Thilanga Liyanage (Ph.D.)
Associate Analytical Scientist at Hovione
Organic Synthesis, Polymers, Drug Design, Drug Delivery, Formulation Development
Dynamic and results-oriented professional with expertise in synthetic organic chemistry, polymer chemistry, and analytical chemistry.

R&D Skills:
•Expertise in analytical testing of raw materials, drug product intermediates, and drug products in research, development, registration, and commercial stages. 
•Expertise in donor-acceptor (D-A) conjugated polymer preparation via Stille coupling, free radical polymerization, ring-opening polymerization, poly (beta-amino ester) (PBAE) based hydrogels and polymeric pro-drugs preparation.
•Polymeric prodrug, hydrogel synthesis,  drug-loaded Poly Lactic-co-Glycolic Acid (PLGA) microsphere preparation, and design formulation strategies/implants for in-vivo animal studies.
•Analyze pharmacokinetic data and design novel formulation strategies for dual drug delivery applications.
•Study in-vitro/ in-vivo osteogenesis potential of polymeric prodrugs.

Analytical Instruments:
UV-VIS, HPLC, MS, GC/ Headspace GC, AAS, NMR, FTIR, LC-MS, MALDI, fluorescence spectroscopy, GPC, TGA, DSC, WAXD, micro CT, Voltammetry, Karl Fischer Titrators.

