Arif Rahman, Ph.D.
Clinical Research Scientist I at Impact Pharmaceutical Services
Clinical Research Scientist || Medical Writer || Pharmacologist & Toxicologist
Impact Pharmaceutical Services
https://www.linkedin.com/company/impact-pharmaceutical-services
Clinical Research Scientist I
Duties/responsibilities:
* Author clinical, scientific, and regulatory submission documents such as study protocols, clinical study reports, subject narratives, clinical investigator brochures, and other documents as assigned.
* Perform quality control review of regulatory submission documents.
Raleigh-Durham-Chapel Hill Area
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Impact Pharmaceutical Services
https://www.linkedin.com/company/impact-pharmaceutical-services
Medical Writing Fellow
Duties/responsibilities:
* Author clinical, scientific, and regulatory submission documents such as clinical study reports, subject narratives, and other documents as assigned.
* Perform quality control review of regulatory submission documents.
Raleigh-Durham-Chapel Hill Area
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PLOS One
Reviewer
Nature Research (Publishing)
https://www.linkedin.com/company/natureportfolio.
Reviewer
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Environmental Factor
Science Writer
▪ Wrote and edited non-technical stories on the latest scientific discoveries across the NIEHS
▪ Wrote and edited feature stories on special events such as conferences and distinguished lecture series.
▪ Interviewed scientists to highlight the ‘big picture’ aspect of their research for general public.

Sample writing pieces-
▪ https://factor.niehs.nih.gov/2021/1/science-highlights/trainor/index.htm
▪ https://factor.niehs.nih.gov/2020/12/science-highlights/aging-cancer-interplay/index.htm
▪ https://factor.niehs.nih.gov/2020/10/science-highlights/xchromosome-inactivation/index.htm
▪ https://factor.niehs.nih.gov/2020/7/community-impact/reduce-exposure/index.htm
▪ https://factor.niehs.nih.gov/2020/8/papers/dir/index.htm#a1
▪ https://factor.niehs.nih.gov/2020/6/papers/dir/index.htm#a4
▪ https://factor.niehs.nih.gov/2020/5/papers/dir/index.htm#a4
National Institute of Environmental Health Sciences (NIEHS)
https://www.linkedin.com/company/national-institute-of-environmental-health-sciences-niehs-
Postdoctoral Fellow
Used gene coexpression-based network analysis to investigate chemical-induced cardiovascular toxicity.
Data type and tools:
- High-throughput gene expression (e.g. microarray) data
- R & R Shiny
- Partek Genomics Suite
- MySQL/PostgresSQL
- Tableau
- Cytoscape
- JMP
- Ingenuity Pathway Analysis (IPA)



Supervisors: Dr. Scott Auerbach and Dr. Brian Berridge.
Raleigh-Durham, North Carolina Area
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The University of Tennessee Health Science Center
https://www.linkedin.com/company/university-of-tennessee-health-science-center
Graduate Research Assistant
Research Experience:
* Designed in vitro and ex vivo toxicological/mechanistic study involving CYP enzymes
* Conducted pharmacodynamic and toxicological analysis of novel CYP2E1 inhibitors (lead optimization)
* Studied drug- drug/disease interaction (DDI) involving alcohol-HIV-anti-retroviral drugs
* Conducted in vitro pharmacokinetic analysis of anti-retroviral drugs using LC-MS/MS
* Executed enzyme activity assay using liver microsomes/baculosomes
* Performed screening of enzyme substrate/inhibitor, kinetics study (e.g. Km, Vmax, IC50 determination)
* Studied exosomes biology; isolation, characterization, and downstream effects on cell systems 
* Used exosomes as potential biological carrier for large molecules such CYP enzymes 
* Extensive experience in working in biosafety level (BSL)- 2 & 3 facility
* Gained theoretical knowledge and understanding of Pop PK, PBPK modeling, WinNonlin, NONMEM
* Participated in hands on training and exercises on PKPD of protein therapeutics (Dr. Bernd Meibohm)

Technical skills:
•	Enzyme activity/inhibition assay
•	Metabolic assay using human liver microsomes
•	Molecular docking
•	Flow cytometry
•	Cell viability/cytotoxicity assay
•	ELISA
•	LCMS/MS method development and validation
•	Western blot
•	qRT-PCR
•	DNA/RNA/protein extraction/quantification
•	DNA damage assay
•	Cytokine assay
•	Immunohistochemical assay using fluorescence microscopy
•	Antioxidant activity assay
•	Glutathione assay
•	Lipid peroxidation assay
•	Exosomes isolation/characterization assay
•	Membrane protein extraction assay
•	Nanoparticle uptake assay 

