Aanal Bhatt
Senior Research Associate (iPSC Group) at Applied StemCell
Senior Research Associate at Applied StemCell
I'm an experienced research professional with a demonstrated history of working in the biotechnology industry. I graduated in 2018 with a Master of Science in Stem Cell Biology and Regenerative Medicine from  University of Southern California. Currently, I'm a senior research associate working primarily with genetically editing and characterizing iPSCs using CRISPR/Cas9 and cellular assays as well as reprogramming cells into iPSCs. I also have extensive experience in developing immunohistochemical, ELISA, and activity assays for AAV treated pre-clinical samples from my time at Applied StemCell, Inc.
Applied StemCell
https://www.linkedin.com/company/applied-stemcell
Senior Research Associate (iPSC Group)
San Francisco Bay Area
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Applied StemCell
https://www.linkedin.com/company/applied-stemcell
Research Associate (iPSC Group)
San Francisco Bay Area
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Applied StemCell
https://www.linkedin.com/company/applied-stemcell
Research Associate (Therapeutic Development)
San Francisco Bay Area
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Keck Medicine of USC
https://www.linkedin.com/company/keck-medicine-of-usc
Graduate Research Assistant - Ying Lab
Greater Los Angeles Area
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Harvard Medical School
https://www.linkedin.com/company/harvard-medical-school
Research Intern - Bonventre Lab
Greater Boston Area
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SRM University
https://www.linkedin.com/company/srm-university
Undergraduate Research Intern
Chennai Area, India
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The Maharaja Sayajirao University of Baroda
https://www.linkedin.com/company/the-maharaja-sayajirao-university-of-baroda
Summer Research Intern
Vadodara
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Master of Science - MS
University of Southern California
https://www.linkedin.com/school/university-of-southern-california/
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Bachelor of Technology (B.Tech.)
SRM University
https://www.linkedin.com/school/srm-university/
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Stromal-Cell Deletion of STAT3 Protects Mice from Kidney Fibrosis by Inhibiting Pericytes Trans-Differentiation and Migration
Cell Reports
Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis. Although Stat3 deletion in tubular epithelial cells is known to protect mice from fibrosis, vFoxd1 cells remains unclear. Using Foxd1-mediated Stat3 knockout mice, CRISPR, and inhibitors of STAT3, we investigate its function. STAT3 is phosphorylated in tubular epithelial cells in acute kidney injury, whereas it is expanded to interstitial cells in fibrosis in mice and humans. Foxd1-mediated deletion of Stat3 protects mice from folic-acid- and aristolochic-acid-induced kidney fibrosis. Mechanistically, STAT3 upregulates the inflammation and differentiates pericytes into myofibroblasts. STAT3 activation increases migration and profibrotic signaling in genome-edited, pericyte-like cells. Conversely, blocking Stat3 inhibits detachment, migration, and profibrotic signaling. Furthermore, STAT3 binds to the Collagen1a1 promoter in mouse kidneys and cells. Together, our study identifies a previously unknown function of STAT3 that promotes kidney fibrosis and has therapeutic value in fibrosis.
https://pubmed.ncbi.nlm.nih.gov/35263586/
Preclinical Development of ASC-618, an Advanced Human Factor VIII Gene Therapy Vector for the Treatment of Hemophilia A: Results from FRG-KO Humanized Liver Mice, C57Bl/6 Mice and Cynomolgus Monkeys
American Society of Cell and Gene Therapy (Abstract, 2020)
https://www.asgct.org/global/documents/asgct20_abstracts_may8?_zs=S2i4b&_zl=U9052
Site-Specific Genome Editing by CRISPR/ Cas9 for Hemophilia A in Human and NonHuman Primate Cells
American Society of Cell and Gene Therapy (Abstract, 2019)
https://www.asgct.org/global/documents/asgct19_abstracts_-final
Adeno-Associated Virus Serotypes Screening in Non-Human Primates for Hemophilia A Genome Editing Treatment
American Society of Cell and Gene Therapy (Abstract, 2019)
https://www.asgct.org/global/documents/asgct19_abstracts_-final
Long-term Culture Conditions for Hematopoietic Stem Cells
Role of STAT3 in Renal Fibrosis