Professional Software/packages: 
Microsoft Office, Chemdraw, Empower, Origin, Scifinder, Endnote, TA analysis, MestReNova.
Hovione
https://www.linkedin.com/company/hovione
Associate Analytical Scientist
•HPLC method development/ validation/transfer for Assay, Purity, and Related substances methods per ICH guidelines. Assigned Custom Fields to calculate the relevant parameters.
•GC/ Headspace GC method development/validation/ transfer for Residual Solvent Content and Purity methods per ICH guidelines. Assigned Custom Fields to calculate the relevant parameters (10 plus projects).
•Troubleshoot method feasibility issues and improve the method robustness (HPLC, GC). Due to this Quality Control division was able to perform their analysis smoothly with less number of deviations/ out of specifications (OOS).
•Provided laboratory investigations, analytical support/ data to finalize CAPAs and initiate Change Controls.
•GMP documents preparations such as Analytical Methods, Method Validation Protocols, and Reports.
East Windsor, New Jersey, United States
https://media-exp1.licdn.com/dms/image/C4E0BAQEN93Upl9FTMQ/company-logo_100_100/0/1605286003835?e=1655942400&v=beta&t=wWjvxjMpf8AzE45ngEY73oovw5OZYII35C2CgayOfAA
Sri Lanka Pharmaceutical Laboratory (SLPL)
Senior Research Investigator
•Formulation development using excipients and active pharmaceutical ingredients (API).
•Performed quality control studies using USP and BP analytical standards (Dissolution, Friability, Disintegration, HPLC, etc.).
•Developed HPLC methods for in-house standardizations.
•Reviewed and monitored stability data on new and reformulated products. 
•Helped on preparing SOPs and other relevant documents to obtain the ISO 17025 accreditation certificate.
Colombo, Sri Lanka
University of Kentucky College of Engineering
https://www.linkedin.com/company/ukyengineering
Postdoctoral Scholar Biomedical Engineering Department
•Designed and synthesized Simvastatin based polymeric pro-drugs for bone regeneration.
•Designed porous scaffolds for tissue engineering and dual drug delivery applications.
•Designed formulations/implants to perform in-vivo studies.
•Synthesized drug loaded PLGA microspheres (single and double emulsion).
•Synthesized drug loaded PBAE microspheres.
•Evaluated 3 D printing potential of polymeric prodrug scaffolds.
Lexington, Kentucky
https://media-exp1.licdn.com/dms/image/C4D0BAQGZze0-Xhmcdg/company-logo_100_100/0/1556042748029?e=1655942400&v=beta&t=kdwd5vBMztaO8t2sSSn3sAdbPfwrlCo4C-qEDFy3zPs
University of Kentucky Molecular and Cellular Biochemistry Department
Postdoctoral Scholar
•Designed and synthesized novel fluorinated Pittsburg compound B (PIB) analogs to chemically map the Aß amyloid plaques in Alzheimer’s brains.
Lexington, Kentucky
First Class Honors
Bachelor of Science (BSc), Chemistry
University of Colombo
https://www.linkedin.com/school/university-of-colombo/
https://media-exp1.licdn.com/dms/image/C510BAQHqtA7-ZAyi0Q/company-logo_100_100/0/1579845499018?e=1655942400&v=beta&t=GGHetSrxN58_ERGmMxLBND5q1kZknXEBdmXPoCFFIbA
Organic Chemistry
Doctor of Philosophy (Ph.D.)
University of Kentucky
https://www.linkedin.com/school/universityofkentucky/
https://media-exp1.licdn.com/dms/image/C4E0BAQHCQccfzoFmmg/company-logo_100_100/0/1587569301505?e=1655942400&v=beta&t=3z27JQplYYkJKKBezpni8ve5gup05LTO8s3nOgXAN5c
Member of the Biomedical Engineering Society (BMES)
-
Society for Biomaterials (SFB)
-
Member of the American Chemical Society (ACS)
-
Member of the Materials Research Society (MRS)
-
Member of the Sri Lanka Association for the Advancement of Science (SLAAS)
-
Biodegradable polymerized simvastatin stimulates bone formation
Acta Biomaterialia
https://www.sciencedirect.com/science/article/pii/S1742706119303022?dgcid=rss_sd_all
Biodegradable simvastatin-containing polymeric prodrugs with improved drug release
ACS Biomaterials science & Engineering
https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00884
Drug delivery systems and controlled release
Encyclopedia of Biomedical Engineering
https://www.sciencedirect.com/science/article/pii/B9780128012383110372?via%3Dihub
Vancomycin and Poly(simvastatin) containing scaffolds for dual drug delivery applications
ACS Applied Biomaterials
https://pubs.acs.org/doi/10.1021/acsabm.9b00207
Conjugated? Copolymers from a Pechmann Dye Derivative
Macromolecular Chemistry and Physics
https://onlinelibrary.wiley.com/doi/abs/10.1002/macp.201600175
Fluorinated arene, imide, and pyrrolidinone base donor-acceptor polymers
LAP Lambert Academic Publishing
https://www.amazon.com/Fluorinated-Arene-Pyrrolidinone-Acceptor-Polymers/dp/3659748153
Thieno[3,4-c]pyrrole-4,6-dione-based donor-acceptor conjugated polymers for Solar Cells
Macromolecules
https://pubs.acs.org/doi/abs/10.1021/ma101878w
Associate Editorial Board member Petroleum & Petrochemical Engineering Journal (PPEJ)
-
Reviewer
-
1. ACS Applied material and Interfaces
2. International Journal of Molecular Medicine
3. Royal Society Open Science
4. ACS Biomaterials Science & Engineering, 
5. Applied Surface Science, 
6. Experimental & Therapeutic Medicine, 
7. Journal of Biomedical Materials Research Part B (Applied Biomaterials)
Reviewer Certificate, Journal of Biomedical Materials Research, Part B, Applied Biomaterials
Society For Biomaterials
https://www.linkedin.com/in/deepthika-de-silva-68a07ba5
Deepthika De Silva
Student at Louisiana State University and Agricultural and Mechanical College
Baton Rouge, LA
https://www.linkedin.com/in/isaac-sitienei-235a8a74
Isaac Sitienei
Assistant Professor at Austin Peay State University
San Marcos, TX
https://www.linkedin.com/in/jonathan-musila-48085420
Jonathan Musila
Using Advanced Biochemistry and Enzymology to Solve Biological Problems!
Malvern, PA
https://www.linkedin.com/in/wmtorres
William Torres, PhD
Biotechnology Consultant
Philadelphia, PA
https://www.linkedin.com/in/kristimporter
Kristi M. Porter, Ph.D.
Managing Director, NIH Oxford-Cambridge Scholars Program at the National Institutes of Health
Washington DC-Baltimore Area
https://www.linkedin.com/in/dilrukshi-hewage-79288930
Dilrukshi Hewage
Senior Statistician at BD
Franklin Lakes, NJ
https://www.linkedin.com/in/pamlea-brady-phd-90024150
Pamlea Brady, PhD
Department Chair at Talladega College
Birmingham, AL
https://in.linkedin.com/in/shamimul-ahsan-5b29a8128
shamimul Ahsan
--
Bengaluru
https://www.linkedin.com/in/mani-pokharel-2808a475
Mani Pokharel
Faculty at Mercer University
Macon, GA
https://np.linkedin.com/in/prakash-khanal-0b443a43
prakash khanal
Adjucnt lecturer at PAHS SOM
Nepal
https://www.linkedin.com/in/sereke-zerayesus-b025b232
Sereke Zerayesus
Researcher at UIC College of Medicine
Greater Chicago Area
https://np.linkedin.com/in/man-karki-b7817ab6
Man karki
Student at Tribhuvan Vishwavidalaya
Nepal
https://np.linkedin.com/in/deepak-pudasainee-1a79bb55
Deepak Pudasainee
Mathematics Lecture at Trinity College,Dillibazar, Kathmandu And REHDON College, Samakhusi, Kathmandu, Nepal
Nepal
https://www.linkedin.com/in/kippvs
Kipp van Schooten
Principal Electrical Engineer at Northrop Grumman
Salt Lake City, UT
https://www.linkedin.com/in/sajjan-koirala-15996639
Sajjan Koirala
St. Jude Children's Research Hospital
Memphis, TN
https://np.linkedin.com/in/deergh-shahi-637b5917b
Deergh Shahi
Assistant Professor at Patan multiple Campus, Patandhoka, Lalitpur
Nepal
https://www.linkedin.com/in/redavi
Rachel Davis
Graduate Research Assistant at University of Notre Dame
South Bend, IN
https://www.linkedin.com/in/kyle-brook-5b7743125
Kyle Brook
Student at University of Illinois at Chicago
Greater Chicago Area
https://www.linkedin.com/in/daniel-sun-86635b37
Daniel Sun
Senior Scientist at Pelage Pharmaceuticals | Medicinal Chemist | Project Leadership | Methods Development
Los Angeles, CA
The last confirmation for the alumni day is engineer Pedro Andara. Finished the course at IST in 2011 after an internship in Belgium at GOVI. In 2013…
https://www.linkedin.com/signup/cold-join
Liked by Thilanga Liyanage (Ph.D.)
Happy to share my first-ever post on LinkedIn. Our most recent paper, "Water-Soluble Palladium Nanoclusters as Catalysts in Ligand-Free…
https://www.linkedin.com/signup/cold-join
Liked by Thilanga Liyanage (Ph.D.)
Dear women, I am empowering and supporting you to continue to fight for yourselves and for your rights, to be more educated, independent, and…
https://www.linkedin.com/signup/cold-join
Liked by Thilanga Liyanage (Ph.D.)