plueme/wizJson huggingface dataset:
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Who Achieved 60 Kilometers in 60 Days of the First Thailand National Steps Challenge? A Cross-Sectional Study of Thai Adults 
abstract:Thailand had implemented the first national steps challenge in 2020 by Ministry of Public Health with the goal to achieve the distance of walking and running at 60 kilometers in 60 days during 1 February to 31 March 2020. The challenge aimed to increase awareness on physical activity at country-wide level. This study aimed to determine the achievement of 60-km goal of Thailand steps challenge season 1. Website-based data of 203,910 records, of participants who sent distance data, was retrieved and analyzed by descriptive parameters and logistic regression. The achievement of accumulative distance of at least 60 km was analyzed by participants’ demographics such as sex, age, body mass index, region, urbanity, and type of participant. The findings revealed that around 46% of participants, who sent distance data, achieved the project goal. Men achieved the goal higher than women. Participants aged 30-59 years, not being obese, living in Bangkok, living in urban areas, and being public health officers, achieved the project goal higher than their counterparts. Being obese, living in rural areas, and being village health volunteers, were less likely to achieve the project goal (adjusted Odds ratio = 0.89, 0.83, 0.43 by multivariate analysis, respectively). The study recommended that the national steps challenge should be continuously implemented by using more strategies to engage participants with different characteristics throughout the project.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Research for evaluating the impacts of medical marijuana policy in Thailand, Phase I 
abstract:The medical marijuana (MMJ) system has been established for the first time in Thai history since February 19, 2019, according to the Narcotic Control Act 2019 (7th edition) . This study aimed to find essential research questions regarding the implementation and impacts of and design the monitoring and evaluation system for the MMJ policy in Thailand. Research methods employed include a literature review, 22 in- depth interviews with key stakeholders, two focus group interviews covering nine service providers and patients, and a participatory observation in the MMJ clinic at the Ministry of Public Health. Our crucial findings cover: (a) the Thai MMJ system is complex, consisting of the sub-systems: modern medicine, Thai traditional medicine, and local community medicine. These three sub- systems are not harmonized. Patients could not access and benefit from the whole system, resulting in many of these patients having to use illegal marijuana products. ( b) MMJ is a new matter in Thailand and could provide both benefits and drawbacks for the Thai society; hence it is essential and urgent for Thailand to have an MMJ related knowledge generation system and an MMJ policy impact monitoring and evaluation system. (c) MMJ movement in Thailand has attributes like “political economy,” which means the MMJ policies may be driven by benefits rather than medical rationale. The proposed policy recommendations include follows. (1) Establish an advisory committee containing various capability dimensions and socially accepted, and have no conflict of interest. (2) Strengthen the MMJ service system in a way incorporating the advantages of all three MMJ sub-systems. (3) Urgently invest in the policy impact monitoring and evaluation system, including evaluating the supply, service utilization, and short-term and long-term consequences. (4) Promote Thai people’s health literacy regarding MMJ is crucial to prevent them from being victims of false information of the illegal MMJ providers. (5) Study the efficacy and the cost-effectiveness of various MMJ products in Thailand using the Thai culture-relevant, modified scientific method. And (6) study future MMJ policies for Thailand to inform policy decision making guided by scientific evidence.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Development of lung model by using a 3D cell culture model for COVID-19 drug development 
abstract:The current situation of the SARS-CoV-2 virus infection causing COVID-19 is more serious. The development of antiretroviral drugs is urgently important. To stop the spread of the virus, the lungs model is critical to develop of antiretroviral drugs. Due to, SARS-CoV-2 relies on the Angiotensin-converting enzyme 2 (ACE2) target receptor protein, which is more common in lung cells, and caused of pneumonia. Thus, the focus of this research is to develop a lung model to study the mechanism of viral infection and develop the treatment of COVID-19, because of it is difficult to study biopsy samples from infected people. The aim of this research project is to simulate lung tissue structures using a technique as the Air-liquid interface to create conditions like the pulmonary scaffolds with ACE2 receptor protein expression. Development of therapeutic and drug testing guidelines for COVID-19. The experimental results in two-dimensional A549 lung cancer cells that were induced inflammation by lipopolysaccharide (LPS) was found the highest protein concentration of 0.2 micrograms per microliter. The nitric oxide measurement was observed in LPS-stimulated samples for 24 hours. Inflammation was observed with low nitric oxide about 2 µM, while the three-dimensional with LPS and hydrogen peroxide (H2O2) stimulation, the nitric oxide was not detected. As for the expression of ACE2 receptor that analyzed by Western blot method, the result can be found at approximately 97 kilodalton (kDa) size of the ACE2 receptor. Consequently, the lungs cancer cell line A549 in three-dimensional Air-Liquid Interface was expression ACE-2 receptor. However, the experiments also need to be repeated in the analysis of ACE2 and AT1R expression and control as beta-actin with western blot, and further at the gene level through qPCR analysis in a two-dimensional versus three-dimensional model. To determine the difference in receptor expression in inflammatory stimulation. The model will further investigation of the substance and the stimulation concentration was selected with spike protein instead for stimulation. The antioxidant was measured, and nitrate content will detect inflammation by LPS and H2O2. The problems that cannot trigger inflammation. So, the experiment still needs quality testing and test the concentration of the substance again.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Knowledge information in scientific research of virus, diagnostic, treatment and vaccine development 
