. Pharmacokinetic properties of active compounds were predicted using ADMET predictions. The obtained results revealed that new active compounds were suitable for structural modification to improve the biological activity. MD simulations and X-ray crystallography were used to investigate the binding mode and binding interactions of active compounds in ATPase domain. The obtained results provided the crucial interactions for developing novel and highly potent compounds for fluoroquinolone drug resistant tuberculosis.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Development of genome-based analysis platform and identification of genomic markers for epidemiological investigation and prediction of drug resistance in Mycobacterium tuberculosis (Year 2) 
abstract:Tuberculosis (TB) remains a public health problem in Thailand and causes socio-economic consequences. Studying of epidemiology and biology of Mycobacterium tuberculosis, a causative agent of TB, development of rapid diagnosis of drug-resistant TB, and effective treatment are urgently required for effective prevention and control of TB. Genotyping of M. tuberculosis strain based on specific genomic markers has been widely used for epidemiological study. Particularly, single nucleotide polymorphisms (SNPs) are current genomic markers appropriate for epidemiological and evolutional study and also for prediction of drug resistance. From the first-year study, we could develop the whole genome sequence analysis pipeline for prediction of resistance to first-line anti-TB drugs (isoniazid, rifampicin, streptomycin and ethambutol) and for rapid genotyping. Comparison with results obtained from standard drug susceptibility testing, the analysis pipeline had sensitivity and specificity of 94.6% and 98.5% for isoniazid, of 92.4% and 99.6% for rifampicin, of 85.3% and 98.9% for streptomycin, and of 66.7% and 97.9% for ethambutol, respectively.  For genotyping the pipeline showed 100% concordant results with the standard LSP. In addition, SNPs databases for drug resistance and genotyping were created from this study. In the second year of the study, the automatic genome analysis pipeline for prediction of drug resistance and for genotyping was developed and validated with a test sample set of 50 M. tuberculosis strains comprising of 41 isoniazid-, 43 rifampicin-, 23 streptomycin-, 27 ethambutol-, 12 amikacin-, 13 kanamycin-, 25 fluoroquinolone-, 11 ethionamide- and 15 PAS-resistant strains. Results were compared with those obtained from the standard drug susceptibility testing and revealed the sensitivity and specificity from 82.6 to 92.6% and from 87.0 to 100%, respectively, for prediction of first-line anti-TB drugs. The sensitivity was lower for prediction of second-line drugs; sensitivity and specificity ranged from 66.7 to 80.0% and from 92.0 to 100%, respectively. The automatic genome analysis pipeline also showed 100% concordant results with the standard LSP for genotyping.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Invention of an Instrument for Balance Assessment and Feedback (2nd year) 
abstract:The present study was invention of an instrument for balance assessment and feedback in second year. The purpose of this research was to test the efficiency of the instrument by testing reliability. Forty-two participations, aged range 40-93 years, were recruited into this study. Participants were divided into two groups, including aging group (n=22) and people with stroke group (n=20). The finding showed that reliability of force measurement was very high for both plates (ICC (3,1) = 0.945 for plate 1 and 0.978 for plate 2, p<0.000) in aging group, while reliability of force measurement in people with stroke group was between high and very high (ICC (3,1) = 0.872 for plate 1 and 0.968 for plate 2, p<0.000). Reliability of center of pressure was between middle and high in both groups. In conclusion, the instrument was able to measure force efficiently. However, this instrument should be developed in order to increase effectiveness of measuring center of pressure.
location: nan, 'Thailand 
year: 2019 source: HSRI 
title: Development of detection of circulating tumour cells in peripheral blood using magnetic cell isolation method in   combination with fluorescently labeled antibodies to detect cancer cell antigens 
abstract:The present study was aimed to develop a method to detect cancer cells in venous blood of cancer patients, either for screening for following-up. Heparinized venous whole blood of about 10 milliliters from the subjects were processed for red blood cell lysis and white blood cell depletion. The cells remained were cryo-fixed and stained using commercially available reagents claimed to give a good morphology of the fixed cells that could be stored for many months. Blood samples were collected from 25 colon cancer patients and 12 subjects who were negative for colon cancer screened by colonoscopy. Early in the study, blood samples from 2 breast cancer patients, 5 hepatocellular carcinoma patients, 1 cholangiocarcinoma patient, 1 lung cancer patient and 1 osteosarcoma patient were also collected. Antibodies against vimentin, cytokeratin, CD45, CDX2, CD31 and CD34 were used. Due to a technical problem on red blood cell lysis and staining temperature, a few weeks were spent to solve it and later cells could be fixed and stained at low temperature. Other optimizations included low temperature handling steps and concentrations of antibodies. The immuno-stained cells appeared mostly to be white blood cells of good morphology. A pathologist had investigated the stained samples and found that there were only 2 cases out of 25 colon cancer patients that seemed to have some abnormal/cancer cells. These were larger and their neclei were also bigger than the nearby white blood cells. They were especially positive for CK 20 and CDX2, the latter being reported to be specific for adenocarcinoma. However, the size of many abnormally stained cells found in many cases was similar to white blood cells, it may be concluded that in this present study abnormal cells could be found in blood samples of colon cancer patients but perhaps with a very low sensitivity. Also owing to quite a high cost of reagents for cell isolation and low temperature processing, this method at the moment could not be used as a routine colon cancer screening.