Software skills:
R, GraphPad Prism, SAS, Microsoft Excel

Cell culture experience:
•	Hepatocytes (primary & immortalized)
•	Monocytes & Macrophages 
•	Monocyte-derived microglia
•	HIV infected monocytes (U1 cells)
•	Astrocytes (human & mouse)
•	Neuroblastoma cell
•	Endothelial cells (in vitro BBB model)
•	Human plasma (healthy & patient sample)

https://scholar.google.com/citations?user=l3DM3ysAAAAJ&hl=en
Greater Memphis Area
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The University of Tennessee Health Science Center
https://www.linkedin.com/company/university-of-tennessee-health-science-center
Graduate Teaching Assistant
As a Teaching Assistant of Pharmacokinetics and Dose Optimization, I helped P2 students with their recitations and grading the exams, quizzes, and assignments.
My responsibility in the compounding lab was to teach the Pharm D students aseptic techniques of administering parenteral compounds.
As a Teaching Assistant of Pharmaceutics, I took care of the grading & uploading the grades in the blackboard as well as updating the students regarding their progress in the course during the semester.
Greater Memphis Area
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FDA
https://www.linkedin.com/company/fda
ORISE Fellow
* Learnt predictive model development for drug-induced liver injury (DILI)
* Used R, KNN, 5-fold cross validation along with other data mining approaches to build the models
* Learnt data preprocessing, feature scaling, regression modeling, etc. using R
* Gained knowledge on DILIrank, the largest reference DILI drug list developed by FDA
* Studied liver toxicity knowledge base and DILI classification for assessment of human liver injury
Pine Bluff, Arkansas Area
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Incepta Pharmaceuticals Ltd.
https://www.linkedin.com/company/incepta-pharmaceuticals-ltd-
Senior Product Manager
Roles and achievement:
•	Supervised two new team members in their transition into the workplace and helped them planning the marketing strategies for their assigned products.
•	Managed marketing and distribution of 2 major revenue earning products of the company successfully.
•	Prepared annual reports for my team using Microsoft Excel and PowerPoint.
Tejgaon, Dhaka
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Incepta Pharmaceuticals Ltd.
https://www.linkedin.com/company/incepta-pharmaceuticals-ltd-
Product Manager
Roles and achievement:
•	Implemented novel marketing strategies for amino acid preparation and made it the 2nd largest brand nationally (from 6th position) in terms of annual sales value.
•	Re-launched the iron preparation with change in packaging which added around 7.5 million BDT extra to the company’s total monthly revenue.
•	Introduced two new generic medicines into market which added around 5 million BDT to the company’s monthly revenue.
•	Anchored the company’s biggest year-end celebration ‘Annual Conference (2012)’.
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Essentials Drug Company Limited, Bangladesh
Intern
I had an unique opportunity to work as an intern in the  country's  only state owned Pharmaceutical Company, Essential Drugs Company Limited. It's main objective is to manufacture quality drugs at an affordable price & supply to the Government Hospital and other Health Institutions. The company is the major  supplier of  Essential Drugs to the Government Hospitals, Civil Surgeon’s Offices, Health Institutions of Government, Non-Government and International (Non-profit makings) Organizations like UNICEF, WHO etc.