abstract:There was an outbreak of SARS-CoV-2, a novel coronavirus, in late December 2019, originated in Wuhan, China. The virus causes problems with the respiratory tract. The syndrome is called "COVID-19". The number of infections and mortality has increased in China within a few weeks after the first patient was discovered. The virus quickly spread globally, including in Thailand. Fortunately, Thailand has an excellent public health policy for handling the outbreak. So we could control the first wave of the epidemic by reduced the infection rate to zero for several months. However, the health systems research institute (HSRI) is looking forward to finding the research direction of COVID-19 for the country. Therefore, this project was funded to review the essential knowledge about the COVID-19 and SARS-CoV-2 for HSRI. The review will be used as basic information for making a policy and manipulating COVID-19 granting in the future. The investigators reviewed the general knowledge of the SARS-CoV-2 that was a causative agent of the COVID-19. The report is divided into five chapters, where Chapter 1 addresses the basic biology of the SARS-CoV-2 virus, including taxonomy, virus structure, genome structure, viral proteins, and virus life cycle. Chapter 2 describes the diagnosis of infection by different test kits. The investigators have identified the key points of the different test kits, the limitations of the use of the diagnostic kits and their interpretation. Chapter 3 summarized all five major types of SARS-CoV-2 antiviral agents, which is currently used. The five grooups of antiviral drugs are (i) anti-enzyme activity of RNA Dependent RNA polymerase (RdRp), (ii) protease inhibitor, (iii) anti-fusion between the viral envelope and the host cell membrane, (iv) the antagonistic binding activity between the virus and host cell surface and receptors, and (v) anti-interleukine-6 receptor. Chapter 4 is focused on the immune system responding to SARS-CoV-2 virus infection. Chapter 5 will address the opinions of researchers, who are working on COVID-19 research over time of outbreak. The investigators wish the information of this report would be helpful for HSRI to be used in country policy-making for COVID-19 funding.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Thai National HRH core Indicators 
abstract:The objectives of this study are to develop Thai Human resources for health (HRH) core indicators including the data standardization and related organizations and to propose policy recommendations to establish these indicators. Indicators engage comprehensive health labour market framework; such as education and labour market dynamics. Study’s method includes literature reviews and key informant interview. Multi-stake holders committee under Ministry of Public Health is established to be a policy platform to implement this indicators. The result shows there are 17 HRH core indicators for Thailand categoried into 4 groups, 6 indicators for HRH production, 1 indicator related HRH professional registration, 9 indicators related to health labour market including distribution, retirement and retention and 1 indicator for unit cost on the health workforce production. In term of data completion of each indicator, this study shows that only 7 indicators, namely number of faculties and production capacity, graduation rate, rate of passing licensing examination, number of foreign-trained and foreign-born, accreditation system and continuous professional development system, are completed and ready to report. Data completeness and the linkage system between data source are the main problems to report the rest indicators. Three important measures recommended for policy makers to implement Thai HRH core indicators are 1) Strengthening HRH registry 2) Establishment HRH data platform among related sources and 3) Conducting systematic researches on HRH loss rate and unit cost of production.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: An early health technology assessment of COVID-19 vaccines: data for vaccine selection and targeting to maximise public health impact in Thailand 
abstract:Thailand is facing the dilemma of which groups to prioritise for the limited first tranche of vaccinations in 2021. A mathematical modelling analysis was performed to compare the potential short-term impact of allocating the available doses to either the high-risk group (over 65-year-olds) or the high incidence group (aged 20-39). Vaccinating the high incidence group with a vaccine with sufficiently high protection against infection (more than 50%) could provide enough herd effects to delay the expected epidemic peak, resulting in fewer deaths within the 12-month time horizon compared to vaccinating the same number of the high-risk group. After 12 months, if no further vaccination or other interventions were deployed, this strategy would lead to more deaths. With the right vaccine efficacy profile, targeting the high incidence groups could be a viable short-term component of the Thai vaccination strategy. These results and emerging evidence on vaccines and susceptibility suggest prioritisation guidelines should be more nuanced.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Questing for Sustainable Fiscal Space of Universal Health Coverage and Simulation of Health Worker Network Redistribution 