17beta-estradiol Mediated Regulation of Antioxidant Status and Molecular Markers in the Thymus and Mesenteric Lymph Nodes of Middle-Aged Female Ovariectomized Sprague-Dawley Rats
Science and Technology
Graduate Women in Science
https://www.linkedin.com/company/gwis
Social Media Manager, Board Member
- Organized career development workshops as a part of the team
- Planned and organized for the March for Science (2018)
- Conducted other social events (mixers, networking lunches) for the chapter
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Science and Technology
Aaruush, SRM University
https://www.linkedin.com/company/aaruush-srm-ist
Student Volunteer
Volunteered for the annual, national level science and technology fest in SRM.
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Arts and Culture
SRM University
https://www.linkedin.com/company/srm-university
Student Volunteer
Volunteered for the annual national level cultural festival, Milan
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https://www.linkedin.com/in/brian-nelson-5b5aa862
Brian Nelson
Research Associate at Applied StemCell
Los Angeles, CA
https://www.linkedin.com/in/shreya-satagopan-915b8a39
Shreya Satagopan
Research Associate
San Francisco Bay Area
https://in.linkedin.com/in/kunal-arora-9291471b9
Kunal Arora
Research Scholar at IISER Bhopal, MP, India
New Delhi
https://www.linkedin.com/in/nicholas-borjian-08744aa0
Nicholas Borjian
Senior MSAT Specialist at Cellares
San Francisco Bay Area
https://in.linkedin.com/in/rashmi-naik-5b44b91b5
rashmi naik
Associate Research Scientist at Bugworks Research Inc.
Bangalore Urban district
https://uk.linkedin.com/in/dr-darshan-rudakiya-103a6412b
Dr. Darshan Rudakiya
Enthusiastic Senior Scientist who interested to work in Protein, Fermentation and Fungal biology.
London
https://www.linkedin.com/in/pruthvi-gowda-32a18b188
Pruthvi Gowda
Postdoctoral Research Fellow at DFCI, Harvard Medical School
Boston, MA
https://www.linkedin.com/in/bishwarup-sarkar
Bishwarup Sarkar
Research Assistant at Antimicrobial Discovery Centre, Northeastern University, Boston | Graduate Student (Biotechnology Program) at Northeastern University, Boston
Boston, MA
https://in.linkedin.com/in/tooba-khan-990b701ba
Tooba Khan
Trainee at Sun Pharma Advanced Research Center.
Vadodara
https://in.linkedin.com/in/dhruvi-kakadiya-4b3bb2175
Dhruvi Kakadiya
Junior Research Fellow
Vadodara
https://in.linkedin.com/in/khushi-mandaliya-0495731b4
Khushi Mandaliya
Pursuing Biomedical Science with specialization in Neuroscience
Vadodara
https://www.linkedin.com/in/priyanka-sigar-621b11ab
Priyanka Sigar
PhD @UCLA working on Autism | Brain connectivity dynamics | fMRI.
Los Angeles, CA
https://in.linkedin.com/in/nirali-kargathara-67b065202
Nirali Kargathara
Techno-Commercial Executive-Gujarat at MagGenome Technologies pvt. Ltd.
Vadodara
https://in.linkedin.com/in/aditi-vichare-3843891b4
Aditi Vichare
Content creation Assistant at Igniters, E-Cell
Mumbai
https://in.linkedin.com/in/nisha-patel-2b15b9202
Nisha Patel
Student at GSFC University
Vadodara
https://ca.linkedin.com/in/kush-shah-11b776188
Kush Shah
Enthusiastic about imports and exports
Canada
https://www.linkedin.com/in/apoorvashankar
Apoorva Shankar
Research Associate at Rejuvenation Technologies Inc.
San Francisco Bay Area
https://www.linkedin.com/in/hampusengstroem
Hampus Engstroem
Field Application Scientist | 908 Devices
Norfolk, VA
Neeraja Parameswaran
      
          



            
              
        
              
  

    
        Aanal is a very motivated and dedicated researcher with strong technical, critical thinking, and organizational skills. I have collaborated with her many times and admire the high quality work she has presented for all her projects with clear documentation and reporting of data. She is a very friendly co-worker who can communicate effectively, and always has a cheerful and positive attitude. I have greatly enjoyed working with her and highly recommend her. She will be a great asset to any company.
Aanal Bhatt
https://in.linkedin.com/in/aanal-bhatt-723683a5
Ahmedabad
Aanal B.
https://www.linkedin.com/in/a-positive-bhatt
Optimist | Conscientious | Family Oriented | Crime Fiction Enthusiast |
Hartford, CT
Aanal Bhatt
https://www.linkedin.com/in/aanalbhatt
BD Leader for SMB & Startups at Amazon Web Services
Seattle, WA
Aanal Bhatt
https://in.linkedin.com/in/aanal-bhatt-778346a9
Deputy Manager at Vadilal Industries Limited
Ahmedabad