During my internship, I had hands on training on multiple aspects of drug manufacturing such as  R&D, QA/QC, regulatory approval, and marketing and distribution. The experience that I gathered here helped me tremendously to find the proper direction in my career in pharmaceutical industry.
Dhaka, Bangladesh
Pharmacology and Toxicology
Doctor of Philosophy - PhD
The University of Tennessee Health Science Center
https://www.linkedin.com/school/university-of-tennessee-health-science-center/
Dissertation: "Identification of novel CYP2E1 inhibitor to investigate cellular and exosomal
CYP2E1-mediated toxicity"
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Clinical Pharmacy and Pharmacology
Master of Science - MS
University of Dhaka
https://www.linkedin.com/school/dhakauniversity/
Thesis: "Pharmacokinetic effect of drug-drug interaction between Clopidogrel and Omeprazole in healthy human volunteer"
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Pharmacy
Bachelor of Pharmacy (B.Pharm.)
University of Dhaka
https://www.linkedin.com/school/dhakauniversity/
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American Chemical Society (ACS)
Graduate Student Membership
Student Academic Alliance chapter at LifeScienceTennessee
Member
Society on Neuroimmune Pharmacology (SNIP)
Graduate student member
American Association of Pharmaceutical Scientists (AAPS)
Student Member
Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages
Nature Scientific Reports
https://www.nature.com/articles/s41598-020-60684-1
Cytochrome P450 Enzymes for the Synthesis of Novel and Known Drugs and Drug Metabolites
Pharmaceutical Biocatalysis by Jenny Stanford Publishing
https://doi.org/10.1201/9780429295034
https://www.crcpress.com/Pharmaceutical-Biocatalysis-Fundamentals-Enzyme-Inhibitors-and-Enzymes/Grunwald/p/book/9789814800617
Plasma exosomes exacerbate alcohol- and acetaminophen-induced toxicity via CYP2E1 pathway
Nature Scientific Reports
https://doi.org/10.1038/s41598-019-43064-2
Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies
Journal of Neuroimmune Pharmacology
https://link.springer.com/article/10.1007%2Fs11481-019-09848-z
In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication
Toxicology Letters
https://doi.org/10.1016/j.toxlet.2018.04.023
Novel elvitegravir nanoformulation approach to suppress the viral load in HIV-infected macrophages
Biochemistry and Biophysics Reports
http://www.sciencedirect.com/science/article/pii/S2405580817302145
Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors
Pharmacology Research & Perspectives
http://onlinelibrary.wiley.com/doi/10.1002/prp2.362/full
Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications
Biochemical and Biophysical Research Communications
http://www.sciencedirect.com/science/article/pii/S0006291X17315036
Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways
PLOS ONE
http://dx.doi.org/10.1371/journal.pone.0163827
Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method
PLOS ONE
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149225
Advanced SAS
-
Bio-statistics for health science I
-
Bio-statistics for health science II
-
Drug Metabolism
-
Drug stability and chemical kinetics
-
Entrepreneurship in Pharmaceutical and Biomedical Sciences
-
Essentials of Animal Experimentation
-
Fundamentals of SAS for epidemiology
-
Integrity in the conduct of Scientific Research
-
Introduction to R Part I
-
Introduction to R Part II
-
Pharmaceutical Analysis
-
Pharmaceutical Preformulation and Drug Product Development
-
Pharmacokinetics and Dose optimization
-
Pharmacokinetics, Pharmacodynamics and Drug Development (Advanced Pharmacokinetics)
-
Population Pharmacokinetics
-
Education
AAPS student chapter
Chair
* Represented the Student Chapter for UTHSC at AAPS meetings
* Directed the Student Chapter and presided at its different meetings
* Appointed committee members and committee Chairs as necessary.
Education
AAPS Student Chapter
Chair-elect
Assisted the Chair or sometimes acted as Chair in the absence of the Chair or as necessary in organizing journal club seminars and other workshops associated with American Association of Pharmaceutical Scientists student chapter.
Education
Graduate Student Executive Committee (GSEC) at UTHSC
Secretary
To be a part of the GSEC allowed me to be involved in the services of my fellow colleagues at UTHSC in several aspects such as helping in creating platforms for students to show their work in the broader scientific community, resolving issues which are currently hampering smooth progress in the school etc.
Social Services
International Students Association at UTHSC
President
Helped new international students to smoothly start their journey at UTHSC by helping to overcome the culture shock and provide with advice that may guide them to a better graduate life.
Social Services
International Students Association at UTHSC
Secretary
Health
IPECS Advisory Committee (UTHSC Inter-professional Student Council)
Committee member
The IPECS advisory committee acts as a liaison between the student body and the Office of Inter-professional Education and Clinical Simulation. Activities included-