abstract:Objectives of this study are to (1) estimate fiscal space for universal health coverage (UHC) in Thailand, and (2) investigate the demand-supply gaps in health workers and develop microsimulation models to examine how to improve the allocation of health workers in the same areas. The study on health fiscal space found that the public budget for the Universal Coverage Scheme (UCS), when compared with the national goals of Sustainability, Adequacy, Fairness, and Efficiency (SAFE), tends to be neither sustainable nor adequate in the next ten years. This study also conducted quantitative analysis on three options to integrate the three schemes of UHC, which could reduce public budgets and improving fiscal efficiency. In addition, the political economy analysis indicates that there are possibilities to expand sources of funds such as earmarked VAT and tax reform for universal social welfare. The political movement is necessary to actualize the revenue and budget expansion. The study of area-based network allocation focuses on the hospitals under the Office of Permanent Secretary of the Ministry of Public Health and extends to the public-private partnership analysis. The basic results show that healthcare networking combined the primary hospitals and the first--secondary and middle-secondary hospitals within each district could alleviate workforce shortage. Furthermore, the provincial networking of the secondary and tertiary hospitals with the private hospitals which provide inpatient service could not significantly reduce workload per worker at the national average. However, when considered by province, the public-private partnership could reduce workload per worker by 10% or more in major provinces.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Migrant Worker Health Information System using GIS: Bueng Kan Province 
abstract:The two main purposes of this research were to develop the health information system using GIS program and evaluated for migrant worker in Bueng Kan province. And the second was to use this database system for related work department. The program was evaluated by 2 group of quality staffs, 6 experts and 20 other relevant officers. The evaluated program was test in 4 areas: functional requirement test, function test, security test and usability test. The statistic uses for analyze the data were mean, standard deviation (SD). The results were as follows: 1. Functional requirement test was good with mean 3.90 and S.D. 0.32 2. Functional test: good with mean 3.89 and S.D. 0.49 3. Security test: good with mean 3.92 and S.D. 0.62 and 4. Usability test: good with mean 3.89 and S.D. 0.29 In Summary, that means this program was quite good enough to use as a main database of migrant worker for most related work department at a 95% confidence level.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: The Efficiency of the development of the language coordinator in health insurance for foreign workers, Chiangrai Province 
abstract:A research study entitled “The Result of Capability Development of Language Coordinators' on Foreign Workers' Health Insurance, Chiang Rai Province” aims to provide foreign workers with access to health insurance by developing the capability of language coordinators on foreign workers health insurance and to provide foreign workers with knowledge of foreign labor health insurance. The samples were 120 language coordinators from Muang Chiang Rai District and Mae Sai District and a random survey of knowledge on foreign worker health insurance of 385 people. Survey tools used included general information query, before-after training knowledge quiz, knowledge evaluation form on foreign workers' health insurance, Supervising and tracking form as well as the collection of migrant worker’s health insurance registration statistics. Statistics used for analysis; descriptive statistics were frequency, percentage, mean and standard deviation, the inferential statistics are t-test. The results of the study showed that the capability development of the language coordinators in health insurance for foreign workers in Chiang Rai: starting with the survey of the language coordinators with required qualifications and setting up training sessions according to health insurance guidelines of the Ministry of Public Health. Most of language coordinators were 20-29 years of age, male, primary education qualification, freelance workers with monthly income from 5,000-10,000 baht, and were language coordinators based in Thailand for 5-9 years. Before the training, the language coordinators had a low level of knowledge and after the training they have a high level of knowledge. The test scores before and after the training were significantly different with statistical significance at the level of .05 After the training, the language coordinators' performance was monitored and supervised with result indicating that the most seek-for-advice topics were the benefits of health insurance, rates, required documents for health examination and health insurance, change of medical facility eligibility according to work location, and verification of health insurance eligibility. For the registration of health insurance of migrant workers, it was found that more foreign workers registered for health insurance cards after the development of capability of language coordinators. In assessing the knowledge of foreign workers on health insurance with the support of the trained language coordinators, it was found that foreign workers had a moderate level of knowledge of health insurance. The results of the research can be used to guide the development of language coordinators in other areas of Thailand. As a result, migrant workers have more access to health insurance.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: The Mobile Application for Standing Work Safety 
abstract:The purpose of this study was to develop a mobile application for standing work safety. The study process was divided into 3 steps including the determination of safe standing measures, the creating applications for standing work safety in the form of mobile application, and the trial programs created. The 180 standing workers participated in this study. Satisfaction and pain sensation in the calf and foot muscles were assessed after the trial run. The application can be installed through App Store in the IOS system and via the Play Store for Android users with the keyword "Safety Standing". The results of the study showed that the sample group was satisfied with the composition, and the usability of most programs is at a high level. After the trial run of the program, the feeling of calf pain was significantly reduced for 3 weeks and the sensation of foot pain was significantly reduced after just 1 week. Therefore, it can be concluded that the safety standing application in the form of a mobile phone application can help reduce pain in the calf and feet. As well as causing satisfaction in use that will result in the safety of the workers' standing.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Implementation of the Thai Diagnostic Autism Scale (TDAS) at Region 1 health Provider 
abstract:This research is applied research and aims to improve the training course administration
of Thai Diagnostic Autism Scale (TDAS) in the context of secondary and tertiary health care services and develop prototype models for implementing TDAS tools for useable innovations. The trial was conducted in 13 secondary and tertiary health care services with a sample size of 382 children between the ages of 12 and 48 months with suspected autism, found that 317 cases, representing 82.98 percent, had autism. All multidisciplinary staff, were found to have a very good level of post-training administration skills. Additionally, children at risk of delayed development in Expressive language (EL), Receptive language (RL) and Personal and Social (PS) ,results indicated that a delay in one of these domains had a statistically significant proportion of autism greater than 0.5 at the .01 level. At the secondary and the tertiary level, the multidisciplinary health care service teams prioritize centralized policy, leadership of the hospital director, personnel, and the multidisciplinary team. A major obstacle to providing local autism services is the waiting time for diagnostic services, continuing therapy. As well as the awareness and collaborative participation of parents. This research suggests the Ministry of Public Health that to simplify and shorten the waiting time for diagnose a child with autism, the revision of the care mapping of early childhood care is needed. As a result of the revision, a child can access the treatment process 6-12 months sooner than the present system allows.
location: nan, 'Thailand 
year: 2021 source: HSRI 
title: Identification of the involved factors and the underlying molecular mechanism rendering Mycobacterium tuberculosis Beijing strain ST10 Kanchanaburi which is the clonal outbreak MDR-TB strain to have special ability in causing high transmission rate and active MDR-TB in Thailand (2nd year) 
abstract:Tuberculosis is still a major public health problem in Thailand due to the increased incidence in drug-resistant and multidrug-resistant infections. From the study on multidrug-resistant tuberculosis in Thailand by using whole genome sequence analysis technique, Associate Professor Dr. Angkana Chaisprasert has discovered that there is a clonal outbreak strain in the Kanchanaburi Province (which is now referred to as the "MKR superspreader"). The MKR superspreader belongs to the Beijing family sequence type (ST) 10 genotype and is appeared to have a special ability to spread the infection when compared to that of other strains in Thailand. In this research, our team therefore aimed to identify the mycobacterial and host factors that contribute to the special ability of the MKR superspreader to transmit the infection better than other strains in Thailand. Since one of the main factors affecting the ability of Mtb to spread well from one patient to another depends on its ability to grow at a high rate in the host macrophages such that the host cells will die by necrosis, at which the bacteria will be released outside the cells. When the patient coughs or sneezes, the infectious aerosols will then transmit the Mtb to the other person. The higher the number of bacteria in the infectious aerosols, therefore, will increase the chance of infection to others. In this study, we hypothesized that the MKR superspreader has the special ability to transmit better than other strains because it has the ability to inhibit the defense mechanism of host cells resulting in high growth rate and causes the host cells to undergo necrosis. In year 1, we already confirmed that the MKR superspreader grew at a high rate in host macrophages and caused host cells to undergo necrosis when compared to the other strain. By conducting RNA-sequencing analysis, we also identifed host and mycobacterial genes that may contribute to the higher ability of the MKR superspreader to grow inside host macrophages and cause host cells to undergo necrosis. In year 2, we validated the expression of these genes by qRT-PCR as well as studied their function using the Crispr-dCas9 interference system (specifically developed for mycobacteria) and siRNA knockdown (for host cells) coupled with the phenotypic analysis. The results obtained led to the identification of new drug targets that can be further developed to be used to inhibit the infection by this strain in the future.