- Served as student representatives on IPECS committees
- Provided student feedback on college curriculums and suggested ways to integrate IPE
- Informed IPECS about IPSC activities
Toastmasters International
https://www.linkedin.com/company/toastmasters-international
Member
To improve my communication and leadership skill I joined Toastmasters international. In the process, I get to help other members to improve their communication and leadership skill.
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http://www.linkedin.com/learning/grammar-foundations
Grammar Foundations
www.linkedin.com
LinkedIn
http://www.linkedin.com/learning/digital-transformation-2
Digital Transformation
www.linkedin.com
LinkedIn
http://www.linkedin.com/learning/writing-in-plain-english
Writing in Plain English
www.linkedin.com
LinkedIn
https://coursera.org/share/76d9383485f7fd912c621c0195a2a3f3
Writing in the Sciences
coursera.org/verify/X6CE2K3Y849P
coursera.org
Stanford University
https://coursera.org/share/36c2ae4a2ca5f9df1769217596580562
Introduction to Statistics & Data Analysis in Public Health
coursera.org
Imperial College London
https://courses.edx.org/certificates/239429748a074df2899c34c58816dfec
Improving Global Health: Focusing on Quality and Safety
courses.edx.org
Harvard Global Health Institute
https://www.coursera.org/account/accomplishments/certificate/MYCGQSPQRFVP
Network Analysis in Systems Biology
www.coursera.org
Coursera
Certification of Attendance by ORAQ Regulatory Affairs Training Program at Duke University
Duke University School of Medicine
https://www.datacamp.com/statement-of-accomplishment/course/a6e2a84554f4771474e65ddcb5d5f599ce593358
Data Manipulation with dplyr in R
#10672661
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/8e1f0e1668d0ff1d056ae6659d99684c793bbbfe
Importing Data in R (Part 1)
#9547166
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/5d2cc13a9b17115ff1b413da55b41fa45460d3de
Cluster Analysis
#9918917
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/c6e7247a25c88a4fed0f4ae7ceff9bd9f01f51a3
Modeling with Data in the Tidyverse
#9727767
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/18a5053c429556254e3dbf53ae9482c8838680c9
Data Visualization with ggplot2 (Part 2)
9293922
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/b20d4742310619745b3a89bf8925e9a616fb9b61
Exploratory Data Analysis in R: Case Study
#9546382
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/7da676ed854e41ec32114bbfa3a0a0f8f2408fff
Data Visualization with ggplot2 (Part 1)
6506713
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/8ab28248921511d31b2387df0c2e2b4c81fda063
Introduction to the Tidyverse
1
www.datacamp.com
DataCamp
http://ude.my/UC-KJC7CRAO
Introduction to Finance, Accounting, Modeling and Valuation
UC-KJC7CRAO
ude.my
Udemy
http://ude.my/UC-0SCKR91V
Machine Learning A-Z:  Hands-on Python and R
UC-0SCKR91V
ude.my
Udemy
http://www.linkedin.com/learning/data-wrangling-in-r
Data Wrangling in R
AfQB1JIvOvzSQ516zTg-mC4Jfw6p
www.linkedin.com
LinkedIn
https://www.coursera.org/account/accomplishments/verify/3DHCK9YALAK7
Drug Development
3DHCK9YALAK7
www.coursera.org
University of California San Diego on Coursera
https://www.datacamp.com/statement-of-accomplishment/course/8c5e0cb16ba203533f58c6730b89fe76103a39b5
Intermediate R Course
6,395,700
www.datacamp.com
DataCamp
https://www.datacamp.com/statement-of-accomplishment/course/1f71db4ca4b1fa0fa9a8ad854848561999d65ecc
Introduction to R Course
2,090,571
www.datacamp.com
DataCamp
https://www.coursera.org/account/accomplishments/verify/YFTPUH723TZY
R Programming
YFTPUH723TZY
www.coursera.org
Johns Hopkins Bloomberg School of Public Health
https://www.coursera.org/account/accomplishments/certificate/5YQUR52LB9RT
The Data Scientist’s Toolbox
5YQUR52LB9RT
www.coursera.org
Johns Hopkins Bloomberg School of Public Health
The Comprehensive Industrial Course in the Preparation of Parenteral Products
Plough Center for Sterile Drug Delivery Systems
https://app.box.com/s/81tujdzeziyg4plug7erjy5vn61lkl34
Certificate on Pharmacokinetics and pharmacodynamics of protein therapeutics: Concept and Hands on exercises
app.box.com
College of Pharmacy, University of Tennessee Health Science Center
https://www.linkedin.com/in/kasturipuranam
Kasturi Puranam, Ph.D.
Clinical Research Scientist/Medical Writer
Durham, NC
https://www.linkedin.com/in/alicia-carreiro-454a5768
Alicia Carreiro
Clinical Research Scientist I at Impact Pharmaceutical Services
Raleigh, NC
https://www.linkedin.com/in/dominic-luciano-58658578
Dominic Luciano
Clinical Research Scientist at Impact Pharmaceutical Services
Durham, NC
https://www.linkedin.com/in/ryanovercash1983
Ryan Overcash
Owner and independent consultant at Clinsolutions, LLC
Raleigh, NC
https://in.linkedin.com/in/rutuja-lad-383627138
Rutuja Lad
Jr. Research Associate Scientist at Macleods Pharma, R&D Mumbai
Mumbai
https://www.linkedin.com/in/l-alexis-hoeferlin-684a8525
L. Alexis Hoeferlin
Clinical Research Scientist II at Impact Pharmaceutical Services
Richmond, VA
https://www.linkedin.com/in/amritha-kidiyoor-ms-phd-96881a13
AMRITHA KIDIYOOR, MS, PhD
Senior Clinical Research Scientist at Impact Pharmaceutical Services
Raleigh-Durham-Chapel Hill Area
https://www.linkedin.com/in/stephanie-mixson-byrd-ph-d-rac-022bb925
Stephanie Mixson Byrd, Ph.D., RAC
Senior Clinical Research Scientist at Impact Pharmaceutical Services
United States
https://ca.linkedin.com/in/zahid-sadek-chowdhury
Zahid Sadek Chowdhury, Ph.D.
Cybersecurity Specialist Trainee | Research Scientist | Pharmaceutical industry | Let's connect!
Vancouver, BC
https://www.linkedin.com/in/caroline-drucker-98ab568
Caroline Drucker
Medical Writer
Durham, NC
https://www.linkedin.com/in/l-e-beth-wiener-drph-33079a93
L.E. Beth Wiener, DrPH
Research Statistician at RTI International
Durham, NC
https://www.linkedin.com/in/palak-patel-843969216
Palak Patel
--
Merrimack, NH
https://www.linkedin.com/in/bernicehuang
Bernice Wolen
Senior Medical Writer at Cardinal Health Regulatory Sciences
Germantown, TN
https://www.linkedin.com/in/danielle-garver-68a578138
Danielle Garver
Student Intern at Impact Pharmaceutical Services
Chapel Hill, NC
https://www.linkedin.com/in/christopher-del-corral-pharmd-18850877
Christopher del Corral, PharmD
Director, Clinical Development and Sciences at Legend Biotech
Westwood, NJ
https://in.linkedin.com/in/krisha-shah-633837121
Krisha Shah
Cancer Research Scientist
Mumbai
https://ca.linkedin.com/in/varunkatoch26
Varun K.
Masters In Regulatory Affairs at Northeastern University | Medical Devices | ICT Mumbai, 21 | Pharmaceutical Engineer
Toronto, ON
https://www.linkedin.com/in/kristen-moore-ph-d-24b75632
Kristen Moore, Ph.D.
Epidemiology | Infectious Disease | Women's Health
Durham, NC
https://www.linkedin.com/in/aschneibel
Andrea Schneibel
Science Writer at Oak Ridge National Laboratory,
Fusion and Fission Energy and Science & US ITER
Knoxville, TN
Narasimha Midde
      
          



            
              
        
              
  

    
        I have worked closely with Arif for more than two years. He is an excellent team player and a pleasant person to be around. The most striking thing about Arif is his ability to interact with people from diverse backgrounds and create an amicable atmosphere to move forward with any projects that he is involved in. I believe that Arif will be a great addition to any team either in the industry or academia. Ehsan Aziz
      
          



            
              
        
              
  

    
        Mr Arif Rahman is a very intelligent individual who takes keen interest in his work. 
His presence of mind and strong commitment to doing the right thing is much appreciated by his colleagues. 
His ability to go through issues at hand and develop clear concepts showed him to be an excellent candidate for future leadership. 
A significant portion of his work during his tenure at Incepta involved studying pharmacological aspect of different molecules so that he can identify and build on strategic advantages of each and promote these focal points. 
I believe he will be an asset to anyone who would like to involve him in their endeavor. 
Arif Rahman, Ph. D.
https://www.linkedin.com/in/arif-rahman1538
Founder@ HIL>>Postdoctoral Fellow⇨Space Health⇨Energy Enthusiastic>>Micro/Nanorobotics» RF & Biotechnology developer ⇨Archer & Marathon runner
Honolulu, HI